Medicine and Health Sciences Commons^™

Caloric Restriction, Aerobic Exercise Training And Soluble Lectin-Like Oxidized Ldl Receptor-1 Levels In Overweight And Obese Post-Menopausal Women, Tina E. Brinkley, Xuewen Wang, Noriaki Kume, Hirokazu Mitsuoka, Barbara J. Nicklas

Faculty Publications

Background—Elevated circulating levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) have been observed in obese persons and are reduced by weight loss. However, it is not known if combining caloric restriction (CR) with exercise training is better in reducing sLOX-1 levels than CR alone.

Objective—We examined whether the addition of aerobic exercise to a weight loss intervention differentially affects sLOX-1 levels in 61 abdominally obese postmenopausal women randomly assigned to a CR only (n=22), CR + moderate-intensity exercise (n=22), or CR + vigorous intensity exercise (n=17) intervention for 20 weeks. The caloric deficit was ~2,800 kcal/week for …

Control Of Reflexive Saccades Following Hemispherectomy, Patricia A. Reuter-Lorenz, Troy M. Herter, Daniel Guitton

Faculty Publications

Individuals who have undergone hemispherectomy for treatment of intractable epilepsy offer a rare and valuable opportunity to examine the ability of a single cortical hemisphere to control oculomotor performance. We used peripheral auditory events to trigger saccades, thereby circumventing dense postsurgical hemianopia. In an antisaccade task, patients generated numerous unintended short-latency saccades toward contralesional auditory events, indicating pronounced limitations in the ability of a single hemicortex to exert normal inhibitory control over ipsilateral (i.e., contralesional) reflexive saccade generation. Despite reflexive errors, patients retained an ability to generate correct antisaccades in both directions. The prosaccade task revealed numerous contralesional express saccades, …

Hub City Steps: Methods And Early Findings From A Community-Based Participatory Research Trial To Reduce Blood Pressure Among African Americans, Jamie M. Zoellner, Carol L. Connell, Michael B. Madson, Bo Wang, Vickie Blakely Reed, Elaine F. Molaison, M. Kathleen Yadrick

Faculty Publications

Background: Community-based participatory research (CBPR) has been recognized as an important approach to develop and execute health interventions among marginalized populations, and a key strategy to translate research into practice to help reduce health disparities. Despite growing interest in the CBPR approach, CBPR initiatives rarely use experimental or other rigorous research designs to evaluate health outcomes. This behavioral study describes the conceptual frameworks, methods, and early findings related to the reach, adoption, implementation, and effectiveness on primary blood pressure outcomes.

Methods: The CBPR, social support, and motivational interviewing frameworks are applied to test treatment effects of a two-phased CBPR walking …

Differential Gene Expression Of Foxo1, Id1, And Id3 Between Young And Older Men And Associations With Muscle Mass And Function, Thomas W. Buford, Matthew B. Cooke, Brian D. Shelmadine, Geoffrey M. Hudson, Liz L. Redd, Darryn S. Willoughby

Faculty Publications

Background and aims: Aging is associated with significant losses of skeletal muscle mass and function. Numerous biochemical molecules have been implicated in the development of these age-related changes, however evidence from human models is sparse. Assessment of transcript expression is useful as it requires minimal tissue and may potentially be used in clinical trials. This study aimed to compare mRNA expression of proteolytic genes in skeletal muscle of young (18–35 yrs) and older (55–75 yrs) men.

Methods: Muscle tissue was obtained from young (n=14, 21.35±01.03 yrs) and older (n=13, 63.85±1.83 yrs) men using percutaneous biopsy, and transcript expression was quantified …

Cardiometabolic Results From An Armband-Based Weight Loss Trial, John C. Sieverdes, Xuemei Sui, Gregory A. Hand, Vaughn W. Barry, Sarah Wilcox, Rebecca A. Meriwether, James W. Hardin, Amanda C. Mcclain, Steven N. Blair

Faculty Publications

Purpose: This report examines the blood chemistry and blood pressure (BP) results from the Lifestyle Education for Activity and Nutrition (LEAN) study, a randomized weight loss trial. A primary purpose of the study was to evaluate the effects of real-time self-monitoring of energy balance (using the SenseWear^TM Armband, BodyMedia, Inc Pittsburgh, PA) on these health factors.

