Medicine and Health Sciences Commons^™

The Great Pestilence: Yellow Fever In Portsmouth, Virginia, 1855, Burden Susan Lundgren

Health Services Research Dissertations

In 1855, the town of Portsmouth, Virginia was devastated by an epidemic of yellow fever. Most citizens fled. Of those who remained, most became infected and a thousand died. The municipal government collapsed. In their place, a small organization known as the Portsmouth Relief Association assumed responsibility for ensuring the survival of the town. This organization managed the care of the sick, the burial of the dead, and the care of orphans. It was the sole agent receiving and allocating the funds and resources that poured into the community. Scarce food, drugs and other supplies were available only through the …

The Antitumor Agent, Arglabin-Dma, Preferentially Induces Apoptosis In Human Colon Tumor Cells, Sung Wook Kwon

Theses and Dissertations in Biomedical Sciences

Arglabin-DMA, an analog of farnesyl pyrophosphate (FPP), reportedly inhibits farnesyltransferase (FTase) directly by competitively blocking the binding of Ras protein and its posttranslational modification, as suggested in previous studies. But, the mechanisms by which Arglabin-DMA inhibits tumor growth in vivo and in vitro are still relatively poorly characterized. To determine the mechanism by which this drug inhibits tumor growth, the effects of Arglabin-DMA in two human colon tumor cell lines (mutant K-ras HCT 116 and wild-type ras HT-29) were explored on cell proliferation, apoptosis, and cell cycle kinetics in vitro. In cell viability studies, we showed that Arglabin-DMA …

Predictors Of Student Success In An Entry-Level Baccalaureate Dental Hygiene Program, Mohammad J. Alzahrani

Dental Hygiene Theses & Dissertations

The purpose of this study was to measure the utility of a variety of predictors that have been used by the Old Dominion University, Gene W. Hirschfeld School of Dental Hygiene and other baccalaureate dental hygiene programs in selecting dental hygiene students who are most likely to graduate and be successful in passing the National Board Dental Hygiene Examination (NBDHE). Specifically this study attempted to determine whether or not the following factors are reliable predictors of success in a an entry-level baccalaureate dental hygiene program as evidenced by graduation and successful entry into the profession as evidenced by passing the …

Downward Comparison As An Intervention To Lower Self-Reported Risk-Taking Behaviors, John P. Barile

Psychology Theses & Dissertations

This research investigated the utility of using first-person editorial-style stories as a means to lower the occurrence of self-reported risk-taking behaviors such as drunk driving and red-light running in undergraduate college students. This study assessed the frequency of risk-taking behaviors of college students before and after a three-week online intervention. Students were randomized into one of three conditions. Two risk taking treatment groups read and rated stories about a college student that had suffered a severe consequence from either drunk driving or red-light running. A third group received non-driving college stories that involved no health risk. The stories were presented …

A Family Systems Approach To Substance Misuse: An Examination Of Risk And Protective Factors, Jennifer Anne Cutchin

Psychology Theses & Dissertations

This purpose of this project was to investigate the interrelationships between family structure, classroom stress, sense of belonging, and substance misuse in college students. Some outcomes of the study were an increased knowledge of substance misuse in college students and the impact of risk and protective factors on substance misuse. One model of family structure is the Circumplex Model of Family Systems. This model consists of three components: family cohesion, adaptability and communication fOIson, Russell, & Sprenkle, 1989). This research was conducted at Old Dominion University using 391 undergraduate college students, aged 18 - 25. It was hypothesized that students …

Mechanisms Of Cell Death Initiated In Herpes Simplex Virus Thymidine Kinase Expressing Colon Tumor Cells Treated With Ganciclovir And Ucn-01, Christina Elizabeth Ahn

Theses and Dissertations in Biomedical Sciences

Metastatic colon carcinoma is the second leading cause of death from malignancy in the United States, and development of more effective treatments is essential. Heterologous expression of Herpes Simplex Virus Thymidine Kinase (HSVtk) in combination with the prodrug, ganciclovir (GCV), has shown great promise for the genetic therapy of many cancers, but most patients have had only a partial or minimal response to the therapy. After screening a panel of two drug combinations, our laboratory has shown that the combination of GCV and the protein kinase inhibitor UCN-01 (7-hydroxystaurosporine) enhances tumor cell death more effectively than either drug alone. However …

