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All ETDs from UAB

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Articles 1951 - 1980 of 2525

Full-Text Articles in Medicine and Health Sciences

Perioperative Music And Its Effects On Anxiety, Hemodynamics, And Pain In Women Undergoing Mastectomy, Pamela Gail Binns-Turner Jan 2008

Perioperative Music And Its Effects On Anxiety, Hemodynamics, And Pain In Women Undergoing Mastectomy, Pamela Gail Binns-Turner

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The study purpose was to examine the effects of a perioperative music intervention on changes in mean arterial pressure (MAP), heart rate (HR), anxiety, and pain in women with a diagnosis of breast cancer undergoing mastectomy surgery. The convenience sample included 30 women between the ages of 42 and 70 who were undergoing mastectomy in a large urban hospital in the southern United States. Exclusion criteria included male gender, psychiatric disorder, use of psychotropic medications, cognitive mental disability, and American Society of Anesthesiologists (ASA) status 4 or greater. In a quasiexperimental, repeated measures design, participants were randomized equally into music …

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Evaluation Of Pre And Post Treatment Filtration Performance Of Kinetico Macrolite® Ceramic Media Compared To Traditional Sand/Anthracite And Gac Filters In Drinking Water Treatment Process, Jeff Cochran Jan 2008

Evaluation Of Pre And Post Treatment Filtration Performance Of Kinetico Macrolite® Ceramic Media Compared To Traditional Sand/Anthracite And Gac Filters In Drinking Water Treatment Process, Jeff Cochran

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This study was conducted in conjunction with the Birmingham Water Works Board to evaluate Kinetico ceramic filter media against GAC (Granular Activated Carbon) and Sand/Anthracite filters. The Birmingham Water Works Board Water Treatment Pilot Plant was located and operated on the Shades Mountain Filter Plant (SMFP) premises. The evaluation was conducted in three phases: plant matching, plant optimization, and pre-filter testing. The initial phase called for determining the best combination of Kinetico Macrolite Ceramic media to match or outperform the existing Sand/Anthracite dual media filters located at SMFP. At the end of the testing it was determined that 18 inches …

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Analysis Of The Role Of Fcrl5 And Figlers In B Cell Development, Signaling, And Malignancy, Christopher L. Haga Jan 2008

Analysis Of The Role Of Fcrl5 And Figlers In B Cell Development, Signaling, And Malignancy, Christopher L. Haga

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The regulation of signaling and migration is critical to B lymphocyte development, activation, and proliferation. This dissertation reports a functional role for Fc receptor-like molecule 5 (FCRL5), a B cell specific member of the Fc receptor-like family of molecules, and the discovery of a novel family of conserved transmembrane proteins with fibronectin, immunoglobulin, and leucine-rich repeat domains (FIGLER) expressed in bone marrow and B lineage cells. Until now, the signaling potential of FCRL5 was unknown. A panel of FcRIIB/FCRL5 chimeric receptors were created and expressed in a B cell line lacking endogenous FcRIIB. Coligation of the chimeric receptor with the …

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Mechanism Of Interferon-Beta-Mediated Inhibition Of Il-8 Gene Expression, Travis Laver Jan 2008

Mechanism Of Interferon-Beta-Mediated Inhibition Of Il-8 Gene Expression, Travis Laver

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Interleukin-8 (IL-8) is a potent chemoattractant of numerous cells, particularly neutrophils, in the innate immune response. In addition to immune functions, IL-8 is known to contribute to the pathogenesis of a number of diseases, including cancer. Interferon-β (IFN-β), a Type I interferon, inhibits the expression of IL-8, but the details of this effect are not known. In this study we investigate transcriptional control of the IL- 8 gene and the mechanism by which IFN-β exerts inhibitory effects on IL-8. Herein we show that stimulation of U87-MG glioma cells with phorbol 12-myristate 13-acetate (PMA) results in a rapid recruitment of NF-κB …

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Air Pollution And Preterm Births In Atlanta, Georgia, Corey Masuca Jan 2008