Methods: 164 sedentary overweight or obese adults (46.8 ± 10.8 years; BMI 33.3 ± 5.2 kg/m²; 80% women) took part in the 9-month study. Participants were randomized into 4 conditions: a standard care condition with an evidence-based weight loss manual (n …

Tryptophan Degradation In Women With Breast Cancer: A Pilot Study, Debra E. Lyon, Jeanne M. Walter, Angela R. Starkwater, Christine M. Schubert, Nancy L. Mccain

Faculty Publications

Background: Altered tryptophan metabolism and indoleamine 2,3-dioxygenase activity are linked to cancer development and progression. In addition, these biological factors have been associated with the development and severity of neuropsychiatric syndromes, including major depressive disorder. However, this biological mechanism associated with both poor disease outcomes and adverse neuropsychiatric symptoms has received little attention in women with breast cancer. Therefore, a pilot study was undertaken to compare levels of tryptophan and other proteins involved in tryptophan degradation in women with breast cancer to women without cancer, and secondarily, to examine levels in women with breast cancer over the course of chemotherapy. …

Electronic Feedback In A Diet- And Physical Activity-Based Intervention For Weight Loss: A Randomized Controlled Trial, Sara L. Shuger, Vaughn W. Barry, Xuemei Sui, Amanda C. Mcclain, Gregory A. Hand, Sarah Wilcox, Rebecca A. Meriwether, James W. Hardin, Steven N. Blair

Faculty Publications

Background: The SenseWear^TM Armband (SWA) (BodyMedia, Inc. Pittsburgh, PA) is a physical activity and lifestyle monitor that objectively and accurately measures free-living energy balance and sleep and includes software for self-monitoring of daily energy expenditure and energy intake. The real-time feedback of the SWA can improve individual self-monitoring and, therefore, enhance weight loss outcomes.

Methods: We recruited 197 sedentary overweight or obese adults (age, 46.8 ± 10.8 y; body mass index (BMI), 33.3 ± 5.2 kg/m²; 81% women, 32% African-American) from the greater Columbia, South Carolina area. Participants were randomized into 1 of 4 groups, a self-directed …

Bmi Trajectories During The Transition To Older Adulthood: Persistent, Widening, Or Diminishing Disparities By Ethnicity And Education?, Katrina M. Walsemann, Jennifer A. Ailshire

Faculty Publications

Previous research has produced inconsistent results on whether education and ethnic disparities in BMI persist, widen, or diminish over time. We investigate how education and ethnicity, independently and conditionally, influence BMI trajectories during the transition to older adulthood. Employing random coefficient modeling, we analyzed 8 biennial waves of data (1992-2006) from the Health and Retirement Study, a nationally representative longitudinal study of individuals born between 1931 and 1941. After adjusting for health behaviors and health status, education and ethnic disparities in BMI persisted for most groups, but narrowed between high-educated white men and both low-educated Hispanic men and high-educated black …

Physical Activity And Sedentary Activity Patterns Among Children And Adolescents: A Latent Class Analysis Approach, Carrie D. Patnode, Leslie A. Lytle, Darin J. Erickson, John R. Sirard, Daheia J. Barr-Anderson, Mary Story

Faculty Publications

Background: While much is known about the overall levels of physical activity and sedentary activity among youth, few studies have attempted to define clusters of such behaviors. The purpose of this study was to identify and describe unique classes of youth based on their perception in a variety of physical activity and sedentary behaviors. Methods: Latent class analysis was used to characterize segments of youth based on patterns of self-reported and accelerometer-measured participation in 12 behaviors. Children and adolescents (N =720) from 6th-11th grade were included in the analysis. Differences in class membership were examined using multinomial logistic …

Trends Over 5 Decades In U.S. Occupation-Related Physical Activity And Their Associations With Obesity, Timothy S. Church, Diana M. Thomas, Catrine Tudor-Locke, Peter T. Katzmarzyk, Conrad P. Earnest, Ruben Q. Rodarte, Corby K. Martin, Steven N. Blair, Claude Bouchard

Faculty Publications

Background: The true causes of the obesity epidemic are not well understood and there are few longitudinal population-based data published examining this issue. The objective of this analysis was to examine trends in occupational physical activity during the past 5 decades and explore how these trends relate to concurrent changes in body weight in the U.S.

