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Articles 331 - 360 of 2151
Full-Text Articles in Medicine and Health Sciences
Sleep Disorders Medicine, Thomas Roth
Sleep Disorders Medicine, Thomas Roth
Henry Ford Hospital Medical Journal
No abstract provided.
Familial Childhood Sleep Apnea, Robert M. Wittig, Frank J. Zorick, Timothy A. Roehrs, Jeanne M. Sicklesteel, Thomas Roth
Familial Childhood Sleep Apnea, Robert M. Wittig, Frank J. Zorick, Timothy A. Roehrs, Jeanne M. Sicklesteel, Thomas Roth
Henry Ford Hospital Medical Journal
We report four siblings who had polysomnographically documented sleep apnea. Two presented with the typical clinical picture of sleep apnea syndrome including daytime somnolence and snoring, had repetitive obstructive apneic episodes during sleep, and were effectively treated with upper airway surgery. The other two were asymptomatic and showed infrequent apneic episodes during sleep. This family illustrates the distinction between the sleep apnea syndrome and infrequent apneic episodes during sleep. The sleep apnea syndrome is associated with daytime symptomatology and requires treatment. The presence of apneic episodes during sleep in all four siblings has implications regarding the predisposing factors (eg, upper …
Anticoagulant Therapy, Antithrombotic Therapy, Pulmonary Embolism, And The Henry Ford Hospital Perspective, Paul D. Stein
Anticoagulant Therapy, Antithrombotic Therapy, Pulmonary Embolism, And The Henry Ford Hospital Perspective, Paul D. Stein
Henry Ford Hospital Medical Journal
No abstract provided.
Clinical Manifestations Of Acute Pulmonary Embolism: Henry Ford Hospital Experience, A Five-Year Review, Kenneth V. Leeper Jr., John Popovich Jr., Deborah Adams, Paul D. Stein
Clinical Manifestations Of Acute Pulmonary Embolism: Henry Ford Hospital Experience, A Five-Year Review, Kenneth V. Leeper Jr., John Popovich Jr., Deborah Adams, Paul D. Stein
Henry Ford Hospital Medical Journal
Clinical findings of 112 patients with angiographically proven pulmonary embolism over a five-year period were analyzed. Recent immobilization, chronic heart disease, deep venous thrombosis, malignancy, and recent surgery were the most frequent predisposing factors. Only 5% had no identifiable risk factors. Presenting syndromes were circulatory collapse (25%), pulmonary infarction (59%), and uncomplicated pulmonary embolism (18%). Dyspnea and pleuritic chest pain were the predominant symptoms. The combination of dyspnea, pleuritic chest pain, and hemoptysis occurred in 23% of the patients. The most frequent signs were tachypnea, tachycardia, and rales. Most of the patients demonstrated arterial oxygen tension (PaO2) between 50 and …
Disseminated Strongyloides Stercoralis And Aspergillus Fumigatus Presenting As Diffuse Interstitial Pneumonitis In A Steroid-Dependent Chronic Obstructive Pulmonary Disease Patient, Larry Tankanow, Michael S. Eichenhorn
Disseminated Strongyloides Stercoralis And Aspergillus Fumigatus Presenting As Diffuse Interstitial Pneumonitis In A Steroid-Dependent Chronic Obstructive Pulmonary Disease Patient, Larry Tankanow, Michael S. Eichenhorn
Henry Ford Hospital Medical Journal
We describe a patient with long-standing steroid-dependent chronic obstructive pulmonary disease who was admitted with new diffuse interstitial pulmonary infiltrates. Strongyloides stercoralis was present in the sputum and stool and responded to treatment. However, complicating disseminating Aspergillus fumigatus infection eventuated in the patient's death. Strongyloides stercoralis infection should be considered in patients with relevant exposure history, and complicating fungal and gram-negative bacterial infections which such patients may develop should be suspected.
