Medicine and Health Sciences Commons^™

Virginia Dental Journal (Vol. 70, No. 3, 1993)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 70, No. 2, 1993)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 70, No. 4, 1993)

Virginia Dental Journal

No abstract provided.

Relationships Among The Distribution Of Terminal Fields Of Sensory Afferent Projections To The Deep Layers Of The Superior Colliculus Within The Cat, Wayne Thomas Shaia

Theses and Dissertations

While it is well known that the different sensory modalities are primarily represented at separate locations within the central nervous system, there are numerous sites in which information from the different sensory modalities converge. Perhaps the best known structure where inputs from different sensory modalities converge is the superior colliculus. Here, not only are visual, auditory and somatosensory inputs present, but they also form organized representations of auditory and visual space as well a map of the body surface in addition, neurons that receive inputs from more than one sensory modality (i.e. multisensory) are found here in abundance. Although a …

Subjectivity Of Estimating Blood Loss Among Health Care Providers In The Operating Room, Hugh Andrew Siegel

Theses and Dissertations

This research utilized a descriptive study to establish a relationship between educational background and accuracy of estimating blood loss. The null hypothesis, that the educational background of health care providers in the operating room has no effect on the accuracy of estimating blood loss , was tested. Ten nurse anesthesia students, 8 certified registered nurse anesthetists, 16 operating room registered nurses, 12 anesthesiologists, and 9 surgeons were included in the sample population. A number of different protocols were utilized to assess the relative accuracy of blood volumes estimates. The study was separated into four stations. Station 1 consisted of three …

Comparison Of Succinylcholine Induced Fasciculation Attenuation With Defasciculating Doses Of Vecuronium And Mivacurium Based On Ideal Body Weight, Marvin E. Early

Theses and Dissertations

This study was conducted to determine if Mivacurium (Miv) was as effective as Vecuronium (Vec) in attenuating Succinylcholine (Sch)-induced fasciculations with muscle relaxant doses based upon ideal body weight (IBW). A quasi experimental design was used to study 60 patients who were randomly assigned to one of three groups. The two study groups were compared to a control group and each other with regards to the incidence and intensity of fasciculations. Either Vec (0.01 mg/kg (IBW)), Miv (0.02 mg/kg (IBW)), or saline (control) was administered in a double-blinded manner 3 minutes prior an intubating dose of Sch (IBW). Both pretreatment …

Safety And Pharmacokinetics Of Multiple Doses Of Intravenous Ofloxacin In Healthy Volunteers, David R. P. Guay, John A. Opsahl, F. Gilbert Mcmahon, Ramon Vargas, Gary R. Matzke, Soledad Flor

Pharmacotherapy and Outcomes Science Publications

The safety and pharmacokinetics of ofloxacin in 48 healthy male volunteers were studied in a two-center, randomized, double-blind, placebo-controlled study. Ofloxacin (200 or 400 mg) or placebo was administered as 1-h infusions every 12 h for 7 days. Plasma ofloxacin concentrations were measured by high-performance liquid chromatography. Mean harmonic half-lives ranged from 4.28 to 4.98 h in the 200-mg dosing group and from 5.06 to 6.67 h in the 400-mg dosing group. Intragroup comparisons of trough plasma concentration-versus-time data from study days 2 through 7 revealed that steady state was achieved by day 2 of both multiple-dose regimens. Intergroup comparisons …

A Comparison Of Standard-Dose And High-Dose Epinephrine In Cardiac Arrest Outside The Hospital, Charles G. Brown, Daniel R. Martin, Paul E. Pepe, Harlan Stueven, Richard O. Commins, Edgar Gonzalez, Michael Jastremski, The Multicenter High-Dose Epinephrine Study Group

Emergency Medicine Publications

BACKGROUND.

Experimental and uncontrolled clinical evidence suggests that intravenous epinephrine in doses higher than currently recommended may improve outcome after cardiac arrest. We conducted a prospective, multicenter study comparing standard-dose epinephrine with high-dose epinephrine in the management of cardiac arrest outside the hospital.

METHODS.

