Medicine and Health Sciences Commons^™

Cervical Cytology And Colposcopy, W. Glenn Hurt

MCV/Q, Medical College of Virginia Quarterly

Colposcopy was first described by Hinselmann of Hamburg in 1925. The colposcope is a binocular microscope of low power (10x to 25x) which contains a light source and is mounted on a stand to permit its use in the study of the surface of the uterine cervix. Using the colposcope, the physician can identify and evaluate cervical epithelial abnormalities.

Virginia Dental Journal (Vol. 57, No. 4, 1980)

Virginia Dental Journal

No abstract provided.

The Location Of Olfactory Receptor Sites. Inferences From Latency Measurements, T. V. Getchell, G. L. Heck, J. A. Desimone, S. Price

Physiology and Biophysics Publications and Presentations

Excitatory responses recorded from vertebrate olfactory sensory neurons are characterized by long latencies compared with those from other sensory receptors. Explanations which assume free access of the stimuli to receptor molecules presumably located on the olfactory cilia necessarily imply an intrinsic delay in the transduction mechanism. In contrast, the possibility of restricted or delayed access due to diffusion of the stimulus to molecular receptors located on the dendritic knob or proximal portions of the cilia suggests transduction processes having time courses similar to those in other sensory systems. We show that the threshold stimulus concentration and the latency of the …

Investigation Of A Factor Released By Neoplastic Cells Which Produces A Chemokinetic Response In Activated Macrophages, Richard Durelle Lane

Theses and Dissertations

The increase in rate of random migration (chemokinesis) of C. parvum activated macrophages in media conditioned by Lewis Lung (LL) carcinoma cells was attributed to a trypsin sensitive, heat stable, high molecular weight factor released from the membrane of the tumor cells.

A capillary tube assay was developed to expediently monitor the chemokinetic activity of macrophages incubated in whole and fractionated media. The capillary tube assay was found to be capable of detecting both chemokinetic and chemotactic (directional movement) factors present in the test media. Statistical analysis revealed the capillary tube assay provided reproducible data both within and between experiments. …

The Effect Of Three Different Types Of Feedback On The Amount Of Force Generated During Isometric Contraction Of The Triceps Brachii Muscle, Cindy I. Buchanan

Theses and Dissertations

This study was undertaken in order to investigate the effect of different feedback variables on isometric strength performance. The variables studied were auditory EMG biofeedback, knowledge of results, and verbal cues.

Nineteen normal adult women volunteered as subjects for the study. Each subject performed nine isometric contractions of the triceps brachii muscle against the resistance of a cable tensiometer. One of three different types of feedback was given during each contraction in order to motivate subjects to generate as much force as possible. Feedback variables were applied in random order; each variable was used three times. Peak force readings were …

The Relationship Between Self-Esteem And Duration Of Low Back Pain, Betty Sue Holliday Ashby

Theses and Dissertations

The purpose of this study was to explore the relationship between self-esteem and duration of low back pain. Low back pain is one of the most common types of chronic pain. Sternbach et al. (1973) have estimated that the chief complaint of at least seventy percent of the patients presenting at the Pain Clinic associated with the School of Medicine of the University of California, San Diego is back pain. They feel that the major reason for this phenomena is the failure of physicians to recognize it as a psychosomatic illness. Erena (1978) concurs with this conclusion. He notes that …

Regulation Of Cartilage Acid Hydrolases And Their Relationship To Skeletal Growth, John Richard Hubbard

Theses and Dissertations

The in vivo regulation of several acid hydrolases by growth hormone was investigated in an attempt to lend insight into the mechanism of growth hormone action. In addition, the relationship of these enzymes to age-dependent changes in skeletal growth rate was examined. Initial studies showed that hypophysectomy reduced the activity of an unknown cartilage protease, which was assayed by digestion of gelatin-membrane substrates at pH 4.0. Treatment of hypophysectomized rats with growth hormone enhanced this activity to about normal levels. The unidentified protease activity was also shown to be higher in younger, more rapidly growing rats, than in older, less …

Comparison Of Burned Patients' Perception Of Pain With Nurses' Perception Of Patients' Pain, Merri Diane Walkenstein

Theses and Dissertations

Pain is a universal experience. Caring for people in pain is a central aspect of nursing practice. Many studies have been done to determine the physical and psychosocial mechanisms of the pain sensation, in addition to methods of relief. Very little has been done, however, dealing specifically with the pain experienced by the burned patient.

