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Articles 61 - 90 of 2525
Full-Text Articles in Medicine and Health Sciences
Effects Of Probiotic Lactobacilli On Candida Albicans: Implications For Early Childhood Caries, Leena Unnikrishnan Menon
Effects Of Probiotic Lactobacilli On Candida Albicans: Implications For Early Childhood Caries, Leena Unnikrishnan Menon
All ETDs from UAB
Purpose: Probiotic Lactobacillus species are shown to have beneficial effects against early childhood caries (ECC). On the other hand, the wide use of probiotic Lactobacillus spp. in dairy foods is believed to underline the global increase in ECC prevalence. Candida albicans has been frequently detected in children with ECC and has shown cariogenic potential in animal models of dental caries. The objective of this study was to determine the interactions between lactobacilli and C. albicans in growth competition, biofilm formation and acid production. Methods: Growth competition between C. albicans SC5314 and probiotic L. rhamnosus GG or caries-associated L. rhamnosus M72-26 …
Factors Associated With Early Onset Anal Cancer And Facilitators And Barriers To Screening Among Men Living With Hiv And Their Providers In The Deep South: A Mixed Methods Investigation, Anna Junkins
All ETDs from UAB
For my dissertation work, I aimed to 1) determine the occurrence of early onset (diagnosis at <50 years) anal cancer and the impact of HIV infection and other risk factors, and 2) utilize a mixed methods research approach to identify and explain factors associated with screening among men living with HIV (MLHIV) and their providers. In Aim 1, I used logistic regression to estimate the odds of early onset cancer by sociodemographic and clinical characteristics among anal cancer patients in the Alabama cancer registry from 2012-2018. Among 519 patients, 17.7% were diagnosed at <50 years. Male sex, Black race, and HIV infection were associated with younger age at diagnosis. Black patients had a 4-fold increased odds of early onset anal cancer compared to White patients and disproportionately lived in areas with higher social vulnerability. In Aim 2, I used logistic regression to estimate the odds of anal cancer screening by sociodemographic and sexual risk characteristics among MLHIV using retrospective survey data from 1917 Clinic in 2018. Among 1,114 men, 52% had received an anal pap within one year of completing the survey. Men who were screened were more likely to have multiple sexual partners. Heterosexual men had lower odds and men who reported unprotected anal sex had higher odds of screening. Older Black men were less likely to be screened. In Aim 3, I used thematic analyses to identify themes related to health beliefs, barriers and facilitators, and perceived and evaluated need of screening using in-depth interviews among MLHIV and their providers. Benefits of screening among MLHIV were early detection and awareness about one’s body. Suggestions for overcoming barriers to screening among providers included screening guidelines, patient education, inclusion of screening into routine care, and self-collection. Among men that were aware of HPV-associated cancers, there was perceived risk and desire to receive HPV vaccination. Individuals who are male, Black, or living with HIV may be at increased risk of developing anal cancer younger. Among MLHIV, improving education about HPV-associated cancer, and offering self-collected screening as part of routine care could facilitate screening in the South.
