Medicine and Health Sciences Commons^™

Follow Up Care For Heart Failure Patients And Association With Hospital Readmission, Supraja Thunuguntla, Michael Machiorlatti, Sonya Rivera, Juan Cortinas Galvan, Jose Campo Maldonado

School of Medicine Publications

Background:

The CDC reports 6.5 million adults in the US have Heart failure (HF) with yearly costs topping 30 billion. HF patients admitted to Valley Baptist (VB) are readmitted 26% of the time, which is close to the national average of 23% [1]. Standard of care for HF patients is remote nursing care for 30 days from discharge. A hospitalization for any reason within 30 days is considered a “readmission”. On October 1, 2019 at VB remote nursing care changed from weekly house visits to weekly phone calls. The aim of the study is to evaluate the effectiveness of this …

The Genetic Architecture Of The Human Cerebral Cortex, Katrina L. Grasby, Neda Jahanshad, Jodie N. Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P. Hibar, Penelope A. Lind, Fabrizio Pizzagalli, Marcio A. Almeida, Joanne E. Curran, John Blangero

School of Medicine Publications

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area …

Enigma And Global Neuroscience: A Decade Of Large-Scale Studies Of The Brain In Health And Disease Across More Than 40 Countries, Paul M. Thompson, Neda Jahanshad, Christopher R. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Anderson M. Winkler

School of Medicine Publications

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development …

Never Count Out A Melanoma: A Case Report Detailing A Small Bowel Mass, Baine Herrera, Fernando C. Diaz, Dayan Ojeda Damas, Henry Kwang

School of Medicine Publications

No abstract provided.

Pectin-Tannic Acid Nano-Complexes Promote The Delivery And Bioactivity Of Drugs In Pancreatic Cancer Cells, Sumeet S. Chauhan, Advait B. Shetty, Elham Hatami, Pallabita Chowdhury, Murali M. Yallapu

School of Medicine Publications

Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa offer severe systemic toxicities. Thus, the development of a successful nanomedicine-based therapeutic regimen with augmented therapeutic efficacy is highly sought. Naturally occurring pectin and modified pectin-based drug delivery systems exhibit remarkable self-targeting ability via galactose residues to various cancer cells. Herein, we developed and used an innovative approach of highly stable nanocomplexes based on modified pectin and tannic acid (MPT-NCs). The nanocomplex formation was enabled by strong intermolecular interactions between pectin and tannic acid under very mild conditions. These nanocomplexes were characterized by particle size and morphology (DLS, TEM, …

The Infectious Headache- A Case Of Neurocysticercosis, Supraja Thunuguntla, Obinna Echeruo, Jose Campo Maldonado

School of Medicine Publications

A 50-year-old Hispanic female presented to her primary care physician with a progressively worsening headache over a week, associated with visual disturbances, prosopagnosia and episodes of disorientation. Outpatient workup with head CT showed abnormality in the ventral aspect of the left thalamus showing 1.2 × 1 cm low density cyst with approximately 2-3 mm right-left midline shift locally. Left basal ganglia showed multiple well-defined foci of low density measuring up to 3 mm reflecting edema. On admission, pertinent physical exam findings were left sided nystagmus, positive deep tendon reflexes (DTRs) in the right lower extremity (RLE), positive Babinski on the …

Meeting The Educational Needs Of An Increasingly Diverse Surgical Workforce, Minerva Angelica Romero Arenas

School of Medicine Publications

To the Editor Yeo et al¹ evaluated factors associated with American Board of Surgery (ABS) examination pass rates in a cohort of categorical surgical residents from the internship (2007) to eligibility/certification. They found that first-time ABS pass rate was associated with nonmodifiable factors, such as nonwhite race/ethnicity, sex (women), and having children.¹ Additionally, Hispanic residents were less likely to attempt the ABS examinations at all. We must place these findings in the context of diversity in surgery, or rather, the lack thereof. The cohort included only 55 Hispanic residents, most of whom did pass the ABS examinations (n …

Over-The-Counter Availability Of Levonorgestrel Emergency Contraception In Pharmacies On Oahu, Jennifer Chin, Jennifer Salcedo, Shandhini Raidoo

