Medicine and Health Sciences Commons^™

Middle Ear Salivary Choristoma: A Rare Case Report And Update On Congenital Associations, Facial Nerve Involvement, And Treatment Strategies, Allen Young, Lauren Evans, Matthew Ng

School of Medicine Faculty Research

Salivary gland choristoma is an extremely rare middle ear mass and is hypothesized to be caused by second branchial arch developmental anomalies. We present a 14-year-old girl with Dandy-Walker syndrome and conductive hearing loss. Middle ear exploration revealed a large middle ear mass with absent incus and stapes and displaced facial nerve. The mass was completely excised with histological confirmation of salivary gland choristoma. Her hearing was improved with bone-anchored hearing aids (BAHA). As facial nerve involvement is common, physicians should consider partial excision to avoid facial nerve palsy. Hearing restoration can be achieved with OCR or BAHA.

Dietary Behaviours Among Han, Tujia And Miao Primary School Students: A Cross-Sectional Survey In Chongqing, China, Zhengjie Cai, Jinli Xian, Xianglong Xu, Ziwei Zhang, Camila Araujo, Manoj Sharma, Yong Zhao

School of Public Health Faculty Research

Background and Purpose: Exploring the differences of children’s dietary behaviours from different nationalities could provide a reference for targeted nutritional interventions. This study aims to assess the dietary behaviours among Han, Tujia and Miao primary school students and the differences among the ethnic groups. Materials and Methods: This cross-sectional survey included 556 primary school students (249 Han, 76 Tujia and 231 Miao students) aged 6– 13 years from the representative minority areas of Chongqing, China. Data were collected with a self-administered or one-on-one interview-based questionnaire encompassing questions on sociodemographics, eating habits and dietary intake. Eating habits and dietary intake were …

Effects Of Caffeinated And Non-Caffeinated Gum On Premotor, Motor, And Overall Reaction Time, Ashton E. Holliday, Maelee A. Wells, Rebecca R. Rogers, Joseph A. Pederson, Tyler Williams, Christopher G. Ballmann

Topics in Exercise Science and Kinesiology

• Chewing gum and caffeine when used independently and concurrently increase neural activity ultimately improving reaction time but less is known about how caffeinated gum influences distinct phases of the reaction time response.
• Physically active college females (n=14) completed a 60-second reaction time test on a visuomotor board under the following counterbalanced conditions: 1) Baseline, 2) Non-caffeinated gum, 3) Caffeinated gum (300 mg caffeine).
• Point of application #1: Chewing gum improved premotor reaction time compared to baseline, but caffeine did not provide additional benefit.
• Point of application #2: Neither non-caffeinated nor caffeinated gum improved motor reaction times from baseline.
• Point of …

Dementia-Related Psychosis And The Potential Role For Pimavanserin, Jeffery L. Cummings, D. P. Devanand, Stephen M. Stahl

School of Medicine Faculty Research

Dementia-related psychosis is prevalent across dementias and typically manifests as delusions and/or hallucinations. The mechanisms underlying psychosis in dementia are unknown; however, neurobiological and pharmacological evidence has implicated multiple signaling pathways and brain regions. Despite differences in dementia pathology, the neurobiology underlying psychosis appears to involve dysregulation of a cortical and limbic pathway involving serotonergic, GABAergic, glutamatergic, and dopaminergic signaling. Thus, an imbalance in cortical and mesolimbic excitatory tone may drive symptoms of psychosis. Delusions and hallucinations may result from (1) hyperactivation of pyramidal neurons within the visual cortex, causing visual hallucinations, and (2) hyperactivation of the mesolimbic pathway, causing …

Active Husband Involvement During Pregnancy: A Grounded Theory, Brandon P. Eddy, Stephen T. Fife

Couple & Family Therapy Program Faculty Research

Objective: The purpose of this grounded theory qualitative study was to build a theory describing how husband involvement during pregnancy impacts the couple relationship. Background: The transition to parenthood presents a significant life change for couples. Although many couples experience this life cycle change, there is relatively little empirical research on how husbands can meaningfully contribute during pregnancy and how husband involvement influences the couple relationship postpartum. Method: Eleven heterosexual, married couples were interviewed regarding husband involvement during the couple's most recent pregnancy. Data collection included separate interviews with each partner and with each couple. Results: The results are presented …

