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Articles 1 - 30 of 110
Full-Text Articles in Medicine and Health Sciences
The Impact Of Hospital Change Of Ownership On Hospital Quality Of Care As Evidenced By Patient Satisfaction Scores And Readmission Rates, Ian Edward Mcfadden
The Impact Of Hospital Change Of Ownership On Hospital Quality Of Care As Evidenced By Patient Satisfaction Scores And Readmission Rates, Ian Edward Mcfadden
All ETDs from UAB
THE IMPACT OF HOSPITAL CHANGE OF OWNERSHIP ON HOSPITAL QUALITY OF CARE AS EVIDENCED BY PATIENT SATISFACTION SCORES AND READMISSION RATES IAN E. MCFADDEN DOCTOR OF SCIENCE IN ADMINISTRATION-HEALTH SERVICES ABSTRACT Much of the literature on current hospital consolidation activity reveals that hospitals and health systems are experiencing an inordinate amount of increased merger and acquisition activity due to the impact of healthcare reform legislation. The implementation of the Affordable Care Act of 2010 resulted in many hospital and health system providers seeking consolidation as a means to enhance resources and capital. These efforts have resulted in many hospitals changing …
Membrane Capacitance Derived From Bioimpedance Spectroscopy Is Associated With Insulin Resistance In Relatively Healthy U.S. Women, But Not Men, Valene Garr Barry
Membrane Capacitance Derived From Bioimpedance Spectroscopy Is Associated With Insulin Resistance In Relatively Healthy U.S. Women, But Not Men, Valene Garr Barry
All ETDs from UAB
Current screening methods have failed to detect more than 50% of the 120 million U.S. adults with insulin resistance and/or metabolic syndrome, conditions that substantially increase one’s risk for cardiometabolic disease (CMD).1 Evidence exists that metabolic health is associated with cell membrane composition, which is reflected in the electrical properties of the body cell mass. The objective of this study was to determine whether bioimpedance spectroscopy can identify insulin resistance and/or metabolic syndrome by evaluating membrane capacitance (CM). We hypothesized that CM would be higher in individuals with insulin resistance and/or metabolic syndrome when compared to healthy individuals. This cross-sectional …
Interorganizational Relationships And Hospital Adoption Of Surgical Robots, Stephen Cullen
Interorganizational Relationships And Hospital Adoption Of Surgical Robots, Stephen Cullen
All ETDs from UAB
INTERORGANIZATIONAL RELATIONSHIPS AND HOSPITAL ADOPTION OF SURGICAL ROBOTS STEPHEN G. CULLEN EXECUTIVE DOCTORIAL PROGRAM IN HEALTHCARE LEADERSHIP ABSTRACT The study investigates the relationship between interorganizational relationships (IORs) and hospital adoption of robotic surgery in the United States over a ten-year period. As a competitive strategy for hospitals, IORs should matter in a hospital’s decision to adopt a surgical robot given associated costs and risks. While literature exists on IORs and technical innovation, there is a gap in the literature on IORs and hospital adoption of surgical robots. This study explores four types of IORs (i.e., networks, systems, contract management, and …
Cheminformatic Discovery And Characterization Of Copperdependent Bacterial Inhibitors, Alex Dalecki
Cheminformatic Discovery And Characterization Of Copperdependent Bacterial Inhibitors, Alex Dalecki
All ETDs from UAB
Deaths due to antibiotic-resistant bacteria are predicted to exceed 10 million per year by 2050, endangering our ability to conduct fundamental medical procedures such as immunosuppressive therapy or even basic surgery. Unfortunately, we are largely falling behind in the evolutionary arms race against common pathogens. Not only are we in sore need of new antibiotics, we also evidently need altogether new approaches to drug discovery itself, as our familiar avenues are increasingly failing to meet demands. In this dissertation, we describe a promising new source of antibacterials: copper-dependent inhibitors (CDIs), compounds that exert significant antibiotic activity only in the presence …
Effects Of Dietary R,S-1,3 Butanediol Diacetoacetate On Components Of Energy Balance, Rachel A H Davis
Effects Of Dietary R,S-1,3 Butanediol Diacetoacetate On Components Of Energy Balance, Rachel A H Davis
All ETDs from UAB
Ketogenic diet (KD) has been used to attenuate the decline in energy expenditure occurring from calorie restriction-induced weight loss, but long-term adherence can be difficult due to the strict nature of the diet. The growing body of evidence supporting KD-treatment of neurologic and metabolic diseases, as well as obesity, has prompted interest in the ability to increase circulating ketones via exogenous delivery. Ketone esters (KE) can raise blood ketone concentrations similarly to fasting and appear to reduce food intake acutely, but studies assessing effects on energy balance are limited and provide a potentially promising direction for weight control. Previous investigations …