Cross-Sectional Retrospective Study To Determine The Prevalence Of Periodontal Bone Loss As A Function Of Age In The Predoctoral Clinic Patient Population, Lincoln Nguyen
All ETDs from UAB
Age has a significant effect on the body’s ability fight off disease, recover, and maintain collagen structures, and it has been observed that older adults have a higher prevalence of periodontal diseases. Studies have shown that age is a risk factor for alveolar bone loss. However, there is a lack of research done looking at if this is a linear progression or if there is a specific age that susceptibility increases. The aim of this study is to investigate (1) changes in radiographic bone loss in varying age groups in the University of Alabama patient population and (2) to evaluate …
Improving Direct Oncolytic Effect Of Oncolytic Hsv To Overcome Therapeutic Resistance Of Brain Tumors, Sam Edward Gary
Improving Direct Oncolytic Effect Of Oncolytic Hsv To Overcome Therapeutic Resistance Of Brain Tumors, Sam Edward Gary
All ETDs from UAB
Central nervous system tumors, especially malignant brain tumors, account for the most years of potential life lost in adults and children with cancer. Malignant brain tumors are typically fatal cancers due to their highly aggressive nature, inability to obtain gross total resection, location in sensitive brain areas, and intra- and intertumoral heterogeneity, making therapeutic targeting difficult. High-grade glioma (HGG), malignant brain tumors of glial cell origin invariably recur due to intrinsic and adaptive resistance mechanisms against standard therapies. Therefore, novel treatments that overcome therapeutic resistance are desperately needed. One promising approach is oncolytic viruses (OVs), which achieve tumor regression by …
Investigating Molecular Mechanisms Behind Neuronotypic Gba1 Mutations In Lewy Body Dementias, Casey Mahoney-Crane
Investigating Molecular Mechanisms Behind Neuronotypic Gba1 Mutations In Lewy Body Dementias, Casey Mahoney-Crane
All ETDs from UAB
Nonmotor deficits are present in nearly all Parkinson’s disease (PD) patients, with ~80% of these patients developing dementia. Importantly, expression of the severe GBA1 L444P heterozygous mutation increases the risk for Parkinson’s disease devel-opment by 5.43 times compared to mild mutation carriers. Currently, many PD treat-ments predominately focus motor symptoms, while treatments for nonmotor symptoms, such as visual-spatial difficulties and dementia, focus on symptom management and continue to remain elusive. Therefore, understanding the molecular mechanisms behind these nonmotor symptoms is essential for the development of effective therapeutics leading to slower disease progression. The work presented in this dissertation sought to …
O-Glcnacylation And Modulation Of Gabaergic Transmission, Shekinah Phillips
O-Glcnacylation And Modulation Of Gabaergic Transmission, Shekinah Phillips
All ETDs from UAB
Changes in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids. O-GlcNAcylation (O-GlcNAc) is a post-translational modification that is tightly regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which add or remove the O-GlcNAc moiety of β–N-acetylglucosamine to serine and threonine residues on proteins, respectively. Published reports from our lab have demonstrated that an acute increase in O-GlcNAcylation induces a long-term depression (LTD) of evoked GABAAR mediated IPSCs (eIPSCs) and reduces the amplitude and frequency of spontaneous IPSC (sIPSC) in hippocampal principal cells, however the mechanism in which this occurs is …
Elementary Cone Photoreceptor Signals In V1 Neurons, Cyril Nyankerh
Elementary Cone Photoreceptor Signals In V1 Neurons, Cyril Nyankerh
All ETDs from UAB
Daylight vision is initiated by the activation of cone photoreceptors in the retina in response to light, thereby generating spatial and temporal patterns of photoreceptor signals. Subsequent to this, the signals are combined and processed in downstream neural circuits, ultimately contributing to the formation of receptive fields of neurons in primary visual cortex (V1). Recent advances in adaptive optics (AO) have enabled imaging of the retina with near diffraction limited resolution, allowing for the probing of the visual system's processing at the resolution of individual cones. The central theme of this dissertation characterizes quantitively and qualitatively the physiological responses of …
Blood Transfusion Factors That Affect The Outcomes Of Patients Who Experienced Trauma-Related Hemorrhage, Justin Lee Miller
Blood Transfusion Factors That Affect The Outcomes Of Patients Who Experienced Trauma-Related Hemorrhage, Justin Lee Miller
All ETDs from UAB
Trauma is a leading cause of death in the United States and in the world. It is the leading cause of death of Americans between the ages of one to 45 years old and is expected to increase due to increase over the next ten years. Most trauma deaths are attributed to hemorrhage and are considered preventable. The current standard of care for trauma-related hemorrhage (TRH) is damage control resuscitation using either whole blood (WB) or blood components (BC) in a ratio of 1 unit of red blood cells to 1 unit of plasma to 1 unit of platelets. The …
