Medicine and Health Sciences Commons^™

Pnpla3 Polymorphisms And Liver Aminotransferase Levels In A Mexican American Population, Quan Li, Hui-Qi Qu, Anne R. Rentfro, Megan L. Grove, S. Mirza, Yang Lu, Craig Hanis, Michael B. Fallon, Eric Boerwinkle, Susan P. Fisher-Hoch, Joseph B. Mccormick

School of Nursing Faculty Publications

Purpose: This study examined genetic associations of patatin-like phospholipase domain containing 3 gene (PNPLA3) polymorphisms and liver aminotransferases in an extensively documented, randomly recruited Mexican American population at high risk of liver disease.

Methods: Two single nucleotide polymorphisms (SNP) in the PNPLA3 gene (i.e., rs738409 and rs2281135) were genotyped in 1532 individuals. Population stratification was corrected by the genotyping of 103 ancestry informative markers (AIMs) for Mexican Americans.

Results: Both PNPLA3 SNPs showed highly significant association with alanine aminotransferase (ALT) levels, but was also, in males, associated with aspartate aminotransferase (AST) levels. Haplotypic association test of the two SNPs suggested …

Population-Based Risk Factors For Elevated Alanine Aminotransferase In A South Texas Mexican-American Population, Hui-Qi Qu, Quan Li, Megan L. Grove, Yang Lu, Jen-Jung Pan, Anne R. Rentfro, Perry E. Bickel, Michael B. Fallon, Craig L. Hanis, Eric Boerwinkle, Joseph B. Mccormick, Susan P. Fisher-Hoch

School of Nursing Faculty Publications

Background and aims: Elevated alanine aminotransferase (ALT >40 IU/mL) is a marker of liver injury but provides little insight into etiology. We aimed to identify and stratify risk factors associated with elevated ALT in a randomly selected population with a high prevalence of elevated ALT (39%), obesity (49%) and diabetes (30%).

Methods: Two machine learning methods, the support vector machine (SVM) and Bayesian logistic regression (BLR), were used to capture risk factors in a community cohort of 1532 adults from the Cameron County Hispanic Cohort (CCHC). A total of 28 predictor variables were used in the prediction models. The recently …

Machine Learning Approach To Extract Diagnostic And Prognostic Thresholds: Application In Prognosis Of Cardiovascular Mortality, Luis J. Mena, Eber E. Orozco, Vanessa G. Felix, Rodolfo Ostos, Jesus D. Melgarejo, Gladys E. Maestre

School of Medicine Publications

Machine learning has become a powerful tool for analysing medical domains, assessing the importance of clinical parameters, and extracting medical knowledge for outcomes research. In this paper, we present a machine learning method for extracting diagnostic and prognostic thresholds, based on a symbolic classification algorithm called REMED. We evaluated the performance of our method by determining new prognostic thresholds for well-known and potential cardiovascular risk factors that are used to support medical decisions in the prognosis of fatal cardiovascular diseases. Our approach predicted 36% of cardiovascular deaths with 80% specificity and 75% general accuracy. The new method provides an innovative …

Missed Opportunities For Diagnosis And Treatment Of Diabetes, Hypertension, And Hypercholesterolemia In A Mexican American Population, Cameron County Hispanic Cohort, 2003-2008, Susan P. Fisher-Hoch, Kristina Vatcheva, Susan T. Laing, Monir Hossain, M Hossein Rahbar, Craig Hanis, H Shelton Brown, Anne R. Rentfro, Belinda M. Reininger, Joseph B. Mccormick

School of Mathematical & Statistical Sciences Faculty Publications

Introduction

Diabetes, hypertension, and hypercholesterolemia are common chronic diseases among Hispanics, a group projected to comprise 30% of the US population by 2050. Mexican Americans are the largest ethnically distinct subgroup among Hispanics. We assessed the prevalence of and risk factors for undiagnosed and untreated diabetes, hypertension, and hypercholesterolemia among Mexican Americans in Cameron County, Texas.

