Medicine and Health Sciences Commons^™

Demographic, Clinical, Biomarker, And Neuropathological Correlates Of Posterior Cortical Atrophy: An International Cohort Study And Individual Participant Data Meta-Analysis, Marianne Chapleau, Renaud La Joie, Keir Yong, Federica Agosta, Isabel Elaine Allen, Liana Apostolova, John Best, Baayla D. C. Boon, Sebastian Crutch, Jeremy A. Tanner

School of Medicine Publications

Background

Posterior cortical atrophy is a rare syndrome characterised by early, prominent, and progressive impairment in visuoperceptual and visuospatial processing. The disorder has been associated with underlying neuropathological features of Alzheimer's disease, but large-scale biomarker and neuropathological studies are scarce. We aimed to describe demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy in a large international cohort.

Methods

We searched PubMed between database inception and Aug 1, 2021, for all published research studies on posterior cortical atrophy and related terms. We identified research centres from these studies and requested deidentified, individual participant data (published and unpublished) that had …

Inulin-Based Formulations As An Emerging Therapeutic Strategy For Cancer: A Comprehensive Review, Eswara Naga H K Ghali, Pranav, Subhash Chauhan, Murali M. Yallapu

School of Medicine Publications

Highlights

• Inulin is a naturally occurring prebiotic fiber with therapeutic roles.

• Inulin can act as an excellent carrier for drug delivery in cancer therapy.

• Inulin exhibits an improved therapeutic efficacy in its combination treatments.

• Inulin interventions activate phagocytosis and the TLR4 signaling pathway.

Abstract

Cancer stands as the second leading cause of death in the United States (US). Most chemotherapeutic agents exhibit severe adverse effects that are attributed to exposure of drugs to off-target tissues, posing a significant challenge in cancer therapy management. In recent years, inulin, a naturally occurring prebiotic fiber has gained substantial attention for its potential in …

Therapeutic Potential Of Snake Venom: Toxin Distribution And Opportunities In Deep Learning For Novel Drug Discovery, Anas Bedraoui, Montamas Suntravat, Salim El Mejjad, Salwa Enezari, Naoual Oukkache, Elda E. Sanchez, Jacob Galan, Rachid El Fatimy, Tariq Daouda

School of Medicine Publications

Snake venom is a rich source of bioactive molecules that hold great promise for therapeutic applications. These molecules can be broadly classified into enzymes and non-enzymes, each showcasing unique medicinal properties. Noteworthy compounds such as Bradykinin Potentiating Peptides (BPP) and Three-Finger Toxins (3FTx) are showing therapeutic potential in areas like cardiovascular diseases (CVDs) and pain-relief. Meanwhile, components like snake venom metalloproteinases (SVMP), L-amino acid oxidases (LAAO), and Phospholipase A2s (PLA2) are paving new ways in oncology treatments. The full medicinal scope of these toxins is still emerging. In this review, we discuss drugs derived from snake venoms that address …

Parp Inhibitors In Prostate Cancer – Understanding The Current Landscape, Karine Tawagi, Mia Schmolze, Brandon Nguyen, Aaron A. Laviana, Natalie Reizine

School of Medicine Publications

Poly (ADP [adenosine diphosphate]-ribose) polymerase inhibitors (PARPi) are a current standard of care treatment option for patients with metastatic castration resistant prostate cancer (mCRPC), defined as prostate cancers that continue to progress despite treatment with the usual first-line androgen-deprivation therapies. PARPi’s function by targeting faulty homologous recombination repair pathways that result in cytotoxic double strand DNA break (DSB) accumulation in prostate cancer cells. While the efficacy of PARPi’s as a monotherapy option in mCRCP has been demonstrated clinically, the added utility of PARPi’s in combination with other anti-cancer agents is still being explored. This article will review the scientific rationale …

Perceived Outcomes Of Periacetabular Osteotomy, Ryan Bialaszewski, John M. Gaddis, Bretton Laboret, Elizabeth Bergman, Edward P. Mulligan, Jenny Lacross, Adina Stewart, Joel Wells

School of Medicine Publications

Aims: Social media is a popular resource for patients seeking medical information and sharing experiences. periacetabular osteotomy (PAO) is the gold-standard treatment for symptomatic acetabular dysplasia with good long-term outcomes. However, little is known regarding the perceived outcomes of PAO on social media. The aims of this study were to describe the perceived outcomes following PAO using three social media platforms: Facebook, Instagram, and X (formerly known as Twitter).

