Medicine and Health Sciences Commons^™

Obesity, Physical Activity, And Mortality In A Prospective Chinese Elderly Cohort, Mary Schooling, Tai Hing Lam, Zhi Bin Li, Sai Yin Ho, Wai Man Chan, Kin Sang Ho, May Ked Tham, Benjamin J. Cowling, Gabriel M. Leung

Publications and Research

Background
In older people, it is unclear whether obesity relates to mortality, which calls into question its etiologic role in disease and its public health relevance. This apparent lack of relationship in older people could be an artifactual result of their diverse health states.

Methods
We used Cox regression analysis to determine whether the effect of body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) or physical activity on mortality varied with health status in a prospective cohort study of Chinese people 65 years or older enrolled from 1998 to 2000 at …

Longitudinal Analysis Of Censored Medical Cost Data, Onur Baser, Joseph C. Gardiner, Cathy J. Bradley, Huseyin Yuce, Charles Given

Publications and Research

This paper applies the inverse probability weighted (IPW) least-squares method to estimate the effects of treatment on total medical cost, subject to censoring, in a panel-data setting. IPW pooled ordinary-least squares (POLS) and IPW random effects (RE) models are used. Because total medical cost might not be independent of survival time under administrative censoring, unweighted POLS and RE cannot be used with censored data, to assess the effects of certain explanatory variables. Even under the violation of this independency, IPW estimation gives consistent asymptotic normal coefficients with easily computable standard errors. A traditional and robust form of the Hausman test …

Cationic Amino Acid Transport Across The Blood-Brain Barrier Is Mediated Exclusively By System Y+, Robyn L. O'Kane, Juan R. Viña, Ian Simpson, Rosa Zaragozá, Ashwini Mokashi, Richard A. Hawkins

Publications and Research

Cationic amino acid (CAA) transport is brought about by two families of proteins that are found in various tissues: Cat (CAA transporter), referred to as system y+, and Bat [broad-scope amino acid (AA) transporter], which comprises systems b0,+, B0,+, and y+L. CAA traverse the blood-brain barrier (BBB), but experiments done in vivo have only been able to examine the BBB from the luminal (blood-facing) side. In the present study, plasma membranes isolated from bovine brain microvessels were used to identify and characterize the CAA transporter(s) on both sides of the BBB. From these studies, it was concluded that system y+ …

New Vaccines Effective Against Rotavirus, Aldemaro Romero Jr., Jeannette M. Loutsch

Publications and Research

No abstract provided.

School Violence, Irvin Sam Schonfeld

Publications and Research

The purpose of this chapter is threefold. First, the chapter summarizes what is known about the prevalence of violence and weapons in U.S. schools. Second, the chapter examines theories that bear on school violence and the empirical evidence linked to those theories. Third, the chapter looks at attempts to prevent school violence and, consequently, the suffering school violence causes.

Constructing Whiteness In Health Disparities Research, Jessie Daniels, Amy J. Schulz

Publications and Research

There is a long tradition within the United States of constructing whiteness (the racial subject) against racialized others (the racial object) and in the process displacing the focus of critical analysis. Here we turn our lens to the often invisible--or at least underinterrogated--concept of whiteness within the context of the literature on racial disparities in health. Specifically, we examine how whiteness is constructed in the active literature documenting and interpreting racial disparities in health and the implications of these constructions for efforts to eradicate inequalities in health. We draw on the concepts of racial formation and "racial projects" that emphasize …

Integrating Disaster Preparedness Into A Community Health Nursing Course: One School's Experience, Mary Ireland, Emma Kontzamanis, Chantal Michel

Publications and Research

No abstract provided.

Community Reactions To Campaigns Addressing Crystal Methamphetamine Use Among Gay And Bisexual Men In New York City, Jose Nanín, Jeffrey T. Parsons, David S. Bimbi, Christian Grov, Justin T. Brown

Publications and Research

Crystal methamphetamine (aka “crystal meth”) use with high-risk sex has become an emerging health problem for gay and bisexual men in New York City since the late 1990s. Public health campaigns were eventually developed to encourage gay and bisexual men to avoid or reconsider using crystal meth. Reactions to three campaigns were measured with a cross-sectional survey administered in 2004. Among an ethnically-diverse sample of 971 gay and bisexual men, 61.8% reported seeing the campaigns. Those who reported ever using crystal meth, recent use, and recent use with sex were significantly more likely to have seen the campaigns. In …

Public Health Advocacy To Change Corporate Practices: Implications For Health Education Practice And Research, Nicholas Freudenberg

Publications and Research

Corporate practices, such as advertising, public relations, lobbying, litigation, and sponsoring scientific research, have a significant impact on the health of the people in the United States. Recently, health professionals and advocates have created a new scope of practice that aims to modify corporate practices that harm health. This article describes how corporate policies influence health and reviews recent health campaigns aimed at changing corporate behavior in six industries selected for their central role in the U.S. economy and their influence on major causes of mortality and morbidity. These are the alcohol, automobile, food, gun, pharmaceutical, and tobacco industries. The …

Bird Flu Risk Still Minimal, Aldemaro Romero Jr., Jeannette M. Loutsch

Publications and Research

No abstract provided.