Survey Of Camera Phone Awareness In Outpatient Community Behavioral Health Facilities, Tara Lynn Overton

Community & Environmental Health Theses & Dissertations

The purpose of this study was to determine the level of camera phone awareness in outpatient community behavioral health facilities in a medium sized Mid-Atlantic state. Camera phones have been shown to have a detrimental effect on the protection of privacy in areas such as corporations, gym locker rooms, and court houses, but privacy issues have not yet been addressed in behavioral health. Privacy is an important issue in healthcare as shown through the implementation of the Health Insurance Portability and Accountability Act (HIPAA). This study used Rogers' (1995) Diftbsion of Innovations Theory as a framework for determining the stage …

Dietary Supplements And Sports Performance: Amino Acids, Melvin H. Williams

Human Movement Studies & Special Education Faculty Publications

This is the third in a series of six articles to discuss the major classes of dietary supplements (vitamins; minerals; amino acids; herbs or botanicals; metabolites, constituents/extracts, or combinations). The major focus is on efficacy of such dietary supplements to enhance exercise or sport performance.

Dietary Supplements And Sports Performance: Minerals, Melvin H. Williams

Human Movement Studies & Special Education Faculty Publications

Minerals are essential for a wide variety of metabolic and physiologic processes in the human body. Some of the physiologic roles of minerals important to athletes are their involvement in: muscle contraction, normal hearth rhythm, nerve impulse conduction, oxygen transport, oxidative phosphorylation, enzyme activation, immune functions, antioxidant activity, bone health, and acid-base balance of the blood. The two major classes of minerals are the macrominerals and the trace elements. The scope of this article will focus on the ergogenic theory and the efficacy of such mineral supplementation. Journal of the International Society of Sports Nutrition. 2( 1): 43-49, 2005.

Improving Clinical Practice Using Clinical Decision Support Systems: A Systematic Review Of Trials To Identify Features Critical To Success, Kensaku Kawamoto, Caitlin A. Houlihan, E. Andrew Balas, David F. Lobach

School of Medical Diagnostics & Translational Sciences Publications

Objective To identify features of clinical decision support systems critical for improving clinical practice. Design Systematic review of randomised controlled trials.
Data sources Literature searches via Medline, CINAHL, and the Cochrane Controlled Trials Register up to 2003; and searches of reference lists of included studies and relevant reviews.
Study selection Studies had to evaluate the ability of decision support systems to improve clinical practice.
Data extraction Studies were assessed for statistically and clinically significant improvement in clinical practice and for the presence of 15 decision support system features whose importance had been repeatedly suggested in the literature.
Results Seventy studies …

Nanosecond Pulsed Electric Fields: A New Stimulus To Activate Intracellular Signaling, Stephen J. Beebe, Karl H. Schoenbach

Bioelectrics Publications

When new technologies are introduced into the scientific community, controversy is expected and both excitement and disappointment enrich the lives of those who initiate the new ideas. It becomes the mission of the “inventors” to embrace the burden of proof to establish their ideas and convince the skeptics and disbelievers who will undoubtedly temper their enthusiasm and test their patience. While open mindedness is generally a scientific motto, those who review patents, manuscripts, and grants do not always readily practice it, even when the evidence is convincingly presented; old ideas and concepts often die hard. So it has been and …

Simulations Of Nanopore Formation And Phosphatidylserine Externalization In Lipid Membranes Subjected To A High-Intensity, Ultrashort Electric Pulse, Q. Hu, R. P. Joshi, K. H. Schoenbach

Bioelectrics Publications

A combined MD simulator and time dependent Laplace solver are used to analyze the electrically driven phosphatidylserine externalization process in cells. Time dependent details of nanopore formation at cell membranes in response to a high-intensity (100kV∕cm), ultrashort (10ns) electric pulse are also probed. Our results show that nanosized pores could typically be formed within about 5ns. These predictions are in very good agreement with recent experimental data. It is also demonstrated that defect formation and PS externalization in membranes should begin on the anode side. Finally, the simulations confirm that PS externalization is a nanopore facilitated event, rather than the …

Review Of Lacan To The Letter: Reading Ecrits Closely, By Bruce Fink, 2004, Hervé Regnauld

Reconstruction: Studies in Contemporary Culture

No abstract provided.