Constraint-Induced Movement Therapy To Improve Gait And Mobility Of People With Chronic Stroke: A Mixed Methods Study, Sarah Monteiro Dos Anjos
Constraint-Induced Movement Therapy To Improve Gait And Mobility Of People With Chronic Stroke: A Mixed Methods Study, Sarah Monteiro Dos Anjos
All ETDs from UAB
Walking impairment after stroke impacts on participation and quality of life. Different techniques have been developed in the last decades to overcome walking difficulties after stroke, however, few have been shown to be efficacious. Constraint-induced Movement Therapy (CIMT) is a family of techniques that has been reported as one the most effective intervention for improving functional use and motor skills of a more-affected upper extremity (UE). The intervention protocol includes: 1) intensive supervised training; 2) use of shaping as a strategy for the motor training, 3) a group of behavioral strategies called the transfer package, and 4) procedures to increase …
The Effects Of Body Size, Growth, And History Of Diabetes On Glioma Risk, Rebecca Barnhill Little
The Effects Of Body Size, Growth, And History Of Diabetes On Glioma Risk, Rebecca Barnhill Little
All ETDs from UAB
Many dietary exposures have weak or null associations with glioma risk. As nutrition can affect growth rate in adolescence, body size throughout the lifespan, and the propensity for Type 2 diabetes, the goal of this project was to examine the relationships between these surrogates of nutritional states and the risk of glioma. The aims of this project were to examine the associations between glioma risk and 1) self-reported body measures; 2) age when full height was attained; 3) and a history of diabetes. To investigate the first aim, 1,111 glioma cases and 1,096 community controls completed a structured interview to …
Elucidating The Role Of Hedgehog Signaling In Modulating Macrophage Function In Breast Cancer, Ann Hanna
Elucidating The Role Of Hedgehog Signaling In Modulating Macrophage Function In Breast Cancer, Ann Hanna
All ETDs from UAB
In the tumor microenvironment, breast cancer cells participate in crosstalk with the surrounding stroma. This tumoral-stromal interaction forms a balance that dictates tumor suppressing or tumor promoting response mechanisms. Macrophages in the tumor microenvironment are plastic and can mediate several functions depending on their activation states. Tumor associated macrophages co-exist as two major phenotypes: anti-tumorigenic and immune-eliciting classically activated M1 as well as tumor-promoting and immune-suppressive alternatively activated M2 macrophages. Alternatively activated macrophages are specifically associated with more aggressive stages and poor clinical outcomes in breast cancer patients as they suppress the tumoricidal properties of the immune system, thus facilitating …
Assessment Of Head Asymmetry In Prematurely Born Children During Early Childhood Using 3d Photography, Panagiotis Kyteas
Assessment Of Head Asymmetry In Prematurely Born Children During Early Childhood Using 3d Photography, Panagiotis Kyteas
All ETDs from UAB
The aim of this study is to assess the course of plagiocephaly during early childhood in preterm and fullterm children and determine any differences throughout the given timeframe between the two groups. Materials and Methods: 34 preterm and 34 fullterm children born in the Oulu University Hospital, Finland attended the clinical study at the age of 3 (T1), 6 (T2), (T3) months and 3 years (T4). At each visit, 3D images of the head were obtained using a 3dMD head 5-pod camera system (3dMD, Atlanta, GA). Nine outcome variables including 2D and 3D measurements were calculated. Results: At T1, 26.47% …
Endodontic Post Retention With Resin Cements (Ilumi Fiber Post), Faimeena Farheen
Endodontic Post Retention With Resin Cements (Ilumi Fiber Post), Faimeena Farheen
All ETDs from UAB
Objectives: Loss of post retention is the leading cause in the cemented post. There is no good method of bonding a fiber post in a post space with resin cements because adhesive cementation into a prepared post space is difficult- due to an inability to place, dry and light cure the adhesive and the cement. A new post system (iLumi) that transmits light to the apex of the post has recently been developed. We want to know if this system will improve post retention in each section (coronal, middle and apical) of the prepared post space and if this curing …
