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Articles 871 - 900 of 2525
Full-Text Articles in Medicine and Health Sciences
The Role Of Ribosomal Protein S25 In Non-Canonical Translation Initiation, Beth Angela Walters
The Role Of Ribosomal Protein S25 In Non-Canonical Translation Initiation, Beth Angela Walters
All ETDs from UAB
Most messenger RNA (mRNA) are translated in a cap-dependent manner, requir-ing the recognition of a 5’ cap structure by a set of eukaryotic initiation factors (eIFs) in-cluding the 40S ribosomal subunit. The subunit scans the mRNA until the start codon is recognized, triggering the release of eIFs and recruitment of the 60S subunit. Cellular stress and viral infection down-regulate cap-dependent translation, therefore, cellular and viral messages rely on a cap-independent mechanism. One mechanism requires an inter-nal ribosome entry site (IRES). Viral IRESs were discovered over 25 years ago, with cellular IRESs to follow. The study of viral IRESs has brought …
Post-Transcriptional Regulation Of Autophagy By The 5’-3’ Mrna Decay Pathway In Saccharomyces Cerevisiae, Matthew Weaver
Post-Transcriptional Regulation Of Autophagy By The 5’-3’ Mrna Decay Pathway In Saccharomyces Cerevisiae, Matthew Weaver
All ETDs from UAB
The process of bulk degradation of cytoplasmic contents, called macroautophagy or simply autophagy, is a heavily conserved cellular process from yeast to humans. In yeast, it involves more than 30 different autophagy related genes (ATG) that coordinate the process of building a double membrane vesicle, called the autophagosome, that fuses with the vacuole to allow degradation and recycling of its contents. This process can also be selective, involving the recruitment of the autophagic machinery to specific organelles. In this work, we used RNA sequencing (RNA-seq) to identify a subset of ATG genes that are heavily upregulated in response to nitrogen …
The G Protein-Coupled Estrogen Receptor (Gper) Mediates Estrogen-Induced Regulation Of Heart Rate By Modulating Thyroid Hormone Levels In Zebrafish Embryos, Shannon Nicole Romano
The G Protein-Coupled Estrogen Receptor (Gper) Mediates Estrogen-Induced Regulation Of Heart Rate By Modulating Thyroid Hormone Levels In Zebrafish Embryos, Shannon Nicole Romano
All ETDs from UAB
Estrogens regulate cell signaling and gene expression by binding to nuclear estrogen receptors (ERs) alpha and beta (ERα, ERβ), ligand-dependent transcription factors. Estrogens also activate the G protein-coupled estrogen receptor (GPER), however the function of GPER in vivo is less well understood. In the cardiovascular system, estrogens regulate vessel pressure and exert cardioprotective effects on the vasculature. However, whether estrogens act directly to modulate heart function, and the mechanism by which this occurs is not well understood. Therefore, the overall goals of this dissertation were to (1) determine if estrogen receptor ligands modulate heart rate and to (2) determine the …
Relationship Between Walking Speed And Kinematic Trajectory Complexity In People With Poststroke Hemiparesis, Deanna Delayne Rumble
Relationship Between Walking Speed And Kinematic Trajectory Complexity In People With Poststroke Hemiparesis, Deanna Delayne Rumble
All ETDs from UAB
Individuals with chronic poststroke hemiparesis (PS) exhibit increased variability in spatiotemporal kinematic variables related to endpoint control during walking. For nonimpaired individuals, walking faster or slower than a preferred walking speed, results in less consistent stepping behavior. In three studies I investigated variability in swing phase foot trajectory area on a step-by-step basis (SBS-FTA) in nonimpaired individuals and people with PS. The primary aims of these studies were to 1) validate SBS-FTA in nonimpaired individuals, 2) observe if there was a difference in SBS-FTA variability between nonimpaired individual’s limb, the PS paretic, and nonparetic limbs, and across a wide range …
Beam Study In Orthodontic Patients, Benjamin Samuelson
Beam Study In Orthodontic Patients, Benjamin Samuelson
All ETDs from UAB
Introduction: One of the most challenging tasks of the orthodontic team is to motivate patients to maintain proper oral hygiene. In order to improve compliance, clinicians are utilizing mobile applications. The goals of this study are to determine the efficacy of an application-based approach in increasing orthodontic patient’s oral hygiene compliance, as well as measure the correlation between the reported compliance and clinical parameters of gingival health. Materials & Methods: The Beam® toothbrush and its application software (app) were selected for evaluation. Three prospective groups of 15 patients undergoing routine orthodontic treatment were evaluated as part of this research protocol …
