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Articles 421 - 450 of 2525
Full-Text Articles in Medicine and Health Sciences
An Evaluation Of The Impact Of Medical Home Structures And Care Processes On Temporary Profile Days Among Active-Duty U.S. Army Soldiers, Tanekkia M. Taylor-Clark
An Evaluation Of The Impact Of Medical Home Structures And Care Processes On Temporary Profile Days Among Active-Duty U.S. Army Soldiers, Tanekkia M. Taylor-Clark
All ETDs from UAB
Readiness, the Armed Forces’ ability to carry out a range of military operations, is one of the U.S. Army’s highest strategic priorities. The medical readiness of soldiers is a critical component of overall operational readiness. The greatest threat to medical readiness is acute musculoskeletal injuries (MSIs). Medical providers place soldiers on medical limitations referred to as a “temporary profile” to facilitate treatment and recovery of acute MSIs. Poorly managed temporary profiles negatively impact soldiers’ work attendance and performance, leading to the loss or limitation of over 25 million training/duty days annually. Changes within the primary care setting, including implementing the …
Is There A Relationship Between Leadership Characteristics And Services Provided Among Ihs Urban Indian Health Programs?, George Grant Tribble
Is There A Relationship Between Leadership Characteristics And Services Provided Among Ihs Urban Indian Health Programs?, George Grant Tribble
All ETDs from UAB
IS THERE A RELATIONSHIP BETWEEN LEADERSHIP CHARACTERISTICS AND SERVICES PROVIDED AMONG IHS URBAN INDIAN HEALTH PROGRAMS?GEORGE G. TRIBBLE HEALTHCARE LEADERSHIP ABSTRACT The Native American population has faced and been impacted by a wide range of actions throughout the last few hundred years. The loss of cultural norms and way of life continues to manifest itself through various socioeconomic concerns. At the center of the Native American leadership model is a disciplined and culturally specific guidance structure. The Urban Indian Health Program (UIHP) was created by the Indian Health Service to establish a culturally appropriate health care delivery model for Native …
Color Vision Testing With Readily Available Materials, Angel Perez
Color Vision Testing With Readily Available Materials, Angel Perez
All ETDs from UAB
COLOR VISION TESTING WITH READILY AVAILABLE MATERIALS ANGEL PEREZ VISION SCIENCE ABSTRACT The perception of color is a process by which the brain discriminates different light wavelengths stimulating the cone photoreceptors in the retina of the eye. In humans each cone contains a photopigment making it most sensitive to either short (red), medium (green), or long (blue) wavelengths of light. However, when one of the cone pigments is defective or missing, color discrimination is reduced, resulting in color vision deficiency due to a deficient sex-linked chromosome in most cases. Color vision deficiency has the potential to impede many everyday activities, …
Disrupting The Perioperative Opioid Gateway: Identification Of Risk Factors For New Persistent Post-Surgical Opioid Use, Gia Marie Pittet
Disrupting The Perioperative Opioid Gateway: Identification Of Risk Factors For New Persistent Post-Surgical Opioid Use, Gia Marie Pittet
All ETDs from UAB
A large portion of the American Opioid Crisis is due to opioid naïve patients who become new persistent post-surgical opioid users, although the risk factors for the development of this addiction are not well studied. The objective of this study was to analyze multiple layers of pre-operative and procedural risk factors using an ecological perspective theoretical framework in adult patients undergoing invasive surgery. We performed a retrospective analysis of 13,970 opioid naïve adults in a mixed surgical cohort with data available at the University of California Los Angeles that was merged with narcotics data for the State of California (IRB#19-000625). …
Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel
Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel
All ETDs from UAB
Drug persistence is one of the major impediments for cancer therapeutics. There are two known evolutionary models for tumor drug persistence. First, a pre-existing sub-population is inherently resistant to treatment; and second, a sub-population acquires resistance by drug-induced molecular reprograming. One ideal model to study the mechanism of drug persistence is chronic myeloid leukemia (CML), a hematopoietic stem cell (HSC) disorder. HSCs acquire a single translocation between chromosome 9 and 22, forming BCR-ABL, a constitutively active tyrosine kinase. Tyrosine kinase inhibitors (TKI), the standard regimen, have been able to efficaciously control CML and yet many patients relapse upon treatment discontinuation …
