Medicine and Health Sciences Commons^™

Volatile Profiling Reveals Intracellular Metabolic Changes In Aspergillus Parasticus: Vea Regulates Branched Chain Amino Acid And Ethanol Metabolism, Ludmila V. Roze, Anindya Chanda, Maris Laivenieks, Randolph M. Beaudry, Katherine A. Artymovich, Anna V. Koptina, Deena W. Awad, Dina Valeeva, Arthur D. Jones, John E. Linz

Faculty Publications

Background: Filamentous fungi in the genus Aspergillus produce a variety of natural products, including aflatoxin, the most potent naturally occurring carcinogen known. Aflatoxin biosynthesis, one of the most highly characterized secondary metabolic pathways, offers a model system to study secondary metabolism in eukaryotes. To control or customize biosynthesis of natural products we must understand how secondary metabolism integrates into the overall cellular metabolic network. By applying a metabolomics approach we analyzed volatile compounds synthesized by Aspergillus parasiticus in an attempt to define the association of secondary metabolism with other metabolic and cellular processes.

Results: Volatile compounds were examined using solid …

Prolonged Injustice In Urban America, Jametta Magwood, Edith M. Williams, Saundra H. Glover

Faculty Publications

Environmental inequality is the suggestion that the working class, the poor, persons of color, and ultimately the economically disadvantaged are subjected to living conditions that may prove to be hazardous both personally, professionally, and also to the infrastructure of the urban communities that these people inhabit. These injustices affect not only housing but education, quality healthcare access, and access to employment. This article investigates the distinct relationship of environmental inequalities imposed in urban communities that are promoted by a prominent institution: the government. It has been suggested that the government is primarily controlled by individuals who are incapable of identifying …

Lessons From A Life Well-Lived, Harold W. Kohl Iii, Steven N. Blair

Faculty Publications

No abstract provided.

Specialty Care Use In Us Patients With Chronic Diseases, Jessica D. Bellinger, Rahnuma M. Hassan, Patrick A. Rivers, Qiang Cheng, Edith M. Williams, Saundra H. Glover

Faculty Publications

Despite efforts to eliminate health disparities, racial, ethnic, and geographic groups continue lag behind their counterparts in health outcomes in the United States. The purpose of this study is to determine variation in specialty care utilization by chronic disease status. Data were extracted from the Commonwealth Fund 2006 Health Care Quality Survey (n = 2475). A stratified minority sample design was employed to ensure a representative sample. Logistic regression was used in analyses to predict specialty care utilization in the sample. Poor perceived health, minority status, and lack of insurance was associated with reduced specialty care use and chronic disease …

Cesarean And Vbac Rates Among Immigrant Vs. Native-Born Women: A Retrospective Observational Study From Taiwan Cesarean Delivery And Vbac Among Immigrant Women In Taiwan, Jung-Chung Fu, Sudha Xirasagar, Jihong Liu, Janice C. Probst

Faculty Publications

Background:Cultural and ethnic roots impact women’s fertility and delivery preferences This study investigated whether the likelihood of cesarean delivery, primary cesarean, and vaginal delivery after cesarean (VBAC) varies by maternal national origin.

Mehods: We conducted a nation-wide, population-based, observational study using secondary data from Taiwan. De-identified data were obtained on all 392,246 singleton live births (≥500 g; ≥20 weeks) born to native-born Taiwanese, Vietnamese and mainland Chinese-born mothers between January 1 2006 and December 31 2007 from Taiwan’s nation-wide birth certificate data. Our analytic samples consisted of the following: for overall cesarean likelihood 392,246 births, primary cesarean 336,766 (excluding …

Louder Speech Leads To Greater Intelligibility Improvements Than Amplification Of Habitual Speech In Parkinson’S Disease, Christopher Dromey

Faculty Publications

Effects of loud and amplified speech on sentence and word intelligibility in Parkinson disease.

It’S Not A Small World After All: Regulating Obesity Globally, Eloisa Rodriguez-Dod

Faculty Publications

The rate of obesity and overweight among the world population has increased dramatically over the past several years in both adults and children. Childhood obesity is a critical health care concern. There have been well-publicized efforts to regulate children‘s obesity both in the U.S. and abroad through such measures as mandated nutritional school lunch programs.

