Medicine and Health Sciences Commons^™

Performance Of Urine Reagent Test Strips In Detecting Schistosoma Haematobium Infection In Individual And Pooled Urine Samples, Abraham Degarege, Berhanu Erko, David Brett-Major, Bruno Levecke, Abebe Animut, Yohannes Negash, M. Jana Broadhurst, Tzeyu L. Michaud, Christopher R. Bilder

Journal Articles: Epidemiology

This study evaluated the performance of urine reagent strips (URSs) in detecting Schistosoma haematobium infection in individual and pooled urine samples. Between June 2022 and April 2023, 2634 urine samples (10 mL each) from school-age children (5-15 years) in 15 villages across Ethiopia's Afar, Benishangul-Gumuz, and Gambella regions were tested using urine filtration microscopy (UFM) and URSs for blood, a marker of S. haematobium eggs. Pooled samples from 5, 10, 20, and 40 individuals (one positive, others negative) were examined with both methods. UFM results were used to calculate URSs' sensitivity, specificity, and predictive values for detecting infection. A total …

Quantifying The Public Health Impact Of Lyme Disease In Minnesota: A Simulation Analysis Of Reported And Unreported Cases, Kathleen Angell, M. Jana Broadhurst, Jianghu James Dong, Tzeyu L. Michaud, Abraham Degarege, Roberto Cortinas, David Brett-Major

Journal Articles: Epidemiology

Background: Lyme disease, the most common vector-borne disease in Minnesota, is estimated to be underreported by a factor of 10. Delayed diagnosis and misdiagnosis may lead to health complications and increased personal and societal costs. Environmental factors can help to predict high disease years, allowing for early intervention to decrease disease burden. Objective: To estimate the health and cost burdens of Lyme disease and the extent to which they could be diminished by public health intervention when high-incidence Lyme disease years are forecasted. Methods: We used 5 two-dimensional Monte Carlo simulations to estimate (1) average annual expected burden of Lyme …

Pregnancy Outcomes After Exposure To Tuberculosis Treatment In Phase 3 Clinical Trial, 2016-2020, Ekaterina V. Kurbatova, William C. Whitworth, Kia E. Bryant, Meredith G. Dixon, Kelly E. Dooley, Nigel A. Scott, Rosanna Boyd, Nicole E. Brown, Kimberley N. Chapman Hedges, Wendy Carr, Lakshmi P. Peddareddy, Grace Muzanyi, Rodney Dawson, Ziyad Waja, Neil Martinson, Jyoti S. V. Mathad, Payam Nahid, Susan Swindells, Richard E. Chaisson, Susan E. Dorman, Patrick P. J. Phillips, Aids Clinical Trials Group A5349, Tuberculosis Trials Consortium Study 31

Journal Articles: Infectious Diseases

A previous study demonstrated noninferior efficacy of 4-month rifapentine/moxifloxacin regimen for tuberculosis (TB) treatment compared with the standard regimen. We analyzed pregnancy outcomes of women who became pregnant during the study. Among 740 women, 97 (13.1%) became pregnant. Of 102 pregnancies (in 97 participants), 30 (29.4%) participants were exposed to study drugs. Fetal loss was reported for 3/13 (23.1%) in the control regimen, 1/9 (11.1%) in the rifapentine/moxifloxacin regimen, and 1/8 (12.5%) in the rifapentine regimen. Among 21 live births in exposed pregnancies (7 in each arm), 1 infant with a congenital anomaly was reported in a participant on the …

Lower Electronic Health Record Adoption And Interoperability In Rural Versus Urban Physician Participants: A Cross-Sectional Analysis From The Cms Quality Payment Program, Alfred J. Anzalone, Carol R. Geary, Ran Dai, Shinobu Watanabe-Galloway, James C. Mcclay, James Campbell

Journal Articles: Epidemiology

BACKGROUND: The Health Information Technology for Economic and Clinical Health Act of 2009 introduced the Meaningful Use program to incentivize the adoption of electronic health records (EHRs) in the U.S. This study investigates the disparities in EHR adoption and interoperability between rural and urban physicians in the context of federal programs like the Medicare Access and CHIP Reauthorization Act of 2015 and the 21st Century Cures Act.

