Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Doctor of Philosophy (PhD) Heersink School of Medicine (961)
- Doctor of Science in Nursing (DSN) School of Nursing (378)
- Doctor of Philosophy (PhD) School of Public Health (199)
- Doctor of Philosophy (PhD) School of Health Professions (153)
- Doctor of Public Health (DrPH) School of Public Health (127)
-
- Doctor of Philosophy (PhD) School of Nursing (121)
- Executive Doctor of Science (DSc) School of Health Professions (96)
- Master of Science (MS) School of Dentistry (89)
- Master of Science in Dentistry (MScD) School of Dentistry (62)
- Doctor of Philosophy (PhD) School of Optometry (58)
- Master of Dentistry (MDent) School of Dentistry (47)
- Obesity (41)
- Master of Science in Public Health (MSPH) School of Public Health (32)
- Mitochondria (31)
- Cancer (28)
- Master of Science (MS) School of Health Professions (27)
- Inflammation (26)
- HIV (25)
- Master of Science (MS) Heersink School of Medicine (25)
- Master of Science (MS) School of Public Health (21)
- African American (19)
- Aging (19)
- Epigenetics (19)
- Master of Science (MS) School of Optometry (19)
- Metabolism (19)
- Metastasis (18)
- Breast cancer (17)
- Autophagy (16)
- Glioblastoma (16)
- Physical activity (16)
- Publication Year
Articles 1591 - 1620 of 2525
Full-Text Articles in Medicine and Health Sciences
Electrophysiological Investigation Of Rabbit Retinal Ganglion Cells, Przemyslaw Nowak
Electrophysiological Investigation Of Rabbit Retinal Ganglion Cells, Przemyslaw Nowak
All ETDs from UAB
The retina is the first stage of the visual system, responsible for transducing light into the neural signal and for subsequent processing of this signal before sending it to the higher visual centers in the brain. The output to the higher visual centers is mediated by retinal ganglion cells, which not only relay the signal, but also substantially contribute to its processing. Depending on what computations they perform, they are subdivided into different types. These cells have been extensively studied in various spices, one prominent example being the rabbit. In rabbits, one characteristic type comprises On-Off directionally selective retinal ganglion …
Association Between Cc Chemokine Ligand 3-Like-1 (Ccl3l1) Gene Copy Number And Rheumatoid Arthritis In African Americans, Mawuli Kwame Nyaku
Association Between Cc Chemokine Ligand 3-Like-1 (Ccl3l1) Gene Copy Number And Rheumatoid Arthritis In African Americans, Mawuli Kwame Nyaku
All ETDs from UAB
Gene copy number of the CC Chemokine ligand 3-Like-1 (CCL3L1) located on chromosome 17 position q12 varies between ethnicities. Previously, gene copy number of CCL3L1 greater than the ethnic median copy has been associated with an increased risk of Rheumatoid Arthritis. Three later studies found no association between CCL3L1 and RA. All studies were conducted in non-African Americans and an objective of this study was to determine this association in an African American cohort. CCL3L1 shares significant homology with three other genes within the same cluster; CC Chemokine ligand 3 (CCL3), CC Chemokine ligand 3-Like-2 (CCL3L2) and CC Chemokine ligand …
Post-Transcriptional Control Of Type I Interferon Genes By Ksrp In The Innate Immune Response Against Viral Infection, Wei-Jye Lin
Post-Transcriptional Control Of Type I Interferon Genes By Ksrp In The Innate Immune Response Against Viral Infection, Wei-Jye Lin
All ETDs from UAB
Several strategies are used in eukaryotic cells in order to determine the gene expression level, including the transcriptional and post-transcriptional mechanisms. One of the post-transcriptional mechanisms is the regulation of mRNA stability, which varies considerably from one mRNA species to another. Previous studies have shown that inherently unstable mRNAs encoding cytokines and proto-oncogenes contain the AU-rich elements (AREs) in the 3' untranslated regions (UTRs). Their decay requires decay-promoting RNA-binding proteins that recognize the AREs and recruit mRNA decay machineries to facilitate the rapid decay of targeting mRNA. KH-type splicing regulatory protein (KSRP) was previously identified as an ARE decay promoting …