This article focuses, however, on a less examined area of regulation—the recent worldwide efforts to curb obesity among adults. The regulations discussed in this article include measures proposed or adopted by either administrative agencies or legislative bodies, whether on a local or national level. The …

Vocal Fold Bowing In Elderly Male Monozygotic Twins: A Case Study, Kristine Tanner, Cara Sauder, Susan L. Thibeault, Christopher Dromey, Marshall E. Smith

Faculty Publications

Objectives: This study examined case histories, diagnostic features, and treatment response in two 79-year-old male monozygotic (identical) twins with vocal fold bowing, exploring both genetic and environmental factors.
Study Design: Case study.
Methods: DNA concordance was examined via cheek swab. Case histories, videostroboscopy, auditory- and visual-perceptual assessment, electromyography, acoustic measures, and Voice Handicap ratings were undertaken. Both twins underwent surgical intervention and subsequent voice therapy.
Results: Monozygosity was confirmed for DNA polymorphisms, with 10 of 10 concordance for STR DNA markers. For both twins, auditory and visual-perceptual assessments indicated severe bowing, hoarseness and breathiness, although Twin 1 was judged to …

Louder Speech Leads To Greater Intelligibility Improvements Than Amplification Of Habitual Speech In Parkinson Disease, Christopher Dromey

Faculty Publications

Amplification may be helpful in improving speech intelligibility for some speakers with Parkinson disease. Because the gain used in the present study was limited to the dB increase from habitual to loud speech, it is unclear how performance might increase with higher amplification levels. Increases in the signal to noise ratio in the present study only account for about one third to one half of the intelligibility improvements that accompany loud speech. Thus, loud speech differs from habitual speech in more than just its amplitude. Articulation appears to play a lesser role in these improvements, whereas source spectral changes may …

Parent Involvement In End-Of-Life Care And Decision Making In The Newborn Intensive Care Unit: An Integrative Review, Lacey M. Eden, Lynn Clark Callister

Faculty Publications

Survival rates for very preterm and critically ill infants are increasing, raising complex ethical issues for health-care providers and parents who face the challenge of making end-of-life decisions for newborns. The purpose of this integrative literature review was to evaluate parental involvement in end-of-life care and decision making for their infant in the newborn intensive care unit. Findings revealed that establishing good relationships and clear communication between health-care providers and parents builds trust and eases stress placed on parents making decisions about the care of their infant. Palliative care programs provide support for parents and facilitate their decision making. Parents …

Exploring The Impact Of Race On Mental Health Service Utilization Among African Americans And Whites With Severe Mental Illness, Michelle Hampton, Linda Chafetz, Mary White

Faculty Publications

BACKGROUND: Disparities among African Americans and Whites with severe mental illness have been identified in numerous studies. Yet it remains unknown if disparities are associated with race or other vulnerabilities common to this population. OBJECTIVES: This study used the Behavioral Model for Vulnerable Populations to examine mental health service utilization among 155 African Americans and Whites with severe mental illness for 12 months after discharge from a residential crisis program. DESIGN: This cross-sectional study was a secondary analysis of data from a randomized trial. RESULTS: Race did not emerge as a significant predictor of mental health service utilization. Factors associated …

Bilingual Performance On Nonword Repetition In Spanish And English, Connie Summers, Thomas M. Bohman, Ronald B. Gillam, Elizabeth D. Pena, Lisa M. Bedore

Faculty Publications

Background: Nonword repetition (NWR) involves the ability to perceive, store, recall and reproduce phonological sequences. These same abilities play a role in word and morpheme learning. Cross-linguistic studies of performance on NWR tasks, word learning, and morpheme learning yield patterns of increased performance on all three tasks as a function of age and language experience. These results are consistent with the idea that there may be universal information-processing mechanisms supporting language learning. Because bilingual children’s language experience is divided across two languages, studying performance in two languages on NWR could inform one’s understanding of the relationship between information processing and …

Bidirectional Interference Between Speech And Postural Stability In Individuals With Parkinson's Disease, Christopher Dromey, Eon Jarvis, Stuart Sondrup, Shawn Nissen, K. Bo Foreman, Leland E. Dibble

