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Full-Text Articles in Medicine and Health Sciences

Synthesis And Evaluation Of Some Arylalkenyl And Arylepoxyalkyl Hydrogen Succinates And Hydrogen Glutarates As Inhibitors Of Rat Liver Β-Hydroxy-Β-Methylglutaryl Coenzyme A Reductase, Paul Emil Marecki Jan 1974

Synthesis And Evaluation Of Some Arylalkenyl And Arylepoxyalkyl Hydrogen Succinates And Hydrogen Glutarates As Inhibitors Of Rat Liver Β-Hydroxy-Β-Methylglutaryl Coenzyme A Reductase, Paul Emil Marecki

Theses and Dissertations

Atherosclerotic disease is an almost universal phenomenon and increases in severity and frequency with increasing age. Atherosclerosis may contribute to several disorders including bursting of an artery, blockage of an artery, or induction of arterial clotting. The culmination of these diseases is usually premature since at the time of death the unaffected organs are in reasonably satisfactory condition and could have operated for several more years. Among the many factors which act in concert to produce the disease, serum cholesterol levels play a central role. It has been suggested that the lowering of cholesterol levels will provide an effective means …


Contents Jan 1973

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1973, Volume Nine, Number One.


Introduction, Charles L. Baird Jr. Jan 1973

Introduction, Charles L. Baird Jr.

MCV/Q, Medical College of Virginia Quarterly

This issue of the Medical College of Virginia Quarterly is devoted to the publication of the proceedings of the Cardiac Arrhythmias Symposium held at the Cavalier Hotel in Virginia Beach, Virginia from June 8-10, 1972. The reason for such emphasis upon the field of cardiac arrhythmias is primarily due to the fact that there has been an awakened interest in recent years in the problem of sudden death. It is now being appreciated that a significant number of deaths attributed to cardiovascular disease are due to cardiac arrhythmias, a potentially correctable disorder.


Electrophysiology Of Concealed Conduction, E. Neil Moore Jan 1973

Electrophysiology Of Concealed Conduction, E. Neil Moore

MCV/Q, Medical College of Virginia Quarterly

Several figures are presented here to demonstrate the different mechanisms of concealed conduction in which microelectrodes were used to record from the A-V node and His-Purkinje system together with simultaneously recorded atrial and ventricular electrograms. Of course, in a standard ECG, one would not be able to determine what was occurring within the specialized A-V conduction system, since only the information provided by the atrial and ventricular electrograms (P wave and QRS complex) would be available for interpretation.


Clinical Significance Of Exit Block, Irany M. De Azevedo, Yoshio Watanabe, Leonard S. Dreifus Jan 1973

Clinical Significance Of Exit Block, Irany M. De Azevedo, Yoshio Watanabe, Leonard S. Dreifus

MCV/Q, Medical College of Virginia Quarterly

Clinical features of exit block were shown and its probable electrophysiological mechanisms discussed. Based on recent electrophysiological studies, it is emphasized that exit block is a result of depressed conduction surrounding the ectopic pacemaker.


Workshop Presided By William A. Dickinson, Jr., William A. Dickinson Jr. Jan 1973

Workshop Presided By William A. Dickinson, Jr., William A. Dickinson Jr.

MCV/Q, Medical College of Virginia Quarterly

Workshop presided by William A. Dickinson, Jr. Transcript of three cases that were discussed.


Arterial Blood Gases: Their Meaning And Interpretation, Walter J. O'Donohue Jr. Jan 1973

Arterial Blood Gases: Their Meaning And Interpretation, Walter J. O'Donohue Jr.

MCV/Q, Medical College of Virginia Quarterly

The measurement of arterial blood gases is essential in the management of respiratory failure and in the diagnostic assessment of the nature and severity of pulmonary disease. Adequate therapy for patients with acute respiratory insufficiency is often impossible without the information obtained from arterial blood gases. These studies must be readily available around the clock, including nights, weekends, and holidays and should not have to depend upon a technician called in from home.


Complications Of Mechanical Ventilation, Orhan Muren Jan 1973

Complications Of Mechanical Ventilation, Orhan Muren

MCV/Q, Medical College of Virginia Quarterly

With increasing utilization of mechanical ventilation during the past decade or so, complications related to its use have also increased. Ventilators are primarily indicated when acceptable safe levels of oxygenation and ventilation cannot be maintained by other means.


