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Articles 1441 - 1470 of 2525
Full-Text Articles in Medicine and Health Sciences
Microevolution Of Capsule Synthesis Genes Contributes To Pneumococcal Capsule Diversity, Melissa Beth Oliver
Microevolution Of Capsule Synthesis Genes Contributes To Pneumococcal Capsule Diversity, Melissa Beth Oliver
All ETDs from UAB
Streptococcus pneumoniae (pneumococcus) is an important human pathogen that expresses a capsular polysaccharide (PS) to shield underlying antigenic structures from complement-mediated opsonophagocytosis. Thus, capsular PS is the major virulence factor, the target of primary immune responses to pneumococcal infections, and the antigenic component of pneumococcal vaccines. Pneumococci have diverse capsular PS synthesis (cps) loci and express over 90 different capsule types. Such diversity helps pneumococci escape immune detection and adapt to changing environments. Recombination of cps genes has been recognized as the main driver of capsule diversity. However, we show point mutations in cps genes encoding glycosyltransferases can broaden enzymes' …
Msx1 Mutations And Their Binding Interactions, Divakar Prakash
Msx1 Mutations And Their Binding Interactions, Divakar Prakash
All ETDs from UAB
Orofacial clefting (OFC), also called cleft lip and/or palate, is the most common congenital birth anomaly that involve the craniofacial region in humans. The etiology of Non-Syndromic OFC (NS-OFC) is complex and multifactorial; a slew of genetic mutations, standing alone or in combinations, along with several environmental factors, play a major role in the disease process. Numerous linkage and association studies in humans, as well as expression studies and knockout mouse models, have implicated Muscle segment homeobox gene 1 (MSX1), which encodes a homeodomain/DNA binding domain (HD) containing transcription factor as a strong candidate contributing to NS-OFC and Tooth Agenesis …
High Density Genotyping For Immunogenetic Polymorphisms Associated With Transmission And Control Of Hiv-1 Infection In Zambian Heterosexual Serodiscordant Couples, Heather Prentice
High Density Genotyping For Immunogenetic Polymorphisms Associated With Transmission And Control Of Hiv-1 Infection In Zambian Heterosexual Serodiscordant Couples, Heather Prentice
All ETDs from UAB
Understanding host genetic correlates of HIV-1 outcomes in sub-Saharan African populations is of continued importance due to the disproportionate disease burden in this population. We sought to identify genetic variants associated with HIV-1 acquisition in a sample of 439 initially seronegative individuals enrolled in the Zambia-Emory HIV Research Project, as well as novel variants associated with viral load (VL) in a sample of 172 seroconverters (SCs) with an estimated date of infection and 449 seroprevalent individuals (SPs). We were unable to detect any statistically significant associations in our analysis of HIV-1 acquisition, though one signal in the HLA-DOA gene associated …
The Genetic Complexity Of The Human Fc-Gamma Receptor 1q23 Locus And Its Relationship To Autoimmunity, Travis Samuel Ptacek
The Genetic Complexity Of The Human Fc-Gamma Receptor 1q23 Locus And Its Relationship To Autoimmunity, Travis Samuel Ptacek
All ETDs from UAB
The human immune system must be able to adapt to a wide spectrum of invading pathogens in order to keep the human body alive. This variation includes directed recombination and mutation at the level of the individual and genetic variation and natural selection at the population level. A direct consequence of the adaptability of the immune system is autoimmunity: as the immune system adapts to a shifting spectrum of antigens, it can shift to self-antigens, and therefore attack the body and cause disease. Since genetic factors are part of this adaptability, they are also connected with autoimmune disease. SLE is …
The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos
The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos
All ETDs from UAB
Cerebral malaria (CM) is one of the most severe clinical complications of P. falciparum malaria with a fatality rate of 15-30%, and 10% of CM survivors have permanent neurological sequelae. Since inflammation is a central pathophysiological tenet of CM, we began examining the role of the complement system in pathogenesis of experimental cerebral malaria (ECM) using Plasmodium berghei ANKA (PbA) model. Previous studies using this model indicated that mice naturally deficient in complement component C5 were protected from cerebral complications, and wild type mice treated with anti-C5aR antibody were also protected. To determine the protective mechanism of naturally-C5 deficient mice, …
Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf
Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf
All ETDs from UAB
Environmental exposures such as diet, use of antibiotics, and lifestyle have significant impact on the health of an individual. One mechanism that acts as a major pathway in these environmental exposures is the role intestinal commensal microbiota play in both metabolic and immunological responses. Metabolic pathways are altered through changes in metabolites provided by commensal microbiota; alterations in microbial make-up can have drastic impacts on metabolic function. Similarly, the development and maturation of the immune system is dependent on the intestinal microbes to induce tolerance and act as both an immune modulator as well as a barrier against pathogens. We …
A Study Of Multi-Group And Multivariate Tests Of Equivalence With Application To Microarray And, Celeste Yang
A Study Of Multi-Group And Multivariate Tests Of Equivalence With Application To Microarray And, Celeste Yang
All ETDs from UAB
In this dissertation we have adapted two multi-group equivalence tests to be performed on high-dimensional data. The F and Range test for multi-group equivalence were applied to the public microarray dataset GSE11291 to detect equivalently expressed genes. They were also evaluated in terms of type I error and power using single gene simulation and a high-dimension simulation. The F test has higher power than the Range for the same simulated data and parameter settings, in the single gene simulations. The power of the two tests is similar in the high-dimension simulation. The multi-group equivalence tests that were applied to the …
Characterization Of The Mumps Virus Replicase, Robert Marsden Cox
Characterization Of The Mumps Virus Replicase, Robert Marsden Cox
All ETDs from UAB
Negative strand RNA viruses (NSV) are unique because their nucleocapsids are used directly as the template for both transcription and replication. The viral genomic RNA is coated by the nucleoprotein (N) for the entirety of the NSV replication cycle. The viral polymerase, which is composed of the L and P proteins, can only recognize encapsidated RNA as the template for RNA synthesis. Our previous studies have solved the EM structure of the MuV N-RNA complex at 25Å . This structure revealed how the nucleocapsid is assembled and provides an initial model for examining how the viral polymerase may recognize the …
Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar
Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar
All ETDs from UAB
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac sulfide (SS) have shown promising antineoplastic activity in multiple tumor types, but toxicities resulting from cyclooxygenase (COX) inhibition limit their use in cancer prevention. We recently described a N,N-dimethylethyl amine derivative of SS, sulindac sulfide amide (SSA), that does not inhibit COX-1 or -2, yet displays potent tumor cell growth inhibitory activity. Here, we studied the basis for the growth inhibitory effects of SSA on human lung adenocarcinoma cell lines and evaluated its preclinical pharmacology. SSA potently inhibited the growth of lung tumor cells with IC50 values of 2-5 μ compared with 44-52 …
Comparison Of Low Abundance Biomarker Levels In Capillary-Collected Non-Stimulated Tears And Washout Tears Of Aqueous-Deficient And Normal Patients, Nicole Guyette
All ETDs from UAB
Purpose: For patients suffering from aqueous-deficient dry eye, non-stimulated (NS) tear collection can be challenging and time-consuming. Adding a small volume of sterile saline to the eye allows a "washout" (WO) tear collection that takes considerably less time. The primary goal of this project was to determine if WO tear collection is a viable alternative to NS tears for comparing the levels of common ocular surface biomarkers in patients with and without aqueous-deficient dry eye (AD). Stimulated (Stim) tears were also investigated as a second possible alternative to NS tears. Methods: Two studies were conducted, tear cytokine levels being measured …
Predictors Of Colorectal Cancer Surveillance Among Survivors Of Childhood Cancer At High Risk For Subsequent Colorectal Malignancies, Casey Leigh Daniel
Predictors Of Colorectal Cancer Surveillance Among Survivors Of Childhood Cancer At High Risk For Subsequent Colorectal Malignancies, Casey Leigh Daniel
All ETDs from UAB
Childhood cancer survivors who were treated with ionizing radiation are at a significantly higher risk of developing a subsequent colorectal cancer (CRC) compared to the general population. The Children's Oncology Group (COG) recommends that children and adolescents who were treated with radiation therapy of 30 Gy or more to the abdomen, pelvis, or spine undergo a colonoscopy every five years, beginning at age 35 or 10 years after completion of radiation. Despite these recommendations, research indicates low adherence rates to CRC screening among high-risk childhood cancer survivors. Determining the predictors of attending subsequent colorectal cancer surveillance among individuals in this …
Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell
Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell
All ETDs from UAB
Colorectal cancer (CRC) is a heterogeneous disease, and factors such as tumor location, the environment, genetics, and ethnic differences, can influence its development and progression. Over the last few decades, overall CRC mortality rates have declined; however, racial disparities in mortality rates have increased. The discovery of biomarkers that focus on identifying individual differences based on confounders such as tumor stage and patient race/ethnicity is needed, for such biomarkers can lead to development of personalized therapeutic approaches to target these molecules. MicroRNAs (miRNAs) are a class of small molecules that regulate genes at the post-transcriptional level. Altered miRNA expression levels …
Tuberculosis Screening And Treatment Outcomes In Zambia, Jennifer Harris
Tuberculosis Screening And Treatment Outcomes In Zambia, Jennifer Harris
All ETDs from UAB
Zambia is a country in Southern Africa with dual HIV and tuberculosis (TB) epidemics. The annual TB incidence is 444/100,000 and 64% of TB patients are co-infected with HIV. Accurate screening and diagnosis for TB is challenging since it often presents with non-specific signs and symptoms and the available diagnostics are neither sensitive nor specific. Papers one and two of this dissertation focus on the derivation of TB screening rules to more accurately identify high-risk persons in two Zambian populations: inmates and HIV clinic patients. Among inmates, being HIV positive and having a body mass index < 18.5 most strongly predicted HIV disease. Chest pain was also strongly associated, but this may have been a chance finding. For HIV clinic patients, we developed four rules with increasing complexity of clinical tools used for screening. Sensitivity was very high with all rules; the addition of vital signs and pulmonary exam findings to symptom-based screening rules greatly increased the rules' specificity. Furthermore, a rule incorporating pulmonary exam findings performed similarly to a rule with chest radiography suggesting pulmonary exam may be an inexpensive alternative to x-ray. The final paper looks at TB incidence, mortality and intermediate clinical outcomes in a cohort of HIV clinic patients with and without TB during their first 12 months of HIV care. TB incidence was very high during this time period, despite thorough screening at baseline. Mortality was elevated in both culture-confirmed and clinically-diagnosed TB patients, with much of the elevated risk concentrated in TB patients who had culture-confirmed but clinically-unapparent disease. Looking at intermediate outcomes among patients who started anti-retroviral therapy, the change in CD4 cell count was similar for patients with and without TB. TB patients started off with lower mean body weights and hemoglobin concentrations but also showed greater increases over 12 months, thus `catching up' with the TB-negative patients. If these findings are replicable in other cohorts they could have substantial impact on TB screening and diagnostic procedures in resource limited, high burden countries like Zambia.
Therapeutic Potential Of Genetically-Engineered Mesenchymal Stem Cells In Multiple Myeloma, Jerome T. Higgs
Therapeutic Potential Of Genetically-Engineered Mesenchymal Stem Cells In Multiple Myeloma, Jerome T. Higgs
All ETDs from UAB
ABSTRACT Multiple Myeloma (MM) remains the second most common hematologic malig-nancy occurring in adults, which primarily affects the skeletal system causing severe bone destruction, spinal cord compression and hypercalcemia. Current therapies, which include chemotherapy, radiotherapy, autologouos stem cell transplantation and in some cases surgery, have extended the median survival between 3 and 10 years. However, MM is still incurable and therefore improving current therapies or developing newer ones to reduce the burden of osteolytic damage and extend survival rate will be highly beneficial for patient management. The long-term goal of this study is to develop a novel therapeutic approach to …
Regulation Of Glioma Cell Migration And Proliferation By A Non-Selective Cation Channel., Arun Kumar Rooj
Regulation Of Glioma Cell Migration And Proliferation By A Non-Selective Cation Channel., Arun Kumar Rooj
All ETDs from UAB