The Effect Of Changes In Tort Laws On Cesarean Section Rates In The United States, Allison Jean Taylor
The Effect Of Changes In Tort Laws On Cesarean Section Rates In The United States, Allison Jean Taylor
All ETDs from UAB
"Defensive medicine", medical practice decisions based on fear of malpractice litigation and where risks may outweigh health and cost benefits, is a proposed contributor to increasing cesarean rates in the U.S. Some studies suggest that changes in laws governing medical malpractice actions may decrease the cesarean rate by relieving pressures driving defensive medicine. This study examined whether, in states that have adopted certain tort reform measures, the probability of having a cesarean delivery is lower following implementation of the reform measures. A database of state legislation and court decisions and National Center for Health Statistics natality data files (1991-2004) were …
Statistical Methods In The Analysis Of Copy Number Variation Data, Nathan Wineinger
Statistical Methods In The Analysis Of Copy Number Variation Data, Nathan Wineinger
All ETDs from UAB
Copy number variation is a significant form of genetic variation that has been shown to influence many traits. However, current methods used to estimate copy number variation are imprecise and prone to errors. This property is demonstrated in a study examining copy number variation in African Americans recruited into the Hypertensive Genetic Epidemiology Network study, and who were genotyped on the Affymetrix 6.0 array. The effect this has on downstream association analyses is explored, an alternative methods are proposed. Finally, a method is proposed that uses linkage disequilibrium between copy number variants and single nucleotide polymorphisms to improve the accuracy …
An Examination Of Statistical Methods For Longitudinal Mediation Modeling, John Paul Bentley
An Examination Of Statistical Methods For Longitudinal Mediation Modeling, John Paul Bentley
All ETDs from UAB
The use of mediation modeling is quite prevalent in a number of disciplines to answer questions about how or why one variable exerts its influence on another variable. Although mediation can be assessed in the context of several types of study designs, the use of cross-sectional data and a single-mediator model tend to be the most commonly reported features in empirical tests of mediation. There are several limitations associated with assessing mediation with cross-sectional data, perhaps the most significant is that mediated effect estimates are biased in the case of true longitudinal mediation. For this and several other reasons, there …
Mechanisms And Consequences Of Thy-1 Shedding, John Edwin Bradley
Mechanisms And Consequences Of Thy-1 Shedding, John Edwin Bradley
All ETDs from UAB
Idiopathic Pulmonary Fibrosis (IPF) is characterized by chronic fibrosis in the lung interstitium of unknown etiology, and causes death within 2 to 4 years after diagnosis. There are no clinical interventions save for lung transplantation that give any survival benefit. Aberrant collagen deposition and aggregates of proliferating fibroblasts and myofibroblasts called fibroblastic foci (FF) are the classic features of IPF. Therefore, the cell type most often implicated as pathogenic in IPF is the fibroblast, especially its differentiated phenotype, the myofibroblast. Fibroblasts are a remarkably heterogeneous cell type. Expression of the cell surface glycoprotein Thy-1 (Thymocyte differentiation antigen 1) delineates a …
The Effect Of An Inclusive Trauma System On Homicide Risk In An Urban Population, Russell Griffin
The Effect Of An Inclusive Trauma System On Homicide Risk In An Urban Population, Russell Griffin
All ETDs from UAB
Homicide is a leading cause of mortality in the United States, with approximately 18,000 homicides occurring annually. Most prevention efforts for homicide are aimed at primary (e.g., culling aggressive behaviors among youth) or secondary (e.g., preventing repeat violence) efforts. To date, there has been limited research on tertiary prevention efforts of homicide (i.e., preventing homicide by preventing deaths from assault-related injuries). With the advent of trauma systems (TS), which allow for rapid emergency medical response for injured individuals, it is possible that these systems may be an ef-fective effort of tertiary prevention of homicides. Using data from the Jefferson County …
