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First Annual Research Symposium Program With Abstracts, Office Of Research Affairs, Boonshoft School Of Medicine

Boonshoft School of Medicine Research Symposium

The program booklet is a compilation of abstracts from oral and poster presentations at Wright State University's First Annual Boonshoft School of Medicine Medical Research Symposium held on April 6, 2022.

Beyond Trauma-Informed Care: Insights From A Qualitative Study, Danielle Gainer, Sydney Silverstein, Josef Rivera, Raminta Daniulaityte

Psychiatry Faculty Publications

Background: The impact of opioid use disorder (OUD) upon communities across the United States remains at epidemic levels, with a record number of overdose deaths recorded in 2020. As many communities have responded to this ongoing crisis with evidence-based treatment, harm reduction interventions and pharmacotherapy, recent efforts have focused on trauma-informed approaches to SUD care, taking into account the high prevalence of Adverse Childhood Experiences and related trauma in the lives of people living with OUD (Felliti, 1998; Stein, 2017). However, experiences of trauma and the manifestations of trauma in contemporary experience are never uniform (Maté, 2009). Qualitative research among …

Virtual Is Now Reality: Telehealth To Deliver Care For Substance Use Disorders, Brian Merrill, Danielle Gainer, Brent Schnipke

Psychiatry Faculty Publications

Models of care for substance use disorder (SUD) treatment have traditionally required face-to-face visits, since individuals receive a broad range of services including individual psychotherapy, group therapy, urine drug screens, laboratory testing, dispensation of Medications for Opioid Use Disorder (MOUD), and prescriptions for psychotropic or other medications. However, during the COVID-19 pandemic, telehealth became a more widely used method of delivering healthcare, including for SUD treatment. While the pandemic posed respiratory health concerns to all, individuals with a SUD were additionally vulnerable when attempting to access life-saving medications. An enforcement waiver of both federal and state telehealth rules during the …

The Relationship Between Screen Time, Weight Status, And Fatty Liver Disease In U.S. Adolescents, A Cross-Sectional Study Using Nhanes, 2017-2018, Becky J. Thomas

Master of Public Health Program Student Publications

Objective: The purpose of this study was to assess if screen time in U.S. adolescents is positively associated with evidence of fatty liver disease (steatosis and/or fibrosis) on FibroScan technology and to test the hypothesis that being overweight or obese mediates this relationship.

Methods: The analysis used cross-sectional data from 12–17-year-old participants (n = 612) in the 2017-2018 National Health and Nutrition Examination Survey (NHANES) to evaluate the association between self-reported average daily screen time and the presence of liver steatosis and/or fibrosis using FibroScan. Adjusted logistic regression analysis was performed to describe the independent association between screen time and …

Fungal Burden Of Disease In Central And South America, Urmimala Chaudhuri

Master of Public Health Program Student Publications

Background: Serious fungal infections are associated with an increase in mortality. Globally, fungal infections affect high-risk groups such as individuals with HIV/AIDS, asthma, transplant recipients, and those on immunosuppression. The most common fungal diseases include Histoplasmosis, Pneumocystis pneumonia (PCP), Candidiasis, and Allergic bronchopulmonary aspergillosis (ABPA). Epidemiological information on the prevalence of fungal diseases has been limited, particularly in Central and South America due to inadequate surveillance. Purpose: The aim of this review was to evaluate the burden of common fungal diseases in Central and South America and discuss strategies of national surveillance. Methods: PubMed searches were conducted from the years …

Variation In Student Perceptions Of Higher Education Course Quality And Difficulty As A Result Of Widespread Implementation Of Online Education During The Covid-19 Pandemic, Joseph Cavanaugh, Stephen J. Jacquemin, Christine Junker

Biological Sciences Faculty Publications

The onset of the COVID-19 global pandemic affected higher education in a myriad of ways. One of the most notable effects however was the rapid and sudden transition of nearly all courses at most institutions to an online environment. And while there are a growing number of courses offered online already, this transition to nearly 100% remote education presented numerous challenges for instructors and students of face-to-face and hybrid style courses. Since student perceptions are closely tied to recruitment and retention, it is important to know if there are differences in student perceptions present in the way different courses are …

In-Silico Determination Of Phytochemicals Against Spike Protein Of Covid-19, Muhammad Irfan, Muhammad Adil, Areej Fatima, Arooj Fatima, Ammara Khalid, Muhammad Bilal

