Medicine and Health Sciences Commons^™

Prefrontal Cortex Supports Speech Perception In Listeners With Cochlear Implants, Arefeh Sherafati, Noel Dwyer, Aahana Bajracharya, Mahlega Samira Hassanpour, Adam T Eggebrecht, Jill B Firszt, Joseph P Culver, Jonathan E Peelle

2020-Current year OA Pubs

Cochlear implants are neuroprosthetic devices that can restore hearing in people with severe to profound hearing loss by electrically stimulating the auditory nerve. Because of physical limitations on the precision of this stimulation, the acoustic information delivered by a cochlear implant does not convey the same level of acoustic detail as that conveyed by normal hearing. As a result, speech understanding in listeners with cochlear implants is typically poorer and more effortful than in listeners with normal hearing. The brain networks supporting speech understanding in listeners with cochlear implants are not well understood, partly due to difficulties obtaining functional neuroimaging …

Biophysical Physiology Of Phosphoinositide Rapid Dynamics And Regulation In Living Cells, Jill B Jensen, Bjoern H Falkenburger, Eamonn J Dickson, Lizbeth De La Cruz, Gucan Dai, Jongyun Myeong, Seung-Ryoung Jung, Martin Kruse, Oscar Vivas, Byung-Chang Suh, Bertil Hille

2020-Current year OA Pubs

Phosphoinositide membrane lipids are ubiquitous low-abundance signaling molecules. They direct many physiological processes that involve ion channels, membrane identification, fusion of membrane vesicles, and vesicular endocytosis. Pools of these lipids are continually broken down and refilled in living cells, and the rates of some of these reactions are strongly accelerated by physiological stimuli. Recent biophysical experiments described here measure and model the kinetics and regulation of these lipid signals in intact cells. Rapid on-line monitoring of phosphoinositide metabolism is made possible by optical tools and electrophysiology. The experiments reviewed here reveal that as for other cellular second messengers, the dynamic …

Identifying Colorectal Cancer Caused By Biallelic Mutyh Pathogenic Variants Using Tumor Mutational Signatures, Peter Georgeson, Yin Cao, Et Al

2020-Current year OA Pubs

Carriers of germline biallelic pathogenic variants in the MUTYH gene have a high risk of colorectal cancer. We test 5649 colorectal cancers to evaluate the discriminatory potential of a tumor mutational signature specific to MUTYH for identifying biallelic carriers and classifying variants of uncertain clinical significance (VUS). Using a tumor and matched germline targeted multi-gene panel approach, our classifier identifies all biallelic MUTYH carriers and all known non-carriers in an independent test set of 3019 colorectal cancers (accuracy = 100% (95% confidence interval 99.87-100%)). All monoallelic MUTYH carriers are classified with the non-MUTYH carriers. The classifier provides evidence for a …

Quantifying Concordant Genetic Effects Of De Novo Mutations On Multiple Disorders, Hanmin Guo, Lin Hou, Yu Shi, Sheng Chih Jin, Xue Zeng, Boyang Li, Richard P Lifton, Martina Brueckner, Hongyu Zhao, Qiongshi Lu

2020-Current year OA Pubs

Exome sequencing on tens of thousands of parent-proband trios has identified numerous deleterious de novo mutations (DNMs) and implicated risk genes for many disorders. Recent studies have suggested shared genes and pathways are enriched for DNMs across multiple disorders. However, existing analytic strategies only focus on genes that reach statistical significance for multiple disorders and require large trio samples in each study. As a result, these methods are not able to characterize the full landscape of genetic sharing due to polygenicity and incomplete penetrance. In this work, we introduce EncoreDNM, a novel statistical framework to quantify shared genetic effects between …

What Is The State Of Children's Participation In Qualitative Research On Health Interventions?: A Scoping Study, Jean M Hunleth, Julie S Spray, Corey Meehan, Colleen Walsh Lang, Janet Njelesani

2020-Current year OA Pubs

BACKGROUND: Children are the focus of numerous health interventions throughout the world, yet the extent of children's meaningful participation in research that informs the adaptation, implementation, and evaluation of health interventions is not known. We examine the type, extent, and meaningfulness of children's participation in research in qualitative health intervention research.

