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A Mandatory Single Blastocyst Transfer Policy With Educational Campaign In A United States Ivf Program Reduces Multiple Gestation Rates Without Sacrificing Pregnancy Rates, Ginny Ryan, Amy Sparks, C. Sipe, Craig Syrop, A. Dokras, Bradley Van Voorhis Jun 2013

A Mandatory Single Blastocyst Transfer Policy With Educational Campaign In A United States Ivf Program Reduces Multiple Gestation Rates Without Sacrificing Pregnancy Rates, Ginny Ryan, Amy Sparks, C. Sipe, Craig Syrop, A. Dokras, Bradley Van Voorhis

Amy E.T. Sparks

OBJECTIVE: To reduce the twin rate in our IVF program. DESIGN: A prospective educational study of infertile couples; a retrospective review of IVF outcomes before vs. after mandatory single embryo transfer (mSBT) policy change. SETTING: University-based infertility center. PATIENT(S): One hundred ten of 120 consecutive new infertile couples completed the educational study. Outcomes of all embryo transfers (n = 693) performed 17 months before and 17 months after mSBT were evaluated. INTERVENTION(S): A 1-page educational summary of comparative risks of twins vs. singletons to maternal and child health. MAIN OUTCOME MEASURE(S): Knowledge of twin risks and desired number of embryos …


Identification Of Apolipoprotein A1 In The Human Embryonic Secretome, Lindsay Mains, Lane Christenson, Baoli Yang, Amy Sparks, Satya Mathur, Bradley Van Voorhis Jun 2013

Identification Of Apolipoprotein A1 In The Human Embryonic Secretome, Lindsay Mains, Lane Christenson, Baoli Yang, Amy Sparks, Satya Mathur, Bradley Van Voorhis

Amy E.T. Sparks

No abstract provided.


Semen Analysis. What Tests Are Clinically Useful, Bradley Van Voorhis, Amy Sparks Jun 2013

Semen Analysis. What Tests Are Clinically Useful, Bradley Van Voorhis, Amy Sparks

Amy E.T. Sparks

No abstract provided.


The Risk Of Low Birth Weight After Intrauterine Insemination (Iui), G. Ryan, C. Olson, Amy Sparks, Bradley Van Voorhis Jun 2013

The Risk Of Low Birth Weight After Intrauterine Insemination (Iui), G. Ryan, C. Olson, Amy Sparks, Bradley Van Voorhis

Amy E.T. Sparks

No abstract provided.


Supernumerary Minute Ring Chromosome 14 In A Man With Primary Infertility And Left Varicocele, B. Stahl, S. Patil, Craig Syrop, Amy Sparks, M. Wald Jun 2013

Supernumerary Minute Ring Chromosome 14 In A Man With Primary Infertility And Left Varicocele, B. Stahl, S. Patil, Craig Syrop, Amy Sparks, M. Wald

Amy E.T. Sparks

OBJECTIVE: To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. DESIGN: Case report. SETTING: Urologic infertility clinic in a university hospital. PATIENT(S): Male patient presenting with primary infertility. INTERVENTION(S): Karyotyping, genetic counseling, and microsurgical left varicocelectomy. MAIN OUTCOME MEASURE(S): Sperm concentration and motility, chromosomal number and structure. RESULT(S): Fluorescence in situ hybridization revealing SMRC 14. Sperm concentration and motility improved after left varicocele repair. CONCLUSION(S): A karyotype should be included in the evaluation of severe oligospermia. Although SMRC 14 may be associated with fertility problems, repair of …


Educational Campaign Improves Knowledge Of Twin Risks In Ivf Patients But May Not Impact Number Of Embryos Transferred, G. Ryan, Amy Sparks, C. Sipe, A. Dokras, Craig Syrop, Bradley Van Voorhis Jun 2013

Educational Campaign Improves Knowledge Of Twin Risks In Ivf Patients But May Not Impact Number Of Embryos Transferred, G. Ryan, Amy Sparks, C. Sipe, A. Dokras, Craig Syrop, Bradley Van Voorhis

Amy E.T. Sparks

No abstract provided.


Establishing Of A Pay For Performance Program For In Vitro Fertilization (Ivf), E. Rosenbluth, Amy Sparks, Bradley Van Voorhis Jun 2013

Establishing Of A Pay For Performance Program For In Vitro Fertilization (Ivf), E. Rosenbluth, Amy Sparks, Bradley Van Voorhis

Amy E.T. Sparks

No abstract provided.


