Medicine and Health Sciences Commons^™

Β Cell Network Dysfunction In Pancreatic Islets By Silencing Hub Cells, Janita Patwardhan, Bradford E. Peercy

Biology and Medicine Through Mathematics Conference

No abstract provided.

Coupled Influence Of Heart Rate Variability And Subcellular Calcium Heterogeneity On Cardiac Electromechanical Dynamics, Vrishti M. Phadumdeo, Seth H. Weinberg Ph.D

Biology and Medicine Through Mathematics Conference

No abstract provided.

Development Of A Mathematical Model For The Role Of Inflammation In Atherosclerosis, Marcella Torres, Jing Wang, Paul J. Yannie, Shobha Ghosh, Rebecca Segal, Angela Reynolds

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Pharmacokinetic Model Of Lead Absorption And Calcium Competitive Dynamics, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Robust Estimation For Factor Loadings With Application To Postpartum Depression, Kenneth Nieser

Biology and Medicine Through Mathematics Conference

No abstract provided.

Immunofluorescence Image Feature Analysis And Clustering Pipeline For Distinguishing Epithelial-Mesenchymal Transition, Shreyas Hirway, Nadiah Hassan, Dr. Christopher Lemmon, Dr. Seth Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.

Understanding Toxin Production During Clostridioides Difficile Infection Using High Dimensional Data, Samantha Erwin, Joshua R. Fletcher, Casey M. Theriot, Cristina Lanzas

Biology and Medicine Through Mathematics Conference

No abstract provided.

Non-Mechanistic Learning Of Pdes From Discrete Spatial Data In Biology, Gary M. Lavigne Jr

Biology and Medicine Through Mathematics Conference

No abstract provided.

Decoys And Dilution: The Impact Of Incompetent Hosts On Prevalence Of Chagas Disease, Mondal H. Zahid

Biology and Medicine Through Mathematics Conference

No abstract provided.

Parameter Identifiability Of A Dynamical System Model Of Breathing In A Preterm Infant, Laura Ellwein Fix, Henry Rozycki

Biology and Medicine Through Mathematics Conference

No abstract provided.

Real-Time Interactive Simulation Of Human Atrial Electrical Activity On Realistic 3d Atrial Structures Using Webgl, Abouzar Kaboudian, Yanyan Ji, Elizabeth Cherry, Flavio H. Fenton

Biology and Medicine Through Mathematics Conference

No abstract provided.

Plenary Talk: Data Assimilation With Applications To Neuroscience, Tim Sauer

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Model Of Online Latent State Learning, Amy Cochran

Biology and Medicine Through Mathematics Conference

No abstract provided.

Machine Learning Methods To Forecast Temporal Pattern Of Aedes Mosquito Species Using Meteorological Variables In Ontario, Canada, Mohammad A. Al-Mamun, Ernest O. Asare

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Malaria Dynamics With The Inclusion Of Long And Short Incubation Periods, Ana L. Vivas-Barber, Anne M. Fernando, Sunmi Lee

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Malaria-Hiv/Aids Co-Infection Model With Optimal Treatment And Insecticide-Treated Bednets, Eric Numfor

Biology and Medicine Through Mathematics Conference

No abstract provided.

Plenary Talk: Modeling The Folding Patterns Of The Human Brain In Development, Health, And Disease, Monica Hurdal

Biology and Medicine Through Mathematics Conference

No abstract provided.

A State-Level Study Of Opioid Use Disorder Treatment Access And Neonatal Abstinence Syndrome, Elizabeth R. Wolf, Sebastian T. Tong, Roy T. Sabo, Steven H. Woolf, Kassie Abbinanti, James Pecsok, Alex H. Krist

Pediatrics Publications

Background Adult opioid use and neonatal abstinence syndrome (NAS) are growing public health problems in the United States (U.S.). Our objective was to determine how opioid use disorder treatment access impacts the relationship between adult opioid use and NAS.

Methods We conducted a cross-sectional state-level ecologic study using 36 states with available Healthcare Cost and Utilization Project State Inpatient Databases in 2014. Opioid use disorder treatment access was determined by the: 1) proportion of people needing but not receiving substance use treatment, 2) density of buprenorphine-waivered physicians, and 3) proportion of individuals in outpatient treatment programs (OTPs). The incidence of …

Providers’ Perception Of Alert Fatigue After Implementation Of User-Filtered Warnings, Hina Afaq, Sahaana Mukundan, Sadaf Zia, Alisa K. Escano Dr., Rebecca Lear Dr., Casey Washington Dr.