Journal of Bioresource Management

Spike protein is present on the exterior of SARS-CoV-2 that mediates the binding of virus with human ACE2 receptor. S-protein has the ability to mutate in a short span of time. Using S-protein as a therapeutic target, Covid-19 infection can be prevented. Many plant-derived phytochemicals are found effective to treat viral infections. In this study, we selected top 10 phytochemicals following the Lipinski’s rule of five from total 82 candidate phytochemicals. The binding energies were determined through molecular docking of the phytochemical ligands. Top three compounds having maximal interactions and lowest binding energies were visualized. We suggested Dictamnine, Deoxypodophyllotoxin and …

Microbiological Contamination Associated With The Proximity Of A Refuse Dumpsite To A River Situated In Okada, Edo State, Nigeria, Ebere J. Okafor-Elenwo, Odaro S. Imade, Osazee E. Izevbuwa

Journal of Bioresource Management

This study was performed to evaluate the potential contamination of the Okponha river situated near a dumpsite in Okada, Edo State, Nigeria. Water samples were collected and analyzed for bacteriological and parasitological quality using standard procedures. Isolation and enumeration of bacterial colonies were performed by pour plate technique and the isolated bacteria were identified by standard phenotypic tests. Helminths and protozoa were screened by the direct smear technique. The values of HPC (3.79 ± 0.12 log₁₀ CFU/ml) and TCC (2.20 ± 0.14 log₁₀ CFU/ml) obtained from the river water samples exceeded WHO and NAFDAC recommended limits (≤ 2 …

Current Epidemiological Status And Antibiotic Resistance Profile Of Urinary Tract Infection, Muddasir Khan, Syed Hussain Shah, M. Abdullah, Muhammad Salman, Fawad Hayat, Raheela Sarwar, Neelma Hassan, Sohail Ahmad Jan, M. Saddam, Ziaur Rahman, Imran Qazi

Journal of Bioresource Management

With a longitudinal (2020–2021) completion, a set of 300 urine samples of individuals suspected of UTI was characterized based on the biochemical analysis and Kirby Bauer's disc diffusion method. Throughout, a total of 167 samples revealed UTI positivity by obtaining bacterial growth. Reporting that E. coli (69.4 %) was the most dominant when compared with Klebsiella (14.3 %), Proteus (5.9 %), S. aureus (4.7 %), P. aeruginosa (3.5 %), and Enterobacter (1.7 %), respectively. Gender-wise discrimination showed that E. coli was highly distributed among female (50.2 %) patients. A prominent percentage of E. coli (41.9 %) was found in the …

Metabolic Bone Disease Of Infancy In The Offspring Of Mothers With Bariatric Surgery: A Series Of 5 Infants In Contested Cases Of Child Abuse, Marvin E. Miller, David Ayoub

Pediatrics Faculty Publications

Background and aims: Metabolic Bone Disease of Infancy is a multifactorial disorder of bone fragility in infants who typically present under 6 months of age with multiple unexplained fractures. Major risk factors for this disorder relate to the fetal time period and include decreased provision of the essential nutrients for bone formation during pregnancy (calcium, phosphate, vitamin D, and protein), prema- turity, and decreased fetal bone loading. Methods: This study presents 5 infants with multiple unexplained fractures born to women who had prior bariatric surgery in which child abuse was alleged, and the alleged perpetrator denied wrong doing. Results: The …

John Lyman Interview For The Boonshoft School Of Medicine 50th Anniversary Oral History Project, John Lyman, Kristen Dilger

Boonshoft 50th Anniversary Oral History Project

Kristen Dilger interviews John Lyman, a graduate of the Boonshoft School of Medicine. He worked in emergency medicine until his retirement where he works part-time doing occupational health. Part of the class of 1980, Lyman discusses his collegiate career, including why he chose Wright State University's new medical college and talks about what it was like attending the college. He talks about the challenges and processes of attending a new medical college, and how attending the Wright State University Boonshoft School of Medicine assisted him in his early career.

The Anti-Inflammatory Agent Bindarit Attenuates The Impairment Of Neural Development Through Suppression Of Microglial Activation In A Neonatal Hydrocephalus Mouse Model, Eri Iwasawa, Farrah N. Brown, Crystal Shula, Fatima Kahn, Sang Hoon Lee, Temugin Berta, David R. Ladle, Kenneth Campbell, Francesco T. Mangano, June Goto