A Comparative Multiyear Assessment Of Care Utilization Between Existing And Newly Enrolled Medicaid Populations Within Washington State, Preston M. Simmons
A Comparative Multiyear Assessment Of Care Utilization Between Existing And Newly Enrolled Medicaid Populations Within Washington State, Preston M. Simmons
All ETDs from UAB
A COMPARATIVE MULTIYEAR ASSESSMENT OF CARE UTILIZATION BETWEEN EXISTING AND NEWLY ENROLLED MEDICAID POPULATIONS WITHIN WASHINGTON STATE ABSTRACT The study looks at 2012 through June of 2016 Medicaid data from the Washington State Health Care Authority, comparing claims utilization for newly enrolled patients each calendar year to continuously enrolled members. Mean number of emergency department, hospital, and ambulatory (office) claims per Medicaid member are compared to ascertain if they are the same or different between the groups. Differences in the mean number of ambulatory care sensitive conditions (ACSC) were additionally assessed between those continuously and newly enrolled. The results of …
The Relationship Of Lean Implementation And Patient Satisfaction (Hcahps) Scores In Acute Care Hospitals, Charles V. Hagood
The Relationship Of Lean Implementation And Patient Satisfaction (Hcahps) Scores In Acute Care Hospitals, Charles V. Hagood
All ETDs from UAB
THE RELATIONSHIP OF LEAN IMPLEMENTATION AND PATIENT SATISFACTION (HCAHPS) SCORES IN ACUTE CARE HOSPITALS CHARLES V. HAGOOD DOCTOR OF SCIENCE IN HEALTH SERVICES ADMINISTRATION ABSTRACT Background: The purpose of the study was to better understand the relationship of Lean implementation and patient satisfaction (HCAHPS) scores in acute care hospitals. Hospitals are under significant pressure to improve patient satisfaction, thus a number of hospitals are increasingly using Lean improvement methodologies to do so. However, the results that have been achieved are often reported as mixed at best and lack empirical proof, specifically the relationship of Lean methodologies and their impact on …
Ca2+-Independent Phospholipase A2 Beta-Derived Lipid Signals And Osteogenesis, William Hancock
Ca2+-Independent Phospholipase A2 Beta-Derived Lipid Signals And Osteogenesis, William Hancock
All ETDs from UAB
Bone modeling can be modulated by lipid signals and arachidonic acid (AA); its cyclo-oxygenase 2 (COX2) metabolite, prostaglandin E2 (PGE2), is an important mediator of optimal bone formation. Hydrolysis of AA from membrane glycerophospholipids is catalyzed by phospholipases A2 (PLA2s). We reported that mice deficient in the Ca2+-independent PLA2beta (iPLA2β), encoded by PLA2G6, have decreased bone formation, relative to wild type (WT) mouse bones. Here, we examined at the mechanistic and molecular levels the role of iPLA2β in bone formation using bone marrow stromal cells and calvarial osteoblasts from WT and iPLA2β-deficient mice and MC3T3-E1 osteoblast precursor cell line. Our …
The Use Of Web Computing To Solve Modern Data Problems In Science And Medicine, Alex M. Dussaq
The Use Of Web Computing To Solve Modern Data Problems In Science And Medicine, Alex M. Dussaq
All ETDs from UAB
Modern day research in science and medicine has become dominated by the ideas of 'Big Data'. Life science data have become progressively more complex and the rate at which it is generated continues to accelerate. This combination of complexity and genera- tion speed creates a multitude of informatics problems to solve. We believe that among the many issues facing modern data scientists, there exists a substantial subset that can only be satisfactorily solved utilizing web computing. Of these web specific issues, we have chosen to focus primarily on data storage and retrieval, data privacy, and data visualization. We present here …
A Delicate Balancing Act: Curing Humanized Mouse Models Of Cooley’S Anemia By Reducing The Globin Chain Imbalance, Suean D. Fontenard
A Delicate Balancing Act: Curing Humanized Mouse Models Of Cooley’S Anemia By Reducing The Globin Chain Imbalance, Suean D. Fontenard
All ETDs from UAB
Cooley’s Anemia (CA) is a hereditary disease which occurs when an individual inherits two null β-globin alleles. CA presents during the latter part of the first year of life due to the high levels of fetal hemoglobin (HbF) in the circulating red blood cells (RBCs) at birth. The absence of β-globin chains, to dimerize with α-globin chains in the newly formed bone marrow derived erythroblasts, results in premature destruction of the erythroid cells in the marrow and ineffective erythropoiesis. I hypothesized that increas-ing the amount of β-like globin chains for hemoglobin assembly in erythroblasts would lessen disease severity or even …