Methods

We analyzed cross-sectional baseline data collected from 2003 to 2008 in the Cameron County Hispanic Cohort, a randomly selected, community-recruited cohort of 2,000 Mexican American adults aged 18 or older, to assess prevalence of diabetes, hypertension, and hypercholesterolemia; to assess the extent to …

Measuring And Comparing Brain Cortical Surface Area And Other Areal Quantities, Anderson M. Winkler, Mert R. Sabuncu, B T. Yeo, Bruce Fischl, Douglas N. Greve, Peter Kochunov, Thomas E. Nichols, John Blangero, David C. Glahn

School of Medicine Publications

Structural analysis of MRI data on the cortical surface usually focuses on cortical thickness. Cortical surface area, when considered, has been measured only over gross regions or approached indirectly via comparisons with a standard brain. Here we demonstrate that direct measurement and comparison of the surface area of the cerebral cortex at a fine scale is possible using mass conservative interpolation methods. We present a framework for analyses of the cortical surface area, as well as for any other measurement distributed across the cortex that is areal by nature. The method consists of the construction of a mesh representation of …

Association Of A Serotonin Transporter Gene (Slc6a4) 5-Httlpr Polymorphism With Body Mass Index Categories But Not Type 2 Diabetes Mellitus In Mexicans, Valeria Peralta-Leal, Evelia Leal-Ugarte, Juan P. Meza-Espinoza, Ingrid P. Dávalos-Rodríguez, Anabel Bocanegra-Alonso, Rosa I. Acosta-González, Enrique Gonzales, Saraswathy Nair, Jorge Durán-González

Health & Biomedical Sciences Faculty Publications

The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy-Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development …

Identifying Risk Factors For Disparities In Breast Cancer Mortality Among African-American And Hispanic Women, Nancy Tian, Pierre Goovaerts, T. Benjamin Zhan, T. Edwin Chow, J. Gaines Wilson

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Background: This study evaluated the risk factors associated with racial disparities in female breast cancer mortality for African-American and Hispanic women at the census tract level in Texas from 1995 to 2005.

Methods: Data on female breast cancer cases were obtained from the Texas Cancer Registry. Socioeconomic and demographic data were collected from Census 2000. Network distance and driving times to mammography facilities were estimated using Geographic Information System techniques. Demographic, poverty and spatial accessibility factors were constructed using principal component analysis. Logistic regression models were developed to predict the census tracts with significant racial disparities in breast cancer mortality …

Application Of A Novel Method For Assessing Cumulative Risk Burden By County, Jennifer J. Salinas, Manasi Shah, Bassent Abdelbary, Jennifer L. Gay, Ken Sexton

Physician Assistant Studies Faculty Publications

The purpose of this study is to apply the Human Security Index (HSI) as a tool to detect social and economic cumulative risk burden at a county-level in the state of Texas. The HSI is an index comprising a network of three sub-components or “fabrics”; the Economic, Environmental, and Social Fabrics. We hypothesized that the HSI will be a useful instrument for identifying and analyzing socioeconomic conditions that contribute to cumulative risk burden in vulnerable counties. We expected to identify statistical associations between cumulative risk burden and (a) ethnic concentration and (b) geographic proximity to the Texas-Mexico border. Findings from …

Using The Framingham Risk Score To Evaluate Immigrant Effect On Cardiovascular Disease Risk In Mexican Americans, Jennifer J. Salinas, Bassent Abdelbary, Jeffrey Wilson, Monir Hossain, Susan P. Fisher-Hoch, Joseph B. Mccormick

Physician Assistant Studies Faculty Publications

Background—This study uses the Framingham Risk Score (FRS) for 10-year cardiovascular disease (CVD) to evaluate differences between Mexican American immigrants and the U.S.-born population. Methods and Results—Data from the Cameron County Hispanic Cohort (N=1,559). Average total risk scores were generated by age group for each gender. Regression analysis was conducted adjusting for covariates and interaction effects. Both women and men in the CCHC sample who were long-term immigrant residents (mean FRS scores women 4.2 with p<.001 vs. men 4.0 with p<.001) or born in the U.S. (mean FRS scores women 4.6 with p<.001 vs. men 3.3 with p<.001) had significantly higher risk scores than immigrants who had only been in this country for less than 10 years. The interaction model indicates that differences between immigrant and native-born Mexican Americans are most greatly felt at lowest levels of socioeconomic status for men in the CCHC. Conclusions—This study suggests that in terms of immigrant advantage in CVD risk, on whom, where, and how the comparisons are being made have important implications for the degree of difference observed.