METHODS: A cross-sectional analysis was conducted using the 2021 Quality Payment Program Experience Report Public Use File to compare EHR adoption and Promoting Interoperability scores (PISs) between urban and rural physician participants. Data …

Ambient Air Pollution And Survival Among Black Women With Epithelial Ovarian Cancer Across Diverse Geographical Regions Of The United States, Ekaterina Chirikova, Courtney E. Johnson, Anke Huels, Pushkar P. Inamdar, Elisa V. Bandera, Lawrence H. Kushi, Jennifer A. Doherty, Joellen M. Schildkraut, Hari S. Iyer, Melissa Bondy, Edward S. Peters, Kendra L. Ratnapradipa, Jeffrey Marks, Christopher Pierson, Theresa Hastert, Kristin Haller, Grace Christensen, Salma Shariff-Marco, Scarlett L. Gomez, Andrew Lawson

Journal Articles: Epidemiology

Background: Ovarian cancer is a leading cause of gynecologic cancer mortality, with Black women experiencing 5-year survival rates of only 41%. Disproportionate air pollution exposure may impact survival. We evaluated associations of fine particulate matter (PM_2.5) and nitrogen dioxide (NO₂) exposure with survival among Black women with epithelial ovarian cancer using data from the California Cancer Registry (CCR, n = 540) and the multi-state African American Cancer Epidemiology Study (AACES, n = 766).

Methods: Annual PM_2.5 and NO₂ levels were estimated at a 1 km resolution using well-validated ensemble-based prediction models derived from the …

Spleen And Peripheral Blood Immunopathology In An Outbred Model Of Adult-Stage Murine Schistosomiasis, Thomas Schulze, Andrew J. Neville, Evie G. Ehrhorn, Sarah A. Alsuleiman, Jonathan L. Vennerstrom, Paul H. Davis

Journal Articles: Pharmaceutical Sciences

Schistosomiasis, a parasitic disease caused by flatworms of genus Schistosoma, is a neglected tropical disease that causes significant morbidity in the developing world. Despite numerous efforts to eradicate the disease, the parasite remains a significant global burden, particularly within Sub-Saharan Africa. Schistosoma species possess an arsenal of potent mechanisms to defend against direct attack from host immune cells and a remarkable ability to modulate the host immune system through proximal and systemic modes that facilitate its stage-specific development, survival, and reproduction. Standardized animal models have been developed that serve as an important resource for dissecting parasite and host immunobiology …

Targeted Deletion Of Cxcl1 In Mscs Regulates Osteogenesis And Suppresses Bone-Metastatic Prostate Cancer, Catherine S. Johnson, Diane L. Costanzo-Garvey, Julio C. Valencia, Sanjana Rajgopal, Theodore Reed, Emma R. Brannon, Jeremy S. Frieling, Deanna Mosley, Todd A. Wyatt, Elijah F. Edmondson, Kabhilan Mohan, Grinu Mathew, Leah M. Cook

Journal Articles: Environmental, Agricultural & Occupational Health

Bone metastasis continues to be the greatest challenge in treating patients with prostate cancer despite ongoing research. In bone, prostate cancer tumors hijack normal bone remodeling processes to drive cancer progression. However, it is unclear how these interactions drive bone-metastatic prostate cancer growth in the bone environment. To understand the mechanisms associated with bone-metastatic prostate cancer regulation of mesenchymal stem cells (MSC), we previously identified that bone-metastatic prostate cancer induces MSC expression of the pro-inflammatory chemokine CXCL8 and its mouse functional homologue Cxcl1. To date, there has been little to no information about the role of CXCL1/8 in MSC biology …

Sars-Cov-2 Genomic Surveillance Using Self-Collected Saliva Specimens During Occupational Testing Programs, Andy T. Schnaubelt, David Brett-Major, Janet Williamson, Bailey Barcal, Julie Carstens, Ashley Peer, Michael R. Wiley, M. Jana Broadhurst

Journal Articles: Epidemiology

Continually emerging SARS-CoV-2 variants pose challenges to clinical and public health interventions, necessitating sustainable approaches to real-time variant monitoring. This case study describes an innovative SARS-CoV-2 screening and surveillance program that demonstrates the utility of sequencing-based variant monitoring using self-collected saliva specimens. We conducted saliva-based SARS-CoV-2 screening in occupational settings in Omaha, Nebraska from December 2021 through November 2022. 8,372 saliva specimens collected from 1,480 participants were tested for SARS-CoV-2 RNA by extraction-free PCR, with 334 positive samples referred for whole-genome sequencing analysis. Program utilization, quality metrics, and sequencing outputs were compared across sites. Specimen quality was high across program …