Phenotypic Characteristics And Dietary Treatment Of Pediatric Non-Alcoholic Fatty Liver Disease, Shima Dowla
Phenotypic Characteristics And Dietary Treatment Of Pediatric Non-Alcoholic Fatty Liver Disease, Shima Dowla
All ETDs from UAB
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder among children in the developed world and can progress to cirrhosis, hepatocellular carcinoma, and liver failure. Objectives: The primary objectives of this dissertation were to (1) review advances in the field of pediatric NAFLD, (2) describe the demographic, anthropometric and metabolic characteristics of children with NAFLD and evaluate whether differences existed based on ethnicity and diagnostic method, and (3) compare the effect of a carbohydrate restricted diet vs fat reduced diet on improvement in hepatic steatosis over an 8-week period among overweight and obese children diagnosed with NAFLD. …
A Tissue Engineering Approach To The Development Of A 3d Breast Carcinoma Surrogate, Kayla Goliwas
A Tissue Engineering Approach To The Development Of A 3d Breast Carcinoma Surrogate, Kayla Goliwas
All ETDs from UAB
Tumors are three dimensional tissues consisting of malignant cells and various stromal cell populations within a volume of extracellular matrix. These components form an intricate network that influences many facets of tumor biology. Paracrine interactions between tumor cells and the surrounding microenvironment can alter drug response and impact therapeutic efficacy in vivo, yet most current in vitro models do not accurately recapitulate the stromal microenvironment or associated dimensionality of human tumors. In vitro models that are more representative of the human tumor microenvironment, including a more recapitulative dimensionality and cellular composition, have broad utility in the evaluation of mechanisms driving …
Effect Of Parents’ Adhd Status, Parents’ Sleep Hygiene, And Child Sleep Hygiene On Sleep Of School-Aged Children With Adhd, Laura Gray
All ETDs from UAB
EFFECT OF PARENTS’ ADHD STATUS, PARENTS’ SLEEP HYGIENE, AND CHILD SLEEP HYGIENE ON SLEEP OF SCHOOL-AGED CHILDREN WITH ADHD LAURA GRAY NURSING ABSTRACT The purpose of this study was to determine effect sizes for the relationships between parents’ attention-deficit/hyperactivity disorder (ADHD) symptoms, parents’ sleep hygiene, and child sleep hygiene, and to determine effect sizes for the amount of variance in ADHD child sleep explained by parent ADHD symptoms, parent sleep hygiene, and child sleep hygiene. Children who have ADHD are more likely to have sleep problems than peers without ADHD. Sleep problems can exacerbate or even mimic ADHD symptoms. Consistent …
A Multilevel Perspective On Health Information Exchange, Claudia Guerrazzi
A Multilevel Perspective On Health Information Exchange, Claudia Guerrazzi
All ETDs from UAB
As the health care sector faces pressure to improve quality and contain costs, sharing information among the various care providers will become an essential practice among health care providers. Many countries are now adopting policies to foster Health Information Exchange (HIE), which is defined as the electronic transfer of data or information among health care organizations involved in the delivery of care. The literature about HIE reports contradictory evidence about the adoption and the use of HIE and more research is needed to understand this complex phenomenon. Specifically, HIE is a complex phenomenon that produces outcomes at different levels and …
Purification, Characterization, And Enzymatic Activity Of Human Cytosolic Sulfotransferase 1c4, Amber Lynn Guidry
Purification, Characterization, And Enzymatic Activity Of Human Cytosolic Sulfotransferase 1c4, Amber Lynn Guidry
All ETDs from UAB
Human cytosolic sulfotransferase 1C4 (hSULT1C4) is a dimeric Phase II drug-metabolizing enzyme primarily expressed in the developing fetus. SULTs facilitate the transfer of a hydrophilic sulfonate moiety from 3’-phosphoadenosine-5’-phosphosulfate (PAPS) onto an acceptor substrate altering the substrate’s biological activity and increasing the compound’s water solubility. While several of the hSULTs’ endogenous and xenobiotic substrates have been identified, the physiological function of hSULT1C4 remains unknown. The fetal expression of hSULT1C4 leads to the hypothesis that the function of this enzyme may be to regulate metabolic and hormonal signaling molecules, such as estrogenic compounds, that may be generated or consumed by the …