Border Hispanics’ Physical Activity Improvement In A Chronic Disease Prevention Program, Lu Xu

Theses and Dissertations - UTB/UTPA

In seeking of effective prevention programs to improve physical activities, we want to examine the factors related to physical activities improvement in Alliance for a Healthy Border, a chronic disease prevention program with pre-post-post evaluations through 12 federally qualified community health centers serving primarily Hispanics in communities along the U.S.- Mexico border. Logistic regression was performed to examine the association between physical activity and twenty predictors at baseline. Multinomial regression was used to examine the determinants of physical activities improvement at two time points: program end and post six-months. Socio-demographic, baseline health condition factors, and determination of doing physical activity …

Identification Of Common Variants Associated With Human Hippocampal And Intracranial Volumes, Jason L. Stein, Anderson M. Winkler, Laura Almasy, Joanne E. Curran, Marcio Almeida, Ravi Duggirala, Thomas D. Dyer, Harald H. H. Goring, Matthew P. Johnson, John Blangero

School of Medicine Publications

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 …

Electrocardiographic Abnormalities Among Mexican Americans: Correlations With Diabetes, Obesity, And The Metabolic Syndrome, Saulette R. Queen, Beverly Smulevitz, Anne R. Rentfro, Kristina Vatcheva, David D. Mcpherson, Susan P. Fisher-Hoch, Joseph B. Mccormick, Susan T. Laing

School of Mathematical & Statistical Sciences Faculty Publications

Background: Resting ischemic electrocardiographic abnormalities have been associated with cardiovascular mortality. Simple markers of abnormal autonomic tone have also been associated with diabetes, obesity, and the metabolic syndrome in some populations. Data on these electrocardiographic abnormalities and correlations with coronary risk factors are lacking among Mexican Americans wherein these conditions are prevalent.

Objective: This study aimed to evaluate the prevalent resting electrocardiographic abnormalities among community-dwelling Mexican Americans, and correlate these findings with coronary risk factors, particularly diabetes, obesity, and the metabolic syndrome.

Methods: Study subjects (n=1280) were drawn from the Cameron County Hispanic Cohort comprised of community-dwelling Mexican Americans living …

Cranial Electrotherapy Stimulation In The Treatment Of Posttraumatic Stress Disorder: A Pilot Study Of Two Military Veterans, Alfred G. Bracciano, Wen-Pin Chang, Stephanie Kokesh, Abe Martinez, Melissa Meier, Kathleen Moore

Occupational Therapy Faculty Publications

This case study investigated the effects of cranial electrotherapy stimulation (CES) on the prevalence and intensity of posttraumatic stress disorder (PTSD) symptoms and self- perceived improvement of performance and satisfaction in daily activities in war veterans. Two male Caucasian veterans (ages 54 and 38) diagnosed with PTSD participated in these case studies with a pretest–posttest design. The Canadian Occupational Performance Measure (COPM) and the PTSD Symptom Scale–Interview (PSS-I) were administered before and after the 4-week CES treatment. The participants self-administered the 4-week CES treatment protocol using Alpha-Stim SCS CES device in their home for 20 to 60 min a day, …

Host Susceptibility To Tuberculosis: Insights From A Longitudinal Study Of Gene Expression In Diabetes, Hui-Qi Qu, Anne R. Rentfro, Yang Lu, Saraswathy Nair, Craig Hanis, Joseph B. Mccormick, Susan P. Fisher-Hoch

Health & Biomedical Sciences Faculty Publications

Tuberculosis (TB) remains a major global disease, and diabetes which is documented to increase susceptibility to TB threefold, is also becoming pandemic. This susceptibility has been attracting extensive research interest. The increased risk of TB in diabetes may serve as a unique model to understand host susceptibility to specific pathogens in humans. To examine this rationale, we investigated expression of reported TB candidate genes in a longitudinal diabetes study. Two genes HK2 and CD28 emerged as potential culprits in diabetes-increased TB susceptibility.

