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Articles 1351 - 1380 of 2525

Full-Text Articles in Medicine and Health Sciences

Structure-Function Analysis Of Tyrosyl-Dna Phosphodiesterase I, Evan Comeaux Jan 2013

Structure-Function Analysis Of Tyrosyl-Dna Phosphodiesterase I, Evan Comeaux

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Tyrosyl-DNA phosphodiesterase I (Tdp1) functions to remove 3'phospho-DNA adducts, such as eukaryotic DNA Topoisomerase I (Top1) covalently bound to the DNA by a 3'phospho-tyrosyl bond. As member of the Phospholipase D superfamily Tdp1 contains two HxK(n)N motifs, each of which provide a catalytic histidine: one functioning as a nucleophile to bind the 3'phosphate and the other as a general acid/base to hydrolyze Tdp1's 3'phospho-histidyl bond. Mutation of the general acid/base catalytic histidine (Hisgab) to arginine has been implicated in the autosomal recessive neurodegenerative disease SCAN1. Further study of the yeast enzyme revealed that substitution of Hisgab in yeast Tdp1 to …

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Comparison Of Fabricated Carbon Nanotube Sorbent Felts And 3m Charcoal Sorbent Wafers To Assess Passive Sampling, Samantha Connell Jan 2013

Comparison Of Fabricated Carbon Nanotube Sorbent Felts And 3m Charcoal Sorbent Wafers To Assess Passive Sampling, Samantha Connell

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Passive air sampling is the preferred method of air sampling for many applications. Traditionally, this method uses activated charcoal as the sorbent and samples are analyzed by chemical or thermal desorption. This research explores the use of carbon nanotubes in the form of a felt as a sorbent for passive sampling by comparing the mass uptake and percent yield to that of the 3MTM Organic Vapor Monitor (OVM) 3500 over four time trials. The desorption efficiency, adsorption capacity, and mass uptake of the fabricated felts are very similar to the 3MTM OVM 3500. It was expected that the fabricated felts …

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Understanding The Function And Regulation Of Eukaryotic Release Factor 1, Erf1, Sara Elisabeth Conard Jan 2013

Understanding The Function And Regulation Of Eukaryotic Release Factor 1, Erf1, Sara Elisabeth Conard

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Translation termination is an essential eukaryotic process that facilitates the end of protein synthesis and mediates the release of the nascent peptide chain. Two release factors, eRF1 and eRF3, with the help of a ribosome recycling factor assist in this process. eRF1 and eRF3 form a stable complex through conserved regions in their C-terminal domains. The eRF1/eRF3 complex, along with GTP, is absolutely vital for efficient termination in vitro and in vivo. The role of eRF1 during translation termination is to recognize the stop codon located in the ribosome aminoacyl site, stimulate GTP hydrolysis of eRF3 and enable peptide release …

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Tgf-Ss And Erg In Intervertebral Disc Development, Megan Karen Cox Jan 2013

Tgf-Ss And Erg In Intervertebral Disc Development, Megan Karen Cox

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The intervertebral disc (IVD) is a fibrocartilaginous tissue that acts as a shock absorber between adjacent vertebrae in the spinal column. It is comprised of two parts, the inner jelly-like nucleus pulposus (NP) and the outer more fibrous annulus fibrosus (AF). Most IVD research has focused on the development of the NP, which is derived from condensations of the notochord involving sonic hedgehog (Shh) signaling. In contrast, very little is known about the molecular mechanisms underlying the specific development of the AF of the IVD. The AF is derived from the sclerotome, which is formed by the ventral half of …

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Selection And Evolution Of Pneumococci In Response To Conjugate Vaccines, Christina M. Croney Jan 2013

Selection And Evolution Of Pneumococci In Response To Conjugate Vaccines, Christina M. Croney

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Pneumococcal conjugate vaccines (PCVs) containing subsets of the >90 capsular polysaccharide antigens have been successful as a means of decreasing invasive and non-invasive pneumococcal disease worldwide. However, this success is limited to the specif-ic capsular serotypes against which PCVs are formulated and studies have reported the increase of nonvaccine serotypes. The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the United States in 2010 for the prevention of invasive pneumococcal disease (IPD) and otitis media and was released without efficacy data. In this study we set out to 1) determine potential efficacy for invasive and noninvasive pneumococcal disease and 2) …

