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Articles 481 - 510 of 2525
Full-Text Articles in Medicine and Health Sciences
Gait Adaptability With Healthy Aging And Parkinson’S Disease, Daniel Kuhman
Gait Adaptability With Healthy Aging And Parkinson’S Disease, Daniel Kuhman
All ETDs from UAB
Human locomotion often occurs through environments with complex sets of external demands (e.g., obstacles, uneven surfaces, altered terrain, etc.). Fortunately, humans have developed locomotor systems capable of rapidly adapting gait patterns to navigate these environments. Advanced age and neurological disorders such as Parkinson’s disease (PD) are associated with physiological changes that add to the complexity of locomotion – these individuals must not only adapt to changing environmental demands, but also to changes in internal function (e.g., reduced muscle strength, dysfunctional sensorimotor integration). While there is a growing body of literature indicating that healthy older adults maintain adaptability, less is known …
Inducible T Cell Costimulator Stabilizes Regulatory T Cell Phenotype And Controls Host-Microbiota Interactions To Reduce Susceptibility To Intestinal Inflammation, Ashley Elizabeth Landuyt
Inducible T Cell Costimulator Stabilizes Regulatory T Cell Phenotype And Controls Host-Microbiota Interactions To Reduce Susceptibility To Intestinal Inflammation, Ashley Elizabeth Landuyt
All ETDs from UAB
Genome wide association studies (GWAS) have identified a loss-of-function mutation in the gene encoding inducible T cell costimulator ligand (ICOSL) as correlating with inflammatory bowel disease (IBD). The reason for this association was largely unknown. ICOS signals have been implicated in controlling the dynamics of regulatory T (Treg) cells, which are essential to intestinal homeostasis. Compared to WT mice, ICOS-deficient mice possessed fewer Treg cells in the colonic lamina propria (cLP). The deficit in ICOS-deficient Treg cell numbers was attributable to preferential loss of Foxp3 expression. Bisulfite sequencing revealed that ICOS-deficient Treg cells did not demethylate conserved noncoding sequence 2 …
The Association Between Medicaid Expansion, Medicaid Disproportionate Share Payments And The Financial Performance Of Safety Net Hospitals, Jon Law
All ETDs from UAB
Safety Net Hospitals (SNHs) provide necessary emergency and acute care to all individuals, regardless of their ability to pay for health care. Medicaid Expansion and Disproportionate Share (DSH) payments are two Medicaid programs that may mitigate the financial vulnerability of SNH’s. Some assert that Medicaid Expansion, as part of the Patient and Affordable Care Act (ACA), may provide financial relief for SNHs. It offers payment mechanisms for millions of uninsured individuals. DSH expenditures per capita for each state vary widely. There is some likelihood that SNHs in some states may benefit greater than others. The study was framed within the …
Chemical, Physical, And Antibacterial Properties Of Contemporary Pulp Capping Materials, Yu-Yin Lin
Chemical, Physical, And Antibacterial Properties Of Contemporary Pulp Capping Materials, Yu-Yin Lin
All ETDs from UAB
The purpose of this project was to compare the chemical, physical, and antibacterial properties of right contemporary direct pulp capping materials. The material categories included in this study were calcium hydroxide (Dycal, Lime-Lite and Ultra-Blend plus), calcium silicate (MTA Angelus, Biodentine, TheraCal LC), calcium aluminate (Ceramir Protect LC), and resin ionomer (Bio-Cap). Calcium release and pH changes were measured via a calcium ion-selective electrode (Vernier Company) and pH sensor (Vernier Company) respectively, after specimens were immersed in 36.8oC deionized water for 1, 7, 28 and 90 days. Water solubility was calculated with weight loss of the specimens from 0 to …
Mucus Matters: Mucociliary Physiology In Chronic Lung Diseases, Jacelyn Emily Peabody Lever
Mucus Matters: Mucociliary Physiology In Chronic Lung Diseases, Jacelyn Emily Peabody Lever
All ETDs from UAB
The mucociliary escalator is an innate defense mechanism in the lung comprised of the ciliated, pseudostratified epithelium that lines the conducting airways and the mucus that sits atop the cilia. Mucus traps inhaled particulate matter/pathogens, and the cilia brush works in concert to propel the mucin gel proximally. Therefore, proper mucociliary physiology is critical to maintaining lung health. A metachronal wave propagated across the epithelium can occur when the phase of the ciliary stroke is shifted in time relative to its neighbors. Metachrony has been hypothesized to help overcome the viscoelastic forces required for the propulsion of mucus. Still, its …