Adult patients were enrolled in the study if they remained in ventricular fibrillation, or if they had asystole or electromechanical dissociation, at the time the first drug was to be administered to treat the cardiac arrest. Patients were randomly assigned to receive either 0.02 mg of epinephrine per kilogram of body weight (standard-dose group, 632 patients) …

Elder-Caregiving Among University Employees: Responsibilities And Needs, Constance L. Coogle, Edward F. Ansello

Virginia Center on Aging Publications

Although many institutions of higher education often house the researchers who study eldercare, few have documented the need for information and services among their estimated 460,000 employees who face the difficult task of effectively balancing work and eldercare responsibilities. Even fewer have established programs to address this need.

Drs. Constance Coogle and Edward Ansello have recently completed an exhaustive survey of VCU employees (N = 11,430) to determine the extent to which they provide care to disabled parents or spouses.[1] A longer, more detailed survey was sent to those who indicated that they were eldercaregivers to measure their perceived …

Transmission Of Human Immunodeficiency Virus Type 1 From A Seronegative Organ And Tissue Donor, R.J. Simonds , M.D., Scott D. Holmberg M.D., M.P.H., Richard L. Hurwitz , M.D., Theresa R. Coleman , B.A., Scott Bottenfield , R.N., Lois J. Conley , M.T., M.P.H., Sherry H. Kohlenberg , M.H.A., Kenneth G. Castro , M.D., Beverley A. Dahan , B.A., Charles A. Schable , M.S., Mark A. Rayfield , Ph.D., Martha F. Rogers , M.D.

Health Administration Publications

Abstract

BACKGROUND

Since 1985, donors of organs or tissues for transplantation in the United States have been screened for human immunodeficiency virus type 1 (HIV-1), and more than 60,000 organs and 1 million tissues have been transplanted. We describe a case of transmission of HIV-1 by transplantation of organs and tissues procured between the time the donor became infected and the appearance of antibodies. The donor was a 22-year-old man who died 32 hours after a gunshot wound; he had no known risk factors for HIV-1 infection and was seronegative.

METHODS

We reviewed the processing and distribution of all the …

Virginia Dental Journal (Vol. 69, No. 3, 1992)

Virginia Dental Journal

No abstract provided.

Sequence Specificity Of Teniposide-Induced Deletion And Insertion Mutations At The Aprt Locus Of Chinese Hamster Cells, Yi-Hong Han

Theses and Dissertations

Previous studies suggested that teniposide is a strong clastogen, and that the DNA breakage effect of this drug is mediated by the nuclear enzyme topoisomerase II. Ripley et al found evidence for a correspondence between sites of acridine-induced frameshift mutations in bacteriophage T4 and sites of in Vitro DNA cleavage by T4 topoisomerase II. To identify the sequence specificity of teniposide-induced deletion and insertion mutations in mammalian cells, the CHO-D422 cell line, which is hemizygous at the aprt locus, was employed in this study. Sixty-eight teniposide-induced and 42 spontaneous aprt mutants were analyzed at the DNA sequence level. Compared with …

The Effect Of Body Position Changes On Arterial Oxygen Saturation In Obesity As Measured Noninvasively By Pulse Oximetry, Anna Marie Angela Klosterman

Theses and Dissertations

This study utilized a quasi-experimental pretest-posttest design that compared the effect of body position changes on arterial oxygen saturation in obesity as measured noninvasively by pulse oximetry. The null hypothesis, that there would be no difference between oxygen saturation values measured by pulse oximetry with position change from sitting to supine in obese subjects as compared to nonobese subjects, was tested. Fourteen obese, American Society of Anesthesiologist (ASA) physical class status II subjects and 14 nonobese ASA physical class status I subjects were included in the sample population. Thirteen of the obese subjects were further classified as morbidly obese. After …

Evaluation Of Quantitative Electroencephalography For Assessment Of Central Nervous System Stimulant Response, Patricia W. Slattum

Theses and Dissertations

The objective of this investigation was to evaluate quantitative electroencephalography (EEG) as a measure of CNS stimulation. The reproducibility and sensitivity of quantitative EEG was compared to neuroendocrine, mood, and psychomotor performance measures.

