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Book Review, Frederick J. Spencer

MCV/Q, Medical College of Virginia Quarterly

Book reviews for Epidemics, Geoffrey Marks and William K. Beatty, Scribner's, 1976 and Plagues and Peoples, William H. McNeill, Doubleday, 1976.

Introduction, David B. Walthall Jr.

MCV/Q, Medical College of Virginia Quarterly

This issue of the MCV Quarterly is devoted to the 48th Annual McGuire Lecture Series held on February 12-13, 1977. The lectures, presented this year by the Department of Continuing Education, were designed to focus upon the ever-increasing amount of new information being generated in the field of immunology.

Coma In Infancy And Childhood, Edwin C. Myer

MCV/Q, Medical College of Virginia Quarterly

Coma is defined as an altered state of consciousness from which arousal due to appropriate stimuli is not adequately achieved. Such a definition of the state of coma is plagued with semantic problems, and terminology describing various comatose states is vast and even more ambiguous when applied to the infant. Rather than using such terms as coma, semicoma, stupor, or obtundation, it is better to describe the physical state of the unresponsive patient. The description should include the patient’s appearance, movements either spontaneous or elicited from stimuli, the patient’s response to the stimulus, and the nature of the stimulus, whether …

Acute Seizure Problems, Cary Suter

MCV/Q, Medical College of Virginia Quarterly

Seizures are a symptom and not a disease. A seizure is the result of an abnormal electrical discharge of a collection or group of living but damaged or abnormal neurons. When the group of neurons is in the cerebral cortex, a focal or partial seizure occurs, producing abnormal activity related to that part of the brain. The victim may experience a focal jerking or focal numbness, or flashing lights if the lesion is in the occipital lobe; or he or she may be subject to peculiar automatic behavior if the lesion is in the temporal lobe. When the activity spreads …

Bacterial Meningitis: Some Epidemiologic And Clinical Factors In Diagnosis, Vincent P. Calabrese

MCV/Q, Medical College of Virginia Quarterly

In ancient times all acute delirium states were known as “phrenesis.” It was not until the 17th century that inflammations of the meninges and cerebrum were differentiated from each other. By the 19th century meningitis had been described to the extent that a number of epidemics were reported both in the United State and Europe, but it was the development of the lumbar puncture by Quincke in 1893 which opened up a new diagnostic era for the disease.

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1977, Volume Thirteen, Number Four.

Juvenile Hyperlipemia, William W. Miller

MCV/Q, Medical College of Virginia Quarterly

Asymptomatic hyperlipemia occurs in a significant number of American children. It is important to recognize the condition during childhood because of its role as a risk factor in the early onset of coronary artery disease and because early dietary modification may prevent changes leading to premature heart disease.

Genetic Studies Of Deafness And Of Retinitis Pigmentosa, Joann A. Boughman, Frederick R. Bieber, Walter E. Nance

MCV/Q, Medical College of Virginia Quarterly

In experimental animals where the generation time is short and matings can be controlled experimentally, it is a relatively simple task to determine whether a trait is genetic, how it is inherited, and where the causal gene pair is located. However, in human genetics, inferences must be drawn by pooling observations on many small families in which the trait of interest has occurred. The condition may be etiologically heterogeneous, resulting from environmental causes in some families and showing variable patterns of inheritance in others. Hereditary deafness and retinitis pigmentosa (RP) provide instructive examples of the problems involved in the genetic …

The Genetic And Environmental Effects On Diabetes In Humans And Animals: An Overview, Roger M. Loria, Linda A. Corey

MCV/Q, Medical College of Virginia Quarterly

Despite intense scrutiny the precise etiology of diabetes mellitus remains unclear. There appear to be two major forms of diabetes: juvenile-onset or insulin-dependent diabetes, and late-onset or insulin-independent diabetes; the late-onset form, in itself, may be etiologically heterogeneous. Either form may occur at any age, with a clear distinction between the two often being difficult to make. Juvenile-onset diabetes, representing 5% to 10% of all cases, is characterized by abrupt onset, clinical manifestation of hyperglycemia and ketoacidosis, and generally by a requirement for exogenous insulin; in maturity-onset diabetes plasma levels of insulin are usually normal or elevated and the abnormality …

Table Of Contents, Volume Thirteen, 1977.