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An Investigation Of Trem-Like Transcript 2 Expression, Kimberly Anne Thomas Jan 2013

An Investigation Of Trem-Like Transcript 2 Expression, Kimberly Anne Thomas

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Acute inflammation is a necessary component for the clearance of pathogens. Cells at the site of infection utilize highly conserved receptors to both recognize microbes and induce the production of pro-inflammatory stimuli. These stimuli set off a chain reaction that includes localized vasodilation, leukocyte infiltration, and tissue destruction, collectively known as inflammation. Tightly controlled, this process is protective, and can compartmentalize the damage to a defined area, but when dysregulated can be catastrophic, inducing chronic inflammation and even death. Families of innate receptors can modulate inflammatory processes, and in doing so, increase or decrease their severity, as well as tailor …

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Influence Of Implant Angulation On The Fracture Resistance Of Zirconia Abutments, Shreedevi Thulasidas Jan 2013

Influence Of Implant Angulation On The Fracture Resistance Of Zirconia Abutments, Shreedevi Thulasidas

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Zirconia-based implant abutments are widely used in prosthetic dentistry. Custom made abutments are utilized to correct for non-ideal implant positions and can successfully accommodate the morphologic requirements of the overlying crown. It was hypothesized that there will be difference in fracture strength and fracture mode of artificially aged zirconia implant abutments supported by implants at varying angulation, when load is applied to failure on overlying zirconia crowns. The implant-abutment-crown assemblies were subjected to steam autoclaving to induce some degree of phase transformation from tetragonal to weaker monoclinic form and to thermo-cycling to artificially age the samples. The effects of loading …

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Neutropenia And Progenitor Cell Mobilization In Ap3-B1 Mutant Pearl Mice, Matthew Vallejo Jan 2013

Neutropenia And Progenitor Cell Mobilization In Ap3-B1 Mutant Pearl Mice, Matthew Vallejo

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Mutations in the AP3-ß1 gene are known to cause Hermansky-Pudlak syndrome type 2 (HPS2) in humans and canine cyclic hematopoiesis (CH) in gray collie dogs. HPS2 patients have severe congenital neutropenia (SCN), and dogs have cyclic neutropenia (CN). The mechanism behind neutropenia is uncertain. Pearl mice have an AP3-ß1 mutation, but whether they actually have neutropenia has not yet been evaluated. This dissertation presents a discussion of the evaluation of neutropenia in pearl mice, hematopoietic progenitor cell mobilization defect in pearl mice and finally an evaluation of methods of dog-to-mouse xenotransplantation to establish a xenotransplant model of the dog hematopoietic …

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Intrinsic Properties Of Rna Polymerase I And Trans-Acting Factors Control Transcription Elongation Efficiency, Olga V. Viktorovskaya Jan 2013

Intrinsic Properties Of Rna Polymerase I And Trans-Acting Factors Control Transcription Elongation Efficiency, Olga V. Viktorovskaya

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Transcription of ribosomal (r) DNA by RNA polymerase I (Pol I) is the initial step of ribosome synthesis. Pol I transcription is unique in its high rate of initiation, specific organization within the nucleolus and tight connection to cell growth and proliferation. Moreover, transcription elongation by Pol I is functionally coupled with rRNA processing and assembly of the ribosomes. Regulatory insights into transcription elongation by Pol I and its interface with rRNA processing are limited, despite decades of research. To fulfill that gap, we asked several important questions: Do the obvious functional divergences between Pol I and other eukaryotic polymerases …

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Association Between Cruciferous Vegetable Intake And Risk Of Colorectal Cancer Among Men In Shanghai, China, Emily Vogtmann Jan 2013

Association Between Cruciferous Vegetable Intake And Risk Of Colorectal Cancer Among Men In Shanghai, China, Emily Vogtmann

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Colorectal cancer (CRC) is a major global health concern and the intake of certain foods, such as cruciferous vegetables, has been studied for their potential protective effects against cancer development. The observed association between cruciferous vegetable consumption and CRC has been inconsistent, possibly related to glutathione S-transferase (GST) gene polymorphisms. Therefore, we aimed to (1) evaluate the association between fruits and vegetables, including cruciferous vegetables, on the risk of CRC; (2) determine factors associated with urinary isothiocyanate (ITC), a biomarker of cruciferous vegetable intake; and (3) evaluate the association between cruciferous vegetable consumption and CRC and to estimate the potential …