The study was conducted in two parts. The first part investigated the inter- and intra-individual variability associated with a series of pharmacological response measures under baseline (no drug) conditions. It was an open-label pilot study in which eight healthy male volunteers underwent a series of tests (EEG, visual continuous performance task (CPT), a finger tapping task, and self-rated mood scales) repeated eight times over a 12 hour …

An Analysis Of The Values Influencing Neonatal Nurses' Perceptions And Behaviors In Selected Ethical Dilemmas, Deborah A. Raines

Theses and Dissertations

The purpose of this research was to identify the values influencing the nurse's perception and choice of behavior in a hypothetical clinical situation. The theoretical framework was Rokeach's (1973) Theory on the Nature of Human Values and Value Systems. A descriptive study using a mailed survey was conducted on a random sample of 331 members of the National Association of Neonatal Nurses. Data on individual nurses' values, perception of information and behavioral choices were collected with an investigator developed questionnaire, consisting of a values scale (alpha =.82) and an information scale and choice alternatives related to three hypothetical vignettes: a …

Virginia Dental Journal (Vol. 69, No. 2, 1992)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 69, No. 4, 1992)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 69, No. 1, 1992)

Virginia Dental Journal

No abstract provided.

The Effect Of Tourniquet Application On Systemic Coagulation, Christa Choate Hudalla

Theses and Dissertations

Seven orthopedic surgery patients requiring the use of a tourniquet were studied. The hypothesis stated that tourniquet application does not affect coagulation. A total of 5 blood samples were drawn perioperatively (preoperative, 5 minutes after induction of anesthesia, 30 minutes after tourniquet inflation, 2 - 5 minutes after tourniquet deflation, and 30 minutes after tourniquet deflation. For each sample, TEG parameters (R, R + k, MA and α) were measured.

The value for each TEG parameter was compared by analysis of variance (ANOVA), then the samples were contrasted and examined by repeated measures ANOVA. None of the TEG parameters showed …

Regulation Of Phosphatidylinositol 4-Kinase Activity In Rat Pancreatic Acini, Bruce R. Conway

Theses and Dissertations

The present report describes the characteristics and regulatory properties of phosphatidylinositol (Ptdlns) 4-kinase activity in rat exocrine pancreas. The membrane associated Ptdlns 4-kinase displayed a broad pH profile with optimal activity at neutral to alkaline pH. Carbachol (CCh) elicits a concentration- and time-dependent increase in Ptdlns 4-kinase activity in homogenates derived from agonist-stimulated acini. This effect was blocked by N-methylscopolamine and mimicked by muscarine. The enzyme had an apparent Km for Ptdlns and ATP of 4 and 60 uM, respectively. CCh caused no discernible change in the Km for either Ptdlns or ATP, but did produce a modest increase in …

A Proud Heritage : 100 Years Of Nursing Education, Virginia Commonwealth University

VCU University History Books

In the late 1980s, nursing alumni, faculty, and students began planning for the one hundredth anniversary observance of the founding of the Virginia Commonwealth University School of Nursing. The school traces its rich heritage back to the organization of the Virginia Hospital Training School for Nurses which opened in 1893. Betsy A. Bampton (MCV Class of 1960) undertook the writing of a school history published as the centennial celebration was set to begin. In this abundantly illustrated work, Bampton and her collaborators chronicle the development and growth of the eight diverse schools and programs that formed the foundation of the …

Oculomotor Deficits In Diseases Of The Basal Ganglia: Parkinson's And Huntington's Diseases, Todd B. Baird

Theses and Dissertations

Oculomotor deficits are now recognized as being present in several neurological diseases of the basal ganglia. The present report will focus primarily on those observed in Huntington's and Parkinson's diseases. Neuronal cell loss in the pars compacta of the substantia nigra, degeneration of the nigrostriatal pathway, and consequent depletion of the neurotransmitter dopamine is the most obvious etiological abnormality in Parkinson's disease. Huntington's disease, on the other hand, involves the selective genetically-driven atrophy of the striatum (caudate and putamen). In order to attempt to understand oculomotor dysfunction, as a component of basal ganglia disease, it is necessary to first establish …

Efficacy And Cost-Effectiveness Of Adjuvant Chemotherapy In Women With Node-Negative Breast-Cancer - A Decision-Analysis Model, Bruce E. Hillner , M.D., Thimas J. Smith M. D.

Internal Medicine Publications

BACKGROUND.