The T Cell Response In A Mouse Model Of Multiple System Atrophy, Nicole Jane Corbin-Stein
The T Cell Response In A Mouse Model Of Multiple System Atrophy, Nicole Jane Corbin-Stein
All ETDs from UAB
Multiple System Atrophy (MSA) is a fatal and rare demyelinating synucleinopathy, characterized by the accumulation of alpha-synuclein (α-syn) in glial cytoplasmic inclusions (GCIs) within oligodendrocytes. This condition is marked by neuroinflammation, demyelination, and neurodegeneration in areas showing GCI pathology, involving antigen presentation by myeloid cells and infiltration of CD4+ and CD8+ T cells. Despite strong evidence of neuroinflammation in post-mortem MSA tissue, the specific mechanisms driving the disease pathogenesis remain elusive. In prior research using the Olig001-SYN mouse model, which involves the modified AAV vector, it was shown that depleting CD4+ T cells can reduce neuroinflammation and demyelination. Notably, this …
Impact Of Alpha-Synuclein Aggregates On Synaptic Structure In The Amygdala, Nolwazi Zakithi Gcwensa
Impact Of Alpha-Synuclein Aggregates On Synaptic Structure In The Amygdala, Nolwazi Zakithi Gcwensa
All ETDs from UAB
Parkinson’s disease is the most common motor neurodegenerative and is characterized by intracellular inclusions of misfolded protein α-synuclein termed Lewy Pathology. At least 80% of PD sufferers also experience non-motor symptoms along with, and sometimes preceding, the motor symptoms. Symptoms such as apathy, hallucinations, anxiety and depression could be caused by α-synuclein inclusions causing dysfunction in the amygdala. Lewy pathology in the amygdala of PD patients is robust and has also been observed in a number of other diseases like Dementia with Lewy Bodies and Alzheimer's disease. In our lab, we have shown that using preformed fibrils to induce α-synuclein …
The Effect Of Lower Limb Neuromuscular Electrical Stimulation On The Muscle And Metabolic Health After Acute Spinal Cord Injury, Amal Alharbi
All ETDs from UAB
Spinal cord injury (SCI) is a devastating event with long-term consequences for individuals and their families. It causes immediate disruption to neuronal pathways, leading to paralysis and loss of muscle function below the injury level. A few weeks after the injury, there is a rapid decline in contractile activity, muscle mass, and cross-sectional area. This leads to muscle fiber degeneration and a shift towards a higher proportion of fast glycolytic fibers, which are more prone to fatigue and less efficient in energy utilization. Severe muscle atrophy in SCI is closely linked to metabolic dysfunction, affecting overall health and rehabilitation recovery. …
Hydrogen Peroxide Regulates Protein N-Glycosylation, Alexandria Hernandez-Nichols
Hydrogen Peroxide Regulates Protein N-Glycosylation, Alexandria Hernandez-Nichols
All ETDs from UAB
N-glycosylation is a co- and post-translational modification wherein a variety of sugars are added to proteins in a linear pathway progressing from high mannose (HM) to hybrid, to complex type N-glycans. This modification is important to the understanding of protein maturation, stability, and function. Studies have shown that changes in cell N-glycomes, in particular, the HM N-glycan category, could be hallmarks of various pathologies. The biosynthetic pathway for N-glycosylation is well studied and the key enzymes involved in the progression of HM to hybrid N-glycans are the a-mannosidases. Little is understood about the regulation of this highly complex post-translational modification …
The Association Between Social Connectedness And Opioid Reuse Among Vulnerable Groups Receiving Medication For Opioid Use Disorder, Jolanda Lynn Hudson
The Association Between Social Connectedness And Opioid Reuse Among Vulnerable Groups Receiving Medication For Opioid Use Disorder, Jolanda Lynn Hudson
All ETDs from UAB
THE ASSOCIATION BETWEEN SOCIAL CONNECTEDNESS AND OPIOID REUSE AMONG VULNERABLE GROUPS RECEIVING MEDICATION FOR OPIOID USE DISORDER JOLANDA L. HUDSON PUBLIC HEALTH ABSTRACT Introduction: Opioid Use Disorder (OUD) is a serious illness that continues to persist despite the many efforts of researchers, physicians, government agencies, state, and local programs, to eliminate the mortality rate associated with this disease. Although manageable, OUD is still taking the lives of citizens due to illegal opioid misuse. Understanding the dynamics of the disease and the contributing factors in various populations may inform researchers in successful intervention outcomes. Methods: A retrospective secondary data analysis utilizing …
Changes In Drug And Alcohol Behaviors Before And After An Educational Intervention Among At-Risk Adults And Youth, Isabel Cuellar Acker
Changes In Drug And Alcohol Behaviors Before And After An Educational Intervention Among At-Risk Adults And Youth, Isabel Cuellar Acker