Air Pollution And Preterm Births In Atlanta, Georgia, Corey Masuca

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Exposure to ambient outdoor air pollution exposure is one of the many extraneous factors associated with preterm births. Many epidemiological studies involving preterm births and ambient air pollution have repeatedly indicated positive associations. However, for many such studies, results may be statistically significant but weakly associated or inconclusive. Such results may be primarily attributable to the fact that most studies include only single or multiple criteria air pollutants but not the total air pollution mixture of criteria air pollutants and air toxic pollutants (e.g., PAHs) to which people are actually exposed. This study assessed associations between pollutant classes, including criteria …

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Multiracial Tobacco, Alcohol, And Drug Use: An Investigation Of The Function Of Racial Identity In A Longitudinal Sample From Youth To Young Adulthood, Julia Katrina Crumly Jan 2008

Multiracial Tobacco, Alcohol, And Drug Use: An Investigation Of The Function Of Racial Identity In A Longitudinal Sample From Youth To Young Adulthood, Julia Katrina Crumly

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The purpose of the research is threefold. The first purpose is to determine if multiracial individuals are at a higher risk for alcohol, tobacco, and drug use. The second purpose is to determine the relationship between racial identity and risk behaviors. The third purpose is to determine how the change/no change of racial identity longitudinally contributes to one’s risk to engage in risk behaviors. A national representative longitudinal data set was obtained and analyzed for the purpose of this study. Results of the study reveal that there are differences in multiracial groups for risk behaviors, minority identification is not necessarily …

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The Effects Of Maternal Prenatal Insults On The Bmi Growth Trajectory Of Children Between The Ages Of 5-12 Years, Anthony Goudie Jan 2008

The Effects Of Maternal Prenatal Insults On The Bmi Growth Trajectory Of Children Between The Ages Of 5-12 Years, Anthony Goudie

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The level of childhood obesity in the United States is at epidemic proportions. Most population studies looking at the factors contributing to childhood obesity focus on obesity as a dichotomous outcome. The purpose of this study is to test for the effects of maternal prenatal insult behaviors on the growth trajectory of a sample of children 5-12 years of age in the United States. This is the first known study to use a latent growth curve model and a cohort-concurrent analytical design to test the association between maternal prenatal insult behaviors and the annual longitudinal increase in body mass index …

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Growth Hormone Signaling And Action In Osteoblasts, Douglas J. Digirolamo Jan 2008

Growth Hormone Signaling And Action In Osteoblasts, Douglas J. Digirolamo

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Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) exert profound growth promoting actions during pre- and post-natal skeletal development. GH and IGF- 1 appear to cause these anabolic actions by influencing a variety of effects on osteoblast proliferation, differentiation, and survival. However, because GH stimulates the production of IGF-1 from the liver and other GH-responsive peripheral tissues, including bone, the individual contributions of these two molecules to anabolic responses in bone remains poorly defined. In this dissertation research, I sought to distinguish the direct and indirect (IGF-1 dependent) GH actions on osteoblasts. In the first section of this thesis, I …

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Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt Jan 2008

Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt

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Asthma is identified by the clinical symptoms of wheezing, chest tightness, dyspnea and cough, and by the presence of airway hyperresponsiveness (AHR) to inhaled stimuli. We have reported previously that repeated bouts of moderate intensity aerobic exercise attenuate airway inflammatory responses in a mouse model of atopic asthma. Because the effects of exercise on physiological responses are dependent upon several variables, including total exercise duration, the hypothesis of the current work was that differing amounts of moderate intensity aerobic exercise exert dissimilar effects on AHR and airway inflammation. The aims to test this hypothesis included: 1) determine the effect of …

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Molecular Regulation Of Pax5-Mediated Biological Functions, Ti He Jan 2008

Molecular Regulation Of Pax5-Mediated Biological Functions, Ti He

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B lineage cells are major players in the adaptive immune system. Pax5 is essential for B lineage cell development and function. Pax5 controls B lineage cell developmental progression by regulating expression of many B lineage specific genes and the B lineage specific VH to DJH recombination; and the meantime, Pax5 also represses the transcription of lineage- and developmental stage- inappropriate genes to restrict the B lineage developmental pathway. It is not clear how Pax5-mediated function can be regulated to fulfill its role in different biological reactions. In this dissertation, we focused on the study of the molecular regulation of Pax5-mediated …

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Biogenesis, Trafficing, And Function Of Wild-Type And Mutant Cystic Fibrosis Transmembrane Conductance Regulator (Cftr), Asta Jurkuvenaite Jan 2008

