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Full-Text Articles in Medicine and Health Sciences

Contents Jan 1965

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Summer 1965, Volume One, Number Two.

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The Need For Change In Medical Education, Fairfield Goodale Jr. Jan 1965

The Need For Change In Medical Education, Fairfield Goodale Jr.

MCV/Q, Medical College of Virginia Quarterly

The key to tomorrow's medical practice lies, not in the development of better clinical artisans, but in the development of clinicians who can interpret disease through application of the basic sciences. A medical curriculum at a graduate student level, based on patient-centered teaching with strong and continuous basic science correlation, could provide such clinician-scientists.

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An Approach To Medical Education: The Medical College Of Virginia School Of Medicine Curriculum, Edwin F. Rosinski Jan 1965

An Approach To Medical Education: The Medical College Of Virginia School Of Medicine Curriculum, Edwin F. Rosinski

MCV/Q, Medical College of Virginia Quarterly

After a relatively long interval in which the status quo was maintained, in the early 1950's American medical schools began to reappraise their educational programs. Many shortcomings of medical education which now have been corrected were cited as early as 1946. The Medical College of Virginia began a detailed study of its educational program. A curriculum has been designed and initiated, using the subject matter committee approach. The curriculum provides opportunity for electives, research, and free time. In conjunction with the revised curriculum, changes in grading procedures, examinations, and teaching methods have been made. A study to assess the effects …

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Physiological Basis Of The Radioisotope Renogram, Louis D. Homer, Hermes A. Kontos, Joseph Magee, Malcolm E. Turner, James Oates Iii, Alton Sharpe Jr. Jan 1965

Physiological Basis Of The Radioisotope Renogram, Louis D. Homer, Hermes A. Kontos, Joseph Magee, Malcolm E. Turner, James Oates Iii, Alton Sharpe Jr.

MCV/Q, Medical College of Virginia Quarterly

A model elucidating the relationships between blood radioactivity, the renogram curve, and urine radioactivity, as a function of time, is derived. Estimation procedures have been devised which use the data from three curves at once to estimate parameters common to the three curves, and which also estimate parameters unique to the individual curves. A program has been written for the RPC 4000 computer to perform the estimation. It was found that some model in which six different exponential parameters could be justified instead of the two proposed by the model could provide a significantly better fit of the data (P < .001), but that the fit under the hypothesis was still quite good.

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Treatment Of Hypertension, Edward D. Freis Jan 1965

Treatment Of Hypertension, Edward D. Freis

MCV/Q, Medical College of Virginia Quarterly

Our ideas about the management of hypertension have changed considerably in recent years. There is now general agreement that all patients with accelerated hypertension, as manifested by high diastolic pressure and Group III and IV funduscopic changes, should have their blood pressure reduced with antihypertensive agents. Differences of opinion still exist, however, in respect to the treatment of the less rapidly advancing types of hypertension. It is apparent that the life history of untreated essential hypertension varies widely from those patients whose lives are cut short in a matter of a few years, to those who survive to old age. …

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Clinical Hemodynamics And Pharmacodynamics Of Toxemia, Frank A. Finnerty Jr. Jan 1965

Clinical Hemodynamics And Pharmacodynamics Of Toxemia, Frank A. Finnerty Jr.

MCV/Q, Medical College of Virginia Quarterly

For many years toxemia has served as a wastebasket for a variety of disease states characterized by an elevated arterial pressure, edema, and albuminuria. Whereas this triad is consistent with the diagnosis of toxemia, it is not diagnostic. Besides toxemia, these abnormalities may be found in pregnant patients with hypertensive vascular disease, pyelonephritis, glomerulonephritis, or any combination of these. Data derived from studies performed on patients with such a variety of disease entities have obviously been confusing. It makes a lot of difference, for example, whether the subjects studied had chronic pyelonephritis or acute vasospastic toxemia. During the past 13 …

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Panel On Arteriosclerosis, William Dock Jan 1965

Panel On Arteriosclerosis, William Dock

MCV/Q, Medical College of Virginia Quarterly

Panel on Arteriosclerosis held during the Thirty-Sixth annual McGuire Symposium on Hypertension and Arteriosclerosis, Medical College of Virginia, October 7-9, 1964, moderated by William Dock.

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Calender [I.E. Calendar] Of Postgraduate Education Jan 1965

Calender [I.E. Calendar] Of Postgraduate Education

MCV/Q, Medical College of Virginia Quarterly

Calendar of postgraduate education for the Medical College of Virginia, Fall 1965.