Cancer Mortality Among Residents Of Huron, Sanilac, And Tbscola Counties As Compared To Other Michigan Residents, 1971-1985, Jennifer A. Booms, William Benish
Cancer Mortality Among Residents Of Huron, Sanilac, And Tbscola Counties As Compared To Other Michigan Residents, 1971-1985, Jennifer A. Booms, William Benish
Henry Ford Hospital Medical Journal
Age-adjusted cancer mortality rates in the "Thumb" area of Michigan (Huron, Sanilac, and Tuscola counties) were compared with those for the rest of the state from 1971 to 1985. Comparisons were made after partitioning the mortality data on the basis of the patient's sex, year of death (1971 to 1975, 1976 to 1980, or 1981 to 1985), and site of primary tumor. International Classification of Diseases categories were combined to define 29 cancer site groups. The analysis was limited to the white population. The major observation was a consistently lower mortality rate of lung cancer in the Thumb area than …
Enteric-Coated Fenoprofen In Large-Joint Osteoarthritis, Gilbert B. Bluhm, Harris H. Macilwain, Walter W. Offen
Enteric-Coated Fenoprofen In Large-Joint Osteoarthritis, Gilbert B. Bluhm, Harris H. Macilwain, Walter W. Offen
Henry Ford Hospital Medical Journal
Enteric-coated fenoprofen was compared with standard fenoprofen (Nalfon, Dista, Indianapolis, IN) in a randomized, double-blind, parallel, three-month trial of 113 outpatients (mean age, 64 years) with large-joint osteoarthritis. A previous study showed that enteric coating of fenoprofen reduces gastrointestinal microbleeding and may offer a safety advantage. Both treatments provided statistically significant improvement in pain measures (tenderness on pressure, pain at rest, pain with weight-bearing activity, and pain on passive motion). Adverse experiences were similar with both treatments and of an expected type, severity, and incidence for nonsteroidal anti-inflammatory drugs. Enteric-coated fenoprofen was found to be as effective and safe as …
Malignant Lymphoma Presenting In Gluteal Muscles: Case Report And Brief Review Of The Literature, Roberta Sonnino, Angelos A. Kambouris
Malignant Lymphoma Presenting In Gluteal Muscles: Case Report And Brief Review Of The Literature, Roberta Sonnino, Angelos A. Kambouris
Henry Ford Hospital Medical Journal
No abstract provided.
Potency Of Current Levothyroxine Preparations Evaluated By High-Performance Liquid Chromatography, Sheldon S. Stoffer, Walter E. Szpunar
Potency Of Current Levothyroxine Preparations Evaluated By High-Performance Liquid Chromatography, Sheldon S. Stoffer, Walter E. Szpunar
Henry Ford Hospital Medical Journal
Ten different levothyroxine products manufactured by six companies were analyzed by high-performance liquid chromatography. Although nine products met the United States Pharmacopeia requirements, one product was found to have only 47% of expected potency. Until these products become more uniform, we would not recommend interchangeability of levothyroxine preparations.
Jack S. Guyton, Md, Cornelius E. Mccole
Jack S. Guyton, Md, Cornelius E. Mccole
Henry Ford Hospital Medical Journal
No abstract provided.
Editorial: Responsibilities Of Authorship: Justification Of The Multiauthored Scientific Paper, Sarah Whitehouse, Raymond C. Mellinger
Editorial: Responsibilities Of Authorship: Justification Of The Multiauthored Scientific Paper, Sarah Whitehouse, Raymond C. Mellinger
Henry Ford Hospital Medical Journal
No abstract provided.
Aspects Of Endocrinology, Michael Kleerekoper, Raymond C. Mellinger
Aspects Of Endocrinology, Michael Kleerekoper, Raymond C. Mellinger
Henry Ford Hospital Medical Journal
No abstract provided.
An Overview Of Magnetic Resonance Imaging Of The Appendicular Musculoskeletal System, Sharon C. Siegel, Allan M. Haggar, Jerry W. Froelich, Burton I. Ellis
An Overview Of Magnetic Resonance Imaging Of The Appendicular Musculoskeletal System, Sharon C. Siegel, Allan M. Haggar, Jerry W. Froelich, Burton I. Ellis
Henry Ford Hospital Medical Journal
No abstract provided.
