Medicine and Health Sciences Commons^™

An Approach To Identifying The Biomechanical Differences Between Intercostal Cartilage In Subjects With Pectus Excavatum And Normals In Vivo: Reconstruction And Ct Registration, Zhenzhen Yan

Electrical & Computer Engineering Theses & Dissertations

Pectus excavatum (PE) is a congenital chest wall deformity affecting the ribs and sternum and exhibiting a concave appearance in the anterior chest wall. In this thesis, we describe a study to investigate in vivo differences in the pectus excavatum rib cage and outline steps using normals and pectus patients data in developing models and methods to be used in carrying out the study. We propose methods to develop reconstructed models in order to enable proper registration between data collection points (DCPs) on the 3D CT rib cage model and CT skin surface model and registration between CT surrogate models …

In Vitro Comparison Of 360° Unirotational Disposable Prophylaxis Angles Versus 90° Reciprocating Disposable Prophylaxis Angles On Spatter During Rubber Cup Polishing, Kelly Marie Schulz

Dental Hygiene Theses & Dissertations

The purpose of this in vitro study was to compare the traditional 360° unirotational disposable prophylaxis angle (DPA) to a 90° reciprocating DPA in terms of spatter production. The 2x3x3 factorial design involved: 2 types of DP As x 3 types of prophylaxis pastes (fine, medium and coarse) x 3 dental handpiece revolutions per minute (rpm) settings (1500, 2000, and 3000). The eStylus'™ operated the DP As under controlled speeds. Using a mounted dental manikin, 90° reciprocating DP As and 360° unirotational DP As were evaluated for spatter production with the use of prophylaxis pastes of various grits in 270 …

Investigation Of A Validation Technique For The Registration Of 3d Points Directly To Subjects With Pectus Excavatum, Taryn Tacosa Cuper

Computational Modeling & Simulation Engineering Theses & Dissertations

Pectus excavatum (PE) is a congenital deformity that results in a "caved in" appearance of the chest wall. The cause of this condition is unknown, but research suggests that an in vivo investigation of the biomechanical properties of the costal cartilages of subjects with PE may offer insight. Force and deflection measurements are proposed as a way to obtain this data; however, accurate location of cartilage from the skin level would be required for such an effort. Given the multiple potential sources of error with this process, a validation procedure to ensure the appropriateness of the findings must be developed; …

College Students Concern Toward Public Intoxication, Ashley N. Mason

Sociology & Criminal Justice Theses & Dissertations

A survey of college students was administered in order to better understand why students choose to either walk after consuming alcoholic beverages or drive after consuming alcoholic beverages. Students were asked to answer demographic questions along with opinion questions as well. The main variables used in this study were perceived severity of offense, perceived certainty of offense (i.e. level of concern about getting stopped), moral condemnation and punishment avoidance.

Univariate, bivariate and multivariate analyses were examined to see what characteristics have an impact on students behavior regarding public intoxication. Although significant with one or both dependent variables, perceived severity, perceived …

Cannabinoids: A Novel Treatment Strategy For Retinal Neurodegenerative Disorders, Sandeep Samudre

Theses and Dissertations in Biomedical Sciences

Synthetic and naturally occurring cannabinoids are known to decrease intraocular pressure (IOP). Glaucomatous damage to the retina and optic nerve progresses even after therapy to maintain normal intraocular pressure (IOP). Topical application of cannabinoids decreases IOP while not affecting blood pressure or heart rate. Based upon their effects on other tissues, we hypothesize that these analogs reduce IOP and may also confer direct neuroprotective effects on the retina, possibly via CB1 and/or CB2 receptors. The purpose of this study is to determine if the newly synthesized CB agonists, lipid soluble O-1812 (CB 1), and water soluble O-2545 (CB 1

The …

An Assessment Of An Education Intervention On Youth Sports Coaches Knowledge Of Concussions, Heidi Elizabeth Brigham

Human Movement Studies & Special Education Theses & Dissertations

Research has shown that sport related concussions are occurring at high rates across the United States. Research has also shown that there are many misconceptions among youth sports coaches regarding concussions. Therefore the purpose of this study was to determine the effects of an educational intervention on the knowledge of concussion recognition, management and prevention for youth sports coaches. A secondary purpose was to compare various relationships between demographic characteristics and the concussion knowledge assessment scores. A twenty-one question multiple choice assessment and 16 option symptom recognition checklist was utilized to assess concussion knowledge prior to and following an educational …

