Medicine and Health Sciences Commons^™

Examining The Relationship Between Medical Student Satisfaction And Academic Performance In A Pre-Clinical, Flipped-Classroom Curriculum, Matthew J. Mackey

Scholarship in Medicine - All Papers

Medical schools are tasked with the responsibility of facilitating the acquisition of the specific vernacular, skill set, and reasoning capabilities of a physician for a group of individuals with a mélange of diverse experiences. Determining the best methods to train physicians is thus a challenge for those in medical education. Starting with the class of 2021, flipped classroom teaching and learning activities dominate Wright State University Boonshoft School of Medicine’s (WSU-BSOM) curriculum for MS1s and MS2s. This new curriculum is under constant evaluation to make sure it is best serving Boonshoft students. However, evaluating student evaluations on course satisfaction is …

Medical Students' Understanding Of The Nature Of Science, Garrett V. Kandell

Scholarship in Medicine - All Papers

A questionnaire pertaining to the nature of science was distributed to 120 students matriculating into a midwestern medical school. Questions were so designed to understand student’s ideas on the nature of science and research, their previous involvement in research, and how they see research playing a role in their lives as future physicians. This study was performed to gain a more accurate understanding of what medical students perceive the nature of science and research is along with possible benefits throughout their careers There is a division in literature concerning the benefits of research in medical school and its ability to …

Consent For Emergency Treatment: Emergency Department Patient Recall And Understanding, Ashley Lafountain

Scholarship in Medicine - All Papers

Informed consent is an important ethical and legal requirement that underlies the concept of patient autonomy. This prospective survey study was conducted to assess patient recall and understanding of consent for treatment in adult emergency department (ED) patients at an urban level 1 trauma center with annual volume of 95,000, Miami Valley Hospital. Out of a total 293 patients, most individuals reported only receiving a verbal explanation of the consent document (45%) or not reading the document at all (36%). About half of the patients recalled consenting to treatment (N=144, 49%) and over one third of patients could not recall …

Choosing A Second-Generation Antidepressant Using Demographic Characteristics And Clinical Symptoms Of Depression, Amanda Lin

Master of Public Health Program Student Publications

Depression is the sixth most costly health condition in the United States, and depression that does not respond to its first trial of antidepressant treatment adds an annual cost of $9,529 per person per year. Thus, choosing an effective starting antidepressant can decrease the overall cost of depression to society. A secondary analysis of data from the Collaborative Psychiatric Epidemiology Survey (CPES) was performed to create models that can predict the efficacy of second-generation antidepressants in treating sadness. Two sets of Principal Component Analyses (PCAs) and logistic regressions were performed on variables associated with patient demographics, clinical symptoms, past medical …

Description Of Race And Preterm Birth In Six Ohio Counties From 2013-2018, Kelly Trabue

Master of Public Health Program Student Publications

Objective: The purpose of this research was to describe preterm birth rates, and the risk of preterm birth among maternal race groups in Ohio, Cuyahoga County, Franklin County, Hamilton County, Lucas County, Montgomery County, and Summit County from 2013 to 2018. For the purpose of this study, preterm birth was defined as the live birth of a baby with a period of gestation less than 37 weeks. The maternal race groups were African American, White, and Other.

Methods: A descriptive analysis of retrospective data was conducted on 798,957 live births in Ohio over six years. The data was further divided …

Risk Factors For Pneumonia Following Rib Fractures, Brittany Bowers

Scholarship in Medicine - All Papers

Objective: Pneumonia is a known complication following rib fractures. The purpose of this study is to identify factors associated with the development of pneumonia following rib fractures. Methods: In this retrospective chart review, eligible participants included trauma patients with one or more rib fractures who were admitted to Miami Valley Hospital during 2012 through 2017. Variables studied included age, gender, injury severity score (ISS), mechanism of injury, smoking status, alcohol use, administration of influenza and pneumococcal vaccine, number and side of rib fracture(s), spirometer use, blood transfusion, and intravenous fluid administration.