All ETDs from UAB
Introduction: Substance abuse is defined as the excessive use of a drug in a way that is detrimental to oneself, society, or both. Gender is important to examine because it is becoming more common for females to develop substance use disorders and for their substance use to be more severe. This study will address the role of an education-based intervention on substance abuse in an area that is at the intersection of rural and urban geography with a unique pool of participants. Methods: This is a longitudinal cohort study that has a pre-post intervention design. A linear model was used …
Prevention Of Spina Bifida Through Fortification Of Iodized Salt With Folic Acid, Anastasia Arynchyna Smith
Prevention Of Spina Bifida Through Fortification Of Iodized Salt With Folic Acid, Anastasia Arynchyna Smith
All ETDs from UAB
The overarching goal of the three-paper dissertation is to address the gaps in the literature on the clinical care burden of preventable spina bifida on the global neurosurgical community and the need for a universal food vehicle for fortification with folic acid as a novel prevention strategy. It is known that sufficient intake of folic acid is imperative to prevent neural tube defects (spina bifida) in the developing fetus in the first month post-conception. It is also known that fortifying staple foods is the most cost-saving and effective prevention method. However, very few countries have mandatory fortification policies. Therefore, the …
Interactions Between Oral Cancer Cells And Enterococcus Fecalis And Their Impact On Perineural Invasion, Sree Ramya Bhamidipaati
Interactions Between Oral Cancer Cells And Enterococcus Fecalis And Their Impact On Perineural Invasion, Sree Ramya Bhamidipaati
All ETDs from UAB
Oral and oropharyngeal squamous cell cancers (OSCC and OPSCC) are some of the most common cancers in the world. The overall 5-year survival rate is 68.5%, which drops to 39.3% in patients with later-stage cancers. This research aims to evaluate the effects of Enterococcus faecalis (E. faecalis) on the OSCC and OPSCC's tumor progression. E. faecalis is associated with asymptomatic, persistent endodontic infections and was found at a higher rate in OSCC patients. We hypothesize that cancer cells and Enterococcus faecalis (Ef) interact to affect the tumorigenic properties of oral cancer cells. OSCC cells from different parts of the oral …
It's A Man's World: The Association Between Safe Sex Practices, Relationship Power, & Resilience Among African American Emerging Adults Between 18-24 In The Deep South, Jessica Morgan
All ETDs from UAB
The purpose of this dissertation was to examine the impact that power imbalance has on safe sex practices among African American emerging adults. The objectives included: provide a thorough review of preexisting literature that explores the impact of power imbalance on safe sex practices among African American women; understand the impact that power imbalance has on safe sex practices among African American emerging adults comparing data from men and women; and understand if resilience is associated with power imbalance among African American emerging adult women in the United States. Utilizing a retrospective, cross-sectional, quantitative study design, three methods were used …
Understanding Biopsychosocial Influences On Physical Activity And Quality Of Life In Breast Cancer Survivors, Erica A. Schleicher
Understanding Biopsychosocial Influences On Physical Activity And Quality Of Life In Breast Cancer Survivors, Erica A. Schleicher
All ETDs from UAB
Receiving a breast cancer diagnosis and subsequent treatment can be life-altering, presenting numerous challenges. Breast cancer treatments are effective at allowing women to live longer, but often impose long-term side-effects that survivors must manage for years. Exercise is an effective way to address many long-term side-effects of breast cancer treatment, yet 63-83% of breast cancer survivors do not meet recommended physical activity (PA) guidelines. Due to the complexity of cancer and treatment options, cancer-related factors have potential biopsychosocial impacts that can influence exercise habits, attitudes toward PA (i.e., social cognitive theory (SCT) constructs), and potentially quality of life (QoL). It …
The Effect Of Progranulin On Lysosomal Function In Bv2 Cells, Michelle Park
The Effect Of Progranulin On Lysosomal Function In Bv2 Cells, Michelle Park
All ETDs from UAB
Neurodegenerative diseases afflict nearly 7 million people in United states, constituting a significant portion of the 600 known neurological disorders. Characterized by the gradual loss of neurons and axons within the central nervous system (CNS), these conditions stem from chronic inflammatory activation of the brain. Chronic inflammation disrupts important processes such as autophagy lysosome pathway, a self-degradative process that eliminates protein aggregates and damaged organelles. Trehalose, a non-reducing disaccharide that triggers autophagic flux in neuronal cells and promotes the clearance of protein aggregates; however, without understanding the mechanism behind how trehalose affects these functions, it lacks value. In our study, …
