Medicine and Health Sciences Commons^™

Somatosensory Deficits In Post-Acl Reconstruction Patients: A Case-Control Study, Johanna M. Hoch, William O. Perkins, Jonathan R. Hartman, Matthew C. Hoch

Rehabilitation Sciences Faculty Publications

Introduction: Diminished cutaneous detection thresholds have been identified in patients with multiple orthopedic conditions, and these phenomena may occur in postanterior cruciate ligament reconstructed (ACLR) patients. The purpose of this study was to determine if differences in lower extremity cutaneous detection thresholds exist in post-ACLR patients when compared with healthy controls. Methods: Fifteen individuals who were post-ACLR and 15 individuals who had no history of knee injury participated. Light touch cutaneous detection thresholds were assessed at 4 locations on the foot and ankle (first metatarsal, fifth metatarsal, medial malleolus, and lateral malleolus). Nonparametric statistics examined group differences between the …

Impact Of A Localized Lean Six Sigma Implementation On Overall Patient Safety And Process Efficiency, Luvianca Gil, Pilar Pazos, Mamadou Seck, Rolando Delaguila

Engineering Management & Systems Engineering Faculty Publications

Continuous quality improvement tools have caught the attention of the Health Care Industry as a solution to process efficiency, patient safety and cost reduction. This research explores the impact of a Lean Six Sigma (LSS) process improvement initiative in overall process efficiency and patient safety in two Labor and Delivery (L+D) units of two large hospital providers. This study focuses on the application of modeling and simulation methodology to investigate the influence of a localized process improvement intervention on the overall L+D unit output, by considering patient flow, system capacity and unit performance. The simulation models capacity profiles and patient …

Efficacy Of Elder Support And Education On Measles Vaccination Rates In Amish Communities, Amber Porter, Alfaro Mariateresa, Lan Marietta, Kristen Schriver, Michelle Douglas, Bonnie Lozy, Emily Burgos

OUR Journal: ODU Undergraduate Research Journal

Background: Proposed study within Amish community to increase measles vaccinations and education about measles: etiology and transmission, aseptic techniques, and quarantine/isolation.

Significance: The majority of Amish people are unvaccinated. Massive outbreaks of measles (363 cases in Ohio) within Amish communities.

Method: Non-random, convenience sampling of participants in two Amish communities: Indiana and Illinois.

Analysis: Closed-ended questions with nominal data. Biological measurements with integral data. Qualitative analysis, chi square and statistical analysis used to determine outcome and results.

Drug Court Versus Incarceration: Which Is More Effective?, Erin Alexander, Kathryn Apperson, Megan Flannigan, Sarah Jean, Lintag Rosalina, Jennifer Lynch, Ethan Schwartz

OUR Journal: ODU Undergraduate Research Journal

Aim: This study explores the affect drug court treatment programs have on the sobriety and employment status of the participants.

Background: Drug addiction has been an ongoing issue nationwide, and with addiction comes drug related crimes. Currently the preferred solution to this epidemic is to impose longer and longer lengths of incarceration for every incurred infraction. Methods: A descriptive correlational design will be used for this research study to evaluate the effectiveness of drug court compared to incarceration. The participants will be chosen by a random sampling of 100 residents of the Hampton Roads area of Virginia--50 …

Effects Of Peer Support Group On Rates Of Suicide Attempts, Suicidal Thoughts, And Incidences Of Self-Harm For Sexual-Minority High School Students, Samantha Fleming, Rebecca O'Neill, Allyson Jett, Haley Mann, Ashlee Peters, Deja Dixon

OUR Journal: ODU Undergraduate Research Journal

The torment sexual minority youth experience can take a psychological toll without access to a support system. The purpose of this proposal is to determine whether an after-school peer support group for sexual minority youth could decrease incidences of suicidal thoughts, attempts, and/or self-inflicted injuries.

The Effect Of An Interprofessional Registered Nurse-Physical Therapist Team On Reducing Prescribed Opioid Dependence In Patients With Chronic Lower Back Pain, Amber Chesney, Stephanie Jan, Amanda Pedrazoli, Brandon Simmons, Kaylene Woods, Nicole Yeats

OUR Journal: ODU Undergraduate Research Journal

Long-term prescribed opioid use for chronic pain is shown to reduce recovery potential and increase risk for dependence, which is contributing to the nationwide opioid crisis. There is a need for an innovative, multidisciplinary approach to address prescription opioid dependence. We propose implementation of a community-based interprofessional registered nurse-physical therapist team (IRNPTT) focused on reduction of opioid dependence in adult patients with chronic lower back pain.