Results: Among 78 cases and 74 controls, matched for …

Health Literacy: Approach To Colon Cancer In African Americans, Judith Jefferson-Gordon

Doctor of Nursing Practice Program Projects

Health literacy is vitally important for African-Americans (AA), with higher incidence and mortality rates of colon cancer compared to Caucasians nationally and in Ohio. Larrabee's Model for Change to EBP and Self -Efficacy Middle range nursing theory guided this DNP project. A retrospective chart review of AA patients with colon cancer was completed to determine types of teaching methods used by nurses during the clinical encounter. A convenience sample (8%) of AA patients received colon cancer care in the ambulatory setting at the healthcare facility in the Midwest. More than half were female and the remainder were male (65% vs. …

Social Buffering By Unfamiliar Adult Males In Periadolescent Guinea Pigs: The Effects On Hpa Axis Activity And Fos Induction In The Medial Prefrontal Cortex, Alexander Bertke

Browse all Theses and Dissertations

In the guinea pig, the ability of the mother’s presence to buffer hypothalamic-pituitary- adrenal (HPA) axis activation in her young during exposure to stressful stimuli has been well documented. Under similar testing conditions, other conspecifics (littermates, other adult females) are less effective in doing so. The effect does seem to wane with age but is still present to a significant degree in offspring approaching adolescence. However, we recently observed that an unfamiliar adult male buffered HPA axis activation and increased Fos expression in the prefrontal cortex of preweaning infants exposed to a novel enclosure at both 60 and 120 minutes …

Assessment Of Pseudo-Continuous Arterial Spin Labeling (Pcasl) Inter-Session Reliability In The Quantification Of Cerebral Perfusion, Mohammad Ahmad Awad

Browse all Theses and Dissertations

Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) technique used for measuring cerebral blood flow (CBF) in a completely non-ionizing and non invasive fashion. ASL is useful in perfusion studies on healthy adult & pediatric subjects, individuals who need multiple follow-ups, and patients with varying cerebrovascular diseases where changes in CBF can be used as an indicator of tissue viability. We used a variation of the ASL technique known as pseudo-continuous ASL (pCASL). This form of ASL is the clinical standard (Alsop et al., 2015). However, it is not well documented the that pCASL is reliable between sessions …

Effect Of Hybrid/Complex N-Glycosylation On Cardiac Voltage-Gated Ion Channel Expression, Austin R. Parrish

Browse all Theses and Dissertations

Dilated cardiomyopathy (DCM) is one the most common forms of heart failure, with the majority of cases being idiopathic. Dr. Bennett’s laboratory previously showed that deletion of the Mgat1 gene in cardiomyocytes only (Mgat1KO) is sufficient to cause DCM leading to heart failure and early death. The Mgat1 gene product, GlcNAcT1, is responsible for initiating the formation of hybrid/complex N-glycosylation. These data suggest a link between abnormal glycosylation and heart disease; however, there is a mystery of how the specific changes in glycosylation contribute to heart disease etiology and progression. The proper function and gating of voltage-gated Na+ channels (Nav) …

Calpain-Calpastatin System In Peripheral Nerve Myelination And Demyelination, Domenica Elizabeth Drouet Saltos

Browse all Theses and Dissertations

Myelin is the structure formed by glial cells that electrically insulates axons aiding in propagation of action potentials. Disruption of myelin sheath (demyelination) is common to neurological diseases, such as multiple sclerosis (MS). The calcium-dependent protease, calpain, is known to modulate myelination during central nervous system (CNS) development. Endogenous calpain inhibitor, calpastatin, regulates calpain activity. The calpain-calpastatin system has been implicated in the CNS demyelination occurring in diseases. Charcot-Marie-Tooth disease (CMT) is a hereditary demyelinating polyneuropathy affecting proper functioning of peripheral nerves, demonstrating the importance of myelin in the peripheral nervous system (PNS). However, calpain’s role in the mechanism(s) of …

Calcium Imaging Of Developing Proprioceptive Dorsal Root Ganglion Neurons, Kaitlyn Louise Parkes

Browse all Theses and Dissertations

Proprioception is an important sensation capable due to proprioceptive sensory neuron afferents found in muscles in the periphery being processed by the central nervous system. The nervous system is a complex system that continues to develop and mature as an animal ages. Much is not known of proprioceptive neurons and how they develop with time. Calcium is an important molecule in maintaining action potentials and homeostasis in neurons which can be studied to understand a variety of things about a neuron. This study uses genetically encoded calcium indicators to tag parvalbumin positive cells in the dorsal root ganglion (DRG) in …