Air Pollution And Acute Respiratory Response In A Panel Of Asthmatic Children Along The U.S.–Mexico Border, Stefanie E. Sarnat, Amit U. Raysoni, Wen-Whai Li, Fernando Holguin, Brent A. Johnson, Silvia Flores Luevano, Jose Humberto Garcia, Jeremy A. Sarnat

School of Earth, Environmental, & Marine Sciences Faculty Publications

Background: Concerns regarding the health impact of urban air pollution on asthmatic children are pronounced along the U.S.–Mexico border because of rapid population growth near busy border highways and roads.

Objectives: We conducted the first binational study of the impacts of air pollution on asthmatic children in Ciudad Juarez, Mexico, and El Paso, Texas, USA, and compared different exposure metrics to assess acute respiratory response.

Methods: We recruited 58 asthmatic children from two schools in Ciudad Juarez and two schools in El Paso. A marker of airway inflammation [exhaled nitric oxide (eNO)], respiratory symptom surveys, and pollutant measurements (indoor and …

Biocompatible Gold Nanorod Conjugates For Preclinical Biomedical Research, Anton Liopo, André Conjusteau, Dmitri Tsyboulski, Boris Ermolinsky, Alexander V. Kazanksy, Alexander Oraevsky

Health & Biomedical Sciences Faculty Publications

Gold nanorods with a peak absorption wavelength of 760 nm were prepared using a seed-mediated method. A novel protocol has been developed to replace hexadecyltrimethylammonium bromide on the surface of the nanorods with 16-mercaptohexadecanoic acid and metoxy-poly(ethylene glycol)-thiol, and the monoclonal antibody HER2. The physical chemistry properties of the conjugates were monitored through optical and zeta-potential measurements to confirm surface chemistry changes. The efficiency of the modifications was quantified through measurement of the average number of antibodies per gold nanorod. The conjugates were investigated for different cells lines: BT-474, MCF7, MCF10, MDCK, and fibroblast. The results show successful cell accumulation …

Association Analyses Of Variants In The Dio2 Gene With Early-Onset Type 2 Diabetes Mellitus In Pima Indians, Saraswathy Nair, Yunhua Li Miller, Emilio Ortega, Sayuko Kobes, Clifton Bogardus, Leslie J. Baier

Health & Biomedical Sciences Faculty Publications

Background: The type 2 deiodinase gene (DIO2) encodes a deiodinase that converts the thyroid prohormone, thyroxine, to the biologically active triiodothyronine. Thyroid hormones regulate energy balance and may also influence glucose metabolism. Therefore, we hypothesized that variations in DIO2 could contribute to obesity or type 2 diabetes mellitus (T2DM) in Pima Indians.

Methods: Sequencing of the DIO2 gene in DNA from 83 Pima Indians identified 12 single-nucleotide polymorphisms (SNPs). Several of these SNPs were in perfect genotypic concordance among the 83 samples that were sequenced, and all 12 could be divided into five linkage disequilibrium groups. One representative …

Thermosensitive Magnetic Nanoparticles For Self-Controlled Hyperthermia Cancer Treatment, Karen S. Martirosyan

Physics & Astronomy Faculty Publications

Magnetic nanoparticles show remarkable phenomena such as superparamagnetism, high field irreversibility and high saturation magnetization [1]. The study of magnetic nanoparticles has been a very active research field due to many important applications such as drug delivery, imaging and hyperthermia cancer treatment [2]. Hyperthermia has been used for many years to treat a wide variety of tumors in patients and used as well as an adjunct to cancer radiotherapy or chemotherapy [3,4]. Its use is based on the fact that tumor cells are more sensitive to temperature in the range of 42–45°C (which yields necrosis, coagulation, or carbonization) than normal …

Inhibition Of Bone Loss By Cissus Quadrangularis In Mice: A Preliminary Report, Jameela Banu, Erika Varela, Ali N. Bahadur, Raheela Soomro, Nishu Kazi, Gabriel Fernandes