Health Education’S New Frontier In Addressing Corporate Influences On Health: An Interview With Nicholas Freudenberg, Nicholas Freudenberg, Ellen Jones, Lori Dorfman

Publications and Research

Nick Freudenberg is Distinguished Professor of Public Health at Hunter College, City University of New York. For the past 25 years, he has worked with community organizations to develop, implement, and evaluate community interventions to improve the well-being of low-income urban communities. He has also worked for many years in the New York City jail, running programs to improve the transition from jail to the community, and advocating for policy changes related to jail conditions and postrelease drug treatment, health care, and housing. More recently, he has turned his attention to the role of corporate policies and practices on the …

Aaas Lecture Series On Women In Science And Engineering, Maribel Vazquez

Publications and Research

The winning essay for a Travel Award from the American Association for the Advancement in Science Women Lecture Series.

http://ehrweb.aaas.org/womeninscience/essays/vazquez.htm

Single-Payer National Health Insurance: Physicians' Views, Danny Mccormick, David U. Himmelstein, Stephanie Woolhandler, David H. Bor

Publications and Research

Background
Forty-one million Americans have no health insurance and, despite the growth of managed care, medical costs are again increasing rapidly. One proposed solution is a single-payer health care financing system with universal coverage. Yet, physicians' views of such a system have not been well studied.

Methods
We surveyed a random sample of physicians (from the American Medical Association Masterfile) in Massachusetts, regarding their views on a single-payer health care financing system and other financing and physician work-life issues that such a system might affect.

Results
Of 1787 physicians, 904 (50.6%) responded to our survey. When asked which structure would …

The Therapeutic Effects Of Exercise On Fatigue, Davina Porock, Mei Fu

Publications and Research

No abstract provided.

Visual Enhancing Of Tactile Perception In The Posterior Parietal Cortex, Tony Ro, Ruth Wallace, Judith Hagedorn, Alessandro Farnè, Elizabeth Pienkos

Publications and Research

The visual modality typically dominates over our other senses. Here we show that after inducing an extreme conflict in the left hand between vision of touch (present) and the feeling of touch (absent), sensitivity to touch increases for several minutes after the conflict. Transcranial magnetic stimulation of the posterior parietal cortex after this conflict not only eliminated the enduring visual enhancement of touch, but also impaired normal tactile perception. This latter finding demonstrates a direct role of the parietal lobe in modulating tactile perception as a result of the conflict between these senses. These results provide evidence for visual-to-tactile perceptual …

Health Beliefs And Parenting Attitudes Influence Breastfeeding Patterns Among Low-Income African-American Women, Phyllis W. Sharpe, Ayman A.E. El-Mohandes, M. Nabil El-Khorazaty, Michele Kiely, Tessa Walker

Publications and Research

OBJECTIVE: To describe breastfeeding initiation among 210 urban African-American mothers with inadequate prenatal care.

METHODS: This study is a case–control study of postpartum mothers recruited from four large urban hospitals.

RESULTS: Mothers who chose to breastfeed were more educated, employed before birth, married, and using contraception postnatally. Regression model analysis controlling for demographic differences revealed that breastfeeding was significantly associated with a higher perception of severity of illness and higher confidence in the ability of health care to prevent illness. Breastfeeding mothers were less likely to reverse parent– child roles and had a lower perception of hassle from their infant’s …

Persistence Of Virus-Reactive Serum Immunoglobulin M Antibody In Confirmed West Nile Virus Encephalitis Cases, John T. Roehrig, Denis Nash, Beth Maldin, Anne Labowitz, Denise A. Martin, Robert S. Lanciotti, Grant L. Campbell

Publications and Research

Twenty-nine laboratory-confirmed West Nile virus (WNV) encephalitis patients were bled serially so that WNV-reactive immunoglobulin (Ig) M activity could be determined. Of those patients bled, 7 (60%) of 12 had anti-WNV IgM at approximately 500 days after onset. Clinicians should be cautious when interpreting serologic results from early season WNV IgM-positive patients.

