Medicine and Health Sciences Commons^™

Relationship Between Cognitive Performance, Physical Activity, And Socio-Demographic/Individual Characteristics Among Aging Americans, Imtiaz Masfique Dowllah, Juan Carlos Lopez-Alvarenga, Gladys Maestre, Ulku S. Karabulut, Michael Lehker, Murat Karabulut

School of Medicine Publications

Background: Physical activity (PA) has emerged as a promising approach to delay Alzheimer’s disease and related dementias, but the optimal intensity of PA to improve cognitive health remains unknown.

Objective: To evaluate the association between duration and intensity of PA and cognitive domains (executive function, processing speed, and memory) in aging Americans.

Methods: Linear regressions in hierarchical blocks for variable adjustment and the size of effect (η2) were analyzed by using the data of 2,377 adults (age = 69.3±6.7 years) from the NHANES 2011–2014.

Results: Participants with 3–6 h/week of vigorous- and > 1 h/week of moderate-intensity PA scored significantly higher …

The Type 2 Diabetes Knowledge Portal: An Open Access Genetic Resource Dedicated To Type 2 Diabetes And Related Traits, Maria C. Costanzo, Marcin Von Grotthuss, Jeffrey Massung, Dongkeun Jang, Dongkeun Jang, Lizz Caulkins, Ryan Koesterer, Clint Gilbert, Ryan P. Welch, John Blangero

School of Medicine Publications

Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories of these data seek to be disease-agnostic and therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is a public resource of genetic datasets and genomic annotations dedicated to type 2 diabetes (T2D) and related traits. Here, we seek to make the T2DKP more accessible to prospective users and more useful to existing users. First, we evaluate the T2DKP's comprehensiveness by comparing its datasets with those of other repositories. Second, we describe how researchers unfamiliar with human genetic data can begin …

Anti-Cancer Effect Of Cissus Quadrangularis On Human Glioblastoma Cells, Benxu Cheng, Yunlin Wei, Lili Guerra, Rozena Shirvani-Arani, Santiago Balderas, Laura Valdez, Andrew Tsin, Xiaoqian Fang

School of Medicine Publications

Objectives

Glioblastoma multiforme (GBM) is a common and fatal brain tumour in the central nervous system with a poor survival rate and a median survival time of 15 months only. The standard treatment is aggressive surgical resection followed by radiotherapy and chemotherapy. However, effective drugs available in chemotherapy are limited. This study was designed to evaluate, for the first time, the potential therapeutic effect of Cissus quadrangularis (CQ) in human glioblastoma cells and to investigate its possible mechanisms of action. Methods

In this study, we examined the anticancer activity of CQ in human glioblastoma U87 MG cells by cell viability …

Antagonism Between Prdm16 And Smad4 Specifies The Trajectory And Progression Of Pancreatic Cancer, Eric Hurwitz, Parash Parajuli, Seval Ozkan, Celine Prunier, Thien Ly Nguyen, Deanna Campbell, Creighton Friend, Allan Austin Bryan, Ting-Xuan Lu, Mohammed S. Razzaque

School of Medicine Publications

The transcription factor Prdm16 functions as a potent suppressor of transforming growth factor-beta (TGF-β) signaling, whose inactivation is deemed essential to the progression of pancreatic ductal adenocarcinoma (PDAC). Using the KrasG12D-based mouse model of human PDAC, we surprisingly found that ablating Prdm16 did not block but instead accelerated PDAC formation and progression, suggesting that Prdm16 might function as a tumor suppressor in this malignancy. Subsequent genetic experiments showed that ablating Prdm16 along with Smad4 resulted in a shift from a well-differentiated and confined neoplasm to a highly aggressive and metastatic disease, which was associated with a striking deviation in the …

Hr Gene Variants Identified In Mexican Patients With Alopecia Areata, Andrés Ortiz-Ramírez, María Cristina Hernández-Jiménez, Iliana Berenice Guardiola-Avila, Erick De Jesús De Luna-Santillana, Amanda Alejandra Oliva-Hernández, María Lourdes Altamirano-García, Karina Janett Juárez-Rendón