Development And Assessment Of Nonsense Suppression Therapies To Ameliorate Disease Progression In A Nonsense Mouse Model Of Mps I Hurler Syndrome, Gwendolyn G. Gunn
Development And Assessment Of Nonsense Suppression Therapies To Ameliorate Disease Progression In A Nonsense Mouse Model Of Mps I Hurler Syndrome, Gwendolyn G. Gunn
All ETDs from UAB
Nonsense mutations introduce a premature termination codon (PTC) into the open reading frame of an mRNA resulting in premature translation termination, loss of functional protein, and rapid degradation of the mutant mRNA. Approximately 11% of human genetic disorders are attributable to a nonsense mutation. Several small molecules have been identified as potential nonsense suppression compounds. These compounds increase the frequency of PTC recognition by near-cognate aminoacyl tRNAs resulting in PTC “readthrough” and restored protein production. Mucopolysaccharidosis type I-Hurler (MPS IH) is the severe form of the autosomal recessive lysosomal storage disorder caused by mutations in the iduronidase (IDUA) gene. 60-80% …
Phenomic And Metabolomic Analysis Of Chronological Aging In Saccharomyces Cerevisiae, Haley Albright
Phenomic And Metabolomic Analysis Of Chronological Aging In Saccharomyces Cerevisiae, Haley Albright
All ETDs from UAB
Systematic investigation of chronological lifespan (CLS) in the Saccharomyces cerevisiae yeast gene knockout and knockdown (YKO/KD) strains reveals genes, path-ways, and interactions of potential relevance for aging of all eukaryotic cell types. Growth curves obtained by quantitative high-throughput cell array phenotyping (Q-HTCP) of the entire YKO/KD strain collection provide comprehensive snapshots of the influence of each individual gene on CLS. Yeast CLS is also influenced by media com-position, auxotrophic background, and media buffering. We used Q-HTCP to analyze CLS of the YKO/KD libraries, focusing on the interaction between gene networks and media buffering, with respect to their influence on CLS. …
Reciprocal Regulation Of The Α2a Adrenergic Receptor And The Amyloid Precursor Protein, Mary Alana Gannon
Reciprocal Regulation Of The Α2a Adrenergic Receptor And The Amyloid Precursor Protein, Mary Alana Gannon
All ETDs from UAB
Through widespread efferent projections, the locus coeruleus-noradrenergic (LC-NA) system supplies the cerebral cortex with norepinephrine, a key modulator of cognition. Neurodegeneration of the LC is an early hallmark of Alzheimer’s disease (AD), but despite this profound neuronal loss, there are several studies that show that NE levels actually remain stable or even elevated, especially at early stages of the disease. This indicates that the overall integrity of the NA system, rather than a loss of NE, is likely contributing to AD pathogenesis. We previously showed that activation of the α2A adrenergic receptor (α2AAR) increases amyloidogenic processing of amyloid precursor protein …
Retention Of Zirconia Crowns Following Different Bonding Protocols, Suruchi Lamba
Retention Of Zirconia Crowns Following Different Bonding Protocols, Suruchi Lamba
All ETDs from UAB
Objective: To measure and compare the retention of zirconia crowns cemented with Ceramir (Calcium phosphate-based Bioactive Cement), RelyX Luting Plus (RMGI Cement) and RelyX Unicem (Self-adhesive resin cement) to extracted teeth following thermocycling. Methods: 30 sound extracted non-carious human molars were collected following IRB approval. The selected molars were notched at the roots and mounted into PVC molds filled with acrylic resin (Yates Motloid, USA). The occlusal surface was ground flat on a model trimmer. The axial reductions were performed with a standardized crown preparation device using a Komet 5845KR (“onlay”) diamond bur. A 10 degree ramp was used to …
Advances In The Creation And Use Of Genetically Modified Rodent Models, Laura Lambert
Advances In The Creation And Use Of Genetically Modified Rodent Models, Laura Lambert
All ETDs from UAB
Rodents have been the model of choice for decades in biomedical research due to their relatively high physiological similarity to humans and amenability to genomic modification. While transgenic constructs were first used in mouse blastocysts in 1974 and the first mouse embryonic stem (ES) cell line created in 1981, the lack of reliable methods to produce ES cells or culture embryos from the rat led to the limitation of its use in spite of several advantages such as larger size and higher genetic homology with humans. Use of genetic modification has recently expanded due to the advent of tailored nucleases …