Faculty Publications

Because people frequently talk while engaged in other activities, and because Parkinson's disease (PD) is known to diminish multi-tasking performance, we examined dual task interference between speaking and postural stability in 9 individuals with PD, 7 age-matched and 10 healthy young controls. Participants repeated a target utterance and performed a rise to toes task in both single and dual task conditions. Diphthong transitions were measured from audio recordings and postural variables reflecting planning, coordination, and stability were derived from a multi-camera motion capture system and force plate recordings. Thus, sensitive measures of both control groups for the isolated postural task, …

Trends In Body Fat, Body Mass Index And Physical Fitness Among Male And Female College Students, Peter Pribis, Carol A. Burtnack, Sonya O. Mckenzie, Jerome Thayer

Faculty Publications

There have been many publications in recent years reporting on the quantity of physical activity among college students using indirect indicators such as steps walked per day or time spent on physical activities. The purpose of this study was to describe the trends of physical fitness related to BMI and body fat among university students between 1996 and 2008. The results showed a significant decline in the average fitness levels measured as an estimation of VO2max for male and female students (p < 0.001 for both sexes). The linear trend for BMI by years was not significant for both sexes (p for males = 0.772, p for females = 0.253). On average, in the last 13 years, % body fat was increasing 0.513%/year for males and 0.654%/year for females. There is a significant indirect correlation between the student's VO2max levels and % body fat, r = -0.489; p < 0.001 for males; and r = -0.416, p < 0.001 for females. Approximately 23.9% of the variance in the VO2max levels in males and 17.3% in females can be explained by the variance in % body fat. The results support recent findings that physical fitness among college students is declining and body fatness is increasing. © 2010 by the authors.

A Comparison Of The Wellbeing Of Orphans And Abandoned Children Ages 6–12 In Institutional And Community-Based Care Settings In 5 Less Wealthy Nations, Kathryn Whetten, Jan Ostermann, Rachel A. Whetten, Brian W. Pence, Karen O'Donnell, Lynne C. Messer, Nathan M. Thielman, The Positive Outcomes For Orphans (Pofo) Research Team

Faculty Publications

Background

Leaders are struggling to care for the estimated 143,000,000 orphans and millions more abandoned children worldwide. Global policy makers are advocating that institution-living orphans and abandoned children (OAC) be moved as quickly as possible to a residential family setting and that institutional care be used as a last resort. This analysis tests the hypothesis that institutional care for OAC aged 6–12 is associated with worse health and wellbeing than community residential care using conservative two-tail tests.

Methodology

The Positive Outcomes for Orphans (POFO) study employed two-stage random sampling survey methodology in 6 sites across 5 countries to identify 1,357 …

The 600-Step Program For Type I Diabetes Self-Management In Youth: The Magnitude Of The Self-Management Task, Ronald D. Coffen

Faculty Publications

This article demonstrates the complexity of the type 1 diabetes regimen and describes the physician's role in safely promoting self-management of diabetes by youth. Literature describing type 1 diabetes and the required regimen, issues related to regimen adherence by youth, demonstration of the magnitude of the regimen, and implications for physicians are addressed. A task analysis and tool for physicians is presented that contains over 600 tasks. Given the magnitude of the regimen, issues related to the physician's promotion of the gradual transfer of regimen control to youth are illustrated. The importance of understanding broad areas of the regimen (eg, …

Prospective Associations Between Objective Measures Of Physical Activity And Fat Mass In 12-14 Year Old Children: The Avon Longitudinal Study Of Parents And Children (Alspac), Chris J. Riddoch, Sam D. Leary, Andy R. Ness, Steven N. Blair, Kevin Deere, Calum Mattocks, Alex Griffiths, George Davey Smith, Kate Tilling

Faculty Publications

Objective: To investigate associations between physical activity at age 12 and subsequent adiposity at age 14.

Design: Prospective birth cohort study with data collected between 2003 and 2007.

Setting: Original recruitment in 1991-2 of 14,541 pregnant women living in the former County of Avon (United Kingdom).