Trc-Pad: Accelerating Recruitment Of Ad Clinical Trials Through Innovative Information Technology, G. A. Jimenez-Maggiora, S. Bruschi, R. Raman, O. Langford, M. Donohue, M. S. Rafii, R. A. Sperling, J. L. Cummings, P. S. Aisen, Trc-Pad Investigators

School of Medicine Faculty Research

Background The Trial-Ready Cohort for Preclinical/ Prodromal Alzheimer's Disease (TRC-PAD) Informatics Platform (TRC-PAD IP) was developed to facilitate the efficient selection, recruitment, and assessment of study participants in support of the TRC-PAD program. Objectives Describe the innovative architecture, workflows, and components of the TRC-PAD IP. Design The TRC-PAD IP was conceived as a secure, scalable, multi-tiered information management platform designed to facilitate high-throughput, cost-effective selection, recruitment, and assessment of TRC-PAD study participants and to develop a learning algorithm to select amyloid-bearing participants to participate in trials of early-stage Alzheimer's disease. Setting TRC-PAD participants were evaluated using both web-based and in-person …

The Trial-Ready Cohort For Preclinical And Prodromal Alzheimer’S Disease (Trc-Pad): Experience From The First 3 Years, S. Walter, O. G. Langford, T. B. Clanton, G. A. Jimenez-Maggiora, R. Raman, M. S. Rafii, E. J. Shaffer, R. A. Sperling, J. L. Cummings, P. S. Aisen, Trc-Pad Investigators

School of Medicine Faculty Research

Background The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's disease (TRC-PAD) aims to accelerate enrollment for Alzheimer's disease (AD) clinical trials by remotely identifying and tracking individuals who are at high risk for developing symptoms of AD, and referring these individuals to in-person cognitive and biomarker evaluation with the purpose of engaging them in clinical trials. A risk algorithm using statistical modeling to predict brain amyloidosis will be refined as TRC-PAD advances with a maturing data set. Objectives To provide a summary of the steps taken to build this Trial-Ready cohort (TRC) and share results of the first 3 years …

The Trial-Ready Cohort For Preclinical/Prodromal Alzheimer’S Disease (Trc-Pad) Project: An Overview, P. S. Aisen, R. A. Sperling, J. L. Cummings, M. C. Donohue, O. Langford, G. A. Jimenez-Maggiora, R. A. Rissman, M. S. Rafii, S. Walter, T. B. Clanton, R. Raman

School of Medicine Faculty Research

The Trial-Ready Cohort for Preclinical/prodromal Alzheimer’s Disease (TRC-PAD) project is a collaborative effort to establish an efficient mechanism for recruiting participants into very early stage Alzheimer’s disease trials. Clinically normal and mildly symptomatic individuals are followed longitudinally in a web-based component called the Alzheimer’s Prevention Trial Webstudy (APT Webstudy), with quarterly assessment of cognition and subjective concerns. The Webstudy data is used to predict the likelihood of brain amyloid elevation; individuals at relatively high risk are invited for in-person assessment in the TRC screeing phase, during which a cognitive battery is administered and Apolipoprotein E genotype is obtained followed by …

Predicting Amyloid Burden To Accelerate Recruitment Of Secondary Prevention Clinical Trials, O. Langford, R. Raman, R. A. Sperling, J. Cummings, C.-K. Sun, G. Jimenez-Maggiora, P. S. Aisen, M. C. Donohue, Trc-Pad Investigators

School of Medicine Faculty Research

Background: Screening to identify individuals with elevated brain amyloid (Aβ+) for clinical trials in Preclinical Alzheimer’s Disease (PAD), such as the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s disease (A4) trial, is slow and costly. The Trial-Ready Cohort in Preclinical/Prodromal Alzheimer’s Disease (TRC-PAD) aims to accelerate and reduce costs of AD trial recruitment by maintaining a web-based registry of potential trial participants, and using predictive algorithms to assess their likelihood of suitability for PAD trials. Objectives: Here we describe how algorithms used to predict amyloid burden within TRC-PAD project were derived using screening data from the A4 trial. Design: We apply machine …