School of Medicine Publications

Alopecia Areata (AA) is a multifactorial, dermatological disease characterized by non-scarring hair loss. Alterations in candidate genes, such as HR (Hairless), could represent a risk factor for its development. The aim of this study was to search for and analyze variants in exons 3, 15 and 17 of the HR gene in Mexican patients with AA. A total of 30 samples from both AA patients and healthy donors were analyzed in this study. Exons were amplified and sequenced using the Sanger method. Descriptive statistics and χ2 tests were used in the analysis of clinical–demographic characteristics and the comparison of allelic/genotypical …

Co-Alteration Network Architecture Of Major Depressive Disorder: A Multi-Modal Neuroimaging Assessment Of Large-Scale Disease Effects, Jodie P. Gray, Jordi Manuello, Aaron F. Alexander-Bloch, Cassandra Leonardo, Crystal Franklin, Sueng Choi, Franco Cauda, Tommaso Costa, John Blangero, David C. Glahn, Peter T. Fox

School of Medicine Publications

Major depressive disorder (MDD) exhibits diverse symptomology and neuroimaging studies report widespread disruption of key brain areas. Numerous theories underpinning the network degeneration hypothesis (NDH) posit that neuropsychiatric diseases selectively target brain areas via meaningful network mechanisms rather than as indistinct disease effects. The present study tests the hypothesis that MDD is a network-based disorder, both structurally and functionally. Coordinate-based meta-analysis and Activation Likelihood Estimation (CBMA-ALE) were used to assess the convergence of findings from 92 previously published studies in depression. An extension of CBMA-ALE was then used to generate a node-and-edge network model representing the co-alteration of brain areas …

Diurnal Variability Of Cortisol In The Pennsylvania Adult Smoking Study: Exploration Of Association With Nicotine Intake, Michael Machiorlatti, Nicole Krebs, Dongxiao Sun, Joshua E. Muscat

School of Medicine Publications

Cortisol in saliva, urine and plasma follows a diurnal rhythm typically characterized as a morning peak and a decline throughout the waking day. While often measured under controlled conditions, inter-individual differences in cortisol diurnal rhythms in free living populations are not well characterized. Cortisol levels may vary substantially between individuals and the level of variation may differ depending on the time of day. Further, associations with individual characteristics such as nicotine dependence on cortisol rhythms have not been adequately determined. We developed a Liquid Chromatography-Tandem Mass Spectrometry method to measure cortisol in saliva of 180 smokers from the Pennsylvania Adult …

Therapeutic Implications Of Uvb Irradiation In Cancer By Enhancing Anti-Tumor Immunity, Bilal B. Hafeez, Ed W. Alvarado, Dae Joon Kim

School of Medicine Publications

UVB irradiation is well known for its impact in the development of skin cancer. However, low UVB irradiation plays protective role against various human diseases including cancer through its effect on tumor suppression. This article summarizes the key findings of the paper by Park et al., which describes a novel molecular mechanism of moderate UVB irradiation in suppressing the growth of melanoma and colorectal cancer. Key observations in this paper are that moderate UVB irradiation can enhance tumor immunity by 1) increased infiltration of CD4+ and CD8+ T cells, 2) increased infiltration of CD103+ conventional type 1 dendritic cells (cDC1), …

Challenges In Closing The Gap Between Evidence And Practice: International Survey Of Institutional Surgical Stabilization Of Rib Fractures Guidelines, Jeff Choi, Avanti Badrinathan, Ryan Shine, Cecilia Benz, Alyssa Toia, Sarahann Whitbeck, Mark Kryskow, Thomas White, Jordan Kirsch

School of Medicine Publications

Background: Surgical stabilization of rib fractures (SSRF) has gained increasing interest over the past decade, yet few candidates who could benefit from SSRF undergo operative management. We conducted an international survey of institutional SSRF guidelines comparing congruence between practice and contemporary evidence. We hypothesized that few guidelines reflect comprehensive evidence to facilitate standardized patient selection, operation, and post-operative management.