Meiotic And Mitotic Phenotypes Conferred By The Blm1-1 Mutation In Saccharomyces Cerevisiae And Msh4 Suppression Of The Bleomycin Hypersusceptibility, Georgia Anyatonwu, Ediberto Garcia, Ajay Pramanik, Marie Powell, Carol Wood Moore

Publications and Research

Oxidative damage can lead to a number of diseases, and can be fatal. The blm1-1 mutation of Saccharomyces cerevisiae confers hypersusceptibility to lethal effects of the oxidative, anticancer and antifungal agent, bleomycin. For the current report, additional defects conferred by the mutation in meiosis and mitosis were investigated. The viability of spores produced during meiosis by homozygous normal BLM1/BLM1, heterozygous BLM1/blm1-1, and homozygous mutant blm1-1/blm1-1 diploid strains was studied and compared. Approximately 88% of the tetrads derived from homozygous blm1-1/blm1-1 mutant diploid cells only produced one or two viable spores. In contrast, just one tetrad among all BLM1/BLM1 and BLM1/blm1-1 …

Up-Regulation Of Neuronal Calcium Sensor-1 (Ncs-1) In The Prefrontal Cortex Of Schizophrenic And Bipolar Patients, Phil Ok Koh, Ashiwel S. Undieh, Robert Levenson, Patricia S. Goldman-Rakic, Michael S. Lidow

Publications and Research

The delineation of dopamine dysfunction in the mentally ill has been a long-standing quest of biological psychiatry. The present study focuses on a recently recognized group of dopamine receptor- interacting proteins as possible novel sites of dysfunction in schizophrenic and bipolar patients. We demonstrate that the dorsolateral prefrontal cortex in schizophrenia and bipolar cases from the Stanley Foundation Neuropathology Consortium display significantly elevated levels of the D2 dopamine receptor desensitization regulatory protein, neuronal calcium sensor-1. These levels of neuronal calcium sensor-1 were not influenced by age, gender, hemisphere, cause of death, postmortem period, alcohol consumption, or antipsychotic and mood stabilizing …

Laboratory Response To Anthrax Bioterrorism, New York City, 2001, Michael B. Heller, Michel L. Bunning, Martin E.B. France, Debra M. Niemeyer, Leonard Peruski, Tim Naimi, Phillip M. Talboy, Patrick H. Murray, Harald W. Pietz, John Kornblum, William Oleszko, Sara T. Beatrice, Joint Microbiological Rapid Response Team, New York City Anthrax Investigation Working Group, Denis Nash

Publications and Research

In October 2001, the greater New York City Metropolitan Area was the scene of a bioterrorism attack. The scale of the public response to this attack was not foreseen and threatened to overwhelm the Bioterrorism Response Laboratory’s (BTRL) ability to process and test environmental samples. In a joint effort with the Centers for Disease Control and Prevention and the cooperation of the Department of Defense, a massive effort was launched to maintain and sustain the laboratory response and return test results in a timely fashion. This effort was largely successful. The development and expansion of the facility are described, as …

Relationship Between Low Quality-Of-Care Scores And Hmos' Subsequent Public Disclosure Of Quality-Of-Care Scores, Danny Mccormick, David U. Himmelstein, Steffie Woolhandler, Sidney M. Wolfe, David H. Bor

Publications and Research

Context Public disclosure of quality data on health maintenance organizations (HMOs) might improve public accountability, inform consumer decision making, and promote quality improvement. But, because disclosure is voluntary, some HMOs could subvert these objectives by refusing to release unfavorable data.

Objective To determine the association between HMO quality of care and withdrawal from public disclosure of quality-of-care data the subsequent year.

Design and Setting Retrospective cohort study of administrative and quality-of-care data on HMOs from the National Committee for Quality Assurance (NCQA) annual Quality Compass databases for 1997, 1998, and 1999, including Health Plan Employer Data and Information Set (HEDIS) …

Timing Of New Black Box Warnings And Withdrawals For Prescription Medications, Karen Lasser, Paul D. Allen, Steffie Woolhandler, David U. Himmelstein, Sidney M. Wolfe, David H. Bor

Publications and Research

Context Recently approved drugs may be more likely to have unrecognized adverse drug reactions (ADRs) than established drugs, but no recent studies have examined how frequently postmarketing surveillance identifies important ADRs.

Objective To determine the frequency and timing of discovery of new ADRs described in black box warnings or necessitating withdrawal of the drug from the market.

Design and Setting Examination of the Physicians' Desk Reference for all new chemical entities approved by the US Food and Drug Administration between 1975 and 1999, and all drugs withdrawn from the market between 1975 and 2000 (with or without a prior black …

Mercury Exposure And Malaria Prevalence Among Gold Miners In Pará, Brazil, Ellen K. Silbergeld, Denis Nash, Circey Trevant, G. Thomas Strickland, Jose Maria De Souza, Rui S.U. Da Silva

Publications and Research

No abstract provided.