Recruitment Into The Alzheimer Prevention Trials (Apt) Webstudy For A Trial-Ready Cohort For Preclinical And Prodromal Alzheimer’S Disease (Trc-Pad), S. Walter, T. B. Clanton, O. G. Langford, M. S. Rafii, E. J. Shaffer, J. D. Grill, G. A. Jimenez-Maggiora, R. A. Sperling, J. L. Cummings, P. S. Aisen, Trc-Pad Investigators

School of Medicine Faculty Research

Background The Alzheimer Prevention Trials (APT) Webstudy is the first stage in establishing a Trial-ready Cohort for Preclinical and Prodromal Alzheimer's disease (TRC-PAD). This paper describes recruitment approaches for the APT Webstudy. Objectives To remotely enroll a cohort of individuals into a web-based longitudinal observational study. Participants are followed quarterly with brief cognitive and functional assessments, and referred to Sites for in-clinic testing and biomarker confirmation prior to enrolling in the Trial-ready Cohort (TRC). Design Participants are referred to the APT Webstudy from existing registries of individuals interested in brain health and Alzheimer's disease research, as well as through central …

Sound Effects On Standing Postural Strategies In The Elderly Via Frequency Analysis Approach, Yun-Ju Lee, Chang-Hsu Chen, Chao-Che Wu, Yu-Jung Chen, Jing-Nong Liang

Physical Therapy Faculty Research

Sound and sound frequency could improve postural sway in the elderly. The power spectrum intervals of the center of pressure (COP) displacement are associated with different postural regulations, which could be revealed by frequency analysis. The aim of the study was to investigate the effects of sound on dual-tasking postural control and conduct frequency analysis to distinguish postural regulations in the elderly. Fifteen young and 15 older healthy participants were instructed to stand on a force platform and performed the Purdue Pegboard test while hearing 50 dB sounds with sound frequencies of 250 Hz, 1000 Hz, 4000 Hz, or no …

Acute Systemic Inflammation Reduces Both Carotid And Aortic Wave Reflection In Healthy Adults, Thessa Hilgenkamp, Elizabeth C. Schroeder, Wesley L. Lefferts, Bo Fernhall

Physical Therapy Faculty Research

Acute inflammation increases the risk of cardiac and cerebrovascular events, possibly related to alterations in the hemodynamic load. Wave reflection at the aorta and carotid provides insight into downstream vascular changes and hemodynamic load at the heart and brain. Acute inflammation has been suggested to reduce wave reflection via downstream vasodilation; however, this is not firmly established and has only been investigated at the aorta. We sought to explore the effect of acute inflammation on aortic and carotid hemodynamics in healthy, young adults. Pressure waveforms were collected via radial and carotid applanation tonometry in 23 adults (26 ± 4 years) …

Tricyclic Antidepressant Use And Risk Of Fractures: A Meta-Analysis Of Cohort Studies Through The Use Of Both Frequentist And Bayesian Approaches, Qing Wu, Yingke Xu, Yueyang Bao, Jovan Alvarez, Mikee Lianne Gonzales

School of Medicine Faculty Research

Background: Research findings regarding the association between tricyclic antidepressant (TCA) treatment and the risk of fracture are not consistent; we aimed to assess whether people who take TCAs are at an increased fracture risk. Methods: Relevant studies published through June 2020 were identified through database searches of MEDLINE, EMBASE, Scopus, PsycINFO, ISI Web of Science, WorldCat Dissertations and Theses from each database’s inception, as well as through manual searches of relevant reference lists. Two researchers independently performed literature searches, study selection, data abstraction and study appraisal by using a standardized protocol. Frequentist and Bayesian hierarchical random-effects models were used for …

Interplay Of Trna-Derived Fragments And T Cell Activation In Breast Cancer Patient Survival, Nayang Shan, Ningshan Li, Qile Dai, Lin Hou, Xiting Yan, Amei Amei, Lingeng Lu, Zuoheng Wang

