Medicine and Health Sciences Commons^™

Validation Of A Brief Food Parenting Measure For Fathers: A Test Of Factorial Validity, Measurement Invariance, Internal Reliability, And Concurrent Validity, Brian K. Lo, In Young Park, Melissa Mcternan, Yilin Wang, Alejandra Cantu-Aldana, Brent A. Mcbride, Katherine W. Bauer, Jess Haines, Kirsten K. Davison

School of Medicine Publications

Fathers are underrepresented in food parenting research partly due to the lack of succinct, theory-informed, and father-mother equivalent food parenting measurement tools. To address this, we 1) tested the factorial validity of a brief food parenting measure utilizing a subset of items from the Comprehensive Feeding Practices Questionnaire (CFPQ) to represent coercive control, structure, and autonomy support, 2) assessed the extent to which the brief tool works similarly in fathers and mothers (i.e., measurement invariance), and 3) evaluated its internal reliability and concurrent validity. Participants included 1071 fathers of children aged 2–6 years and 487 of their co-parents (mothers) from …

Predictors Of Bi-Directional Transitions From Mild Cognitive Impairment In A Diverse Cohort, Mitzi M. Gonzales, Roman Fernandez, Sarah Kremen, Zaldy S. Tan, Amy E. Werry, Xueqiu Jian, John Hart, Donald Royall, Gladys Maestre, Sara Espinoza

School of Medicine Publications

Trajectories following a diagnosis of mild cognitive impairment (MCI) are varied and may fluctuate over time. Among diverse ethnic and racial groups, social factors, medical comorbidities, and biases in assessment procedures may contribute to greater heterogeneity in the MCI diagnostic category and affect its prognostic significance for dementia. The study goal was to evaluate the frequency and variables associated with MCI transitions among non-Hispanic White (NHW) and Latinx older adults. Multistate Markov models characterized transitions across diagnostic states (cognitively unimpaired (CU), MCI, dementia) over ten years. Variables associated with transitions were assessed using hazard ratios (HR) and 95% confidence intervals …

The Internist's Post V.1 N.12, The University Of Texas Rio Grande Valley. School Of Medicine, Eunbee Cho, Jian Garcia Cruz, Ramon Elizondo Romo, Barbara Malaga-Espinoza, Carlos Alejos Aguero, Osiris Fernandez, Roque Mifuji Lira, Martha Solis, Cesar Gutierrez

School of Medicine Publications

No abstract provided.

Gout Versus Pseudogout In The Medically Underserved Rio Grande Valley, Blake Martin, Fernando Cisneros, Kristina Vatcheva, Michael Sander

School of Medicine Publications

Background

Gout and pseudogout are inflammatory joint conditions, with gout being one of the most prevalent etiologies of chronic inflammatory arthritis in the United States. The patient population in the Rio Grande Valley (RGV) has a distinct demographic profile that warrants the exploration of various health conditions. The primary objective of this study was to expand the knowledge of orthopedics and determine if there were demographic disparities between gout and pseudogout in this community. We hypothesized that there would be demographic disparities between gout and pseudogout depending on age, sex, and ethnicity.

Methods

This was a retrospective chart review, and …

Osteoporosis In Relation To A Bone-Related Aging Biomarker Derived From The Urinary Proteomic Profile: A Population Study, Yu-Ling Yu, Dries S. Martens, De-Wei An, Babangida Chori, Agnieszka Latosinska, Justyna Siwy, Augustine N. Odili, Katarzyna Stolarz-Skrzypek, Gladys E. Maestre, Kei Asayama

School of Medicine Publications

Screening for and prevention of osteoporosis and osteoporotic fractures is imperative, given the high burden on individuals and society. This study constructed and validated an aging-related biomarker derived from the urinary proteomic profile (UPP) indicative of osteoporosis (UPPost-age). In a prospective population study done in northern Belgium (1985-2019), participants were invited for a follow-up examination in 2005-2010 and participants in the 2005-2010 examination again invited in 2009-2013. Participants in both the 2005-2010 and 2009-2013 examinations (n = 519) constituted the derivation (2005-2016 data) and time-shifted validation (2009-2013 data) datasets; 187 participants with only 2005-2010 data formed the synchronous validation dataset. …

Understanding Hip Pain Through Social Media: An Initial Overview Of An International Web-Based Survey, John M. Gaddis, Erika Shults, Bretton Laboret, Ryan Bialaszewski, Katerina Wells, Charles South, Joel Wells

School of Medicine Publications

Background: We aimed to understand the adult experience of hip pain through a web-based REDCap platform via social media. The purpose of this study was to assess the possibility of collecting patient-reported data through social media in people with hip pain while outlining the contents of the survey and analyzing the demographics of the sample population.