Implications Of Genetic Variation On Patient Disease And Therapeutic Options, Ashlee Long
Implications Of Genetic Variation On Patient Disease And Therapeutic Options, Ashlee Long
All ETDs from UAB
Advancements in sequencing technology have enabled the widespread utilization of genetic testing, increasing the diagnosis and understanding of genetic disease. Clinicians and researchers are now faced with the difficulty of interpreting genetic results and understanding how genetic variation can impact patient disease phenotype. Herein we utilized three different genes (frataxin, neurofibromin 1, and NTRK2), which result in Friedreich’s Ataxia (FRDA), Neurofibromatosis Type 1 (NF1), and NTRK2-associated phenotypes respectively, to discuss the impacts of genetic variants on molecular phenotype and explore potential therapeutics. To determine how genetic variation of repeat sequences affects different patient tissues, DNA and protein were extracted from …
The Role Of Race, Sex, And Place In The Association Of Diabetes And Cardiovascular Disease, Gargya Malla
The Role Of Race, Sex, And Place In The Association Of Diabetes And Cardiovascular Disease, Gargya Malla
All ETDs from UAB
Cardiovascular disease risk is higher among adult with diabetes than those without diabetes. This increase in risk may vary by race, sex, and neighborhood characteristics. Recent US data showed a resurgence in stroke and coronary heart disease (CHD) among adults with diabetes, and an increase in heart failure (HF) mortality. Therefore, this dissertation investigated how cardiovascular disease risk may vary by race, sex, and neighborhood characteristics for adults across the glycemic spectrum.Data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, an ongoing prospective cohort of 30,239 Black and White adults age 45 years at baseline (2003-07) …
Investigating Pathological Features Of Tdp-43 In Neurodegeneration, Joshua Mathew Marcus
Investigating Pathological Features Of Tdp-43 In Neurodegeneration, Joshua Mathew Marcus
All ETDs from UAB
Transactivation response element (TAR) DNA binding protein of 43 kDa (TDP-43) is an essential RNA-binding protein required for coordinating multiple aspects of RNA metabolism. TDP-43 is multifunctional in both nuclear and cytoplasmic cellular compartments and shuttling in and out of the nucleus is an integral part of TDP-43 function. Nuclear depletion and cytoplasmic accumulation of TDP-43, aggregation of TDP-43 within inclusion bodies in the cytoplasm, and aberrant post-translational modifications and truncation of TDP-43 are all common pathological features of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD). Localization of TDP-43 is connected to essential …
Delineation Of B Cell Follicle Associated Cd4+ T Cell Subsets, Ryan James Mcmonigle
Delineation Of B Cell Follicle Associated Cd4+ T Cell Subsets, Ryan James Mcmonigle
All ETDs from UAB
High affinity antibody responses rely on the interaction between CD4+ T cells andB cells, but these cell populations are segregated into different regions of secondary lymphoid organs (SLO). Early-stage follicular helper CD4+ T cells (Tfh cells) upregulate the B cell follicle-homing chemokine receptor CXCR5 in order to move from the T cell zone to the B cell follicle and establish interactions with cognate B cells that are essential for T-dependent humoral immune responses. Cognate Tfh and B cell interactions progress to the formation of germinal center (GC) reactions, where B cell receptors undergo rapid evolution to substantially increase antigen recognition …
Omics Discovery For Cardiometabolic Traits In African Americans, Bre Ashanti Minniefield
Omics Discovery For Cardiometabolic Traits In African Americans, Bre Ashanti Minniefield
All ETDs from UAB
Research shows African Americans are more likely to suffer from a chronic disease compared to other American populations. Due to the fact that African Americans are extremely underrepresented within human health research, the potential biological causes of the racial/ethnic differences are not well understood. Some of these health differences may be due to genomic variations within either the mitochondrial genome, nuclear genome, or both. To aid the revolution of inclusive human health research, we examined genomic factors related to cardiometabolic diseases in African Americans.African Americans have the highest prevalence of hypertension compared to all other American populations. With the majority …
Value Analysis Of Electronic Health Records, Shikha Shah Modi
Value Analysis Of Electronic Health Records, Shikha Shah Modi