School of Medicine Publications

Since the United States Food and Drug Administration’s approval of over-the-counter levonorgestrel emergency contraception, access to this time-sensitive medication has improved. However, multiple barriers, including the cost of the medication and pharmacy availability, still exist. The objective of this study was to determine the over-the-counter availability of levonorgestrel emergency contraception in pharmacies on Oahu, Hawaii. We conducted a cross-sectional population-based study using in-person simulated patient encounters at all pharmacies on Oahu. Out of 109 chain pharmacies and 13 independent pharmacies, 102 (84%) pharmacies had levonorgestrel emergency contraception available over the counter. Of pharmacies in which it was available, 12.7% required …

Cognitive Impairment From Early To Middle Adulthood In Patients With Affective And Nonaffective Psychotic Disorders, Josephine Mollon, Samuel R. Mathias, Emma Knowles, Amanda Rodrigue, Marinka M. G. Koenis, Godfrey D. Pearlson, Abraham Reichenberg, Jennifer Barrett, Dominique Denbow, Katrina Aberizk, Molly Zatony, Russell A. Poldrack, John Blangero, David C. Glahn

School of Medicine Publications

Background.—Cognitive impairment is a core feature of psychotic disorders, but the profile of impairment across adulthood, particularly in African-American populations, remains unclear.

Methods.—Using cross-sectional data from a case–control study of African-American adults with affective (n = 59) and nonaffective (n = 68) psychotic disorders, we examined cognitive functioning between early and middle adulthood (ages 20–60) on measures of general cognitive ability, language, abstract reasoning, processing speed, executive function, verbal memory, and working memory.

Results.—Both affective and nonaffective psychosis patients showed substantial and widespread cognitive impairments. However, comparison of cognitive functioning between controls and psychosis groups throughout early …

Novel Elvitegravir Nanoformulation For Drug Delivery Across The Blood-Brain Barrier To Achieve Hiv-1 Suppression In The Cns Macrophages, Yuqing Gong, Pallabita Chowdhury, Prashanth K.B. Nagesh, Mohammad A. Rahman, Kaining Zhi, Murali M. Yallapu, Santosh Kumar

School of Medicine Publications

The use of antiretroviral therapy (ART) has remarkably decreased the morbidity associated with HIV-1 infection, however, the prevalence of HIV-1-associated neurocognitive disorders (HAND) is still increasing. The blood-brain barrier (BBB) is the major impediment for penetration of antiretroviral drugs, causing therapeutics to reach only suboptimal level to the brain. Conventional antiretroviral drug regimens are not sufficient to improve the treatment outcomes of HAND. In our recent report, we have developed a poloxamer-PLGA nanoformulation loaded with elvitegravir (EVG), a commonly used antiretroviral drug. The nanoformulated EVG is capable of elevating intracellular drug uptake and simultaneously enhance viral suppression in HIV-1-infected macrophages. …

Clinical Features And Outcomes Of Takotsubo (Stress) Cardiomyopathy In South Texas Hispanics, Cesar H. Gutierrez, Wady Aude

School of Medicine Publications

Background

Takotsubo cardiomyopathy (TSC) can be preceded by emotional, physical, or no identifiable trigger. Despite being a transient condition, it is associated with a substantial risk for in-hospital adverse events. The clinical features and the short-term outcomes of TSC in South Texas Hispanics (STH) are unknown.

Methods

We identified patients with the diagnosis of TSC at an academic institution from 2005-2017. Patients who did not have coronary angiography were excluded. Demographics, presenting symptoms, triggers, left ventricular characteristics and outcomes were expressed as percentages. Continuous variables were expressed as means.