People hospitalized with thermal injuries complain most often of the intensity and long duration of their pain experience. Due to the large number of persons sustaining thermal injuries every year, it is apparent that nurses must familiarize themselves with methods of evaluation and intervention to …

Virginia Dental Journal (Vol. 57, No. 3, 1980)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 57, No. 1, 1980)

Virginia Dental Journal

No abstract provided.

Loneliness: A Study Of Adult Clinic Patients With Metastatic Cancer, Katherine Norfleet Berry

Theses and Dissertations

Loneliness is a topic of growing concern in the literature. Despite inherent difficulties in measuring such a personal experience, the present study was undertaken in order to gain knowledge concerning emotional needs of the dying cancer patient.

The conceptual frameworks for loneliness of Francis and Brown were combined and added to Bowen’s theory of “family reaction to death” to formulate the framework for this research. The relationship of secondary loneliness among adult clinic patients with metastatic cancer, and openness of their relationship system with a significant other was explored using the structured interview method. The loneliness scale and relationship system …

The Effects Of Prepared Childbirth On Length Of Labor In Low-Risk Primiparae, Beth S. Mollick

Theses and Dissertations

The hypothesis that prepared low-risk primiparae would experience shorter labors than unprepared low-risk primiparae was not upheld in the findings of the present study. The findings of the present study did appear to validate the findings of several other similar studies which reported no differences in length of labor between prepared and unprepared women. Suggestions for further study of some questions raised by the present study have been made.

Clean Technique Intermittent Catheterization As An Alternative To The Indwelling Urethral Catheter, Christine Heuston Lessels

Theses and Dissertations

Research has documented numerous risks and complications in the use of indwelling urethral catheters.¹ In spite of this, indwelling catheters are still widely used for the management of incontinence.²

During the past four decades, studies have shown that incontinence can be managed or resolved in many patients by using intermittent catheterization. Early investigators used elaborate sterile technique and included only patients with neurogenic bladder as a result of spinal cord injury.³ Later studies showed favorable results in patients with incontinence of non-traumatic etiology--even in patients previously dependent on an indwelling urethral catheter.⁴ The early literature on …

The Relationship Between Maternal Self-Concept And Demonstration Of Adaptive Behavior, Barbara Woodland Fleming

Theses and Dissertations

The study examined whether adaptive maternal behaviors correlated with a positive self-concept measurement. The adaptive behaviors observed were those which the literature suggested indicate a positive response to the changes of the puerperium. The study aimed at assisting the nurse in assessing the self-concept level of clients. The researcher also hoped to contribute to the continued development of nursing theories and the application of the theories to the arena of clinical practice.

Introduction, David W. Richardson

MCV/Q, Medical College of Virginia Quarterly

The 50th McGuire Lecture Series presented current reviews in clinical cardiology and hypertension for practicing physicians and medical students. Speakers were members of the faculty of the Divisions of Cardiology and Cardiovascular Surgery at the Medical College of Virginia and Dean T. Mason, M.D., Chief of the Cardiovascular Section at the University of California at Davis. Dr. Mason, who is the outstanding authority on the management of congestive heart failure by reduction of the load against which the heart must pump, was the McGuire Lecturer.

Indications For Cardiac Catheterization In The Diagnosis And Management Of Coronary Artery Disease, George W. Vetrovec

MCV/Q, Medical College of Virginia Quarterly

In 1979 coronary angiography remains the standard test for diagnosing the presence and extent of coronary artery disease. Non-invasive studies such as exercise testing are only relative predictors of coronary anatomy. Therefore, to define specifically whether or not coronary disease exists in a given patient and, if present, to delineate its location, severity and the potential for bypass surgery, a coronary angiogram is the test to obtain. The purpose of this paper is to discuss indications for coronary angiography in the management of patients with established or suspected coronary disease.

Recent Advances In The Management Of Chronic Airway Obstruction, James A. L. Mathers Jr.