All ETDs from UAB
The Electronic Health Record (EHR) is defined as “a longitudinal electronic record of patient health information generated by one or more encounters in any care delivery setting” (HIMSS, 2011). EHRs have become an important part of the current health system as a result of government regulations, technology advancements, health care challenges, and market conditions. EHRs are considered an expensive investment; however, the complexity of adopting and implementing EHRs also demands attention. Given the complexity of health information technology (HIT) systems and the hefty investment that is required in the adoption of EHRs, a return on investment is expected, and it …
Alternative Splicing Of Anxa7 Dictates Receptor Tyrosine Kinase Fates In Glioblastoma, Sindhu Nair
Alternative Splicing Of Anxa7 Dictates Receptor Tyrosine Kinase Fates In Glioblastoma, Sindhu Nair
All ETDs from UAB
Alternative splicing (AS) is a tightly regulated process essential for lineage specification in complex tissues like the brain. Dysregulated splicing in glioblastoma (GBM) is a mechanism exploited by tumor cells to retain or splice out exons consequently rewiring isoform-specific protein interactions to sustain tumor phenotypes. Receptor tyrosine kinases (RTK) amplifications are frequent events in GBM driving tumor growth and progression and are key targets for chemotherapy. However, RTK targeting in GBM has achieved limited success predominantly due to adaptive mechanisms of resistance in a constantly evolving tumor microenvironment. Clonal populations and crosstalk between RTKs sustain heterogeneity within a tumor leading …
The Effects Of Implantoplasty On Implant Design Characteristics And Mechanical Strength, Peter Nasseh
The Effects Of Implantoplasty On Implant Design Characteristics And Mechanical Strength, Peter Nasseh
All ETDs from UAB
Implantoplasty is defined as the mechanical removal of the implant threads and the macroscopically rough implant surface. Clinical outcomes such as probing depth and bleed-ing on probing measurements were shown to improve significantly after implantoplasty and peri-implant bone stability was achieved in the majority of the cases.This in-vitro study aims to investigate the effects of implantoplasty on the implant’s maximum compressing force and the type of failure that occurred on different implant sys-tems with different sizes, materials, collar designs and prosthetic connections. A total of 132 screw-shaped titanium implants from different manufacturers (Bi-oHorizons, Zimmer Biomet, and Nobel Biocare) and different …
Effectiveness Of Maxillary Molar Intrusion With The Invisalign System For Correction Of Anterior Open Bites, Logan Icenhour
Effectiveness Of Maxillary Molar Intrusion With The Invisalign System For Correction Of Anterior Open Bites, Logan Icenhour
All ETDs from UAB
Objective: The purpose of this study is twofold: To assess the amount of molar intrusion that can be predictably be achieved with clear aligners (Invisalign, Align Technology, Santa Clara, CA, USA) and to quantitatively document the dental and skeletal changes resulting from anterior open bite correction. Methods: This retrospective case-series study analyzed lateral cephalograms of 23 adult anterior open bite patients treated with Invisalign. Pre-treatment (IN) and post-treatment (FN) cephalograms were traced to determine changes as a result of treatment. 13 different variables were measured, 6 angular and 7 linear. All patients were treated consecutively by a single, experienced Invisalign …
Financial Performance Of Participating Hospitals In Accountable Care Organizations, Abdulrhman Alzhrani
Financial Performance Of Participating Hospitals In Accountable Care Organizations, Abdulrhman Alzhrani
All ETDs from UAB
The study examines the influence of accountable care organizations ACO participation on hospital financial performance. It poses two research questions: 1) how does ACO participation influence hospital financial performance? 2) How do organizational factors- hospital size, electronic health records (EHR) utilization, and ambulatory services- moderate the relationship between hospital ACO participation and financial performance? The study used longitudinal sample of general and surgical hospitals operating in United States from 2009 to 2017. The data were obtained from several sources including American Hospital Association (AHA), AHA survey of care system and payment, hospital cost reports, AHA information technology and Area Health …
The Effect Of Medicaid Expansion On Hospitals Allowance For Bad Debt, Tara B. Dixon
The Effect Of Medicaid Expansion On Hospitals Allowance For Bad Debt, Tara B. Dixon