Simulation Of Correlated Variables, Mixture Distributions, And Repeated Measures And Comparison Of Pharmacogenetic Prediction With Machine Learning Methods, Allison Cynthia Fialkowski
Simulation Of Correlated Variables, Mixture Distributions, And Repeated Measures And Comparison Of Pharmacogenetic Prediction With Machine Learning Methods, Allison Cynthia Fialkowski
All ETDs from UAB
Pharmacogenetics aims to improve individualized medicine by combining genetic information with clinical data when assigning drug treatments. Different diseases are often associated with different factors, each with its own distributional characteristics. For rare or complex diseases, these characteristics may not be well understood and standard analysis methods may not be appropriate. In psychiatric disorders, for example, multiple drug treatments need to be compared across small sample sizes with heterogeneous patient populations, making implementation of standard methods difficult. Simulating data that mirrors clinical data is important because it allows investigators to determine which method is best suited for data from their …
The Role Of Astrocytes In The Development Of Central Chemosensitivity, Kelsey Patterson
The Role Of Astrocytes In The Development Of Central Chemosensitivity, Kelsey Patterson
All ETDs from UAB
In the two decades since MECP2 was identified as the causative gene in the majority of Rett Syndrome (RTT) cases, transgenic mouse models have played a critical role in our understanding of this X-linked neurodevelopmental disease. However, their exclusive use presents a limitation in translating findings from animal models to the clinic. Here, we characterized growth, anatomical, behavioral, and motor deficits in a novel zinc-finger nuclease murine RTT model from birth through adulthood. Male rats lacking the transcriptional regulatory protein, MeCP2 (Mecp2ZFN/y), are noticeably symptomatic as early as postnatal day (P) 21 and die prematurely, while females lacking one copy …
Pharmacological Inhibition Of Thioredoxin-Interacting Protein To Protect Against Diabetes, Lance Thielen
Pharmacological Inhibition Of Thioredoxin-Interacting Protein To Protect Against Diabetes, Lance Thielen
All ETDs from UAB
The loss of functional beta cell mass represents a major factor in the pathogenesis of type 1 and type 2 diabetes. Inadequate production of insulin, a glucose-lowering hormone, and elevated glucagon production, a gluconeogenic hormone, contribute to impaired glycemic control and hyperglycemia. This promotes a vicious cycle involving glucotoxicity and additional beta cell dysfunction. Currently there are no therapies that halt this process; however, thioredoxin-interacting protein (TXNIP) has recently emerged as a promising therapeutic target. TXNIP was found to be the top glucose-induced gene in a human pancreatic islet microarray, is increased in mouse models of diabetes and diabetic human …
Novel Insights Into Neurofibromin Function And Human Neurofibromatosis Type 1 Mutations Using Genetically Engineered Mouse Models, Ashley Nicole Turner
Novel Insights Into Neurofibromin Function And Human Neurofibromatosis Type 1 Mutations Using Genetically Engineered Mouse Models, Ashley Nicole Turner
All ETDs from UAB
Loss of NF1 in different developmental and cellular contexts leads to unique physiological outcomes due to loss of neurofibromin function, including embryonic lethality, sporadic cancers, and the genetic disorder NF1. Neurofibromin acts as a tumor suppressor by modulation of RAS signaling, with other functions of this multi-domain protein being less clear. Even within the monogenic disorder of NF1, the clinical heterogeneity and mutational spectrum are immense, revealing the complexity underlying this disorder. There is a huge urgency and need for NF1 therapeutic treatments, and the same urgency to develop in vivo models to better understand NF1 that can be utilized …
Synaptic Mechanisms Underlying The Integration Of Adult-Generated Neurons In The Dentate Gyrus, Ryan Vaden
Synaptic Mechanisms Underlying The Integration Of Adult-Generated Neurons In The Dentate Gyrus, Ryan Vaden
All ETDs from UAB
The dentate gyrus is a region in the adult brain where new neurons continue to be generated throughout life. While most adult-generated neurons undergo apoptosis within the first few weeks of maturation, a fraction survives and integrates into the existing circuit. It is well established that γ-aminobutyric acid (GABA) receptor-mediated mechanisms contribute to the activity-dependent regulation of adult-neurogenesis. GABAergic interneurons regulate stem cell quiescence, progenitor proliferation, and the synaptic integration of newborn neurons, however the synaptic interactions underlying integration are not fully understood. Furthermore, the impact of adult-generated neurons integrating into the existing circuit is not completely known. The collective …