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Mcv/Q, Medical College Of Virginia Quarterly, Vol. 1 No. 3 Jan 1965

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 1 No. 3

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

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The Treatment Of Chronic Uremia, Belding H. Scribner Jan 1965

The Treatment Of Chronic Uremia, Belding H. Scribner

MCV/Q, Medical College of Virginia Quarterly

I will begin by telling a little about the development of chronic dialysis. In 1959 we were working on a system to prevent uremia in acute renal failure. We were trying to develop a system to which we could "hook" the patient for as long as a week, so that we would exactly mimic his normal kidney function during the period of acute renal failure, and make his prognosis that of a patient who had kidneys. The system worked reasonably well. We had to make a lot of modifications, such as using a Skeggs-Leonard dialyzer with low resistance. We used …

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The Frequency And Natural History Of Urinary Tract Infection In School Children, Calvin M. Kunin Jan 1965

The Frequency And Natural History Of Urinary Tract Infection In School Children, Calvin M. Kunin

MCV/Q, Medical College of Virginia Quarterly

This presentation reviews briefly investigations of the epidemiology and natural history of urinary tract infections in school children conducted during the past four years in Central Virginia. The results of this work will be summarized and their implications discussed.

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Oxygen Affinities And Electrophoretic Patterns Of Hemoglobins In Trout And Basses From Virginia, Jack D. Burke Jan 1965

Oxygen Affinities And Electrophoretic Patterns Of Hemoglobins In Trout And Basses From Virginia, Jack D. Burke

MCV/Q, Medical College of Virginia Quarterly

Hemoglobin solutions were prepared from pooled samples of blood taken from each of the following species; Salmo gairdneri, the rainbow trout; Salvelinus fontinalis, the brook trout; Salmo trutta, the brown trout; Micropterus dolomieui, the smallmouth bass; Micropterus salmoides, the largemouth bass. Hemoglobin electrophoretic patterns for each species were developed on cellulose acetate membranes. Oxyhemoglobin affinity curves were determined spectrophotometrically on different hemoglobin solutions from each species. Interspecific differences concerned with hemoglobin electrophoretic patterns, oxyhemoglobin affinities, and the Bohr effect were shown for both trout and basses.

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Gastric Secretion Mediated By Extravagal Neural Influences, Charles H. Hockman, Ebbe C. Hoff Jan 1965

Gastric Secretion Mediated By Extravagal Neural Influences, Charles H. Hockman, Ebbe C. Hoff

MCV/Q, Medical College of Virginia Quarterly

In adult cats anesthetized with ether and immobilized with Flaxedil, the effects of electrical stimulation of cerebral loci on gastric secretion were studied. Stimulation of mesencephalic and diencephalic areas increased both the volume and acidity of samples collected hourly. Section of the spinal cord at the level of the second cervical vertebra abolished this secretion; however, subsequent stimulation in the lateral funiculus of the distal end of the severed cord elicited the response. These pilot studies present further evidence for extravagal mediation of gastric secretion.

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Radiologic Diagnosis Of Congenital Heart Disease In Children, Richard G. Lester Jan 1965

Radiologic Diagnosis Of Congenital Heart Disease In Children, Richard G. Lester

MCV/Q, Medical College of Virginia Quarterly

The importance of precise anatomic and physiologic diagnosis in congenital heart disease has been emphasized in recent years, because of the increasing possibilities of surgical correction. The x-ray examination is a powerful tool in the evaluation of patients with congenital heart disease. A method of evaluation is presented, using conventional roentgenographic and fluoroscopic examination along with other simple clinical methods. This approach is relatively simple, can be carried out as an office procedure, and yields a firm clinical diagnosis in the majority of cases. Cardiac catheterization and selective angiocardiography may be necessary to give precise information on physiological abnormalities and …

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Contributors To This Issue Jan 1965

Contributors To This Issue

MCV/Q, Medical College of Virginia Quarterly

List of contributors to this issue includes Alvan R. Feinstein, Frank A. Finnerty, Jr., Edward David Freis, Walter J. Geeraets, Alice C. Goodman, Louis Homer, A. John Honour, Hermes A. Kontos, Richard G. Lester, Joseph H. Magee, James Franklin Oates, III, Sir George White Pickering, David W. Richardson, Edwin F. Rosinski, Ralph M. Scott, Malcolm E. Turner, and Alton R. Sharpe, Jr.

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The Effect Of Idoxuridine (Idu) On Corneal Stromal Cells In Tissue Culture, Walter J. Geeraets, Guy Wong, Dupont Guerry Iii Jan 1965

The Effect Of Idoxuridine (Idu) On Corneal Stromal Cells In Tissue Culture, Walter J. Geeraets, Guy Wong, Dupont Guerry Iii

MCV/Q, Medical College of Virginia Quarterly

Corneal stromal cells were cultured in vitro and exposed to various concentrations of idoxuridine (IDU), ranging from 0 to 1,000 μg of IDU per ml of medium. Inhibition of cell multiplication occurred with concentrations of 0.1 μg per ml. With concentrations of 1.0 μg per ml and greater, there was no increase in cell number from the time of exposure to IDU.

