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Update: West Nile-Like Viral Encephalitis — New York, 1999, Centers For Disease Control And Prevention, Denis Nash

Publications and Research

The outbreak of human arboviral encephalitis attributable to a mosquito-transmitted West Nile-like virus (WNLV) continues to wane in the Northeast (Figure 1). As of October 5, the number of laboratory-positive cases had increased to 50 (27 confirmed and 23 probable), including five deaths. The increase in cases is mainly a result of completed retesting with West Nile virus antigen of specimens previously tested with the related St. Louis encephalitis virus antigen and to intensive retrospective case finding in the ongoing epidemiologic investigations (1,2).

Outbreak Of West Nile-Like Viral Encephalitis -- New York, 1999, Centers For Disease Control And Prevention, Denis Nash

Publications and Research

An outbreak of arboviral encephalitis was first recognized in New York City in late August and has since been identified in neighboring counties in New York state. Although initially attributed to St. Louis encephalitis (SLE) virus based on positive serologic findings in cerebrospinal fluid (CSF) and serum samples using a virus-specific IgM-capture enzyme-linked immunosorbent assay (ELISA), the cause of the outbreak has been confirmed as a West Nile-like virus based on the identification of virus in human, avian, and mosquito.

Quality Of Care In Investor-Owned Vs Not-For-Profit Hmos, David U. Himmelstein, Steffie Woolhandler, Ida Hellander, Sidney M. Wolfe

Publications and Research

Context The proportion of health maintenance organization (HMO) members enrolled in investor-owned plans has increased sharply, yet little is known about the quality of these plans compared with not-for-profit HMOs.

Objective To compare quality-of-care measures for investor-owned and not-for-profit HMOs.

Design, Setting, and Participants Analysis of the Health Plan Employer Data and Information Set (HEDIS) Version 3.0 from the National Committee for Quality Assurance's Quality Compass 1997, which included 1996 quality-of-care data for 329 HMO plans (248 investor-owned and 81 not-for-profit), representing 56% of the total HMO enrollment in the United States.

Main Outcome Measures Rates for 14 HEDIS quality-of-care …

The Guillain-Barre Syndrome And The 1992-1993 And 1993-1994 Influenza Vaccines, Tamar Lasky, Gina J. Terracciano, Laurence Magder, Carol Lee Koski, Michael Ballesteros, Denis Nash, Shelley Clarke, Penina Haber, Paul D. Stolley, Lawrence B. Schonberger, Robert T. Chen

Publications and Research

Background
The number of reports of influenza-vaccine-associated Guillain-Barré syndrome to the national Vaccine Adverse Event Reporting System increased from 37 in 1992-1993 to 74 in 1993-1994, arousing concern about a possible increase in vaccine-associated risk.

Methods
Patients given a diagnosis of the Guillain-Barré syndrome in the 1992-1993 and 1993-1994 influenza-vaccination seasons were identified in the hospital-discharge data bases of four states. Vaccination histories were obtained by telephone interviews during 1995-1996 and were confirmed by the vaccine providers. Disease with an onset within six weeks after vaccination was defined as vaccine-associated. Vaccine coverage in the population was measured through a random-digit-dialing …

Mechanism Of Triazolo-Benzodiazepine And Benzodiazepine Action In Anxiety And Depression: Behavioral Studies With Concomitant In Vivo Ca1 Hippocampal Norepinephrine And Serotonin Release Detection In The Behaving Animal, Patricia A. Broderick, Omotola Hope, Pierrot Jeannot

Publications and Research

1. Real time, in vivo microvoltammetric studies were performed, using miniature carbon-based sensors, to concurrently detect norepinephrine (NE) release and serotonin (5-HT) release, in 2 separate electrochemical signals, within CA₁ region of hippocampus in the freely moving and behaving, male, Sprague Dawley laboratory rat.

2. Concurrently, four parameters of open-field Behavior I.E. Ambulations, Rearing, Fine Movements and Central Ambulatory behavior (a measure of anxiety reduction behavior), were assayed by infrared photobeam detection.