Methods: The survey link was active from October 1, 2023, to May 1, 2024, and available on social media platforms. Respondents provided consent prior to survey participation. Responses were anonymous, and only unique, fully complete surveys were analyzed. The comprehensive hip survey included demographic …

Trastornos Neurocognitivos, Depresión Y Factores Sociodemográficos En Habitantes De La Orinoquía-Amazonía De Colombia: Análisis Secundario Del Estudio Sabe [Neurocognitive Disorders, Depression, And Sociodemographic Factors In Residents Of The Orinoquia-Amazon Region Of Colombia: Secondary Analysis Of The Sabe Study], Maria Del Pilar Santacruz-Ortega, Bertha Lucia Avendaño-Prieto, Sonia Gisela Rios Cruz, Silvia Mejia-Arango

School of Medicine Publications

A partir de un análisis secundario de los datos derivados del estudio SABE Colombia 2015, con 1394 adultos de 60 años o más, se identificó el papel mediador de diferentes variables sociodemográficas y de calidad de vida en la relación entre depresión y trastornos cognoscitivos (leve y demencia) en el adulto mayor residente en la región de la Orinoquía-Amazonía de Colombia. Las asociaciones entre las variables de estudio (depresión y trastornos cognoscitivos) se establecieron con la prueba chi cuadrado, cuyo valor y significancia fueron χ² = 230.2 y p = .00. Los análisis de mediación se realizaron con el programa …

Kras Mutations In Cancer: Understanding Signaling Pathways To Immune Regulation And The Potential Of Immunotherapy, Priyanka Uniyal, Vivek Kumar Kashyap, Tapan Behl, Deepak Parashar, Ravi Rawat

School of Medicine Publications

The Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation is one of the most prevailing mutations in various tumors and is difficult to cure. Long-term proliferation in carcinogenesis is primarily initiated by oncogenic KRAS-downstream signaling. Recent research suggests that it also activates the autocrine effect and interplays the tumor microenvironment (TME). Here, we discuss the emerging research, including KRAS mutations to immune evasion in TME, which induce immunological modulation that promotes tumor development. This review gives an overview of the existing knowledge of the underlying connection between KRAS mutations and tumor immune modulation. It also addresses the mechanisms to reduce …

Task-Rest Reconfiguration Efficiency Of The Reward Network Across Adolescence And Its Association With Early Life Stress And Depressive Symptoms, Yoonji Lee, Justin P. Yuan, Anderson M. Winkler, Katharina Kircanski, Daniel Samuel Pine, Ian H. Gotlib

School of Medicine Publications

Objective

Adolescents face significant changes in many domains of their daily lives that require them to flexibly adapt to changing environmental demands. To shift efficiently among various goals, adolescents must reconfigure their brains, disengaging from previous tasks and engaging in new activities.

Method

To examine this reconfiguration, we obtained resting-state and task-based fMRI scans in a community sample of 164 adolescents. We assessed the similarity of functional connectivity (FC) of the reward network between resting state and a reward processing state, indexing the degree of reward network reconfiguration required to meet task demands. Given research documenting relations among reward network …

Non-Achievement Of Low-Density Lipoprotein Cholesterol Goal And Related Factors Among Elderly Outpatients In Viet Nam: A Cross-Sectional Study, Dung Si Ho, Teo Van Le, Hung Cao Dinh, Thach Nguyen, Duc Khiem Ngo, Cong Duc Nguyen

School of Medicine Publications

Introduction: Dyslipidemia, particularly elevated serum low-density lipoprotein cholesterol (LDL-C), plays a crucial role in the development and progression of atherosclerosis. This study aimed to determine the rate of LDL-C non-achievement according to the European Society of Cardiology/European Atherosclerosis Society 2019 (ESC/EAS 2019) guidelines and related factors in the elderly.