METHOD: A scoping study was conducted of qualitative published research with children (ages 6-11 years) carried out as part of health intervention research. Following Arksey and O'Malley's scoping study methodology and aligned with the PRISMA-ScR guidelines on the reporting of scoping reviews, the authors searched, charted, collated, and summarized …

Patched 1 Regulates Smoothened By Controlling Sterol Binding To Its Extracellular Cysteine-Rich Domain, Laurel Mydock-Mcgrane, Kathiresan Krishnan, Douglas F Covey, Et Al

2020-Current year OA Pubs

Smoothened (SMO) transduces the Hedgehog (Hh) signal across the plasma membrane in response to accessible cholesterol. Cholesterol binds SMO at two sites: one in the extracellular cysteine-rich domain (CRD) and a second in the transmembrane domain (TMD). How these two sterol-binding sites mediate SMO activation in response to the ligand Sonic Hedgehog (SHH) remains unknown. We find that mutations in the CRD (but not the TMD) reduce the fold increase in SMO activity triggered by SHH. SHH also promotes the photocrosslinking of a sterol analog to the CRD in intact cells. In contrast, sterol binding to the TMD site boosts …

Molecular Imaging Phenotyping For Selecting And Monitoring Radioligand Therapy Of Neuroendocrine Neoplasms, Amir Iravani, Ashwin Singh Parihar, Timothy Akhurst, Rodney J Hicks

2020-Current year OA Pubs

Neuroendocrine neoplasia (NEN) is an umbrella term that includes a widely heterogeneous disease group including well-differentiated neuroendocrine tumours (NETs), and aggressive neuroendocrine carcinomas (NECs). The site of origin of the NENs is linked to the intrinsic tumour biology and is predictive of the disease course. It is understood that NENs demonstrate significant biologic heterogeneity which ultimately translates to widely varying clinical presentations, disease course and prognosis. Thus, significant emphasis is laid on the pre-therapy evaluation of markers that can help predict tumour behavior and dynamically monitors the response during and after treatment. Most well-differentiated NENs express somatostatin receptors (SSTRs) which …

Optimizing Allocation Of Curricular Content Across The Undergraduate & Graduate Medical Education Continuum, Samara B Ginzburg, Margaret M Hayes, Brittany L Ranchoff, Eva Aagaard, Katharyn M Atkins, Michelle Barnes, Jennifer B Soep, Andrew C Yacht, Erik K Alexander, Richard M Schwartzstein

2020-Current year OA Pubs

BACKGROUND: Medical educators struggle to incorporate socio-cultural topics into crowded curricula. The "continuum of learning" includes undergraduate and graduate medical education. Utilizing an exemplar socio-cultural topic, we studied the feasibility of achieving expert consensus among two groups of faculty (experts in medical education and experts in social determinants of health) on which aspects of the topic could be taught during undergraduate versus graduate medical education.

METHODS: A modified Delphi method was used to generate expert consensus on which learning objectives of social determinants of health are best taught at each stage of medical education. Delphi respondents included experts in medical …

Macrophages Disseminate Pathogen Associated Molecular Patterns Through The Direct Extracellular Release Of The Soluble Content Of Their Phagolysosomes, Catherine J Greene, Jenny A Nguyen, Samuel M Cheung, Corey R Arnold, Dale R Balce, Ya Ting Wang, Adrian Soderholm, Neil Mckenna, Devin Aggarwal, Rhiannon I Campden, Benjamin W Ewanchuk, Herbert W Virgin, Robin M Yates