Results

Of 41 patients with TSC, the diagnosis was confirmed in …

Imaging Local Genetic Influences On Cortical Folding, Aaron F. Alexander-Bloch, Armin Raznahan, Simon N. Vandeker, Jakob Seidlitz, Zhixin Lu, Samuel R. Matthias, Emma Knowles, Josephine Mollon, Amanda Rodrigue, Joanne E. Curran, Harald H. H. Goring, Peter T. Fox, John Blangero

School of Medicine Publications

Recent progress in deciphering mechanisms of human brain cortical folding leave unexplained whether spatially patterned genetic influences contribute to this folding. High-resolution in vivo brain MRI can be used to estimate genetic correlations (covariability due to shared genetic factors) in interregional cortical thickness, and biomechanical studies predict an influence of cortical thickness on folding patterns. However, progress has been hampered because shared genetic influences related to folding patterns likely operate at a scale that is much more local (cm) than that addressed in prior imaging studies. Here, we develop methodological approaches to examine local genetic influences on cortical thickness and …

Dose Response Of The 16p11.2 Distal Copy Number Variant On Intracranial Volume And Basal Ganglia, Ida E. Sønderby, Ómar Gústafsson, Nhat Trung Doan, Nicholas B. Blackburn, John Blangero, Joanne E. Curran, Juan M. Peralta

School of Medicine Publications

Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = −0.71 to −1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = −0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P=0.0032, 8.9 × 10−6, 1.7 × 10−9, 3.5 × 10−12 and 1.0 × 10−4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to noncarriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.

Consortium Of Otolaryngology Journal Editors: Collegiality And Contributions, Robert T. Sataloff, Rakesh Chandra, Edward W. Fisher, David Goldenberg, Ehab Y. Hanna, Jonas Johnson, David W. Kennedy, Dennis H. Kraus, John H. Krouse, Michael Link

School of Medicine Publications

There is a new tradition in the otolaryngology publishing community that is unique to our specialty, so far as we know. Editors-in-Chief of otolaryngology journals in the United States, and intermittently some of our international colleagues such as the Editor of the Journal of Laryngology and Otology (England), sit down together twice a year to discuss topics of mutual interest, maintain lines of communication and friendships, and share perspectives on the evolution of otolaryngology—head and neck surgery and needs that our journals might help address. To establish these collegial, uninhibited, informative, and productive meetings, Dr Robert Ruben proposed the idea …

Extracellular Vesicles From Human Papilloma Virus-Infected Cervical Cancer Cells Enhance Hiv-1 Replication In Differentiated U1 Cell Line, Sabina Ranjit, Sunitha Kodidela, Namita Sinha, Subhash C. Chauhan, Santosh Kumar

School of Medicine Publications

In the current study, we hypothesized that extracellular vesicles (EVs) secreted from human papilloma virus (HPV)-infected cervical cancer cells exacerbate human immunodeficiency virus (HIV)-1 replication in differentiated U1 cell line through an oxidative stress pathway. To test the hypothesis, we treated an HIV-1-infected macrophage cell line (U1) with HPV-infected Caski cell culture supernatant (CCS). We observed a significant increase in HIV-1 replication, which was associated with an increase in the expression of cytochrome P450 (CYPs 1A1 and 2A6) in the CCS-treated U1 cells. Furthermore, we isolated EVs from CCS (CCS-EVs), which showed the presence of CYPs (1A1, 2A6), superoxide dismutase …

Steps-T Program Improves Endovascular Treatment Outcomes Of Acute Ischemic Stroke; A 6-Year Study, Ameer E. Hassan, Rani R. Rabah, Laurie Preston, Wondwossen G. Tekle

School of Medicine Publications

Background: Early endovascular recanalization of occluded vessels in acute ischemic stroke (AIS) is a major contributor to good clinical outcome. We report the analysis of all AIS patients throughout a 6-year experience following the deployment of a quality initiative aiming at improving care, speed and maintaining quality for AIS treatment.

Methods: Using a prospectively collected endovascular database at a comprehensive stroke center between 2012 and 2017, workflow/outcomes were recorded. There were no exclusion criteria. During the first year, a quality program employing “digital-object” technology, staff education, and workflow improvement was implemented to reduce time-to-treatment. Using electronic recording, workflow times were …

Development Of Learning Objectives To Guide Enhancement Of Chronic Disease Prevention And Management Curricula In Undergraduate Medical Education, Michael Dekhtyar, Cristin Colford, Ebony Whisenant, Jill Huber, Eric Johnson, Patricia Thomas, Kate Kirley, Lauren Mazzurco, Arden D. Dingle, Valerie Terry, Senthil Rajasekaran, Laken Barkowski, Mrinalini Kulkarni-Date, David Henderson, Luann Wilkerson