The Application Of Innovative High-Throughput Techniques To Serum Biomarker Discovery, Izabela Debkiewicz Karbassi

Theses and Dissertations in Biomedical Sciences

Time-of-flight mass spectrometry continues to evolve as a promising technique for serum protein expression profiling and biomarker discovery. As seen in our initial SELDI-TOF MS and MALDI-TOF MS profiling study of serum for the assessment of breast cancer risk, many profiling strategies typically employ single chemical affinity beads or surfaces to decrease sample complexity of dynamic fluids like serum. However, most proteins, captured on a particular surface or bead, are not resolved in the lower mass range where mass spectrometers are most effective. To this end we have designed an expression profiling workflow that utilizes immobilized trypsin paramagnetic beads in …

Real-Time Ultrasound Simulation For Medical Training And Standardized Patient Assessment, Bo Sun

Computational Modeling & Simulation Engineering Theses & Dissertations

With the increasing role played by ultrasound in clinical diagnostics, ultrasound training in medical education has become more and more important. The clinical routine for ultrasound training is on real patients; therefore monitored and guided examinations involving medical students are quite time-constrained. Furthermore, standardized patients (SPs), who are increasingly used in medical school for teaching and assessing medical students, need to be augmented. These SPs are typically healthy individuals who can not accurately portray the variety of abnormalities that are needed for training especially when medical examinations involve instrument interactions. To augment SPs in a realistically effective way and also …

Do Hospitalists Or Physicians With Greater Inpatient Hiv Experience Improve Hiv Care In The Era Of Highly Active Antiretroviral Therapy? Results From A Multicenter Trial Of Academic Hospitalists, John A. Schneider, Qi Zhang, Andrew Auerbach, David Gonzales, Peter Kaboli, Jeffrey Schnipper, Tosha B. Wetterneck, David L. Pitrak, David O. Meltzer

Community & Environmental Health Faculty Publications

Background. Little is known about the effect of provider type and experience on outcomes, resource use, and processes of care of hospitalized patients with human immunodeficiency virus (HIV) infection. Hospitalists are caring for this population with increasing frequency.

Methods. Data from a natural experiment in which patients were assigned to physicians on the basis of call cycle was used to study the effects of provider type—that is, hospitalist versus non hospitalist—and HIV-specific inpatient experience on resource use, outcomes, and selected measures of processes of care at 6 academic institutions. Administrative data, inpatient interviews, 30-day follow-up interviews, and the National Death …

Childhood Obesity In Minority Populations In The United States, Qi Zhang, Youfa Wang

Community & Environmental Health Faculty Publications

Obesity became a public health crisis in the United States, which affects both adults and children.^1,2,24,25 Approximately 31% of U.S. children and adolescents aged 2-19 years were overweight or obese, and almost 17% were obese in 1999-2004.^3-5,24 Studies suggest that increased consumption of more energy-dense, nutrient-poor foods with high levels of sugar and saturated fats, combined with reduced physical activity, have contributed to the rising obesity epidemic among children.^6,21,28 Childhood obesity increased the risk of many diet-related chronic diseases, including type 2 diabetes, cardiovascular disease, hypertension, stroke, and certain forms of cancers.⁷ It is important to …

A Comparison Of Different Methods For Predicting Cancer Mortality Counts At The State Level, Corinne Wilson

Virginia Journal of Science

Cancer is a major health issue in the United States. Reliable estimates of yearly cancer mortality counts are essential for resourcing and planning. The American Cancer Society has used several methods of forecasting to estimate the future cancer burden and researchers are continually working to develop new methods with improved performance. There have been studies comparing different models for predicting the US cancer mortality counts. This study explores and compares several different models for cancer mortality count predictions at the state level, principally for the state of Virginia. Results of the comparisons appear to show the final improved model to …

Challenge Course Effectiveness: The Impact On Leadership Efficacy And Work Efficacy Among College Students, Theresa Odello, Eddie Hill, Edwin Gomez