2020-Current year OA Pubs

Recognition of pathogen-or-damage-associated molecular patterns is critical to inflammation. However, most pathogen-or-damage-associated molecular patterns exist within intact microbes/cells and are typically part of non-diffusible, stable macromolecules that are not optimally immunostimulatory or available for immune detection. Partial digestion of microbes/cells following phagocytosis potentially generates new diffusible pathogen-or-damage-associated molecular patterns, however, our current understanding of phagosomal biology would have these molecules sequestered and destroyed within phagolysosomes. Here, we show the controlled release of partially-digested, soluble material from phagolysosomes of macrophages through transient, iterative fusion-fission events between mature phagolysosomes and the plasma membrane, a process we term eructophagy. Eructophagy is most active …

Synthesizing Pseudo-T2w Images To Recapture Missing Data In Neonatal Neuroimaging With Applications In Rs-Fmri, Sydney Kaplan, Dimitrios Alexopoulos, Jeanette K Kenley, Deanna M Barch, Jeffrey J Neil, Cynthia E Rogers, Aristeidis Sotiras, Christopher D Smyser, Et Al.

2020-Current year OA Pubs

T1- and T2-weighted (T1w and T2w) images are essential for tissue classification and anatomical localization in Magnetic Resonance Imaging (MRI) analyses. However, these anatomical data can be challenging to acquire in non-sedated neonatal cohorts, which are prone to high amplitude movement and display lower tissue contrast than adults. As a result, one of these modalities may be missing or of such poor quality that they cannot be used for accurate image processing, resulting in subject loss. While recent literature attempts to overcome these issues in adult populations using synthetic imaging approaches, evaluation of the efficacy of these methods in pediatric …

Horizontal Gene Transfer Provides Insights Into The Deep Evolutionary History And Biology Of Trichinella, Dante Zarlenga, Peter Thompson, Makedonka Mitreva, Bruce A Rosa, Eric Hoberg

2020-Current year OA Pubs

Evolution involves temporal changes in the characteristics of a species that are subsequently propagated or rejected through natural selection. In the case of parasites, host switching also plays a prominent role in the evolutionary process. These changes are rooted in genetic variation and gene flow where genes may be deleted, mutated (sequence), duplicated, rearranged and/or translocated and then transmitted through vertical gene transfer. However, the introduction of new genes is not driven only by Mendelian inheritance and mutation but also by the introduction of DNA from outside a lineage in the form of horizontal gene transfer between donor and recipient …

Pilot Feasibility Study Of A Simple Regenerative Peripheral Nerve Interface Designed To Diminish Cutaneous Dysesthesia After Supraclavicular Operations, Alexander Yang, Robert W Thompson

2020-Current year OA Pubs

Supraclavicular operations can be associated with postoperative cutaneous dysesthesia and hypersensitivity. Regenerative peripheral nerve interfaces, created by attaching the proximal end of a divided peripheral nerve into a viable muscle target, can promote neurite regrowth and neuromuscular connections to help suppress painful nerve hyperactivity. During 40 consecutive operations for neurogenic thoracic outlet syndrome, we demonstrated that division of at least one of the superficial supraclavicular cutaneous sensory nerve branches was necessary in 98% of cases. We subsequently developed a novel regenerative peripheral nerve interface for supraclavicular operations using the adjacent omohyoid muscle and have described the technical steps involved in …

Low Housing Quality, Unmet Social Needs, Stress And Depression Among Low-Income Smokers, Rachel Garg, Amy Mcqueen, Jennifer M Wolff, Karen E Skinner, Michelle C Kegler, Matthew W Kreuter

2020-Current year OA Pubs

Smokers are at greater risk of multiple health conditions that are exacerbated by environmental hazards associated with low housing quality. However, little is known about the prevalence of low housing quality among low-income smokers. Using correlations and logistic regression, we examined associations among eight housing quality indicators - pests, water leaks, mold, lead paint, and working smoke detectors, appliances, heating, and air conditioning - and between housing quality and social needs, depressive symptoms, perceived stress, sleep problems, and self-rated health in a community-based sample of 786 low-income smokers from 6 states. Most participants were female (68%), and White (45%) or …

Deceased Donor Procurement Biopsy Practices, Interpretation, And Histology-Based Decision-Making: A Survey Of Us Kidney Transplant Centers, Krista L. Lentine, Jason R. Wellen, Melissa Lichtenberger, Et Al.