All ETDs from UAB
The management of bad debt is a complex issue for hospitals, and if mismanaged, can impact the organization's current and future financial stability. The expansion of Medicaid through the Patient and Affordable Care Act (ACA) was expected to lessen the bad debt reported by hospitals by increasing the number of insured lives. Hospital managers understand that a certain percentage from the accounts receivables will end up being uncollectable; however, strategically planning for bad debt and estimating a more accurate allowance requires a specific level of strategic planning. Allowance for bad debt should not be a guessing game but should be …
An Airway Analysis Of Patients Diagnosed With Juvenile Idiopathic Arthritis Compared To A Control Group, Matt Gibson
An Airway Analysis Of Patients Diagnosed With Juvenile Idiopathic Arthritis Compared To A Control Group, Matt Gibson
All ETDs from UAB
Introduction: The temporomandibular joint (TMJ) is affected in 30-45%% of Juvenile Idiopathic Arthritis (JIA) patients, with all JIA subtypes at risk for TMJ involvement. JIA patients with TMJ involvement may present with altered craniofacial morphology, including micrognathia, mandibular retrognathia, a hyperdivergent mandibular plane angle, and skeletal anterior open bite. These features are also commonly present and associated with non-JIA pediatric patients with obstructive sleep apnea (OSA). Materials and Methods: The study comprised of a group of 32 JIA patients and a group of 32 healthy control subjects. CBCT images were taken for all patients and were imported into Dolphin Imaging …
Risk Of Coronary Heart Disease In Blood Of Marrow Transplant Survivors, Radhika Gangaraju
Risk Of Coronary Heart Disease In Blood Of Marrow Transplant Survivors, Radhika Gangaraju
All ETDs from UAB
Background: Blood or marrow transplant (BMT) recipients are vulnerable to accelerated atherosclerosis due to prior exposure to chemotherapy and radiation, and consequent long-term cardiovascular morbidity, such as coronary heart disease (CHD). A comprehensive evaluation of the risk of late-occurring CHD in adult BMT survivors and the associated risk factors has not been performed. Patients and Methods: Using the Blood or Marrow Transplant Survivor Study (BMTSS), we analyzed the incidence and risk factors for CHD in patients who underwent BMT between 1974 and 2014, and survived ≥2 years. The risk of CHD was examined in BMT survivors as compared to 1,131 …
Maxillary And Mandibular Expansion Treatment With Invisalign First: A Retrospective Study Of Virtual Prediction Versus Clinical Outcomes, Laura Constanza Rey Londono
Maxillary And Mandibular Expansion Treatment With Invisalign First: A Retrospective Study Of Virtual Prediction Versus Clinical Outcomes, Laura Constanza Rey Londono
All ETDs from UAB
Introduction: The purpose of this retrospective study is to evaluate the maxillary and mandibular expansion achieved with Invisalign First (Align Technology, San Jose, CA) in growing children. Methods: Clinical stereolithography (STL) models of 32 patients in the mixed dentition stage, treated with the Invisalign First, were extracted from the ClinCheck software and analyzed in Dolphin imaging (version 11.95 Premium, Chatsworth, Calif) at three timepoints: T1 (initial records), T2 (virtual outcome prediction), and T3 (achieved outcome). The recorded measurements included: upper and lower primary intercanine and permanent intermolar width, upper and lower primary intercanine and permanent intermolar gingival width, upper arch …
An Analysis Of Preterm Birth Related To Sars-Cov-2 Infection By Race, Madeleine B. Mcgwin
An Analysis Of Preterm Birth Related To Sars-Cov-2 Infection By Race, Madeleine B. Mcgwin
All ETDs from UAB
Research investigating the association between pregnant women with COVID-19 infection and adverse birth outcomes, including preterm birth, having been contradicting. Individual differences between study populations, e.g., racial composition, may explain some of these inconsistencies. The aim of the present study is to determine if the association between SARS-CoV-2 infection and pre-term birth varies according to race. A cross-sectional study was conducted using data from the Vizient Clinical Data Base/Research Manager (CDB/RM). The study participants were women who gave birth in one of the Vizient facilities between March 2020 and January 2021. A positive COVID-19 test status was the primary exposure …
The Role Of Cd38 In Anti-Tumor Immunity And Tumor Immune Evasion, Panpan Yuan
The Role Of Cd38 In Anti-Tumor Immunity And Tumor Immune Evasion, Panpan Yuan