Pharmacotherapy and Outcomes Science Publications

Alert fatigue is a complex problem that many health institutions face when using an electronic health record (EHR). The addition of user-filtered warnings (UFW) is a physicians’ proposed intervention at Inova Health System (IHS), a large 5-hospital health system in Northern Virginia, that allows prescribers to filter out specific drug-drug interactions and pregnancy and lactation medication alerts for a 30-day period. This study aims to determine the impact of UFW on physicians’ perception of alert fatigue and to calculate the reduction of medication alerts. It was hypothesized that the reduction in alerts will significantly impact physicians’ perception of alert fatigue …

A Systematic Review Of Cases Of Meningitis In The Absence Of Cerebrospinal Fluid Pleocytosis On Lumbar Puncture, Michelle Troendle, Alexis Pettigrew

Emergency Medicine Publications

Background: Definitive diagnosis of meningitis is made by analysis of cerebrospinal fluid (CSF) culture or polymerase chain reaction (PCR) obtained from a lumbar puncture (LP), which may take days. A timelier diagnostic clue of meningitis is pleocytosis on CSF analysis. However, meningitis may occur in the absence of pleocytosis on CSF.

Areas of Uncertainty: A diagnosis of meningitis seems less likely without pleocytosis on CSF, leading clinicians to prematurely exclude this. Further, there is little available literature on the subject.

Methods: Ovid/Medline and Google Scholar search was conducted for cases of CSF culture-confirmed meningitis with lack of pleocytosis. …

Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities In A Dfp-Based Rat Model Of Gulf War Illness, Laxmikant Deshpande, Edna Santos, Kristin Phillips, Robert Blair

Neurology Publications

Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of the First Gulf War, and includes neurological symptoms characterized by depression and memory deficits. Chronic exposure to organophosphates (OP) is considered a leading cause for GWI, yet its pathobiology is not fully understood. We recently observed chronic elevations in neuronal Ca2+ levels ([Ca2+]i) in an OP- diisopropyl fluorophosphate (DFP) based rat model for GWI. This study was aimed at identifying mechanisms underlying elevated [Ca2+]i in this DFP model and investigating whether their therapeutic targeting could improve GWI-like neurological morbidities. Male Sprague-Dawley rats (9-wks) were exposed to DFP …

A Competency-Based Approach To Faculty Development, Betsy Ripley Md, Jean Bailey Phd, Kenneth Warren Edd, Katherine J T Henderson Med

Publications from the Office of the Dean

Background—Faculty development at the Virginia Commonwealth University School of Medicine (VCU SOM) has previously focused on enhancing teaching and learning in the medical and clinical education settings. While this work is important, this narrow focus does not address all facets a faculty member’s role. To broaden their programming, the VCU SOM faculty development team adopted a competency-based approach to the development and planning of faculty development activities.

Summary of work—The Senior Associate Dean for Faculty Affairs completed a research project focused on successful medical faculty who promote through the tenure process and advance in their careers. She identified …

Electronic Nicotine Delivery Systems: Vaping Away Gum Tissue, Christina Tulloch, Denise Thieleman

Dental Hygiene Student Scholarship

Objective: Conventional cigarettes have shown severe toxicity on immune cells and wound healing in the periodontium, but little is known about the comparative effects of vaping or electronic cigarettes. In a substantial shift away from conventional cigarettes, vaping and e-cigarette sales have increased nearly 600% since 2017. If current conventional cigarette users are to transition to a less detrimental alternative, the evidence must demonstrate if electronic nicotine delivery systems can be deemed safer than conventional options.

Methods: By compiling data from the PubMed database, the most recent perspectives on new smoking methods and effects of usage on periodontal tissues were …

Oil Pulling: Fact Or Fad?, Cassandra N. Cooper

Dental Hygiene Student Scholarship

Problem: There is a greater need in today’s world for better oral care across all populations. In developing countries, the tradition of oil pulling has provided an affordable and accessible alternative to antimicrobial rinse agents. Western society has taken note of this and oil pulling has emerged as the latest oral hygiene fad.

Methods: This review of literature used the following databases: PubMed, CINAHL and Google Scholar to identify relevant research articles. Search terms included oil pulling, coconut oil, sesame seed oil, oil swishing, oral health, periodontitis, gingivitis, and bacterial adherence. The studies reviewed used previously validated data collection methods …

Dental Dam Utilization By Dentists In An Intramural Faculty Practice, Terence A. Imbery, Caroline K. Carrico

General Practice Publications

Objectives: From casual observation of our colleagues, only a few individuals use the dental dam for operative procedures in their faculty practice. The purpose of this study was to obtain faculty perceptions of the dental dam, quantify its utilization in their intramural faculty practice, and determine the factors that influence dental dam usage.