Activation Of Ampk To Diminish Sepsis-Induced Lung Injury, Nathaniel Bone
Activation Of Ampk To Diminish Sepsis-Induced Lung Injury, Nathaniel Bone
All ETDs from UAB
Sepsis is the most frequent cause of death of hospitalized patients in modern ICUs. Severe infection, trauma, hemorrhage, burns, and surgery are significant causes of multi-organ injury and immune dysfunction that in turn primes for a high risk of secondary lung infections. In addition to detrimental inflammation, sepsis is linked to loss of metabolic plasticity due to mitochondrial dysfunction in immune cells and lung tissue. In particular, mitochondrial failure in lungs of critically ill septic patients is correlated with high mortality rates. We proposed that AMP-activated protein kinase (AMPK) activation, a major bioenergetic sensor and metabolic regulator, is a plausible …
Microenvironmental Regulation And Epigenetic Control Of Glioma Pathogenesis, Nathaniel H. Boyd
Microenvironmental Regulation And Epigenetic Control Of Glioma Pathogenesis, Nathaniel H. Boyd
All ETDs from UAB
Tumor microenvironments can promote stem cell maintenance, tumor growth, and therapeutic resistance, findings linked by the tumor initiating cell hypothesis. The ischemic microenvironment characterized by low oxygen and glucose, and acidic stress occurs in both solid tumors and non-neoplastic tissue injury. Standard of care for glioblastoma (GBM) includes the chemotherapy temozolomide, which is not curative due, in part, to residual therapy-resistant brain tumor initiating cells (BTICs). Temozolomide efficacy may be increased by targeting carbonic anhydrase 9 (CAIX), a hypoxia and acidic stress responsive gene important for maintaining the altered pH gradient of tumor cells. Using patient-derived GBM xenograft cells, we …
The Impact Of Mitochondrial Genetic Background On Development Of Complex Multifactorial Diseases, Alexander Wendell Bray
The Impact Of Mitochondrial Genetic Background On Development Of Complex Multifactorial Diseases, Alexander Wendell Bray
All ETDs from UAB
Complex multifactorial diseases such as cardiovascular disease (CVD) and cancer are a pervasive and inescapable component of modern society. However, the genetic elements that modulate individual susceptibility to these diseases remain poorly defined. Excessive mitochondrial oxidant production has been implicated in the initiation and progression of both CVD and cancer. Moreover, polymorphisms inherited on the mitochondria genome appear to influence mammalian mitochondrial function and oxidant generation. In the present study, mitochondrial-nuclear-eXchange (MNX) mice were used to directly assess the contribution of mitochondrial DNA (mtDNA) polymorphisms to atherosclerosis in the apoE deficient (apoE-/-) mouse model of hypercholesterolemia induced atherogenesis. ApoE-/- mice …
An In Vitro Evaluation Of Abutment Design For Anterior Zirconia Resin Bonded Restorations, Watcharapong Aroonsang
An In Vitro Evaluation Of Abutment Design For Anterior Zirconia Resin Bonded Restorations, Watcharapong Aroonsang
All ETDs from UAB
Resin-bonded fixed partial dentures (RBFPDs) have evolved from metal frameworks to esthetic all ceramic tooth colored restorations. However these restorations frequently fail due to a loss of retention of the retainers. As the frameworks for these restorations have changed to more esthetic ceramic materials, the search for the ideal conservative preparation design providing maximum retention is critical to improve the life span of these restorations. Purpose: This in vitro evaluation measured and compared the resistance and retention created with different abutment preparation designs with a zirconia framework. Method: 21 extracted human maxillary central incisors were divided into three groups of …
Cancer-Related Symptoms And Cognitive Intervention Adherence Among Breast Cancer Survivors: A Mixed Methods Study, Jennifer Bail
Cancer-Related Symptoms And Cognitive Intervention Adherence Among Breast Cancer Survivors: A Mixed Methods Study, Jennifer Bail
All ETDs from UAB
Advancements in screening, early detection, and treatment have increased breast cancer survival. In the United States, the 5-year relative survival rate for breast cancer is 89%. With more women surviving breast cancer, there are now more than 3.5 million breast cancer survivors (BCS), a figure estimated to increase to 4.3 million by 2020. Survivors experience long-term symptoms of their cancer and treatment which may last years and even decades after diagnosis and treatment. This symptom experience may potentially have exacerbating effects on BCS’ cognitive function as well as their ability to adhere to interventions aimed at improving cognitive function. The …