Physical And Optical Properties Of Material Used For Injection Molding, Nadia Christine Farias Machado
Physical And Optical Properties Of Material Used For Injection Molding, Nadia Christine Farias Machado
All ETDs from UAB
Background: This project investigates the materials used in injection molding dental resin composites which involves injecting flowable composite into a clear mold. Understanding the physical and optical properties of both the resin composite and the clear mold material is crucial for successful clinical outcomes. For the clear mold material, its translucency, curing light transmission, and rigidity are vital factors. Correlations may be present between trans-lucency and curing light transmission. For the resin composite, comparing wear, hardness, translucency, radiopacity, shrinkage stress, flexural strength, and modulus will affect mate-rial performance. Finally, the depth of cure of the material will be dependent on …
Psychometric Evaluation Of A Perceived Barriers To Medication Adherence Instrument And Association Between Perceived Barriers And Patient Characteristics, Lynn Andreae
All ETDs from UAB
Medication adherence is an important component of diabetes management, yet nonadherence is common and has substantial patient and economic costs. In order to achieve meaningful improvements in medication adherence, clinicians and researchers need good ways of both identifying those at risk of nonadherence and ascertaining the specific reasons driving nonadherence in those patients. Current options for self-reported medication adherence are limited in their vulnerability to response bias, which may lead to overestimation of adherence. A measure that assesses perceived barriers to medication adherence may be a useful alternative, as it may identify patients at risk of nonadherence while reducing socially …
The Role Of Fibroblast Growth Factor Receptors In Inflammatory Airway Diseases, Molly Easter
The Role Of Fibroblast Growth Factor Receptors In Inflammatory Airway Diseases, Molly Easter
All ETDs from UAB
Chronic inflammation plays a role in the development and progression of airway diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). COPD is caused primarily by chronic cigarette smoke exposure. Conversely, CF is a single gene disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). Although the causes of COPD and CF are different, there are common pathological features. Studies show that chronic inflammation plays a significant role in the pathogenesis of both COPD and CF. Moreover, chronic inflammation induces ageing-associated pathomechanisms like cellular senescence, which exacerbates chronic inflammation. Previous work demonstrates that …
The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry
The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry
All ETDs from UAB
Temporal Lobe Epilepsy (TLE) is the most prevalent form of focal epilepsy and the most treatment-resistant type. This condition is characterized by recurrent, unprovoked seizures typically originating in the hippocampus. Epigenetic modifications such as DNAme changes have been implicated in brain functions such as synaptic plasticity, learning and, memory, and cognition. The oxidation of DNA 5-methylcytosine (5-mC) and its oxidized form, 5-hydroxymethylcytosine (5-hmC) catalyzed by Ten-Eleven Translocation (TET) family of dioxygenases and linked to epilepsy's hyperexcitable state. Post‐translational modifications (PTMs) of proteins, such as O-GlcNAcylation, facilitate cells' immediate responses to intracellular or extracellular environmental stimuli by modifying the functions of …
Investigating Hiv-1 Transmission To Human Cervix Using Reporter Virus Technologies, Dana Frances Indihar
Investigating Hiv-1 Transmission To Human Cervix Using Reporter Virus Technologies, Dana Frances Indihar
All ETDs from UAB
Around 39 million people globally are currently infected with Human immunodeficiency virus 1 (HIV-1), more than half of whom are women. HIV-1 is a retrovirus that infects and depletes an individual’s immune cells, culminating in the development of acquired immunodeficiency syndrome (AIDS) if not managed with anti-retroviral therapies (ART). Most women acquire HIV-1 through heterosexual intercourse. However, the early mechanisms and virologic determinants of HIV-1 transmission to women remain unclear. Herein, we demonstrate transmitted/founder (TF) HIV-1 representing two genetically and pathogenically distinct subtypes (A and D) in vivo have distinct replication phenotypes in an ex vivo cervical explant tissue (CET) …
The Prescription Drug Monitoring Program And Its Effect On Drug Overdose Mortalities, Charles Lee
The Prescription Drug Monitoring Program And Its Effect On Drug Overdose Mortalities, Charles Lee
All ETDs from UAB