The Relationship Between Sunlight And Cerebrovascular Health, Shia T. Kent
The Relationship Between Sunlight And Cerebrovascular Health, Shia T. Kent
All ETDs from UAB
Sunlight radiation may be related to stroke risk through increased vitamin D production. The latter has been associated with a number of conditions including stroke, cognitive function and cardiovascular disease. We performed three sets of analyses to determine whether higher levels of sunlight radiation were associated with lower rates of stroke incidence, all-cause mortality, and cognitive decline. We explored these relationships using the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, a national longitudinal cohort of 30,239 participants. We merged the participants' residential histories with a ground and satellite-derived NASA dataset to characterize 15-year average sunlight radiation and …
Sox2/Parylated Parp1 Complexes Regulate Pluripotency, Yi-Shin Lai
Sox2/Parylated Parp1 Complexes Regulate Pluripotency, Yi-Shin Lai
All ETDs from UAB
Embryonic stem cells (ESCs) were first derived from the inner cell mass (ICM) of blastocyst-stage embryos. ESCs are distinguished from other cell types by their pluripotency and unlimited self-replication. ESCs are able to differentiate into multiple cell types that represent all three primary germ layers (ectoderm, mesoderm and endoderm) and can form an entire adult organism. Under defined conditions, ESCs are self-renewable and have an extended life-span without compromising pluripotency. The plasticity of ESCs provides opportunities for regenerative medicine. The recent production of induced pluripotent stem cells (iPSC) offers an ideal "personalized" substitute for ESCs. Overexpression of four transcription factors, …
A Study Of The Relationships Among Maternal Caregiver Family Management Behaviors, Childhood Asthma Morbidity, And Asthma Control, Linda M. Gibson
A Study Of The Relationships Among Maternal Caregiver Family Management Behaviors, Childhood Asthma Morbidity, And Asthma Control, Linda M. Gibson
All ETDs from UAB
A STUDY OF THE RELATIONSHIPS AMONG MATERNAL CAREGIVER FAMILY MANAGEMENT BEHAVIORS, CHILDHOOD ASTHMA MORBIDITY, AND ASTHMA CONTROL ABSTRACT LINDA GIBSON NURSING Childhood asthma, the most common chronic childhood condition, is associated with high rates of asthma morbidity (emergency department visits, hospitalizations, and school days missed due to asthma). Inadequate asthma control accounts for $1.9 billion annual health expenditures. Numerous studies have identified the relationship of the family caregiver's perception regarding asthma management and the child's asthma outcomes; though few have examined family caregiver asthma management behaviors. Knafl and colleagues (2003) defined family management behaviors as accommodations that family members use …
Understanding Molecular Mechanisms Of Breast Cancer Metastasis Using Genetically-Engineered Mice, Leah M. Cook
Understanding Molecular Mechanisms Of Breast Cancer Metastasis Using Genetically-Engineered Mice, Leah M. Cook
All ETDs from UAB
Morbidity and mortality of breast cancer patients are drastically increased when primary tumor cells metastasize to distant organ sites. Effective treatment of metastatic disease has been limited; therefore, an increased molecular understanding to identify biomarkers and therapeutic targets is needed. Breast cancer metastasis suppressor 1 (BRMS1) suppresses development of metastases when expressed in a variety of cancer types, including metastatic mammary carcinoma. Little is known of Brms1 function throughout the initiation and progression of mammary carcinoma. Thus Brms1 transgenic mice (derived on C57BL/6 background) were generated by utilizing MMTV promoter expression (for mammary-selective overexpression) or the beta-actin promoter (for ubiquitous …
The Effects Of Runx2 Deficiency In Cartilaginous And Mineralized Craniofacial Element, David Summerford
The Effects Of Runx2 Deficiency In Cartilaginous And Mineralized Craniofacial Element, David Summerford