School of Medicine Publications

Phenomenon: Chronic disease is a leading cause of death and disability in the United States. With an increase in the demand for healthcare and rising costs related to chronic care, physicians need to be better trained to address chronic disease at various stages of illness in a collaborative and cost-effective manner. Specific and measurable learning objectives are key to the design and evaluation of effective training, but there has been no consensus on chronic disease learning objectives appropriate to medical student education. Approach: Wagner’sChronic Care Model (CCM) was selected as a theoretical framework to guide development of an enhanced chronic …

Histological Variation Of Early Stage Atherosclerotic Lesions In Baboons After Prolonged Challenge With High-Cholesterol, Highfat Diet, Genesio M. Karere, Edward J. Dick Jr, Samuel Galindo Jr., Jesse C. Martinez, Jacob E. Martinez, Michael Owston, John L. Vandeberg, Laura Cox

School of Medicine Publications

Introduction—The baboon is a well-characterized model of human early stage atherosclerosis. However, histological and morphological changes involved in atherogenesis in baboons are not known. Previously we challenged baboons with a high-cholesterol, high-fat diet for two years and observed fatty streak and plaque lesions in iliac arteries (RCIA). Methods—We evaluated histological and morphological changes of baboon arterial lesions and control arteries. In addition, we evaluated the vascular expression of CD68 and SMαA markers with progression of atherosclerosis. Results—We observed changes that correlated with extent of atherosclerosis, including increased maximum intimal thickness. We demonstrated at molecular level the infiltration of smooth muscle …

Identifying Risks Of Readmission In Patients With Dementia In Snf For Targeted Community-Based Palliative Consultation (Qi644), Irma Duncan, Maria Cantu-Cooper

School of Medicine Publications

Objectives

• Describe the HOSPITAL score and apply it to patients with dementia discharged to skilled nursing facility (SNF).
• Compare risk factors including HOSPITAL score, Charlson Comorbidity Index, and high-risk discharge medications for risk of 60-day readmission from skilled nursing facility for patients with dementia.
• Identify patients with dementia at SNF who are at-risk for multiple transitions of care who may benefit from SNF-based palliative care consultation.

Background

Dementia patients are at high risk for preventable hospital readmission. This population could benefit from expert consultation in SNF to reduce readmission rates. Community-based palliative medicine focusing on symptom management and goals of …

Heritability Of 596 Lipid Species And Genetic Correlation With Cardiovascular Traits In The Busselton Family Heart Study, Gemma Cadby, Phillip E. Melton, Nina S. Mccarthy, Corey Giles, Natalie A. Mellett, Kevin Huynh, Joseph Hung, John Beilby, Marie-Pierre Dube, Gerald F. Watts, John Blangero, Peter J. Meikle, Eric K. Moses

School of Medicine Publications

Introduction: Cardiovascular disease (CVD) is the leading cause of death worldwide, and genetic investigations into the human lipidome may provide insight into CVD risk. The aim of this study was to estimate the heritability of circulating lipid species and their genetic correlation with CVD traits.

Methods: Targeted lipidomic profiling was performed on 4492 participants from the Busselton Family Heart Study to quantify the major fatty acids of 596 lipid species from 33 classes. We estimated narrow-sense heritabilities of lipid species/classes, and their genetic correlations with eight CVD traits – body mass index, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglycerides, …

Dysphagia Screening For Pneumonia Prevention In A Cancer Hospital: Results Of A Quality/Safety Initiative., Barbara Ebersole, Miriam Lango, John Ridge, Elizabeth Handorf, Jeffrey Farma, Sarah Clark, Nausheen Jamal

School of Medicine Publications

Objective

Hospital-acquired aspiration pneumonia remains a rare but potentially devastating problem. The best means by which to prevent aspiration in a cancer hospital population has not been evaluated. The aim of this study was to evaluate the impact of dysphagia screening on aspiration pneumonia rates in an acute care oncology hospital.