Methods: Facebook, Instagram, and X posts were retrospectively collected from 1 February 2023. Facebook posts were collected from the two most populated interest groups: “periacetabular osteotomy” and “PAO Australia.” Instagram and …

X-Chromosome And Kidney Function: Evidence From A Multi-Trait Genetic Analysis Of 908,697 Individuals Reveals Sex-Specific And Sex-Differential Findings In Genes Regulated By Androgen Response Elements, Markus Scholz, Katrin Horn, Janne Pott, Matthias Wuttke, Andreas Kühnapfel, M. Kamal Nasr, Holger Kirsten, Yong Li, Anselm Hoppmann, Mikko Kuokkanen

School of Medicine Publications

X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes …

Hip Preservation Surgery In Patients With Femoroacetabular Impingement Syndrome And Acetabular Dysplasia Improves Functional Measures And Pain Catastrophizing, John M. Gaddis, Rafael De Souza, Benjamin Montanez, Paul A. Nakonezny, Bretton Laboret, Ryan Bialaszewski, Joel Wells

School of Medicine Publications

Background Chronic hip pain is a debilitating condition that severely reduces one's quality of life. Prior studies uncovered a link between hip pathologies and pain catastrophizing, anxiety, and depression. The purpose of this study was to investigate whether hip preservation surgery in patients with femoroacetabular impingement syndrome (FAIS) and acetabular dysplasia (AD) improves functional outcomes and pain catastrophizing. Methods Patients with FAIS and AD were requested to complete a hip questionnaire both preoperatively and postoperatively at a single academic center (University of Texas Southwestern Medical Center, Dallas, Texas, USA). Pain catastrophizing was evaluated using the pain catastrophizing scale, and pain …

Brain-Based Classification Of Youth With Anxiety Disorders: Transdiagnostic Examinations Within The Enigma-Anxiety Database Using Machine Learning, Willem B. Bruin, Paul Zhutovsky, Guido A. Van Wingen, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Kevin Hilbert, Anderson M. Winkler, André Zugman, Federica Agosta, Fredrik Åhs

School of Medicine Publications

Neuroanatomical findings on youth anxiety disorders are notoriously difficult to replicate, small in effect size and have limited clinical relevance. These concerns have prompted a paradigm shift toward highly powered (that is, big data) individual-level inferences, which are data driven, transdiagnostic and neurobiologically informed. Here we built and validated supervised neuroanatomical machine learning models for individual-level inferences, using a case–control design and the largest known neuroimaging database on youth anxiety disorders: the ENIGMA-Anxiety Consortium (N = 3,343; age = 10–25 years; global sites = 32). Modest, yet robust, brain-based classifications were achieved for specific anxiety disorders (panic disorder), but …

A Systems Biology Approach Unveils A Critical Role Of Dpp4 In Upper Gastrointestinal Cancer Patient Outcomes, Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali Yallapu, Manish Tripathi, Meena Jaggi, Subhash Chauhan

School of Medicine Publications

Gastrointestinal (GI) cancers comprise of cancers that affect the digestive system and its accessory organs. The late detection and poor prognosis of GI cancer emphasizes the importance of identifying reliable and precise biomarkers for early diagnosis and prediction of prognosis. The membrane-bound glycoprotein dipeptidyl-peptidase 4 (DPP4), also known as CD26, is ubiquitously expressed and has a wide spectrum of biological roles. The role of DPP4/CD26 in tumor progression in different types of cancers remains elusive. However, the link between DPP4 and tumor-infiltrating cells, as well as its prognostic significance in malignancies, still require further investigation. This study was intended to …

Nonalcoholic Fatty Liver Disease, Liver Fibrosis, And Structural Brain Imaging: The Cross-Cohort Collaboration, Galit Weinstein, Adrienne O'Donnell, Stefan Frenzel, Tian Xiao, Amber Yaqub, Pinar Yilmaz, Robert J. De Knegt, Gladys E. Maestre, Debora Melo Van Lent, Michelle Long

School of Medicine Publications

Background and purpose

Prior studies reported conflicting findings regarding the association of nonalcoholic fatty liver disease (NAFLD) and liver fibrosis with measures of brain health. We examined whether NAFLD and liver fibrosis are associated with structural brain imaging measures in middle- and old-age adults.