2020-Current year OA Pubs

INTRODUCTION: The utility of kidney procurement biopsies is controversial. Understanding the current landscape of how clinicians obtain and use biopsies in organ evaluation may help inform consensus-building efforts.

METHODS: An electronic survey was distributed to clinicians at US kidney transplant programs (April 22, 2021-June 30, 2021) to evaluate donor biopsy indications, frequency, processing and interpretation, and impact of findings on practices.

RESULTS: Responses from staff involved in organ acceptance (73% surgeons, 20% nephrologists, 6% coordinators) at 95 transplant centers were analyzed, representing 40% of US transplant centers and 50% of recent deceased donor kidney transplant volume. More than a third …

Real-Time Motion Monitoring Improves Functional Mri Data Quality In Infants, Carolina Badke D'Andrea, Jeanette K Kenley, David F Montez, Amy E Mirro, Ryland L Miller, Eric A Earl, Jonathan M Koller, Sooyeon Sung, Essa Yacoub, Jed T Elison, Damien A Fair, Nico U F Dosenbach, Cynthia E Rogers, Christopher D Smyser, Deanna J Greene

2020-Current year OA Pubs

Imaging the infant brain with MRI has improved our understanding of early neurodevelopment. However, head motion during MRI acquisition is detrimental to both functional and structural MRI scan quality. Though infants are typically scanned while asleep, they commonly exhibit motion during scanning causing data loss. Our group has shown that providing MRI technicians with real-time motion estimates via Framewise Integrated Real-Time MRI Monitoring (FIRMM) software helps obtain high-quality, low motion fMRI data. By estimating head motion in real time and displaying motion metrics to the MR technician during an fMRI scan, FIRMM can improve scanning efficiency. Here, we compared average …

Depression And Anxiety Screening Identifies Patients That May Benefit From Treatment Regardless Of Existing Diagnoses, Brandon Lippold, Yash R. Tarkunde, Abby L. Cheng, Charles P. Hannon, Muyibat A. Adelani, Ryan P. Calfee

2020-Current year OA Pubs

BACKGROUND: This study investigated the utility of depression and anxiety symptom screening in patients scheduled for total knee arthroplasty to examine differences in active symptoms according to patients' mental health diagnoses and associated prescription medications.

MATERIAL AND METHODS: This cross-sectional study analyzed 594 patients scheduled for total knee arthroplasty at a tertiary practice between June 2018 and December 2018. Patients completed Patient-Reported Outcomes Measurements Information System (PROMIS) Depression and Anxiety Computerized Adaptive Tests in clinic quantifying active symptoms. Mental health diagnoses and associated medications were extracted from health records. Statistical analysis assessed between-group differences in mean PROMIS scores and the …

A Short-Term Multicenter Analysis Of Radiolucent Lines In A Single Uncemented Rotating Platform Implant For Total Knee Arthroplasty, Jason Desmarais, David Dalury, Thomas L. Bernasek, David A. Fisher, Ryan M. Nunley, Marie-Claire Fickenscher, Robert S Gorab

2020-Current year OA Pubs

BACKGROUND: Uncemented total knee arthroplasty is increasing as a potential solution for aseptic loosening via biologic fixation and to increase operative efficiency. However, postoperative radiolucent lines (RLLs) remain a concern for some clinicians. We report on a multicenter analysis of these RLLs over a 2-year period to identify their incidence, progression, and clinical significance.