Two of the most striking features of brain tumors are their unusual ability to robustly proliferate and migrate in the brain. Previous results from our laboratory suggest that glioma cells express a non-selective cation channel that is composed of Epithelial Sodium Channel (ENaC) and Acid Sensing Ion Channel (ASIC) subunits. We hypothesize that this glioma specific current regulates glioma cell migration and proliferation by modulating an intracellular signaling pathway. To test our hypothesis, we have attenuated this cationic conductance by either pharmacological blockers (psalmotoxin-1 and benzamil), or by knocking down expression of a particular subunit of this cross-clade ion channel …
Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah
Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah
All ETDs from UAB
Fc receptors provide an interface between humoral immunity and cellular immunity by binding to the Fc portion of immunoglobulin and mediating effector functions. Cells expressing Fc receptors play a major role in immune complex clearance via phagocytosis, leading to a context dependent pro- or anti-inflammatory environment. Signaling by multi-chain Fc receptor complexes, including FcgRI, FcgRIII, FceRI and FcaRI is mediated by the ITAM-containing common FceRIg (g-chain) subunit. However, despite the use of a common g-chain, different Fc receptor complexes elicit specific cellular programs, suggesting additional layers of regulation of tyrosine based signaling by g-chain. We hypothesized that the unique g-chain …
Automatic Segmentation Of Teeth In Digital Dental Models, David Anton Mouritsen
Automatic Segmentation Of Teeth In Digital Dental Models, David Anton Mouritsen
All ETDs from UAB
Introduction: Within the last decade, there has been an increase in the use of digital records in orthodontics. An orthodontic diagnostic setup is a simulated treatment outcome prepared from dental models. To create a diagnostic setup from digital dental models, the first step is to segment the models, or identify the boundaries of each tooth. In the past, a human operator would manually segment the models using a computer program to draw the boundary that separates the teeth from each other and the gingiva. The ideal, fully automatic, segmentation algorithm would not require a user to interact with the digital …
Neuropathological Alterations In Alzheimer's Disease: An Up Close Look At Sympathetic Sprouting, Amy Renee Nelson
Neuropathological Alterations In Alzheimer's Disease: An Up Close Look At Sympathetic Sprouting, Amy Renee Nelson
All ETDs from UAB
Pathological hallmarks of AD include neurofibrillary tau tangles, amyloid beta (Abeta) accumulation and cholinergic degeneration. Cholinergic degeneration can be mimicked in rats by lesioning cholinergic neurons in medial septum. Hippocampal cholinergic denervation disrupts retrograde transport of nerve growth factor (NGF), leading to its accumulation, which subsequently triggers sprouting of noradrenergic sympathetic fibers from the superior cervical ganglia into hippocampus. Dr. McMahon's lab previously reported that coincident with this sprouting, there is an increase in cholinergic innervation that correlates with a recovery of M1 muscarinic receptor dependent plasticity at CA3-CA1 synapses and visual cortex. These findings suggest that noradrenergic sympathetic sprouting …
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
All ETDs from UAB
Ozone (O3) is a primary component of photochemical smog and represents a serious public health concern as more than 50% of the U.S. population lives in areas exceeding national ambient air quality standards for this toxic pollutant. Recent findings indicate that the effects of inhaled O3 extend to extra-pulmonary tissues like the heart and liver. We hypothesize that inhaled O3 exposure-related events in the lung will cause downstream alterations in the liver proteome. To test this, we exposed male Sprague-Dawley rats to 0.5 ppm ozone for 8 hr a day for 5 days. After exposures, livers were removed and proteomic …
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
All ETDs from UAB
Ozone (O3) is a primary component of photochemical smog and represents a serious public health concern as more than 50% of the U.S. population lives in areas exceeding national ambient air quality standards for this toxic pollutant. Recent findings indicate that the effects of inhaled O3 extend to extra-pulmonary tissues like the heart and liver. We hypothesize that inhaled O3 exposure-related events in the lung will cause downstream alterations in the liver proteome. To test this, we exposed male Sprague-Dawley rats to 0.5 ppm ozone for 8 hr a day for 5 days. After exposures, livers were removed and proteomic …
Environmental And Organizational Characteristics Associated With A Critical Access Hospital Being Contract Managed Or Becoming Acquired, Virginia Anne Razo