Methods

In this cross-sectional study among dementia- and stroke-free individuals, data were pooled from the Offspring and Third Generation cohorts of the Framingham Heart Study (FHS), the Rotterdam Study (RS), and the Study of Health in Pomerania. NAFLD was assessed through abdominal imaging. Transient hepatic elastography (FibroScan) was used to assess liver fibrosis in FHS and …

Higher Procedural Volumes Are Associated With Faster Treatment Times, Better Functional Outcomes, And Lower Mortality In Patients Undergoing Endovascular Treatment For Acute Ischemic Stroke, Raul G. Nogueira, Diogo C. Haussen, Eric E. Smith, Jie-Lena Sun, Ying Xian, Brooke Alhanti, Rosalia Blanco, Brian Mac Grory, Mohamed F. Doheim, Ameer E. Hassan

School of Medicine Publications

Objective We aimed to characterize the association of hospital procedural volumes with outcomes among acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT).

Methods This was a retrospective, observational cohort study using data prospectively collected from January 1, 2016, to December 31, 2019, in the Get With The Guidelines-Stroke registry. Participants were derived from a cohort of 60,727 AIS patients treated with EVT within 24 hours at 626 hospitals. The primary cohort excluded patients with pretreatment NIHSS6 hours, and inter-hospital transfers. There were two secondary cohorts: (1) EVT metrics cohort: excluded patients with missing data on time from door-to-arterial-puncture; (2) …

A Social Media Analysis Of Patient-Perceived Complications Following Periacetabular Osteotomy (Pao): A Retrospective Observational Study, Bretton Laboret, Ryan Bialaszewski, John M. Gaddis, Emily Middleton, Brittany Kendall, Katie Lynch, Adina Stewart, Joel Wells

School of Medicine Publications

Background: Social media is a popular resource for patients seeking medical information and sharing experiences. Periacetabular osteotomy (PAO) is an accepted treatment for symptomatic acetabular dysplasia with a low published complication profile in specialty centers. Little is known regarding patient reporting of complications on social media following PAO. The purpose of this study was to describe the patient-perceived complications of PAO posted on social media and analyze how additional factors (postoperative timeframe, concomitant surgery) correlate with these complication posts.

Methods: Facebook and Instagram were queried from 02/01/18-02/01/23; Twitter was searched over an extended range back to 02/01/11. Facebook posts (1054) …

P513: Project Give: Expanding Genetic Testing To Underserved Areas In The Rio Grande Valley Using An Ehr-Agnostic Tele-Engagement Platform, Blake Vuocolo, Roberta Sierra, Kent Carter, Keila Rodriguez, Lori Berry, Ana Hernandez, Humberto Hidalgo, Alberto Allegre, Sandy Magallan, Sarah Rodriguez

School of Medicine Publications

Introduction

Providing an accurate genetic diagnosis to children in a timely manner is crucial for providing appropriate medical interventions, counseling families about recurrence risks, and addressing the psychosocial and financial challenges that are known to be associated with diagnostic odysseys. Unfortunately, underserved and under resourced areas across the nation have poor access to genetic testing. There is a significant disparity in access to genomic healthcare in the Rio Grande Valley (RGV) along the Texas-Mexico border, which has a population of about 1.4 million residents and no local full-time genetics provider. Over 94% of the population in the RGV is Hispanic, …

Trans-Ancestry Analysis Of Psychosis Biotypes: Shared Polygenic Risk And Unique Genomic Associations, Elliot S. Gershon, Ney Alliey-Rodriguez, Carol A. Tamminga, Matcheri S. Keshavan, Godfrey D. Pearlson, Sarah K. Keedy, David Parker, Rebekka Lencer, Scot Hill, Jeffrey R. Bishop

School of Medicine Publications

The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) has categorized psychosis disorders (Schizophrenia, Schizoaffective Disorder and Bipolar Disorder) into three distinct Biotypes, based on neurobiological measurements in a multi-ancestry sample. Two recently developed post hoc ancestry adjustment methods of Polygenic Risk Scores (PRSs) generate Trans-Ancestry PRSs (TAPRSs), which allow for PRS analysis of multi-ancestry samples. Applied to schizophrenia PRS, we found the Khera TAPRS method to show superior portability and comparable prediction accuracy as compared with the Ge method. The three Biotypes of psychosis disorders had similar TAPRSs across ancestries. In genomic analysis of Biotypes, nine genes and isoforms showed significant …