Participants: At age 12, 11,952 children were invited to attend the research clinic. Of these, 7159 attended, and 4150 (1964 boys, 2186 girls) provided sufficient data on exposure, outcome, and confounding variables.

Main outcome measure: Fat mass at age 14, measured by dual emission x ray absorptiometry, associated with physical activity at age 12, …

Current Substance Use Behavior Among Severely Mentally Ill Individuals Diagnosed With Hiv And Hcv, Michelle Hampton, Linda Chafetz, Carmen Portillo

Faculty Publications

BACKGROUND: Infection with HIV and HCV is higher among severely mentally ill (SMI) individuals than the general population. The literature addressing prevention focuses primarily on sexual risk, though substance-related risk is significant. Insufficient data is available about substance use behavior in this population to formulate effective secondary prevention interventions. METHODS: This cross-sectional study was a secondary analysis of a RCT. Subjects reporting a diagnosis of HIV/HCV (reporters) were compared to non-reporters. Data were extracted from interviews that included the Addiction Severity Index (ASI). Data were analyzed using logistic regression. RESULTS: Of 275 subjects, 64(23.3%) reported a HIV/HCV diagnosis. Compared to …

Computer-Based Cognitive Interventions For Persons With Dementia: Feasibility And Outcomes, Nidhi Mahendra, Allegra Apple, Susan Carroll, Adithya Chandregowda

Faculty Publications

No abstract provided.

Barriers Influencing Minority Clients’ Access To Speech Language Pathology Services. Poster, Nidhi Mahendra, Katie Schoneman, Nisha Engineer

Faculty Publications

No abstract provided.

A Review Of The National Physical Activity Plans Of Six Countries, Daniel B. Bornstein, Russell R. Pate, Michael Pratt

Faculty Publications

Background: Architects of the United States national physical activity plan can benefit from a thorough understanding of national physical activity plans from other nations. The purpose of this paper was to search for and analyze comprehensive national physical activity plan documents that can best inform the development of the U.S. plan. Methods: Electronic databases were searched for national physical activity plan documents, yielding 252 documents from 56 countries. After eliminating documents that were not written in English, did not address physical activity primarily, and did not meet our definition of a national physical activity plan, we were left with physical …

A National Physical Activity Plan For The United States, Russell R. Pate

Faculty Publications

No abstract provided.

A Cost Analysis Of A Physical Activity Intervention For Older Adults, Erik J. Groessl, Robert M. Kaplan, Steven N. Blair, W. Jack Rejeski, Jeffrey A. Katula, Abby C. King, Roger A. Fielding, Nancy W. Glynn, Marco Pahor

Faculty Publications

We examined the costs of a physical activity (PA) and an educational comparison intervention. 424 older adults at risk for mobility disability were randomly assigned to either condition. The PA program consisted of center-based exercise sessions 3x weekly for 8 weeks, 2x weekly for weeks 9 to 24 and weekly behavioral counseling for 10 weeks. Optional sessions were offered during maintenance weeks (25-52). The comparison intervention consisted of weekly education meetings for 24 weeks, and then monthly for 6 months. Cost analyses were conducted from the "payer's" perspective, with a 1-year time horizon. Intervention costs were estimated by tracking personnel …

Role Of Lifestyle And Aging On The Longitudinal Change In Cardiorespiratory Fitness, Andrew S. Jackson, Xuemei Sui, James R. Hébert, Timothy S. Church, Steven N. Blair

Faculty Publications

Background - Cardiorespiratory fitness (CRF) in adults decreases with age and is influenced by lifestyle. Low CRF is associated with risk of diseases and the ability of older persons to function independently. We defined the longitudinal rate of CRF decline with aging and the association of aging and lifestyle with CRF.

