Medicine and Health Sciences Commons^™

Synthesis And Biological Evaluation Of Sparsomycin Analogues, Scherer Preston Sanders

Theses and Dissertations

In 1962, Owen, Dietz, and Camiener reported the isolation of a new antitumor antibiotic from the culture filtrate of Streptomyces sparsogenes. The structure of the crystalline antibiotic, named sparsomycin, remained elusive until 1970, when Wiley and MacKellar reported results of spectroscopic and degradation studies which elucidated the structure. In addition to the molecular structure, investigators have examined the mechanism of action, toxicity, and related analogues, striving to establish sparsomycin or a synthetic analogue's usefulness as an effective chemotherapeutic agent.

The initial pharmacological evaluation of sparsomycin revealed it possessed activity against KB human epidermoid carcinoma cells, a variety of gram-negative and …

An Evaluation Of A Coronary Education Program, Anne Broaddus Sydnor

Theses and Dissertations

This study was conducted to evaluate a Coronary Educational Program at a 350 bed community suburban hospital. The five year old program has never been evaluated. The evaluation was limited to one product of the program, the change in patient knowledge relative to their disease. Subjects also completed a subjective evaluation of the program, including the content areas, teaching methods, and competence of the instructors.

Twelve subjects participated during the 2% month study. They consisted of 10 males and 2 females; 11 Whites and 1 Black. The age range was 53 to 76 years, with a mean of 63.9 years. …

Virginia Dental Journal (Vol. 58, No. 1, 1981)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 58, No. 2, 1981)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 58, No. 6, 1981)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 58, No. 4, 1981)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 58, No. 5, 1981)

Virginia Dental Journal

No abstract provided.

Comparison Of The Behavioral Pharmacology Of Phencyclidine To Related Compounds, Kathleen T. Brady

Theses and Dissertations

Phencyclidine (PCP) belongs to a class of drugs with a unique and characteristic spectra of pharmacological activity. PCP has recently become a major drug of abuse. Structural analogues of PCP have also been reported in street use. The following experiments explore the behavioral pharmacology of PCP and several compounds with PCP-like activity.

In Experiment I the effects of PCP were compared to three structural analogues in rhesus monkeys trained to lever press on a fixed-interval 5 min schedule of food presentation. Dose-response curves and potency estimates were determined for PCP, N-ethyl-1-phenylcyclohexylamine (PCE), 1-(1-(2-thienyl) cyclohexyl) piperidine (TCP) and ketamine.The effects of …

Self-Perceived Needs Of Adult Males And Their Significant Others Following Colostomy For Colo-Rectal Cancer, Derry Ware

Theses and Dissertations

In spite of continuing advances in diagnostic methods, surgical and medical management, and psychological care, cancer remains the second leading cause of death among adults in the United States (American Cancer Society, 1980), and it continues to engender feelings of futility in its victims and the general population as well. Between 1970 and 1980 more than 6.5 million new cases of cancer were diagnosed, and more than 10 million people were under medical treatment for the disease. There are over 3 million Americans presently alive who have a history of cancer (American Cancer Society, 1980). Approximately 15 percent of all …

An Analysis Of The Effect Of Immediate Corrective Feedback Administered As A Study Aid To Undergraduate Medical Technology Students, Constance Anne Bak

Theses and Dissertations

Twenty-six undergraduate medical technology students at Virginia Commonwealth University were provided with a Hemestasis Study Guide to use during this unit and in preparing for an exam in this area. The study guide contained fifty objective-related questions in multiple-choice format. Answers were printed in latent image and included positive reinforcement for correct selections and remediation for incorrect ones. Thus the student received immediate feedback concerning his response to each question.

An examination grade continuum was plotted for this class utilizing all exam grades in the Hematology course. A similar continuum was plotted for each of the three previous classes. (These …

The Relationship Between A Patient's Stress Level During Hospitalization And His Perception Of His Significant Family Member's Role In Providing Support, Susan Carey Williams Johnson

Theses and Dissertations

A descriptive study was undertaken to investigate the relationship between a patient's stress level during hospitalization and his perception of his significant family member's role providing support. The following subproblems were also addressed:

(1) What types of activities, presently or potentially performed by a significant family member, does the patient perceive as supportive?