Mathematical Sciences Faculty Research

Effector CD8+ T cell activation and its cytotoxic function are positively correlated with improved survival in breast cancer. tRNA-derived fragments (tRFs) have recently been found to be involved in gene regulation in cancer progression. However, it is unclear how interactions between expression of tRFs and T cell activation affect breast cancer patient survival. We used Kaplan–Meier survival and multivariate Cox regression models to evaluate the effect of interactions between expression of tRFs and T cell activation on survival in 1081 breast cancer patients. Spearman correlation analysis and weighted gene co-expression network analysis were conducted to identify genes and pathways that …

Bk Virus Nephropathy: Prevalence, Impact And Management Strategies, Rajeev Sharma, Mareena Zachariah

School of Medicine Faculty Research

BK virus reactivation as a result of therapeutic immunosuppression following renal transplant can result in BK polyomavirus nephropathy and renal allograft loss. This is a complex and challenging clinical problem with a range of management options and practices reported in literature. The current standard for early diagnosis and treatment is surveillance by measuring viral DNA in blood using qPCR. Immunosuppression reduction is the cornerstone of effective management but is associated with a risk of acute rejection following treatment.

Assessment Of Real-World Use Of Behavioral Health Mobile Applications By A Novel Stickiness Metric, Andrew D. Carlo, Reza H. Ghomi Md, Mse, Brenna N. Renn Phd, Michael A. Strong Md, Patricia A. Areán Phd

Psychology Faculty Research

Digital health treatments for individuals with behavioral health problems are increasing rapidly in number.1,2 Studies to date have demonstrated that longitudinal patient engagement is challenging,3,4 making it unlikely for most applications (hereafter, apps) to effect real-world change. In this cross-sectional study, we describe usage patterns of popular mobile behavioral health apps and identify characteristics of those that are most continually accessed (also known as the stickiest),5 with the aim of informing future research on behavioral health app engagement.

Use Of Pericranial Flaps With Dermal Substitute For Scalp Reconstruction: A Case Series, Kongkrit Chaiyasate Md, Facs, Lauren N. Oliver Do, Scott A. Kreitzberg Do, Mitchell Lyons Md, Joshua Goldman Md, Stephen M. Lu Md, Tracey Bastiaans Do, Christopher Lumley Do, Neil S. Sachanandani Md

School of Medicine Faculty Research

Background: Skin cancer incidence has been rapidly increasing over the past 2 decades, and the resulting defects from excision have significant aesthetic and functional implications. In particular, wound coverage for large scalp and forehead defects with calvarial exposure can lead to hairline distortion, contour irregularities, and alopecia. We describe a 2-stage technique for scalp reconstruction, which preserves the normal hairline, covers exposed bone with vascularized tissue, and restores an aesthetic soft-tissue contour. Methods: This is a retrospective case series of 13 adults with ages ranging from 50 to 89 years. All patients underwent Mohs surgery on the forehead or scalp …

Functional Capacity Profiles In Bipolar Disorder And Schizophrenia, Ashley Sara Emami

UNLV Theses, Dissertations, Professional Papers, and Capstones

Serious mental illnesses (SMIs) often have an onset early in life and go on to produce disability and functional impairment, which require ongoing supportive services and loss of productivity. Bipolar disorder (BD) and schizophrenia (SZ) are two of the most common SMIs. BD and SZ differ in their pattern of neurocognitive performance, which suggests differences in the severity of functional impairment between the illness groups. Within these psychiatric illness groups, subgroups may also be identified using cluster analysis. Evidence points to heterogeneity in functional outcomes in BD and SZ, yet very little research has assessed for subgroups based on functional …

An Intervention To Increase Nurses’ Knowledge Of Non-Opioid Pain Management In Post-Operative Elective Knee And Hip Replacement Patients, Kristen K. Grunerud

UNLV Theses, Dissertations, Professional Papers, and Capstones

Post-operative pain control is an enduring problem in health care. The extensive use of opioids since the 1980s has contributed to the current opioid crisis in the United States. In response, healthcare providers have begun to use a more biopsychosocial model to address pain control needs of patients. There is a demonstrated gap in knowledge for nurses in this area, and recent changes to hospital accreditation standards include a requirement to demonstrate both education provisions to staff and the use of non-opioid methods to control pain. The purpose of this Doctor of Nursing Practice (DNP) project was to assess, and …