Methods: This was a cross-sectional study involving 555 individuals (age 69.30 ± 6.54, male/female ratio 4.55/1) in an outpatient clinic in Ca Mau province from October 2020 to June 2021. Demographic information, medical history, clinical characteristics, and tested cholesterol, including LDL-C level, were collected to assess cardiovascular risk and determine factors …

Return To Basketball For College And Professional Athletes After Surgical Repair Of Achilles Tendon, Paul Bonilla, Hunter M. Butler, Aasim Ahmad, Aamir Ahmad

School of Medicine Publications

Background: Basketball places extreme mechanical stress on an athlete’s body, leading to a variety of injuries within the sport. Achilles tendon (AT) ruptures have started to garner attention as the incidence of this season ending injury continues to increase [1]. AT ruptures have also been shown to have a higher prevalence in basketball compared to other sport populations. [2]. With the recovery time of AT ruptures being a minimum of 6 months, and data supporting a decrease in player performance and career longevity, it is important to understand the indicated pathophysiology behind the injury along with the surgical management options …

Minerals And Human Health: From Deficiency To Toxicity, Mohammed S. Razzaque, Sunil J. Wimalawansa

School of Medicine Publications

Minerals are essential nutrients that play critical roles in human health by regulating various physiological functions. Examples include bone development, enzyme function, nerve signaling, and the immune response. Both the deficiencies and toxicities of minerals can have significant health implications. Deficiencies in macrominerals such as calcium, magnesium, and phosphate can lead to osteoporosis (associated with falls and fractures), cardiovascular events, and neuromuscular dysfunction. Trace mineral deficiencies, such as iron and zinc. Selenium deficiency impairs oxygen transport, immune function, and antioxidant defenses, contributing to anemia, delaying wound healing, and increasing susceptibility to infectious diseases. Conversely, excessive intake of minerals can have …

Collateral Rescue, Arterial Burden: Untreated Takayasu Arteritis And Its Long-Term Complications, Ikwinder Preet Kaur, Steven Morales-Rivera, Victoria Cuello, Gurjit S. Kaeley

School of Medicine Publications

No abstract provided.

Active Learning In Medical Education: A Brief Overview Of Its Benefits, Varuneshwar Parsad, Jeevan Divakaran

School of Medicine Publications

The traditional lecture-based model of medical education is increasingly being replaced by active learning methodologies that focus on interactive, student-centered approaches to enhance knowledge retention, clinical reasoning, and professional development. This brief review highlights the benefits of active learning techniques such as problem-based learning (PBL), team-based learning (TBL), case-based learning (CBL), and simulation-based learning (SBL) in medical education. These active learning methods promote a deeper understanding and application of medical knowledge, improve clinical reasoning, increase student engagement and motivation, and foster the development of interpersonal skills essential for healthcare practice. Furthermore, active learning bridges the gap between theoretical knowledge and …

Editorial: Vitamin D And Mineral Ion Homeostasis: Endocrine Dysregulation In Chronic Diseases, Rahnuma Ahmad, Bara Sarraj, Mohammed S. Razzaque

School of Medicine Publications

No abstract provided.

Pattern Integration And Differentiation: Dual Process Model Of Episodic Memory, Hallvard Røe Evensmoen, Lars M. Rimol, Henning Stople Rise, Tor Ivar Hansen, Hamed Nili, Anderson M. Winkler, Asta K. Håberg

School of Medicine Publications

The role of precise timing in episodic memory remains obscure. We showed 139 participants episodes consisting of objects, and tested subsequent memory for the precise timing and order of the objects and episodes. Temporal compression of the episode enhanced memory for relative but not absolute timing of the objects’ presentation and their order. Conversely, temporal expansion between neighboring episodes was associated with successful memory for episode order. fMRI in 36 participants revealed that temporal compression of the episode was associated with more similar activation patterns within episodes in several brain regions including the posterior hippocampus. However, the activation pattern in …