Efficacy And Safety Of 4-Month Rifapentine-Based Tuberculosis Treatments In Persons With Diabetes., Ekaterina V. Kurbatova, William C. Whitworth, Lakshmi Praveena Peddareddy, Patrick P. J. Phillips, Nigel A. Scott, Kia E. Bryant, Rodney Dawson, Sandra Wagner Cardoso, Wadzanai Samaneka, Melissa Engle, Ziyaad Waja, Erin Sizemore, Wendy Carr, Kelly E. Dooley, Radojka Savic, Susan Swindells, Richard E. Chaisson, Susan E. Dorman, Payam Nahid, Nhung V. Nguyen, Aids Clinical Trials Group A5349, Tuberculosis Trials Consortium Study 31

Journal Articles: Infectious Diseases

A previous study demonstrated noninferior efficacy of 4-month rifapentine/moxifloxacin regimen for tuberculosis (TB) treatment compared with the standard regimen. We explored results among study participants with diabetes. Among 2,516 randomized participants, 181 (7.2%) had diabetes. Of 166 participants with diabetes in the microbiologically eligible analysis group, 26.3% (15/57) had unfavorable outcomes in the control regimen, 13.8% (8/58) in the rifapentine/moxifloxacin regimen, and 29.4% (15/51) in the rifapentine regimen. The difference in proportion of unfavorable outcomes between the control and rifapentine/moxifloxacin arms in the microbiologically eligible analysis group was -12.5% (95% CI -27.0% to 1.9%); the difference between the control and …

Perspective On Alcohol-Induced Organ Damage Via Autophagy-Dependent Cellular Changes, Ahmed Bakheet, Murugadas Anbazhagan, Shirish Barve, Srinivasan Dasarathy, John Dickinson, Wen-Xing Ding, Terrence Donohue, Thiyagarajan Gopal, Anna Gukovskaya, Kusum K. Kharbanda, John J. Lemasters, Natalia A. Osna, Pal Pacher, Lucy Sloan, Luis F. Vilches, Viswanathan Saraswathi, Xiao-Ming Yin, Zhi Zhong, Paul G. Thomes

Journal Articles: Internal Medicine

Alcohol-induced organ damage is a major global health concern and a leading cause of disability and mortality. In addition to the liver, chronic alcohol consumption adversely affects multiple organ systems, including the cardiovascular and neuromuscular systems, the gastrointestinal tract, adipose tissue, kidneys, pancreas, and the brain. Organ damage begins with necrosis (cell death) followed by tissue injury, which triggers immune responses aimed at tissue repair. However, with continued heavy drinking, these reparative responses transition into inflammatory responses which exacerbate tissue injury and accelerate disease progression. Macroautophagy, commonly referred to as autophagy, is a vital and evolutionarily-conserved digestive process in eukaryotic …

Week 96 Results Of Bictegravir/Emtricitabine/Tenofovir Alafenamide For Hiv Treatment In People With Substance Use Disorders, Joshua P. Havens, Sara Bares, Elizabeth Lyden, Nada A. Fadul, Susan Swindells

Journal Articles: Infectious Diseases

BACKGROUND: The BASE study (NCT03998176), a phase 4, 48-week (W), single-arm, prospective trial, revealed that the use of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in people with HIV and substance use disorders (PWH/SUD) was safe and effective without emergent antiretroviral resistance despite incomplete adherence. Here, we present the W96 results.

METHODS: A retrospective analysis of all participants enrolled in the BASE study was completed from W48 to W96. End points of interest at W96 included the proportion of participants with viral suppression (VS; HIV RNA < 50 copies/mL [c/mL]), incidence of protocol-defined virologic failure (PDVF; 2 consecutive ≥400 c/mL), safety, adherence (percentage of days covered [PDC]), retention in care, and prevalence of ongoing substance use.