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1977, Volume Thirteen.

Virginia Dental Journal (Vol. 54, No. 1, 1977)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 54, No. 6, 1977)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 54, No. 2, 1977)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 54, No. 3, 1977)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 54, No. 4, 1977)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 54, No. 5, 1977)

Virginia Dental Journal

No abstract provided.

Interactions Of Ethanol And Methadone, Vijay Aggarwal

Theses and Dissertations

The effects of ethanol administration on the antinociceptive activity, lethal properties and brain concentration of methadone, were investigated. The effect of ethanol on the antinociceptive activity of methadone was assessed by the hot-plate and tail-flick tests. Concentrations of methadone in the brain were determined by the use of 3H-methadone as well as by gas liquid chromatographic analysis. The study showed that moderate doses of ethanol did not alter tail-flick or hot-plate response by themselves. However, when combined with methadone, ethanol produced a significant increase in the antinociceptive effectiveness of methadone as measured by both a decrease in the ED50 of …

A Study Of The Identification Of Medically Important Streptococci, Margaret Antoinette Hardy

Theses and Dissertations

Summary:

1. The type of animal blood used in preparing blood agar plates did not significantly affect the demonstration of hemolysis by any streptococcal species except for S.faecalis. S.faecalis more consistently displayed an alpha reaction on sheep blood agar while expressing a beta reaction on horse and rabbit blood agars.

2. A recommended scheme for identifying streptococci, adaptable to most any clinical laboratory, was developed and is outlined in Table 13.

3. S.agalactiae (group B) was the most frequent beta hemolytic streptococcal isolant. Significantly, it was the only species over-all to be recovered from every clinical source. The CAMP test …

Table Of Contents, Volume Twelve, 1976.

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1976, Volume Twelve.

Introduction, John R. Taylor

MCV/Q, Medical College of Virginia Quarterly

We conclude our two-part issue on Neurology for Primary Care Physicians with both the new and the old. Attempting to avoid repetition, our authors address themselves to the overlooked, under-emphasized, and sometimes new area of familiar subjects. Our guest speakers, Dr. Millikan and Dr. Horenstein discuss acute cerebral infarction and the perennial problem of dementia. Exciting new fronts are explored by Drs. Isaacs and Sakalas as they expand on their ideas on neuromuscular disease and surgical techniques for extra-intracranial oscular anastomoses, respectively. Dr. Selhorst contributes some interesting views on low back problems.

New Horizons In Muscle Disease, Edward R. Isaacs

MCV/Q, Medical College of Virginia Quarterly

Sophisticated physiological and histochemical information is accumulating at a rate which at present is faster than the clinician can assimilate. The contributions made by electron microscopy further burden an overwhelming stockpile of data. In a true sense, many pieces to the puzzle have been found, and as these are cautiously put in place, a more complete understanding of muscle disease is foreseeable. One hopes that with better insight into the pathophysiology of muscle diseases, these new horizons will permit eventual treatment or cure for those suffering from these disorders.

Uncommon Disorders Of The Lower Spinal Region A Report On Eleven Patients, John B. Selhorst

MCV/Q, Medical College of Virginia Quarterly

Prompt diagnosis of lower spinal diseases is essential for successful treatment. Appropriate medical therapy or surgical decompression arrests progression and reverses existing neurologic deficit. Delayed or improper diagnosis seriously jeopardizes the patient’s ultimate neurologic status. Too often early symptoms are disregarded or passed over as insignificant.

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1976, Volume Twelve, Number One.

Acne Vulgaris, James J. Leyden

MCV/Q, Medical College of Virginia Quarterly

Acne vulgaris displays all the characteristics of a polygenic disorder in that hereditary factors are apparent with strong family tendencies for the disorder while the phenotypic expression of the disease varies over a wide spectrum. All that is known for certain concerning the genetics of acne is that concordance is extremely high in identical twins. In the past decade, various investigations have resulted in much clearer concepts of pathogenesis and have brought us to the point of effective therapy for the majority of cases. In this report, I will summarize recent concepts in the pathogenesis of acne vulgaris.