Neuroscience, Cell Biology & Physiology Faculty Publications

Neonatal hydrocephalus presents with various degrees of neuroinflammation and long-term neurologic deficits in surgically treated patients, provoking a need for additional medical treatment. We previously reported elevated neuroinflammation and severe periventricular white matter damage in the progressive hydrocephalus (prh) mutant which contains a point mutation in the Ccdc39 gene, causing loss of cilia-mediated unidirectional CSF flow. In this study, we identified cortical neuropil maturation defects such as impaired excitatory synapse maturation and loss of homeostatic microglia, and swimming locomotor defects in early postnatal prh mutant mice. Strikingly, systemic application of the anti-inflammatory small molecule bindarit significantly supports healthy …

Robert Brandt Interview For The Boonshoft School Of Medicine 50th Anniversary Oral History Project, Robert Brandt, Kristen Dilger

Boonshoft 50th Anniversary Oral History Project

Kristen Dilger interviews Robert Brandt, a graduate of the Boonshoft School of Medicine. He worked in Family Medicine as both a primary care physical and HIV/AIDS specialist, along with his role as a clinical professor for the Boonshoft School of Medicine until his retirement in 2018. Part of the class of 1980, Brandt discusses his collegiate career, including why he chose Wright State University's new medical college and talks about what it was like attending the college. He talks about the challenges and processes of attending a new medical college, and how attending the Wright State University Boonshoft School of …

Toward An Ontology Of Collaborative Learning Healthcaresystems, Alexandra H. Vinson, Michael Seid, Breck Gamel, Shehzad Ahmed Saeed, Brandy Fureman, Susan C. Cronin, Katherine Bates, David Hartley

Pediatrics Faculty Publications

Objective:To establish a basis for a domain ontology - a formal, explicit specificationof a shared conceptualization - of collaborative learning healthcare systems (CLHSs)in order to facilitate measurement, explanation, and improvement.Methods:We adapted the“Methontology”approach to begin building an ontologyof CLHSs. We specified the purpose of an ontology, acquired domain knowledge vialiterature review, conceptualized a common framework of CLHSs using a groundedapproach, refined these concepts based on expert panel input, and illustrated con-cept application via four cases.Results:The set of concepts identified as important to include in an ontologyincludes goals, values, structure, actors, environment, and products. To establish thisset of concepts, we gathered input …

Phil Cusumano, M.D. Interview For The Boonshoft School Of Medicine 50th Anniversary Oral History Project, Phil Cusumano, Kristen Dilger

Boonshoft 50th Anniversary Oral History Project

Kristen Dilger interviews Dr. Phil Cusumano, a graduate of the Boonshoft School of Medicine and has recently transitioned from primary care to addiction medicine at the time of the interview. Part of the class of 1983, Cusumano discusses his collegiate career, including why he chose Wright State University's new medical college and talks about what it was like attending the college. He talks about the challenges and processes of attending a new medical college, and how attending the Wright State University Boonshoft School of Medicine assisted him in his early career.

Michael Oleksyk Interview For The Boonshoft School Of Medicine 50th Anniversary Oral History Project, Michael Oleksyk, Kristen Dilger

Boonshoft 50th Anniversary Oral History Project

Kristen Dilger interviews Michael Oleksyk, a graduate of the Boonshoft School of Medicine. Retired, he works part-time as a hospitalist at Gulf Coast Medical Center. Part of the class of 1983, Oleksyk discusses his collegiate career, including why he chose Wright State University's new medical college and talks about what it was like attending the college. He talks about the challenges and processes of attending a new medical college, and how attending the Wright State University Boonshoft School of Medicine assisted him in his early career.

A Statistical Analysis Of Poverty Indicators On The Opioid Crisis In Ohio, Calsey Graham, Alex Shiplett

Scholarship in Medicine - All Papers

Objective: Our objective was to identify the effect poverty has on rates of opioid overdose in Ohio counties. Based on previous research, we determined our indicators of poverty to examine were: median-household income, rates of children in free lunch programs, and residential segregation. Utilizing data from both Ohio counties and the state of California, we investigated how our indicators of poverty influenced drug overdose deaths in order to provide public health directives going forward. Methods: We utilized County Health records that combined multiple outlets to retrieve the necessary data to compare rates of poverty and opioid overdose in Ohio’s counties. …

Patient-Centered Focus Groups As A Catalyst For Anti-Racism Research And Quality Improvement In An Urban Academic Ob/Gyn Clinic, Samantha Brenner, Fiona Hodges, Tonia J. Rhone, Toni Tipton, Keith Reisinger-Kindle

Obstetrics and Gynecology Faculty Publications

Background •There is a known, pervasive existence of racism within OBGYN with resultant inequities and disparities in patient outcomes •Limited published perspectives of patients with racism in inpatient and outpatient OBGYN •The importance of centering patients’ voices in anti-racism research initiatives is clear •The objective of this study was to utilize patient-centered focus groups to prioritize anti-racism quality improvement and research investigations in the inpatient and outpatient setting