Diagnosing And Treating Diabetes In Rural Jamaica, Emily C. Sims

Scholarship in Medicine - All Papers

Objective: This research study was conducted to determine the correlation between finger stick glucose and finger stick hemoglobin A1c values in order to draw conclusions about the redundancy of the two tests in a rural Jamaican traveling clinic setting. Methods: This study was conducted using de-identified data from an electronic health record used in clinics in St. Mary’s Parish, Jamaica. A correlational analysis was completed using the glucose and A1c variables to determine both the direction and strength of the correlation. Results: A positive correlation of 0.654549 was found in analysis. This correlation did not meet the set threshold for …

A Closer Look At The Items Within Three Measures Of Evolution Acceptance: Analysis Of The Mate, I-Sea, And Gaene As A Single Corpus Of Items, William L. Romine, Amber Todd, Emily M. Walter

Medical Education Faculty Publications

Background: Current direct Likert measures for evolution acceptance include the MATE, GAENE, and I-SEA. Pros and cons of each of these instruments have been debated, and yet there is a dearth of research teasing out their similarities and differences when they are used together in a single context beyond the fact that their measures tend to be highly correlated. We administered these to 452 college students in non-major biology classes at two research-intensive universities from the Midwestern and Western United States to investigate the measurement properties of the items within these instruments when combined as a single corpus.Results: Factor analysis …

Lakeshore Modification Reduces Secondary Production Of Macroinvertebrates In Littoral But Not Deeper Zones, Marlene Pätzig, Yvonne Vadeboncoeur, Mario Brauns

Biological Sciences Faculty Publications

Littoral macroinvertebrates are an integral component of lake food webs, but their productivity may be affected by shoreline alteration. We hypothesized that human modification of lake shores simplifies habitat diversity, which, in turn, affects littoral macroinvertebrate production and patterns of depth–production relationships. Furthermore, we expected that lakeshore modification would favor nonnative species, potentially compensating for negative effects of lakeshore modification on production of native taxa. To test these ideas, we estimated benthic macroinvertebrate production in the upper littoral, middle littoral, and profundal zones of a large lowland lake (Lake Scharmützelsee) in Northeast Germany. We collected samples between April and November …

Pharmacists’ Knowledge Of Social Determinants Of Health In Post-Graduate Pharmacy Residency Programs, Rachel N. Chandra

Master of Public Health Program Student Publications

Background: Clinical pharmacists and their training programs can play a key role in helping to address social determinants of health (SDoH) by transforming healthcare beyond the traditional clinical approaches. Pharmacists’ knowledge of SDoH in post-graduate residency programs are key skills necessary for creating an impact in healthcare outcomes.

Purpose: The purpose of this project was to assess U.S. Department of Veterans Affairs (VA) post-graduate residency program directors’ and residents’ knowledge about SDoH. Methods: An IRB exempt questionnaire was created via Survey Monkey (™) and administered to postgraduate pharmacy residents (N = 618) and residency program directors (RPDs) (N = 235) …

Boonshoft School Of Medicine Central Research Forum Program - 2018, Office Of Research Affairs, Boonshoft School Of Medicine

Central Research Forum

The 63-page program includes a schedule, speaker biographies, and presentation titles from the 2018 Central Research Forum held by the Boonshoft School of Medicine's Office of Research Affairs.

Moderate Exercise Enhances Endothelial Progenitor Cell Exosomes Release And Function, Chunlian Ma, Jinju Wang, Hua Liu, Yanyu Chen, Xiaotang Ma, Shuzhen Chen, Yanfang Chen, Ji Chen Bihl, Yi Yang

Pharmacology and Toxicology Faculty Publications

Purpose: Exercise has cardiovascular benefits which might be related to endothelial progenitor cells (EPC). Meanwhile, there is evidence suggesting that EPC-derived exosomes (EPC-EX) promote vascular repair and angiogenesis through their carried microRNA (miR)-126. In this study, we investigated whether exercise could increase the levels of circulating EPC-EX and their miR-126 cargo, and by which promote the protective function of EPC-EX on endothelial cells (EC). Methods: Plasma EPC-EX from sedentary, low, or moderate exercise mice, respectively, denoted as EPC-EXS, EPC-EXL, and EPC-EXM, were isolated using microbead-based sorting techniques and characterized by nanoparticle tracking analysis, Western blot, and quantitative real-time polymerase chain …