Methods: A request for institutional rib fracture guidelines was distributed from the Chest Wall Injury Society. SSRF-specific guideline contents were extracted using a priori-designed extraction sheets and compared against 28 SSRF evidence-based recommendations outlined by a panel of 14 international experts. …

Role Of T Cells In Cancer Immunotherapy: Opportunities And Challenges, Hossain Ahmed, Aar Rafi Mahmud, Mohd. Faijanur - Rob – Siddiquee, Asif Shahriar, Partha Biswas, Md. Ebrahim Khalil Shimul, Shahlaa Zernaz Ahmed, Tanzila Ismail Ema, Nova Rahman, Md. Arif Khan

School of Medicine Publications

Immunotherapies boosting the immune system's ability to target cancer cells are promising for the treatment of various tumor types, yet clinical responses differ among patients and cancers. Recently, there has been increasing interest in novel cancer immunotherapy practices aimed at triggering T cell-mediated anti-tumor responses. Antigen-directed cytotoxicity mediated by T lymphocytes has become a central focal point in the battle against cancer utilizing the immune system. The molecular and cellular mechanisms involved in the actions of T lymphocytes have directed new therapeutic approaches in cancer immunotherapy, including checkpoint blockade, adoptive and chimeric antigen receptor (CAR) T cell therapy, and cancer …

Klrf1, A Novel Marker Of Cd56bright Nk Cells, Predicts Improved Survival For Patients With Locally Advanced Bladder Cancer, Neelam Mukherjee, Niannian Ji, Xi Tan, Chun-Liang Chen, Onika D. V. Noel, Maria Rodriguez-Padron, Chun-Lin Lin, David G. Alonzo, Tim H. Huang, Robert S. Svatek

School of Medicine Publications

Background

Bladder tumor-infiltrating CD56bright NK cells are more tumor cytotoxic than their CD56dim counterparts. Identification of NK cell subsets is labor-intensive and has limited utility in the clinical setting. Here, we sought to identify a surrogate marker of bladder CD56bright NK cells and to test its prognostic significance.

Methods

CD56bright and CD56dim NK cells were characterized with the multiparametric flow (n = 20) and mass cytometry (n = 21) in human bladder tumors. Transcriptome data from bladder tumors (n = 351) profiled by The Cancer Genome Atlas (TCGA) were analyzed. The expression levels of individual markers in intratumoral …

International Consensus Statement On Allergy And Rhinology: Allergic Rhinitis – 2023, Sarah K. Wise, Cecelia C. Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Helene J. Krouse

School of Medicine Publications

Background

In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document.

Methods

ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus …

Commentary On Metabolic Health Disparities Affecting The Rio Grande Valley Mexican American Population: Seeking Answers Using Animal Models, Juan Carlos Lopez-Alvarenga, Cordelia Rasa, Jameela Banu, Shizue Mito, Alberto O. Chavez, Sara M. Reyna

School of Medicine Publications

Mexican Americans living in the Rio Grande Valley (RGV) have a high prevalence of type 2 diabetes (T2D). The US–Mexico border frontier has a unique blended culture of American lifestyle and Mexican traditions. Some examples of the cultural traditions are the food and the use of herbal medicine, but these traditions are in danger of disappearing after a very short number of generations living in the United States. This article describes the use of animal models under experimental conditions to solve practical questions (etiology or treatment). We performed studies with murine (ie, mouse and rat) models to elucidate the characteristics …

Aspiration Thrombectomy Of M2 Middle Cerebral Artery Occlusion To Treat Acute Ischemic Stroke: A Core Lab–Adjudicated Subset Analysis From The Complete Registry And Literature Review, Johanna T. Fifi, Kurt Yaeger, Stavros Matsoukas, Ameer E. Hassan, Albert Yoo, Sunil A. Sheth, Osama O. Zaidat

School of Medicine Publications

Background

Although the benefits of aspiration thrombectomy for treating acute ischemic stroke caused by proximal large vessel occlusion have been established, fewer data are available for evaluating aspiration thrombectomy of distal occlusion. The objective of this study was to evaluate, by means of prospectively collected data, the safety and efficacy of aspiration thrombectomy in patients with M2 middle cerebral artery (MCA) occlusion.