MCV/Q, Medical College of Virginia Quarterly

Recent advances in our understanding of the natural history of chronic airway obstruction have identified aspects of this process that may enhance the morbidity and mortality of patients with a progressive increase in airway resistance. These advances have helped us to be more specific in the investigation and quantitation of the disease in the pulmonary function laboratory and to be more precise in our therapeutic management. Experience has taught us that the most useful measurement with which to characterize the degree of disease and its rate of progression is the forced expired volume in one second (FEV1). The comprehensive studies …

Introduction, Edwin C. Myer

MCV/Q, Medical College of Virginia Quarterly

Many theories have been expounded as to the cause of Sudden Infant Death, not the least of which are those reports in the newspapers. This symposium covers the problem of etiology, pathophysiology, and the recognition of the at-risk infant, the management of the Sudden Infant Death victim, parents and the family, was well as efforts to prevent the occurrence of this event.

The Parents' Reaction, Suzanne Rowdon

MCV/Q, Medical College of Virginia Quarterly

As I sit here it appears to me that most you are aware of SIDS through your profession and education. My awareness came like a lightning bolt one sunny afternoon when I was getting ready for Thanksgiving dinner. It left a wound that is very slow to heal and my reaction from that continues to this day.

Emergency Room Procedure, David A. Draper

MCV/Q, Medical College of Virginia Quarterly

After having sat here and listened to the panel and particularly to Sue Rowdon describe her experience with her child’s death, I think it has been amply explained what emergency room procedure ought to be. Obviously, there has to be someone to take responsibility for evaluating the infant, and generally that person is going to be a physician. At the same time there has to be someone who can be attentive and compassionate to the family. The physician needs to recognize and explain some of the thoughts that must be going through the parents’ minds, such as, What’s wrong? What’s …

The Counseling Visit

MCV/Q, Medical College of Virginia Quarterly

The counseling opportunity for the health professional is generally referred to as the “home visit.” While the most valuable setting for assistance to the family is probably within the home setting, it should be recognized that other areas or settings can be utilized. Periodically, the telephone may be the only means of reaching the family. The decision as to where the counseling visit should take place rests with the family and the counselor. The counseling visit is an option for the family and may be refused by them. It is suggested that families in a period of grief do not …

Volume Fifteen Table Of Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1979, Volume Fifteen.

Volume Fifteen Author Index

MCV/Q, Medical College of Virginia Quarterly

Author Index for MCV/Q, Medical College of Virginia Quarterly, 1979, Volume Fifteen.

Early Diagnosis Of Relapse In Acute Myeloblastic Leukemia — Serologic Detection Of Leukemia-Associated Antigens In Human Marrow, Michael A. Baker , M.D., Judith A. Falk , B.Sc., Walter H. Carter , Ph.D., Robert N. Taub , M.D., Ph.D.

Internal Medicine Publications

Abstract

We tested serial bone-marrow samples from 47 adults with acute myeloblastic leukemia in remission for reactivity with heteroantiserums to leukemia-associated antigens, to determine whether imminent relapse could be detected in patients with acute leukemia. Of 26 patients who relapsed by standard morphologic criteria, 21 had increased immunoreactivity of bone marrow for one to six months (mean, 3.7 months) before relapse. High concordance was observed between a positive test and relapse during the period of study (chi-square = 27.53, P

Human Infection From An Unidentified Erythrocyte-Associated Bacterium, Gordon L. Archer , M.D., Philip H. Coleman , D.V.M., Ph.D., Roger M. Cole , M.D., Ph.D., Richard J. Duma , M.D., Ph.D., Charles L. Johnston , Jr., M.D.

Internal Medicine Publications

Abstract

A 49-year-old splenectomized man had an infection from an unidentified, gram-positive, rodshaped bacterium that adhered to the majority of his peripheral-blood erythrocytes. On transmission electron microscopy, the bacterium was seen to be extraerythrocytic and was 0.2 μm wide by 1.0 to 1.7 μm long. It possessed a thick, granular cell wall, a trilamellar membrane external to the cell wall and prominent mesosomes. Attempts to cultivate the organism in vitro or to duplicate the patient's disease in splenectomized animals were unsuccessful. The patient's response suggested that the bacterium was susceptible to cell-wall-active antibiotics and to chloramphenicol but not to tetracycline. …

A Comparison Of Amphotericin B Alone And Combined With Flucytosine In The Treatment Of Cryptoccal Meningitis, John E. Bennett , M.D., William E. Dismukes , M.D., Richard J. Duma , M.D., Gerald Medoff , M.D., Merle A. Sande , M.D., Harry Gallis , M.D., John Leonard , M.D., Branch T. Fields , M.D., Major Bradshaw , M.D., Hubert Haywood , M.D., Zell A. Mcgee , M.D., Thomas R. Cate , M.D., C. Glenn Cobbs , M.D., John F. Warner , M.D., David W. Alling , M.D., Ph.D.