All ETDs from UAB
The development of the orofacial structure in mammals is a highly ordered process that is coordinated activity of epithelial and mesenchymal cells. Chondrocytes and osteoblasts work in close association for development of many cartilaginous skeletal structures and cartilaginous orofacial structures. Two major orofacial structures are the palate and the temporomandibular joint (TMJ). The transcription factor, Runx2, is obligatory for differentiation of mesenchymal cells into chondrocytes and osteoblasts. However, specific contributions of chondrocyte in cartilaginous and mineralized structures of the craniofacial skeleton are not known. Thus, the objective of this study was to discover the regulatory role of Runx2 in chondrocyte …
Individual, Socio-Cultural And Structural Factors Associated With Cervical Cancer Screening And Treatment In Tanzania, Renicha Tomeka Mccree-Hale
Individual, Socio-Cultural And Structural Factors Associated With Cervical Cancer Screening And Treatment In Tanzania, Renicha Tomeka Mccree-Hale
All ETDs from UAB
Most African countries including Tanzania have limited cervical cancer screening and treatment programs. Only about 5% of women have ever been screened for cervical cancer. A constellation of individual and structural factors contributes to the challenge of cervical cancer screening and treatment in countries that bear significant burdens of disease. Yet, little is known about country specific factors that may constrain or facilitate scale up of health services. This dissertation is an attempt to identify and understand the country specific individual and structural barriers along with facilitators to cervical cancer screening and treatment in Tanzania. Individual, institutional and structural level …
Limited Transplantation Of Antigen-Expressing Hematopoietic Stem Cells Induces Long-Lasting Cytotoxic T Cell Responses And Effect Of Altered Suppressive Myeloid Population On Hiv-Disease Progression, Warren L. Denning
All ETDs from UAB
While each type of cancer and chronic viral infection has its own specific pathology, they share two common mechanisms of immune evasion. The first mechanism is the exhaustion or deletion of antigen-specific T cells. The second mechanism is the formation of an immunosuppressive environment responsible for the block of T cell function. Elicitation of antigen-specific T cells be accomplished by immunotherapy in place of conventional treatments such as HAART and chemotherapy. In addition, immunotherapy can alleviate the side-effects associated with long-term use of conventional therapies while reducing the total cost. The results presented here provide an alternative to conventional methods …
Gabaergic Signaling To Adult-Generated Neurons In Hippocampus, Sean Markwardt
Gabaergic Signaling To Adult-Generated Neurons In Hippocampus, Sean Markwardt
All ETDs from UAB
In the central nervous system of adult mammals, new neurons are produced throughout life in at least two regions, the subventricular zone and dentate gyrus of the hippocampus. New neurons in the SVZ migrate via the rostral migratory stream and eventually participate in adaptive olfactory processes. In the dentate gyrus, a variety of physiological functions for continued addition of neurons have been proposed, but its role in normal or pathological conditions remains largely unclear. Neurogenesis in the dentate gyrus consists of the stepwise process of generating fully functional granule cells (GCs) from adult neural stem cells. Regulation of neurogenesis can …
Role Of Calcium-Activated Potassium Channels In Glioblastoma Volume Regulation, Michael Bryan Mcferrin
Role Of Calcium-Activated Potassium Channels In Glioblastoma Volume Regulation, Michael Bryan Mcferrin
All ETDs from UAB
The most common and most malignant gliomas are the Grade IV Glioblastoma Multiforme (GBM), characterized by a highly proliferative tumor mass and extremely invasive phenotype that allows for profuse dispersal of tumor cells throughout the brain. GBM cells must specifically regulate their cell volume to thrive within the edematous tumor mass and infiltrate throughout the tortuous extracellular spaces of the brain. These rapid and directed volume changes are governed by the controlled flux of potassium and chloride ions across the cell membrane, which move osmotically obliged water. The goal of this dissertation was to investigate the role of calcium-activated potassium …