Nanopore-Based Dna Long-Read Sequencing Analysis Of The Aged Human Brain, Paulino Ramirez, Wenyan Sun, Shiva Kazempour Dehkordi, Habil Zare, Bernard Fongang, Kevin F. Bieniek, Bess Frost

School of Medicine Publications

Aging disrupts cellular processes such as DNA repair and epigenetic control, leading to a gradual buildup of genomic alterations that can have detrimental effects in post-mitotic cells. Genomic alterations in regions of the genome that are rich in repetitive sequences, often termed "dark loci," are difficult to resolve using traditional sequencing approaches. New long-read technologies offer promising avenues for exploration of previously inaccessible regions of the genome. Using nanopore-based long-read whole-genome sequencing of DNA extracted from aged 18 human brains, we identify previously unreported structural variants and methylation patterns within repetitive DNA, focusing on transposable elements ("jumping genes") as crucial …

Cognitive, Behavioral, And Circadian Rhythm Interventions For Insomnia Alter Emotional Brain Responses, Jeanne Leerssen, Moji Aghajani, Tom Bresser, Lara Rösler, Anderson M. Winkler, Jessica C. Foster-Dingley, Eus J.W. Van Someren

School of Medicine Publications

Background

Methods

False Discovery Rate And Localizing Power, Anderson M. Winkler, Paul A. Taylor, Thomas E. Nichols, Chris Rorden

School of Medicine Publications

False discovery rate (FDR) is commonly used for correction for multiple testing in neuroimaging studies. However, when using two-tailed tests, making directional inferences about the results can lead to vastly inflated error rate, even approaching 100% in some cases. This happens because FDR only provides weak control over the error rate, meaning that the proportion of error is guaranteed only globally over all tests, not within subsets, such as among those in only one or another direction. Here we consider and evaluate different strategies for FDR control with two-tailed tests, using both synthetic and real imaging data. Approaches that separate …

Peripartum Cardiomyopathy; Understanding And Improving Outcomes-A Systematic Review, Shakirat Ganiyu, Taiwo Akeem Lawal, Sarah Petrie

School of Medicine Publications

Background: Peripartum cardiomyopathy (PPCM) presents a significant global health challenge, contributing substantially to maternal morbidity and mortality worldwide. Despite ongoing research efforts, the multifaceted nature of PPCM, encompassing genetic, environmental, and clinical factors, necessitates a comprehensive understanding to improve patient outcomes effectively.

Aims: This systematic review aims to synthesise current knowledge on PPCM aetiology, risk factors, diagnosis, therapeutic interventions, and prognostic indicators, highlighting recent advancements and potential avenues for future research and clinical management. By addressing key aspects such as genetic predispositions, environmental influences, diagnostic strategies, therapeutic modalities, and global disparities, this review seeks to provide insights that can inform …

Novel Method Of Isolating Nuclei Of Human Oligodendrocyte Precursor Cells Reveals Substantial Developmental Changes In Gene Expression And H3k27ac Histone Modification, Alexey Kozlenkov, Ramu Vadukapuram, Ping Zhou, Peter Fam, Michael Wegner, Stella Dracheva

School of Medicine Publications

Oligodendrocyte precursor cells (OPCs) generate differentiated mature oligodendrocytes (MOs) during development. In adult brain, OPCs replenish MOs in adaptive plasticity, neurodegenerative disorders, and after trauma. The ability of OPCs to differentiate to MOs decreases with age and is compromised in disease. Here we explored the cell specific and age-dependent differences in gene expression and H3K27ac histone mark in these two cell types. H3K27ac is indicative of active promoters and enhancers. We developed a novel flow-cytometry-based approach to isolate OPC and MO nuclei from human postmortem brain and profiled gene expression and H3K27ac in adult and infant OPCs and MOs genome-wide. …

Iuphar Review- Preclinical Models Of Neuropathic Pain: Evaluating Multifunctional Properties Of Natural Cannabinoid Receptors Ligands, Khalid Benamar

School of Medicine Publications

Neuropathic pain remains prevalent and challenging to manage and is often comorbid with depression and anxiety. The new approach that simultaneously targets neuropathic pain and the associated comorbidities, such as depression and anxiety, is timely and critical, given the high prevalence and severity of neuropathic pain and the lack of effective analgesics. In this review, we focus on the animal models of neuropathic pain that researchers have used to investigate the analgesic effects of cannabidiol (CBD) and Beta-Caryophyllene (BCP) individually and in combination while addressing the impact of these compounds on the major comorbidity (e.g., depression, anxiety) associated with neuropathic …

Editorial: Genome-Wide Molecular Mechanisms Of Substance Use Disorders, Ilya O. Blokhin, David M. Martinez-Garza, Dhruti Patel, Antoine B. Douaihy, Ihsan M. Salloum

School of Medicine Publications

No abstract provided.