In 1988 the National Cancer Institute issued a Clinical Alert that has been widely interpreted as recommending that all women with node-negative breast cancer receive adjuvant chemotherapy. Acceptance of this recommendation is controversial, since many women who would not have a recurrence would be treated.

METHODS.

Using a decision-analysis model, we studied the cost effectiveness of chemotherapy in cohorts of 45-year-old and 60-year-old women with node-negative breast cancer by calculating life expectancy as adjusted for quality of life. The analysis evaluated different scenarios of the benefit of therapy: improved disease-free survival for five years, with a lesser effect on …

Pharmacokinetics Of Ceftibuten-Cis And Its Trans Metabolite In Healthy Volunteers And In Patients With Chronic Renal Insufficiency, Judy Shepard Kelloway, Walid M. Awni, Chin C. Lin, Josephine Lim, Melton B. Affrime, William F. Keane, Gary R. Matzke, Charles E. Halstenson

Pharmacotherapy and Outcomes Science Publications

The impact of renal insufficiency on the dispositions of 300 mg of orally administered ceftibuten-cis, a new broad-spectrum oral cephalosporin, and its primary metabolite ceftibuten-trans was characterized in 30 adult subjects. Subjects were divided into five groups of six subjects each on the basis of their 24-h ambulatory creatinine clearances (CL_CR). The apparent total body clearance (CL_P/F; where F is absolute bioavailability) and renal clearance of ceftibuten-cis were significantly lower in subjects with end-stage renal disease (on maintenance hemodialysis; group V) and in those with severe (CL_CR, 5 …

Virginia Dental Journal (Vol. 68, No. 2, 1991)

Virginia Dental Journal

No abstract provided.

Efficacy And Cost Effectiveness Of Adjuvant Chemotherapy In Women With Node-Negative Breast Cancer — A Decision-Analysis Model, Bruce E. Hillner , M.D., Thomas J. Smith , M.D.

Massey Comprehensive Cancer Center Publications

Abstract

BACKGROUND.

In 1988 the National Cancer Institute issued a Clinical Alert that has been widely interpreted as recommending that all women with node-negative breast cancer receive adjuvant chemotherapy. Acceptance of this recommendation is controversial, since many women who would not have a recurrence would be treated.

METHODS.

Using a decision-analysis model, we studied the cost effectiveness of chemotherapy in cohorts of 45-year-old and 60-year-old women with node-negative breast cancer by calculating life expectancy as adjusted for quality of life. The analysis evaluated different scenarios of the benefit of therapy: improved disease-free survival for five years, with a lesser effect …

Virginia Dental Journal (Vol. 68, No. 1, 1991)

Virginia Dental Journal

No abstract provided.

Geriatic Nurse Practitioner's Health Promotive Behaviors: A Test Of Theory Of Reasoned Action, Sandra L. Venegoni

Theses and Dissertations

The purpose of this investigation was to develop an instrument to test the theory of reasoned action (Fishbein & Ajzen, 1975) in a new behavioral domain the health promotive behaviors of geriatric nurse practitioners (GNPs). The two behavioral categories included in the study were health assessment and health teaching, each with its individual index of actions.

A questionnaire was developed to examine the beliefs of a sample of 200 certified geriatric nurse practitioners and to test the relationships of the theoretical model. Names of the subjects were randomly selected from the American Nurses' Association 1989 list of certified GNPs. Ninety-four …

Mechanisms Of Regulation Of The Human C-Myb Proto-Oncogene During Myelomonocytic Differentiation, Lawrence H. Boise

Theses and Dissertations

Control of hematopoiesis is a complex set of events that is currently being dissected at the molecular level. To determine factors that may be crucial for commitment to terminal differentiation of myelomonocytic cells, a mutant of the HL-60 cell line was characterized at the cellular and molecular level. This clone, termed DMSOr, was shown to differentiate in a similar fashion as parental HL-60 in response to 1.3% DMSO at the morphologic and functional level. The anti-proliferative aspects of differentiation were also present in DMSOr as evidenced by decreased 3H-thymidine incorporation and an increased percentage of cells in the G0/G1 phase …

Virginia Dental Journal (Vol. 68, No. 3, 1991)

Virginia Dental Journal

No abstract provided.