Health & Biomedical Sciences Faculty Publications

Women drastically loose bone during and after menopause leading to osteoporosis, a disease characterized by low bone mass increasing the risk of fractures with minor trauma. Existing therapies mainly reduce bone resorption, however, all existing drugs have severe side effects. Recently, the focus is to identify alternative medicines that can prevent and treat osteoporosis with minimal or no side effects. We used Cissus quadrangularis (CQ), a medicinal herb, to determine its effects on bone loss after ovariectomy in C57BL/6 mice. Two-month old mice were either sham operated or ovariectomized and fed CQ diet. After eleven weeks, mice were sacrificed and …

Introduction To Positive Psychology: Overview And Controversies, Jeong Han Kim, Phillip Keck, Deborah Miller, Rene Gonzalez

School of Rehabilitation Services & Counseling Faculty Publications

Since his first formal address in 1998 by Martin Seligman, the significant growth and accomplishments of the positive psychology have been universally noted. Notable breakthroughs include the inception of the International Positive Psychology Association in 2007 and the First World Congress of Positive Psychology in 2009. However, much concern has also arisen in conjunction with the development of positive psychology. For example, Gable and Haidt (2005) argued that the assumption of positive psychology implies the rest of the field must be negative psychology. These controversies are not only limited to the foundation of positive psychological principles and understanding the controversies …

Practical Matters: Possibility Versus Probability, Irmo Marini

School of Rehabilitation Services & Counseling Faculty Publications

No abstract provided.

Life Care Plan Implementation Among Adults With Spinal Cord Injuries, Tanya Rutherford-Owen, Irmo Marini

School of Rehabilitation Services & Counseling Faculty Publications

A nationwide survey was conducted to assess life care plan implementation in a sample of 55 adults with spinal cord injuries (SCI) for those with or without a favorable settlement or verdict. Areas of inquiry included disability-related goods and services received following life care plan (LCP) development, differences in the purchasing of LCP items and services between those with and without adequate funding, and implementation differences based on demographic factors. Frequency data and chi-square analyses revealed differences in plan implementation for those who received funding to purchase some items in the life care plan when compared to those who did …

Attendant Care And Spinal Cord Injury: Usage Patterns And Perspectives For Those With Life Care Plans, Tanya Rutherford-Owen, Irmo Marini

School of Rehabilitation Services & Counseling Faculty Publications

The provision of attendant care services is one of the costliest services needed by many individuals following a spinal cord injury (SCI). The current study examined consumption patterns of 55 adults with SCI who had a life care plan developed. Respondents were asked about various aspects of attendant care including number of hours utilized, satisfaction, level and type of care, (i.e. unpaid care versus private hire), received prior to and following life care plan development and settlement. Respondents provided open responses to explain reasons for satisfaction and dissatisfaction with attendant care. Results indicated more respondents received attendant care services following …

Type 2-Diabetes Is Associated With Elevated Levels Of Tnf-Alpha, Il-6 And Adiponectin And Low Levels Of Leptin In A Population Of Mexican American: A Cross-Sectional Study, S. Mirza, Monir Hossain, Christine Mathews, Perla Martinez, Paula Pino, Jennifer L. Gay, Anne R. Rentfro, Joseph B. Mccormick, Susan P. Fisher-Hoch

School of Nursing Faculty Publications

The goal of the study was to determine the association between diabetes and inflammation in clinically diagnosed diabetes patients. We hypothesized that low-grade inflammation in diabetes is associated with the level of glucose control. Using a cross-sectional design we compared pro and anti-inflammatory cytokines in a community recruited cohort of 367 Mexican Americans with type 2-diabetes having a wide range blood glucose levels. Cytokines (IL-6, TNF-α, IL-1β, IL-8) and adipokines (adiponectin, resistin and leptin) were measured using multiplex ELISA. Our data indicated that diabetes as whole was strongly associated with elevated levels of IL-6, leptin, CRP and TNF-α, whereas worsening …