Management Of Severe Asthma, William B. Hunt Jr. Jan 1973

Management Of Severe Asthma, William B. Hunt Jr.

MCV/Q, Medical College of Virginia Quarterly

In this summary of therapy for severe asthma there is no mention of etiologic factors. The author presumes that if infection is the primary factor in the progression to severe asthma that this will be recognized and appropriately treated. A chest x-ray must be an initial laboratory study for the recognition of pneumonia or complicating pneumothorax. However, unlike respiratory failure due to emphysema, here the specific therapy of the altered pulmonary physiology is of paramount importance.


Trauma Resulting In Respiratory Failure, James W. Brooks Jan 1973

Trauma Resulting In Respiratory Failure, James W. Brooks

MCV/Q, Medical College of Virginia Quarterly

Respiratory failure may occur secondary to thoracic trauma. Several important conditions develop as a result of chest injuries and may occur singly, or in combination, in patients with injuries from any cause. Unrecognized and therefore without proper management, the results are necessarily poor. If recognized and their mode of production is understood, treatment may be simple.


Contents Jan 1973

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1973, Volume Nine, Number Three.


A Twenty-Year Experience With Surgery For Ureteral Reflux, John Hutch Jan 1973

A Twenty-Year Experience With Surgery For Ureteral Reflux, John Hutch

MCV/Q, Medical College of Virginia Quarterly

This is a transcription of a lecture presented by Dr. John Hutch at the First Annual R. Carl Bunts Lecture in Urology, May 25, 1972.


Psychiatric Problems In Urology, James L. Mathis Jan 1973

Psychiatric Problems In Urology, James L. Mathis

MCV/Q, Medical College of Virginia Quarterly

In summary, the urologist cannot escape from a major responsibility for his patients' emotional components. The very area of his work is highly charged with emotional potential, primarily of a sexual nature. A careful sexual history is essential to the full understanding of the symptoms of many urological complaints and is equally necessary for the prevention of emotional complications to genital surgery.


The Urologist And The Law, Jack B. Russell Jan 1973

The Urologist And The Law, Jack B. Russell

MCV/Q, Medical College of Virginia Quarterly

Some of the matters I have referred to may seem unusual or unlikely and thus may not be long remembered. Let me reiterate, however, the importance of two items in particular. If nothing else remains long in your minds, do not forget that complete and adequate records are essential, both in the hospital and in the office. Nothing else will take their place when they are needed. Finally, keep in mind always the significance of informed consent. It is a rapidly changing principle and one which touches literally every field of medicine. It may be difficult to accept in all …


Urological Care Of The Paralyzed Patient, Robert H. Hackler Jan 1973

Urological Care Of The Paralyzed Patient, Robert H. Hackler

MCV/Q, Medical College of Virginia Quarterly

The paraplegic injured during World War I had only a 10% chance of surviving the first year. Only 20% of the American paraplegics could even be evacuated. A great majority of the deaths were caused by urinary tract sepsis. Starting in the mid and late 1940's, however, with the discovery of broad spectrum antibiotics, many of the early complications were eliminated and the survival rate greatly improved. Since 1946, over 2,000 patients have been admitted to the McGuire Veterans Administration Hospital. This spinal cord injury service receives approximately 400-500 admissions per year with about 70 being new patients.


Pediatric Uro-Radiology, Herman Grossman Jan 1973

Pediatric Uro-Radiology, Herman Grossman

MCV/Q, Medical College of Virginia Quarterly

"Routine" radiologic studies do not, often enough, concentrate on the part of the anatomy and physiology of importance for the diagnosis. The close cooperation between the pediatrician, urologist and the radiologist will insure more useful uro-radiographic studies on which rational clinical decisions can be based. The child's signs and symptoms, as well as the anatomic and physiologic information needed, dictate the type and order of the radiographic studies. It is beyond the scope of this paper to go into the indications for specific uro-radiographic studies. The radiographic techniques will be presented.


Advancing Technology Of Clinical Laboratory Practice, George Z. Williams Jan 1973

Advancing Technology Of Clinical Laboratory Practice, George Z. Williams

MCV/Q, Medical College of Virginia Quarterly

In spite of the temporary antitechnology attitude of a portion of our society, the future will be an era of automated technology. Buckminster Fuller has reviewed the progress of industrial technology and points out that continuing scientific advances are inevitable and that technical applications will provide more equitable distribution of wealth, more time, more opportunity for education and intellectual pursuits.