Killer Immunoglobulin-Like Receptors And Human Leukocyte Polymorphisms In Hiv-1 Pathogenesis, Aimee Marie Merino
Killer Immunoglobulin-Like Receptors And Human Leukocyte Polymorphisms In Hiv-1 Pathogenesis, Aimee Marie Merino
All ETDs from UAB
Human leukocyte antigen (HLA) molecules influence the adaptive and innate immune responses through interactions with cytotoxic T lymphocytes and natural killer cells (NK). HLA influence the activation state of NK through direct binding to killer immunoglobulin-like receptors (KIR) and presentation of HLA-derived peptides to NKG2 receptors. Activated NK can kill HIV-infected cells through direct cytolysis and release cytokines that influence other aspects of the immune system. Variations in KIR gene content and allelic variants have been associated with autoimmunity, transplantation success, and infectious diseases such as hepatitis C and HIV/AIDS. We investigated the impact of KIR genes and potential KIR-HLA …
Structural And Mechanistic Studies On Er Upr Sensor Perk And Mitochondrial Translocon Element Tim44, Wenjun Cui
Structural And Mechanistic Studies On Er Upr Sensor Perk And Mitochondrial Translocon Element Tim44, Wenjun Cui
All ETDs from UAB
The unfolded protein response is one mechanism utilized by endoplasmic reticulum (ER) to maintain the homeostasis between ER protein folding machinery and ER proteins. UPR is induced by three ER transmembrane sensors: IRE1, ATF6 and PERK. PKR-like ER kinase (PERK) can sense the ER stress signal through its luminal domain to activate its cytoplasmic kinase domain catalytic activity. PERK kinase domain belongs to the eIF2α family. Members in this family are activated after being autophosphorylated at their activation loops and then specifically phosphorylate eIF2α at its Ser51 position. Phosphorylation of eIF2α can shutdown the cytosol protein translation from the initiation …
Effects Of Estrogen On Hippocampal Function In Young Adult And Aged Female Rats, Lindsey Celeste Vedder
Effects Of Estrogen On Hippocampal Function In Young Adult And Aged Female Rats, Lindsey Celeste Vedder
All ETDs from UAB
In rodents, the ovarian estrogen 17b-estradiol (E2) is a potent modulator of hippocampal function and the hippocampus is critical for many types of learning and memory. Specifically, E2 increase the magnitude of long-term potentiation (LTP) at CA3-CA1 synapses, the density of dendritic spines in CA1 pyramidal cells and current mediated by NR2B-containing NMDA receptors. The E2-induced increase in LTP further requires NR2B-containing NMDARs. While considered a cellular correlate of learning and memory, enhanced LTP does not always predict enhanced learning. The first goal of this dissertation was to investigate the relationship between E2-enhanced LTP and learning and memory in young …
Role Of Nr4a3 Nuclear Receptor In Physiological Regulation Of Metabolism, Grace R. Walton
Role Of Nr4a3 Nuclear Receptor In Physiological Regulation Of Metabolism, Grace R. Walton
All ETDs from UAB
Nuclear receptor NR4A3 (NOR-1, MINOR) mediates transcriptional responses to ß-adrenergic signaling, is increased in insulin sensitive mice and humans, and enhances insulin-stimulated glucose transport in cultured adipocytes and myocytes. We therefore sought to determine the role of NR4A3 in in vivo adipose tissue and skeletal muscle physiology. Following adipose-specific NR4A3 over-expression in mice, we observed reduced circulating epinephrine due to enhanced catabolism of catecholamines in adipose tissue. Furthermore, this reduction in circulating epinephrine produced broad physiological consequences, including poor glucose tolerance, reduced insulin sensitivity, dyslipidemia, poor cardiac function, and behavioral alterations. In skeletal muscle, we show that NR4A3 protein associates …
Strategies For Combined Screening And Imaging Of Breast Cancer, Jason Morgan Warram
Strategies For Combined Screening And Imaging Of Breast Cancer, Jason Morgan Warram