3. Time course studies showed that the mechanism of action of the triazolobenzodiazepine (TBZD), adinazolam, (Deracyn®) is dramatically different from that of the classical benzodiazepine (BZD), diazepam …

Myelin-Associated Glycoprotein Interacts With Neurons Via A Sialic Acid Binding Site At Arg118 And A Distinct Neurite Inhibition Site, Song Tang, Ying Jing Shen, Maria Elena Debellard, Gitali Mukhopadhyay, James L. Salzer, Paul R. Crocker, Marie T. Filbin

Publications and Research

Inhibitory components in myelin are largely responsible for the lack of regeneration in the mammalian CNS. Myelin-associated glycoprotein (MAG), a sialic acid binding protein and a component of myelin, is a potent inhibitor of neurite outgrowth from a variety of neurons both in vitro and in vivo. Here, we show that MAG’s sialic acid binding site is distinct from its neurite inhibitory activity. Alone, sialic acid–dependent binding of MAG to neurons is insufficient to effect inhibition of axonal growth. Thus, while soluble MAG-Fc (MAG extracellular domain fused to Fc), a truncated form of MAG-Fc missing Ig-domains 4 and 5, MAG(d1-3)-Fc, …

Transcranial Magnetic Stimulation Of The Prefrontal Cortex Delays Contralateral Endogenous Saccades, Tony Ro, Avishai Henik, Liana Machado, Robert D. Rafal

Publications and Research

The contributions of the superior prefrontal cortex (SPFC) and the superior parietal lobule (SPL) in generating voluntary endogenous and reflexive visually guided saccades were investigated using transcranial magnetic stimulation (TMS). Subjects made choice saccades to the left or right visual field in response to a central arrowhead (endogenous go signal) or a peripheral asterisk (exogenous go signal) that were presented along with a single TMS pulse at varying temporal intervals. TMS over the SPFC increased latencies for saccades made in response to an endogenous go signal toward the contralateral hemifield. No effects were observed when the go signal was exogenous …

Effects Of A Sugar-Free Hypoallerdenic Diet And Nutrtional Supplementation On Ulcerative Colitis, William (Bill) H. Williams, Robert C. Atkins Md, Joel S. Edman

Publications and Research

Few clinical studies have found that dietary or nutritional factors significantly influence ulcerative colitis (UC}(l,2}. It is noteworthy, however, that a range of factors have been researched including dietary components such as refined sugars (3,4}, allergenic foods (1,5,6} and fast foods (7), as well as nutritional supplement effects from fish oil (2), zinc (8), glutamine (9), folate (10, 11} and alpha-tocopherolquinone (12}. More recently investigators have also examined the interelationships between bowel flora and UC, including factors such as flora changes (13,14), endotoxemia (15} and supplementation effects with Lactobacillous species (16,17). These studies taken together and a recent review of …

Psychiatric Outcomes In Low Birthweight Children At Age Six: Relation To Neonatal Cranial Ultrasound Abnormalities, Agnes H. Whitaker, Ronan Van Rossem, Judy F. Feldman, Irvin Sam Schonfeld, Jennifer A. Pinto-Martin, Carolyn Torre, David Shaffer, Nigel Paneth

Publications and Research

Examined the relation of neonatal cranial ultrasonography abnormalities to later psychiatric disorder in 564 low birth weight children (aged 5.2–8.7 yrs). Psychiatric diagnoses were assessed by means of the Diagnostic Interview Schedule for Children–Parent version, and detailed information was collected on other predictors and outcomes. Results show that 454 Ss had no cranial abnormalities, 78 had germinal matrix hemorrhage (GMH) and/or intraventricular hemorrhage (IVH), and 32 had a parenchymal lesion (PL) or ventricular enlargement (VE). 22% of the Ss had at least 1 psychiatric disorder, the most common being attention deficit hyperactivity disorder (ADHD). Isolated GMH/IVH did not increase …

Minor Physical Anomalies: Modifiers Of Environmental Risk For Psychopathology, Daniel S. Pine, David Shaffer, Irvin Sam Schonfeld, Mark Davies