The Modernization Of The Autopsy: Application Of Ultrastructural And Biochemical Methods To Human Disease, Benjamin F. Trump, Jon M. Valigorsky, Jane H. Dees, Wolfgang J. Mergner, Kook M. Kim, Raymond T. Jones, Robert E. Pendergrass, Joel Garbus, Julio H. Garcia, Jesus E. Viloria, Junichi Tanaka, Hannu Kalimo, Yoshinari Kamijyo, R. Adams Cowley Jan 1973

The Modernization Of The Autopsy: Application Of Ultrastructural And Biochemical Methods To Human Disease, Benjamin F. Trump, Jon M. Valigorsky, Jane H. Dees, Wolfgang J. Mergner, Kook M. Kim, Raymond T. Jones, Robert E. Pendergrass, Joel Garbus, Julio H. Garcia, Jesus E. Viloria, Junichi Tanaka, Hannu Kalimo, Yoshinari Kamijyo, R. Adams Cowley

MCV/Q, Medical College of Virginia Quarterly

The autopsy has provided, and still provides, the stimulus for many attempts to reproduce disease in experimental animal models. This approach has become increasingly difficult, however, in the case of human disease, principally shock. The study of some pathological states in animal models requires testing in several species and final confirmation in man before this knowledge can be applied to living patients. In our studies the application of cell biology techniques at autopsy has permitted the generation of new hypotheses which are more amenable to further exploration in experimental models and can be more precisely related to human disease.


The Value Of Chemical Screening Profiles On Blood, Seymour Bakerman Jan 1973

The Value Of Chemical Screening Profiles On Blood, Seymour Bakerman

MCV/Q, Medical College of Virginia Quarterly

Chemical screening profiles on blood specimens are designed to yield information that may lead to new and additional clinical diagnoses, to revision of clinically established diagnoses, to confirmed impressions of the physician and to following the course of diseases during a patient's hospitalization. Screening profiles on blood are designed to indicate disease of the liver, kidney, heart, striated muscle and other organs; they may be helpful in the diagnosis of anemia, diabetes mellitus, gout, congestive heart failure, osteomalacia, and hyperlipidemia, hyperparathyroidism and other diseases. When these screening profiles were first introduced, there was widespread skepticism among physicians as to their …


Multitest Screening In Hematology, Charles L. Johnston Jr. Jan 1973

Multitest Screening In Hematology, Charles L. Johnston Jr.

MCV/Q, Medical College of Virginia Quarterly

The concept of multitest screening for hematological disorders is not necessarily a new one. Implementation of such ideas has recently become possible, for the automated electronic instruments performing sequential multiple analyses within very short periods of time are a very significant advancement in the technology of the hematology laboratory. It must be emphasized, however, that the value of such instrumentation lies not only in the rapidity, but also in the accuracy and precision as well as the number and nature of the tests performed. While the data on samples have been reported on individual patients three and a half years …


The Gouaux-Ashman Phenomenon: His Bundle Recordings, Benjamin J. Scherlag Jan 1973

The Gouaux-Ashman Phenomenon: His Bundle Recordings, Benjamin J. Scherlag

MCV/Q, Medical College of Virginia Quarterly

In conclusion, it is important to state the use of His bundle-electrocardiography in differentiating supraventricular beats with aberration from ventricular beats requires a critical approach to the interpretations of deflections appearing in the P-R segment. The use of quantitative rather than qualitative tests is essential when only the His bundle recording is used as opposed to the simultaneously recorded activity from the proximal bundle branches. In some cases, His bundle pacing may be helpful in reproducing spontaneously occurring aberrant patterns.


Utilization Of Blood And Its Products, Robert D. Langdell Jan 1973

Utilization Of Blood And Its Products, Robert D. Langdell

MCV/Q, Medical College of Virginia Quarterly

At present time there are a number of blood components that are more suitable for transfusion purposes than is whole blood. In order to make maximum use of blood, it is necessary that there be close cooperation between the blood bank personnel and those responsible for patient care.