A Handheld Uv-C Light-Emitting Diode Decreases Environmental Contamination Near The Operative Field, Rachael A. Turner, Roseann M. Johnson, Yasmin Yazdani-Farsad, Jessell Owens, Douglas A. Dennis, Jason M. Jennings

School of Medicine Publications

Introduction: Periprosthetic joint infection (PJI) may result from pathogen-to-patient transmission within the environment. High-touch surfaces (HTS) areas near the operative field from previous studies had been identified as the least likely to be thoroughly cleaned between operative cases and were utilized for this study. The purpose of this study was to assess the impact of a handheld ultraviolet-c (UV-C) lightemitting diode (LED) disinfection device on the decontamination of HTS in the operating room.

Methods: This prospective study was conducted between 03/02/2021 and 04/20/2021. Tryptic soy agar contact plates were used to determine the bacterial load of the selected surfaces before …

Multi Site Comparison Of Participant Profiles In The South Texas Alzheimer’S Disease Research Center, Jennifer G. Del Bosque, Chen-Pin Wang, Roman F. Fernandez, Jeremy A. Tanner, A. Campbell Sullivan, Sarah E. Savoia, Rosa V. Pirela, Silvia Mejia-Arango, Gladys Maestre, Sudha Seshadri

School of Medicine Publications

Background

Hispanic adults comprise 19% of the US population, yet 400% increase in ADRDs in this population is anticipated over the next twenty-five years. Knowledge is limited on the prevalence and influence of social determinants of health (SDoH) and modifiable risk factors on cognition in ethnically diverse groups. The South Texas Alzheimer’s Disease Research Center (STAC, P30AG066546) is a collaboration between UT Health San Antonio (UTHSA) and UT Rio Grande Valley (UTRGV) with a primary aim to better understand ADRDs in Hispanic adults. Our objective is (1) to describe differences in SDoH, modifiable risk factors, and cognitive performance in cognitively …

Macrowire For Intracranial Thrombectomy: An Early Experience Of A New Device And Technique For Anterior Circulation Large Vessel Occlusion Stroke, Kaustubh Limaye, Sami Al Kasab, Jaidevsinh Dolia, Mohamad Ezzeldin, Daniel Vela Duarte, Vinodh Doss, Sourabh Lahoti, David Hasan, Alejandro Spiotta, Ameer E. Hassan

School of Medicine Publications

Background and Purpose

Mechanical thrombectomy (MT) has become the standard of care for treatment of acute ischemic stroke secondary to large vessel occlusion up to 24 h from the last known normal time. With ADAPT and SOLUMBRA techniques, classically, a large bore aspiration catheter is delivered over a microcatheter and microwire crossing the clot to perform thrombectomy. Recently, a novel macrowire (Colossus 035 in.) has been introduced as a potential alternative to the use of microwire-microcatheter to allow the delivery of the aspiration catheter (ID = 0.070 in. up to 0.088 in.) over a macrowire alone.

Objective

To test the …

Integrated Multi-Omics Analyses Of Synaptosomes Revealed Synapse-Associated Novel Targets In Alzheimer’S Disease, Subodh Kumar, Enrique Ramos, Axel Hidalgo, Daniela Rodarte, Bhupender Sharma, Melissa M. Torres, Davin Devara, Shrikanth Gadad

School of Medicine Publications

Synapse dysfunction is an early event in Alzheimer’s disease (AD) caused by various factors, including amyloid beta, p-tau, inflammation, and aging. However, the precise molecular mechanism underlying synapse dysfunction in AD remains largely unknown. To understand this, we comprehensively analyzed the synaptosomes fraction in post-mortem brain samples from AD patients and cognitively normal individuals. We conducted high-throughput transcriptomic analyses to identify changes in microRNA (miRNA) and mRNA levels in synaptosomes extracted from the brains of unaffected individuals and those with AD. Additionally, we performed mass spectrometry analysis of synaptosomal proteins in the same sample group. These analyses revealed significant differences …

Clinical Relapse Versus Treatment Failure: The Case For Surveillance For Re-Appearance Of Minimal Measurable Disease In Pediatric Patients With Higher Risk B-All, Paul S. Gaynon, Linwei Li

School of Medicine Publications

No abstract provided.