The Influence Of Cerebellar Transcranial Direct Current Stimulation On Motor Function In Parkinson’S Disease, Lidio Lima De Albuquerque

UNLV Theses, Dissertations, Professional Papers, and Capstones

Parkinson's disease (PD) is the most common movement disorder and the second most common neurodegenerative disorder. PD is characterized by dopaminergic cell loss in the substantia nigra pars compacta, which leads to a reduction in dopamine in the striatum. These physiological mechanisms lead to a number of motor impairments such as bradykinesia, rigidity, tremor, and postural instability that severely limit the ability of individuals with PD to perform many essential daily living activities. Although current pharmacological, surgical, and physical exercise treatment approaches are valuable they are either only mildly effective, expensive, or associated with a variety of side effects. Therefore, …

Sexually Transmitted Infections And The 65 And Older Population: Knowledge And Perceived Risk, Alexus Miranda

UNLV Theses, Dissertations, Professional Papers, and Capstones

Sexually transmitted infections (STI) can impact all persons. Since 2000, the number of STIs has steadily increased among persons aged 50 years and older in the United States (Purpora, 2012). Persons over the age of 60 accounted for the biggest increase of in-office treatments of STIs between 2014 and 2017 (Howley, 2018). The purpose of this study was to use the Sexual Health Model to examine the relationship between various predictors and these persons’ perceived risk of STIs, their STI knowledge, and other barriers that impact the sexual health of persons 65 years of age and older. This study used …

Factors Affecting Esophageal Tissue Radiation Response, Latisha T. Pryor

UNLV Theses, Dissertations, Professional Papers, and Capstones

Radiation-induced esophageal cancer can be a deadly and unfortunate secondary outcome of radiotherapy or chronic occupational exposure to radiation. Although the esophagus is known to be a radiosensitive organ, it is under studied and further information regarding how dose and radiation quality impact its sensitivity may provide strategies to prevent esophageal cancer. The purpose of this thesis was to understand factors that play a role in the tissue’s radiosensitivity that may relate to its cancer risk. In this study, we used two esophageal 3D models, as well as both human and mouse cells, to define radiation quality and dose dependent …

Memory And Stereotypes For Lesbian/Gay Characters, Amber Rose Williams

UNLV Theses, Dissertations, Professional Papers, and Capstones

Stereotype-consistency bias refers to the idea that people tend to remember stereotypical information about others better than non-stereotypical information (Fyock & Stangor, 1994). Limited research has examined how people may use stereotype-consistency bias when recalling information about LGBT characters in narratives (Bellezza & Bower, 1981; Clark & Woll, 1981; McGann & Goodwin, 2007; Snyder & Uranowitz, 1978). This line of research suggests that, instead of genuinely remembering stereotypical information better, participants tended to guess stereotypical answers to questions they do not know. In contrast to those studies, the experiment I conducted for this thesis suggests that heterosexual young adults tend …

Rejection Sensitivity And The Intent To Seek Medical Help Among Gender Minority Individuals, Kellyann Garthe

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: As members of a marginalized and socially devalued group, gender minority (GM) individuals regularly experience rejection in healthcare experiences. These rejecting experiences lead to barriers to healthcare access and health disparities. Consequently, GM individuals’ may develop anxious and avoidant attitudes toward their healthcare needs. When considering healthcare, an individual’s inherent attitude informs their intent to seek medical help (ISMH), defined as the attitude that influences one’s decision to seek medical help. When an individual has a hyper-sensitive reaction to perceived rejection, this is termed rejection sensitivity (RS).

Purpose: The purpose of the study was to determine if the independent …

The Prevalence And Predictors Of Complementary And Alternative Medicine (Cam) Use Among Racially/Ethnically Diverse College Students, Hermella Misiker

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: National data on complementary and alternative medicine (CAM) use, available through the National Health Interview Survey (NHIS), convey higher prevalence of CAM use among college students compared to the general U.S population. NHIS findings also highlight non-vitamin non- mineral (NVNM) products are the most widely used form of CAM in the U.S. The purpose of this study was to identify the socio-cognitive and demographic predictors of CAM and NVNM use among a racially/ethnically diverse college student body.