MATERIAL AND METHODS: Institutional review board approval was obtained for this retrospective, multicenter case series. A total of 312 patients treated with a single cruciate-retaining, fully porous coated femoral and tibial component design were included in the study. All patients were evaluated clinically and radiographically in …

Sustained Effect Of Lactin-V (Lactobacillus Crispatus Ctv-05) On Genital Immunology Following Standard Bacterial Vaginosis Treatment: Results From A Randomised, Placebo-Controlled Trial, Eric Armstrong, Anke Hemmerling, Steve Miller, Kerianne E. Burke, Sara J. Newmann, Sheldon R. Morris, Hilary Reno, Sanja Huibner, Maria Kulikova, Nico Nagelkerke, Bryan Coburn, Craig R. Cohen, Rupert Kaul

2020-Current year OA Pubs

BACKGROUND: Bacterial vaginosis might increase HIV risk by eliciting genital inflammation and epithelial barrier disruption, whereas vaginal Lactobacillus crispatus is associated with immune quiescence and HIV protection. We investigated the effect of a live biotherapeutic containing L crispatus CTV-05 (LACTIN-V) on genital immunology and key vaginal bacteria.

METHODS: This substudy included women aged 18-45 years who participated in the randomised, placebo-controlled, phase 2b trial of LACTIN-V to reduce bacterial vaginosis recurrence, conducted at four universities and hospitals in the USA. Women with negative results for sexually transmitted infection, pregnancy, and urinary tract infection were provided a 5-day course of vaginal …

Mutation Spectrum Of Congenital Heart Disease In A Consanguineous Turkish Population, Weilai Dong, Hande Kaymakcalan, Sheng Chih Jin, Nicholas S Diab, Cansaran Tanıdır, Ali Seyfi Yalim Yalcin, A Gulhan Ercan-Sencicek, Shrikant Mane, Murat Gunel, Richard P Lifton, Kaya Bilguvar, Martina Brueckner

2020-Current year OA Pubs

BACKGROUNDS: While many studies agree that consanguinity increases the rate of congenital heart disease (CHD), few genome analyses have been conducted with consanguineous CHD cohorts.

METHODS: We recruited 73 CHD probands from consanguineous families in Turkey and used whole-exome sequencing (WES) to identify genetic lesions in these patients.

RESULTS: On average, each patient had 6.95 rare damaging homozygous variants, 0.68 of which are loss-of-function (LoF) variants. Seven patients (9.6%) carried damaging homozygous variants in five causal CHD genes. Six of those patients exhibited laterality defects (six HTX and one D-TGA). Three additional patients (4.1%) harbored other types of CHD-associated genomic …

Fibroblast Growth Factor-9 Expression In Airway Epithelial Cells Amplifies The Type I Interferon Response And Alters Influenza A Virus Pathogenesis, Bradley E. Hiller, Yongjun Yin, Yi-Chieh Perng, Ítalo De Araujo Castro, Lindsey E. Fox, Marissa C. Locke, Kristen J. Monte, Carolina B. López, David M. Ornitz, Deborah J. Lenschow

2020-Current year OA Pubs

Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors. Fibroblast growth factor-9 (FGF9) is required for lung development, can display antiviral activity in vitro, and is upregulated in asymptomatic patients during early IAV infection. We therefore hypothesized that FGF9 would protect the lungs from respiratory virus infection and evaluated IAV pathogenesis in mice that overexpress FGF9 in club cells in the conducting airway epithelium (FGF9-OE mice). However, we found that FGF9-OE mice were …

Network Assisted Analysis Of De Novo Variants Using Protein-Protein Interaction Information Identified 46 Candidate Genes For Congenital Heart Disease, Yuhan Xie, Wei Jiang, Weilai Dong, Hongyu Li, Sheng Chih Jin, Martina Brueckner, Hongyu Zhao

2020-Current year OA Pubs

De novo variants (DNVs) with deleterious effects have proved informative in identifying risk genes for early-onset diseases such as congenital heart disease (CHD). A number of statistical methods have been proposed for family-based studies or case/control studies to identify risk genes by screening genes with more DNVs than expected by chance in Whole Exome Sequencing (WES) studies. However, the statistical power is still limited for cohorts with thousands of subjects. Under the hypothesis that connected genes in protein-protein interaction (PPI) networks are more likely to share similar disease association status, we developed a Markov Random Field model that can leverage …