Paleoserologic Studies: Abo And Histocompatibility Antigens In Mummified American Indians, A. A. Hossaini, Marvin J. Allison

MCV/Q, Medical College of Virginia Quarterly

The first genetic polymorphism to be described in man was the ABO blood group system. Ths system proved to be present as a membrane antigen of the cells of almost all organs of the body. In this it not only stimulates histocompatibility antigens but also helps to determine ABO compatibility between organ recipients and their donors. The presence of the ABH and HL-A antigens in tissues and their stability on storage allows typing mummified bodies despite the passage of thousands of years.

Treatment Of Head Wounds In Pre-Columbian And Colonial Peru, Marvin J. Allison, Alejandro Pezzia

MCV/Q, Medical College of Virginia Quarterly

As is frequently the case, art objects often depict the life in a particular civilization, thus giving a visual record of a people where the people themselves have disappeared. Peru is one of the areas of the world where art depicts the life of the people while the people themselves are present in the form of mummies to confirm much of what is seen in art. A number of ceramic vessels have been found depicting one man working on the skull of another with a knife. That such actions were possibly surgical was documented in 1865 when Squier was given …

Introduction, John R. Taylor

MCV/Q, Medical College of Virginia Quarterly

The 29th Annual Stoneburner Lecture Series was sponsored this year by the Department of Neurology because we sensed a need and a desire for a symposium approaching common neurologic problems encountered by primary care physicians. The attendance at the series was gratifying to the participating lecturers and confirmed our view.

Episodic Disorders Of Vision, John W. Harbison

MCV/Q, Medical College of Virginia Quarterly

Of all our senses, vision is most commonly associated with patient distress, if not overt alarm, when abruptly compromised. Despite patient concern, a rare, or rarely recognizable, clinical entity is perhaps of less significance to the physician than to the patient. When the broad spectrum of episodic disturbance of vision is closely examined, it becomes apparent that these visual symptoms are indeed of common occurrence in the population at large. Surprisingly, despite their ultimate effect on the eye, a majority of the clinical entities that produce episodic disturbance of vision are neurologic. Episodic is defined as being "...made up of …

Inadequate Parathyroid Response In Acute Pancreatitis, Giles M. Robertson , Jr., M.D., Edward W. Moore , M.D., Donald M. Switz , M.D., Glen W. Sizemore , M.D., Herschel L. Estep , M.D.

Internal Medicine Publications

Abstract

We studied nine consecutive hypocalcemic patients with acute pancreatitis to elucidate the mechanism of hypocalcemia. Mean serum ionized calcium, 0.97 mM, was below the normal mean of 1.16 mM (P < 0.001). Seven of eight patients tested had normal parathyroid hormone levels. All responded to parenteral parathyroid extract by increasing serum ionized calcium and urinary cyclic AMP, indicating parathyroid-hormone-responsive target organs. Calcitonin and glucagon concentrations were increased above normal in some patients, but there was no relation with serum ionized calcium. Parenteral glucagon had no significant effect on serum ionized calcium or calcitonin concentrations. These findings suggest that neither glucagon nor calcitonin was primarily responsible for the hypocalcemia, which did not produce expected increases in serum parathyroid hormone concentrations. Relative parathyroid insufficiency may account for the persistent hypocalcemia frequently observed in patients with acute pancreatitis. (N Engl J Med 294:512–516, 1976)

Thyroid Diseas In A Peruvian Mummy, Enrique Gerszten, Marvin J. Allison, Alejandro Pezzia, David Klurfeld

MCV/Q, Medical College of Virginia Quarterly

Although the pathogenesis of endocrine disorders has only recently been recognized, disorders of the thyroid gland have been recorded since ancient times, primarily because of the gland’s strategic location in the neck. Goiter, enlargement of the gland, was described early in history and endocrine goiter was also mentioned. The earliest written references go back as far as the Chinese of the second millennium BC, Greek and Roman authors of classical times, and medieval manuscripts. In his history of goiter, Greenwald contended that there was no evidence of goiter in the Americas before the coming of the white man, although the …