Publications and Research

Tested the hypothesis that minor physical anomalies (MPAs) modify an adolescent's vulnerability to environmental risk factors for psychopathology. 118 male 17-yr-olds who had been evaluated as 7-year-olds received a comprehensive neuropsychiatric evaluation. The evaluation included standardized assessments of environmental risk factors for psychiatric impairment, neurological signs, IQ, MPAs, and psychiatric impairment. The relationship between psychiatric status and environmental risk was examined as a function of the MPA profile. There was a significant interaction between MPAs and environmental risk in predicting psychiatric status. Environmental risk was more predictive of psychiatric impairment at age 17 in Ss with high scores on the …

Neonatal Cranial Ultrasound Abnormalities In Lbw Infants: Relation To Cognitive Outcomes At Age Six, Agnes H. Whitaker, Judy F. Feldman, Ronan Van Rossem, Irvin Sam Schonfeld, Jennifer A. Pinto-Martin, Carolyn Torre, Suzannah R. Blumenthal, Nigel S. Paneth

Publications and Research

bjective: To assess the independent relation of neonatal cranial ultrasound (US) abnormalities in low birth weight (LBW) infants to cognitive outcomes at 6 years of age.
Design: Prospective cohort study.
Sample and Methods: Six-year follow-up data were obtained on a regional birth cohort of LBW infants (< 2 kg) systematically screened as neonates with serial US. US abnormalities were dichotomized into isolated germinal matrix/intraventricular hemorrhage (GM/IVH) and parenchymal lesions/ventricular enlargement (PL/VE). Global cognitive outcomes (mental retardation, borderline intelligence, and normal intelligence) and selected specific cognitive abilities were assessed at 6 years of age with standardized instruments. Multivariate techniques were used to assess the effects of US independent of maternal social …

Relation Of Negative Affectivity To Self-Reports Of Job Stressors And Psychological Outcomes, Irvin Sam Schonfeld

Publications and Research

A total of 250 new women teachers participated in a longitudinal study of the influence of negative affectivity (NA) on the relation of self-report work-environment measures to psychological outcomes. Three "neutrally worded" work-environment measures were specially constructed to minimize confounding with NA. The work-environment measures were moderately related to postemployment depressive symptoms, job satisfaction, and, among Whites but not among a principally Black and Hispanic subsample, motivation. Correlation and regression coefficients were largely unchanged when the preemployment psychophysiologic symptoms scale and the Center for Epidemiologic Studies-Depression Scale (L. S. Radloff, 1977), factors that tap NA, were controlled. Findings suggest NA …

A Population-Based Serologic Survey Of Immunity To Tetanus In The United States, Peter J. Gergen, Geraldine M. Mcquillan, Michele Kiely, Trena M. Ezzati-Rice, Roland W. Sutter, Gabriel Virella

Publications and Research

Background. Vaccination rates are frequently considered a surrogate measure of protection. To provide more accurate estimates, serum levels of antibody against tetanus were measured as part of the third National Health and Nutrition Examination Survey (NHANES III), which studied a representative sample of the civilian, noninstitutionalized population of the United States.

Methods. We measured tetanus antitoxin using a solid- phase enzyme immunoassay in serum samples from 10,618 persons six years of age and older who were examined during phase 1 of NHANES III in 1988 to 1991.

Results. Overall, 69.7 percent of Americans six years of age and …

Methodological Issues In Occupational-Stress Research: Research In One Occupational Group And Its Wider Applications, Irvin Sam Schonfeld, Jaesoon Rhee, Fang Xia

Publications and Research

The chapter addresses a number of important methodologic issues that are relevant to occupational-stress researchers. The issues addressed have arisen in the context of an ongoing research program involving cross-sectional and longitudinal studies of stress in teachers; the issues, however, apply to occupational research in general. The first issue involves measurement strategies required in operationalizing the stress process. The focal concern is the reduction of confounding in measures of the work environment. The second issue encompasses the question of whether to sample new or veteran workers. The third issue applies to types of job stressors. The chapter describes a …

A Longitudinal Study Of Occupational Stressors And Depressive Symptoms In First-Year Teachers, Irvin Sam Schonfeld