RESULTS: All enrolled BASE participants (n = 43) were included in the W96 analysis. At W48, 21 participants …

Targeting Cancer-Associated Fibroblast-Driven Lif/Lifr Axis Improves The Therapeutic Efficacy Of Gemcitabine And Nab-Paclitaxel In Pancreatic Cancer, Rakesh Bhatia, Imran Khan, Xiaoqi Li, Shailendra Gautam, Parthasarathy Seshacharyulu, Zahraa Wajih Alsafwani, Namita Bhyravbhatla, Moorthy P. Ponnusamy, Maneesh Jain, Mokenge Malafa, Santhamma Bindu, Ahmed Gulzar, Hareesh Nair, Surinder K. Batra, Sushil Kumar

Journal Articles: Biochemistry & Molecular Biology

Pancreatic ductal adenocarcinoma (PDAC) is inherently therapy resistant due to cancer cell-stroma crosstalk across several signaling pathways. Among these, the LIF/LIFR axis has been implicated in cancer cell and cancer-associated fibroblast (CAF) crosstalk. We evaluated the efficacy of EC359, a competitive inhibitor of LIFR, in combination with gemcitabine. EC359 reduced tumor burden by 90% compared to controls and by 55% compared to gemcitabine alone in cancer cell and CAFs co-implannation model. The RNA-seq analysis revealed a significant alteration in extracellular matrix components, stemness, microtubule assembly, and immune response, suggesting simultaneous targeting of cancer cell-intrinsic and stroma-mediated mechanisms by EC359. In …

Understanding The Pathogenesis Of Uveitis In Ebola Virus Disease Survivors: An Observational Cohort And Cross-Sectional Study Protocol For Clinical, Molecular Virologic And Immunologic Characterisation, Caleb D. Hartley, Susanne Linderman, Tolulope Fashina, Laura Ward, Carolyn Drews-Botsch, Catherine Pratt, Sanjana Kuthyar, Alcides Filho Fernandes, Ye Huang, Charlene Choo, Nam Nguyen, Jessica Carag, Jill Morgan, Colleen S. Kraft, Angela L. Hewlett, David Brett-Major, John S. Schieffelin, Robert F. Garry, Donald Grant, Grant A. Justin, Christopher D. Conrady, Justine R. Smith, Brent R. Hayek, Shiama Balendra, Nisha Acharya, Thuy Doan, Anais Legand, Pierre Formenty, Xiankun Zeng, Ibrahim Conteh, Matthew Jusu Vandy, Lloyd Harrison-Williams, Jalikatu Mustapha, Zikan Koroma, Michael R. Wiley, Ian Crozier, Jean-Claude Mwanza, Jessica G. Shantha, Rafi Ahmed, Steven Yeh, Smile And Evict-Vr Investigator Study Groups

Journal Articles: Epidemiology

INTRODUCTION: The 2013-2016 Western African outbreak of the Ebola virus disease (EVD), the largest recorded outbreak since the discovery of Ebola virus (EBOV) in 1976, destabilised local health systems and left thousands of survivors at risk for postacute sequelae, including vision-threatening uveitis. In an EVD survivor with severe panuveitis, the detection of persistent EBOV in the aqueous humour, long after clearance of acute viremia, focused clinical and research attention on the host-EBOV interaction in the unique terrain of ocular immune privilege. Despite the recognition that uveitis is common and consequential in EVD survivors, our understanding of pathogenesis is extremely limited, …

Editing Approaches To Treat Alpha-1 Antitrypsin Deficiency, Derek M. Erion, Leah Y. Liu, Christopher R. Brown, Stephen I. Rennard, Humam Farah

Journal Articles: Pulmonary & Critical Care Med

TOPIC IMPORTANCE: Alpha-1 antitrypsin (AAT) deficiency is a genetic disorder most commonly due to a single G to A point mutation (E342K), leading to debilitating lung and/or liver disorders and is associated with increased mortality. The E342K point mutation causes a conformational change of the AAT protein resulting in its retention in liver hepatocytes. This reduces AAT secretion into the serum resulting in higher protease activities due to the lack of inhibition from AAT, causing damage to healthy lung tissue. The current standard of care for lung manifestations involves weekly IV augmentation therapy and is considered suboptimal for these patients. …

App Assisted Depression Self-Management In Integrated Primary Care: A Pilot Study Exploring Patient And Provider Experiences, David J. Johnson, Margaret R. Emerson, Danae Dinkel, Robbin Thomas, Shinobu Watanabe-Galloway, Maria S. Mickles, Carli Culjat

Journal Articles: Epidemiology

The integrated primary care (IPC) setting is currently the de facto institution for accessing mental healthcare among underserved populations. However, many barriers exist for these populations when seeking regular and adequate mental healthcare, including provider availability and transportation challenges. This study piloted the incorporation of mindLAMP, a mHealth app, into IPC treatment to offer a low-resource intervention designed to improve and expand access to mental healthcare for underserved patients between face-to-face visits. This study gathered data from a sample of both behavioral health providers and patients (N = 6) in IPC settings to pilot the use of the mindLAMP app …

The Collaborative Care Model And Depression Mediation Adherence, Remmy Rocha, Megan Mcclain, Anusha Mubin, Nicholas Morgenstern, Makenzie Maroney, Melanie Menning, Shannon Kinnan, Ryan W. Walters

Posters and Presentations: Family Medicine

No abstract provided.