Laboratory Aspects Of Venereal Disease, Mario R. Escobar Jan 1973

Laboratory Aspects Of Venereal Disease, Mario R. Escobar

MCV/Q, Medical College of Virginia Quarterly

Introducing the laboratory aspects of venereal diseases, I would like to define the criteria according to which certain infectious diseases are considered to be "sexually transmitted." The expression "sexually transmitted disorder" is less weighted with moral overtones than the term "venereal" and may therefore be more acceptable to both medical practitioners and the general public.


Unique Characteristics And Implications Of Individual Health Profiles, George Z. Williams Jan 1973

Unique Characteristics And Implications Of Individual Health Profiles, George Z. Williams

MCV/Q, Medical College of Virginia Quarterly

During the era of the prescientific medicine, people were divided into two categories: those who were sick and those who were not sick. Physicians found it necessary to establish criteria to differentiate the ill and separate them according to symptoms and signs characteristic of classifiable diseases. Because of preoccupation with disease, the concept of the "normal" versus the pathological, as two opposite and definable conditions, was inevitable in the absence of scientific knowledge of human chemistry and physiology. This concept has carried over into the present era of scientific medicine.


Pitfalls In Unqualified Acceptance Of Laboratory Data, Myrton F. Beeler Jan 1973

Pitfalls In Unqualified Acceptance Of Laboratory Data, Myrton F. Beeler

MCV/Q, Medical College of Virginia Quarterly

One can never be absolutely certain that any single laboratory report is correct. As a general rule, therefore, do not undertake potentially serious action on behalf of any patient solely because of a single laboratory report. This is especially important if the result is unexpected or not in harmony with the rest of the clinical information available.


Haa (Hb Ag) Evaluation-State Of The Art, Ali A. Hossaini, Mario R. Escobar Jan 1973

Haa (Hb Ag) Evaluation-State Of The Art, Ali A. Hossaini, Mario R. Escobar

MCV/Q, Medical College of Virginia Quarterly

In conclusion, this study supports the claim that the RIA is the most sensitive of all assay methods for detection of HB Ag in use today. Because of the inability to verify the presence of HB Ag in those sera positive by RIA alone, however, this claim must be taken only at face value. Further studies are needed to confirm the specificity of these positive reactions.


Microbial Monitoring, Harry P. Dalton Jan 1973

Microbial Monitoring, Harry P. Dalton

MCV/Q, Medical College of Virginia Quarterly

The need for monitoring both areas for alteration in microbial flora, which may result in invasion or adverse effect on internal organs of the host, has been an accepted scientific fact of modern medicine for years. Questions remain, however, on how much monitoring needs to be done. What areas of the patients and the environment should be tested, and what are the practical uses of the results of such monitoring? Before attempting to answer these questions, let me give you an overview of how microbial monitoring has been used at the Medical College of Virginia hospitals and other institutions to …


The Pharmacology And Clinical Use Of Lidocaine And Procainamide, J. Thomas Bigger Jr., Elsa-Grace V. Giardina Jan 1973

The Pharmacology And Clinical Use Of Lidocaine And Procainamide, J. Thomas Bigger Jr., Elsa-Grace V. Giardina

MCV/Q, Medical College of Virginia Quarterly

Both procainamide and lidocaine are useful for acutely treating cardiac arrhythmias, and procainamide can be useful in chronic antiarrhythmic regimens. Successful management of cardiac arrhythmias requires knowledge of: 1) the mechanism and natural history of the arrhythmia, 2) the physiologic state of the patient, and 3) the cardiac effects, pharmacodynamics, and general pharmacology of the antiarrhythmic drugs.


Author Index, Volume Nine, 1973 Jan 1973

Author Index, Volume Nine, 1973

MCV/Q, Medical College of Virginia Quarterly

Author index for MCV/Q, Medical College of Virginia Quarterly, 1973, Volume Nine.


Recent Studies In The Pre-Excitation Syndrome, E. Neil Moore Jan 1973

Recent Studies In The Pre-Excitation Syndrome, E. Neil Moore

MCV/Q, Medical College of Virginia Quarterly

The Wolff-Parkinson-White syndrome has held an unusual fascination for cardiologists ever since its original description in 1930. Over 60 different theories have been postulated to describe the mechanism of pre-excitation. The recent development of epicardial mapping techniques to define the sequence of ventricular activation, and the introduction of His bundle electrocardiography have provided valuable procedures for studying pre-excitation. This presentation will discuss some of the insights into the mechanism of pre-excitation that have been derived from these two electrophysiological procedures.