Human Movement Studies & Special Education Faculty Publications

Challenge courses have become increasingly popular in recent years. Many groups are turning to half-day challenge courses due to time and financial constraints. Yet, few studies have quantified the benefits of a half-day course. The purpose of this study was to examine the effects of participation in a four-hour challenge course on leadership efficacy and work efficacy of college students. Pretest, posttest, and follow-up questionnaires were utilized. T-test analyses found that participating in a challenge course has a significant positive effect on increasing one’s leadership and work efficacy from pretest to posttest, after participation in a four-hour challenge course. This …

The Increasing Number Of Clinical Items Addressed During The Time Of Adult Primary Care Visits, Elmer D. Abbo, Qi Zhang, Martin Zelder, Elbert S. Huang

Community & Environmental Health Faculty Publications

BACKGROUND: Primary care physicians report that there is insufficient time to meet patients' needs during clinical visits, but visit time has increased over the past decade.

OBJECTIVE: To determine whether the number of clinical items addressed during the primary care visit has increased, and if so, whether this has been associated with changes in visit length and the pace of clinical work.

DESIGN: Analysis of non-hospital-based adult primary care visits from 1997 to 2005, as reported in the National Ambulatory Medical Care Survey.

PARTICIPANTS: A total of 46,431 adult primary care visits.

MEASUREMENTS: We assessed changes over time for …

Modeling Physical Activity In Working Adults: How Suitable Is The Expanded Parallel Process Model?, Adwoa B-H-Sam

Health Services Research Dissertations

This study is an assessment of the usefulness of the Expanded Parallel Process Model in predicting health enhancing physical activity as an outcome variable. The theory is tested in the context of risk for coronary heart disease and involves secondary analyses of a dataset from a group of working adults. These individuals had elected first to participate in a health plan ‘Quality Improvement Study’ and were then randomly selected to receive an intervention program designed to get people to be more active.

Data on self-reported demographics, physical activity levels, health status characteristics and perceptions measured on a Likert-type scale known …

Longitudinal Association Of Sleep-Disordered Breathing And Nondipping Of Nocturnal Blood Pressure In The Wisconsin Sleep Cohort Study, Khin Mae Hla, Terry Young, Laurel Finn, Paul E. Peppard, Mariana Szklo-Coxe, Maryan Stubbs

Community & Environmental Health Faculty Publications

Study objectives: The association of sleep-disordered breathing (SDB) and blunting of normal nocturnal lowering of blood pressure (BP) (nondipping) has only been examined cross-sectionally. The purpose of this study is to investigate whether SDB is prospectively associated with nondipping.

Methods: The longitudinal association between SDB and incident nondipping was examined in a subsample of 328 adults enrolled in the Wisconsin Sleep Cohort Study who completed 2 or more 24-hour ambulatory BP studies over an average of 7.2 years of follow-up. SDB identified by baseline in-laboratory polysomnography was defined by apnea-hypopnea index (AHI) categories. Systolic and diastolic nondipping was defined by …

Continence Care: The Need For Creativity And Innovation, Karen A. Karlowicz

Ellmer School of Nursing Faculty Publications

(First paragraph) In April 2007, I attended a conference quite different from anything I had previously experienced. The conference, Innovating for Continence: The Engineering Challenge, was hosted by the Simon Foundation for Continence. As the title implies, this was not your usual conference about the diagnosis, treatment, and management of urinary incontinence. Rather, it was a conference dedicated to exploring technological advances in continence care. The central question throughout this two-and-a-half day event was, "What can be done to simulate continence technology to ensure the most effective management for persons who suffer with this problem?"

New Words To Promote Communication And Collaboration Among The Oral Health Care Team, Trisha Nunn, Michele L. Darby, Susan H. Kass, Connie L. Kracher, Linda S. Stewart, Don R. Symington, Cheryl Westphal

Dental Hygiene Faculty Publications

No abstract provided.

Advancing Epidemiological Science Through Computational Modeling: A Review With Novel Examples, Scott M. Duke-Sylvester, Eli N. Perencevich, Jon P. Furuno, Leslie A. Real, Holly Gaff

Biological Sciences Faculty Publications

Computational models have been successfully applied to a wide variety of research areas including infectious disease epidemiology. Especially for questions that are difficult to examine in other ways, computational models have been used to extend the range of epidemiological issues that can be addressed, advance theoretical understanding of disease processes and help identify specific intervention strategies. We explore each of these contributions to epidemiology research through discussion and examples. We also describe in detail models for raccoon rabies and methicillin-resis-tant Staphylococcus aureus, drawn from our own research, to further illustrate the role of computation in epidemiological modeling.