Biogenesis, Trafficing, And Function Of Wild-Type And Mutant Cystic Fibrosis Transmembrane Conductance Regulator (Cftr), Asta Jurkuvenaite

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Cystic fibrosis (CF) is a genetic disease resulting from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel that functions at the apical surface of epithelial cells and plays a critical role in mucociliary clearance. The most common mutation in the CFTR gene involves a deletion of phenylalanine at position 508 in the protein (ΔF508 CFTR). ΔF508 CFTR is recognized as misfolded in the endoplasmic reticulum (ER) and is degraded. In vitro manipulations such as culturing cells at 27°C can “rescue” ΔF508 CFTR to the plasma membrane (rΔF508 CFTR), but no pharmacological agent has produced comparable …

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Wavelet-Based Regression And Classification For Longitudinal Diffusion Tensor Imaging Data, William R. Prucka Jan 2008

Wavelet-Based Regression And Classification For Longitudinal Diffusion Tensor Imaging Data, William R. Prucka

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Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique capable of in vivo characterization of the spatial and angular dependence of free water diffusion in tissue. By studying intra- and extra-cellular water mobility, inference can be made about the surrounding medium. The non-uniform angular dependence of diffusion, known as anisotropy, is evident in fibrous tissues, which exhibit greater diffusion parallel versus perpendicular to the fiber orientation. DTI’s sensitivity to anisotropy makes it an effective tool for measuring the integrity of fibrous myelinated white matter tracts in the brain. For demyelinating diseases such as multiple sclerosis (MS), DTI has …

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The Role Of Ddx3 In Regulating Apoptosis, P53 And Snail, Mianen Sun Jan 2008

The Role Of Ddx3 In Regulating Apoptosis, P53 And Snail, Mianen Sun

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Cancer is a common disease that causes high rates of lethality. Resistance to cancer therapy is one major obstacle for producing an effective cancer treatment. Clarifying mechanisms of cancer development, such as resistance to apoptosis and metastasis, can provide important information for developing effective cancer treatment strategies. In the present study, DDX3 was demonstrated to have effects on both responses to cancer treatment and cancer development. DDX3 together with glycogen synthase kinase-3 (GSK-3) was found to impede death receptor-induced apoptosis, which is important because death receptors are activated by some cancer treatments. Additionally, DDX3 was shown to regulate two proteins …

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Mapks Regulate Nuclear Import Of Human Papillomavirus Type 11 Replicative Helicase E1, Jei-Hwa Yu Jan 2008

Mapks Regulate Nuclear Import Of Human Papillomavirus Type 11 Replicative Helicase E1, Jei-Hwa Yu

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Papillomaviruses (PV) are prevalent pathogens that infect human or animal squamous epithelia. Its genome is a double strand circular DNA of approximately 7.9 kb. It contains origin of replication (ori) and encodes early viral proteins for viral DNA amplication, and late capsid proteins for packaging viron. The viral DNA replicates as extrachromosomal nuclear plasmid in the host cell. Infections by low risk virus, such as HPV-6 and -11, can result in benign papillomas, condylomata, and low grade squamous intraepithelial dysplasias (SIL), whereas infection by high risk virus, such as HPV-16 and -18, can progress to high grade SIL, carcinoma in …

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Potential Iatrogenic Effects On Enamel Treated With A Light Cured Flouride Releasing Filled Resin, Henry G. Griggs Jan 2008

Potential Iatrogenic Effects On Enamel Treated With A Light Cured Flouride Releasing Filled Resin, Henry G. Griggs

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White spot lesions have long been a problem in fixed appliance orthodontic treatment. Various methods of prevention have been used in the past, most requiring patient compliance. The use of non-compliant orthodontic sealants to form a barrier on the facial surface of the tooth has been attempted in the past with limited success due mainly to the inability of composite resins to fully polymerize. Pro Seal(Reliance Orthodontic Products, Inc, Itasca, IL) is new product which claims to fully polymerize and provide protection from white spot lesions during orthodontic treatment. In vitro studies support this claim. The side effects of acid …

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Effects Of Hexosamine Biosynthesis On An In Vitro Model Of Cardiacischemia, Voraratt Champattanachai Jan 2008