Clinical And Histomorphometric Outcomes Following The Use Of Small Versus Large Particle Sized Bone Allografts In Ridge Preservation Procedures: A Randomized Clinical Trial, Gentiane Valiquette
Clinical And Histomorphometric Outcomes Following The Use Of Small Versus Large Particle Sized Bone Allografts In Ridge Preservation Procedures: A Randomized Clinical Trial, Gentiane Valiquette
All ETDs from UAB
Alveolar ridge preservation at the time of tooth extraction is a commonly performed procedure as it significantly minimizes ridge resorption and allows for more optimal implant placement. The amount of new vital bone has been shown to vary with the use of different types of bone replacement grafts, however, the effect of bone graft particle size on the outcomes following ridge preservation has not been elucidated in the scientific literature. The present randomized clinical trial compared clinically, radiographically and histomorphometrically the use of small- (0.25-1.0mm) versus large- (1.0- 2.0mm) sized particle mineralized cortico-cancellous bone freeze-dried bone allografts (FDBAs) in ridge …
Assessing Barriers And Facilitators To Appropriate Care For Chronic Pain And Prescription Opioid Abuse, Allyson Varley
Assessing Barriers And Facilitators To Appropriate Care For Chronic Pain And Prescription Opioid Abuse, Allyson Varley
All ETDs from UAB
The objective of this study was to understand and assess barriers and facilitators to the uptake of appropriate care for co-occurring chronic noncancer pain (CNCP) and opioid use disorder. Rates of CNCP and opioid overdose have doubled in the past decade. When a patient transitions from appropriate use to misuse, significant changes must be made to their treatment plan. Considering most CNCP is treated with opioids in the primary care setting, primary care providers (PCPs) are potential change agents to remediate the epidemic of opioid abuse. Although studies have explored opioid stewardship, we still lack an understanding of the factors …
Molecular Characterization Of The Rare Cftr Mutation P67l As A Model For Genotype-Specific Drug Development And Personalized Medicine In Cystic Fibrosis, Carleen Mae Pomperada Sabusap
Molecular Characterization Of The Rare Cftr Mutation P67l As A Model For Genotype-Specific Drug Development And Personalized Medicine In Cystic Fibrosis, Carleen Mae Pomperada Sabusap
All ETDs from UAB
The traditional CFTR functional defect subcategories (i.e. protein misfolding, gating, conductance, etc.) are sometimes inadequate for determining patients most likely to benefit from emerging modulator treatment. We employ the P67L variant as emblematic of ways a thorough biochemical analysis of a rare CF defect can guide new therapeutic approaches, help predict drug response, and facilitate clinical precision. Historically, P67L has been designated a class IV conductance abnormality (i.e., malformed ion pore). In contrast, our studies demonstrate P67L disrupts CFTR protein maturation, prompts misfolding, causes gating defects, and exhibits wild-type like conductance. We show that P67L CFTR is robustly rescued by …
Epigenetic Regulation Of Stem Cell Fate Determination And Tumorigenesis, Kushani Shah
Epigenetic Regulation Of Stem Cell Fate Determination And Tumorigenesis, Kushani Shah
All ETDs from UAB
It is unclear how H3K4 methylation, an epigenetic modification associated with gene activation, regulates stem cell fate determination and tumorigenesis. DPY30 is one of the core subunits of the SET1/MLL complex in mammals responsible for H3K4me. DPY30 enhances the H3K4me activity of the SET1/MLL complex. Here, I sought to define role of DPY30 and H3K4me3 in postnatal neurogenesis and hematopoietic malignancies. Using a conditional knockout model, I found that Dpy30 deficiency halts the development of postnatal hippocampus, the subventricular zone, and cerebellum. Deficiency in cerebellum is most likely the cause of uncoordinated ataxia-like movements in these mice. By deleting Dpy30 …
Social Factors, Public Policies, And Infant Mortality, Lauren Wallace
Social Factors, Public Policies, And Infant Mortality, Lauren Wallace
All ETDs from UAB
Despite consistent and substantial investments, the United States’ infant mortality rate (IMR) has not decreased significantly in the 21st century and disparities between racial and ethnic groups have increased. This study investigates the impact of social and health factors, and public policies on IMR at the state level. The research aims were to: 1) evaluate which state-level social factors and public policies were associated with state IMRs using principal component (PC) analysis; and 2) evaluate whether states cluster on their PC scores and IMRs using cluster analysis. The data used were six composite index scores based on social factor and …