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Glioma-Vasculature Interactions, Stacey Watkins Jan 2013

Glioma-Vasculature Interactions, Stacey Watkins

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Malignant gliomas are highly invasive brain tumors, which lack effective treatment options. To date, the standard therapy includes surgical debulking followed by chemotherapy and radiation. Despite efforts to eradicate the disease, the median patient survival time is only 14 months. In an attempt to discover novel therapies, research has focused on understanding the heterogeneous biological mechanisms employed by these cells. Uniquely, they do not metastasize through the vasculature or lymphatics like other solid cancers but alternatively, glioma cells utilize the abluminal surface of the vasculature to guide invasion and migration throughout the brain. The intimate association between glioma cells and …

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Effect Of A Faith-Based Initiative On Hospital Readmissions, Joseph Webb Jan 2013

Effect Of A Faith-Based Initiative On Hospital Readmissions, Joseph Webb

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EFFECT OF A FAITH-BASED INITIATIVE ON HOSPITAL READMISSIONS JOSEPH WEBB ADMINISTRATION-HEALTH SERVICES ABSTRACT The purpose of this study was to examine the relationship between a faith-based initiative and hospital readmissions. The main data source used was the inpatient data-base of Methodist LeBonheur Healthcare System (MLH) in Memphis, TN. Data were collected from admissions that occurred during years 2008 through 2012 at four of MLH's five adult acute-care hospitals. Data from the U.S. Census Bureau's American Community Survey were also used in the study. This study uses theoretical tenets from the Social Justice and Equity Theory and the Chronic Care Model …

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Hur Regulation In Central Nervous System Disorders, Crystal G. Wheeler Jan 2013

Hur Regulation In Central Nervous System Disorders, Crystal G. Wheeler

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In inflammatory diseases of the central nervous system (CNS), astrocytes play a major role in the systemic response to disease by either enhancing or limiting the inflammatory response through secretion of growth factors or cytokines. HuR RNA binding protein regulates many genes involved in inflammation. Inflammatory diseases such as brain tumors, Amylotrophic Lateral Sclerosis (ALS), and Multiple Sclerosis (MS), have been linked to HuR, by our laboratory and others. To determine whether astrocytic overexpression of HuR would regulate inflammation in diseases of the CNS, we designed a transgenic mouse in which the HuR gene is overexpressed. In the first study, …

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Insulin Resistance, Lipids, And The Metabolic Syndrome Trait Cluster: Impact Of Race And Very Low Calorie Diet, Veeradej Pisprasert Jan 2013

Insulin Resistance, Lipids, And The Metabolic Syndrome Trait Cluster: Impact Of Race And Very Low Calorie Diet, Veeradej Pisprasert

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Insulin resistance (IR) is central to the pathogenesis of cardiometabolic disorders. Early detection, along with appropriate interventions, is paramount to reduce the morbidity and mortality of IR-related diseases. The gold standard measurement for IR is the hyperinsulinemic-euglycemic clamp, which is markedly sophisticated for clinical evaluation but costly and invasive for clinical practice. Several alternative surrogate indicators of IR have been identified and used by clinicians, including insulin sensitivity indices derived from plasma glucose and insulin values, as well as other indicators that are independent of direct insulin measurements. In addition, lipid panel and lipoprotein subclass profile have emerged as markers …

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Socioeconomic Predictors Of 30-Day Readmission Of Elderly Patients With Initial Discharge Destination Of Home Health Care, Dianne Marrie Richmond Jan 2013

Socioeconomic Predictors Of 30-Day Readmission Of Elderly Patients With Initial Discharge Destination Of Home Health Care, Dianne Marrie Richmond

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Introduction The purpose of this study was to examine the association of social determinants of health with 30-day rehospitalization among elderly patients who were discharged from an acute care hospital with an initial discharge destination of home with home health care support and to explore the social determinants' ability to accurately predict the odds of rehospitalization. Methods A secondary data analysis was performed on data obtained from the home healthcare agency. A total of 4,717 unique patients found in the data set. Some patients were represented in the data more than once during the observation period. To examine the relationship …

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Studies Of Dna Gyrase Activity In Escherichia Coli And Salmonella Enterica Serovar Typhimurium., Nikolay Sergeyevich Rovinskiy Jan 2013