Pituitary Metastasis: Lung Cancer Presenting As Bitemporal Hemianopsia With Diabetes Insipidus And Anterior Pituitary Deficiency, A. Keith Cryar, Jay Morgan, Jack P. Rock, Max Wisgerhof
Pituitary Metastasis: Lung Cancer Presenting As Bitemporal Hemianopsia With Diabetes Insipidus And Anterior Pituitary Deficiency, A. Keith Cryar, Jay Morgan, Jack P. Rock, Max Wisgerhof
Henry Ford Hospital Medical Journal
Symptoms and signs of pituitary disease are rarely the first manifestations of malignancy originating in another organ. We present a case which exemplifies the key points that suggest a diagnosis of metastatic pituitary disease. Our patient's diagnosis was adenocarcinoma of the lung with a metastasis to the intrasellar and suprasellar regions, which caused diabetes insipidus, anterior pituitary deficiency, and visual field defects. The metastasis had a dumbbell appearance and extended from the sella turcica into the suprasellar region. Diabetes insipidus was the initial clinical manifestation of lung cancer in this patient. A metastasis to the pituitary should be suspected if …
Pregnancy Following Sequential Bromocriptine Therapy In A Hyperprolactinemic Subject, Malachi J. Mckenna, M. Saeed-Uz-Zafar, Raymond C. Mellinger
Pregnancy Following Sequential Bromocriptine Therapy In A Hyperprolactinemic Subject, Malachi J. Mckenna, M. Saeed-Uz-Zafar, Raymond C. Mellinger
Henry Ford Hospital Medical Journal
Regular menses were maintained in a 26-year-old woman with a prolactinoma by sequential bromocriptine therapy given for either five or 14 days of the menstrual cycle. She conceived promptly when desired.
Comparison Of Four High-Sensitivity Immunoradiometric Assays For Thyrotropin And Results Of Preliminary Clinical Studies, Malachi J. Mckenna, Earl Goad, Mohini Pimputkar, Carolyn S. Feldkamp
Comparison Of Four High-Sensitivity Immunoradiometric Assays For Thyrotropin And Results Of Preliminary Clinical Studies, Malachi J. Mckenna, Earl Goad, Mohini Pimputkar, Carolyn S. Feldkamp
Henry Ford Hospital Medical Journal
New immunoradiometric assays (IRMAs) that detect low concentrations of thyroid-stimulating hormone (TSH) have recently become available for routine diagnostic use. These new assays have the putative advantage over conventional radioimmunoassay in that they can distinguish hyperthyroidism from euthyroidism by the finding of a serum TSH below the normal limit. In the present study we sought to evaluate four of these kits according to analytical performance characteristics and clinical utility. All IRM As could detect TSH at a concentration substantially below the lower limit of normal and thus effectively identify hyperthyroid samples. Although differences in the performance characteristics were found, all …
Neurobehavioral Symptoms In Mild Primary Hyperparathyroidism: Related To Hypercalcemia But Not Improved By Parathyroidectomy, Gregory G. Brown, Richard C. Preisman, Michael Kleerekoper
Neurobehavioral Symptoms In Mild Primary Hyperparathyroidism: Related To Hypercalcemia But Not Improved By Parathyroidectomy, Gregory G. Brown, Richard C. Preisman, Michael Kleerekoper
Henry Ford Hospital Medical Journal
The neurobehavioral symptomatology of severe primary hyperparathyroidism (PHPT) has been thoroughly described. Less is known about more mild cases. We evaluated 34 patients with mild PHPT and followed 19 for an average of six months. Of those cases followed, ten had parathyroidectomy (PTX). Patients with no neurobehavioral abnormalities had the lowest serum calcium levels (10.9 ± 0.88 mg/dL), patients with signs of affective disorder had intermediate levels (11.25 ± 0.66 mg/dL), and patients with signs of cerebral dysfunction had the highest levels (12.17 ± 1.17 mg/dL). Serum calcium significantly correlated with motor speed, psychomotor speed, fluid intelligence, and short term …
Prolonged Remission Of Cushing's Disease Following Bromocriptine Therapy, Malachi J. Mckenna, Marc Linares, Raymond C. Mellinger
Prolonged Remission Of Cushing's Disease Following Bromocriptine Therapy, Malachi J. Mckenna, Marc Linares, Raymond C. Mellinger
Henry Ford Hospital Medical Journal
A 33-year-old woman developed hypercorticism of fulminant onset following delivery of a full-term, normal child. An ectopic hormone-producing neoplasm was excluded by extensive studies. Pituitary dependent hypercorticism of intermediate lobe origin was suggested on the basis of onset following pregnancy, failure of Cortisol suppression by high-dose dexamethasone, hyperresponsiveness of prolactin to thyrotropin-releasing hormone stimulation, and reduction in adrenocorticotropin titers following oral administration of bromocriptine. Initial remission of disease achieved with bromocriptine was followed by recurrence on discontinuation of the agent. However, complete remission which occurred following a prolonged course of bromocriptine has persisted for a total of 22 months.
