Medicine and Health Sciences Commons^™

Influence Of Extracellular Volume Fraction On Peak Exercise Oxygen Pulse Following Thoracic Radiotherapy, Justin M. Canada, Elisabeth Weiss, John D. Grizzard, Cory R. Trankle, Leila Rezai Gharai, Franklin Dana, Leo F. Buckley, Salvatore Carbone, Dinesh Kadariya, Anthony Ricco, Jennifer H. Jordan, Ronald K. Evans, Ryan S. Garten, Benjamin W. Van Tassell, W. Gregory Hundley, Antonio Abbate

Internal Medicine Publications

Background

Radiation-induced myocardial fibrosis increases heart failure (HF) risk and is associated with a restrictive cardiomyopathy phenotype. The myocardial extracellular volume fraction (ECVF) using contrast-enhanced cardiac magnetic resonance (CMR) quantifies the extent of fibrosis which, in severe cases, results in a noncompliant left ventricle (LV) with an inability to augment exercise stroke volume (SV). The peak exercise oxygen pulse (O2Pulse), a noninvasive surrogate for exercise SV, may provide mechanistic insight into cardiac reserve. The relationship between LV ECVF and O2Pulse following thoracic radiotherapy has not been explored.

Methods

Patients who underwent thoracic radiotherapy for chest malignancies with significant incidental heart …

Free, Fair, And Fabulous: Five Data Tools To Support Open And Reproducible Research At Your Institution, Christine Nieman, Katie Pierce-Farrier, Sean Corning, Elizabeth Roth

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

With more publishers and funders requiring data management and sharing plans, it is important for librarians, researchers, and support staff to be aware of the tools available to help them skillfully manage research data. There are a wide variety of tools available, both free and paid, that can work with data but selecting an affordable, accessible tool can be a barrier to use.

Description

This poster seeks to promote awareness of freely available tools for data management, wrangling, and sharing for use in daily work and research projects. The poster will review five data tools (DMPTool, NIH Common Data …

Choose Environmental Health And Justice As Your Next Adventure, April Wright, Faith Steele, Tiffany Chavis, Christine Nieman

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

With health outcomes and disparities being linked to environmental degradation, libraries and librarians have an opportunity to empower their communities with information. Librarians, public health practitioners and community scientists can benefit from learning about environmental health and justice, specifically about how these topics can have an impact on heath literacy and rural health.

Description

Environmental conditions as a social determinant of health was identified by Healthy People 2030 as one of its priority areas. Our lightning talk will discuss the importance of understanding environmental health and justice issues related to medically underserved communities. Environmental justice issues are known to …

Resources For Osteopathic Medicine, Elaine Powers, Jessica Muller

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

Collection development for Colleges of Osteopathic Medicine (COMs) has been a challenge since strictly osteopathic resources are somewhat specialized in regard to content and acquisition.

Description

This poster will present a list of textbooks and journals needed to develop an osteopathic library collection. Organizations and publishers with osteopathic resources will also be described.

Conclusions

A “top ten” list of osteopathic titles as well as a comprehensive list of osteopathic books and resources provide collection development guidelines for Colleges of Osteopathic Medicine as well as for librarians in other types of medical facilities. Creation of a QR code will provide …

Healthcare Utilization And Costs Among High-Need And Frail Mexican American Medicare Beneficiaries, Maricruz Rivera-Hernandez, Amit Kumar, Lin-Na Chou, Tamra Keeney, Nasim Ferdows, Amol Karmarkar, Kyriakos S. Markides, Kenneth Ottenbacher

Physical Medicine and Rehabilitation Publications

Objectives
To examine Medicare health care spending and health services utilization among high-need population segments in older Mexican Americans, and to examine the association of frailty on health care spending and utilization.