Assessing Dementia In Resource-Poor Regions, Gladys E. Maestre

School of Medicine Publications

The numbers and proportions of elderly are increasing rapidly in developing countries, where prevalence of dementia is often high. Providing cost-effective services for dementia sufferers and their caregivers in these resourcepoor regions poses numerous challenges; developing resources for diagnosis must be the first step. Capacity building for diagnosis involves training and education of healthcare providers, as well as the general public, development of infrastructure, and resolution of economic and ethical issues. Recent progress in some low-to-middle-income countries (LMICs) provides evidence that partnerships between wealthy and resource-poor countries, and between developing countries, can improve diagnostic capabilities. Without the involvement of the …

High Dimensional Endophenotype Ranking In The Search For Major Depression Risk Genes, David C. Glahn, Joanne E. Curran, Anderson M. Winkler, Melanie A. Carless, Matthew P. Johnson, Harald H. H. Goring, Thomas D. Dyer, Ravi Duggirala, Laura Almasy, John Blangero

School of Medicine Publications

Background: Despite overwhelming evidence that major depression is highly heritable, recent studies have localized only a single depression-related locus reaching genome-wide significance and have yet to identify a causal gene. Focusing on family-based studies of quantitative intermediate phenotypes or endophenotypes, in tandem with studies of unrelated individuals using categorical diagnoses, should improve the likelihood of identifying major depression genes. However, there is currently no empirically derived statistically rigorous method for selecting optimal endophentypes for mental illnesses. Here, we describe the endophenotype ranking value, a new objective index of the genetic utility of endophenotypes for any heritable illness.

Methods: Applying endophenotype …

Identifying Risk Factors For Disparities In Breast Cancer Mortality Among African-American And Hispanic Women, Nancy Tian, Pierre Goovaerts, F. Benjamin Zhan, T. Edwin Chow, Jeff Gaines Wilson

School of Earth, Environmental, & Marine Sciences Faculty Publications

Background: This study evaluated the risk factors associated with racial disparities in female breast cancer mortality for African-American and Hispanic women at the census tract level in Texas from 1995 to 2005.

Methods: Data on female breast cancer cases were obtained from the Texas Cancer Registry. Socioeconomic and demographic data were collected from Census 2000. Network distance and driving times to mammography facilities were estimated using Geographic Information System techniques. Demographic, poverty and spatial accessibility factors were constructed using principal component analysis. Logistic regression models were developed to predict the census tracts with significant racial disparities in breast cancer mortality …

Curcumin Nanoformulations: A Future Nanomedicine For Cancer, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion, apoptosis and cell death, revealing its anticancer potential. In this review, we focus on the design and development of nanoparticles, self-assemblies, nanogels, liposomes and complex fabrication for sustained and efficient curcumin delivery. We also discuss the anticancer applications and clinical benefits of nanocurcumin formulations. Only a few novel multifunctional and composite nanosystem strategies offer simultaneous therapy as well as imaging characteristics. We also summarize the challenges to developing curcumin delivery platforms and …

Social Skills As Predictors Of Theory Of Mind Development Among Children, Lucia A. Salinas

Theses and Dissertations - UTB/UTPA

The present study examined relationships among social skills including deceptive behavior, socioeconomic status, and theory of mind development in 98 predominantly Hispanic 3- to 7-year-old children residing in the Rio Grande Valley of Texas. Measures were of vocabulary, deceptive ability, true belief, and false belief understanding. Children’s interactions with others were also measured through observational methods and parental data was obtained to compute socioeconomic status and validate social skills information. It was hypothesized that social skill development, including deception would emerge along with theory of mind understanding in this population, and that children from households of lower socioeconomic status would …

Genetic Influence On The Working Memory Circuitry: Behavior, Structure, Function And Extensions To Illness, Katherine H. Karlsgodt, Peter Bachman, Anderson M. Winkler, Carrie E. Bearden, David C. Glahn

School of Medicine Publications

Working memory is a highly heritable complex cognitive trait that is critical for a number of higher-level functions. However, the neural substrates of this behavioral phenotype are intricate and it is unknown through what precise biological mechanism variation in working memory is transmitted. In this review we explore different functional and structural components of the working memory circuitry, and the degree to which each of them is contributed to by genetic factors. Specifically, we consider dopaminergic function, glutamatergic function, white matter integrity and gray matter structure all of which provide potential mechanisms for the inheritance of working memory deficits. In …