Effects Of Hexosamine Biosynthesis On An In Vitro Model Of Cardiacischemia, Voraratt Champattanachai

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Increased levels of protein O-linked-N-acetylglucosamine (O-GlcNAc) have been correlated with increased cell survival following stress. Therefore the goal of this study was to determine whether enhanced flux through the hexosamine biosynthesis pathway (HBP), which leads to elevated levels of O-GlcNAc, improved the tolerance of isolated neonatal rat ventricular myocytes (NRVMs) to ischemia/reperfusion (I/R) injury. NRVMs were exposed to hypoxic medium for 4 hours, followed by oxygenated complete medium for 16 hours. Acute treatment with 5 mM glucosamine showed an increase in viability and decreased both necrosis and apoptosis following I/R. Glucosamine increased O-GlcNAc levels maximally at 2 hours and went …

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The Relationship Of Medical Homeness To The Quality Of Life Of Mothers Of Children With And Without Special Health Care Needs, Cynthia G. Cortes Jan 2008

The Relationship Of Medical Homeness To The Quality Of Life Of Mothers Of Children With And Without Special Health Care Needs, Cynthia G. Cortes

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A cross-sectional study was conducted to investigate the relationship of child, family, and medical home status to quality of life for mothers of children with and without special health care needs. Mothers of children with (n=100) and without (n=80) special health care needs, completed a questionnaire at a children’s hospital in the southeastern United States focusing on the child, family, and medical home and maternal quality of life. Standardized instruments were used to measure quality of life (SF-36) and social support (Social Support Questionnaire). Non-standardized instruments used in other research were incorporated into the maternal questionnaire. Logistic and linear regression …

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Structural And Functional Properties Of Human Αa-Crystallin, Jose Mauro Chaves Jan 2008

Structural And Functional Properties Of Human Αa-Crystallin, Jose Mauro Chaves

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The three specific aims of the project were: (1) compare effects of deamidation alone (i.e., αA-N101D, αA-N123D, αA-N101/123D), truncation alone (αA-NT mutant [deletion of residue no. 1-63], or αA-CT mutant [deletion of residue no. 140-173]), or both truncation plus deamidation on structural and functional properties of human lens αA-crystallin; (2) identify components of complexes in the water soluble-high molecular weight (WS-HMW) proteins of normal aging and cataractous human lenses; and (3) determine interactions among WT-αA, αA-NT and αA-CT crystallin species with filensin and phakinin (beaded filament proteins) in vitro. The comparative structural and functional differences between αA-deamidated and/or truncated mutants …

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Microbial Biofilm Attachment To Caenorhabditis Elegans, Kevin Drace Jan 2008

Microbial Biofilm Attachment To Caenorhabditis Elegans, Kevin Drace

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The closely related bacterial species Xenorhabdus nematophila, Yersinia pestis and Y. pseudotuberculosis make biofilms capable of adhering to the head of the model nematode Caenorhabditis elegans. Y. pestis uses biofilms to block the digestive tract of its vector, the flea, in order to enhance its efficiency of transmission. I investigated the role of biofilms in X. nematophila and found that, like its Yersinia sp. counterparts, production of biofilm requires a four-gene operon: hmsHFRS. X. nematophila is an insect pathogen and an obligate symbiont of the nematode Steinernema carpocapsae. However, an X. nematophila hmsH mutant that failed to make biofilms on …

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Role Of The Gm/Gn Glycoprotein Complex In The Final Assembly And Egress Of The Human Cytomegalovirus (Hcmv), Magdalena Anna Krzyzaniak Jan 2008

Role Of The Gm/Gn Glycoprotein Complex In The Final Assembly And Egress Of The Human Cytomegalovirus (Hcmv), Magdalena Anna Krzyzaniak

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HCMV consists of a dsDNA genome enclosed by, an icosahedral capsid surrounded by a layer of tegument proteins; the virion structure is enclosed in a lipid envelope rich in virus expressed glycoproteins. The HCMV envelope contains an incompletely defined number of glycoproteins. The glycoprotein M (gM) and glycoprotein N (gN) form a gM/gN protein complex which is the most abundant protein component of the HCMV envelope. Recent studies have indicated that deletion of the viral gene encoding either gM or gN is lethal for HCMV. The gM C-terminal cytoplasmic tail (gM-CT) revealed an acidic cluster and a tyrosine-based trafficking motifs. …