Methods: An online survey was used to collect data from 392 University of Nevada, Las Vegas (UNLV) undergraduate, graduate, and professional students. …

Examination Of Factors Reported By Athletes To Interfere With Their Lives Outside Of Sports, Jesse Scott

UNLV Theses, Dissertations, Professional Papers, and Capstones

The original Sport Interference Checklist (SIC) is a mental-health screening instrument designed to assess the extent to which mental health factors interfere with athletes’ performance during sport training or competition. In addition, the SIC appraises whether athletes are interested in pursuing psychological treatment for the aforementioned factors. Although validated, the SIC does not assess how the aforementioned factors affect athletes’ performance outside of sports. Doing so would permit professionals to examine the influence of these factors across sport training, sport competition, and life outside of sports.

The purpose of this study was to determine the psychometric properties and clinical utility …

Catholic Family Ties: Sustaining And Supporting Hiv-Positive Canadian Gay Men’S Faith, Mental Health, And Wellbeing, Renato M. Liboro

Psychology Faculty Research

Research has documented that sexual minorities and people living with HIV/AIDS have successfully used religious coping to help them overcome life challenges related to their sexual orientation and HIV status, including religious struggles surrounding their faith brought about by stigma and discrimination that have historically been promoted by organized religion. Research has also documented how sexual minorities and people living with HIV/AIDS have utilized family support as a vital resource for effectively coping with life challenges associated with homophobia, heterosexism, and HIV stigma, which have historically been perpetuated in certain family and faith dynamics. The aim of the community-engaged, qualitative …

Machine Learning Approaches For Fracture Risk Assessment: A Comparative Analysis Of Genomic And Phenotypic Data In 5130 Older Men, Qing Wu, Fatma Nasoz, Jongyun Jung, Bibek Bhattarai, Mira V. Han

School of Public Health Faculty Research

The study aims were to develop fracture prediction models by using machine learning approaches and genomic data, as well as to identify the best modeling approach for fracture prediction. The genomic data of Osteoporotic Fractures in Men, cohort Study (n = 5130), were analyzed. After a comprehensive genotype imputation, genetic risk score (GRS) was calculated from 1103 associated Single Nucleotide Polymorphisms for each participant. Data were normalized and split into a training set (80%) and a validation set (20%) for analysis. Random forest, gradient boosting, neural network, and logistic regression were used to develop prediction models for major osteoporotic fractures …

Mir-365 (Microrna): Potnetial Biomarker In Oral Squamous Cell Carcinoma Exosomes And Extracellular Vesicles, Jeffery Coon, Karl Kingsley, Katherine M. Howard

Dental Medicine Faculty Research

Introduction: miR-365 is a non-coding microRNA that regulates transcription and has been demonstrated to promote oncogenesis and metastasis in some cancers, while suppressing these effects in others. Many microRNAs are produced and then exported extracellularly in exosomes, which are small extracellular vesicles ranging from 30 to 100 nm that are found in eukaryotic fluids and facilitate many cellular functions. Exosomes and extracellular vesicles are produced by many cell types, including oral cancer cells—although no study to date has evaluated miR-365 and oral cancer exosomes or extracellular vesicles. Based on this information, our research question was to evaluate whether oral cancers …

Efficacy Of Manual Hemostasis For Percutaneous Axillary Artery Intra-Aortic Balloon Pump Removal, Rajiv Tayal, Michael Divita, Christoph W. Sossou, Alexis K. Okoh, Kelly Stelling, James M. Mccabe, Amir Kaki, Najam Wasty, David A. Baran

School of Medicine Faculty Research

Background. The prevalence of peripheral vascular disease has led to the re-emergence of percutaneous axillary vascular access as a suitable alternative access site to femoral artery. We sought to investigate the efficacy and safety of manual hemostasis in the axillary artery. Methods. Data were collected from a prospective internal registry of patients who had a Maquet® (Rastatt, Germany) Mega 50 cc intra-aortic balloon pumps (IABP) placed in the axillary artery position. They were anticoagulated with weight-based intravenous heparin to maintain an activated partial thromboplastin time (aPTT) of 50-80 seconds. Anticoagulation was discontinued 2 hours prior to the device explantation. Manual …