All ETDs from UAB
CD38 is a multifunctional protein that is expressed in many immune cells, modulating NAD metabolism, inflammation and oxidative stress. Recent studies suggest that CD38 is also implicated in tumor immunosuppression. However, the role of CD38 in anti-tumor immunity and tumor immune evasion, and mechanisms involved, are still unclear. We hypothesized that CD38 expression by immune cells constricts T cell-mediated anti-tumor immune responses and promotes tumor cell immune evasion. We investigated whether mice lacking CD38 (CD38-/-) had impaired tumor growth in subcutaneous, intraperitoneal and intravenous syngeneic tumor models. CD38-/- mice showed no difference in subcutaneous B16 melanoma tumor growth and pulmonary …
Evaluation Of The Bonding Strength Between Different Materials And Resin Cement Used For Cementing A Fixed Complete Prosthesis, Vinita Pankaj Ved
Evaluation Of The Bonding Strength Between Different Materials And Resin Cement Used For Cementing A Fixed Complete Prosthesis, Vinita Pankaj Ved
All ETDs from UAB
Statement of Problem: When a situation of full-arch edentulism is observed, CAD-CAM designed prosthesis have improved properties in comparison to conventional fixed dentures. Long term longevity of the prosthesis includes not only strength of the framework, but also enhanced bonding strength between the framework and implant coping. Purpose: To investigate the bonding strength between different polymer materials used for a monolithic metal-free fixed hybrid denture luted to Ti-Base using the push-out strength test. Materials and Methods: The experimental design consists of 20 specimens for each group, with a total of 7 groups (total = 140). The materials used in the …
Experience-Dependent Plasticitiy Of Functional Connectivity In Human Visual Cortex Following Central Vision Loss, Leland Lanelle Fleming
Experience-Dependent Plasticitiy Of Functional Connectivity In Human Visual Cortex Following Central Vision Loss, Leland Lanelle Fleming
All ETDs from UAB
The human brain is shaped by a dynamic interplay between innate factors and life experiences. Neuroscience has long grappled with understanding this relationship, particularly with regard to how changes in experience impact the brain during adulthood. This question is especially important in the context of macular degeneration, a disease that causes significant visual impairment and drastically alters day-to-day visual experiences for individuals afflicted by the disease. Specifically, people with macular degeneration lose the ability to use vision in the center of the visual field, the region of the retina with the highest spatial resolution. Subsequently, these individuals must rely on …
Regulation Of Nitric Oxide Syntahse 3 By Histone Deacetylase, Luke S. Dunaway
Regulation Of Nitric Oxide Syntahse 3 By Histone Deacetylase, Luke S. Dunaway
All ETDs from UAB
In the vasculature, nitric oxide is produced by nitric oxide synthase 3 (NOS3) and protects against the development of cardiovascular disease (CVD). The histone deacetylases (HDACs) are a family of enzymes responsible for lysine deacetylation of both histone and non-histone proteins. Understanding how NO signaling is regulated by HDACs will allow us to better understand how HDAC inhibitors may be of use in treating CVD. This dissertation seeks to provide novel insight into the regulation of NOS3 by this family of enzymes. Endothelial NO production is impaired in human subjects and rodents fed a high salt diet (HS). We have …
The Impact Of Blimp1 On Etreg Stability And The Tumor Microenvironment, Michael Dixon
The Impact Of Blimp1 On Etreg Stability And The Tumor Microenvironment, Michael Dixon
All ETDs from UAB
CD4+ Foxp3+ regulatory T (Treg) cells are responsible for maintaining immunological homeostasis and self-tolerance through the regulation of immune responses against foreign and self-antigens, and they comprise both central Treg and effector Treg (eTreg) subsets. Because of their ability to suppress potent immune responses, eTreg cells expressing the transcription factor Blimp1 are frequently recruited to the tumor microenvironment (TME) to suppress anti-tumor responses by tumor infiltrating effector cells. Here, we demonstrate in murine transplantable tumor models that Blimp1 is required for intratumoral eTreg stability and that loss of Blimp1 by intratumoral eTreg cells results in their reduced suppressive activity and …
Challenges For Nurse Anesthetists Re-Entering Practice Following Substance Use Disorder Treatment, T'Anya Marye Carter
Challenges For Nurse Anesthetists Re-Entering Practice Following Substance Use Disorder Treatment, T'Anya Marye Carter