Methods

This study is a subset analysis of a global prospective multicenter observational registry that included patients who presented with either anterior or posterior large vessel occlusion and were eligible for mechanical thrombectomy using the Penumbra System including …

Diminishing Benefits Of Urban Living For Children And Adolescents’ Growth And Development, Ncd Risk Factor Collaboration (Ncd-Risc), Anu Mishra, Bin Zhou, Andrea Rodriguez-Martinez, Shina Avi, Moran Blychfeld Magnazu, Ronit Endevelt, Jochanan Stessman, Gladys E. Maestre, Jesus D. Melgarejo

School of Medicine Publications

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1,2,3,4,5,6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. …

Xylazine In The Opioid Epidemic: A Systematic Review Of Case Reports And Clinical Implications, Shahana Ayub, Shanli Parnia, Karuna Poddar, Anil K. Bachu, Amanda Sullivan, Ali M. Khan, Saeed Ahmed, Lakshit Jain

School of Medicine Publications

Introduction and objectives: The opioid overdose epidemic is exacerbated by the emergence of Xylazine as an illicit drug adulterant. Xylazine, a veterinary sedative, can potentiate opioid effects while also causing toxic and potentially fatal side effects. This systematic review aims to assess the impact of Xylazine use and overdoses within the opioid epidemic context.

Method: A systematic search was conducted following PRISMA guidelines to identify relevant case reports, and case series related to Xylazine use. A comprehensive literature search included databases like Web of Science, PubMed, Embase, and Google Scholar, utilizing keywords and Medical Subject Headings (MeSH) terms related to …

Sars-Cov-2 Neutralizing Antibodies In Mexican Population: A Five Vaccine Comparison, Fernando Alcorta-Nuñez, Diana Cristina Perez-Ibave, Carlos H. Burciaga-Flores, Miguel Angel Garza, Moises Gonzalez-Escamilla, Patricia Rodriguez-Nino, Juan Francisco Gonzalez-Guerrero, Adelina Alcorta-Garza, Genaro A. Ramírez-Correa

School of Medicine Publications

Neutralizing antibodies (NAs) are key immunological markers and are part of the humoral response of the adaptive immune system. NA assays determine the presence of functional antibodies to prevent SARS-CoV-2 infection. We performed a real-world evidence study to detect NAs that confer protection against SARS-CoV-2 after the application of five vaccines (Pfizer/BioNTech, AstraZeneca, Sinovac, Moderna, and CanSino) in the Mexican population. Side effects of COVID-19 vaccines and clinical and demographic factors associated with low immunogenicity were also evaluated. A total of 242 SARS-CoV-2-vaccinated subjects were recruited. Pfizer/BioNTech and Moderna proved the highest percentage of inhibition in a mono-vaccine scheme. Muscular …

Prediction Of Coronary Artery Disease Using Urinary Proteomics, Dongmei Wei, Jesus D. Melgarejo, Lucas Van Aelst, Thomas Vanassche, Peter Verhamme, Stefan Janssens, Karlheinz Peter, Zhen-Yu Zhang

School of Medicine Publications

Aims: Coronary artery disease (CAD) is multifactorial, caused by complex pathophysiology, and contributes to a high burden of mortality worldwide. Urinary proteomic analyses may help to identify predictive biomarkers and provide insights into the pathogenesis of CAD.

Methods and results: Urinary proteome was analysed in 965 participants using capillary electrophoresis coupled with mass spectrometry. A proteomic classifier was developed in a discovery cohort with 36 individuals with CAD and 36 matched controls using the support vector machine. The classifier was tested in a validation cohort with 115 individuals who progressed to CAD and 778 controls and compared with two previously …

Editorial: Host-Microbiota And Cancer, Samantha Lopez, Manish Tripathi

School of Medicine Publications

No abstract provided.