Clinical Predictors Of Human Blastocyst Formation And Pregnancy After Extended Embryo Culture And Transfer, M. Thomas, Amy Sparks, Ginny Ryan, Bradley Van Voorhis Jun 2013

Clinical Predictors Of Human Blastocyst Formation And Pregnancy After Extended Embryo Culture And Transfer, M. Thomas, Amy Sparks, Ginny Ryan, Bradley Van Voorhis

Amy E.T. Sparks

OBJECTIVE: To determine the clinical factors associated with blastocyst development and pregnancy. DESIGN: Evaluation of a prospectively collected IVF database. SETTING: An academic IVF practice. PATIENT(S): Couples (n = 529) undergoing their first IVF cycle who qualified for extended embryo culture (more than six zygotes) over the past 5 years. INTERVENTION(S): Seven or eight zygotes were cultured for 5 days, assessed for quality, and then transferred with excess zygotes cryopreserved at the pronuclear stage. MAIN OUTCOME MEASURE(S): Clinical predictors of blastocyst development and pregnancy. RESULT(S): The mean blastocyst development rate was 49.8%, with a median number of total and good-quality …


Novel Us Mandatory Single Blastocyst Policy Decreases Multiple Gestation Rates Without Sacrificing Pregnancy Rates, Bradley Van Voorhis, Amy Sparks, G. Ryan, C. Sipe, A. Dokras, W. Davis, Craig Syrop Jun 2013

Novel Us Mandatory Single Blastocyst Policy Decreases Multiple Gestation Rates Without Sacrificing Pregnancy Rates, Bradley Van Voorhis, Amy Sparks, G. Ryan, C. Sipe, A. Dokras, W. Davis, Craig Syrop

Amy E.T. Sparks

No abstract provided.


Hyperbaric Oxygen Therapy And In Vitro Fertilization - A Pilot Study., Bradley Van Voorhis, J. Greensmith, A. Dokras, M. Maifeld, Amy Sparks, Craig Syrop Jun 2013

Hyperbaric Oxygen Therapy And In Vitro Fertilization - A Pilot Study., Bradley Van Voorhis, J. Greensmith, A. Dokras, M. Maifeld, Amy Sparks, Craig Syrop

Amy E.T. Sparks

No abstract provided.


Predictive Value Of Strict Criteria Sperm Morphology For Intrauterine Insemination Outcomes., Amy Sparks, Bradley Van Voorhis, L. Holz, A. Dokras, W. Davis, Craig Syrop Jun 2013

Predictive Value Of Strict Criteria Sperm Morphology For Intrauterine Insemination Outcomes., Amy Sparks, Bradley Van Voorhis, L. Holz, A. Dokras, W. Davis, Craig Syrop

Amy E.T. Sparks

No abstract provided.


Semen Analysis. What Tests Are Clinically Useful?, Bradley Van Voorhis, Amy Sparks Jun 2013

Semen Analysis. What Tests Are Clinically Useful?, Bradley Van Voorhis, Amy Sparks

Amy E.T. Sparks

No abstract provided.


Assisted Reproduction And Risk Of Birth Defects., C. Olson, Craig Syrop, A. Dokras, Amy Sparks, W. Davis, Bradley Van Voorhis Jun 2013

Assisted Reproduction And Risk Of Birth Defects., C. Olson, Craig Syrop, A. Dokras, Amy Sparks, W. Davis, Bradley Van Voorhis

Amy E.T. Sparks

No abstract provided.


Ultrasound-Guided Aspiration Of Hydrosalpinges Is Associated With Improved Pregnancy And Implantation Rates After In-Vitro Fertilization Cycles, Bradley Van Voorhis, Amy Sparks, Craig Syrop, D. Stovall Jun 2013

Ultrasound-Guided Aspiration Of Hydrosalpinges Is Associated With Improved Pregnancy And Implantation Rates After In-Vitro Fertilization Cycles, Bradley Van Voorhis, Amy Sparks, Craig Syrop, D. Stovall

Amy E.T. Sparks

No abstract provided.


Clinical Predictors Of Human Blastocyst Formation In Vitro., M. Thomas, C. Sipe, Amy Sparks, A. Dokras, G. Ryan, Bradley Van Voorhis Jun 2013

Clinical Predictors Of Human Blastocyst Formation In Vitro., M. Thomas, C. Sipe, Amy Sparks, A. Dokras, G. Ryan, Bradley Van Voorhis

Amy E.T. Sparks

No abstract provided.


An Evaluation Of The Effect Of Anesthetic Technique On Reproductive Success After Laparoscopic Pronuclear Stage Transfer - Propofol Nitrous-Oxide Versus Isoflurane Nitrous-Oxide, R. Vincent, Craig Syrop, Bradley Van Voorhis, D. Chestnut, Amy Sparks, J. Mcgrath, W. Choi, J. Bates, D. Penning Jun 2013

An Evaluation Of The Effect Of Anesthetic Technique On Reproductive Success After Laparoscopic Pronuclear Stage Transfer - Propofol Nitrous-Oxide Versus Isoflurane Nitrous-Oxide, R. Vincent, Craig Syrop, Bradley Van Voorhis, D. Chestnut, Amy Sparks, J. Mcgrath, W. Choi, J. Bates, D. Penning

Amy E.T. Sparks

No abstract provided.