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Punctal Occlusion Impact On Tear Film Immuno-Regulatory Proteins Measured By Cytometric Bead-Based Assay, Martin W. Lafrance Jan 2008

Punctal Occlusion Impact On Tear Film Immuno-Regulatory Proteins Measured By Cytometric Bead-Based Assay, Martin W. Lafrance

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PURPOSE: This study compares vendor reagents used for cytometric bead-based assay (CBA) of cytokines in human tears and validates a protocol for use in evaluating punctal occlusion, a treatment for keratoconjunctivitis sicca. It has been proposed that punctal occlusion may alter tear cytokine concentrations based on the facts that: (1) tear clearance, a measure of the balance between tear production and elimination, declines following occlusion and (2) reduced tear clearance and increased levels of pro-inflammatory tear cytokines are correlated in dry eye patients. This study compares tear clearance values and the level of 24 tear cytokines measured by CBA following …

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Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee Jan 2008

Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee

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Microglia/macrophages are the main intrinsic immune effector cells and the first cell types that respond to a variety of CNS injures. They have important functions including secretion of cytokines/chemokines and antigen presentation, thereby regulating immune responses. Interferon-γ (IFN-γ) is a cytokine involved in many aspects of the immune response, and activates microglia/macrophages to express cell surface antigens such as class II MHC, and co-stimulatory molecules such as CD40. CD40 and class II MHC molecules play a critical role in immune reactivity such as antigen presentation and subsequent T cell activation. However, aberrant CD40 and class II MHC expression have been …

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Interim Monitoring Efficacy, Safety And Futility In Phase Iii Clinical Trials, Qing Li Jan 2008

Interim Monitoring Efficacy, Safety And Futility In Phase Iii Clinical Trials, Qing Li

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Phase III trials often have both efficacy and safety outcomes. Sometimes the safety outcomes are closely associated with the efficacy outcomes. We sought to find a statistical method to treat both efficacy and safety outcomes as bivariate primary outcomes and set up stopping rules at interim stages based on the following criteria: (1) greater safety; (2) greater efficacy; (3) futility. We first examined the internal pilot design to adjust sample size for clinical trials with a bivariate response (efficacy and safety). Three nuisance parameters (two variances and correlation) need to be considered when doing sample size recalculation for the internal …

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The Au-Rich Element Mrna Decay-Promoting Activity Of Brf1 Is Regulated By Mitogen-Activated Protein Kinase Activated Protein Kinase 2, Sushmit Maitra Jan 2008

The Au-Rich Element Mrna Decay-Promoting Activity Of Brf1 Is Regulated By Mitogen-Activated Protein Kinase Activated Protein Kinase 2, Sushmit Maitra

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Regulated mRNA decay is a highly important process for the tight control of gene expression. Inherently unstable mRNAs contain AU-rich elements (AREs) in the 3’ untranslated regions that direct rapid mRNA decay by interaction with decay-promoting ARE-binding proteins (ARE-BPs). The decay of ARE-containing mRNAs is regulated by signaling pathways, which are believed to directly target ARE-BPs. Here, we show that BRF1 involved in ARE-mediated mRNA decay (AMD) is phosphorylated by MAPK-activated protein kinase 2, MK2. In vitro kinase assays using different BRF1 fragments suggest that MK2 phosphorylates BRF1 at four distinct sites, S54, S92, S203, and an unidentified site at …

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The Physical And Mental Health Of Spouse Caregivers In Dementia: Finding Meaning As A Mediator Of Burden, Susan M. Mclennon Jan 2008

The Physical And Mental Health Of Spouse Caregivers In Dementia: Finding Meaning As A Mediator Of Burden, Susan M. Mclennon

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The purpose of this study was to examine the effect of caregiver burden on the physical and mental health of caregivers of spouses with dementia and to determine if finding meaning through caregiving mediated the relationship between burden and health. This was a cross-sectional, correlational study in a convenience sample of 84 community-residing spouse caregivers of adults with dementia recruited from North- Central Florida. Measures included the Zarit Burden Interview, the Finding Meaning through Caregiving Scale, and the Medical Outcomes Short Form-36, version 2. Data analyses consisted of descriptive, correlational, and standard multiple regression statistical methods. The sample consisted of …