Studies Of Dna Gyrase Activity In Escherichia Coli And Salmonella Enterica Serovar Typhimurium., Nikolay Sergeyevich Rovinskiy

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Gyrase introduces negative supercoils into bacterial DNA. In balance with topoisomerase I, it contributes to the maintenance of constant negative DNA supercoiling. It was shown that in Escherichia coli negative supercoil density of pBR322 plasmid is higher than in Salmonella typhimurium. One of the possible explanations of this phenomenon is a difference of DNA gyrase activity between E. coli and S. typhimurium. We developed in vitro assay of gyrase activity which has shown that DNA gyrases of E. coli and S. typhimurium have the same supercoiling end point, but E. coli gyrase works slightly faster than the S. typhimurium enzyme. …

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Role Of Gsk3 In The Immunopathogenesis Of Eae, Amber Rowse Jan 2013

Role Of Gsk3 In The Immunopathogenesis Of Eae, Amber Rowse

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Lithium, a glycogen synthase kinase 3 (GSK3) inhibitor, ameliorates experimental autoimmune encephalomyelitis (EAE), the murine model of multiple sclerosis (MS) in different mouse models. However, the mechanism of lithium's attenuation of EAE and the role of GSK3 in these processes are currently unknown. IFN-g producing Th1 cells and IL-17-producing Th17 cells are both effector cells in MS and in EAE models. However, relapsing remitting MS patients segregate into Th1 or Th17 serum cytokine signatures and each is differentially responsive to IFN-ß therapy, a first line therapy for MS. Studies in this dissertation revealed a differential effect of lithium on Th1 …

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Role Of Endothelial Mannose Residues In Monocyte Adhesion Under Flow, David Wayne Scott Jan 2013

Role Of Endothelial Mannose Residues In Monocyte Adhesion Under Flow, David Wayne Scott

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Atherosclerosis is a chronic inflammatory disease of the vessel wall and underlying cause of most cardiovascular disease. Much is understood about the nature of atherosclerosis development, including contributions from leukocytes that drive the disease process forward. The general process by which leukocytes are trafficked to sites of atherosclerosis development, and sites of inflammation in general, is understood and relies upon endothelial expressed protein adhesion molecules which serve as ligands for cognate leukocyte receptors. While these adhesion molecules share the post-translation modification of N-glycosylation, relatively little is known as to what functional role these modification plays in: i) interactions of leukocytes …

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Spatial Analysis Of Cardiovascular Mri Data, Samantha Seals Jan 2013

Spatial Analysis Of Cardiovascular Mri Data, Samantha Seals

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The goal of this dissertation is to investigate applying currently available Frequentist spatial analysis methods to cardiovascular MRI (cMRI) data. This data is typically analyzed using methods dependent summary statistics; our goal is to analyze using the full dataset. In our first paper, we explore application of spatial covariance structures to cMRI data via a generalized linear model. In our second paper, we examine the effects of misspecification of the covariance structure when analyzing spatially correlated data utilizing generalized linear models via Monte Carlo simulation. Finally, in our third paper, we propose an alternative family of covariance structures that lends …

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Epigenetic Markers In The Developing Postnatal Brain, Rebecca Kaye Simmons Jan 2013

Epigenetic Markers In The Developing Postnatal Brain, Rebecca Kaye Simmons

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Epigenetic mechanisms provide a critical and plausible mechanism by which genes and the environment can interact and have been implicated in a number of diseases and disorders. In order to better understand how epigenetic mechanisms go awry in a diseased brain we must first understand how epigenetic mechanisms unfold during normal development. The present body of work begins to examine the role of DNA methylation in normal development and how it may contribute to a rodent model of emotion dysfunction. Using a variety of techniques, we evaluated the transcript, protein and functional output levels of DNA methyltransferase1, -3a, and -3b …

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Microrna Regulation Of Dlx3 During Odontoblast Differentiation, Hannah Maria Heair Jan 2013

Microrna Regulation Of Dlx3 During Odontoblast Differentiation, Hannah Maria Heair