Methods - We studied a cohort of 3429 women and 16,889 men, aged 20 to 96 years, from the Aerobics Center Longitudinal Study who completed 2 to 33 health examinations from 1974 to 2006. The lifestyle variables were body mass index, self-reported aerobic exercise, and smoking behavior. Cardiorespiratory fitness …

Quality Health Information On The Internet: Developing A Diabetes Pathfinder For The Chinese Population, Ana D. Cleveland, Jodi Philbrick, Xuequn Pan, Xinyu Yu, Jiangping Chen, Marty O'Neill, Lisa Smith

Faculty Publications

A Web-based bilingual diabetes information pathfinder was created to help the Chinese population access quality health information on the Internet as part of a collaborative outreach project in the Dallas-Fort Worth area. A survey was conducted to identify the demographics, Internet usage, health information needs, and preferences for training sessions of the Chinese population. Breast cancer, diabetes, and hepatitis B were the top three diseases of interest. The process of developing the pathfinder is described from start to finish, and it can serve as a model for the development of others. Pathfinder training sessions also were held. Taylor & Francis …

Designing A Simulation For Student Evaluation Using Scriven's Key Evaluation Checklist, Shelly Jensen Reed

Faculty Publications

Human patient simulation use has increased dramatically in nursing education over the past 10 years, with many benefits. One advantage is that it allows students to learn by practicing skills in a risk-free environment, with immediate faculty feedback. Another benefit is that it prepares and ensures the competence of student nurses, leading to improved patient safety outcomes. Student opinions gathered in a survey of nursing schools and simulator centers favored use of competency evaluation using simulation in at least some circumstances. As little research concerning use of simulation to evaluate student competency can be found, an established guide such as …

Acoustic And Spectral Patterns In Young Children's Stop Consonant Productions, Shawn L. Nissen, Robert Allen Fox

Faculty Publications

The aim of this study was to examine the acoustic and spectral patterns of stop articulation in the speech of pre-pubescent children. A set of voiceless stop consonants, /ptk/, produced by a group of adults and typically developing children 3-5 years of age were examined in terms of multiple acoustic and spectral parameters. Findings indicated that, with the exception of spectral kurtosis, the acoustic and spectral characteristics of the stop productions varied significantly as a function of place of articulation and vowel context. Sex-specific differences in spectral slope, mean, and skewness were found for the 5-year-old and adult speakers. Such …

Student Satisfaction With Simulation Experiences, Angeline Abdo, Patricia K. Ravert

Faculty Publications

Background: Some nursing schools use patient simulators to simulate patient scenarios.

Methods: Nursing students participated in five sessions using a patient simulator and then completed a questionnaire related to their experiences.

Results: Participants felt the experiences recreated real-life situations, tested their clinical decision-making, prepared them for the “real-life” clinical setting, and increased their confidence when in the clinical setting.

Conclusions: Patient simulator experiences enhance learning. Further research regarding student perceptions and instrument validation would contribute to an increased understanding of the use of patient simulators in nursing education.

Sedentary Behavior And Obesity In A Large Cohort Of Children, Jonathan A. Mitchell, Calum Mattocks, Andy R. Ness, Sam D. Leary, Russell R. Pate, Marsha Dowda, Steven N. Blair, Chris Riddoch

Faculty Publications

The purpose of this study was to examine the association between sedentary behavior and obesity among 12-year-old children, while adjusting for moderate-to-vigorous physical activity (MVPA) and other potential confounding variables.

Cross-sectional analyses were carried out with data from 5434 children who participated in the Avon Longitudinal Study of Parents and Children (ALSPAC). Fat mass was derived using dual x-ray emission absorptiometry (DXA), and height and weight measurements were used to calculate body mass index (BMI; kg/m²). The children wore an accelerometer for seven days. The cut points for sedentary behavior and MVPA were ≤199 cpm and ≥3600 cpm, …

Food Insecurity Among Homeless And Marginally Housed Individuals Living With Hiv/Aids In San Francisco, Sheri D. Weiser, David R. Bangsberg, Susan Kegeles, Kathleen Ragland, Margot B. Kushel, Edward A. Frongillo Jr.

Faculty Publications

Food insecurity is a risk factor for both HIV transmission and worse HIV clinical outcomes. We examined the prevalence of and factors associated with food insecurity among homeless and marginally housed HIV-infected individuals in San Francisco recruited from the Research on Access to Care in the Homeless Cohort. We used multiple logistic regression to determine socio-demographic and behavioral factors associated with food insecurity, which was measured using the Household Food Insecurity Access Scale. Among 250 participants, over half (53.6%) were food insecure. Higher odds of food insecurity was associated with being white, low CD4 counts, recent crack use, lack of …