Medicine and Health Sciences Commons^™

Integrated Profiling Identifies Itgb3bp As Prognostic Biomarker For Hepatocellular Carcinoma, Qiuli Liang, Chao Tan, Feifei Xiao, Fuqiang Yin, Meiliang Liu, Lei Lei, Liuyu Wu, Yu Yang, Jennifer Hui Juan Tan, Shun Liu, Xiaoyun Zeng

Faculty Publications

Hepatocellular carcinoma (HCC) is a highly malignant tumor. In this study, we sought to identify a novel biomarker for HCC by analyzing transcriptome and clinical data. The R software was used to analyze the differentially expressed genes (DEGs) in the datasets GSE74656 and GSE84598 downloaded from the Gene Expression Omnibus database, followed by a functional annotation. A total of 138 shared DEGs were screened from two datasets. They were mainly enriched in the “Metabolic pathways” pathway (Padj = 8.21E-08) and involved in the carboxylic acid metabolic process (Padj = 0.0004). The top 10 hub genes were found by protein-protein interaction …

Impact Of Adverse Childhood Events On The Psychosocial Functioning Of Children Affected By Parental Hiv In Rural China, Jordan Ezell, Sayward E. Harrison, Yanping Jiang, Xiaoming Li Ph.D.

Faculty Publications

Introduction: Children affected by parental HIV are more likely than unaffected peers to experience trauma and are at-risk for negative psychological and social outcomes. This study aimed to examine the relationship between adverse childhood events and psychosocial functioning among children affected by parental HIV.

Methods: A total of 790 children ages 6–17 from Henan, China were enrolled in a longitudinal, randomized controlled trial of a resilience-based psychosocial intervention. At baseline, children reported on numerous psychosocial factors, including trauma exposure, symptoms of anxiety and depression, and peer social functioning. We used linear regression analysis to test the direct effect of trauma …

Time-Varying Insomnia Symptoms And Incidence Of Cognitive Impairment And Dementia Among Older Us Adults, Nicholas V. Resciniti, Valerie Yelverton, Bezawit Eyob Kase, Jiajia Zhang, Matthew C. Lohman

Faculty Publications

There is conflicting evidence regarding the association between insomnia and the onset of mild cognitive impairment (MCI) or dementia. This study aimed to evaluate if time-varying insomnia is associated with the development of MCI and dementia. Data from the Health and Retirement Study (n = 13,833) from 2002 to 2014 were used (59.4% female). The Brief Insomnia Questionnaire was used to identify insomnia symptoms which were compiled in an insomnia severity index, ranging from 0 to 4. In analysis, participants’ symptoms could vary from wave-to-wave. Dementia was defined using results from the Health and Retirement Study (HRS) global cognitive …

Propranolol Sensitizes Vascular Sarcoma Cells To Doxorubicin By Altering Lysosomal Drug Sequestration And Drug Efflux, Jhuma Saha, Jong Hyuk Kim, Clarissa N. Amaya, Caleb M. Witcher, Ali Khammanivong, Derek M. Korpela, David R. Brown, Josephine Taylor, Brad A. Bryan, Erin B. Dickerson

Faculty Publications

Angiosarcoma is a rare cancer of blood vessel–forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resistance. We previously identified a subset of doxorubicin-resistant cells in human angiosarcoma and canine hemangiosarcoma cell lines that exhibit high lysosomal accumulation of doxorubicin. Hydrophobic, weak base chemotherapeutics, like doxorubicin, are known to sequester within lysosomes, promoting resistance by limiting drug accessibility to cellular targets. Drug synergy between the beta adrenergic receptor (β-AR) antagonist, propranolol, and multiple chemotherapeutics has been documented in vitro, and …

Values And Other Decisional Factors Regarding Treatment Of Hypercalcaemia Of Malignancy: A Systematic Review Protocol, Aya Bassatne, Maya Rahme, Thomas Piggott, Hassan Murad, Layal Hneiny, Ghada El-Hajj Fuleihan