Hypothalamic Hypogonadotropic Hypogonadism In An Adolescent Male: A Rare Manifestation Of Aqueductal Stenosis, Robert J. Wilson, Max Wisgerhof
Hypothalamic Hypogonadotropic Hypogonadism In An Adolescent Male: A Rare Manifestation Of Aqueductal Stenosis, Robert J. Wilson, Max Wisgerhof
Henry Ford Hospital Medical Journal
No abstract provided.
Naltrexone Does Not Affect Adrenal Steroidogenesis In Women With Hirsutism/Oligomenorrhea, Jeffrey A. Jackson, Thomas J. Wincek, Jose F. Pliego
Naltrexone Does Not Affect Adrenal Steroidogenesis In Women With Hirsutism/Oligomenorrhea, Jeffrey A. Jackson, Thomas J. Wincek, Jose F. Pliego
Henry Ford Hospital Medical Journal
We studied the effects of the oral opiate receptor antagonist naltrexone on basal and ACTH-stimulated adrenal steroid levels in six women with hirsutism/oligomenorrhea and preexisting elevation of serum dehydroepiandrosterone sulfate. One of the six patients met the criteria for partial 3-β-hydroxysteroid dehydrogenase deficiency. No statistical differences were detected in steroid levels or ratios before and after 14 days of 50 mg/day of naltrexone. Thus, we find no support for the hypothesis that opioid peptides acting through opiate receptors (predominantly μ subtype) modulate the abnormal adrenal androgen secretion seen in these women with hirsutism/oligomenorrhea.
Hyperthyroidism Due To A Thyrotropin-Secreting Pituitary Microadenoma, Jeffrey A. Jackson, Mitchell Smigiel, John F. Green Jr.
Hyperthyroidism Due To A Thyrotropin-Secreting Pituitary Microadenoma, Jeffrey A. Jackson, Mitchell Smigiel, John F. Green Jr.
Henry Ford Hospital Medical Journal
A 52-year-old man presented with elevated thyroid hormone levels and an inappropriately normal serum thyrotropin (TSH) (4.0 μU/mL: normal 0.5 to 6.0 μU/mL). Computed tomography suggested an intrasellar mass without radiographic sellar enlargement. Serum alpha-subunit was elevated with flat responses of both alpha-subunit and TSH to thyrotropin-releasing hormone. Transsphenoidal adenomectomy resulted in clinical and biochemical cure with subsequent development of hypothyroidism with otherwise preserved anterior pituitary function. Pathologic studies demonstrated an 8 mm typical thyrotroph cell adenoma. Early diagnosis of such tumors requires a high index of clinical suspicion and may be facilitated in the future by utilization of highly …
Primary Hyperparathyroidism And Associated Neoplasms, Angelos A. Kambouris, Mohammed R. Ansari, Gary B. Talpos
Primary Hyperparathyroidism And Associated Neoplasms, Angelos A. Kambouris, Mohammed R. Ansari, Gary B. Talpos
Henry Ford Hospital Medical Journal
No abstract provided.