I Connect Therefore I Am: Connectivity And Networking In Bodies, Technologies, Communities, And Selves, Anthony Lambert

Reconstruction: Studies in Contemporary Culture

[First paragraph]

The notion of connection refers to both metaphorical and material practices informing our understandings of the flows of energy and information within human bodies, communities, geographies, and technological networks. Cranny-Francis offers a definition of connection which accounts for the term's significance in the contexts of both Cultural Studies and multimedia literacy:

It refers to the ways in which texts generate meanings through their relationship with other texts, to the development of multimedia technologies that are characterized by their connectivity (the web, the net), and to the ways in which meanings are generated crucially by the connection between texts …

Enhancing The Geriatric Competence Of Urologic Nurses, Karen A. Karlowicz

Ellmer School of Nursing Faculty Publications

Editorial. Provides strategies for enhancing the geriatric competence of urologic nurses. Improvements in nursing practice and in other health care professions; Considerations in caring for older adults; Implications for nursing practice.

A Comparison Of Esomeprazole And Lansoprazole For Control Of Intragastric Ph In Patients With Symptoms Of Gastro-Oesophageal Reflux Disease, D. A. Johnson, T. Stacy, M. Ryan, T. Wootton, J. Willia, K. Hornbuckle, W. Brooks, M. Doviak

Mathematics & Statistics Faculty Publications

Background: Intragastric acid suppression is the most direct measure of the pharmacodynamic efficacy of proton pump inhibitors, which are the most effective drugs for acid-related diseases.

Aim: To compare the effectiveness of once and twice daily dosing of lansoprazole and esomeprazole in controlling intragastric acidity ( target gastric pH > 4.0) over a 24-hour period.

Methods: In an open-label, two-way crossover study, 45 Helicobacter pylori-negative patients with gastro-oesophageal reflux disease were randomized to receive one of two regimens: 30 mg lansoprazole or esomeprazole 40 mg once daily. Intragastric pH was assessed by 24-hour pH monitoring on day 5 of each regimen. …

Symptoms Of Gastro-Oesophageal Reflux Disease And The Severity Of Obstructive Sleep Apnoea Syndrome Are Not Related In Sleep Disorders Center Patients, H.-N. Kim, R. D. Vorona, M. P. Winn, M. Doviak, D. A. Johnson, J. Catesby Ware

Mathematics & Statistics Faculty Publications

Background: Studies suggest obstructive sleep apnea syndrome (OSAS) frequently manifests in patients with gastroesophageal reflux disease (GERD) and that there may be a causal relationship.

Aim: To determine the relationship between OSAS and symptoms of GERD.

Methods: Consecutive patients referred to the Sleep Disorders Center (SDC) 18 years and older with polysomnographically defined OSAS were evaluated prospectively for GERD using a validated symptoms questionnaire. The GERD and OSAS relationship was assessed by 1) determining frequency of GERD in patients with and without OSAS; 2) ascertaining the relationship between OSAS severity categories and presence of GERD; 3) examining GERD score in …

Effects Of Ultrasonic Scaling And Hand-Activated Scaling On Tactile Sensitivity In Dental Hygiene Students, Danielle L. Ryan, Michele Darby, Susan L. Tolle, Deborah Bauman, Dayanand Naik

Dental Hygiene Faculty Publications

Purpose. This study was conducted to determine if tactile sensitivity varies in dental hygiene students who use the ultrasonic scaler, as compared to those who scale with hand-activated instruments.

Methods. A two-group, randomized subjects, pretest-posttest design was carried out mid-semester for five weeks on 40 first-year dental hygiene students who met the inclusion criteria of this study and who agreed to participate. A convenience sample of 40 consenting, first-year dental hygiene students were randomly assigned to one of two groups (experimental or control). After establishing a baseline tactile sensitivity score with the Vibratory Sensory Analyzer (VSA), experimental group subjects used …

Factors That Influence Mammography Use Of Community Health Workers, Cynthia M. Kratzke

Health Services Research Dissertations

Community health worker (CHW) interventions promote early detection of breast cancer and mammography use to help eliminate health disparities for minority and low-income women. Data trends show lower mammography use among this population although CHW interventions have been shown to promote mammography use. However, CHW interventions have not been tested sufficiently to examine the factors that influence mammography use of CHWs.