Structural And Functional Asymmetry Of The Neonatal Cerebral Cortex, Logan Z. J. Williams, Sean P. Fitzgibbon, Jelena Bozek, Anderson M. Winkler, Ralica Dimitrova, Tanya Poppe, Andreas Schuh, Antonios Makropoulos, John Cupitt, Jonathan O’Muircheartaigh

School of Medicine Publications

Features of brain asymmetry have been implicated in a broad range of cognitive processes; however, their origins are still poorly understood. Here we investigated cortical asymmetries in 442 healthy term-born neonates using structural and functional magnetic resonance images from the Developing Human Connectome Project. Our results demonstrate that the neonatal cortex is markedly asymmetric in both structure and function. Cortical asymmetries observed in the term cohort were contextualized in two ways: by comparing them against cortical asymmetries observed in 103 preterm neonates scanned at term-equivalent age, and by comparing structural asymmetries against those observed in 1,110 healthy young adults from …

The Nairobi Declaration-Reducing The Burden Of Dementia In Low- And Middle-Income Countries (Lmics): Declaration Of The 2022 Symposium On Dementia And Brain Aging In Lmics, Gladys E. Maestre, Maria Carrillo, Raj N. Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Upal Roy, Noe Garza, Jennifer Cahn, Deepa Roy

School of Medicine Publications

Delegates of the 2022 Symposium on Dementia and Brain Aging in Low- and Middle-Income Countries, representing over 40 countries, met in Nairobi, Kenya, December 5–9 to highlight advances in dementia prevention, diagnosis, care, and research, as well as explore the future needs of the global community.

Cocktail-Party Listening And Cognitive Abilities Show Strong Pleiotropy, Samuel R. Mathias, Emma M. Knowles, Josephine Mollon, Peter T. Fox, Rene L. Olvera, Juan M. Peralta, Satish Kumar, Harald H. H. Goring, Ravi Duggirala, Joanne E. Curran, John Blangero, David C. Glahn

School of Medicine Publications

Introduction: The cocktail-party problem refers to the difficulty listeners face when trying to attend to relevant sounds that are mixed with irrelevant ones. Previous studies have shown that solving these problems relies on perceptual as well as cognitive processes. Previously, we showed that speech-reception thresholds (SRTs) on a cocktail-party listening task were influenced by genetic factors. Here, we estimated the degree to which these genetic factors overlapped with those influencing cognitive abilities.

Methods: We measured SRTs and hearing thresholds (HTs) in 493 listeners, who ranged in age from 18 to 91 years old. The same individuals completed a cognitive test …

Understanding The Burden Of Traumatic Injuries At The United States-Mexico Border: A Scoping Review Of The Literature, Benjamin A. Keller, Jeffrey Skubic, Monica Michelle Betancourt-Garcia, Romeo C. Ignacio, Jason S. Radowsky, Alan H. Tyroch, Carlos Palacio Lascano, Bellal Joseph, Collin Stewart, Aaron Silva

School of Medicine Publications

The United States-Mexico border is the busiest land crossing in the world and faces continuously increasing numbers of undocumented border crossers. Significant barriers to crossing are present in many regions of the border, including walls, bridges, rivers, canals, and the desert, each with unique features that can cause traumatic injury. The number of patients injured attempting to cross the border is also increasing, but significant knowledge gaps regarding these injuries and their impacts remain. The purpose of this scoping literature review is to describe the current state of trauma related to the US–Mexico border to draw attention to the problem, …

International Consensus Statement On Allergy And Rhinology: Allergic Rhinitis – 2023, Sarah K. Wise, Cecelia C. Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Helene J. Krouse

School of Medicine Publications

Background

In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document.