Methods
Retrospective cohort study of the innovative linkage of Medicare data with the Hispanic Established Populations for the Epidemiologic Study of the Elderly (H-EPESE) were used. There were 863 participants, which contributed 1,629 person years of information. Frailty, cognition, and social risk factors were identified from the H-EPESE, and chronic conditions were identified from the Medicare file. The Cost and Use file was used to calculate four categories …

Perspectives On Primary Blast Injury Of The Brain: Translational Insights Into Non-Inertial Low-Intensity Blast Injury, Heather R. Siedhoff, Shanyan Chen, Hailong Song, Jiankun Cui, Ibolja Cernak, David X. Cifu, Ralph G. Depalma, Zezong Gu

Physical Medicine and Rehabilitation Publications

Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild” and frequently caused by non-impact blast exposures. Experimental models were developed to reproduce the biological consequences of high-intensity blasts causing moderate to severe brain injuries. However, the pathophysiological mechanisms of low-intensity blast (LIB)-induced neurological deficits have been understudied. This review provides perspectives on primary blast-induced mild TBI models and discusses translational aspects of LIB exposures as defined by standardized physical parameters including overpressure, impulse, and shock wave velocity. Our mouse LIB-exposure model, which reproduces deployment-related scenarios of open-field blast (OFB), caused neurobehavioral changes, including reduced exploratory activities, …

Age-Related Changes And Longitudinal Stability Of Individual Differences In Abcd Neurocognition Measures, Andrey P. Anokhin, Monica Luciana, Marie Banich, Deanna M. Barch, James M. Bjork, Marybel R. Gonzalez, Raul Gonzalez, Frank Haist, Joanna Jacobus, Krista Lisdahl, Erin Mcglade, Bruce Mccandliss, Bonnie Nagel, Sara J. Nixon, Susan Tapert, James T. Kennedy, Wesley K. Thompson

Psychiatry Publications

Temporal stability of individual differences is an important prerequisite for accurate tracking of prospective relationships between neurocognition and real-world behavioral outcomes such as substance abuse and psychopathology. Here we report age-related changes and longitudinal test-retest stability (TRS) for the Neurocognition battery of the Adolescent Brain and Cognitive Development (ABCD) study, which included the NIH Toolbox (TB) Cognitive Domain and additional memory and visuospatial processing tests administered at baseline (ages 9–11) and two-year follow-up. As expected, performance improved significantly with age, but the effect size varied broadly, with Pattern Comparison and the Crystallized Cognition Composite showing the largest age-related gain (Cohen’s …

Covid-19 Pandemic Impact On Us Childhood Caries And Potential Mitigation, Christina Scherrer, Shillpa Naavaal, Susan O. Griffin, Mei Lin

Dental Public Health and Policy Publications

Non-Hispanic Black (NHB) and Hispanic and low-income US children have a higher prevalence of untreated caries than their higher-income and non-Hispanic White (NHW) counterparts. Due to the COVID-19 pandemic, many dental offices and school sealant programs closed beginning March 2020. We examine the effect of reduced access to restorative care and sealants on the oral health of children from low-income households overall and by race/ethnicity and how increased sealant delivery in September 2022 could mitigate these effects. We used Markov chain Monte Carlo simulation to model COVID-19’s impact on first permanent molar (1M) caries incidence and loss in quality of …

Comprehensive Pregnancy Dental Benefits Improved Dental Coverage And Increased Dental Care Utilization Among Medicaid-Enrolled Pregnant Women In Virginia, Shillpa Naavaal, David W. Harless

Dental Public Health and Policy Publications

Objectives: To evaluate the changes in dental insurance and utilization among pregnant women before and after the pregnancy Medicaid dental benefit policy implementation in 2015 in Virginia.

Methods: We used pooled cross-sectional data from six cycles of the Virginia Pregnancy Risk Assessment Monitoring System on women aged ≥21 years. Using logistic regression models and a difference-in-difference design, we compared the effects of policy implementation on dental insurance and utilization between pre-policy (2013-2014) and post-policy period (2016-2019) among women enrolled in Medicaid (treatment, N = 1,105) vs. those with private insurance (control, N = 2,575). A p-value of 0.05 was …

Managing Hypertension, Diabetes, And Cardiovascular Disease Risk Via Short-Term Medical Trips: A Retrospective Longitudinal Study In Santo Domingo, Rose Baumann, Reuben P. Retnam, Carlos M. Hernandez, Victoria Edwards, Mark Ryan

Biostatistics Publications

Background: Short-term medical trips (STMTs) from high-resource countries frequently provide care in low and middle-income countries. Little existing literature objectively tracks the long-term outcomes of these interventions on the receiving populations over time to assess potential benefits and to ensure no harm is being done.