Annotated Bibliography On The Mechanism Starting And Sustaining Atherosclerosis, Dat H. Pham, Thach Nguyen, Hao Thuy Nguyen, Marco Zuin, Duc Khiem Ngo, Hadrian Tran, Nhat H. Pham, Thinh T. Nguyen, Chau Dang, Pham Tv Le

School of Medicine Publications

Background: In the past 30 years, there has been a significant rise in coronary artery disease (CAD) and atherosclerosis, primarily attributed to dietary changes toward cholesterol-rich fast foods. Traditional research methodologies focusing on molecular biology have been insufficient in fully understanding the initiation mechanisms of these conditions. This paper reviews the literature and defines the knowledge gap for the need for a new dynamic coronary angiographic technique.

Methods: Our approach involved a comprehensive review of fluid mechanics literature to identify gaps in current CAD research. This included analyzing major works from standard physiology textbooks, fluid mechanics reviews, and bioengineering …

Preliminary Results Of A Study Using Dynamic Angiography In Predicting Progression Or Regression Of Moderate Severity Lesions, Thach Nguyen, Marco Zuin, Pham Tv Le, Vinh Sieu Lam, Hien Q. Nguyen, Hung V. Dang, Huyen K. Huynh, Duc Khiem Ngo, Thinh T. Nguyen, Imran Mihas

School of Medicine Publications

Background: Many patients with stable angina (SA) having moderate 50% lesions could deteriorate or stay stable for a long time. No present techniques nor test could accurately predict the progression to acute coronary syndrome (ACS) or stabilization of these moderate lesions. Based on the fluid dynamic methodology research, could turbulent flow further damage the plaque and rupture its cap? In contrast, could laminar flow delay the progression of the plaque and keep patients stable for a long period of time?

Methods: Patients with stable angina (SA) were admitted to the intermediate care unit and underwent coronary angiography. Patients were selected …

Ceacam7 Expression Contributes To Early Events Of Pancreatic Cancer, Anupam Dhasmana, Swati Dhasmana, Sudhir Kotnala, Partha Laskar, Sheema Khan, Shafiul Haque, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

Highlights

• The trends of pancreatic cancer (PanCa) incidence and mortality are on rising pattern, and it will a second leading cause of cancer related deaths by 2030.
• Approximately 85–90% PanCa are pancreatic ductal adenocarcinoma (PDAC), which is one of the most challenging and aggressive malignancy.
• PDAC exhibits with grim prognosis as mortality rate is very close to the incidence due lack of early detection methods and effective therapeutic regimen.
• Our team has identified a novel oncogenic protein, carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7), that can be useful for early PDAC diagnosis and predictor of patient survival.
• We also observed …

Focal Adhesion Is Associated With Lithium Response In Bipolar Disorder: Evidence From A Network-Based Multi-Omics Analysis, Vipavee Niemsiri, Sara Brin Rosenthal, Caroline M. Nievergelt, Adam X. Maihofer, Maria C. Marchetto, Renata Santos, Tatyana Shekhtman, Ney Alliey-Rodriguez, Amit Anand, Yokesh Balaraman

School of Medicine Publications

Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and pathways that distinguish BD Li responders (LR) from BD Li non-responders (NR). An initial Pharmacogenomics of Bipolar Disorder study (PGBD) GWAS of lithium response did not provide any significant results. As a result, we then employed network-based integrative analysis of transcriptomic and genomic data. In transcriptomic study of iPSC-derived neurons, 41 significantly differentially expressed (DE) genes were identified in LR vs NR regardless …

Multicentric Assessment Of A Multimorbidity-Adjusted Disability Score To Stratify Depression-Related Risks Using Temporal Disease Maps: Instrument Validation Study, Rubèn González-Colom, Kangkana Mitra, Emili Vela, Andras Gezsi, Teemu Paajanen, Zsófia Gál, Gabor Hullam, Hannu Mäkinen, Tamas Nagy, Mikko Kuokkanen