Evaluation Of Antimicrobial Effect Of Licorice Extrcat Agiasnt Oral Microorganisms, Roshanak Rastegar
Evaluation Of Antimicrobial Effect Of Licorice Extrcat Agiasnt Oral Microorganisms, Roshanak Rastegar
All ETDs from UAB
Introduction: The causative factors of dental caries have been studied for many years, however, preventing the formation of dental caries remains an elusive task. Microorganisms have been the focal point of numerous studies as a prime cariogenic factor. Streptococcus mutans and Candida albicans have been frequently co-isolated from dental biofilm in patients with early childhood caries (ECC) and studies have demonstrated the synergistic effects of these two microorganisms in promoting tooth demineralization. Acid and glucan production, which are two virulence factors produced by S. mutans that mediate biofilm formation and tooth decay, have been shown to be promoted during co-colonization …
The Psychological, Social, And Bioinformatic Considerations For The Return Of Continental Genetic Ancestry Estimates And Other Secondary Sequencing Results, Jaimie Leighan Richards
The Psychological, Social, And Bioinformatic Considerations For The Return Of Continental Genetic Ancestry Estimates And Other Secondary Sequencing Results, Jaimie Leighan Richards
All ETDs from UAB
With recent advances in sequencing technologies, large scale genome wide sequencing has advanced our understanding of disease risk and etiology. These tests, however, often provide secondary data beyond the scope of the original sequencing objectives, and our understanding of how and if participants want to receive these secondary results is important as clinical and research-based sequencing becomes commonplace. To address this, we completed a systematic review of quantitative research that measures attitudes and preferences on the return of genomic sequencing results. Based on that review, we studied the return of genetic ancestry since these results, popularized in direct-to-consumer sequencing companies …
Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson
Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson
All ETDs from UAB
Cancer is a complex disease characterized by uncontrolled growth of transformed cells that can arise in many tissue types throughout the body (e.g., breast, lung, prostate, pancreas, lymph nodes) and is a major cause of death worldwide. Cancer progression resulting in aggressive or metastatic disease accounts for one of the leading causes of death worldwide, second only to heart disease in the US. Incidentally, cancer-related mortality has been on a steady decline, dropping 25% over the last 25 years [1]. This could be attributed to improved and earlier diagnoses and better treatment options being developed over the past few decades. …
Pain-Related Injustice Appraisal And Chronic Low Back Pain Among Arabs In The United States, Albatool Homoud Alnojeidi
Pain-Related Injustice Appraisal And Chronic Low Back Pain Among Arabs In The United States, Albatool Homoud Alnojeidi
All ETDs from UAB
Pain-related injustice appraisal has emerged as a psychosocial predictor of deleterious chronic low back pain (CLBP) outcomes. The appraisal is defined as the individual’s perception regarding the magnitude and irreparability of pain-related loss and suffering, externalized blame, and unfairness. Research in diverse samples revealed racial differences in pain-related injustice appraisal, suggesting that it may reflect broader racial/ethnic, sociocultural, and socioeconomic factors. This agrees with theories recognizing the role of ethnic and cultural characteristics in ethnic minorities’ health. Despite global data showing that Arabs represent the population with the second-highest prevalence of CLBP worldwide, a reliable characterization of CLBP among Arabs …
Suppressing Islet Graft Rejection With Antioxidant-Based Encapsulation Materials, Jessie Marie Barra
Suppressing Islet Graft Rejection With Antioxidant-Based Encapsulation Materials, Jessie Marie Barra
All ETDs from UAB
A hallmark of Type 1 diabetes (T1D) is the autoimmune destruction of insulin-producing pancreatic β-cells. Once the β-cells are lost, patients are reliant on less efficient exogenous insulin therapies to maintain glycemic control, leaving them at risk for secondary complications. Islet transplantation can restore the ability to regulate glucose levels without the need for exogenous insulin, however long-term islet graft survival has proven challenging in part due to ongoing immune-mediated destruction. Systemic immunosuppression strategies have proven somewhat effective at preventing rejection, but chronic use leaves the patient susceptible to opportunistic infections and organ toxicity. Reactive oxygen species (ROS), such as …