Publications and Research

Administered the Center for Epidemiologic Studies Depression Scale and episodic stressor and strain scales to 255 female newly appointed teachers. Job conditions were related to postemployment depressive symptoms independently of pre-employment symptoms and other risk factors. Ss who worked in the most adverse school environments showed the most depressive symptoms; Ss in schools with the best conditions tended to show the fewest symptoms. The effects of working conditions on symptoms were relatively immediate. There may be positive mental health effects, in relation to preemployment levels, associated with teaching in benign school environments. Suggestions for future progress in …

Tabaco, Ambiente Y Salud. La Situación En Venezuela Y El Mundo, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Persistent Emotional Disorder In Children With Neurological Soft Signs, Daniel Pine, David Shaffer, Irvin Sam Schonfeld

Publications and Research

Provides clinical details in the form of 11 case vignettes from a prospective epidemiological study that found the combination of childhood 'soft' signs and anxious behavior to be a strong risk factor for adolescent emotional disorders. The original study conducted a neuropsychiatric assessment of 180 African-American adolescents (aged 16–18 yrs) who had been followed through childhood. The at-risk Ss exhibited a persistent and specific pattern of both motor abnormalities and anxiety, obsessional compulsive, or depressive symptoms over time. The form of at-risk Ss' neurological and psychiatric abnormalities is consistent with a link between motor system abnormalities and …

The Shaman's Destiny: Symptoms, Affliction, And The Re-Interpretation Of Illness Among The Taman, Jay H. Bernstein

Publications and Research

No abstract provided.

Monóxido De Carbono: Amenaza Para La Salud Pública, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Assessing Stress In Teachers: Depressive Symptoms Scales And Neutral Self-Reports Of The Work Environment, Irvin Sam Schonfeld

Publications and Research

The focal interest of this chapter on teacher stress is methodologic. The chapter enumerates a number of defects in existing measures of job stress in teachers and, concomitantly, other helping professionals. Alternative ways of measuring stress in teachers are suggested and evaluated. The use of depressive symptom scales in concert with more 'objective' measures of the work environment is discussed. An application of the proposed alternative measurement strategy is described. The wider utility of the measurement strategy is briefly described.

Disabled Does Not Mean "Not Able": A List Of Books On People Who Triumphed Over Their Illnesses And Disabilities, John A. Drobnicki

Publications and Research

This annotated booklist offers guidance on locating biographical information about people who overcame, adapted to, or triumphed over illnesses and/or disabilities.

Dimensions Of Functional Social Support And Psychological Symptoms, Irvin Sam Schonfeld

Publications and Research

In the summer following graduation a sample of 125 female college graduates (mean age = 28) completed Cohen & Wills' ISEL (1985) which includes scales measuring four social support functions: belonging (social companionship), appraisal (availability of confidants), tangible (instrumental), and self-esteem support. In the summer and fall subject status on two outcome scales was ascertained: the Psychophysiologic Symptom Scale and the Center for Epidemiologic Studies Depression Scale (CES-D). Reliability of the difference scores suggested that the ISEL scales do not measure entirely different constructs and the ISEL Self-esteem Scale is operationally redundant with the Rosenberg Self-esteem scale and the CES-D. …

Burnout In Teachers: Is It Burnout Or Is It Depression?, Irvin Sam Schonfeld

Publications and Research

No abstract provided.

The Report Of The American Heart Association Task Force On Strategies To Increase Federal Research Funding, Michael R. Rosen, Harold C. Strauss, Holly G. Atkinson, Alfred P. Fishman, Charles K. Francis, Arnold M. Katz, August M. Watanabe, Francois M. Abboud, Myron L. Weisfeldt, William F. Friedman, Bernadine P. Healy, Scott D. Ballin, Claudia Louis, Rodman D. Starke, Wallace G. Frasher

Publications and Research

No abstract provided.