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MicroRNAs are endogenous non-coding RNA (~22nt) that bind to the 3' untranslated region (UTR) of target messenger RNA (mRNA) and facilitate translational repression and degradation. Previous studies have demonstrated the essential role of miRNA in many biological processes, including skeletal development and tooth formation. Dlx3, a homeobox gene, is critical for craniofacial patterning and postnatal skeletal development. Mutations in the Dlx3 gene in humans result in two autosomal dominant phenotypes known as tricho-dento-osseous syndrome (TDO) and amelogenesis imperfecta with taurodontism (AIHHT). Dlx3 expression has been observed in cranial neural crest cells, endochondral osteoblasts, odontoblasts, ameloblasts, hypertrophic chondrocytes, and the developing …

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The Role Of Autosomal Dominant Retinitis Pigmentosa Rhodopsin Mutant Ter349glu In Rod Cell Biogenesis And Retinal Inflammation, Tj Hollingsworth Jan 2013

The Role Of Autosomal Dominant Retinitis Pigmentosa Rhodopsin Mutant Ter349glu In Rod Cell Biogenesis And Retinal Inflammation, Tj Hollingsworth

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Retinitis pigmentosa is one of the most common inherited blinding disorders, affecting 1 in 4000 individuals world-wide. Approximately 30% of retinitis pigmentosa cases are dominantly inherited and approximately 30% of these dominant mutations are found in rhodopsin. Most rhodopsin mutations result in misfolded protein aggregates and subsequent apoptosis while others have been shown to result in apoptosis associated with mislocalization, diminished/enhanced activity, or faulty protein-protein interactions. This work serves to test for mechanisms by which the naturally-occurring Ter349Glu rhodopsin mutation causes rod cell death. Ter349Glu rhodopsin was tested for the ability to bind the ligand 11-cis retinal, photoactivate, and activate …

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Identification And Biochemical Investigations Of Rhamnose And Glycoprotein In Mycoplasmas, David Jordan Jan 2013

Identification And Biochemical Investigations Of Rhamnose And Glycoprotein In Mycoplasmas, David Jordan

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Mycoplasmas are host-specific human and animal pathogens within the class of wall-deficient bacteria named Mollicutes and have smaller sizes and genomes than the walled bacteria. Mycoplasma genome sequences reveal few if any genes for synthesis of a glycocalyx. Nevertheless, we find that mycoplasmas produce glycolipids, glycoprotein, and polysaccharides. Using gas chromatography and mass spectrometry, glucose, mannose, rhamnose, and galactose were detected in the glycolytic species Mycoplasma pneumoniae and Mycoplasma pulmonis. All of these sugars except galactose was found in Mycoplasma arthritidis. Rhamnose was in the rare D configuration in the glycolytic species and in both D and L forms in …

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Modulation Of Intrinsic Activity In Sensory Cortex Facilitates Task Performance, Aburahman Elkhetali Jan 2013

Modulation Of Intrinsic Activity In Sensory Cortex Facilitates Task Performance, Aburahman Elkhetali

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Due to the changing demands of the environment and our behavioral intentions the brain has to adapt in order to produce task appropriate responses. Part of the challenge is the large amount of sensory information received by the brain. Depending on individu-al goals, the brain must select and react to task appropriate stimuli while ignoring other irrelevant sensory input. Since behavioral intentions are dynamic, this requires the re-sponses within the brain to also be dynamic. Cognitive control, exerted by higher centers on sensory cortex allow for selection of task relevant stimuli. In this study we find that intrinsic, non-stimulus driven …

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Studies On Distracted Driving: Three Papers Examining The State Of The Literature And The Impact Of Texting Restrictions On Motor Vehicle Crash-Related Fatalities And Hospitalizations, Alva Oletia Ferdinand Jan 2013

Studies On Distracted Driving: Three Papers Examining The State Of The Literature And The Impact Of Texting Restrictions On Motor Vehicle Crash-Related Fatalities And Hospitalizations, Alva Oletia Ferdinand

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ABSTRACT This three-paper dissertation addresses gaps in the literature focused on distracted driving and the impact of regulations aimed at reducing its prevalence. With the widespread proliferation of mobile phone usage and more sophisticated in-vehicle entertainment and information systems, it is now commonplace for drivers to engage in non-driving activities (also referred to as "secondary tasks") while driving. It is widely believed that distracted driving is positively related to motor vehicle crashes and other undesirable driving outcomes. This dissertation specifically focuses on three topics: (1) the nature of the distracted driving literature given the numerous secondary tasks, driving performance outcomes, …