Establishment Of A Successful Donor Embryo Program: Medical, Ethical, And Policy Issues, Bradley Van Voorhis, D. Grinstead, Amy Sparks, J. Gerard, R. Weir Jun 2013

Establishment Of A Successful Donor Embryo Program: Medical, Ethical, And Policy Issues, Bradley Van Voorhis, D. Grinstead, Amy Sparks, J. Gerard, R. Weir

Amy E.T. Sparks

No abstract provided.


Microrna Expression In The Human Blastocyst, E. Rosenbluth, D. Shelton, Amy Sparks, Eric Devor, L. Christenson, Bradley Van Voorhis Jun 2013

Microrna Expression In The Human Blastocyst, E. Rosenbluth, D. Shelton, Amy Sparks, Eric Devor, L. Christenson, Bradley Van Voorhis

Amy E.T. Sparks

OBJECTIVE: To determine the most highly expressed microRNAs (miRNAs) in human blastocysts and to compare miRNAs in euploid versus aneuploid embryos and in male versus female embryos. DESIGN: Experimental study of human embryos: 14 blastocysts (four male, five female, and five aneuploid) were evaluated for miRNA expression with the use of an array-based quantitative real-time polymerase chain reaction (qPCR). Highly expressed and differentially expressed miRNAs were confirmed with the use of qPCR in an expanded set of 27 blastocysts (seven male, eleven female, and nine aneuploid). SETTING: Academic IVF program. PATIENT(S): Thirteen couples donated 91 cryopreserved embryos for this study. …


Five-Year Experience With A Single Embryo Transfer (Set) Policy, J. Kresowik, B. Stegmann, Amy Sparks, G. Ryan, Bradley Van Voorhis Jun 2013

Five-Year Experience With A Single Embryo Transfer (Set) Policy, J. Kresowik, B. Stegmann, Amy Sparks, G. Ryan, Bradley Van Voorhis

Amy E.T. Sparks

No abstract provided.


Five-Years Of A Mandatory Single-Embryo Transfer (Mset) Policy Dramatically Reduces Twinning Rate Without Lowering Pregnancy Rates, J. Kresowik, B. Stegmann, Amy Sparks, Ginny Ryan, Bradley Van Voorhis Jun 2013

Five-Years Of A Mandatory Single-Embryo Transfer (Mset) Policy Dramatically Reduces Twinning Rate Without Lowering Pregnancy Rates, J. Kresowik, B. Stegmann, Amy Sparks, Ginny Ryan, Bradley Van Voorhis

Amy E.T. Sparks

OBJECTIVE: To report the outcomes of a program policy instituted in 2004 mandating single-embryo transfer (mSET) for all women aged <38 >years, with at least seven zygotes, no prior failed fresh cycle at our center, and at least one good-quality blastocyst. DESIGN: Retrospective cohort study. SETTING: Academic medical center. PATIENT(S): All women 1, 1999, to May 31, 2004 (before mSET) and from June 1, 2004, to May 31, 2009 (after mSET). INTERVENTION(S): mSET policy implementation. MAIN OUTCOME MEASURE(S): Live-birth rate, multiple pregnancy rate, clinical volume, and outcomes of all mSET fresh IVF transfers were analyzed. RESULT(S): Clinical volume was unchanged between …


The Effects Of Smoking On Ovarian Function And Fertility During Assisted Reproduction Cycles, B. J. Vanvoorhis, J. D. Dawson, D. W. Stovall, Amy Sparks, Craig Syrop Jun 2013

The Effects Of Smoking On Ovarian Function And Fertility During Assisted Reproduction Cycles, B. J. Vanvoorhis, J. D. Dawson, D. W. Stovall, Amy Sparks, Craig Syrop

Amy E.T. Sparks

No abstract provided.


In Vitro Fertilization Patients Support A Single Blastocyst Transfer Policy, S. Martini, Bradley Van Voorhis, B. Stegmann, Amy Sparks, T. Shochet, M. Zimmerman, Ginny Ryan Jun 2013

In Vitro Fertilization Patients Support A Single Blastocyst Transfer Policy, S. Martini, Bradley Van Voorhis, B. Stegmann, Amy Sparks, T. Shochet, M. Zimmerman, Ginny Ryan