Correlating Measles Cases And Vaccination Rates In The United States And Abroad, Charu L. Gupta

Scholarship in Medicine - All Papers

Introduction: Measles is a highly contagious and vaccine-preventable viral respiratory infection that continues to affect children and adults in the United States (U.S.) and abroad. Objective: This study aims to correlate vaccination rates and measles cases in the U.S. to countries worldwide during 1995 to 2000 and 2013 to 2018. Methods: Two datasets, measles reported cases and percent single dose measles-containing-vaccine coverage in 1-year old infants, were obtained from World Health Observatory Data portal for 165 countries. Third dataset, population dynamics, was utilized from World Bank portal to convert reported measles cases to measles case rates for selected 165 countries. …

Novel Repair Of Costal Margin Rupture With Preoperative 3d Planning, Casey T. Walk, Gregory Semon

Department of Surgery Faculty Publications

WHAT WOULD YOU DO? This is a 32-year-old man involved in a motor vehicle crash in 2019 with chronic left-sided rib pain since. He was initially treated with physical therapy and medical management with no improvement. CT imaging in 2021 noted displaced left lateral seventh and eighth ribs, noted chest wall deformity, and when three-dimensional (3D) reconstruction of his ribs was created, this noted a left- sided costal margin rupture at the sixth and seventh ribs.

A Retrospective Cohort Study Assessing Acute Kidney Injury And Renal Recovery Among Septic Patients Empirically Treated With Vancomycin Piperacillin–Tazobactam Versus Vancomycin Cefepime, Brian Pacca Elliott, Michael M. Tang, Joshua Alexander Madden, Ronald J. Markert, Steven Dale Burdette, Craig Matthew Pleiman, Emily Claire Speelmon

Internal Medicine Faculty Publications

Vancomycin plus piperacillin-tazobactam (VPT) is a commonly used antimicrobial regimen for septic patients. VPT is more nephrotoxic than other regimens such as vancomycin plus cefepime (VC) when given over several days. This risk of nephrotoxicity is less clear when VPT is given for initial empiric therapy in sepsis and de-escalated quickly based on evolving clinical information. The objective of this study was to assess nephrotoxicity among septic patients empirically treated with either VPT or VC at initial clinical presentation. We conducted a retrospective study of septic patients who received VPT or VC within 12 h of presentation to the emergency …

Whistling Scrotum: An Unusual Presentation Of Pneumomediastinum In The Setting Of An Open Scrotal Wound, Brant Bickford, Andrew J. Berglund, Ronald J. Markert, Hari Polenakovik

Internal Medicine Faculty Publications

BACKGROUND Pneumoscrotum is a rare clinical occurrence in which air accumulates in the scrotum. The origin of air is primarily from trauma, but spontaneous pneumoscrotum can develop from gastrointestinal or pulmonary sources. Physical examination of pneumoscrotum typically includes crepitus of the perineal region and scrotal swelling and associated findings depending on the origin of the free air. However, pneumoscrotum in the setting of a scrotal wound, which allows air to pass freely outside the body, has not been previously documented in the literature. CASE REPORT A 72-year-old man who recently underwent a scrotal incision and drainage for recurrent epididymitis presented …

The Interaction Of Children Living In Single-Parent Households With Healthcare In Tennessee, Molly Balcer

Scholarship in Medicine - All Papers

The objective of this paper is to examine how a child living in a single-parent home is able to interact with healthcare in the state of Tennessee in 2020. Family structure in the United States trends away from the nuclear family, with 32% of households containing children headed by single-parents in 2018 as recorded by the United States Census Bureau. Given the knowledge that children in single-parent families are at higher risk for unmet healthcare needs, it is prudent to determine whether these trends are mirrored in Tennessee. Tests of statistical analysis were conducted on publicly available data collected from …

Factors Affecting The Rates Of Childhood Poverty In Tennessee, Aleeya F. Shareef

Scholarship in Medicine - All Papers

Objective: The goal of this investigation is to analyze data to determine the factors that influence childhood poverty in Tennessee. Specifically, I am examining how child poverty has changed over the past years, as well as determining its associations with residential segregation (Black/white), food insecurity, teen births, low birthweights, child and infant mortalities, drug overdose deaths, access to healthy foods, premature deaths, and uninsured children. Data was used from the County Health Rankings website. Their data has been collected from surveys. Paired t-tests, unpaired t-tests, Pearson correlations, and stepwise linear regressions were performed. Results indicated that Tennessee has had decreased …