Environmental And Organizational Characteristics Associated With A Critical Access Hospital Being Contract Managed Or Becoming Acquired, Virginia Anne Razo
All ETDs from UAB
The focus of this research is the relationship between environmental and organizational characteristics and critical access hospitals (CAHs) being contract managed or acquired. The resource dependence theory guided the methodology. Based on this theory, organizations prefer to remain autonomous until key resources become scarce. The scarcity of resources combined with a dynamic external environment causes environmental uncertainty that requires organizations to consider a variety of strategic responses in order to survive. Given the results of this study, contract managed CAHs were associated with markets that were less munificent and more dynamic with older facilities, relative to independent hospitals. Due to …
Structural Investigations Of Retinoid X Receptor Transcriptional Activation By Anti-Cancer Rexinoids, Leeann J. Boerma
Structural Investigations Of Retinoid X Receptor Transcriptional Activation By Anti-Cancer Rexinoids, Leeann J. Boerma
All ETDs from UAB
Nuclear receptor (NR) protein retinoid X receptor (RXR) is a ligand-inducible transcription factor that binds retinoids for regulation of target genes. Agonist binding induces a major structural rearrangement in the ligand binding domain (LBD) and formation of the coactivator binding interface. RXR-signaling pathways control proliferation, differentiation, and growth in epithelial tissues. To understand how RXR agonists enhance signaling at the molecular level requires an understanding of how agonists induce structural and dynamical changes in the LBD to recruit coactivators for activation of anti-cancer relevant transcription. While most studies of NR activation center on the position of Helix 12 (H12)/activation function-2 …
Myosin Ii Regulates Actin Dynamics Critical For Structural Plasticity And Fear Memory Formation, Cristin Gavin
Myosin Ii Regulates Actin Dynamics Critical For Structural Plasticity And Fear Memory Formation, Cristin Gavin
All ETDs from UAB
Dynamic changes to the actin cytoskeleton are required for synaptic plasticity and long-term memory formation. However, the molecular mechanisms that mediate filamentous actin (F-actin) dynamics during both activity-dependent synaptic potentiation and long-term memory encoding are poorly understood. Myosin II motor proteins are highly expressed in actin-rich growth structures in neurons, including dendritic spines. Recent work demonstrates that these molecular machines mobilize F-actin in response to synaptic stimulation and are required for memory encoding in CA1 hippocampus of rodents. The aims of this project were two-fold. First, we sought to establish if myosin II regulates actin filament polymerization necessary for structural …
Childhood Obesity: The Role Of Genetic Admixture, Parental Feeding Practices, And The School Food Environment, Michelle Cardel
Childhood Obesity: The Role Of Genetic Admixture, Parental Feeding Practices, And The School Food Environment, Michelle Cardel
All ETDs from UAB
Disentangling the etiology of pediatric obesity continues to challenge researchers due to the interconnecting of behavioral, physiological, environmental, and genetic factors. Studies have focused on the role of the obesogenic environment, characterized by excess energy intake and sedentary behavior, as it relates to weight and fat gain in children. Although these factors certainly have an impact on fat accumulation, increased energy intake and decreased physical activity do not solely account for the increasing trends in obesity prevalence. Less explored genetic and environmental factors may contribute independently and/or synergistically to the current obesity epidemic, and that, these factors could vary in …
Characterization Of Pleiotrophin And Receptor Protein Tyrosine Phosphatase Beta/Zeta In Odontoblast And Osteoblast Cell Lines, Amena Tamkenath
Characterization Of Pleiotrophin And Receptor Protein Tyrosine Phosphatase Beta/Zeta In Odontoblast And Osteoblast Cell Lines, Amena Tamkenath
All ETDs from UAB
Pleiotrophin (PTN) is an extracellular matrix-associated growth factor and chemokine expressed in mesodermal and ectodermal cells. It plays an important role in osteoblast recruitment and differentiation. PTN has two well-known physiological receptors, protein tyrosine phosphatase beta/zeta (RPTPRZ1), and N-syndecan. Protein tyrosine phosphatases are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine phosphorylation is a common post-translation modification that can create novel recognition motifs for protein interactions and cellular localization, affect protein stability and regulate enzyme activity. Osteoblasts have recently been found to express the short transmembrane isoform of RPTP beta/zeta but nothing …