Objectives: The purpose of this study was to objectively analyze the outcomes of a biannual STMT to Santo Domingo, Dominican Republic on hypertension (HTN), diabetes mellitus type 2 (DM2), and cardiovascular disease (CVD) risk over a five-year period (2015-2019).

Methods: Data from 1655 patients was extracted from the electronic medical record. In …

Long-Read Sequencing Of The Zebrafish Genome Reorganizes Genomic Architecture, Yelena Chernyavskaya, Xiaofei Zhang, Jinze Liu, Jessica Blackburn

Biostatistics Publications

Background

Nanopore sequencing technology has revolutionized the field of genome biology with its ability to generate extra-long reads that can resolve regions of the genome that were previously inaccessible to short-read sequencing platforms. Over 50% of the zebrafish genome consists of difficult to map, highly repetitive, low complexity elements that pose inherent problems for short-read sequencers and assemblers.

Results

We used long-read nanopore sequencing to generate a de novo assembly of the zebrafish genome and compared our assembly to the current reference genome, GRCz11. The new assembly identified 1697 novel insertions and deletions over one kilobase in length and placed …

Social Cognitive Outcomes Are Associated With Improvements In Mobility Performance Following Lifestyle Intervention In Prostate Cancer Patients Undergoing Androgen Deprivation Therapy, Zachary L. Chaplow, Alexander R. Lucas, Elizabeth Grainger, Christina Simpson, Ciaran M. Fairman, Victoria R. Descenza, Jessica Bowman, Steven K. Clinton, Brian C. Focht

Health Policy Publications

Objective
To compare the effects of an exercise and dietary intervention with those of standard-of-care management upon change in lift and carry performance and mobility-related self-efficacy beliefs and explore associations in prostate cancer patients undergoing androgen deprivation therapy.

Methods
32 prostate cancer patients (M age = 66.2 years; SD = 7.8) undergoing androgen deprivation therapy were randomly assigned to a 3-month exercise and dietary lifestyle intervention (n = 16) or standard-of-care management (n = 16). Outcome assessments were obtained at baseline, 2- and 3-month follow-up.

Results
The lifestyle intervention resulted in significantly greater improvements in lift and …

Association Between Periodontal Disease And Oral Cancer Screening Among Us Adults: Nhanes 2011-2014, Shillpa Naavaal, Dina T. Garcia, Xiaoyan Deng, Dipankar Bandyopadhya

Dental Public Health and Policy Publications

Objectives:

To examine oral cancer screening rates and associated factors among adults with periodontal disease (PD). We hypothesized that adults with severe PD will be less likely to report receipt of any type of oral cancer screening than adults with no PD.

Materials and Methods:

We used 2011-2014 National Health and Nutrition Examination Survey (NHANES) data on adults ≥ 30 years. PD status was classified as no PD, mild/moderate PD, and severe PD. Survey-adjusted logistic regression analysis was used to examine the model adjusted risk ratio (RR) and 95% confidence intervals (CI) for the outcome of not receiving intraoral, extraoral …

Virginia Dental Journal (Vol. 99, No. 4, 2022)

Virginia Dental Journal

No abstract provided.

Dermatologic Manifestations Of Rheumatic Disease: Cutaneous Manifestations Of Sarcoidosis, Sarah Shapiro, Sindhuja Koppu, Mavra Masood, Beth Rubinstein, Huzaefah Syed

Open and Affordable Course Content at VCU

No abstract provided.

Sorafenib, Rapamycin, And Venetoclax Attenuate Doxorubicin-Induced Senescence And Promote Apoptosis In Hct116 Cells, Homood M. As Sobeai, Munirah Alohaydib, Ali R. Alhoshani, Khalid Alhazzani, Mashal M. Almutairi, Tareq Saleh, David A. Gewirtz, Moureq R. Alotiabi