Faculty Publications

Introduction Hypercalcaemia of malignancy (HCM) is the second most common cause of hypercalcaemia and is associated with significant morbidity and mortality. Several treatment options are available including pharmacological therapy with bisphosphonates, denosumab, glucocorticoids and calcimimetics, as well as conventional therapy with hydration and possibly calcitonin. While guidelines have previously considered treatment effects, no guideline has yet considered a range of contextual factors impacting recommendations for the management. The aim of this study was to summarise the available evidence on important decisional factors for the development of guidelines for the treatment of HCM. These include patient’s values and preferences, cost, acceptability, …

Effects Of Moderate Sleep Restriction During 8-Week Calorie Restriction On Lipoprotein Particles And Glucose Metabolism, Joshua R. Sparks, Ryan R. Porter, Shawn D. Youngstedt, Kimberly P. Bowyer, J. Larry Durstine, Xuewen Wang

Faculty Publications

Study Objectives

This study examined how glucose, glucose regulatory hormones, insulin sensitivity, and lipoprotein subclass particle concentrations and sizes change with sleep restriction during weight loss elicited by calorie restriction.

Methods

Overweight or obese adults were randomized into an 8-week calorie restriction intervention alone (CR, n = 12; 75% female; body mass index = 31.4 ± 2.9 kg/m2) or combined with sleep restriction (CR+SR, n = 16; 75% female; body mass index = 34.5 ± 3.1 kg/m2). Participants in both groups were given the same instructions to reduce calorie intake. Those in the CR+SR group were instructed to reduce their …

Deep Brain Stimulation For Obsessive-Compulsive Disorder: Real World Experience Post-Fda-Humanitarian Use Device Approval, Lora Kahn, Brianne Sutton, Helena R. Winston, Aviva Abosch, John A. Thompson, Rachel E. Davis

Faculty Publications

While case series have established the efficacy of deep brain stimulation (DBS) in treating obsessive-compulsive disorder (OCD), it has been our experience that few OCD patients present without comorbidities that affect outcomes associated with DBS treatment. Here we present our experience with DBS therapy for OCD in patients who all have comorbid disease, together with the results of our programming strategies. For this case series, we assessed five patients who underwent ventral capsule/ventral striatum (VC/VS) DBS for OCD between 2015 and 2019 at the University of Colorado Hospital. Every patient in this cohort exhibited comorbidities, including substance use disorders, eating …

Validity Of A Four-Item Household Water Insecurity Experiences Scale For Assessing Water Issues Related To Health And Well-Being, Sera L. Young, Joshua D. Miller, Edward A. Frongillo Jr., Godfred O. Boateng, Zeina Jamaluddine, Torsten B. Neilands

Faculty Publications

We sought to determine whether a shortened version of the 12-item Household Water Insecurity Experiences (HWISE) Scale, which measures water insecurity equivalently in low- and middle-income countries (LMICs), is valid for broad use. Using data from 9,261 households in 25 LMICs, subsets of candidate items were evaluated on their predictive accuracy, criterion validity, and sensitivity-specificity. A subset with items assessing "worry," "changing plans," "limited drinking water," and "inability to wash hands" because of problems with water (range: 0-12) were highly correlated with full HWISE Scale scores (correlation coefficient: 0.949-0.980) and introduced minimal additional error (root mean square error: 2.13-2.68). Criterion …

Moving Beyond Giving Free Food: Specific Targeting And Tailoring In Response To Child Food Insecurity, Maryah Stella Fram, Edward A. Frongillo Jr.

Faculty Publications

No abstract provided.

Megf10 Deficiency Impairs Skeletal Muscle Stem Cell Migration And Muscle Regeneration, Chengcheng Li, Dorianmarie Vargas-Franco, Madhurima Saha, Rachel M. Davis, Kelsey A. Manko, Isabelle Draper, Christina A. Pacak, Peter B. Kang

Faculty Publications

Biallelic loss-of-function MEGF10 mutations lead to MEGF10 myopathy, also known as early onset myopathy with areflexia, respiratory distress, and dysphagia (EMARDD). MEGF10 is expressed in muscle satellite cells, but the contribution of satellite cell dysfunction to MEGF10 myopathy is unclear. Myofibers and satellite cells were isolated and examined from Megf10 and wild-type mice. A separate set of mice underwent repeated intramuscular barium chloride injections. Megf10 muscle satellite cells showed reduced proliferation and migration, while Megf10 mouse skeletal muscles showed impaired regeneration. Megf10 deficiency is associated with impaired muscle regeneration, due in part to defects in satellite cell function. Efforts to …