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Polymerization Shrinkage Strain Versus C-Factor And Placement Method For Dental Composites, Shashank Godbole Jan 2013

Polymerization Shrinkage Strain Versus C-Factor And Placement Method For Dental Composites, Shashank Godbole

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Polymerization shrinkage is an important property when restoring teeth with dental composites since resins shrink during polymerization creating stress and strain around the restoration. This may produce failure at the composite-tooth interface. This leads to marginal gaps, staining, post-operative sensitivity, secondary caries, and crack development within the body of a tooth. It is critical to be able to measure polymerization strain produced during composite polymerization. Objective: To measure and compare the polymerization shrinkage strain of various bulk and incrementally placed composites using a novel and recently developed model with different C-factors. Methods: Teflon molds were used to prepare Z100 composite …

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Regulation Of Capsule By Cpsa And Global Regulatory Networks In Streptococcus Pneumoniae Type 2, Kanupriya Gupta Jan 2013

Regulation Of Capsule By Cpsa And Global Regulatory Networks In Streptococcus Pneumoniae Type 2, Kanupriya Gupta

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Streptococcus pneumoniae is a major human pathogen that can reside asymptomatically in the nasopharynx before causing invasive disease by entering systemic sites. This involves regulation of colonization and virulence factors including capsule. cps2A, the first gene of the capsule (cps) locus has been proposed to regulate capsule, however its exact role and mechanism is not well understood. A complete deletion of cps2A resulted in enhanced capsule levels, with no alteration in the transcription levels of cps genes. Complementation of Cps2A restored wild type levels of capsule. Expression of the C-terminal tail alone was able to partially complement the deletion strain, …

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Relationships Between Latino Parental, Adolescent And Cultural Variables On Adolescents' Attitudes, Norms, Self-Efficacy, And Sexual Intentions, Vanessa Pirani Gaioso Jan 2013

Relationships Between Latino Parental, Adolescent And Cultural Variables On Adolescents' Attitudes, Norms, Self-Efficacy, And Sexual Intentions, Vanessa Pirani Gaioso

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The quantity and quality of parent-adolescent sexual communication has been suggested as the best predictor on adolescent sexual behavior. The purpose of this study was to test a theoretical model based on the Parent-Based Expansion of the Theory of Planned Behavior (PETPB) examining relationships between selected parental, adolescent and cultural variables and Latino adolescents' intentions to engage in sexual behavior. This study used a cross-sectional correlational design based on a secondary data analysis of 130 Latino parent and adolescent dyads. Regression and path analysis procedures were used to test seven research hypotheses and the results demonstrated partial support for the …

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Potential Roles Of The Immunostimulatory Signals Il-15 And Mica In Oncolytic Hsv-1 Therapy For Malignant Glioma, David Curtis Gaston Jan 2013

Potential Roles Of The Immunostimulatory Signals Il-15 And Mica In Oncolytic Hsv-1 Therapy For Malignant Glioma, David Curtis Gaston

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Malignant gliomas are the most frequently diagnosed and the most fatal primary brain tumors. Innovative therapeutic approaches are necessary to combat these devastating cancers, and oncolytic herpes simplex virus type-1 (oHSV) deleted of the γ134.5 neurovirulence gene is a promising adjunctive therapy. The primary mechanism of tumor clearance by oHSV is lytic replication specifically within malignant cells. oHSV also stimulates tumor infiltration of cytotoxic immune effector cells that can participate in tumor clearance. However, cytotoxic immune cells target oHSV as well as tumor, which may limit therapeutic efficacy. Further knowledge regarding the nature of these interactions and how the interactions …

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The Impact Of Weight Status On The Adoption Of Self-Care Behaviors Among Heart Failure Patients, Bern'nadette Knight Jan 2013

The Impact Of Weight Status On The Adoption Of Self-Care Behaviors Among Heart Failure Patients, Bern'nadette Knight

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Self-care is a major component of heart failure management. Excess weight is a disease that may negatively affect a patient's ability to effectively practice self-care. The project aimed to assess 1) the relationship between weight status and heart failure self-care behaviors and 2) the modification of the relationship between social support and heart failure self-care by weight status. This cross sectional study utilized baseline data from a cohort of African-American and Caucasian participants diagnosed with heart failure. The heart failure cohort was formed from three larger studies (n=690) designed to assess the relationships among social support, self-care behaviors and hospital …

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