Methodology/Principle Findings: Analysis of energy expenditure for occupations in U.S. private industry since 1960 using data from the U.S. Bureau of Labor Statistics. Mean body weight was derived from the U.S. National Health and Nutrition Examination Surveys (NHANES). In the early 1960's almost half …

State Methamphetamine Precursor Policies And Changes In Small Toxic Lab Methamphetamine Production, Duane C. Mcbride, Yvonne Terry-Mcelrath, Jamie Chriqui, Jean O'Connor, Curtis J. Vanderwaal, Karen Mattson

Faculty Publications

Domestic production of methamphetamine in small toxic labs (STLs) results in significant community safety and health consequences. This paper examines the effects of state-level policies implemented in the middle of the last decade in reaction to a rapid increase in STL labs. These policies focused on controlling access to the methamphetamine precursor chemicals ephedrine and pseudoephedrine and the relationship of such policies with actual STL seizure rates. Data include (a) primary legal research on state laws/regulations in all 50 states in effect as of October 1, 2005; and (b) STL seizure counts for 2004–2006. Results from random effects cross-sectional time-series …

Discrimination, Perceived Social Inequity, And Mental Health Among Rural-To-Urban Migrants In China, Danhua Li, Xiaoming Li, Bo Wang, Yan Hong, Xiaoyi Fang, Xiong Qin, Bonita Stanton

Faculty Publications

Status-based discrimination and inequity have been associated with the process of migration, especially with economics-driven internal migration. However, their association with mental health among economy-driven internal migrants in developing countries is rarely assessed. This study examines discriminatory experiences and perceived social inequity in relation to mental health status among rural-to-urban migrants in China. Cross-sectional data were collected from 1,006 rural-to-urban migrants in 2004-2005 in Beijing, China. Participants reported their perceptions and experiences of being discriminated in daily life in urban destination and perceived social inequity. Mental health was measured using the symptom checklist-90 (SCL-90). Multivariate analyses using general linear model …

Do Physical Activity Facilities Near Schools Affect Physical Activity In High School Girls?, Jennifer L. Trilk, Dianne S. Ward, Marsha Dowda, Karin A. Pfeiffer, Dwayne E. Porter, James Hibbert, Russell R. Pate

Faculty Publications

Objective - To investigate associations between the number of physical activity facilities within walking distance of school and physical activity behavior in 12^th grade girls during after-school hours.

Methods - Girls (N=1394) from 22 schools completed a self-report to determine physical activity after 3:00 pm. The number of physical activity facilities within a 0.75-mile buffer of the school was counted with a Geographic Information System. Associations between the number of facilities and girls' physical activity were examined using linear mixed-model analysis of variance.

Results - Overall, girls who attended schools with ≥ 5 facilities within the buffer reported more …

Behavioral Contexts, Food-Choice Coping Strategies, And Dietary Quality Of A Multiethnic Sample Of Employed Parents, Christine E. Blake, Elaine Wethington, Tracy J. Farrell, Carole A. Bisogni, Carol M. Devine

Faculty Publications

Employed parents' work and family conditions provide behavioral contexts for their food choices. Relationships between employed parents' food-choice coping strategies, behavioral contexts, and dietary quality were evaluated. Data on work and family conditions, sociodemographic characteristics, eating behavior, and dietary intake from two 24-hour dietary recalls were collected in a random sample cross-sectional pilot telephone survey in the fall of 2006. Black, white, and Latino employed mothers (n=25) and fathers (n=25) were recruited from a low/moderate income urban area in upstate New York. Hierarchical cluster analysis (Ward's method) identified three clusters of parents differing in use of food-choice coping strategies (ie, …

Circadian Rhythm Of Cortisol And Neighborhood Characteristics In A Population-Based Sample: The Multi-Ethnic Study Of Atherosclerosis, D. Phuong Do, Ana V. Diez Roux, Anjum Hajat, Amy Auchincloss, Sharon Merkin, Nalini Ranjit, Steven Shea, Teresa Seeman