Testing Encoding Specificity And The Diagnostic Feature-Detection Theory Of Eyewitness Identification, With Implications For Showups, Lineups, And Partially Disguised Perpetrators, Curt Carlson, Jacob A. Hemby, Alex R. Wooten, Alyssa R. Jones

Faculty Publications

The diagnostic feature-detection theory (DFT) of eyewitness identification is based on facial information that is diagnostic versus non-diagnostic of suspect guilt. It primarily has been tested by discounting non-diagnostic information at retrieval, typically by surrounding a single suspect showup with good fillers to create a lineup. We tested additional DFT predictions by manipulating the presence of facial information (i.e., the exterior region of the face) at both encoding and retrieval with a large between-subjects factorial design (N = 19,414). In support of DFT and in replication of the literature, lineups yielded higher discriminability than showups. In support of encoding specificity, …

Less Common Bacterial, Fungal And Viral Infections: Review Of Management In The Pregnant Patient, Alyssa P. Gould, Hana R. Winders, Kayla R. Stover, P Brandon Bookstaver, Brooke Griffin, Christopher M. Bland, Lea S. Eiland, Milena Murray

Faculty Publications

This review is a comprehensive summary of treatment options for pregnant patients with less common bacterial, fungal, and viral infections. It offers guidance to clinicians based on the most recently published evidence-based research and expert recommendations. A search of MEDLINE (inception to March 2021) and the CDC website was performed. Liposomal amphotericin B is the preferred therapy for cryptococcosis, histoplasmosis, oesophageal candidiasis, and coccidioidomycosis, especially during the first trimester due to teratogenic concerns with azole antifungals. For oral candidiasis, clotrimazole troches or miconazole mucoadhesive buccal tablets are recommended. A β-lactam antimicrobial is preferred over doxycycline for various manifestations of Lyme …

Consequences To Patients, Clinicians, And Manufacturers When Very Serious Adverse Drug Reactions Are Identified (1997-2019): A Qualitative Analysis From The Southern Network On Adverse Reactions (Sonar), Charles L. Bennett M.D., Ph.D., Shamia Hoque, Nancy Olivieri, Matthew A. Taylor, David Aboulafia, Courtney Lubaczewski, Andrew C. Bennett, Jay Vemula, Benjamin Schooley, Bartlett J. Witherspoon, Ashley C. Godwin, Paul S. Ray, Marc Fishman, Georgne Herring, Anne Ventrone, Juan Aldaco, William J. Hrushesky, John Restaino, Henrik S. Thomsen, Robert Marx, Et. Al.

Faculty Publications

Background

Methods

Genetic Risk Factors For Alzheimer’S Disease In Racial/Ethnic Minority Populations In The U.S.: A Scoping Review, Lindsey Rubin, Lucy Annang Ingram Phd, Nicholas V. Resciniti, Brianna Ashford-Carroll, Katherine Henrietta Leith, Aubrey Rose, Stephanie Ureña, Quentin Mccollum, Daniela B. Friedman

Faculty Publications

As the United States (U.S.) population rapidly ages, the incidence of Alzheimer's Disease and Related Dementias (ADRDs) is rising, with racial/ethnic minorities affected at disproportionate rates. Much research has been undertaken to test, sequence, and analyze genetic risk factors for ADRDs in Caucasian populations, but comparatively little has been done with racial/ethnic minority populations. We conducted a scoping review to examine the nature and extent of the research that has been published about the genetic factors of ADRDs among racial/ethnic minorities in the U.S. Using an established scoping review methodological framework, we searched electronic databases for articles describing peer-reviewed empirical …

Restriction Of Access To Deep Brain Stimulation For Refractory Ocd: Failure To Apply The Federal Parity Act, Rachel Davis, James Giordano, D Brian Hufford, Sameer A. Sheth, Peter Warnke, Alik S. Widge, R Mark Richardson, Joshua M. Rosenow, Peter Justin Rossi, Eric A. Storch, Helena Winston, Joanne Zboyan, Darin D. Dougherty, Kelly D. Foote, Wayne K. Goodman, Nicole C. Mclaughlin, Steven Ojemann, Steven Rasmussen, Aviva Abosch, Michael S. Okun

Faculty Publications

No abstract provided.