Application Of The Interactional Model Of Cultural Diversity To Identify Diversity Climate Factors Associated With Organizational Effectiveness In Accredited U.S. Physical Therapist Education Programs, Elizabeth Francis Giles

Health Services Research Dissertations

Accredited U.S. physical therapist education programs are responsible for the preparation of its graduates to provide culturally sensitive care to meet the physical therapy needs of an increasingly diverse population. While the importance of workforce diversity has been articulated, the effect of diversity climate on organizational effectiveness within accredited U.S. physical therapist education programs has not been described. The purpose of this study was to evaluate the effectiveness of the Interactional Model of Cultural Diversity (IMCD, Cox, 1993) as a theoretical framework to identify diversity climate factors associated with organizational effectiveness in accredited U.S. physical therapist education programs. A descriptive, …

Spatio-Temporal Analysis Of The Relationship Between Wnv Dissemination And Environmental Variables In Indianapolis, Usa., Hua Liu, Qihao Weng, David Gaines

Political Science & Geography Faculty Publications

Background: This study developed a multi-temporal analysis on the relationship between West Nile Virus (WNV) dissemination and environmental variables by using an integrated approach of remote sensing, GIS, and statistical techniques. WNV mosquito cases in seven months (April-October) of the six years (2002–2007) were collected in Indianapolis, USA. Epidemic curves were plotted to identify the temporal outbreaks of WNV. Spatial-temporal analysis and k-mean cluster analysis were further applied to determine the high-risk areas. Finally, the relationship between environmental variables and WNV outbreaks were examined by using Discriminant Analysis.

Results: The results show that the WNV epidemic curve reached its peak …

A Study Of The Distribution And Abundance Of The Adult Malaria Vector In Western Kenya Highlands, Li Li, Ling Bian, Guiyun Yan

Political Science & Geography Faculty Publications

Background: A sharp rise in the malaria mortality rate has been observed recently in western Kenya. Malaria is transmitted by mosquito vectors. Malaria control strategies can be more successful if the distribution and abundance of mosquito vectors is predicted. However, how mosquito vectors are distributed in space remain poor understood, and this question is rarely studied using spatial methods. This study aims to provide a better understanding of the distribution and abundance of mosquito vectors. To achieve this objective, spatial and non-spatial methods were employed. The data on the distribution of adult mosquitoes, and mosquito breeding habitats in a study …

Energy Balance During Backpacking, L. C. Hill, D. P. Swain, E. L. Hill

Rehabilitation Sciences Faculty Publications

Energy expenditure and energy intake were determined in three Subjects during a 160-kilometer backpacking trip. Prior to the trip, heart rate and oxygen consumption during treadmill walking while carrying a backpack were measured. Subjects recorded heart rate during hiking. Heart rate Was used to estimate energy expenditure based on the heart rate: oxygen consumption relationship (Heart Rate Method). Expenditure was also estimated from distance walked and elevation gained (Terrain Method). Subjects recorded food consumption, and were weighed upon finishing the hike. Mean heart rate during biking was 105 +/- 12 beats per Minute. According to the Heart Rate Method, net …

An Efficient Algorithm For Biomarker Identification, Jiang Li, Rick Mckenzie, Lisa Cazares, Richard Drake, John Semmens

Electrical & Computer Engineering Faculty Publications

No abstract provided.

Enhancing Research In A Family Medicine Program: One Institution's Story, Fred Tudiver, Kaethe P. Ferguson, Jim L. Wilson, Gary Kukulka

Biological Sciences Faculty Publications

Background and Objectives: To enhance research productivity among East Tennessee State University's faculty, the Department of Family Medicine developed and implemented a multi-component initiative to expand multidisciplinary primary care research.

Methods: The research support infrastructure expanded to include a family physician research director, three PhD faculty researchers, two research assistants, a statistician, and a grant/science writer. A monthly seminar series, quarterly workshops, and a formal mentoring program paired more-experienced with less-experienced faculty researchers. Through a competitive mechanism in which junior faculty submitted proposals, a multidisciplinary committee selected two family physician researchers to receive protected time to develop their research.