Applications Of Longitudinal Machine Learning Methods In Multi-Study Alzheimer's Disease Datasets, Charles F. Murchison
Applications Of Longitudinal Machine Learning Methods In Multi-Study Alzheimer's Disease Datasets, Charles F. Murchison
All ETDs from UAB
Advances in statistical learning models for prediction have led to broader application across a variety of disciplines, granting generalizations and adaptations that were previ-ously intractable even with advanced computational techniques. Among these is the al-lowance of correlated data with inherent paneled structure such as longitudinal or clus-tered data; adjustments which have already begun to be applied to a variety of supervised and unsupervised machine learning methods which had previously focused on cross-sec-tional data. These modifications have seen rudimentary testing in a number of applied disciplines where correlated data is commonly observed, including medical and clinical research. One field in particular …
Neonatal Murine Cytomegalovirus Infection Disrupts Synapse Remodeling During Development, Jerome Moulden
Neonatal Murine Cytomegalovirus Infection Disrupts Synapse Remodeling During Development, Jerome Moulden
All ETDs from UAB
Human cytomegalovirus (HCMV) is a complex double stranded DNA betaherpesvirus. Its linear DNA in enclosed in an icosahedral capsid, and has a genome size of about 230kb and encodes about 170 genes. Primary infection with HCMV lead to a lifelong persistent infection. HCMV can also be transmitted across the placenta and infect the developing fetus leading to infection of the newborn infant, an infection which is commonly described as congenital HCMV infection. In the United States, the prevalence of congenital HCMV infection is between 0.2-1.2%. Approximately 5-15% of these newborn infants will develop long-term neurological damage resulting, motor disorder, cognition …
Identifying Factors To Inform The Development Of Adaptive Interventions For Increasing Physical Activity Behavior Among People With Multiple Schlerosis, Yumi Kim
All ETDs from UAB
People with multiple sclerosis (MS) can benefit from physical activity, specifically exercise, for the management of disease symptoms, including walking impairments, fatigue, and depression, and improvements in quality of life. However, people with MS do not engage in adequate amounts of physical activity for the accrual of health benefits. Researchers have focused on the delivery of exercise training and behavioral interventions to improve levels of physical activity in MS. To date, there is an emerging body of research supporting the efficacy of these interventions for increasing and potentially sustaining physical activity behavior in people with MS. Yet, people with MS …
Multidrug-Resistance, Antibiotic-Associated Acute Kidney Injury, And Poor Disease Prognosis In Community-Acquired Bacterial Pneumonia, Adeniyi J. Idigo
Multidrug-Resistance, Antibiotic-Associated Acute Kidney Injury, And Poor Disease Prognosis In Community-Acquired Bacterial Pneumonia, Adeniyi J. Idigo
All ETDs from UAB
In this dissertation research, I examined the challenges of treating patients with bacterial community-acquired pneumonia (CAP) with the purpose of identifying risk factors linked with multidrug-resistant (MDR) Pseudomonas, treatment toxicity, and poor disease prognosis. I used a retrospective cohort study design to explore a clinical cohort of patients admitted to the University of Alabama at Birmingham hospital network who had bacterial pneumonia diagnosis assessed to be from community transmission between January 2013-December 2019. Electronic medical records were accessed for socio-demographic and clinical information. First, I examined the local prevalence/incidence of Pseudomonas CAP and MDR Pseudomonas CAP, and the relationship between …
Studies On Nontypeable Haemophilus Influenzae Biofilm Persistence & Redox Homeostasis In Chronic Bacterial Diseases, Benjamin C. Hunt
Studies On Nontypeable Haemophilus Influenzae Biofilm Persistence & Redox Homeostasis In Chronic Bacterial Diseases, Benjamin C. Hunt
All ETDs from UAB
Bacterial biofilms, or surface-adherent bacterial communities surrounded by a self-produced extracellular polymeric matrix, are ubiquitous. They are found throughout Earth’s ecosystems, in the soil and waterways, and more pressingly for the medical community, they are found within humans. Bacterial biofilms are associated with a multitude of diseases and their involvement significantly complicates treatment given that bacteria growing within a biofilm are extremely more resistant to antibiotics and immune effectors. Thus, the need to better understand biofilm biology and find ways to disrupt and/or sensitize biofilms to medical treatment is significant. The goal of the research presented herein was to investigate …