The Learning Loss Effect In Genetics: What Ideas Do Students Retain Or Lose After Instruction?, Amber Todd, William L. Romine

Biological Sciences Faculty Publications

Modern genetics is a relatively new domain, but it is increasingly important for students to have a firm grasp on the content, because genetic technologies are becoming more commonplace. In a previous study, we used the Learning Progression-based Assessment of Modern Genetics to assess high school students’ knowledge of genetics concepts after an intensive inquiry-based genetics instructional period. Given that this type of intensive inquiry-based instruction is unique, we are now investigating how students’ knowledge of genetics changes after instruction (i.e., learning loss effect). Using a six-measure longitudinal design, we found that students retained significant gains in five of the …

Evidence-Based Practice Change Proposal: Implementation Of A Transition To Practice Program For New Registered Nurse Graduates Beginning Practice In An Extended Care Facility, Gwendolyn A. Stevenson

Doctor of Nursing Practice Program Projects

The transition to practice (TTP) of new registered nurses has long been a concept of interest within the nursing profession as unsuccessful transition to practice impacts individual nurses, healthcare organizations, the nursing profession, and the quality of patient care. There has been a renewed focus on transition to practice as changes in the healthcare delivery system and nursing profession have highlighted the importance of successful TTP in ensuring quality patient care in all settings. With an increasing geriatric population and healthcare delivery shifting away from acute care settings, greater numbers of new registered nurse graduates are transitioning to practice in …

New Functions For The Proprioceptive System In Skeletal Biology, Ronen Blecher, Lia Heinemann-Yerushalmi, Eran Assaraf, Nitzan Konstantin, Jens R. Chapman, Timothy C. Cope, Guy S. Bewick, Robert W. Banks, Elazar Zelzer

Neuroscience, Cell Biology & Physiology Faculty Publications

Muscle spindles and Golgi tendon organs (GTOs) are two types of sensory receptors that respond to changes in length or tension of skeletal muscles. These mechanosensors have long been known to participate in both proprioception and stretch reflex. Here, we present recent findings implicating these organs in maintenance of spine alignment as well as in realignment of fractured bones. These discoveries have been made in several mouse lines lacking functional mechanosensors in part or completely. In both studies, the absence of functional spindles and GTOs produced a more severe phenotype than that of spindles alone. Interestingly, the spinal curve phenotype, …

Repetitive Transcranial Electrical Stimulation Induces Quantified Changes In Resting Cerebral Perfusion Measured From Arterial Spin Labeling, Matthew Sherwood, Aaron T. Madaris, Casserly R. Mullenger, R. Andy Mckinley

Neuroscience, Cell Biology & Physiology Faculty Publications

The use of transcranial electrical stimulation (TES) as a method to augment neural activity has increased in popularity in the last decade and a half. The specific application of TES to the left prefrontal cortex has been shown to produce broad cognitive effects; however, the neural mechanisms underlying these effects remain unknown. In this work, we evaluated the effect of repetitive TES on cerebral perfusion. Stimulation was applied to the left prefrontal cortex on three consecutive days, and resting cerebral perfusion was quantified before and after stimulation using arterial spin labeling. Perfusion was found to decrease significantly more in a …

The Bello Chavez Family: A Reflection Of Health In The Mexican American Community Through A Family Nursing Assessment, Vanessa Bello Chavez

Best Integrated Writing

Vanessa Bello Chavez provides an in-depth, personal look into the health problems that affect Hispanic families across the United States. The writing takes a personal view and makes it relatable to all.

Best Integrated Writing 2018 - Complete Edition

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University. The journal is published annually by the Wright State University Department of English Language and Literatures.