Relationship Between Poverty And Ed Visit Rate (Per 10,000) With Primary Diagnosis Of Asthma Amongst Ohio Counties, Emily Schneider

Scholarship in Medicine - All Papers

Objective: Previous literature have found mixed results regarding poverty as a risk factor for asthma prevalence. More recently, national data obtained from Medicaid has shown that there is no association between poverty and asthma prevalence but has shown an association with asthma-related Emergency Department (ED) visits and hospitalizations. The objective of this study is to determine if this relationship is evident amongst the 88 counties in Ohio. Methods: Pearson correlations were conducted with the following variables: percent in poverty under age 18 and the ED visit rate with a primary diagnosis of asthma amongst children in each Ohio county. This …

Self- Vs Provider-Referral Differences For Coronary Artery Calcium Testing, Rebekah Lantz, Steve Young, Janet Lubov, Anas Ahmed, Ronald J. Markert, Srikanth Sadhu

Internal Medicine Faculty Publications

Study objectives: The objectives of this study were to identify independent predictors for moderate/accentuated coronary artery calcium (CAC) score and compare patients who self-referred for CAC Computed Tomography (CT) testing to those who were provider-referred. Design: Patients underwent CAC between January to July 2019. The analysis was divided into self-referred patients influenced by a CAC community campaign who identified themselves as having cardiovascular risk factors compared to provider-referred intermediate-risk patients who were asymptomatic. SAS version 9.4 (SAS Institute, Inc., Cary, NC) was used for all analyses. Setting: Seven southwest Ohio hospitals from a single network. Participants: 2124 adult patients who …

The Effects Of Covid-19 On Staying Alive Nbme Performance And Exam Testing Conditions, Anh Phuong Nguyen

Scholarship in Medicine - All Papers

Objective: This study will study the impact of COVID-19 on Wright State University BSOM class of 2023’s performance on the SA NBME exam and whether there was a difference in the scores between the group who took the test at school compared to at home. Methods: independent samples t-test was used to analyze SA NBME exam scores from BSOM class of 2022 and class of 2023 (n = 231) and also from students in the class of 2023 who took the SA NBME from home and at school. Results: The class of 2023’s performance on the SA NBME exam …

Ameliorating Role Of Ulva Lactuca Extract On Neurobehavioral And Neurochemical Abnormalities Caused By Lithium In Rats, Samira Bouhalit, Noura Brahmi

Journal of Bioresource Management

Lithium is a relevant mood-stabilizing agent that is used in the management of depressive and manic episodes in bipolar, disorder; however, its application may cause diverse side effects including oxidative stress. This work investigated the neuroprotective and anti-stress activity of Ulva lactuca extract (MEUL) against lithium induced neuronal toxicity in rats. Lithium (2 g/kg) was administered in diets with or without MEUL (250 mg/kg BW by gavage) for 90 days. Lithium induced oxidative stress lead to an elevation in lipid peroxidation and oxidation protein product levels, a reduced superoxide dismutase, glutathione peroxidase activities, glutathione, and ascorbic acid concentrations in brain. …

A Review Of Globally Important Plant Origin Antioxidants And Their Folk Utility For Various Diseases, Nosheen Akhtar, Ali Nasir, Hanachi Paricheher

Journal of Bioresource Management

This review article has attempted to analyze the folk utility of important medicinal plants having valuable secondary metabolites used for the treatment of a variety of diseases. It is estimated that two-thirds of the total medicinal plants are used for the treatment of various diseases. Some medicinal plants are known for great antioxidant properties. Antioxidants reduce oxidative stress in cells. Antioxidants are useful for the treatment of cardiovascular diseases, inflammatory diseases, and cancers. This review article discloses the naturally occurring antioxidants and their sources. Medicinal plants with such a high potential of antioxidants have been part of folk medicine over …

Measuring Science Teachers' Emotional Experiences With Evolution Using Real World Scenarios, William Lee Romine, Rutuja Mahajan, Amber Todd

Biological Sciences Faculty Publications

Low acceptance of evolution remains an obstacle to quality biology instruction. We develop and utilize a novel assessment which measures emotional experience in light of real-world evolution education scenarios. We presented 296 science teachers 4 pro-evolution and 8 anti-evolution scenarios and asked them to rate their levels of joy, anger, sadness, fear, disgust, shame, and guilt elicited by that scenario on an ordinal 5-point scale. We used exploratory factor analysis to extract the most important dimensions in the teachers’ responses, Rasch analysis to explore the validity of the extracted subscales, and stepwise regression to find the most important factors driving …