(2) What types of nursing activities, as perceived by the patient, are being done to encourage/discourage performance of family support activities?

(3) What other factors does the patient perceive as encouraging/discouraging performance of these family role-related activities?

The Hospital Stress Rating Scale (Volicer and Bohannon, 1975) was …

The Relationship Between Self-Concept And Locus Of Control In Physically Abused Women, Betsy Wright Shires

Theses and Dissertations

History can provide some clues concerning the physical abuse of women by men. Beginning in biblical times, women were viewed as the property of men (Steinmetz, 1977). Until 1824 by law, a man was allowed to strike his wife if provoked (Bell, 1977). Under the law, some states still grant "spouse immunity" in cases of assault and battery, where married couples are involved.The focus of this research was to examine the problem of wife abuse through the perspective of social learning theory. Using Roy's theory of adaptation (Roy, 1976), the investigator also examined the area of self-concept as it related …

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 15 No. 4

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

Antenatal Genetic Studies, Fay Redwine

MCV/Q, Medical College of Virginia Quarterly

The Antenatal Genetic Testing Program at MCV began in 1973. The standard scheme for antenatal genetic testing involves counseling, the methods of carrier detection available, ultrasound, amniocentesis, and laboratory evaluation. Patients are referred because of a family or personal history of a genetic abnormality or because they have been evaluated in a carrier detection program like those for Tay-Sachs disease or Sickle Cell disease and are known carriers. After referral, patients are given genetic counseling by me and members of the Department of Human Genetics; if antenatal genetic testing is deemed appropriate, we obtain informed consent and proceed with an …

Evaluation And Management Of Adnexal Masses, Dean R. Goplerud

MCV/Q, Medical College of Virginia Quarterly

The adnexa are those structures which lie along the uterus, the most important of which are the tubes and ovaries. The portions of the broad ligaments and mesosalpinx which contain embryonic remnant may also, at times, be palpable and therefore must be considered in any differential diagnosis.

Some Psychological Aspects Of Dealing With Cancer, Joel J. Silverman

MCV/Q, Medical College of Virginia Quarterly

Cancer has a potentially profound affect upon the emotional and physical life of the patient and his or her family. For most people the word “cancer” has a fearsome connotation. This discussion explores the areas of self-image, body-image, and personal relationships that are often altered in cancer patients, as well as the emotional and cognitive states which can result from malignancy and its treatment. We will also review some techniques for helping the patient. It is important to remember that the psychological responses to any illness are individual and largely determined by the patient’s past experience, psychological strengths, weaknesses and …

Menstrual Abnormalities, Leo J. Dunn

MCV/Q, Medical College of Virginia Quarterly

Any physician involved in primary care will encounter patients with menstrual dysfunction. Mismanagement of this disorder is not usually the result of its complexity but rather the lack of an orderly approach. In unusual circumstances one may encounter a patient with a menstrual disorder of sufficient complexity to require referral. This decision should be based on a work-up indicating such a need rather than frustration after unsuccessful empiric therapeutic trials.

Identification Of The High-Risk Gravida, Robert E. Petres, Emily M. Coogan

MCV/Q, Medical College of Virginia Quarterly

In the past, there has been considerable pessimism about our ability to identify the pregnant patient at risk. However, with the development of sophisticated diagnostic techniques these patients can be identified and with appropriate treatment their outcome can be improved. This paper presents the overall benefit of categorizing obstetrical patients, the method that has been developed at the Medical College of Virginia (MCV), and certain categories of high-risk obstetrical patients who continue to present problems and have unacceptably high complication rates.