Diurnal Variation In Hippocampal Neurophysiology And Pathophysiology, Allison R. Fusilier
Diurnal Variation In Hippocampal Neurophysiology And Pathophysiology, Allison R. Fusilier
All ETDs from UAB
Circadian rhythms are ~24-hour cycles in biological processes that are endogenously generated, entrained to light, and synchronized by the suprachiasmatic nucleus of the hypothalamus. One process that is influenced by circadian rhythms is cognitive function, which varies over the course of the day and is likely influenced by changes in neuronal physiology over the course of the day. Dysfunction in circadian rhythms has been documented in many diseases, including Alzheimer’s disease (AD). AD is a neurodegenerative disease most notably characterized by dementia, amyloid beta plaques, and tau tangles. There is currently no cure for AD, and treatments only slow disease …
Tau-Sh3 Interactions And Alzheimer's Disease, Jonathan Roth
Tau-Sh3 Interactions And Alzheimer's Disease, Jonathan Roth
All ETDs from UAB
Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide, and its impact will increase with an aging population. It is characterized by dementia associated with accumulation of extracellular amyloid-β (Aβ) plaques, intracellular hyperphosphorylated Tau tangles, and neurodegeneration. Additionally, network hyperexcitability occurs early in AD and likely contributes to disease pathogenesis. Current therapies provide minor delay of disease progression at best, so it is imperative to develop novel therapeutic approaches to prevent and treat AD. As Tau pathology correlates better with cognitive function than Aβ pathology and Tau reduction prevents Aβ-induced dysfunction in preclinical models, targeting Tau is a growing …
Patterns Of Medication Adherence In Glaucoma, Shervonne Poleon
Patterns Of Medication Adherence In Glaucoma, Shervonne Poleon
All ETDs from UAB
Over 60 million persons globally are affected by primary open angle glaucoma (POAG)—an optic neuropathy characterized by distinctive patterns of vision loss. Glaucoma is a leading cause of irreversible blindness worldwide, and eye drops that delay vision loss are a common treatment modality. In glaucoma, the proportion of patients with good adherence to recommended therapy is reported to be low. High treatment cost, forgetfulness, and regimen complexity have been identified as key determinants of poor adherence. However, addressing these factors in the clinic is not as simple, as patient and provider values and priorities may differ. Without concordance, it can …
Glycoprotein 340 Expression In Dry Eye Disease And Ocular Surface Infection, Kwaku Antwi Osei
Glycoprotein 340 Expression In Dry Eye Disease And Ocular Surface Infection, Kwaku Antwi Osei
All ETDs from UAB
Glycoprotein 340 (Gp340) is a 340-kDa multi-domain pattern recognition receptor (PRR) belonging to the scavenger receptor cysteine-rich superfamily of proteins. On the ocular surface, Gp340 is expressed in the tear film, lacrimal gland, cornea, and conjunctiva. By their nature, PRRs detect pathogen-associated molecular patterns (PAMPs) on microbial organisms and damage-associated molecular patterns (DAMPs) released from injured, stressed, necrotic, and apoptotic cells. This, in turn, induces the expression of nuclear factor-κB- and the interferon regulatory factor-dependent expression proinflammatory cytokines and chemokines, eliciting both innate and adaptive immune response activation. Thus, as a PRR, Gp340 has the potential to modulate microbial infection …
Role Of Partnership In Hiv-Related Outcomes In Heterosexual Individuals Newly Diagnosed With Hiv, Maira Sohail
Role Of Partnership In Hiv-Related Outcomes In Heterosexual Individuals Newly Diagnosed With Hiv, Maira Sohail
All ETDs from UAB
A supportive intimate partner has shown to be helpful in HIV care of men who have sex with men, and in some African heterosexual couples; however, knowledge on this phenomenon among heterosexual people with HIV (PWH) is limited in the United States context. This project included two quantitative studies and one qualitative study to examine the role of intimate partnership in HIV care among heterosexual, newly diagnosed PWH. Both quantitative studies were conducted among heterosexual, newly diagnosed (2013-2017) individuals at the University of Alabama at Birmingham (UAB) 1917 Clinic. The first study examined the role of partnership (un-partnered, unmarried-partnered, and …