Genetic Associations Among Inflammation, White Matter Architecture, And Extracellular Free Water, Amanda L. Rodrigue, Emma M. Knowles, Josephine Mollon, Samuel R. Mathias, Juan M. Peralta, Ana C. Leandro, Peter T. Fox, Peter Kochunov, Rene L. Olvera, Laura Almasy, Joanne E. Curran, John Blangero, David C. Glahn

School of Medicine Publications

Phenotypic and genetic relationships between white matter microstructure (i.e., fractional anisotropy [FA]) and peripheral inflammatory responses (i.e., circulating cytokines) have important implications for health and disease. However, it is unclear whether previously discovered genetic correlations between the two traits are due to tissue‐specific white matter architecture or increased free water in the extracellular space. We applied a two‐compartment model to diffusion tensor imaging (DTI) data and estimated tissue‐specific white matter microstructure (FAT) and free water volume (FW). We then quantified their heritability and their genetic correlations with two peripherally circulating proinflammatory cytokines (IL‐8 and TNFα), and compared these correlations to …

General Kernel Machine Methods For Multi-Omics Integration And Genome-Wide Association Testing With Related Individuals, Amarise Little, Ni Zhao, Anna Mikhaylova, Angela Zhang, Wodan Ling, Florian Thibord, Andrew D. Johnson, Laura M. Raffield, Joanne E. Curran, John Blangero

School of Medicine Publications

Integrating multi-omics data may help researchers understand the genetic underpinnings of complex traits and diseases. However, the best ways to integrate multi-omics data and use them to address pressing scientific questions remain a challenge. One important and topical problem is how to assess the aggregate effect of multiple genomic data types (e.g. genotypes and gene expression levels) on a phenotype, particularly while accommodating routine issues, such as having related subjects' data in analyses. In this paper, we extend an existing composite kernel machine regression model to integrate two multi-omics data types, while accommodating for general correlation structures amongst outcomes. Due …

Sex Differences In Inter-Temporal Decision Making And Cortical Thickness Of The Orbitofrontal And Insula In Young Adult Cannabis Users: Evidence From 1111 Subjects, Alan N. Francis, Joan A. Camprodon, Francesca Filbey

School of Medicine Publications

To test for sex differences in the impact of cannabis use on decision-making and brain correlates, we employed cortical thickness (CT) analysis of brain regions involved in intertemporal decision-making namely bilateral orbitofrontal cortex(OFC) and insula in young adult nondependent cannabis-users(CU) and non-users(NU) and their scores on delay discounting task. Neuroimaging analyzes of previously collected data were performed on 608CU and 503NU. CT analysis was performed on MRI images. OFC and insula thickness, scores on the delay discounting test were compared between groups and correlated. Controlling alcohol-use and intra-cranial-volume, CU exhibited sex differences in CT. The bilateral insula was significantly thinner …

Large‐Vessel Occlusion Stroke Knowledge And Training For Stroke Severity Assessment Among Emergency Medical Services Personnel In The United States, Kaiz S. Asif, Robin Novakovic, Thanh N. Nguyen, Santiago Ortega‐Gutierrez, Youngran Kim, Amanda Jagolino‐Cole, Sushanth Aroor, Alicia Castonguay, Prateek Kumar, Ameer E. Hassan

School of Medicine Publications

Background

Prehospital identification of large‐vessel occlusion (LVO) stroke facilitates the development of a regional triage protocol that could lead to an improvement in intrahospital and interhospital workflows. This requires stroke education of emergency medical services (EMS) personnel to improve stroke recognition, severity assessment, and prenotification. However, the current state of EMS personnel's knowledge of LVO stroke, their training for stroke severity assessment, and their preferences for educational methods are unknown. We conducted a nationwide EMS survey across the United States to glean insights that can inform and customize future EMS educational efforts.

Methods

The Society of Vascular and Interventional Neurology, …

The Internist's Post V.1 N.11, The University Of Texas Rio Grande Valley. School Of Medicine, Eunbee Cho, Osiris Fernandez, Hector D. Preciado, Sobia Memon, Diana Acosta Pozo, Corey Haines, Roque Mifuji Lira, Martha Solis, Cesar Gutierrez

School of Medicine Publications

No abstract provided.