A Powassan Virus Domain Iii Nanoparticle Immunogen Elicits Neutralizing And Protective Antibodies In Mice, Ryan J. Malonis, George I. Georgiev, Denise Haslwanter, Laura A. Vanblargan, Georgia Fallon, Olivia Vergnolle, Sean M. Cahill, Richard Harris, David Cowburn, Kartik Chandran, Michael S Diamond, Jonathan R. Lai

2020-Current year OA Pubs

Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat POWV infection. Here, we generated and characterized a nanoparticle immunogen displaying domain III (EDIII) of the POWV E glycoprotein. Immunization with POWV EDIII presented on nanoparticles resulted in significantly higher serum neutralizing titers against POWV than immunization with monomeric POWV EDIII. Furthermore, passive transfer of EDIII-reactive sera protected against POWV challenge in vivo. We isolated and characterized a panel of EDIII-specific monoclonal antibodies (mAbs) and identified several that potently inhibit POWV infection and engage distinct …

Genetic, Epigenetic, And Environmental Mechanisms Govern Allele-Specific Gene Expression, Celine L St Pierre, Juan F Macias-Velasco, Jessica P Wayhart, Li Yin, Clay F Semenkovich, Heather A Lawson

2020-Current year OA Pubs

Allele-specific expression (ASE) is a phenomenon in which one allele is preferentially expressed over the other. Genetic and epigenetic factors cause ASE by altering the final composition of a gene's product, leading to expression imbalances that can have functional consequences on phenotypes. Environmental signals also impact allele-specific expression, but how they contribute to this cross talk remains understudied. Here, we explored how genotype, parent-of-origin, tissue, sex, and dietary fat simultaneously influence ASE biases. Male and female mice from a F

Radiopharmaceutical Quality Control Considerations For Accelerator-Produced Actinium Therapies, Diane S Abou, Patrick Zerkel, James Robben, Mark Mclaughlin, Tim Hazlehurst, David Morse, Thaddeus J Wadas, Darpan N Pandya, Reiko Oyama, Gregory Gaehle, Michael L Nickels, Daniel L J Thorek

2020-Current year OA Pubs

No abstract provided.

Determination Of The Electronic Portal Imaging Device Pixel-Sensitivity-Map For Quality Assurance Applications. Part 1: Comparison Of Methods, Michael Paul Barnes, Baozhou Sun, Brad Michael Oborn, Bishnu Lamichhane, Stuart Szwec, Matthew Schmidt, Bin Cai, Frederick Menk, Peter Greer

2020-Current year OA Pubs

PURPOSE: Calibration of a radiotherapy electronic portal imaging device (EPID) using the pixel-sensitivity-map (PSM) in place of the flood field correction improves the utility of the EPID for quality assurance applications. Multiple methods are available for determining the PSM and this study provides an evaluation to inform on which is superior.

METHODS: Three different empirical methods ("Calvary Mater Newcastle" [CMN], "Varian," and "WashU") and a Monte Carlo-based method of PSM determination were investigated on a single Varian TrueBeam STx linear accelerator (linac) with an aS1200 EPID panel. PSM measurements were performed for each empirical method three successive times using the …

Association Of State Medicaid Expansion Status With Rates Of Suicide Among Us Adults, Hetal Patel, Justin Barnes, Nosayaba Osazuwa-Peters, Laura Jean Bierut

2020-Current year OA Pubs

Importance: In the US, suicide is the 10th leading cause of death and a serious mental health emergency. National programs that address suicide list access to mental health care as key in prevention, and more large-scale policies are needed to improve access to mental health care and address this crisis. The Patient Protection and Affordable Care Act (ACA) Medicaid Expansion Program was implemented in several states with the goal of increasing access to the health care system.