Assessment Of A Peer Mentoring Program At Lawson State Community College, Teneasha Washington
Assessment Of A Peer Mentoring Program At Lawson State Community College, Teneasha Washington
All ETDs from UAB
ABSTRACT Colleges and universities have begun implementing mentoring programs to offset rising attrition rates; however, the literature on the benefits of these programs is limited particularly among community colleges with peer mentoring programs serving minority students. Further limiting our understanding of post-secondary peer mentoring programs is the lack of research on mentor’s as well as mentee’s perspectives on the mentoring experience. As mentors and mentees serve in a variety of capacities within the mentoring program, it is often difficult to identify outcomes that can be assessed within the mentoring program. Although the success of peer mentoring programs is directly affected …
Nf-Κb And Methyl-Lysine Signaling In The Epigenetic Regulation Of Memory, William Mitchell Webb
Nf-Κb And Methyl-Lysine Signaling In The Epigenetic Regulation Of Memory, William Mitchell Webb
All ETDs from UAB
Epigenetic mechanisms such as DNA methylation and histone methylation are critical regulators of gene transcription during memory consolidation and retrieval. However, the means by which these mechanisms are themselves initiated and directed to specific gene regions, and the extent to which these marks coordinate control of gene expression, remain poorly understood. In this dissertation, we explore the role of methyl-lysine signaling in the epigenetic regulation of gene expression in two contexts. First, we investigated the role of histone H3 lysine 4 tri-methylation (H3K4me3) and DNA 5-hydroxymethylation (5hmC) during memory retrieval, finding that these marks increased globally and at CpG-enriched coding …
Connecting Cilium Proteins Bbs5 And Mks6 And Their Roles In Retinal Degeneration, Katie Leigh Bales
Connecting Cilium Proteins Bbs5 And Mks6 And Their Roles In Retinal Degeneration, Katie Leigh Bales
All ETDs from UAB
The primary cilium is an evolutionary conserved structure with numerous motility and sensory-related functions, dynamically concentrating signaling molecules to developmental, homeostatic and sensory pathways. Rod and cone photoreceptor cells are highly modified primary cilia, which reside in the back of the eye within the neural retina and are responsible for dim light sensitivity and visual acuity/ color vision, respectfully. These cells require massive protein production and proper protein trafficking on a daily basis. The major protein complexes that govern protein trafficking within photoreceptors form the connecting cilium, are the transition zone which serves as a gatekeeper, regulating protein trafficking into …
Effects Of Medicaid Expansion On The Financial Performance Of Rural Hospitals, Keith Darryl Brady
Effects Of Medicaid Expansion On The Financial Performance Of Rural Hospitals, Keith Darryl Brady
All ETDs from UAB
EFFECTS OF MEDICAID EXPANSION ON THE FINANCIAL PERFORMANCE OF RURAL HOSPITALS KEITH BRADY DOCTOR OF SCIENCE IN HEALTH SERVICES ADMINISTRATION ABSTRACT The purpose of this research was to examine the effects of Medicaid expansion on the financial performance of rural hospitals. The analysis compares Medicaid revenue, uncompensated care cost and operating margins between rural hospitals in states that expanded Medicaid and rural hospitals in states that did not expand Medicaid. Strategic Management Theory was used to develop a theoretical framework to address three primary hypotheses. Secondary data from the Medicare Cost Report (MCR), the Agency for Healthcare Research and Quality …
Gender-Specific Facilitators And Barriers To Health-Related Quality Of Life In Adults With Cystic Fibrosis: A Mixed Methods Study, Leigh Ann Bray
Gender-Specific Facilitators And Barriers To Health-Related Quality Of Life In Adults With Cystic Fibrosis: A Mixed Methods Study, Leigh Ann Bray
All ETDs from UAB
BACKGROUND: With the life expectancy of individuals with cystic fibrosis (CF) doubling over the last two decades, it is critical that healthcare providers address both quantity and quality of life. Health-related quality of life (HRQoL) encompasses physical, social, psychological, and functional aspects of daily living and how CF impacts each one. Women with CF consistently report having an overall poorer quality of life across international studies, but the cause of the gender difference is unknown. The purpose of this study was to explore gender differences in HRQoL and then build upon those results to better understand gender-specific facilitators and barriers …