School of Medicine Publications

Background: Comprehensive management of multimorbidity can significantly benefit from advanced health risk assessment tools that facilitate value-based interventions, allowing for the assessment and prediction of disease progression. Our study proposes a novel methodology, the Multimorbidity-Adjusted Disability Score (MADS), which integrates disease trajectory methodologies with advanced techniques for assessing interdependencies among concurrent diseases. This approach is designed to better assess the clinical burden of clusters of interrelated diseases and enhance our ability to anticipate disease progression, thereby potentially informing targeted preventive care interventions.

Objective: This study aims to evaluate the effectiveness of the MADS in stratifying patients into clinically relevant risk …

Riemannian Frameworks For The Harmonization Of Resting-State Functional Mri Scans, Nicolas Honnorat, Sudha Seshadri, Ron Killiany, John Blangero, David C. Glahn, Peter T. Fox, Mohamad Habes

School of Medicine Publications

Magnetic Resonance Imaging provides unprecedented images of the brain. Unfortunately, scanners and acquisition protocols can significantly impact MRI scans. The development of statistical methods able to reduce this variability without altering the relevant information in the scans, often coined harmonization methods, has been the topic of an increasing research effort supported by the recent growth of publicly available neuroimaging data sets and new possibilities for combining them to achieve greater statistical power. In this work, we focus on the challenges specifically raised by the harmonization of resting-state functional MRI scans. We propose to harmonize resting-state fMRI scans by reducing the …

Targeting Of Oncogenic Aaa-Atpase Trip13 Reduces Progression Of Pancreatic Ductal Adenocarcinoma, Farrukh Afaq, Sumit Agarwal, Prachi Bajpai, Sameer Al Diffalha, Hyung-Gyoon Kim, Shajan Peter, Moh'd Khushman, Subhash Chauhan, Priyabrata Mukherjee, Sooryanarayana Varambally, Upender Manne

School of Medicine Publications

Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression, but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the expression, functional role, and mechanism of action of TRIP13 in PDAC. We further examined the efficacy of TRIP13 inhibitor, DCZ0415, alone or in combination with gemcitabine on malignant phenotypes, tumor progression, and immune response. We found that TRIP13 was overexpressed in human PDACs relative to corresponding normal pancreatic tissues. TRIP13 knockdown or treatment of PDAC cells with DCZ0415 reduced proliferation and colony formation, and induced G2/M cell cycle arrest and apoptosis. Additionally, TRIP13 knockdown …

Bridging Bone Health: Osteoporosis Disparities In The Rio Grande Valley, Ryan P. Bialaszewski, John M. Gaddis, Blake Martin, Philippe J. Dentino, John Ronnau

School of Medicine Publications

Introduction: Osteoporosis is characterized by decreased bone mass and decreased bone quality, leading to increased bone fragility and risk of fractures. The number of fractures due to osteoporosis is projected to increase to over three million by the year 2025 and cost $25.3 billion annually. It ranks highly among diseases that cause patients to become bedridden with serious complications and reduced quality of life. Additionally, osteoporosis disproportionately affects Hispanics, which comprise most of the Rio Grande Valley (RGV) population. Therefore, our primary objective was to determine the prevalence of osteoporosis within the RGV. Additionally, we had secondary objectives to determine …

Covid-19 May Have A Detrimental Impact On Sensorimotor Function, Monica Goss, Rebecca Bernal, Vibhuti N. Patel, Karl Li, Valentina R. Garbarino, Rejani R. Nair, Heather Snyder, Gabriel A. De Erausquin, Mary Ganguli, Beth E. Snitz, Timothy D. Girard

School of Medicine Publications

Background: The long-term impact of COVID-19 on global health is still unknown. Sensorimotor biomarkers may be promising indicators of lasting effects of COVID-19. Although normal aging may cause changes in sensorimotor function, more severe changes may indicate the subsequent impacts of COVID-19 on brain health. The objective of this study was to investigate the association between COVID-19 and sensorimotor markers (grip strength, gait, and smell) in the 7T neuroCOVID consortium, which is comprised of 5 sites: The University of Texas Health Science Center at San Antonio, Houston Methodist Research Institute, The University of Pittsburgh, Massachusetts General Hospital, and Nottingham University …