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Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore Jan 2008

Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore

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Overexpresssion of transforming growth factor (TGF)-β has been implicated in promoting immune suppression, tumor angiogenesis, tumor cell migration, and invasion in many cancers including carcinoma of the breast. Thus, targeted downregulation of TGF-β1 expression in breast cancer in situ and determination of its implications potentially could provide new treatment approaches for disease management. siRNA constructs targeting TGF-β1 were validated and used to develop clonal derivatives of the MDA-MB-435 metastatic breast cancer cell line. Inhibition of TGF-β1 expression in MDA-MB-435 cells showed decrease in migration and invasion in vitro with an increase in proliferation. In vivo analysis indicated a 90% decrease …

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The Role Of Centaurin Alpha-1 In The Regulation Of Neuron Al Differentiation, Carlene Drucilla Moore Jan 2008

The Role Of Centaurin Alpha-1 In The Regulation Of Neuron Al Differentiation, Carlene Drucilla Moore

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In the nervous system, PI 3-kinase has been implicated in neuronal differentiation. My studies have focused on a candidate neuronal PI 3-kinase target centaurin alpha-1, which binds PtdIns(3,4,5)P3, and is an Arf6 GAP. Centaurin alpha-1 is localized in dendrites, dendritic spines and synapses, and is required for neuronal differentiation and spine morphogenesis. In dissociated neuronal cultures, expression of centaurin alpha-1 enhances dendritic branching, and increases dendritic filopodia, lamellipodia and spine-like protrusions. Expression of centaurin alpha-1 GAP inactive mutant or knocking down centaurin alpha-1 levels using siRNA leads to inhibition of dendritic outgrowth and branching. Manipulations of centaurin alpha-1 also disrupt …

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Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols Jan 2008

Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols

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Overweight and obesity in school-aged children have become a major health issue. With overweight and obesity, children have increased risk of developing elevated blood pressure readings, glucose levels, and cortisol. Trait anger and patterns of anger expression have been shown to contribute to the elevations of blood pressure, glucose and cortisol in normoweight children and overweight adolescents. However, little research has been done with overweight school-aged children. The purpose of this study was to examine the relationships among trait anger and each of the patterns of anger expression (anger-suppression, anger-out, and anger-reflection/control) and blood pressure, glucose, and cortisol in overweight …

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Investigation Of Lipoteichoic Acid Structure And Function To Establish Its Role In Gram-Positive Bacterial Infections, Ho Seong Seo Jan 2008

Investigation Of Lipoteichoic Acid Structure And Function To Establish Its Role In Gram-Positive Bacterial Infections, Ho Seong Seo

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Lipoteichoic acid (LTA) is an essential bacterial membrane polysaccharide (cell wall component) that is linked to a glycerol backbone with two acyl chains. Since an antibody to LTA has been shown to protect from Gr+ bacterial infections or colonization, and the mutant Gr+ bacteria which produce less amount of LTA have less pathogenic than WT, LTA may be an important role in Gr+ bacterial infection and inflammation. The currently accepted structure of pneumococcal LTA has the pentameric repeating unit bound to the lipid anchor {Glc(β1��3)AATGal(β1��3)Glc(α1��3)-acyl2Gro}. Unlike the lipid anchor of other Gr+ bacterial LTA, this pneumococcal LTA lipid anchor has …

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An Exploration Of Factors Related To Hypertension Control In African American And Caucasian Municipal Employees, Sunun Sinsuesatkul Jan 2008

An Exploration Of Factors Related To Hypertension Control In African American And Caucasian Municipal Employees, Sunun Sinsuesatkul

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Hypertension is a major contributor to morbidity, mortality, and medical costs in the United States. African Americans (AAs) have the highest prevalence of hypertension in the world, exhibiting at least twice the rate for Caucasians in almost every age and sex group. AAs are also at higher risk for complications from hypertension than Caucasians. While several factors have been proposed as accounting for those differences, there is no consensus on which factors may be responsible; the reasons for disparities in hypertension control in AAs are complex, and need further investigation. This study explored relationships between multiple factors to identify how …

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