All ETDs from UAB
Successful treatment of breast cancer directly correlates with tumor stage and grade at diagnosis. Early diagnosis leads to a five-year relative survival rate of 96.8% as opposed to only a 22.5% five-year survival rate when diagnosed at late stage. Cancer-specific mechanisms need to be extended to enable cancer detection in an individual patient, in particular, the metastatic burden that currently cannot be assessed by conventional imaging. This approach for cancer detection would remove the biases of patient characteristics, permit immediate diagnostic feedback, improve sensitivity for early detection of small metastatic lesions, and be cost effective. Toward this goal, the cancer-specific …
Ecology And Transmission Of Eastern Equine Encephalitis Virus In The Southeastern United States, Gregory Scott White
Ecology And Transmission Of Eastern Equine Encephalitis Virus In The Southeastern United States, Gregory Scott White
All ETDs from UAB
The virus Eastern Equine Encephalitis virus (EEEV) is a highly pathogenic arthropod-borne virus (arbovirus) present in the US. The virus is listed as a reportable illness to the Centers of Disease Control and Prevention (CDC) and is also listed as a select agent by Human Health and Services (HHS). Studies on EEEV starting back in the 1930's have determined many important facets of the ecology, transmission and evolution of the virus. It is understood that in many endemic foci, the mosquito Culiseta melanura is the primary enzootic vector of the virus. EEEV is thus maintained in an enzootic cycle between …
Conceptualization Of Cervical Cancer And Screening Experiences Among Zambian Women Attending A Cervical Screening Program, Heather Leah White
Conceptualization Of Cervical Cancer And Screening Experiences Among Zambian Women Attending A Cervical Screening Program, Heather Leah White
All ETDs from UAB
Invasive cervical cancer (ICC) is the second most commonly diagnosed malignancy worldwide, and approximately 85% of the disease burden occurs in underdeveloped countries. In 2006, the Zambian government launched a cervical screening program within primary health clinics using visual inspection with acetic acid (VIA) coupled with immediate treatment via cryotherapy. The objective of this dissertation was to determine whether the VIA screening program is responsive to the needs and concerns of Zambian women in an effort to improve screening uptake, and for human immunodeficiency virus (HIV) positive women who are potentially subject to increased ICC screening and treatment, increase long-term …
Functional Interplay Between Trans Factors And Cis-Elements That Govern Il17a&F Transcription, Sarah Kern Whitley
Functional Interplay Between Trans Factors And Cis-Elements That Govern Il17a&F Transcription, Sarah Kern Whitley
All ETDs from UAB
Protective immunity against a variety of infections depends on the amplification and differentiation of naïve antigen-specific CD4 T cells. T helper 17 (Th17) cells are important for defending mucosal barriers from invading extracellular bacterial pathogens. This effector CD4 lineage is characterized by production of the cytokines IL-17A, IL-17F, IL-21, and IL-22, which elicit influx of inflammatory cells to promote pathogen clearance. The cytokines IL-6 and TGF&beta are the principal factors that initiate Th17 lineage development, and the STAT3-inducing cytokines IL-21 and IL-23 assist and/or maintain the Th17 developmental program. Recently, an additional cytokine has been demonstrated to encourage Th17 differentiation: …
Pick It Up, Put It Down: A Grounded Theory Study Of How Low Income African American Patients In The Deep South Start Smoking And Quit Smoking, Jessica Hillman Williams
Pick It Up, Put It Down: A Grounded Theory Study Of How Low Income African American Patients In The Deep South Start Smoking And Quit Smoking, Jessica Hillman Williams
All ETDs from UAB