Faculty Publications

Although stress is often hypothesized to contribute to the effects of neighborhoods on health, very few studies have investigated associations of neighborhood characteristics with stress biomarkers. This study helps address the gap in the literature by examining whether neighborhood characteristics are associated with cortisol profiles. Analyses were based on data from the Multi-Ethnic Study of Atherosclerosis Stress study which collected multiple measures of salivary cortisol over three days on a population based sample of approximately 800 adults. Multilevel models with splines were used to examine associations of cortisol with neighborhood poverty, violence, disorder, and social cohesion. Neighborhood violence was significantly …

Validation Of The Actical Activity Monitor In Middle-Aged And Older Adults, Steven P. Hooker, Anna Feeney, Brent E. Hutto, Karin A. Pfeiffer, Kerry Mciver, Daniel P. Heil, John E. Vena, Michael J. Lamonte, Steven N. Blair

Faculty Publications

Purpose: This study was designed to validate the Actical activity monitor in middle-aged and older adults of varying body composition to develop accelerometer thresholds to distinguish between light and moderate intensity physical activity (PA).

Methods: Nonobese 45 to 64 yr (N = 29), obese 45 to 64 yr (N = 21), and ≥65 yr (N = 23; varying body composition) participants completed laboratory-based sitting, household, and locomotive activities while wearing an Actical monitor and a portable metabolic measurement system. Non-linear regression analysis was used to identify activity count (AC) cut-points to differentiate between light intensity (<3 METs) and moderate intensity (≥3 METs) PA.

Results: Using group-specific algorithms, …

A Geographic Information Assessment Of Exposure To A Toxic Waste Site And Development Of Systemic Lupus Erythematosus (Sle): Findings From The Buffalo Lupus Project, Edith M. Williams, Robert Watkins, Judith Anderson, Laurene Tumiel-Berhalter

Faculty Publications

The Buffalo Lupus Project was a community-based participatory research partnership formed to address the relationship between an identified hazardous waste site and high rates of lupus and other autoimmune diseases in the surrounding community. Most cases identified began experiencing symptoms and were diagnosed in the periods when the site was inactive. Trends suggest that the impact of the site was more likely due to chronic exposure to waste rather than it being an acute trigger.

Consumption Of Single Cigarettes And Quitting Behavior: A Longitudinal Analysis Of Mexican Smokers, James F. Thrasher, Victor Villalobos, Joaquin Barnoya, Raul Sansores, Richard J. O'Connor

Faculty Publications

Background: Previous cross-sectional research has suggested single cigarettes could either promote or inhibit consumption. The present study aimed to assess the effects of single cigarette availability and consumption on downstream quit behavior.

Methods: We analyzed population-based, longitudinal data from adult smokers who participated in the 2008 and 2010 administrations of the International Tobacco Control Policy Evaluation Survey in Mexico.

Results: At baseline, 30% of smokers saw single cigarettes for sale on a daily basis, 17% bought singles at their last purchase, and 7% bought singles daily. Smokers who most frequently purchased singles, both in general and specifically to control their …

Consumption Of Single Cigarettes And Quitting Behavior: A Longitudinal Analysis Of Mexican Smokers, Jim Thrasher, Victor Villalobos, Joaquin Barnoya, Raul Sansores, Richard O’Connor

Faculty Publications

Background: Previous cross-sectional research has suggested single cigarettes could either promote or inhibit consumption. The present study aimed to assess the effects of single cigarette availability and consumption on downstream quit behavior.

Methods: We analyzed population-based, longitudinal data from adult smokers who participated in the 2008 and 2010 administrations of the International Tobacco Control Policy Evaluation Survey in Mexico.

Results: At baseline, 30% of smokers saw single cigarettes for sale on a daily basis, 17% bought singles at their last purchase, and 7% bought singles daily. Smokers who most frequently purchased singles, both in general and specifically to control their …

Consumption Of Single Cigarettes And Quitting Behavior: A Longitudinal Analysis Of Mexican Smokers, Jim Thrasher, Victor Villalobos, Joaquin Barnoya, Raul Sansores, Richard O'Connor

Faculty Publications

Background: Previous cross-sectional research has suggested single cigarettes could either promote or inhibit consumption. The present study aimed to assess the effects of single cigarette availability and consumption on downstream quit behavior.

Methods: We analyzed population-based, longitudinal data from adult smokers who participated in the 2008 and 2010 administrations of the International Tobacco Control Policy Evaluation Survey in Mexico.