A Method For Cultivation, Fractionation, And Metal Determination To Evaluate Metal Removal By The Combination Of Nps And Bacteria, Xiufeng Cao, Liang Xu, Alan W. Decho, Jamie Lead

Faculty Publications

Metals being released into the environment are posing an increasing risk to both environments and public health. Developing improved approaches to remove these metals from the environment is urgent. A current publication discovered that metal bioremediation was significantly improved by nanoparticles (NPs), and the remediation duration was shortened. However, there is no relevant method for the preparation and evaluation of this novel idea. Hence, we developed this method for bacteria -EPS (Extracellular Polymeric Substances) cultivation, bacteria sub-cellular fractionation, and metal determinations in cultivating solution, EPS and different fractions of bacteria to evaluate metal removal by the combination of NPs and …

Responding To The Call: Building A Training Program To Diversify The Academy In Alzheimer’S Disease Research, Lucy Annang Ingram Phd, Marvella E. Ford, Christiana L. Johnson, Brianna Ashford-Carroll, Quentin Mccollum, Daniela B. Friedman, Sue E. Levkoff

Faculty Publications

Alzheimer's disease and related dementias (ADRD) are at the forefront of the United States (US) public health agenda due to their tremendous human and financial burden. Further, disproportionately high ADRD rates among racial/ethnic minorities require incorporating the unique perspectives of racially and ethnically diverse scientists, which will necessitate diversifying the scientific workforce that investigates disparities in aging. The purpose of this paper is to describe the training and mentorship initiatives of the National Institute on Aging (NIA)-funded Carolina Center on Alzheimer's Disease and Minority Research, emphasizing lessons learned from our engagement with underrepresented minority and minoritized (URM) Scientists. We highlight …

Nutritional Approach For Increasing Public Health During Pandemic Of Covid-19: A Comprehensive Review Of Antiviral Nutrients And Nutraceuticals, Vahideh Ebrahimzadeh-Attari, Ghodratollah Panahi, James R. Hébert Scd, Alireza Ostadrahimi, Maryam Saghafi-Asl, Neda Lotfi-Yaghin, Behzad Baradaran

Faculty Publications

Background: The novel coronavirus (COVID-19) is considered as the most life-threatening pandemic disease during the last decade. The individual nutritional status, though usually ignored in the management of COVID-19, plays a critical role in the immune function and pathogenesis of infection. Accordingly, the present review article aimed to report the effects of nutrients and nutraceuticals on respiratory viral infections including COVID-19, with a focus on their mechanisms of action.

Methods: Studies were identified via systematic searches of the databases including PubMed/ MEDLINE, ScienceDirect, Scopus, and Google Scholar from 2000 until April 2020, using keywords. All relevant clinical and experimental studies …

The Effect Of Amplification On Cortical Synchrony In Children With Auditory Neuropathy Spectrum Disorder, Garrett Cardon, Anu Sharma

Faculty Publications

Objective: The benefit of hearing aids as a clinical intervention strategy for children with Auditory Neuropathy Spectrum Disorder (ANSD) remains controversial. The goal of this study was to determine whether amplification through hearing aid use increased cortical phase synchrony in children with ANSD. Design: Using inter-trial coherence (ITC) of the EEG signal as a measure of cortical phase-locking, we examined differences in cortical phase synchrony in children with ANSD using both cross-sectional and longitudinal designs. Study Sample: Participants in the cross-sectional and longitudinal portions of the study included 58 and 16 children with clinical diagnoses of ANSD, respectively. Results: Results …

A Perceptual Study Of Cross-Language Influence On Vocal Fry Use In Women Exposed To Two Languages, Todd A. Gibson, Connie Summers