Effeccts Of Hiv-1 Tat On Tspo, A Biomarker Of Neuroinflammation, Nguyen Thuy Nhu Nguyen
Effeccts Of Hiv-1 Tat On Tspo, A Biomarker Of Neuroinflammation, Nguyen Thuy Nhu Nguyen
All ETDs from UAB
HIV-associated neurocognitive disorders (HAND) produces serious neurological dysfunction for > 50% of people living with HIV (PLWH). As antiretroviral therapy (ART) has transformed HIV into a chronic disease, and since most ART does not effectively cross the blood brain barrier, HAND is predicted to further increase in prevalence in PLWH. The HIV-Trans-Activator of Transcription (Tat) is known to persist in the central nervous system (CNS) of chronically infected HIV+ individuals. In several preclinical studies, HIV-Tat has been shown to be neurotoxic and important for HIV pathogenesis. Translocator protein (TSPO), an 18 kDa mitochondrial protein, has been shown to be increased via …
Characterization Of Rna Polymerase I Trigger Loop Mutations, Collin Ainslie
Characterization Of Rna Polymerase I Trigger Loop Mutations, Collin Ainslie
All ETDs from UAB
RNA polymerases are primarily multi-subunit enzymes that synthesize RNAs from template DNA strands. RNA polymerase I (Pol I) is the eukaryotic RNA polymerase that synthesizes the majority of ribosomal RNA (rRNA) for ribosome production. These include the 5.8S, 28S, and 18S rRNAs which are synthesized from a polycistronic gene in the nucleolus. The rRNAs synthesized by Pol I, the 5S rRNA, & ribosomal proteins come together to synthesize ribosomes through ribosome biogenesis. Dysregulation of Pol I activity has been established to contribute to dysregulation of ribosome biogenesis and disease state development. These conditions include but are not limited to Cincinnati …
Characterization Of Cellular And Viral Factors That Define The Stability Of The Latent Hiv-1 Reservoir, Eric Carlin
Characterization Of Cellular And Viral Factors That Define The Stability Of The Latent Hiv-1 Reservoir, Eric Carlin
All ETDs from UAB
Human immunodeficiency virus (HIV) infection is a chronic viral illness that requires lifelong management due to the early formation of a latent viral reservoir within the patient’s CD4+ T cells. These latent infection events lay dormant within infected cells and reactivate stochastically or during periods of T cell activation presenting a major hurdle to the development of an HIV cure. As our understanding of the factors that contribute to HIV latency has evolved, we have started to appreciate latency as more than a chromatin regulation phenotype, due to the vast number of cellular factors that have been described to impact …
Tgfβ Provides The Backbone Of Embryogenesis: Elucidating The Role Of Tgfβ Signaling And Its Downstream Effectors On Spinal Column Development, Sade Williams Clayton
Tgfβ Provides The Backbone Of Embryogenesis: Elucidating The Role Of Tgfβ Signaling And Its Downstream Effectors On Spinal Column Development, Sade Williams Clayton
All ETDs from UAB
The spinal column is composed of two components, the vertebra (VB) that provide support and the intervertebral disc (IVD) that provide weight distribution. The structural integrity of IVDs is maintained by a fibrocartilaginous tissue called the annulus fibrosus (AF) which can degenerate with age or trauma and contribute to chronic back pain. There are currently no diseases modifying treatments that curb IVD degeneration. Regenerative therapies to treat IVD degeneration can be developed from identifying the signaling factors required for AF differentiation, but these factors are unknown. Previously, we showed that TGFβ signaling is required for AF formation in mice and …
Implications Of Day-To-Day Oulsatility Index Change And Corticosteroid Use In Pediatric Traumatic Brain Injury, Jeremy D. Jordan
Implications Of Day-To-Day Oulsatility Index Change And Corticosteroid Use In Pediatric Traumatic Brain Injury, Jeremy D. Jordan
All ETDs from UAB
A traumatic brain injury (TBI) is a disruption of the normal function and structure of the brain after a direct or indirect injury. In children, TBI continues to be a significant cause of mortality resulting in the death of over 20 children per day in the United States (Reuter-Rice et al., 2015). Additionally, children who survive TBI have increased rates developmental delay, physical disabilities, neurologic impairment, and mental health disorders (Barlow et al., 2005). A TBI occurs in two phases. The primary injury is the physical insult to the brain that occurs at the time of the injury. The secondary …