Effects Of Weight Reduction, Exercise, And Diet Modification On Lipids And Apolipoproteins A-L And B In Severely Obese Persons, J. David Fachnie, Craig C. Foreback
Effects Of Weight Reduction, Exercise, And Diet Modification On Lipids And Apolipoproteins A-L And B In Severely Obese Persons, J. David Fachnie, Craig C. Foreback
Henry Ford Hospital Medical Journal
We assessed the lipid and apolipoprotein effects of hypocaloric dieting, increased physical activity, and dietary modification in severely overweight adults (body mass index [BMI] 43.05 kg/m-). The 34 women and four men enrolled in the ambulatory weight control program donated blood before, during, and after hypocaloric dieting (420 kcal/day). Mean values before dieting included cholesterol of 223 mg/dL, high-density lipoprotein (HDL) cholesterol of 43 mg/dL, and cholesterol/HDL cholesterol of 5.90. This placed our subjects at high risk for coronary artery disease. Other values included triglycerides of 138 mg/dL, apolipoprotein A-l of 152 mg/dL. and apolipoprotein B/apolipoprotein A-l of 0.64. Significant …
Renal Involvement In Type 2 Diabetes Mellitus: A Clinicopathologic Study Of The Henry Ford Hospital Experience, Francis Dumler, Vijay Kumar, Raymond N. Romanski, Pedro Cortes, Nathan W. Levin
Renal Involvement In Type 2 Diabetes Mellitus: A Clinicopathologic Study Of The Henry Ford Hospital Experience, Francis Dumler, Vijay Kumar, Raymond N. Romanski, Pedro Cortes, Nathan W. Levin
Henry Ford Hospital Medical Journal
To better understand renal dysfunction in type 2 diabetes mellitus, we studied the clinical and autopsy findings in comparable cohorts of 108 diabetic and 77 nondiabetic patients. In the diabetic group, no differences were noted between black and white patients in blood glucose concentrations, mean blood pressure, or the prevalence of diabetic glomerulosclerosis. However, the prevalence of renal insufficiency was significantly greater (P = 0.002) in black diabetics (58%) than in white diabetics (35%). black controls (28%), and white controls (20%). Logistic regression analysis demonstrated a significant association of renal insufficiency with diabetes (P = 0.006) and race (P = …
Primary Aldosteronism At Henry Ford Hospital In The 1980s, Max Wisgerhof
Primary Aldosteronism At Henry Ford Hospital In The 1980s, Max Wisgerhof
Henry Ford Hospital Medical Journal
This report describes the experience with the diagnosis and treatment of primary aldosteronism at Henry Ford Hospital since 1980. Of the 28 patients who received the diagnosis. 13 had unilateral primary aldosteronism and 15 had idiopathic hyperaldosteronism. Individual cases are used to demonstrate clinical points. The clue to the presence of primary aldosteronism in a hypertensive patient is hypokalemia. The diagnosis is established by showing 1) high plasma aldosterone after intravenous saline or high urinary aldosterone after treatment with sodium chloride orally, and 2) low stimulated plasma renin activity. Treatment with potassium supplement should be given during the testing. Unilateral …
Management Of Extramedullary Plasmacytomas, James A. Bonner, Jadranka Dragovic, Michael P. Abrash
Management Of Extramedullary Plasmacytomas, James A. Bonner, Jadranka Dragovic, Michael P. Abrash
Henry Ford Hospital Medical Journal
From 1965 through 1982. 12 patients with solitary, biopsy-proven extramedullary plasmacytomas (EMPs) were treated at our institution with surgery alone or biopsy followed by radiation therapy. The median age of the patients was 67 years, and the median-follow-up was 58 months. Of the seven patients who were treated by primary surgery, three developed recurrent or distant disease. Five patients underwent biopsy followed by radiation therapy, and none of their tumors progressed. Our series and a review of the literature show that occasionally EMPs will incompletely regress even after high doses of radiation (greater than 65 Gy); however, we recommend that …
Unusual Lymphomas Developing In Chronic Lymphocytic Leukemia, Sundara B. K. Raman, Sheikh M. Saeed, Joseph P. Abraham
Unusual Lymphomas Developing In Chronic Lymphocytic Leukemia, Sundara B. K. Raman, Sheikh M. Saeed, Joseph P. Abraham
Henry Ford Hospital Medical Journal
We report three patients with chronic lymphocytic leukemia (CLL) who developed malignant lymphomas of unusual character and modes of presentation. Two of the patients had received low doses of chlorambucil for several years before they developed malignant lymphoma, diffuse, large cell type (LCL). In one of these patients LCL manifested as a grossly evident osteolytic lesion. In the second patient LCL developed initially as a localized lesion in the iliac bone. Both patients died within a few weeks after LCL was diagnosed. The third patient, who was found to have CLL during a routine examination, did not receive any therapy …