Faculty Publications

Cross-linguistic influence has been observed across all domains of language. However, nothing is known about the role of cross-linguistic influence in bilingual speakers’ use of vocal fry. Several recent studies have identified an upsurge in the use of vocal fry among female speakers of American English. We sought to identify cross-linguistic influence in vocal fry use by women living in the US and exposed to both English and Spanish. Participants were categorized as functionally monolingual in English (n = 25), functionally monolingual in Spanish (n =23) and relatively balanced bilingual (n = 10) based on responses to language experience questionnaires. …

Is Germline Gene Editing Exceptional?, Myrisha S. Lewis

Faculty Publications

Advances in gene editing have recently received significant scientific and media attention. Gene editing, especially CRISPR-Cas9, has revived multiple longstanding ethical debates, including debates related to parental autonomy, health disparities, disability perspectives, and racial and economic inequalities. Germline, or heritable, gene editing generates several newer, neglected bioethical debates, including those about the shared human germline and whether there is a "line" that humans should not cross.

This Article addresses several interrelated ethical and legal questions related to germline gene editing. Those questions address why, if at all, germline gene editing needs to be regulated and, if germline gene editing needs …

文理人 (Wenliren: Humanities, Science, Human), Lui Lam

Faculty Publications

No abstract provided.

A Longitudinal Study Of Interprofessional Education In Graduate Students From Rehabilitation Sciences, Sarah Elkington, Connie Summers, Celia Pechak, Patricia Lara, Francesca Hernandez

Faculty Publications

• Date Presented Accepted for AOTA INSPIRE 2021 but unable to be presented due to online event limitations. A longitudinal study evaluated the effects of interprofessional education (IPE) experiences on 71 rehabilitation science graduate students' perceptions of interprofessional collaboration (IPC). Physical therapy, OT, and speech-language pathology students rated their perceptions of IPC and their knowledge of other disciplines' roles across their first year of graduate school. IPE experiences are an important aspect of professional preparation. Primary Author and Speaker: Sarah Elkington Contributing Authors: Connie Summers, Celia Pechak, Patricia Lara, and Francesca Hernandez

Repeated Word Production Is Inconsistent In Both Aphasia And Apraxia Of Speech, Tyson G. Harmon, Katarina L. Haley, Kevin T. Cunningham, Adam Jacks, Jessica D. Richardson, Peter E. Turkeltaub

Faculty Publications

Purpose: There is persistent uncertainty about whether sound error consistency is a valid criterion for differentiating between apraxia of speech (AOS) and aphasia with phonemic paraphasia. The purpose of this study was to determine whether speakers with a profile of aphasia and AOS differ in error consistency from speakers with aphasia who do not have AOS. By accounting for differences in overall severity and using a sample size well over three times that of the largest study on the topic to date, our ambition was to resolve the existing controversy.

Method: We analyzed speech samples from 171 speakers …

Spoken Discourse Assessment And Analysis In Aphasia: An International Survey Of Current Practices, Tyson G. Harmon, Brielle C. Stark, Manaswita Dutta, Laura L. Murray, Davida Fromm, Lucy Bryant

Faculty Publications

Purpose

Spoken discourse analysis is commonly employed in the assessment and treatment of people living with aphasia, yet there is no standardization in assessment, analysis, or reporting procedures, thereby precluding comparison/meta-analyses of data and hindering replication of findings. An important first step is to identify current practices in collecting and analyzing spoken discourse in aphasia. Thus, this study surveyed current practices, with the goal of working toward standardizing spoken discourse assessment first in research settings with subsequent implementation into clinical settings.