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Central Nervous Control Of Blood Pressure In Man; Preliminary Report, David W. Richardson, A. J. Honour, A. C. Goodman Jan 1965

Central Nervous Control Of Blood Pressure In Man; Preliminary Report, David W. Richardson, A. J. Honour, A. C. Goodman

MCV/Q, Medical College of Virginia Quarterly

Electrical activity of the brain, eye movements, arterial pressure, heart rate, and respiratory rate and depth have been recorded continuously during a night of sleep not induced by drugs in 22 healthy subjects, two hypertensive patients, and one anephric man who was awaiting renal transplantation. Sleep was associated with reduction in arterial pressure averaging 50 mm Hg systolic and 30 mm Hg diastolic. Dreams, although occasionally associated with marked elevation of blood pressure, were usually accompanied by no change or a slight fall in pressure. The dramatic paroxysmal electroencephalographic alterations termed K complexes, occurring spontaneously or after a noise in …

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Γ-Guanidinobutyric Acid: An Inhibitor Of Clot Formation And Of Clot Lysis, Phyllis S. Roberts Jan 1965

Γ-Guanidinobutyric Acid: An Inhibitor Of Clot Formation And Of Clot Lysis, Phyllis S. Roberts

MCV/Q, Medical College of Virginia Quarterly

During a study of the effects of a series of guanidine compounds on the esterolytic activities of thrombin, plasmin, and streptokinase plus plasmin or plasminogen, it was found that one of these compunds, γ-guanidinobutyric acid (GGBA), acted in several ways like ε-aminocaproic acid (EACA). Neither compound had any inhibiting effects on the rate of hydrolysis of TAMe (p-toluenesulfonyl-L-arginine methyl ester), but both inhibited the activation of plasminogen by streptokinase. EACA was the more potent inhibitor. Since EACA has been shown to inhibit the lysis of fibrin, primarily because it inhibits the activation of plasminogen (Ablondi et al., 1959, Alkjaersig, Fletcher, …

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Calendar Of Postgraduate Education Jan 1965

Calendar Of Postgraduate Education

MCV/Q, Medical College of Virginia Quarterly

Calendar of postgraduate education for the Medical College of Virginia, Spring 1965.

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Books Jan 1965

Books

MCV/Q, Medical College of Virginia Quarterly

Reviews of the following books: Curiosities of Medicine, An Assembly of Medical Diversions, 1552-1962, Berton Roueché, ed.; Body Fluids and the Acid-Base Balance, Halvor N. Christensen; and Respiratory Function in Disease, An Introduction to the Integrated Study of the Lung, David V. Bates and Ronald V. Christie.

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Mcv/Q, Medical College Of Virginia Quarterly, Vol. 1 No. 2 Jan 1965

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 1 No. 2

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

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Γ-Globulin Administration And Anti-Globulin Antibodies In Children, Marion Waller, Nellie Curry Jan 1965

Γ-Globulin Administration And Anti-Globulin Antibodies In Children, Marion Waller, Nellie Curry

MCV/Q, Medical College of Virginia Quarterly

We examined sera from 185 non-hospitalized children, 44 of whom had received repeated injections of γ-globulin for upper respiratory infections. There was no significant difference in the incidence of anti-globulin antibodies in the two groups. The presence of anti-globulin antibodies could not be correlated with the level of γ-globulin in the children's sera or with the age of the children.

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What Is A Modern Physician?, George W. Pickering Jan 1965

What Is A Modern Physician?, George W. Pickering

MCV/Q, Medical College of Virginia Quarterly

The first thing to remember is that the patient is not just a pair of tonsils, or perhaps, a skin, a prostate gland, or a pregnant uterus. This is a person. And it is essential that you should treat the patient as a person, as an individual who has feelings just like you and I have, who has a family background like you and I have, who has personal, domestic, and business problems, as most of us have.