Materials and Methods: A survey containing 11 questions was sent to 19 faculty members who teach full time and maintain an intramural dental practice involving operative dentistry. Thirty electronic dental health records of the 19 providers were reviewed to gather the following information from restorative procedures they …

Use Of Endoloop In Video-Assisted Thoracoscopic Enucleation Of A Very Rare Esophageal Tumor, Yahya Alwatari, Wayne Tse, Kasia Trebska-Mcgowan, Rachit D. Shah

Surgery Publications

A gastrointestinal stromal tumor is an infrequent tumor of the gastrointestinal tract with very rare involvement of the esophagus. We present a case of a patient with dysphagia and a 4 cm submucosal mass. The patient underwent thoracoscopic enucleation with complete resection of the mass. We present case details and operative video highlighting the important surgical steps of exposure and retraction. We believe that the Endoloop is a very useful tool in providing countertraction needed during minimally invasive resection of such lesions.

Association Of Anti-Mullerian Hormone With C-Reactive Protein In Men, Dinesh Kadariya, Nargiza Kurbanova, Rehan Qayyum

Internal Medicine Publications

While serum anti-mullerian hormone (AMH) levels are inversely associated with all-cause mortality in men, the underlying mechanisms are unclear. Elevated levels of inflammation, also associated with all-cause mortality, and may be the link between AMH and mortality. Hence, we examined the association of AMH with serum c-reactive protein (CRP), a biomarker of inflammation, in men. We included men ≥20 years from the National Health and Nutrition Examination Survey (1999–2004). We used survey weight-adjusted linear regression to examine the association between AMH and CRP without and with adjustment for age, race, body mass index (BMI), smoking, hypertension, diabetes, cholesterol, glomerular filtration …

Unsaturated Fatty Acids To Improve Cardiorespiratory Fitness In Patients With Obesity And Hfpef, Salvatore Carbone, Hayley E. Billingsley, Justin M. Canada, Dinesh Kadariya, Horacio Medina De Chazal, Brando Rotelli, Nicola Potere, Bishal Paudel, Roshi Markley, Dave L. Dixon, Cory R. Trankle, Benjamin W. Van Tassell, Francesco S. Celi, Antonio Abbate

Internal Medicine Publications

No abstract provided.

The Association Between Urinary Genistein Levels And Mortality Among Adults In The United States, Carolyn Marcelo, Melissa Warwick, Catherine Marcelo, Rehan Qayyum

Internal Medicine Publications

Background
Current research on the relationship between phytoestrogens and mortality has been inconclusive. We explored the relationship between genistein, a phytoestrogen, and mortality in a large cohort representative of the United States population.


Methods: Data were analyzed from the National Health and Nutrition Examination Survey (NHANES) from 1999–2010. Normalized urinary genistein (nUG) was analyzed as a log-transformed continuous variable and in quartiles. Mortality data were obtained from the National Death Index and matched to the NHANES participants. Survival analyses were conducted using the Kaplan-Meier analysis. Cox proportional hazard models were constructed for all-cause and cause-specific mortality without and with …

Remote Ischemic Pre-Conditioning Attenuates Adverse Cardiac Remodeling And Mortality Following Doxorubicin Administration In Mice, Zachary M. Gertz, Chad Cain, Donatas Kraskauskas, Teja Devarakonda, Adolfo G. Mauro, Jeremy Thompson, Arun Samidurai, Qun Chen, Sarah W. Gordon, Edward J. Lesnefsky, Anindita Das, Fadi N. Salloum

Internal Medicine Publications

Objectives

Because of its multifaceted cardioprotective effects, remote ischemic pre-conditioning (RIPC) was examined as a strategy to attenuate doxorubicin (DOX) cardiotoxicity.

Background

The use of DOX is limited by dose-dependent cardiotoxicity and heart failure. Oxidative stress, mitochondrial dysfunction, inflammation, and autophagy modulation have been proposed as mediators of DOX cardiotoxicity.

Methods

After baseline echocardiography, adult male CD1 mice were randomized to either sham or RIPC protocol (3 cycles of 5 min femoral artery occlusion followed by 5 min reperfusion) 1 h before receiving DOX (20 mg/kg, intraperitoneal). The mice were observed primarily for survival over 85 days (86 mice). An …