The Effect Of Primary Palatal Repair On Growth In Cleft Lip And Palate Patients, Nadia Abou Kheir
The Effect Of Primary Palatal Repair On Growth In Cleft Lip And Palate Patients, Nadia Abou Kheir
All ETDs from UAB
Cleft lip and palate (CLP) is a facial defect that is represented as a split in the mouth, palate or both. In the United States approximately 4440 babies are born with CLP annually. More than US$600 million are spent on their treatment and mostly on surgical interventions. Considering the high expenses of primary palatal repair, its effect on growth has been controversial. Surgical scaring is postulated as the cause of maxillary hypoplasia. However, this operation has been considered necessary for function and development of speechHowever, this operation has been considered as necessary for better functional and speech outcomes. Materials and …
Vestibular And Oculomotor Function In Children With Cerebral Palsy, Anwar B. Almutairi
Vestibular And Oculomotor Function In Children With Cerebral Palsy, Anwar B. Almutairi
All ETDs from UAB
Cerebral palsy (CP) is the most common motor disability of childhood, caused by non-progressive permanent injury to the fetal or infant’s brain. Visual and balance impairments are prominent hallmarks of these disorders. Although musculoskeletal and neuromuscular causes are well established in the literature, the role of vestibular and oculomotor disabilities was not explored in this population. Because of that, this dissertation aims to describe the vestibular and oculomotor function in children with CP, aged 7-12years, GMFCS levels I-III, and to determine the feasibility, sensitivity, specificity and retest reliability of vestibular and oculomotor clinical tests in children with CP, compared to …
Parental Decision-Making In Use Of Complementary And Alternative Medicine, Meka B. Astin
Parental Decision-Making In Use Of Complementary And Alternative Medicine, Meka B. Astin
All ETDs from UAB
One health care trend is the growing public interest in, and use of, complementary and alternative medicine (CAM). Research in the United States suggests that significant numbers of children are involved in various forms of alternative medicine. The purpose of this dissertation is to assess the predictors of parental decision-making of CAM use for their child using five categories of CAM therapies: alternative medical systems, biologically- based, mind-body, manipulative, and a separate and distinct category to include all CAM medical systems. Andersen’s health care Utilization Model (HUM), which holds that health service use is a function of predisposing, enabling, needs …
Diet, Physical Activity, And Healthy Aging In People Living With Hiv, Josh Newson Muhammad
Diet, Physical Activity, And Healthy Aging In People Living With Hiv, Josh Newson Muhammad
All ETDs from UAB
As life expectancy for people living with HIV (PLWH) has increased, healthy aging in this community has become an emerging public health concern. Although the benefits of adopting healthy diets and regular physical activity are well-documented, implementing strategies for lifestyle modifications among older PLWH remains a challenge. The complex milieu of social, physiological and economic burdens encountered by PLWH exposes this population to increased risk for adverse health outcomes, especially from preventable metabolic diseases. The interaction of diet, physical activity and social determinants of health in persons who are HIV positive is an understudied area. The aim of this dissertation …
Culture And Patient Safety Outcomes: Examining The Impact Of The Departmental Work Environment On Outcomes, Dawn Ahner
Culture And Patient Safety Outcomes: Examining The Impact Of The Departmental Work Environment On Outcomes, Dawn Ahner
All ETDs from UAB
This study examined the relationship between the departmental work environment and patient safety outcomes to determine if there were particular subcomponents of a department’s work environment that had a more significant impact on patient safety outcomes. The work environment was defined as the culture of an individual nursing department which consisted of the employee’s perception of engagement and patient safety culture. The research was informed by the commitment-based theory. Based on this theory, it was predicted that a team-based approach in the work environment would lead to a learning and positive environment, which would be positively associated with quality of …