When The Storm Clears: Stories Of Life Beyond Chronic Illness, Marie Bernard, David Mercer, Linda Bernard, Simone Bernard

EMET Projects

This book is a collection of personal stories from patients at the Intestinal Rehabilitation Clinic at the University of Nebraska Medical Center. Each of them shares a common thread of living with Short Bowel Syndrome (SBS) — but this book is not about their diagnosis alone. It is about their lives outside of it: the ordinary, extraordinary, and uniquely personal experiences that make them who they are.

Protocol For Screening Of Small Molecules In A Cln3 Disease Patient-Specific Ipsc-Derived Neuronal Progenitor Cell Model, Ramu Venkatesan, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

Although rare, CLN3 disease is the most common neurodegenerative disorder of childhood. Here, we present a protocol for screening small molecules in a CLN3 disease patient-specific induced pluripotent stem cell (iPSC)-derived neuronal progenitor cell (NPC) model. We describe steps for converting human iPSCs (hiPSCs) to neural stem cells (NSCs) and developing NPCs using feeder-free medium and cytokine-based differentiation. We then detail procedures for achieving access to mature neurons. For complete details on the use and execution of this protocol, please refer to Simeon et al.

Editors’ State Of The Journal, Nancy E. Krusen, Stacy Smallfield, M Nicole Martino

Translational Science in Occupation

No abstract provided.

The Power Of Podcasting In Knowledge Translation For Occupational Therapy, Matthew C. Brandenburg

Translational Science in Occupation

No abstract provided.

Value Of Case Studies For Translating Evidence In Occupational Therapy: A New 3-Dimensional Model, George S. Tomlin, Bonnie Riley, Aimee Piller, Jessica Mchugh Conlin, Ashlea D. Cardin, Katrina M. Serwe, Deborah A. Dougherty

Translational Science in Occupation

Importance: Occupational therapy (OT) practitioners often address complex occupational performance needs of diverse consumers. Professional reasoning, theory, and trial and error interventions can be demonstrated in case studies. Case studies are usually relegated to the lowest level in evidence hierarchies. Yet they have a long tradition in health care literature, and may particularly document the holism, inclusivity, uniqueness, and complexity of OT practice.

Objective: To determine how case studies make a distinct contribution to professional knowledge, using a new model for categorizing them.

Evidence Review: 103 case studies published in AJOT from 1990-2023 were rated by the authors “1” or …

Translating Knowledge Of Functional Cognition Into Occupational Therapy Practice, Mckenzie R. Behrendt, Emilea Rogers, Azia Ourada, Sara Mengler, Mackenzie Post, Stacy Smallfield

Translational Science in Occupation

Functional cognition is a critical component for safely and effectively performing daily occupations. Occupational therapy (OT) practitioners are uniquely positioned and trained to address functional cognition while considering a client’s abilities and environments. A multimedia e-learning module was developed as a teaching modality to enhance understanding and application of functional cognition concepts for OT students and practitioners. As educators, it is important to assess the effectiveness of the teaching and learning experiences we create. We evaluated the multimedia e-learning module for quality, value, and usefulness using critical reflection perspectives. These perspectives included a literature review, as well as from learner, …

Gazing In The Mirror: Reflecting On Student Perspectives In Work-Integrated Learning In Healthcare Education, Cassidy P. Johnson, Simone C. Regnier, Leah M. Stade Otd, Mhptt, Otr/L

Translational Science in Occupation

Abstract: Student engagement is typically woven into the curriculum of healthcare education through hands-on experiences, lectures, discussions, active learning, and lab components. This engagement is critical to developing student confidence, efficacy, and esteem in important skills that will serve them as they enter their profession. In our doctoral program, we are allowed additional engagement opportunities, including belonging to a research project with professionals. Upon reflection, our experience on an interprofessional research team has helped to translate our classroom knowledge to research and professional practice skills.