Internal Medicine Publications

Abstract

We compared amphotericin B therapy for cryptococcal meningitis with a newer regimen containing both amphotericin B and flucytosine. In 50 patients with 51 courses of therapy adherent to the protocol, 27 courses were with amphotericin B and 24 with the combination. Even though the combination regimen was given for only six weeks and amphotericin B for 10 weeks, the combination cured or improved more patients (16 vs. 11), produced fewer failures or relapses (three vs. 11), more rapid sterilization of the cerebrospinal fluid (P<0.001) and less nephrotoxicity (P<0.05) than did amphotericin B alone. The number of deaths was the same (five) with each regimen. Adverse reactions to flucytosine occurred in 11 of 34 patients but were not life threatening. We conclude that combined flucytosine-amphoericin B therapy is the regimen of choice in cryptococcal meningitis. (N Engl J Med 301:126–131, 1979)

[Beta]-(2-Hydroxyphenyl)Ethanolamine Hydrochloride [2-Amino-1-(2-Hydroxyphenyl)Ethanol Hydrochloride], Alexandros Makriyannis, James B. Anderson, Joseph T. Dipiro, Edward Kostiner, Gilbert Hite

Publications from the Office of the Dean

CsH~2NO2+.C1 -, m.p. 441-449 K (from ethyl acetate), P212~2 l, a = 7.363 (2), b = 21.824 (6), c = 5.790 (2)/~, Z = 4, D x = 1.354, D m = 1.356 Mg m -3 (flotation: CC14-C6H6). The structure was solved by MULTAN. Full-matrix least-squares refinement converged to R = 0.057 for the R configuration and to R = 0.056 for the S configuration (P < 0.05). This is consistent with spontaneous resolution of the title compound, single crystals of which provided optically active aqueous solutions. A partially occupied oxygen site O(1)' is attributed to the oxidation of the alkyl hydroxyl group to a ketone during the data collection. The CI- is hydrogen bonded to H2(N)554, H3(N)555, and 1-t(O2)655 (2.37, 2-19, and 2.10 A). Both O(1) and 0(2) are internally hydrogen bonded [HI(N)...O(1), 2.41 and H(O1)...O(2) = 2.24 A]. Intramolecular hydrogen bonding may account for the unusual pharmacological properties of this compound in which only the N-C(1)-C(2)-O(1) and the O(1)-C(2)- C(3)-C(4) and O(1)-C(2)-C(3)-C(8) torsion angles (-41, -60, +122 ° ) differ significantly from those of other phenylethanolamines.

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1979, Volume Fifteen, Number One.

Afterload Reduction Therapy For Congestive Heart Failure, Dean T. Mason

MCV/Q, Medical College of Virginia Quarterly

The most important recent advance in the medical management of patients with acute and chronic congestive heart failure has been the application of systemic vasodilator drugs to reduce ventricular afterload, thereby improving low cardiac output and decreasing increased venous pressure. Although such drugs have been employed for several years to treat essential hypertension, hypertensive heart failure, acute hypertensive crises, and angina pectoris, only in the past five years has their use become widely popular in the therapy of normotensive heart failure. While it can be reasoned that the vasodilator approach is a logical therapeutic extension of fundamental determinants regulating cardiac …

Diseases Which Mimic Asthma And Chronic Obstructive Pulmonary Disease (Copd), George W. Burke Iii

MCV/Q, Medical College of Virginia Quarterly

The American Thoracic Society defines asthma as a disease characterized by increased responsiveness of the trachea and bronchi to various stimuli and manifested by widespread narrowing of the airways that changes in severity either spontaneously or as a result of therapy. In this context asthma is a physiologic diagnosis. It is most often recognized when a patient complains of episodic wheezing and dyspnea and most often confirmed by the demonstration of variable airways obstruction on spirometric testing.