Methods

A prospective single-institution quality-improvement dysphagia screening protocol at a comprehensive cancer center. Effect of dysphagia screening implemented in 2016 on hospital acquired aspiration pneumonia rates coded “aspiration pneumonitis due to food/vomitus” were compared with rates from 2014-15, prior to implementation. Screening compliance, screening outcomes, patient demographics, and medical …

A Transcriptome-Wide Association Study Based On 27 Tissues Identifies 106 Genes Potentially Relevant For Disease Pathology In Age-Related Macular Degeneration, Tobias Strunz, Susette Lauwen, Christina Kiel, Lars G. Fritsche, Wilmar Igl, Jessica N.Cooke Bailey, Felix Grassmann, Sebanti Sengupta, Jennifer L. Bragg-Gresham, Matthew P. Johnson, John Blangero

School of Medicine Publications

Genome-wide association studies (GWAS) for late stage age-related macular degeneration (AMD) have identified 52 independent genetic variants with genome-wide significance at 34 genomic loci. Typically, such an approach rarely results in the identification of functional variants implicating a defined gene in the disease process. We now performed a transcriptome-wide association study (TWAS) allowing the prediction of effects of AMD-associated genetic variants on gene expression. The TWAS was based on the genotypes of 16,144 late-stage AMD cases and 17,832 healthy controls, and gene expression was imputed for 27 different human tissues which were obtained from 134 to 421 individuals. A linear …

Combining Fmri During Resting State And An Attention Bias Task In Children, Anita Harrewijn, Rany Abend, Julia Linke, Melissa A. Brotman, Nathan A. Fox, Ellen Leibenluft, Anderson M. Winkler, Daniel Samuel Pine

School of Medicine Publications

Neuroimaging studies typically focus on either resting state or task-based fMRI data. Prior research has shown that similarity in functional connectivity between rest and cognitive tasks, interpreted as reconfiguration efficiency, is related to task performance and IQ. Here, we extend this approach from adults to children, and from cognitive tasks to a threat-based attention task. The goal of the current study was to examine whether similarity in functional connectivity during rest and an attention bias task relates to threat bias, IQ, anxiety symptoms, and social reticence. fMRI was measured during resting state and during the dot-probe task in 41 children …

Relief And Recovery Activities Conducted By The Better Research, Better Life Foundation (Brblf) In Collaboration With The Caribbean Primate Research Center (Cprc), John L. Vandeberg, B. Predovich, M. I. Rodriguez, C. A. Sariol, M. Khan

School of Medicine Publications

BRBLF, a 501(c)(3) non‐profit organization, is dedicated to the advancement of global preclinical research while focusing on the responsible use of nonhuman primates. Its goal is to optimize the contribution of nonhuman primates to biomedical and behavioral research by fostering innovative collaborations, education, training, and outreach. Immediately after Hurricane Maria, BRBLF and CPRC leadership initiated an emergency plan and began to develop and implement disaster relief and research continuity solutions for Cayo Santiago and the Sabana Seca Field Station. The initial action was to provide satellite phones, which enabled CPRC staff to re‐establish stable communication with the mainland and to …

Pluronic Polymer-Based Ormeloxifene Nanoformulations Induce Superior Anticancer Effects In Pancreatic Cancer Cells, Neeraj Chauhan, Amber Kruse, Hilary Newby, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

Utilization of safe cytotoxic agents with precise anticancer activity is considered as the prime focus of cancer therapeutics research. A greater incentive for such agents arises from the molecules/drugs that are already being used for other indications. Ormeloxifene (ORM) is a nonsteroidal, nonhormonal selective estrogen receptor modulator (SERM), which has been in human use for contraception purposes. Although in the recent past, many reports have suggested its emerging role as an anticancer agent, no significant attention was paid toward generating simple and safe nanoformulation( s) for improved therapeutic activity and tumor cell-specific delivery. Our aim is to develop nanoformulation(s) of …

Highly Efficient Induced Pluripotent Stem Cell Reprogramming Of Cryopreserved Lymphoblastoid Cell Lines, Satish Kumar, Joanne E. Curran, Erika C. Espinoza, David C. Glahn, John Blangero

School of Medicine Publications

Tissue culture based in-vitro experimental modeling of human inherited disorders provides insight into the cellular and molecular mechanisms involved and the underlying genetic component influencing the disease phenotype. The breakthrough development of induced pluripotent stem cell (iPSC) technology represents a quantum leap in experimental modeling of human diseases, providing investigators with a self-renewing and thus unlimited source of pluripotent cells for targeted differentiation into functionally relevant disease specific tissue/cell types. The existing rich bio-resource of Epstein-Barr virus (EBV) immortalized lymphoblastoid cell line (LCL) repositories generated from a wide array of patients in genetic and epidemiological studies worldwide, many of them …