Plain-Language Summary: This paper is a reflection on the value of adding work skills beyond …

Retrospective Chart Review Of The Acute Care Psychosocial Evaluation Process For Females Diagnosed With Breast Cancer, Kimberly Conrad, Lou Jensen, Shelley Ashcroft, Antoine Bailliard, Vanessa D. Jewell

Translational Science in Occupation

Background: A breast cancer diagnosis can significantly impact an individual’s quality of life. This retrospective chart review explored the occupational therapy evaluation process with female patients in an inpatient acute care hospital with a breast cancer diagnosis.

Methods: This descriptive retrospective chart review analyzed 134 occupational therapy evaluations of female patients with breast cancer admitted to a southeastern US academic medical center. Data were extracted and categorized using the Occupational Therapy Practice Framework.

Results: The most frequently administered assessments were non-standardized and the AM-PAC "6-Clicks." Documented short-term goals primarily focused on self-care (56.6%), gross motor skills (24.7%), and instrumental activities …

Exploration Of Learning Preferences For Parents Of Children With Sensory Over-Responsivity: A Mixed-Methods Study, Lisa M. Porter, Shelly J. Lane, Barbara B. Demchick, Jane K. Sweeney, Breanne Kearney

Translational Science in Occupation

Importance: Parent education is essential to pediatric occupational therapy (OT), yet there is a paucity of research regarding how to best support parents as adult learners.

Objective: To explore the learning experiences of parents of children with sensory over-responsivity (SOR).

Methods: An embedded mixed-methods design was used. Sixteen parents of children with SOR, aged 3–8 years, were recruited using purposive sampling. All parents participated in group trainings; of these, nine participated in one-on-one interviews. Quantitative data included pre-intervention parenting self-efficacy (PSE) scores and post-intervention learner satisfaction measures. Semi-structured interviews were used to explore parents’ learning experiences during …

Perceptions And Barriers Of Vestibular Rehabilitation Among Occupational Therapy Practitioners, Rebecca Callais

Translational Science in Occupation

Background: Vestibular dysfunction affects 15-20% of adults annually, often impacting daily activities and quality of life (Neuhauser, 2016). While occupational therapists and occupational therapy assistants (OTs/OTAs) can address functional limitations caused by vestibular disorders, their role in vestibular rehabilitation (VR) is under-studied.

Objective: This study explored the competence and confidence of occupational therapy practitioners (OTP) in VR and identified barriers to implementation.

Methods: A cross-sectional survey was distributed to 532 OTP in the Gulf South region, with 79 responses received. The survey included questions on VR training, techniques used, barriers of implementation in practice, and educational supports. Quantitative data were …

Integration Of The Science Of Team Science (Scits) With Applied Healthcare Frameworks: Interprofessional Education Through A University-Based Head Injury Clinic, Part I: Theory, Emily Balog, Susan Paparella, Natalia Noce, Stephanie Hubbell, Kelly Pena

Translational Science in Occupation

Background: Wicked problems in healthcare, such as the complex health condition of head injury, demand interprofessional collaboration that transcends traditional disciplinary boundaries. These complex clinical challenges call for theoretical frameworks that integrate both disciplinary expertise and interdisciplinary processes.

Definitions and Concepts: Grounded in Repko and Szostak’s (2017) framework of interdisciplinary studies, this paper integrates the Science of Team Science (SciTS), the Interprofessional Education Collaborative (IPEC) competencies, and TeamSTEPPS® to construct a novel heuristic that informs the design of an interprofessional education (IPE) and practice model.

Relationships Between Concepts: We align SciTS’ four phases with IPEC and TeamSTEPPS® to enhance team-based …

Cooperative Role Of Distinctive Tp53 And Pten Combined Loss In The Peripheral T Cell Lymphoma-Gata3 Molecular Subgroup, Waseem G. Lone, Jiayu Yu, Xuxiang Liu, Dylan T. Jochum, Alyssa Bouska, Kunal Shetty, Tyler Herek, Sunandini Sharma, Chengfeng Bi, Rauf Shah, Zaina W. Nasser, Catalina Amador, Aiza Arif, Abdul Rouf Mir, Yuping Li, Tayla B. Heavican-Foral, Jacob Robinson, R. Katherine Hyde, Mamiko Sakata-Yanagimoto, Satyanarayana Rachagani, Timothy W. Mckeithan, David W. Scott, Louis M. Staudt, Giorgio Inghirami, Andrew Feldman, Timothy Greiner, Julie M. Vose, Lisa Rimsza, Joseph Khoury, Wing C. Chan, Javeed Iqbal, Lymphoma/Leukemia Molecular Profiling Project (Llmpp)