Objective: To compare changes in suicide rates in states that expanded Medicaid under the ACA vs states that did not.

Design, Setting, and …

Analysis Of Electrophysiological Activation Of The Uterus During Human Labor Contractions, Alison G Cahill, Zichao Wen, Hui Wang, Peinan Zhao, Zhexian Sun, Alan L Schwartz, Yong Wang

2020-Current year OA Pubs

No abstract provided.

A Guide For Managing Patients With Stage I Nsclc: Deciding Between Lobectomy, Segmentectomy, Wedge, Sbrt And Ablation-Part 4: Systematic Review Of Evidence Involving Sbrt And Ablation, Henry S. Park, Frank C. Detterbeck, David C. Madoff, Brett C. Bade, Ulas Kumbasar, Vincent J. Mase, Andrew X. Li, Justin D. Blasberg, Gavitt A. Woodard, Whitney S. Brandt, Roy H. Decker

2020-Current year OA Pubs

Background: Clinical decision-making for patients with stage I lung cancer is complex. It involves multiple options [lobectomy, segmentectomy, wedge, stereotactic body radiotherapy (SBRT), thermal ablation], weighing multiple outcomes (e.g., short-, intermediate-, long-term) and multiple aspects of each (e.g., magnitude of a difference, the degree of confidence in the evidence, and the applicability to the patient and setting at hand). A structure is needed to summarize the relevant evidence for an individual patient and to identify which outcomes have the greatest impact on the decision-making.

Methods: A PubMed systematic review from 2000-2021 of outcomes after SBRT or thermal ablation

Results: Short-term …

A Guide For Managing Patients With Stage I Nsclc: Deciding Between Lobectomy, Segmentectomy, Wedge, Sbrt And Ablation-Part 2: Systematic Review Of Evidence Regarding Resection Extent In Generally Healthy Patients, Frank C. Detterbeck, Vincent J. Mase, Andrew X. Li, Ulas Kumbasar, Brett C. Bade, Henry S. Park, Roy H. Decker, David C. Madoff, Gavitt A. Woodard, Whitney S Brandt, Justin D. Blasberg

2020-Current year OA Pubs

Background: Clinical decision-making for patients with stage I lung cancer is complex. It involves multiple options (lobectomy, segmentectomy, wedge, stereotactic body radiotherapy, thermal ablation), weighing multiple outcomes (e.g., short-, intermediate-, long-term) and multiple aspects of each (e.g., magnitude of a difference, the degree of confidence in the evidence, and the applicability to the patient and setting at hand). A structure is needed to summarize the relevant evidence for an individual patient and to identify which outcomes have the greatest impact on the decision-making.

Methods: A PubMed systematic review from 2000-2021 of outcomes after lobectomy, segmentectomy and wedge resection in generally …

A Guide For Managing Patients With Stage I Nsclc: Deciding Between Lobectomy, Segmentectomy, Wedge, Sbrt And Ablation-Part 3: Systematic Review Of Evidence Regarding Surgery In Compromised Patients Or Specific Tumors, Brett C. Bade, Justin D. Blasberg, Vincent J. Mase, Ulas Kumbasar, Andrew X. Li, Henry S. Park, Roy H. Decker, David C. Madoff, Whitney S. Brandt, Gavitt A. Woodard, Frank C. Detterbeck

2020-Current year OA Pubs

Background: Clinical decision-making for patients with stage I lung cancer is complex. It involves multiple options [lobectomy, segmentectomy, wedge, stereotactic body radiotherapy (SBRT), thermal ablation], weighing multiple outcomes (e.g., short-, intermediate-, long-term) and multiple aspects of each (e.g., magnitude of a difference, the degree of confidence in the evidence, and the applicability to the patient and setting at hand). A structure is needed to summarize the relevant evidence for an individual patient and to identify which outcomes have the greatest impact on the decision-making.

Methods: A PubMed systematic review from 2000-2021 of outcomes after lobectomy, segmentectomy and wedge resection in …