Glycolytic Myeloid Cells Protect The Host In Tuberculosis, Hayden Thomas Pacl
Glycolytic Myeloid Cells Protect The Host In Tuberculosis, Hayden Thomas Pacl
All ETDs from UAB
Despite curative treatment, tuberculosis remains a leading cause of death around the world. As such, there is great interest in novel therapeutic approaches to treat this disease. One such approach aims to enhance the efficacy of host immune cells in responding to the pathogen, Mycobacterium tuberculosis—so called host-directed therapies. The metabolism of immune cells has been a central focus in the search for hostdirected therapies, and the role of glycolysis in myeloid cells, in particular, has received much attention. However, the role of glycolysis in myeloid cells in the context of tuberculosis has not yet been made clear. Here we …
Combining Meg And Fmri To Examine Dynamic Task-Related Brain Activity With High Spatio-Temporal Resolution, Sangeeta Nair
Combining Meg And Fmri To Examine Dynamic Task-Related Brain Activity With High Spatio-Temporal Resolution, Sangeeta Nair
All ETDs from UAB
The characterization of brain networks contributing to healthy learning and memory can inform abnormalities and treatment approaches among clinical populations. A recent shift from lesion-based to network-based approaches of studying healthy and atypical brain development highlights the need for a more comprehensive understanding across spatiotemporal domains, particularly in the case of high-level cognitive processes. Both, associative learning and working memory involve distributed and interconnected networks of specialized brain regions. Dynamic communication within- and betweensuch systems are unable to be fully resolved by individual non-invasive imaging techniques such as fMRI or MEG. While fMRI serves as an ideal tool to investigate …
A Role For Inf-Ɣ-Inducble Transcription Factors In Antibody Secreting Cell Differentiation, Jessica N. Peel
A Role For Inf-Ɣ-Inducble Transcription Factors In Antibody Secreting Cell Differentiation, Jessica N. Peel
All ETDs from UAB
Viral infections remain a major cause of morbidity and mortality. Within a viral, interferon (IFN)-ɣ-driven inflammatory microenvironment, B cells may produce antibody which is critical for rapid viral clearance and continued protection from reinfection. However, the roles of IFN-ɣ and IFN-ɣ-induced transcription factors (TFs) in driving antibody secreting cell (ASC) development from their B cell precursors are poorly understood. Herein, we identify two IFN-ɣ-inducible transcription factors (TFs), T-bet and interferon regulatory factor 1 (IRF1), that are essential for the differentiation of ASCs from IFN-g-activated B cell precursors. T-bet repressed an IFN-ɣ-inducible inflammatory gene program that was incompatible with ASC formation …
Understanding The Role Of Biomechanics In Ovarian Cancer Biology, Alba Martinez Diaz
Understanding The Role Of Biomechanics In Ovarian Cancer Biology, Alba Martinez Diaz
All ETDs from UAB
Mechanical forces including compression, tension, and shear stress are increasingly implicated as instigators of tumor progression. Understanding how mechanobiology drives ovarian cancer is critical to identifying potential therapies. The effect of shear stress is beginning to be studied in ovarian cancer due to the presence of ascites in the peritoneal cavity that prompts tumor cells detachment and implantation in secondary sites. Therefore, mechanical cues are present within the peritoneal cavity. A growing ovarian tumor mass also experiences compressive and tensile forces, although their participation in tumor progression still remains unclear. Additionally, there is a specific lack of incorporation of mechanobiology …
The Assessment Of Neuro-Mechanics Of Inspiratory Muscles During Mechanical Ventilation, Hassan Y. Abunurah
The Assessment Of Neuro-Mechanics Of Inspiratory Muscles During Mechanical Ventilation, Hassan Y. Abunurah
All ETDs from UAB
The decline in inspiratory muscles function for patients undergoing mechanical ventilation may further extend the duration of mechanical ventilation leading to lethal complications. Thus, the assessment of neuro-mechanics of inspiratory muscles may help us understand the pathophysiology for mechanical ventilation failure to avoid its complications. In this dissertation, we assessed the characteristics of inspiratory neuromechanics under different conditions. This dissertation is reported in three different papers. In the first paper, we sought to assess the quality of the available literate that used surface EMG of extra-diaphragmatic muscles during invasive mechanical ventilation. We demonstrated that the use of sEMG of extra-diaphragmatic …