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The Modern Treatment Of Respiratory Failure, David V. Bates Jan 1965

The Modern Treatment Of Respiratory Failure, David V. Bates

MCV/Q, Medical College of Virginia Quarterly

I suppose it is appropriate that we come to respiratory failure at the end of a longish day. The definition of respiratory failure has an interesting history. Barcroft, 30 to 40 years ago, understood respiratory failure as a tissue phenomenon. He would have described cyanide poisoning to you as an example of respiratory failure. "Ventilatory failure" came into fashion but is not a very good term because total ventilation may be fine but gas exchange may be very poor. Europeans have invented various terms like "global insufficiency," which sounds very impressive in German, but always sounds to me more like …

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Radiotherapy In The Management Of Oral Cancer, Ralph M. Scott Jan 1965

Radiotherapy In The Management Of Oral Cancer, Ralph M. Scott

MCV/Q, Medical College of Virginia Quarterly

Radiotherapy and surgery, used singly or in combination, are the only curative approaches to the treatment of mouth cancer. Preoperative irradiation of advanced cancer is now being evaluated, and shows much promise. This may permit operation in previously inoperable cases, make less extensive operative procedures feasible in others, and possibly decrease the incidence of cancer spread during surgery. However, while surgery often can salvage radiation failures, the reverse is seldom true.

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The Challenge Of Pulmonary Emphysema, David V. Bates Jan 1965

The Challenge Of Pulmonary Emphysema, David V. Bates

MCV/Q, Medical College of Virginia Quarterly

I feel very privileged to be invited to be your Stoneburner Lecturer for this year. When I came to consider what I really wanted to say and what might interest people in widely different areas of medicine, there really was little choice. I perhaps can claim to be able to talk about emphysema from a rather broad standpoint than some other physicians. Not because I suffer from it, which is sometimes a good reason for talking about a disease, but because I have been trained both in England and in America, and the outlook on this disease has differed in …

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Ethics In New Medicine: Tissue Transplants, Francis D. Moore Jan 1965

Ethics In New Medicine: Tissue Transplants, Francis D. Moore

MCV/Q, Medical College of Virginia Quarterly

Tissue transplantation, like other advances of the past, will react to the welfare of mankind if explored and exploited within the ethical bounds of science itself. Honesty and self-discipline must be held as values of the same importance as the very essence of all medical ethics: the welfare of the patient.

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The Effect Of Γ-Guanidinobutyric Acid On The Clotting Time Of Normal Plasma And On The Euglobulin Lysis Time Of Fibrinolytically Active Plasma, Lyman M. Fisher, Phyllis S. Roberts, Warner E. Braxton Jan 1965

The Effect Of Γ-Guanidinobutyric Acid On The Clotting Time Of Normal Plasma And On The Euglobulin Lysis Time Of Fibrinolytically Active Plasma, Lyman M. Fisher, Phyllis S. Roberts, Warner E. Braxton

MCV/Q, Medical College of Virginia Quarterly

It has been established that ε-aminocaproic acid (EACA) inhibits the activation of human plasminogen (Ablondi et al., 1959; Alkjaersig, Fletcher, and Sherry, 1959). Because of this observation, this compound has been used extensively to inhibit the pathologically occurring fibrinolytic system in patients. Recently Roberts (1965) reported that another compound, γ-guanidinobutyric acid (GGBA), like EACA, inhibits the lysis of human blood clots. Furthermore, GGBA, unlike EACA, retards the formation of these clots. The present investigation was undertaken to determine whether GGBA inhibits clot formation in the one-stage prothrombin and in the partial thromboplastin time tests. In addition, the ability of GGBA …

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Relative Incidence Of Pulmonary Emphysema Among Negroes And Whites Of Both Sexes, Edward S. Ray Jan 1965

Relative Incidence Of Pulmonary Emphysema Among Negroes And Whites Of Both Sexes, Edward S. Ray

MCV/Q, Medical College of Virginia Quarterly

There is an apparent correlation between cigarette smoking and the incidence of pulmonary emphysema. An increased incidence of emphysema is associated with increased cigarette consumption. The disease is relatively infrequent in those who have smoked less than a pack of cigarettes daily for less than 20 years. The low incidence of emphysema among females today may be explained by their low cigarette consumption. If this is true, this incidence should increase within the next decade because of cigarette consumption among today's younger females. The incidence of emphysema is lower among Negro males than would be expected from their smoking habits …

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Contributors To This Issue Jan 1965

Contributors To This Issue

MCV/Q, Medical College of Virginia Quarterly

List of contributors to this issue includes Phyllis Silver Roberts, Lyman McArthur Fisher, Warner E. Braxton, Fairfield Goodale, Jr., Elizabeth A. Hillman, Ralston Fillmore, Jack Denning Burke, Malcolm E. Turner, Charles H. Hockman, Ebbe Curtis Hoff, Walter J. Geeraets, Guy Wong, Du Pont Guerry, III, David V. Bates, Norman C. Staub, William Taliaferro Thompson, Jr., Edward S. Ray, and Sami I. Said.

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