Journal Articles: Oncology and Hematology

Peripheral T cell lymphoma (PTCL) is a heterogeneous group of postthymic T cell neoplasms, with ~40% classified as PTCL-not otherwise specified (PTCL-NOS). PTCL-GATA3, a molecularly defined subtype, associated with T helper 2 (T_H2)-like differentiation and poor prognosis, has frequent co-occurrence of TP53 loss/mutation and heterozygous PTEN loss. CD4+ T cell conditional mouse models with Trp53 mutation/deletion and Pten loss demonstrated mature T cell lymphomas (mTCLs) with T_H2-like transcriptomic and immunophenotypic profiles. Molecular studies revealed that codeletion of Trp53/Pten induced T cell receptor and Janus kinase-signal transducer and activator of transcription signaling, promoting T_H2 differentiation …

Integrative Genomic And Transcriptomic Analysis Reveals Targetable Vulnerabilities In Angioimmunoblastic T-Cell Lymphoma, Alyssa Bouska, Weiwei Zhang, Sunandini Sharma, Harald Holte, Rauf Shah, Waseem G. Lone, Mahfuza Afroz Soma, Ruimeng Yang, Xuxiang Liu, Syed Mehmood, Ravneet Singh Chawla, Luca Vincenzo Cappelli, Danilo Fiore, Qiang Gong, Tayla B. Heavican-Foral, Jeffrey J. Cannatella, Catalina Amador, Aiza Arif, Lynette M. Smith, Soon Thye Lim, Choon Kiat Ong, Andrew L. Feldman, Ming-Qing Du, Anamarija M. Perry, Laurence De Leval, Timothy C. Greiner, Kai Fu, Gunhild Trøen, Daniel Vodák, Sigve Nakken, Jan Delabie, David Weinstock, Stefano Pileri, Antonella Laginestra, Kyeongjin Kim, Utpal Pajvani, Julie M. Vose, Dennis D. Weisenburger, Steven M. Horwitz, Sandeep Dave, Joseph Khoury, Giorgio Inghirami, Wing C. Chan, Javeed Iqbal

Journal Articles: Oncology and Hematology

Nodal follicular helper T-cell (T_FH) lymphoma of the angioimmunoblastic (AITL) subtype has a dismal prognosis. Using whole-exome sequencing (n = 124), transcriptomic (n = 78), and methylation (n = 40) analysis, we identified recurrent mutations in known epigenetic drivers (TET2, DNMT3A, IDH2^R172) and novel ones (TET3, KMT2D). TET2, IDH2^R172, DNMT3A co-mutated AITLs had poor prognosis (p < 0.0001). Genes regulating T-cell receptor (TCR) signaling (CD28, PLCG1, VAV1, FYN) or activation (RHOA^G17V) or regulators of the PI3K-pathway (PIK(3)C members, PTEN, PHLPP1, PHLPP2) were mutated. CD28 mutation/fusion was associated with poor prognosis (p = 0.02). WES of purified, neoplastic T-cell (CD3⁺PD1⁺) demonstrated high concordance with …

Association Between Rurality And Race/Ethnicity And Pediatric Cancer Early Mortality: A Population-Based Cohort Study Using Seer Data From 2000 To 2021, Kiersten Preuss, Emma Hymel, Melissa Acquazzino, Shinobu Watanabe-Galloway

Journal Articles: Epidemiology

BACKGROUND: Pediatric cancer mortality rates have steadily declined since 2009, but over a thousand deaths still occur annually. While existing research highlights the effects of race/ethnicity and rurality on overall survival, few studies have specifically analyzed these factors in relation to early mortality, defined as death within 12 months of diagnosis.

PROCEDURE: This study utilized SEER Research Plus Limited-Field Data (2000-2021) to examine the association between race/ethnicity, rurality, and early mortality in pediatric cancer patients. A cohort of 138,648 individuals was analyzed using Cox proportional hazards regression models to calculate hazard ratios and 95% confidence intervals (CIs).

RESULTS: The results …