Pharmacology and Toxicology Publications

Emerging evidence has shown that the therapy-induced senescent growth arrest in cancer cells is of durable nature whereby a subset of cells can reinstate proliferative capacity. Promising new drugs named senolytics selectively target senescent cells and commit them into apoptosis. Accordingly, senolytics have been proposed as adjuvant cancer treatment to cull senescent tumor cells, and thus, screening for agents that exhibit senolytic properties is highly warranted. Our study aimed to investigate three agents, sorafenib, rapamycin, and venetoclax for their senolytic potential in doxorubicin-induced senescence in HCT116 cells. HCT116 cells were treated with one of the three agents, sorafenib …

Protective Factors Against Alcohol Use In High-Risk College Students, Delani F. Warner, Karen G. Chartier Phd, Msw, The Spit For Science Working Group

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

The Role Of The Nlrp3 Inflammasome In Alzheimer's Disease, Ethan Terman

IRBEH/Spit for Science Publications and Presentations

This study examines the consequences of Alzheimer’s in rat and mice test subjects. The goal is to identify the effects of certain NLRP3 inhibiting drugs and to see if there are any noticeable effects in regards to impeding the pathological development of Alzheimer’s disease. The results are visualized by implementing the immunohistochemical process to identify neurodegeneration in the brain and to assess the expression levels of amyloid beta as an indicator of Alzheimer’s pathology. Other tests are also conducted on these transgenic mice to gauge cognitive functioning levels during the onset of their disease, those being behavior tests, but not …

Trends In Dental Workforce In Virginia, Reem Hashmi, Shillpa Naavaal Bds, Ms, Mph

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

An Analysis Of Mild Traumatic Brain Injury And Problematic Alcohol Consumption Amongst Post-9/11 Veterans, Anika Tosh, Christina Sheerin Phd

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

Have Conditions Improved? Disparities In Health Care Quality Among Asian Children With Special Health Care Needs, Kayla Van, Ruth Brown Phd, Esther Son Phd

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

T1 (Spring 2019) Ethnic-Racial Identity Affirmation Predicting T2 (Spring 2020) Romantic Partner/Friend Relationship Changes Predicting T3 (Fall 2021) Alcohol Use And Anxiety Symptoms Among Latinx Emerging Adults, Vanessa Olazabal, Mehak Ahmed, April Koontz, Arlenis Santana, Chelsea Williams Phd, The Spit For Science Working Group, Danielle Dick Phd

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

Viral Overexpression Of Rprd2 In Mouse Nucleus Accumbens Induces Anxiety-Like Behavior And Regulates Genes Associated With Microtubule Transport, Claire Nuhad Atiyeh

Theses and Dissertations

Anxiety disorders are the most prevalent mental illness in the United States with many individuals underdiagnosed and undertreated (Anxiety & Depression Association of America, 2021; Bandelow et al., 2017). While stress is a known risk factor for developing anxiety disorders, there is emerging evidence that biological variability in the expression of key proteins in the brain may contribute to regulating an organism’s stress-related behaviors. Earlier work from our laboratory identified a protein, called Regulation of Nuclear Pre-mRNA Domain Containing 2 (RPRD2), that was differentially expressed in the brain of mice stratified in terms of their phenotypic response to chronic stress …

Splanchnic Oxygenation And Feeding Intolerance In The Very Low Birthweight Infant, Melissa C. Dollings

Theses and Dissertations

SPLANCHNIC OXYGENATION AND FEEDING INTOLERANCE IN THE VERY LOW BIRTHWEIGHT INFANT

By Melissa C. Dollings, Ph.D.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University

Virginia Commonwealth University, 2022

Major Director: Lisa F. Brown, Ph.D., RN, School of Nursing

Background. Feeding intolerance is common in preterm infants but can be an ominous precursor of necrotizing enterocolitis, a life-threatening gastrointestinal disease. The definition and management of feeding intolerance vary widely. This research examined the relationship

between feeding intolerance, intrauterine factors, extrauterine factors, and intestinal immaturity and circulatory immaturity in the …

Outcome Of Endodontic Microsurgery: Success And Survival Rates At Virginia Commonwealth University, Abdullah Alawadhi