Methods

ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus …

Neuroarquitectura: Percepción De Cambios De La Atmósfera, Gladys E. Maestre, Yohany Albornoz

School of Medicine Publications

[Neuroarchitecture: perception of changes in the atmosphere]

Potential Mirna Biomarkers And Therapeutic Targets For Early Atherosclerotic Lesions, Genesio M. Karere, Jeremy P. Glenn, Ge Li, Ayati Konar, John L. Vandeberg, Laura A. Cox

School of Medicine Publications

Identification of potential therapeutic targets and biomarkers indicative of burden of early atherosclerosis that occur prior to advancement to life-threatening unstable plaques is the key to eradication of CAD prevalence and incidences. We challenged 16 baboons with a high cholesterol, high fat diet for 2 years and evaluated early-stage atherosclerotic lesions (fatty streaks, FS, and fibrous plaques, FP) in formalin-fixed common iliac arteries (CIA). We used small RNA sequencing to identify expressed miRNAs in CIA and in baseline blood samples of the same animals. We found 412 expressed miRNAs in CIA and 356 in blood samples. Eight miRNAs (miR-7975, -486-5p, …

Functional And Safety Outcomes Of Carotid Artery Stenting And Mechanical Thrombectomy For Large Vessel Occlusion Ischemic Stroke With Tandem Lesions, Mudassir Farooqui, Osama Zaidat, Ameer E. Hassan, Darko Quispe-Orozco, Nils Petersen, Afshin A. Divani, Marc Ribo, Michael Abraham, Johanna Fifi, Waldo R. Guerrero

School of Medicine Publications

Importance: Approximately 10% to 20% of large vessel occlusion (LVO) strokes involve tandem lesions (TLs), defined as concomitant intracranial LVO and stenosis or occlusion of the cervical internal carotid artery. Mechanical thrombectomy (MT) may benefit patients with TLs; however, optimal management and procedural strategy of the cervical lesion remain unclear.

Objective: To evaluate the association of carotid artery stenting (CAS) vs no stenting and medical management with functional and safety outcomes among patients with TL-LVOs.

Design, setting, and participants: This cross-sectional study included consecutive patients with acute anterior circulation TLs admitted across 17 stroke centers in the US and Spain …

Volume Of Subcortical Brain Regions In Social Anxiety Disorder: Mega-Analytic Results From 37 Samples In The Enigma-Anxiety Working Group, Nynke A. Groenewold, Janna Marie Bas-Hoogendam, Alyssa R. Amod, Max A. Laansma, Laura S. Van Velzen, Moji Aghajani, Kevin Hilbert, Hyuntaek Oh, Ramiro Salas, Anderson M. Winkler

School of Medicine Publications

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven …

Toward A Moral Reckoning On Structural Racism: Examining Structural Factors, Encouraging Structural Thinking, And Supporting Structural Intervention, Shane Mccarty, Megan Liskey, Deepu George, Natalie E. Cook, Jonathan M. Metzl

School of Medicine Publications

The racial reckoning of 2020 involved the largest social movement protest in U.S. history, but support for the Black Lives Matter movement declined shortly after. To advance a moral reckoning on structural racism that dismantles racialized structures and redresses racial inequities, we call on scholar activists within the field of community psychology to realign their own practices by (a) examining structural factors; (b) encouraging structural thinking; and (c) supporting structural intervention for racial justice. Two structural factors–political determinants and commercial determinants–maintain the status quo of structural racism, undermining efforts for racial equity. As a result, we encourage the development of …

Curative Effects Of Triphala Extract Against Swim Stress-Induced Gastric Ulcers Via Reduced Ulcer Index, Strengthened Gastric Mucosa And Improved Redox State In Rats, M Khushtar, H H. Siddiqui, R K. Dixit, Sahir Sultan Alvi

School of Medicine Publications

Recently, the percentage of Peptic ulcer disease not linked to either Helicobacter pylori or non-steroidal anti-inflammatory drugs has increased and signifies the prominent role of psychophysiological stress in the establishment and advancements of gastric ulcers and other peptic ulcer diseases. The current study was intended not only to develop post-treatment swim stress-induced peptic ulcer disease rat model but also to analyze the curative effects of hydro-alcoholic extract of Triphala in swim stress-induced peptic ulcer disease model. A post-treatment swim stress-induced peptic ulcer disease rat model was developed followed by therapeutic intervention of hydro-alcoholic extract of Triphala. The gross evaluation of …