This cross-sectional study examined the factors that influence mammography use of CHWs and the relationship of self-efficacy, social norms, and mammography use of CHWs. The PRECEDE model served as the framework combining social factors, beliefs, attitudes, behaviors, and accessibility …

Men, Muscles, And Body Image: Comparisons Of Competitive Bodybuilders, Weight Trainers, And Athletically Active Controls, T. C. Pickett, R. J. Lewis, T. F. Cash, H. G. Pope

Psychology Faculty Publications

Objectives: To investigate body image and psychosocial adjustment among competitive bodybuilders, non-competitive weight trainers, and athletically active men.

Methods: Participants were 40 men in each of the three groups who were assessed on body composition and multiple facets of body image evaluation, investment and anxiety, eating attitudes, and social self esteem.

Results: Relative to the other two groups, competitive bodybuilders had greater body mass due to fat-free body mass. Although groups did not differ in their situational body image discomfort, competitive bodybuilders and weight trainers had a more positive global appearance evaluation and were more psychologically invested in their physical …

Application Of Queuing Theory And Procedure Time Estimation In A Local Healthcare System, Galina Tsoy

Engineering Management & Systems Engineering Theses & Dissertations

People in the United States pay more for their basic healthcare needs than do people in any other nation in the world. When we consider that the United States is the wealthiest nation in the world, controlling the majority of the world's resources, it seems only reasonable to ask: Why should it be this way?

In an effort to address this problem, this thesis examines two possible methods of improving health care efficiency in hospitals. The thesis is thus in two parts: the first part examines resource allocation in medical units using Queuing Theory, and the second part examines a …

A Privatization Of Politics: Anthony Elliot's Concepts Of The Self (2001), Paula Murphy

Reconstruction: Studies in Contemporary Culture

[First paragraph]

It would be difficult to find a more appropriate image of selfhood in the modern world than that found in Ezra Pound's poem In a Station of the Metro. It is a selfhood which is at once unique and conglomerative, fleetingly visible then tantalizingly out of focus. It is this slippery, indefinable entity that is the subject of Anthony Elliot's book. The title bears witness to the enormous breadth of its subject matter: Concepts of the Self is an attempt to engage with the various contemporary theoretical frameworks through which selfhood is explicated. Elliot's approach is admirably inter-disciplinary, …

Effects Of Ultrasonic And Hand-Activated Scaling On Tactile Sensitivity In Second Year Dental Hygiene Students In A Clinical Setting, Miranda Beeson

Dental Hygiene Theses & Dissertations

The purpose of this study was to determine if time spent instrumenting class III, IV, and V calculus clients, either hand-activated or with an ultrasonic scaler, decreased the tactile sensitivity of the clinician, and if change occurs in index finger, middle finger, and thumb tactile sensitivity prior to and following 45-minute scaling episodes. This study also afforded an opportunity to determine if tactile sensitivity changed in the same dental hygiene students over a one-year period of time by comparing data with that of a similar study conducted in the fall of 2002. Random assignment and a sample size of 25 …

Schizophrenics, Cyborgs And The Pitfalls Of Posthumanism, Angela Woods

Reconstruction: Studies in Contemporary Culture

[Editors' Introduction]

In Schizophrenics, Cyborgs and the Pitfalls of Posthumanism, Angela Woods invites us to revisit two canonical analyses of the postmodern: Fredric Jameson's Postmodernism, or The Cultural Logic of Late Capitalism and Donna Haraway's A Manifesto for Cyborgs: Science, Technology and Socialist Feminism in the 1980s. Jameson and Haraway introduced to contemporary cultural criticism two posthumanist icons: the schizophrenic, a pathologized victim of postmodernity, and the cyborg, a vision of strategic posthuman subjectivity. In her timely and critical analysis of these articles, Woods challenges the established notion of an oppositional relationship between the schizophrenic and the cyborg. She turns …