The purpose of this qualitative was to use data extracted from the narrative stories of African American patients to generate a grounded theory to explain the process and act of initiating and of quitting smoking among low income African American patients in the Deep South. This is important since African Americans are more likely to suffer from smoking-related illnesses, which are the leading cause of death among African Americans. Data were analyzed from interviews conducted in 2005 as part of the Stories Project and supplementary interviews conducted in 2011. Convenience sampling strategies guided participant recruitment for primary interviews and theoretical …
Tear Component Interference In Bead-Based Biomarker Assays Using Magnetic Beads, Larezia Denise Williams
Tear Component Interference In Bead-Based Biomarker Assays Using Magnetic Beads, Larezia Denise Williams
All ETDs from UAB
Cytokines in tears can be biomarkers for ocular inflammation in dry eye subjects. Multiplex bead-based assays measure the concentration of multiple cytokines in a single tear sample. Bio-Rad® polystyrene bead-based assay kits have provided acceptable results for tear samples in this lab. Recently, Bio-Rad decided to replace polystyrene beads with magnetic beads. In earlier experiments in this laboratory, magnetic bead-based as-says did not produce results equivalent to polystyrene bead-based assays. The purpose of this investigation was to modify the magnetic bead-based tear cytokine assay to produce equivalent results to those obtained with the polystyrene bead-based assay. The modifications included running …
Measuring Aniseikonia Using Scattering Filters To Simulate Cataract, Jason Anthony Wilson
Measuring Aniseikonia Using Scattering Filters To Simulate Cataract, Jason Anthony Wilson
All ETDs from UAB
MEASURING ANISEIKONIA USING SCATTERING FILTERS TO SIMULATE CATARACT JASON WILSON DEPARTMENT OF VISION SCIENCE ABSTRACT The relationship between anisometropia and aniseikonia (ANK) is not well understood. Ametropic cataract patients provide a unique opportunity to study this relationship after undergoing emmetropizing lens extraction. Because light scatter may affect ANK measurement in cataract patients, its effect should also be evaluated. The Basic Aniseikonia Test (BAT) was evaluated using afocal size lenses to produce specific changes in retinal height. Several light scattering devices were then evaluated to determine which produced effects most similar to cataract. Contrast sensitivity and visual acuity (VA) losses were …
Enamel Demineralization Around Bonded Orthdontic Appliances Using Resin Coatings, Michael Brett Wood
Enamel Demineralization Around Bonded Orthdontic Appliances Using Resin Coatings, Michael Brett Wood
All ETDs from UAB
Introduction: Orthodontists work to achieve a favorable esthetic and functional result, only to have the outcome tainted by the presence of demineralization upon appliance removal. The presence of WSL's is a disappointment to both orthodontists and patients. Several products have been developed to prevent this unfortunate damage to tooth structure, including "Opalseal" and "Ortho-coat". Opalseal is a 38% filled primer that releases and recharges fluoride. Ortho-coat is a fluoride releasing, light cure, hydrophilic resin that coats both the bracket and tooth surface preventing decalcification. The aim of this study was to investigate the barrier effect of Opalseal and Ortho-coat compared …
Regulation Of Neuronal Death By The Autophagy Lysosomal Pathway: Implications For Parkinson Disease, Violetta N. Pivtoraiko
Regulation Of Neuronal Death By The Autophagy Lysosomal Pathway: Implications For Parkinson Disease, Violetta N. Pivtoraiko
All ETDs from UAB
Parkinson Disease (PD) is the second most common age-related neurodegenerative disorder and is characterized pathologically by the loss of dopaminergic (DA) neurons in the stubstantia nigra pars compacta (SNpc). Mitochondrial dysfunction, increased oxidative stress, and accumulation of aggregated α-synuclein (α-syn), an intracellular protein involved in synaptic function, are all pathological hallmarks of PD have been implicated in PD pathogenesis. However, it is debated whether α-syn aggregates themselves are responsible for neurodegeneration in PD, cellular pathways involved in degradation of α-syn aggregates are believed to promote neuron survival. The autophagy lysosomal pathway (ALP), a physiological mechanism for recycling of intracellular components, …