Theses and Dissertations

Introduction: Endodontic microsurgery treatment is an option for teeth with apical periodontitis and may be indicated for teeth with previous endodontic treatment that have not healed, teeth with canal obstructions which would impede a non-surgical approach, and where a biopsy is needed. The purpose of this study is to evaluate healing after endodontic microsurgery in 2-dimensional PA radiographs and 3 dimensional CBCT imaging. Methods: Patient records were pooled from graduate resident cases completed at Virginia Commonwealth University in the Graduate Endodontic Clinic between the years 2010 to 2020. Cases were identified using the CDT codes and a key word search …

Adaptations In Orthodontics For Current And Future Covid-19 Best Practices, Jordan Lamb

Theses and Dissertations

Purpose: To determine what adaptations orthodontists made in their practices during the COVID-19 pandemic in response to safety recommendations and to determine which of these adaptations orthodontists plan to continue to implement after resolution of the COVID-19 pandemic.

Methods: An original 34-question survey was sent by mail to a randomized and geographically proportionate selection of actively practicing orthodontic specialists (N = 1000). Questions asked orthodontists about the changes they made during the pandemic in four overarching categories (infection control, social distancing, appliance use, and tele-orthodontics) and whether they anticipated keeping those changes post-pandemic. The data were compared between categorical responses …

The Effect Of Er:Yag, Nd:Yag And Co2 Laser Combined With Hydrogen Peroxide, Sodium Hypochlorite, Chlorohexidine Or Fluoride On Reducing Oral Bacterial Count Implicated In Root Caries, Nitya Reddy

Theses and Dissertations

Purpose: Lasers have been used for treatment of dentinal hypersensitivity and for various bacterial reduction indications in periodontology. Their effectiveness in killing oral bacteria is not well known. The compounding effect of the combination of a laser treatment and adjunct antimicrobial agent use on bacterial viability is still evolving. The purpose of this in vitro study was to evaluate the effect of three lasers commonly used in dentistry in conjunction with chlorhexidine (CHX), hydrogen peroxide (H₂O₂), sodium hypochlorite (NaOCl), or sodium fluoride (NaF) on viability of oral bacteria associated with root caries.

Methods: Three …

Changes In Physical Activity And Relationships To Submaximal Exercise Capacity And Cardiac Function During Breast Cancer Therapy, Moriah P. Bellissimo

Theses and Dissertations

Background: Breast cancer (BC) survivors are at high risk for heart failure due to curative cancer therapies. In non-cancer populations, physical activity is a first line treatment for preventing cardiovascular disease. This study examined whether more physical activity was associated with better submaximal exercise capacity and cardiac function during the first three months of cancer therapy.

Methods: Participants included 223 women with stage I-III BC before therapy and after three months of undergoing treatment and 126 controls. Leisure time physical activity was reported using the Godin Sheppard leisure time exercise questionnaire. Cardiac function was assessed by cardiac magnetic resonance, and …

Characteristics Of Posterior Permanent Teeth With A Periradicular Diagnosis Of Symptomatic Apical Periodontitis: A Retrospective Study, Christina A. Martin

Theses and Dissertations

The diagnosis of apical periodontitis is based on radiographic manifestations and the results of the various clinical tests that can be performed as part of a routine dental examination. Apical periodontitis producing clinical symptoms involving a painful response to biting and/or percussion or palpation is given the diagnosis of symptomatic apical periodontitis (SAP). This study aimed to determine associations of SAP with gender, age, radiographic findings, diagnostic testing, pulpal diagnosis, and location of the tooth in the arch. Data for this study were obtained from patients of record treated at Virginia Commonwealth University School of Dentistry in the Department of …

Budget Impact Analysis Of Upadacitinib For The Management Of Moderate-To-Severe Atopic Dermatitis In Patients Treated With Systemic Therapies In The United States, Haya O. Alobaid

Theses and Dissertations

Objective: This study evaluated the budget impact of introducing upadacitinib for patients with uncontrolled moderate-to-severe atopic dermatitis (AD) from a United States (U.S.) private payer perspective.

Methods: The model estimated costs before and after the adoption of upadacitinib for a hypothetical one million covered lives over 3 years. The model included immunosuppressant agents and dupilumab. Market uptake was assumed to be 2% per year. Treatments incur a cost for drug acquisition, and the costs associated with drug administration, laboratory testing, and clinic visits. The model calculated the impact on the budget in 2022 U.S. dollars. Various assumptions on market …