Incisor Contact In Optimal Occlusion, Ryan Baker
Incisor Contact In Optimal Occlusion, Ryan Baker
All ETDs from UAB
The objective of the present study was to grade the overjet of untreated plaster dental study casts with optimal occlusion utilizing the American Board of Orthodontics (ABO) Objective Grading System (OGS). Currently no data set exists for incisor contact norms in optimal occlusion. Materials and Methods: 140 Plaster dental study casts possessing optimal occlusion were utilized for this study. Study casts used were obtained from the office of Dr. Lawrence F. Andrews in San Diego, CA. The majority of the study models were those used in determining Andrews Six Keys to Normal Occlusion. Overjet was graded according to the ABO …
Exploring Psychosocial And Situational Factors That Influence Female College Students' Participation In Oral Sex, Margaret Bergeron
Exploring Psychosocial And Situational Factors That Influence Female College Students' Participation In Oral Sex, Margaret Bergeron
All ETDs from UAB
Although sexually transmitted infections (STI) are not officially reported via the route of transmission, the CDC (2016) reports that individuals who provide fellatio have the highest risk of oral transmission of a STI. Therefore, females who engage in fellatio are at risk for acquiring a STI. The majority of research studies on young adult heterosexual female sexual activities primarily focus on vaginal sex and the associated risks of pregnancy and sexually transmitted infections. Limited research exists on the oral sex behaviors of female college students and their understanding of the risk for contracting an STI through fellatio. The purpose of …
Extrasynaptic Signaling To Interneuron Networks, Angela Nietz
Extrasynaptic Signaling To Interneuron Networks, Angela Nietz
All ETDs from UAB
In recent years, a form of extrasynaptic signaling through fast neurotransmitters, termed spillover, has been shown in multiple brain regions. This discovery suggests that spillover is more ubiquitous than previously thought. The circuitry within the cerebellar cortex has been well mapped. However, glutamate from cerebellar climbing fibers (CF) has been shown to spill over to nearby interneurons and alter their tonic activity. Cerebellar Golgi cells are spontaneously active interneurons at the input stage to the cerebellar cortex re-sponsible for regulating influx of cortical information. Previous research has shown an in vivo connection between CFs and Golgi cells (GoC), with CF …
Hospital Purchasing Alliance: Contextual Factors And Financial Performance, William Opoku-Agyeman Opoku-Agyeman
Hospital Purchasing Alliance: Contextual Factors And Financial Performance, William Opoku-Agyeman Opoku-Agyeman
All ETDs from UAB
Collectively, the purpose of the three papers included in this dissertation was to provide empirical evidence on the contextual factors that influence hospital utilization of services of group purchasing organizations and how utilization of group purchasing organizations impacts hospitals’ financial performance. The findings of these studies are important both to researchers and to managers as it sheds light on the relationship between hospitals and group purchasing organizations. The results of this dissertation suggest that better financial performance is associated with hospital utilization of group purchasing organizations. Additionally, some measures of environmental munificence and dynamism are associated with hospital utilization of …
Lipid Biomarkers And Pathway Identification For Contact Lens Related Discomfort, Shyam Panthi
Lipid Biomarkers And Pathway Identification For Contact Lens Related Discomfort, Shyam Panthi
All ETDs from UAB
The purpose of this investigation was to identify possible lipid biomarkers that are associated with contact lens related discomfort and determine whether inflammation as a result of lipid peroxidation or enzymatic arachidonic acid metabolism is associated with such discomfort. Ten microliters of tears were collected from each eye of fifteen subjects (11 non-contact lens wearers, 2 contact lens wearers with discomfort and 2 contact lens wearers without discomfort) and assayed using various chemical extraction methods and mass spectrometry based analytical approaches. This was done to determine whether lipid mediators of inflammation could be identified in low volume (10 l) of …