Method

A mixed-methods (quantitative and qualitative) survey was publicized to researchers and clinicians around the globe who have collected …

Kinematic And Acoustic Changes To Vowels And Diphthongs In Bite Block Speech, Christopher Dromey, Michelle Richins, Tanner Low

Faculty Publications

Purpose: We examined the effect of bite block insertion (BBI) on lingual movements and formant frequencies in corner vowel and diphthong production in a sentence context. Method: Twenty young adults produced the corner vowels (/u/, /ɑ/, /æ/, /i/) and the diphthong /ɑɪ/ in sentence contexts before and after BBI. An electromagnetic articulograph measured the movements of the tongue back, middle, and front. Results: There were significant decreases in the acoustic vowel articulation index and vowel space area following BBI. The kinematic vowel articulation index decreased significantly for the back and middle of the tongue but not for the front. There …

3d Fusion Between Fluoroscopy Angiograms And Spect Myocardial Perfusion Images To Guide Percutaneous Coronary Intervention, Haipeng Tang, Robert R. Bober, Chen Zhao, Chaoyang Zhang, Huiqing Zhu, Zhuo He, Zhihui Xu, Weihua Zhou

Faculty Publications

Background

Percutaneous coronary intervention (PCI) in stable coronary artery disease (CAD) is commonly triggered by abnormal myocardial perfusion imaging (MPI). However, due to the possibilities of multivessel disease, serial stenoses and variability of coronary artery perfusion distribution, an opportunity exists to better align anatomic stenosis with perfusion abnormalities to improve revascularization decisions. This study aims to develop a multi-modality fusion approach to assist decision-making for PCI.

Methods and Results

Coronary arteries from fluoroscopic angiography (FA) were reconstructed into 3D artery anatomy. Left ventricular (LV) epicardial surface was extracted from SPECT. The artery anatomy and epicardial surface were non-rigidly fused. The …

Perceived Vulnerability To Covid-19 Infection From Event Attendance: Results From Louisiana, Usa, Two Weeks Preceding The National Emergency Declaration, Ran Li, Bingcheng Yang, Jerrod Penn, Bailey Houghtaling, Juan Chen, Witoon Prinyawiwatkul, Brian E. Roe, Danyi Qi

Faculty Publications

Background: Individual perceptions of personal and national threats posed by COVID-19 shaped initial response to the pandemic. The aim of this study was to investigate the changes in residents' awareness about COVID-19 and to characterize those who were more aware and responsive during the early stages of the pandemic in Louisiana.

Methods: In response to the mounting threat of COVID-19, we added questions to an ongoing food preference study held at Louisiana State University from March 3rd through March 12th, 2020. We asked how likely it was that the spread of the coronavirus will cause a national public health crisis …

Evaluating A Technology-Mediated Hpv Vaccination Awareness Intervention: A Controlled, Quasi-Experimental, Mixed Methods Study, Heather M. Brandt, Beth Sundstrom, Courtney M. Monroe, Gabrielle Turner-Mcgrievy, Chelsea Larsen, Melissa Stansbury, Karen Magradey, Andrea Gibson, Delia Smith West

Faculty Publications

College-aged women and men are an important catch-up population for human papillomavirus (HPV) vaccination interventions. Limited research has explored technology-mediated HPV vaccination awareness interventions aimed at college students. The purpose was to evaluate a novel, technology-mediated, social media-based intervention to promote HPV vaccination among college students. A controlled, quasi-experimental, mixed methods study examined the feasibility of a technology-based intervention among two undergraduate classes ( = 58) at a public university in the southeastern United States of America. Classes were randomized to receive one of two cancer prevention programs (i.e., HPV vaccination (intervention) or healthy weight (control)). Both programs contained eight …

Information Uncertainty: A Correlate For Acute Stress Disorder During The Covid-19 Outbreak In China, Danhua Lin, Daniela B. Friedman Ph.D., Shan Qiao Ph.D., Cheuk Chi Tam, Xiaoyan Li, Xiaoming Li Ph.D.

Faculty Publications

Background: Individuals’ stress in responding to the current COVID-19 pandemic may be exacerbated by information uncertainty driven by inconsistent, unverified, and conflicting news from various sources. The current study aims to test if information uncertainty during the COVID-19 outbreak was related to acute stress disorder (ASD) over and above other psychosocial stressors.

Methods: An anonymous online survey was conducted with 7800 college students throughout China from January 31 through February 11, 2020. Existing scales were modified to measure ASD and six potential stressors including information uncertainty during the COVID-19 outbreak. Hierarchical regression analysis was conducted to assess the unique association …