La Disfunción Autonómica En La Enfermedad Por Reflujo Gastroesofágico. El Eje Neurogastro-Cardiaco: ¿Amigo O Enemigo?, Sergio Sobrino-Cossio, Jorge Cossío-Aranda, Elymir Soraya Galvis-García, Gualberto Mateos-Pérez, Óscar Teramoto-Matsubara, Jesús A. González-Hermosillo, Juan Carlos López-Alvarenga, Mustafa Azizoglu, José M. Remes-Troche

School of Medicine Publications

La enfermedad por reflujo gastroesofágico (ERGE) es una condición compleja y altamente prevalente. El deterioro de la comunicación intestino-cerebro está asociado a la disfunción autonómica. La modulación del sistema nervioso autónomo controla las funciones gastrointestinales. En la ERGE se han reportado una disminución del tono vagal (actividad parasimpática) y un aumento de la actividad simpática, con el equilibrio autónomo desplazado hacia el sistema simpático. Los cuestionarios clínicos y la medición de la variabilidad de la frecuencia cardiaca, método no invasor, pueden ser útiles en los pacientes con ERGE para detectar la disfunción autonómica. La restauración de la actividad del sistema …

Testing The Antigenic Potential Of Transmembrane Proteins To Develop A Thermostable Tuberculosis Mof-Liposomal Vaccine, Sneha Kumari, Jonathan Martinez-Garcia, Ryanne Nicole Ehrman, Wendy Tang, Joshua Miles, Priyanka Basak, Thomas Sinclair Howlett, Yalini Hansika Wijesundara, Ziqi Wang, Blanca I. Restrepo

School of Medicine Publications

Tuberculosis is one of the deadliest infectious diseases and continues to be a major health risk in many parts of the world. Even today, the century-old Bacillus Calmette-Guerin (BCG) vaccine is the only formulation on the market and is ineffective for several sections of the global population responsible for transmission. In the search for antigens that can mount a robust immune response, we have reported the recombinant expression and purification of two novel membrane proteins, the Cation transporter protein V (CtpV) and the Mycobacterial copper transporter B (MctB) present on the membrane surface of Mycobacterium tuberculosis. CtpV was tested …

Infants’ Resting-State Functional Connectivity And Event-Related Potentials: A Multimodal Approach To Investigating The Neural Basis Of Infant Novelty Detection, Dana Kanel, Santiago Morales, Kathryn Altman, John E. Richards, Anderson M. Winkler, Daniel Samuel Pine, Nathan A. Fox, Courtney A. Filippi

School of Medicine Publications

Individual differences in how the brain responds to novelty are present from infancy. A common method of studying novelty processing is through event-related potentials (ERPs). While ERPs possess millisecond precision, spatial resolution remains poor, especially in infancy. This study aimed to balance spatial and temporal precision by combining ERP data with functional magnetic resonance imaging (fMRI) data. Twenty-nine infants (15 female) underwent resting-state fMRI (Mage = 4.73 months) and electroencephalography (EEG) during a three-stimulus auditory oddball task (Mage = 5.19 months). The mismatch response (MMR) and P3 were computed from ERP data, and resting-state functional connectivity …

Clinical Criteria For Limbic-Predominant Age-Related Tdp-43 Encephalopathy, David A. Wolk, Peter T. Nelson, Liana Apostolova, Konstantinos Arfanakis, Patricia A. Boyle, Cynthia M. Carlsson, Nick Corriveau-Lecavalier, Penny Dacks, Bradford C. Dickerson, Gladys E. Maestre

School of Medicine Publications

Limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is highly prevalent in late life and a common co-pathology with Alzheimer's disease neuropathologic change (ADNC). LATE-NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course. With the emergence of anti-amyloid therapeutics, discrimination of LATE-NC from ADNC is critical and will lead to greater clinical recognition of amnestic patients without ADNC. Furthermore, co-pathology with LATE-NC may influence outcomes of these therapeutics. Thus there is a need to identify patients during life with likely LATE-NC. We propose criteria for clinical diagnosis of …