Biophysical Changes Caused By Altered Muc13 Expression In Pancreatic Cancer Cells, Andrew E. Massey, Kyle Doxtater, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

Background

Pancreatic cancer is one of the most lethal cancers in the United States. This is partly due to the difficulty in early detection of this disease as well as poor therapeutic responses to currently available regimens. Our previous reports suggest that mucin 13 (MUC13, a transmembrane mucin common to gastrointestinal cells) is aberrantly expressed in this disease state, and has been implicated with a worsened prognosis and an enhanced metastatic potential in PanCa. However, there is virtually no information currently to describe the biophysical ramifications of this protein.

Methods

To demonstrate the biophysical effect of MUC13 in PanCa, we …

Detecting Invasive Fungal Disease In Surgical Patients: Utility Of The (1 3)- B-D-Glucan Assay, Jeffrey Skubic, Sharven Taghavi, Manuel Castillo-Angeles, Ramsis Ramsis, Ali Salim, Reza Askari

School of Medicine Publications

Background: The specificity and sensitivity of the (1 3)-b-d-glucan (BDG) assay in surgical patients needs further investigation. We hypothesized that the BDG assay would have lower sensitivity/specificity compared with that of medical patients.

Methods: We reviewed patients who had undergone laparotomy, gastrectomy, hepatectomy, or colectomy and had a BDG assay post-operatively.

Results: A total of 71 patients met study criteria. There were 29 (40.8%) who had proven/probable invasive fungal infection. Sensitivity for BDG level ‡80 diagnosed within one week of the assay draw was 77.3% (95% confidence interval [CI], 54.6–92.2%), and specificity was 44.9% (95% CI, 30.7–59.8). The positive predictive …

Cardiometabolic Risk Factors Associated With Renal Function In Apparently Healthy Young Students: A Cross-Sectional Study, Lucia M. Perez-Navarro, Rafael Valdez-Ortiz, Araceli Alegria-Diaz, Miguel Murgia-Romero, Rafael Jimenez-Flores, Rafael Villalobos-Molina, Srinivas Mummidi, Ravindranath Duggirala, Juan Carlos Lopez Alvarenga

School of Medicine Publications

Background: Cardiometabolic risk factors (CMRFs) appear decades before developing chronic kidney disease (CKD) in adulthood.

Objective: The objective of the study was to identify the prevalence and association between CMRFs and kidney function in apparently healthy young adults (18-25 years old).

Methods: We included 5531 freshman year students. Data collected on CMRFs included central obesity, high body mass index (hBMI >25), blood pressure, glycemia, lipids, uric acid (UA >6.8 mg/dL), and insulin. Glomerular filtration rate (GFR) was estimated by CKD-Epidemiology Collaboration formula. We used logistic regression and a log linear for odds ratio (OR) (95% confidence level) and probabilities.

Results: …

Cardiometabolical Risk Factors Associated With Renal Function In Apparently Healthy Young Students: A Cross-Sectional Study, Lucia M. Perez-Navarro, Rafael Valdez-Ortiz, Araceli Alegria-Diaz, Miguel Murgia-Romero, Rafael Jimenez-Flores, Rafael Villalobos-Molina, Srinivas Mummidi, Ravindranath Duggirala, Juan C. Lopez-Alvarenga

School of Medicine Publications

Background: Cardiometabolic risk factors (CMRFs) appear decades before developing chronic kidney disease (CKD) in adulthood.

Objective: The objective of the study was to identify the prevalence and association between CMRFs and kidney function in apparently healthy young adults (18-25 years old).

Methods: We included 5531 freshman year students. Data collected on CMRFs included central obesity, high body mass index (hBMI >25), blood pressure, glycemia, lipids, uric acid (UA >6.8 mg/dL), and insulin. Glomerular filtration rate (GFR) was estimated by CKD-Epidemiology Collaboration formula. We used logistic regression and a log linear for odds ratio (OR) (95% confidence level) and probabilities.

Results: …