Endometriosis, W. Glenn Hurt, Ray A. Wetheim

MCV/Q, Medical College of Virginia Quarterly

Endometriosis is diagnosed when tissue which resembles the endometrial lining exists outside the endometrial cavity. Although first described as a pathological entity in the late 1800s, the term “endometriosis” was not introduced until the early 1920s by Sampson. The great volume of literature which has accumulated on this topic is, by and large, a product of the 20th century.

Office Endometrial Sampling, Stephen A. Cohen, W. Glenn Hurt

MCV/Q, Medical College of Virginia Quarterly

The concept of office endometrial sampling is not new. Kelly recommended its use in 1925. More recently, the procedure has received increased attention as physicians and the public have sought ways to curb the spiraling cost of medical care. Uterine curettage is the operation most commonly performed on women throughout the world. As an inpatient procedure, it costs $500 to $600. The same procedure performed in an outpatient surgical center costs $350 to $400. In over 90% of cases, an adequate endometrial sample may be obtained in the office at a cost of $50 to $60. For office endometrial sampling …

Introduction, W. Glenn Hurt

MCV/Q, Medical College of Virginia Quarterly

The Department of Obstetrics and Gynecology welcomed the opportunity to present the 51st Annual McGuire Lecture Series. The lectures were designed to provide the primary care physician with information which is clinically useful and applicable to the daily practice of obstetrics and gynecology. An effort was made to achieve a balance between those health problems that have been known for some time but whose understanding has changed and those problems that have been recognized more recently and whose solutions are still evolving.

Urinary Incontinence In Women, J. Andrew Fantl

MCV/Q, Medical College of Virginia Quarterly

The adult bladder and urethra acting as a unit allow for the voluntary dual function of urine collection and evacuation. Urinary continence is an acquired, “learned” state, and normal anatomy and function of the nervous and genitourinary systems are necessary to maintain it. Urinary incontinence is defined as “a condition where involuntary loss of urine is a social or hygienic problem and is objectively demonstrable.” This definition takes into account both sociocultural aspects and the need for objective clinical assessment of urinary leakage. Marked individual variations in physical activity, occupation and hygienic standards call for appropriate clinical judgment when evaluation …

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1980, Volume Sixteen, Numbers One and Two.

Virginia Dental Journal (Vol. 57, No. 5, 1980)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 57, No. 2, 1980)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 57, No. 6, 1980)

Virginia Dental Journal

No abstract provided.

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 16 No. 1

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

Management Of High-Risk Gravida, Shelby Jarrell

MCV/Q, Medical College of Virginia Quarterly

Comprehensive prenatal care has become the hallmark of modern obstetrical practice. Awareness by both physicians and patients that such care is necessary for satisfactory perinatal outcome has led to the establishment of an obstetrical subspecialty, Maternal Fetal Medicine, to provide a higher level of prenatal care and to increase our knowledge of perinatal events. Many of the management techniques currently being used for high-risk pregnancies can be readily applied to the routine obstetrical population. The additional physician time and laboratory tests required are minimal, and the early identification and prevention of perinatal complications will eliminate the need for “crisis” medicine.

Relaxation Of The Supporting Structures Of The Female Pelvis, David H. Nichols

MCV/Q, Medical College of Virginia Quarterly

The purpose of this discussion is to share with you some thoughts about pelvic relaxation, its mysteries, some technical minutiae helpful in identifying them and some of the surgical problems involved. Thus, by looking at a number of these diagnostic challenges, you may be stimulated to some diagnostic thinking in an office setting.

Contraception Versus Sterilization, Thampu Kumarasamy

MCV/Q, Medical College of Virginia Quarterly

The World Health Organization reported that 40% of the pregnancies in the world in 1977 were unplanned and 20% were unwanted; in the United States in 1978 there were 1,300,000 teenage pregnancies, of which one million ended in abortions. To prevent these unwanted pregnancies and also to abolish the cost in terms of money, time and lives, conception control is very important. Contraception is as old as the human race. In ancient times Chinese women swallowed live tadpoles three days after their menses for this purpose. North African women mixed gunpowder solution and foam from a camel’s mouth and drank …