Results: …

Dependence In Prestroke Mobility Predicts Adverse Outcomes Among Patients With Acute Ischemic Stroke, Mary I. Dallas, Shari Rone-Adams, John L. Echternach, Lawrence M. Bass, Dawn M. Bravata

Rehabilitation Sciences Faculty Publications

Background and Purpose - Stroke survivors are commonly dependent in activities of daily living; however, the relation between prestroke mobility impairment and poststroke outcomes is poorly understood. The primary objective of this study was to evaluate the association between prestroke mobility impairment and 4 poststroke outcomes. The secondary objective was to evaluate the association between prestroke mobility impairment and a plan for physical therapy.

Methods - This was a secondary analysis of the National Stroke Project data, a retrospective cohort of Medicare beneficiaries who were hospitalized with an acute ischemic stroke (1998 to 2001). Logistic-regression modeling was used to examine …

Maldi Mass Spectrometry Imaging For The Discovery Of Prostate Carcinoma Biomarkers, Lisa Harris Cazares

Theses and Dissertations in Biomedical Sciences

The elucidation of new biological markers of prostate cancer (PCa) should aid in the detection, and prognosis of this disease. Diagnostic decision making by pathologists in prostate cancer is highly dependent on tissue morphology. The ability to localize disease-specific molecular changes in tissue would help improve this critical pathology decision making process. Direct profiling of proteins in tissue sections using MALDI imaging mass spectrometry (MALDI-IMS) has the power to link molecular detail to morphological and pathological changes, enhancing the ability to identify candidates for new specific biomarkers. However, critical questions remain regarding the integration of this technique with clinical decision …

Gene Therapy Using Tet-Repressor System To Modulate Prostate Tumor Microenvironment, Nazita Yousefieh

Theses and Dissertations in Biomedical Sciences

Prostate cancer is the most commonly diagnosed malignancy in men in the United States and is projected to be the third most frequent cause of male cancer-related deaths in 2007 after lung and skin cancers. The initial treatment for prostate cancer at early stages is prostatectomy or radiation, which usually is curative. However, approximately 20% of patients are not cured by such treatments and their cancer recurs, sometimes with long latencies. In other patients prostate cancer is diagnosed only after the cancer has metastasized and there are no effective therapies at this stage. Therefore immunotherapy seems to be a promising …

Reference Group Data For The Functional Gait Assessment, Martha L. Walker, Alvis G. Austin, Gina M. Banke, Suzanne R. Foxx, Lynn Gaetano, Laurie A. Gardner, Jill Mcelhiney, Kisiah Morris, Liz Penn

Rehabilitation Sciences Faculty Publications

Background and Purpose: The Functional Gait Assessment (FGA) is a clinical tool for evaluating performance in walking. The purpose of this study was to determine age-referenced norms for performance on the FGA in community-living older adults.

Subjects: Subjects were 200 adults, ages 40 to 89 years, living independently.

Methods: Each subject completed the FGA one time and was scored simultaneously by 2 testers.

Results: The intraclass correlation coefficient for interrater reliability was .93. Mean scores for the FGA ranged from 29/30 for adults in their 40s to 21/30 for adults in their 80s.

Discussion and Conclusion: Patient performance on the …

Microfabrication Of An Optical Chamber For Exposing Living Cells To Pulsed Electric Fields, Saleh Sheikh

Electrical & Computer Engineering Theses & Dissertations

I have fabricated a chamber which enables the application of Nanosecond Pulsed Electric Fields (nsPEFs) to living cells while monitoring their real time fluorescence with an inverted microscope. The No. I thickness (150µm nominal) coverslip glass substrate used for fabrication allows the use of high numerical aperture oil immersion objectives for imaging intracellular organelles. Electrodes are fabricated by first evaporating a chromium adhesion layer, followed by a nickel seed layer. Subsequently, an ultra-thick positive photoresist is applied and patterned to create a 30µm thick electroplating mold. The electrodes are then electrodeposited into the mold from a nickel sulfamate plating bath. …

Debate: A Teaching-Learning Strategy For Developing Competence In Communication And Critical Thinking, Michele Darby

Dental Hygiene Faculty Publications

The article highlights key benefits from debate as a teaching-learning strategy for developing critical thinking and analytical skills while fostering teamwork and communication. According to the author, it is an effective pedagogical strategy because of the level of responsibility for learning and active involvement required by all student debaters. She also notes that the debate strategy can be used as a method to achieve competencies in baccalaureate and graduate dental hygiene programs.