Amy E.T. Sparks

OBJECTIVE: To determine whether patients support a mandatory single blastocyst transfer (mSBT) policy in IVF. DESIGN: Prospective survey study. SETTING: Academic hospital-based infertility center. PATIENT(S): Two hundred sixty-two female patients presenting for fresh or cryopreserved/thawed ET after IVF. INTERVENTION(S): Internet-based in-clinic survey after ET. Follow-up at-home survey after pregnancy test results. MAIN OUTCOME MEASURE(S): Patient support for an mSBT policy and attitudes regarding patient input into IVF treatment. Logistic regression analyses tested associations among main outcome measures, patient characteristics, and treatment results. RESULT(S): Ninety-four percent of patients endorsed support for our mSBT policy; 95% and 87% felt they had the …


Efficacy And Cost-Effectiveness Of Gonadotropin/Intrauterine Insemination Therapy With And Without Oral Induction Agents., G. Ryan, V. Moss, W. Davis, Amy Sparks, A. Dokras, Bradley Van Voorhis Jun 2013

Efficacy And Cost-Effectiveness Of Gonadotropin/Intrauterine Insemination Therapy With And Without Oral Induction Agents., G. Ryan, V. Moss, W. Davis, Amy Sparks, A. Dokras, Bradley Van Voorhis

Amy E.T. Sparks

No abstract provided.


The Efficacy And Cost Effectiveness Of Embryo Cryopreservation Compared With Other Assisted Reproductive Techniques, Bradley Van Voorhis, Craig Syrop, B. Allen, Amy Sparks, D. Stovall Jun 2013

The Efficacy And Cost Effectiveness Of Embryo Cryopreservation Compared With Other Assisted Reproductive Techniques, Bradley Van Voorhis, Craig Syrop, B. Allen, Amy Sparks, D. Stovall

Amy E.T. Sparks

OBJECTIVE: To evaluate the efficacy and cost effectiveness of embryo cryopreservation compared with other assisted reproductive techniques (ARTs). DESIGN: Retrospective review of medical records and health care costs. SETTING: Tertiary care academic medical school ART program. PATIENTS: For determination of the efficacy of cryopreserved ET, we analyzed 610 patients undergoing the first 1,000 oocyte retrievals in our program. For determination of cost effectiveness, we analyzed the costs associated with 334 initiated ART cycles in 1992. MAIN OUTCOME MEASURES: The ongoing pregnancy rate (PR) per initiated cycle and per oocyte retrieval. The medical costs associated with each procedure. RESULTS: The transfer …


Uterine Leiomyomas Reduce The Efficacy Of Assisted Reproduction Cycles: Results Of A Matched Follow-Up Study, D. Stovall, S. Parrish, Bradley Van Voorhis, S. Hahn, Amy Sparks, Craig Syrop Jun 2013

Uterine Leiomyomas Reduce The Efficacy Of Assisted Reproduction Cycles: Results Of A Matched Follow-Up Study, D. Stovall, S. Parrish, Bradley Van Voorhis, S. Hahn, Amy Sparks, Craig Syrop

Amy E.T. Sparks

No abstract provided.


Microsurgical Epididymal Sperm Aspiration, J. Sandlow, J. Donovan, Amy Sparks, Craig Syrop, Bradley Van Voorhis, D. Stovall Jun 2013

Microsurgical Epididymal Sperm Aspiration, J. Sandlow, J. Donovan, Amy Sparks, Craig Syrop, Bradley Van Voorhis, D. Stovall

Amy E.T. Sparks

No abstract provided.


What Do Consistently High-Performing In Vitro Fertilization Programs In The Us Do?, Bradley Van Voorhis, Mika Thomas, Eric Surrey, Amy Sparks Jun 2013

What Do Consistently High-Performing In Vitro Fertilization Programs In The Us Do?, Bradley Van Voorhis, Mika Thomas, Eric Surrey, Amy Sparks

Amy E.T. Sparks

No abstract provided.


Obstetric Outcomes After In Vitro Fertilization In Obese And Morbidly Obese Women., Anuja Dokras, Lindsey Baredziak, Jill Blaine, Craig Syrop, Bradley Van Voorhis, Amy Sparks Jun 2013

Obstetric Outcomes After In Vitro Fertilization In Obese And Morbidly Obese Women., Anuja Dokras, Lindsey Baredziak, Jill Blaine, Craig Syrop, Bradley Van Voorhis, Amy Sparks

Amy E.T. Sparks

OBJECTIVE: In addition to numerous health detriments caused by obesity, fertility and pregnancy success may also be compromised. The aims of this study were to compare the effects of obesity and morbid obesity on in vitro fertilization (IVF) outcomes. We also investigated the effects of obesity on obstetric outcomes after IVF treatment. METHODS: Retrospective study of women less than 38 years of age during their first fresh IVF cycle (January 1995 to April 2005). RESULTS: A total of 1,293 women were included in the study, with 236 obese women (body mass index [BMI] = 30-39.9) and 79 morbidly obese women …