Quantifying Photodamage By Noninvasive Mesoscopic Skin Imaging, Christina E. Borchers, Trevor Bihl, Chien Poon, Daniel J. Rohrbach, Samia Borchers, Julian Trevino, Max Rubin, Heidi Donnelly, Karl Kellawan, Lydia Carpenter, Shalini Bahl, Craig Rohan, Elizabeth Muennich, Scott Guenther, Holly Hahn, Ali Rkein, Marc Darst, Nico Mousdicas, Jeffery B. Travers, Ulas Sunar

Dermatology Faculty Publications

Ultraviolet light exposure is the major cause for photodamage. Pathologic effects of UVradiation include precancerous actinic keratosis which can progress into squamous cellcarcinoma. UV exposures commonly encountered include sunlight and indoor tanning bedexposure. Actinic neoplasia (precancerous actinic keratosis and non-melanoma skincancer) are highly prevalent in elderly patients with fair skin, and those with lower immunesystems. The impact on our healthcare system is substantial, as currently the averageannual cost to treat non-melanoma skin cancer is 5 billion dollars [1]. Though often asource of considerable morbidity due to extensive surgical procedures to remove the skincancers in the normal populations, squamous cell carcinomas …

Gender- And Region-Specific Changes In Estrogen Signaling In Aging Rat Brain Mitochondria, Christopher M. Evola, Tanner L. Hudson, Luping Huang, Adrian M. Corbett, Debra A. Mayes

Neuroscience, Cell Biology & Physiology Faculty Publications

Recently epidemiological studies suggest females lose neuroprotection from neurodegenerative diseases as they go through menopause. It has been hypothesized that this neuroprotection is hormone‐dependent. The current study characterized cell signaling molecules downstream of estrogen receptor beta that are known to play a role in memory, PKC, ERK, and connexin‐43, in regions of the brain associated with memory decline in an attempt to elucidate significant changes that occur post‐estrus. Total whole cell lysates were compared to isolated mitochondrial protein because mitochondrial function is known to be altered during aging. As hypothesized, protein concentrations differed depending on age, gender, and brain region. …

Department Of Surgery Update, August 2018, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, and more.

Volitional Down-Regulation Of The Primary Auditory Cortex Via Directed Attention Mediated By Real-Time Fmri Neurofeedback, Matthew Sherwood, Jason G. Parker, Emily E. Diller, Subhashini Ganapathy, Kevin B. Bennett, Jeremy T. Nelson

Neuroscience, Cell Biology & Physiology Faculty Publications

The present work assessed the efficacy of training volitional down-regulation of the primary auditory cortex (A1) based on real-time functional magnetic resonance imaging neurofeedback (fMRI-NFT). A1 has been shown to be hyperactive in chronic tinnitus patients, and has been implicated as a potential source for the tinnitus percept. 27 healthy volunteers with normal hearing underwent 5 fMRI-NFT sessions: 18 received real neurofeedback and 9 sham neurofeedback. Each session was composed of a simple auditory fMRI followed by 2 runs of A1 fMRI-NFT. The auditory fMRI alternated periods of no auditory with periods of white noise stimulation at 90 dB. A1 …

Health Care Provider Personal Religious Preferences And Their Perspective On Advance Care Planning With Patients, Marjorie A. Bowman, Sarah St. Cyr, Adrienne Stolfi

Population and Public Health Sciences Faculty Publications

Objective:

To understand how health-care providers’ (HCPs) religious preferences influence their willingness to undertake advance care planning (ACP) with patients and their acceptance of other HCP’s involvement.

Methods:

Online anonymous survey distributed to HCPs in hospital, ambulatory offices, and hospice settings in Dayton, Ohio. We evaluated the associations of HCP religion with their personal ACP, willingness to facilitate ACP, and acceptance of other HCPs’ ACP participation.

Results:

704 respondents: nurses (66.2%), physicians (18.8%), other HCPs (15.0%), white (88.9%), and primarily Catholic (23.3%) or Protestant (32.0%). “No religion” was marked by 13.9%. Respondents were favorable to ACP with patients. Religious respondents …

Adaptive Divergence In A Defense Symbiosis Driven From The Top Down, Jeremy J. Heath, Patrick Abbot, John O. Stireman Iii

Biological Sciences Faculty Publications

Most studies of adaptive radiation in animals focus on resource competition as the primary driver of trait divergence. The roles of other ecological interactions in shaping divergent phenotypes during such radiations have received less attention. We evaluate natural enemies as primary agents of diversifying selection on the phenotypes of an actively diverging lineage of gall midges on tall goldenrod. In this system, the gall of the midge consists of a biotrophic fungal symbiont that develops on host-plant leaves and forms distinctly variable protective carapaces over midge larvae. Through field studies, we show that fungal gall morphology, which is induced by …