Distress In A Sample Of Teachers, Irvin Sam Schonfeld

Publications and Research

Examined the links between job-related stressors and depressive and psychophysiologic symptoms and morale in 67 New York City teachers. The teachers' mean score on the Center for Epidemiologic Studies Depression Scale (CES-D) was higher than might be expected from average community residents. The CES-D and a psychophysiologic symptom scale were correlated as highly as their reliabilities would permit, indicating that they measure the same construct, nonspecific psychological distress. The level of job strain (frequency of ongoing stressors) was more closely related to psychological distress and low morale than episodic stressors, including crimes in which the teacher was …

Coping With Job-Related Stress: The Case Of Teachers, Irvin Sam Schonfeld

Publications and Research

Investigated the relationship between coping measures, psychological distress, and job-related morale among 67 teachers. Five occupational coping scales were constructed: advice seeking (ASK), positive comparisons (PCs), selective ignoring (SEL), discipline, and direct action (DIR). Multiple regression analyses with controls for social-demographic factors and adversity in the job environment indicated that ASK and DIR were most consistently related to lower (depressive and psychophysiologic) symptom levels and that PCs and DIR were most consistently related to higher morale (job satisfaction and motivation to continue in the profession). SEL appeared to buffer the impact of adverse work environments on symptoms. Findings suggest that …

Bibliography: Women, Aids, & Activism, Polly Thistlethwaite

Publications and Research

This annotated bibliography of the ACT UP/NY Women & AIDS Book Group's Women, AIDS & Activism reflects the scientific, feminist, gay, lesbian, HIV-community work that informed the book's production and ACT UP/NY's activism up to 1990. Book Group members: Marion Banzhaf, Cynthia Chris, Kim Christensen, Alexis Danzig, Risa Denenberg, Zoe Leonard, Deb Levine, Samuel Lurie, Monica Pearl, Catherine Gund, Polly Thistlethwaite, Judith Walker, and Brigitte Weil. Additional members of the original Women and AIDS Handbook Group included Jamie Bauer, Heidi Dorow, Maria Maggenti, Ellen Neipris, Ann Northrop, Sydney Pokorney, Karen Ramspacher, Maxine Wolfe, and Brian Zabcik.

Prostitution And Hiv Infection: Women, Aids, & Activism, Polly Thistlethwaite, Zoe Leonard

Publications and Research

This "Prostitution and HIV Infection" chapter of the ACT UP/NY Women & AIDS Book Group's Women, AIDS & Activism reflects the scientific, feminist, gay, lesbian, HIV-community work that informed ACT UP/NY's activism and analysis on women and HIV infection up to 1990. Book Group members: Marion Banzhaf, Cynthia Chris, Kim Christensen, Alexis Danzig, Risa Denenberg, Zoe Leonard, Deb Levine, Samuel Lurie, Monica Pearl, Catherine Gund, Polly Thistlethwaite, Judith Walker, and Brigitte Weil. Additional members of the original Women and AIDS Handbook Group included Jamie Bauer, Heidi Dorow, Maria Maggenti, Ellen Neipris, Ann Northrop, Sydney Pokorney, Karen Ramspacher, Maxine Wolfe, and …

Neurological Soft Signs And School Achievement: The Mediating Effects Of Sustained Attention, Irvin Sam Schonfeld, David Shaffer, Joseph E. Barmack

Publications and Research

Citation:

Schonfeld, I. S., Shaffer, D., & Barmack, J.E. (1989). Neurological soft signs and school achievement: The mediating effects of sustained attention. Journal of Abnormal Child Psychology, 17, 575-596. doi:10.1007/BF00917723

Prediction Of Intellectual Deficits In Children With Acute Lymphocytic Leukemia, Paul Trautman, Candace Erickson, David Shaffer, Patricia O'Connor, Annaliese Sitarz, Antonio Correra, Irvin Sam Schonfeld

Publications and Research

Possible predictors of reported lower cognitive functioning in irradiated children with acute lymphoblastic leukemia (ALL) were investigated. Thirty-four subjects, 5-14 years old, with ALL in continuous complete remission and without evidence of current or past central nervous system disease, were examined 9-110 months after diagnosis, using standard measures of intelligence and academic achievement. Subjects with a history of post-irradiation somnolence syndrome were significantly older at diagnosis than nonsomnolent subjects. Intelligence (IQ) was found to be unrelated to history of somnolence syndrome. IQ and achievement were unrelated to age at irradiation, irradiation-examination interval, and radiation dosages. The strongest predictor of IQ …