All ETDs from UAB
Substance use disorder (SUD) is a persistent, relapsing condition that is present in approximately 10% of anesthesia providers, who, compared to other healthcare providers, face a greater risk of developing an SUD by virtue of constant access to medications. The ability of Certified Registered Nurse Anesthetists (CRNAs) to obtain employment or maintain employment after treatment for SUD treatment is not well documented. CRNAs in recovery from SUD in the United States experience challenges when attempting to return to work following treatment for SUD for reasons yet to be identified. The purpose of this qualitative multiple-case study was to explore the …
How Inflammation, High-Density Lipoproteins, And Genes Affect The Relationship Between Apol1 And Kidney Outcomes, Ninad S. Chaudhary
How Inflammation, High-Density Lipoproteins, And Genes Affect The Relationship Between Apol1 And Kidney Outcomes, Ninad S. Chaudhary
All ETDs from UAB
Over the past decade, the discovery of novel genetic loci on chromosome 22q, apolipoprotein-L1 (APOL1), has given insights into the racial differences in kidney outcomes at the population level. APOL1 risk alleles are unique to African ancestry and confer increased susceptibility to end-stage kidney disease (ESKD) especially among individuals without diabetes. However, the diseases do not occur in all who inherit these alleles. Current efforts are driven towards identifying the factors that can interact with APOL1 in the development of kidney diseases. This dissertation investigated whether the association between APOL1 and kidney outcomes is affected by inflammatory markers (AIM1), high-density …
The Role Of Pim3 Kinase In Promoting Tumorigenesis, Tumor Metastasis, And Cancer Cell Stemness In Human Hepatoblastoma, Raoud Marayati
The Role Of Pim3 Kinase In Promoting Tumorigenesis, Tumor Metastasis, And Cancer Cell Stemness In Human Hepatoblastoma, Raoud Marayati
All ETDs from UAB
Hepatoblastoma is the most common primary liver tumor in children. Despite an increasing incidence and major advances in care for other pediatric solid tumors, therapy for hepatoblastoma has remained virtually unchanged for the last 20 years, and children with metastatic or relapsed disease continue to suffer from a dismal prognosis. Treatment strategies primarily rely on cisplatin, due to its role as the most active single agent in hepatoblastoma treatment. However, chemoresistance remains a significant challenge with 54-80% of patients developing resistance to chemotherapy after 4-5 cycles of treatment. We have previously demonstrated that Proviral Integration site in Maloney murine leukemia …
Dopamine-Dependent Transcriptional Dynamics In Striatal Physiology And Cocaine Reward, Morgan Elizabeth Zipperly
Dopamine-Dependent Transcriptional Dynamics In Striatal Physiology And Cocaine Reward, Morgan Elizabeth Zipperly
All ETDs from UAB
Exposure to drugs of abuse alters transcriptional programs and neuronal activity, leading to long-lasting cellular and behavioral adaptations that may contribute to addiction. The nucleus accumbens (NAc), part of the mesocorticolimbic dopamine pathway, plays a central role in motivation, reward, and reward-related learning, and this brain region is highly implicated in the development and maintenance of addiction. However, the specific contributions of defined cell populations in the NAc to drug reward processes is still poorly understood. Here, we used electrophysiological, optogenetic, and single-nucleus RNA-sequencing (snRNA-seq) approaches in a rodent model system to define the acute physiological and transcriptional responses of …
Clinical Evaluation Of The Temporomandibular Joint Function Using 4d Jaw Tracking Following Total Joint Replacement, Farhana Rahman
Clinical Evaluation Of The Temporomandibular Joint Function Using 4d Jaw Tracking Following Total Joint Replacement, Farhana Rahman
All ETDs from UAB
The degenerative temporomandibular joint diseases such as osteoarthritis, rheumatic arthritis, TMJ ankylosis, condylar resorption is successfully treated by total joint replacement. The aim of this study was to examine the function of Temporomandibular joint after total joint replacement. 15 patients with unilateral or bilateral TMJ total joint replacements and 15 healthy controls were evaluated via SICAT JMT+ device. This non-invasive system measures 3D position and rotation in all degrees of freedom and allows undisturbed functional mandibular movements to provide a quantitative evaluation. In addition, a TMJ questionnaire consisting the subjective symptoms was also obtained. Mandibular movements after total joint replacements …