Real-Time Quantitative Pcr For Evaluation Of Mutans Streptococci And Dental Caries, Chanika Manmontri
Real-Time Quantitative Pcr For Evaluation Of Mutans Streptococci And Dental Caries, Chanika Manmontri
All ETDs from UAB
Mutans streptococci (MS), e.g., Streptococcus mutans (Sm) and Streptococcus sobrinus (Ss), are associated with dental caries. Quantification of MS has been shown to predict caries risk. A new technology using PCR may streamline quantification compared to traditional culture methods. Purpose: To use real-time quantitative PCR (qPCR) and standard plate counting (SPC) for detection and quantification of levels of Sm, Ss and total streptococci (TS) in clinical samples from high-caries-risk children with no regular access to dental care and to study correlation of these bacterial levels and ratios to caries prevalence. Methods: Saliva and plaque samples were collected from school-aged children …
Localization Of Proteins Involved In Trafficking In Frog And Mouse Retina, Amie Marsh
Localization Of Proteins Involved In Trafficking In Frog And Mouse Retina, Amie Marsh
All ETDs from UAB
The connecting cilium serves as the major route for protein transport from the inner to outer segment of photoreceptor cells. The hypothesis that all Congenital Stationary Night Blindness (CSNB) rhodopsin mutants travel properly to the rod outer segment in Xenopus laevis will be tested by preparing transgenic X. laevis expressing a rhodopsin mutation found in human CSNB, A295V. In addition, probing for the existence of potential proteins involved in regulating rhodopsin trafficking and monitoring their localization will contribute to a better understanding of the underlying pathway of intracellular photoreceptor trafficking.
An Investigation Of The Effect Of Misspecifying The Random Effect Distribution And The Incorrect Assumption Of Equal Intraclass Correlation Coefficients Among Treatment Groups In The Analyses Of Data From Cluster Randomized Trials, Omar B. Mbowe
All ETDs from UAB
Generalized linear mixed models (GLMM) are among the commonly used statistical methods for the analyses of binary data from cluster randomized trials (CRT). GLMMs extend the linear mixed models to accommodate, among others, binary outcomes. The linear predictor of GLMMs contains fixed effects and random effects to model the correlation among responses in a cluster. These random effects are usually assumed to be normally distributed but this assumption may not hold in practice. Also, the cluster sizes may vary within a trial for several reasons including loss to follow-up. This variation in cluster sizes can result in unequal cluster sizes. …
Relationship Between Religiosity, Violent Behavior And Gang Activity In Economically Disadvantaged Adolescents, David Mckenzie
Relationship Between Religiosity, Violent Behavior And Gang Activity In Economically Disadvantaged Adolescents, David Mckenzie
All ETDs from UAB
RELATIONSHIP BETWEEN RELIGIOSITY, VIOLENT BEHAVIOR AND GANG ACTIVITY AMONG ECONOMICALLY DISADVANTAGED ADOLESCENTS DAVID McKENZIE HEALTH EDUCATION & HEALTH PROMOTION ABSTRACT Few studies have examined the relationship between religiosity, violent behavior and gang activity in disadvantaged youth. This research study analyzed data from a population of low-income adolescents in Mobile, Alabama. The research objectives were to assess the relationship between adolescent religiosity and involvement in violent behavior and gang activity, and to determine if there were gender differences between boys and girls regarding religiosity, violent behavior and gang activity. It was hypothesized that there would be an inverse relationship between religiosity …
The Effect Of A Topical Ocular Preparation On Performance Of Simulated Driving In Cases Of Symptomatic Dry Eye, Chandra Venise Mickles
The Effect Of A Topical Ocular Preparation On Performance Of Simulated Driving In Cases Of Symptomatic Dry Eye, Chandra Venise Mickles
All ETDs from UAB
Dry eye is a common complaint of millions of people worldwide with a significant impact on quality of life. In particular, it could have a significant impact on vision-related activities of daily living such as driving. The purpose of this investigation was to determine if 30 days of active topical dry eye treatment (Systane® Balance, Alcon Laboratories; Ft. Worth, TX) has an impact on the simulated night-time driving performance in mild or moderate dry eye compared to a topical saline (Sensitive Eyes®, Bausch & Lomb; Rochester NY). Dry eye symptoms and signs were also assessed to corroborate our findings. Forty …