The opioid epidemic is a growing concern, and the health and economic impacts on rural and urban counties are increasing. Between 1999 and 2019, approximately 841,000 people died from drug overdoses involving heroin, synthetic opioids, and prescribed opioids with 71,000 dying in 2019. This study examined the relationship between drug overdose mortalities and three independent variables, (a) Medicaid expansion, (b) Years PDMP active, and (c) Academic detailing engagement. Results of this study will contribute to the literature by determining if the Medicaid expansion, years prescription drug monitoring programs active, and academic detailing engagement decrease drug overdose mortalities. This study includes …
Examining Anti-Racist Attitudes In Maternity Care Workers, Angelina Aduke Toluhi
Examining Anti-Racist Attitudes In Maternity Care Workers, Angelina Aduke Toluhi
All ETDs from UAB
Racism in maternity care has been identified as one of the major contributors to the persistent racial disparities in maternal health outcomes in the United States (US). Antiracism is a term used to describe the practice of actively identifying and opposing racism with the goal of changing policies, attitudes, behaviors, and beliefs that continue to foster racist ideas and actions. The results of this convergent mixed method research study reveal that racism and other forms of racial discrimination during maternity care may lead to adverse pregnancy outcomes in Non-Hispanic Black (NHB) pregnant patients in Southern US. In the first aim, …
Non-Catalytic Regulators Of The Secretory Pathway, Peyton Vanwinkle
Non-Catalytic Regulators Of The Secretory Pathway, Peyton Vanwinkle
All ETDs from UAB
This thesis focuses on two key questions: 1) how are bone development and regeneration regulated by the CREB3L1 transcription factor; and 2) what is the mechanism of action of the endoplasmic reticulum resident protein JAGN1, which when dysregulated, causes severe congenital neutropenia (SCN)? CREB3L1 regulates bone development and regeneration in mammalian models by facilitating the expression of COL1A1 and components of the secretory pathway required for collagen secretion. We generated two zebrafish models of Creb3l1 dysfunction (creb3l1ΔbZIP/ΔbZIP and creb3l1TA+/TA+). Both models showed that Creb3l1 functions in regulating col1a1a transcription and overall regenerate size are conserved in zebrafish. However, we also …
Screening For And Addressing Social Determinants Of Health In Hospitals Participating In Accountable Care Organizations, Heather Lee
All ETDs from UAB
There is a growing recognition among hospitals, payers, and policymakers in the United States that addressing social needs of patients is important to improving quality of care, patient outcomes, and lowering health care spending. Accountable care organizations (ACOs) may be especially incentivized to address social needs of patients to meet population health goals related to patient outcomes and costs. This cross-sectional study used data from the American Hospital Association Annual Survey to explore to explore how hospitals participating in or leading ACOs are screening for and addressing individual-level HRSNs of patients and to understand the extent to which ACOs are …
The Multifaceted Role Of Neutrophil Heterogeneity In Covid-19 Pathogenesis, Marcus Darrell Davis
The Multifaceted Role Of Neutrophil Heterogeneity In Covid-19 Pathogenesis, Marcus Darrell Davis
All ETDs from UAB
COVID-19 is a respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The disease is characterized by an excessive inflammatory response and dysfunction of the immune system triggered by immunopathological mechanisms. Neutrophils are the most abundant circulating leukocytes, playing a critical role in the pathogenesis of multiple inflammatory conditions. Several studies have demonstrated that neutrophils are key contributors to COVID-19 disease pathogenesis; however, their role in disease progression remains unclear. Here, we demonstrate immune dysregulation in COVID-19 patients characterized by a significant expansion of neutrophil numbers and reduced frequency of T-cell populations. We identify an immature …
Unmasking Molecular Mechanisms Of Multiple Maladies Through Multiomic Methodologies, Luke Potter
Unmasking Molecular Mechanisms Of Multiple Maladies Through Multiomic Methodologies, Luke Potter
All ETDs from UAB
Much modern biomedical research is invested in determining causative molecular mechanisms and identifying potential therapeutics within human disease or injury. Traditional experiments such as over-expressing or “knocking out” the level of a gene’s abundance can determine the specific contribution of a single gene to a pathology and are a vital component of scientific research. However, taking a big picture approach through the application of ‘omics technologies can lead to a broader overall understanding of a pathology and can potentially generate numerous specific hypotheses to be tested using the more traditional molecular approaches. In this dissertation, transcriptomic and epigenomic technologies, measuring …