Results: At baseline, 30% of smokers saw single cigarettes for sale on a daily basis, 17% bought singles at their last purchase, and 7% bought singles daily. Smokers who most frequently purchased singles, both in general and specifically to control their …

Using A Technology-Based Intervention To Promote Weight Loss In Sedentary Overweight Or Obese Adults: A Randomized Controlled Trial Study Design, Vaughn W. Barry, Amanda C. Mcclain, Sara L. Shuger, Xuemei Sui, James W. Hardin, Gregory A. Hand, Sarah Wilcox, Steven N. Blair

Faculty Publications

Purpose: The SenseWear^TM Armband is an activity monitor developed to improve lifestyle self-monitoring. Currently, few studies assess electronic self-monitoring and weight loss with a lifestyle intervention program. To our knowledge, only one study has used the SenseWear Armband in combination with a lifestyle intervention to improve weight loss, and no studies have evaluated whether a self-monitoring intervention based solely on the armband can promote weight loss. Consequently, the aims of the study were to assess weight loss from electronic self-monitoring, to compare these values to the lifestyle intervention and standard care groups, and to compare weight loss with lifestyle …

Effects Of Androgen Receptor And Androgen On Gene Expression In Prostate Stromal Fibroblasts And Paracrine Signaling To Prostate Cancer Cells, Matthew J. Tanner, R. Charles Welliver, Mengqian Chen, Michael Shtutman, Alejandro Godoy, Gary Smith, Badar M. Mian, Ralph Buttyan

Faculty Publications

The androgen receptor (AR) is expressed in a subset of prostate stromal cells and functional stromal cell AR is required for normal prostate developmental and influences the growth of prostate tumors. Although we are broadly aware of the specifics of the genomic actions of AR in prostate cancer cells, relatively little is known regarding the gene targets of functional AR in prostate stromal cells. Here, we describe a novel human prostate stromal cell model that enabled us to study the effects of AR on gene expression in these cells. The model involves a genetically manipulated variant of immortalized human WPMY-1 …

Examining The Role Of Churches In Adolescent Girls' Physical Activity, Karin A. Pfeiffer, Natalie Colabianchi, Marsha Dowda, Dwayne E. Porter, James Hibbert, Russell R. Pate

Faculty Publications

Background: In adults, associations between church attendance and positive health behaviors exist; however, similar evidence among children and youth is lacking. The purposes of this investigation were to examine the associations between physical activity (PA) and church attendance, PA and use of church as a PA facility, and PA and proximity to churches among those who use church as a PA facility (while addressing racial and geographic differences). Methods: High school girls (N=915, age=17.7 ± 0.6 years, 56% African American) completed the 3-Day Physical Activity Recall and surveys including demographics and use of PA facilities. Geographic Information Systems data were …

Education And Levels Of Salivary Cortisol Over The Day In Us Adults, Jennifer B. Dowd, Nalini Ranjit, D. Phuong Do, Elizabeth A. Young, James S. House, George A. Kaplan

Faculty Publications

Background - Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is hypothesized to be an important pathway linking socioeconomic position and chronic disease.

Purpose - This paper tests the association between education and the diurnal rhythm of salivary control.

Methods - Up to 8 measures of cortisol (mean of 5.38 per respondent) over two days were obtained from 311 respondents aged 18-70, drawn from 2001-2002 Chicago Community Adult Health Study. Multi-level models with linear splines were used to estimate waking level, rates of cortisol decline, and area-under-the-curve over the day, by categories of education.

Results - Lower education (0-11 years) was associated …

Cardiorespiratory Fitness And Risk Of Prostate Cancer: Findings From The Aerobics Center Longitudinal Study, Wonwoo Byun, Xuemei Sui, James R. Hébert, Timothy S. Church, I-Min Lee, Charles E. Matthews, Steven N. Blair

Faculty Publications

Objective - To examine the association between cardiorespiratory (CRF) and risk of incident prostate cancer (PrCA).