The Ultrastructure Of The Olfactory System In Two Species Of Short-Tailed Shrews, Blarina Brevicauda And Blarina Carolinensis, Lisa Johnson Byrum

Theses and Dissertations in Biomedical Sciences

Several studies of the fine structure of the olfactory system of rodents have been conducted, but very little research has been done on members of the Insectivora. The olfactory systems of the northern short-tailed shrew, Blarina brevicauda, and the southern short-tailed shrew, Blarina carolinensis, were examined by light and electron microscopy. These shrews were live trapped in the vicinity of Norfolk, Virginia throughout all months of the year. Olfactory tissues were processed following standard transmission and scanning electron microscopy protocols. The olfactory system structures investigated included the olfactory epitheliumlmucosa (OEM), main olfactory bulb (MOB), accessory olfactory bulb (AOB), …

Kinetic Family Drawings By Filipino Americans, Reihnard Ferrera Flores

EVMS School of Health Professions Theses & Dissertations

Research in the mental health field on Filipino Americans and Filipino- American families is limited. In an attempt to further understand Filipino Americans, this study explores similarities and/or differences between drawings of Filipino Americans and non-Filipino Americans. Subjects consisted of twelve Filipino Americans and sixteen non-Filipino Americans. The Kinetic Family Drawing was utilized to determine graphic differences between drawings of both groups. It was hypothesized that there might be considerable visual differences between drawings by Filipino Americans and by non-Filipino Americans.

The results, however, did not support the hypothesis. When comparing Kinetic Family Drawings of Filipino-American subjects to non-Filipino-American subjects, …

Validation Of The Person Picking An Apple From A Tree Projective Drawing Through Comparative Analysis, Shandra M. Brown

EVMS School of Health Professions Theses & Dissertations

Through imagination, creativity, development, and research, art therapists are attempting to create more reliable and valid assessments in order to help clients most effectively. Although assessment development is a long and difficult process, advancements are being made through research, such as this study, in order for the field of art therapy to respond to past criticisms and continue to grow as a credible and respectable field.

The researchers of this study anticipated that the results would show a correlation between levels of anxiety with formal elements of the Person Picking an Apple from a Tree Projective Drawing (PPAT), as measured …

Exploring Visual Journaling In A Graduate Art Therapy Program, Kathryn E. Dunn

EVMS School of Health Professions Theses & Dissertations

This study explored visual journaling in the Graduate Art Therapy Program at Eastern Virginia Medical School, using a Participatory Action Research model. Eight students, from the art therapy class of 2004, and four faculty members volunteered and participated. Two complete cycles of inquiry were completed and changes were implemented within the program based on researcher collaboration with student and faculty stakeholders. Data consisted of questionnaires, magazine collages, and discussion material. Questionnaire and discussion data were analyzed by the researcher using direct question analysis. Themes of the artwork were pulled from stakeholders’ verbal and written comments. Results from the first cycle …

Visual Predictors Of Relapse In The Artwork Of Adult Substance Abusers, Danica Aimeè Vallery

EVMS School of Health Professions Theses & Dissertations

This study hypothesized that five visual predictors of relapse previously found statistically significant by Dickman, Dunn and Wolf (1996) and Williar (2002), in the artwork of adult substance abusers, would again be found statistically significant predictors of relapse, in the artwork of the group identified as a high risk for relapse in Williar’s study. The body of artwork studied included twenty-two previously acquired, studied, and archived drawings (Williar, 2002), created by 22 chemically dependent adults. All subjects completed the assessment of warning signs for relapse (AWARE)(Harris & Miller, 2000) and were grouped as either high or low risk for relapse …

Knitting In Art Therapy: An Exploratory Study, Mollie Irene Howey Tracy

EVMS School of Health Professions Theses & Dissertations

While knitting has long been considered a functional craft, there is significant evidence to support knitting as an art form. Current research exploring the artistic, meditative, and therapeutic qualities of knitting was reviewed and findings indicated scarce research on knitting in art therapy. In this phenomenological study, six female knitters were interviewed and the author addressed her personal experience as well. Several themes were identified: the freedom felt when knitting, keeping one’s hands busy, reduction of anxiety, sharing the finished piece with others, a connection to self and to others, and knitting as a bridge into more traditional art therapy …