Ipsilesional Biases In Saccades But Not Perception After Lesions Of The Human Inferior Parietal Lobule, Tony Ro, Chris Rorden, Jon Driver, Robert Rafal

Publications and Research

We examined the effects of chronic unilateral lesions to either the inferior parietal lobe, or to the dorsolateral prefrontal cortex including the frontal eye fields (FEFs), upon human visual perception and saccades in temporal-order-judgment (TOJ) tasks. Two visual events were presented on each trial, one in each hemifield at various stimulus onset asynchronies (SOAs). In the saccade task, patients moved their eyes to whichever stimulus attracted gaze first. In the perceptual-manual task, they pressed a button to indicate which stimulus was perceived first. Frontal patients showed appropriate TOJs for visual targets in both tasks. Parietal patients showed appropriate TOJs in …

The Outbreak Of West Nile Virus Infection In The New York City Area In 1999, Denis Nash, Farzad Mostashari, Annie Fine, James Miller, Daniel O'Leary, Kristy Murray, Ada Huang, Amy Rosenberg, Abby Greenberg, Margaret Sherman, Susan Wong, Marcelle Layton

Publications and Research

Background In late August 1999, an unusual cluster of cases of meningoencephalitis associated with muscle weakness was reported to the New York City Department of Health. The initial epidemiologic and environmental investigations suggested an arboviral cause.

Methods Active surveillance was implemented to identify patients hospitalized with viral encephalitis and meningitis. Cerebrospinal fluid, serum, and tissue specimens from patients with suspected cases underwent serologic and viral testing for evidence of arboviral infection.

Results Outbreak surveillance identified 59 patients who were hospitalized with West Nile virus infection in the New York City area during August and September of 1999. The median age …

Stress In 1st-Year Women Teachers: The Context Of Social Support And Coping, Irvin Sam Schonfeld

Publications and Research

The effects of adverse work environments were examined in the context of other risk/protective factors in this extension of a short-term longitudinal study involving 184 newly appointed women teachers. Regression analyses revealed that, adjusting for preemployment levels of the outcomes and negative affectivity, social support and adversity in the fall work environment were among the factors that affected spring depressive symptoms, self-esteem, job satisfaction, and motivation to teach. Support from nonwork sources was directly related to future improved symptom levels and self-esteem; supervisor and colleague support were directly related to future job satisfaction. Effects of occupational coping, professional …

The Role Of Pathology In An Investigation Of An Outbreak Of West Nile Encephalitis In New York, 1999, Wun-Ju Shieh, Jeannette Guarner, Marci Layton, Annie Fine, James Miller, Denis Nash, Grant L. Campbell, John T. Roehrig, Duane J. Gubler, Sherif R. Zaki

Publications and Research

An outbreak of encephalitis occurred in New York City in late August 1999, the first caused by West Nile virus in North America. Histopathologic and immunopathologic examinations performed on human autopsy materials helped guide subsequent laboratory and epidemiologic investigations that led to identification of the etiologic agent.

An Updated Look At Depressive Symptoms And Job Satisfaction In First-Year Women Teachers, Irvin Sam Schonfeld

Publications and Research

This report updates a longitudinal study (I. S. Schonfeld, 1992) of the effects of working conditions on newly appointed womenteachers. The update included a later graduating cohort and additional outcome measures. Moreover, women who were not fully exposed to work stressors (e.g. part-time work, change of schools) were now excluded from the analyses. Among the 184 teachers (average age 27 yrs), work environment measures were more highly correlated with future depressive symptoms, self-esteem, job satisfaction, and motivation to teach than with pre-employment counterparts of the outcomes. Regression analyses underlined the effects of the work environment on …

Nutritional Therapies For Ulcerative Colitis: Literature Review, Chart Review Study, And Future Research, Joel S. Edman, William (Bill) H. Williams, Robert C. Atkins

Publications and Research

Few clinical studies suggest a significant influence of diet or nutritional supplementation on ulcerative colitis. One reason is that ulcerative colitis, like many chronic diseases, is multifactorial. This article reviews the relevant literature and presents the results of a retrospective chart review study that was done at a complimentary medicine office.

Update: West Nile Virus Encephalitis — New York, 1999, Centers For Disease Control And Prevention, Denis Nash

Publications and Research

The West Nile virus (WNV) encephalitis outbreak continues to wane in the Northeast with the onset of cooler temperatures and continued vector-control operations. This report updates the progress of the ongoing investigation. Since the last published update (1), five additional domestic human cases and one international case have been identified. As of October 19, 56 (31 confirmed and 25 probable) cases of WNV infection have been identified, including seven deaths (Figure 1). The date of onset of the latest cases was September 22. The international case was a Canadian citizen who had visited the New York City (NYC) area in …