Methods - Participants were 19,042 male subjects in the Aerobics Center Longitudinal Study (ACLS), ages 20 to 82 years, who received a baseline medical examination including a maximal treadmill exercise test between 1976 and 2003. CRF levels were defined as low (lowest 20%), moderate (middle 40%), and high (upper 40%) according to age-specific distribution of treadmill duration from the overall ACLS population. PrCA was assessed from responses to mail-back health surveys during 1982 to 2004. Cox proportional hazards regression models, adjusted for potential confounders, …

Who Tests, Who Doesn't, And Why? Uptake Of Mobile Hiv Counseling And Testing In The Kilimanjaro Region Of Tanzania, Jan Ostermann, Elizabeth A. Reddy, Meghan M. Shorter, Charles Muiruri, Antipas Mtalo, Dafrosa K. Itemba, Bernard Njau, John A. Bartlett, John A. Crump, Nathan M. Thielman

Faculty Publications

Background: Optimally, expanded HIV testing programs should reduce barriers to testing while attracting new and highrisk testers. We assessed barriers to testing and HIV risk among clients participating in mobile voluntary counseling and testing (MVCT) campaigns in four rural villages in the Kilimanjaro Region of Tanzania.

Methods: Between December 2007 and April 2008, 878 MVCT participants and 506 randomly selected community residents who did not access MVCT were surveyed. Gender-specific logistic regression models were used to describe differences in socioeconomic characteristics, HIV exposure risk, testing histories, HIV related stigma, and attitudes toward testing between MVCT participants and community residents who …

Changes In Cvd Risk Factors In The Activity Counseling Trial, Meghan Baruth, Sarah Wilcox, James F. Sallis, Abby C. King, Bess H. Marcus, Steven N. Blair

Faculty Publications

Primary care facilities may be a natural setting for delivering interventions that focus on behaviors that improve cardiovascular disease (CVD) risk factors. The purpose of this study was to examine the 24-month effects of the Activity Counseling Trial (ACT) on CVD risk factors, to examine whether changes in CVD risk factors differed according to baseline risk factor status, and to examine whether changes in fitness were associated with changes in CVD risk factors. ACT was a 24-month multicenter randomized controlled trial to increase physical activity. Participants were 874 inactive men and women aged 35-74 years. Participants were randomly assigned to …

Child Work And Labour Among Orphaned And Abandoned Children In Five Low And Middle Income Countries, Rachel Whetten, Lynne Messer, Jan Ostermann, Kathryn Whetten, Brian Wells Pence, Megan Buckner, Nathan Thielman, Karen O’Donnell, The Positive Outcomes For Orphans (Pofo) Research Team

Faculty Publications

Background

The care and protection of the estimated 143,000,000 orphaned and abandoned children (OAC) worldwide is of great importance to global policy makers and child service providers in low and middle income countries (LMICs), yet little is known about rates of child labour among OAC, what child and caregiver characteristics predict child engagement in work and labour, or when such work infers with schooling. This study examines rates and correlates of child labour among OAC and associations of child labour with schooling in a cohort of OAC in 5 LMICs.

Methods

The Positive Outcomes for Orphans (POFO) study employed a …

Integrating A Professional Apprenticeship Model With Clinical Simulation For Psychiatric Nursing Students, M. C. Crider, Susan Mcniesh

Faculty Publications

In this article, we present a theory-based application of clinical simulation in psychiatric-mental health nursing education. As described by Benner, Sutphen, Leonard, and Day, a three-pronged apprenticeship that integrates intellectual, practical, and ethical aspects of the professional role is critical in the development of practical reasoning in nursing education and training. Clinical encounters are often fraught with ambiguity and uncertainty. Therefore, educating for a practice discipline requires experiential and situated learning. Using the three-pronged experiential model in simulated psychiatric-mental health nursing practice supports the development of critical nursing skills, ethics, and theoretical concepts. A clinical scenario is presented that demonstrates …

The Lived Experience Of Students In An Accelerated Nursing Program: Intersecting Factors That Influence Experiential Learning, Susan Mcniesh

Faculty Publications

The goal of this interpretive research study was to articulate the lived experience of students in an accelerated master’s of nursing entry program learning the practice of nursing within a clinical setting. Specific questions included: How did previous life experiences, education, and career choices influence the experience of second-degree students? What were the potential effects on learning of condensing and accelerating the curriculum as is requisite in second-degree programs? Data from small group and individual interviews were collected and analyzed using interpretive phenomenological methods. Akin to the experience of tourists or new immigrants, students were confronted with new physical demands, …