Effects Of Instrument Handle Design On Dental Hygienists' Forearm Muscle Activity During Scaling, Jessica R. Suedbeck, Susan L. Tolle, Gayle Mccombs, Martha L. Walker, Daniel M. Russell

Dental Hygiene Faculty Publications

Purpose: The purpose of this study was to determine the effects of 4 different commercially available instrument handle designs (A. 16 grams and 12.7 mm diameter, B. 23 grams and 11.1 mm diameter, C. 21 grams and 7.9 mm diameter and D. 18 grams and 6.35 mm diameter) on the muscle activity of four forearm muscles during a simulated scaling experience.

Methods: A convenience sample of 27 (n=27) dental hygienists used a Columbia 13/14 curet with four different instrument handles to scale artificial calculus from typodont teeth. Each participant's muscle activity was measured using surface electromyography (sEMG).

Results: Similar muscle …

Gopher Fitstep Pro Accuracy When Measuring Steps And Moderate-To-Vigorous Physical Activity, Ali Brian, Justin A. Haegele

Human Movement Studies & Special Education Faculty Publications

Background: The Gopher FITStep Pro (GFSP) is a commercially available objective physical activity monitor that records steps taken and moderate-to-vigorous physical activity (MVPA).

Objective: The purpose of this study was to evaluate the accuracy of the GFSP for measuring steps taken in a guided walking condition and MVPA during planned fitness activities.

Method: University-aged participants (N = 35, M_age = 20) wore two GFSP (right and left side) pedometers and one ActiGraph GT3X+ accelerometer during both conditions.

Results: Paired samples t-tests determined that self-step counts in the guided walking condition were not significantly different …

Physical Activity And Sedentary Behaviors In Urban Chinese Children: Grade Level Prevalence And Academic Burden Associations, Xihe Zhu, Justin A. Haegele, Yan Tang, Xueping Wu

Human Movement Studies & Special Education Faculty Publications

The objectives of this study were (a) to report grade level prevalence in physical activity and sedentary behaviors and (b) to examine academic burden associations with these behaviors. School-aged children (n = 48,118) reported their physical activity, perception of physical activity sufficiency, factors for activity insufficiency, homework hours, and screen time in a typical week. Data were analyzed using general linear models and logistic regression models of Complex Samples. Prevalence results showed that children had lower physical activity and lower screen viewing time, but higher homework time during transition grades (6th, 9th, and 12th) and high school years. Academic burden …

The Impact Of Rivalry Antecedents On Mediated Demand For An Individual Sport, Lamar Reams, Terry Eddy

Human Movement Studies & Special Education Faculty Publications

In contrast to research examining the social-psychological aspects of how sport fans perceive rivalry games in team sports, far less is known regarding the impact rivalries have on mediated consumer demand, a marketing outcome of interest to sport researchers and practitioners. Guided by economic demand theory, the current study developed a model to empirically examine the impact of Tyler and Cobbs' (2015) rivalry antecedents (conflict, peer, bias) on fan interest for an individual sport. The three-dimensional framework provided the foundation for the selection of thirteen rivalry-related variables, in addition to control determinants established from prior literature. Results from the estimation …

Preferential Lineage-Specific Differentiation Of Osteoblast-Derived Induced Pluripotent Stem Cells Into Osteoprogenitors, Casey L. Roberts, Silvia S. Chen, Angela C. Murchison, Rebecca A. Ogle, Michael P. Francis, Roy C. Ogle, Patrick C. Sachs

School of Medical Diagnostics & Translational Sciences Publications

While induced pluripotent stem cells (iPSCs) hold great clinical promise, one hurdle that remains is the existence of a parental germ-layer memory in reprogrammed cells leading to preferential differentiation fates. While it is problematic for generating cells vastly different from the reprogrammed cells' origins, it could be advantageous for the reliable generation of germ-layer specific cell types for future therapeutic use. Here we use human osteoblast-derived iPSCs (hOB-iPSCs) to generate induced osteoprogenitors (iOPs). Osteoblasts were successfully reprogrammed and demonstrated by endogenous upregulation of Oct4, Sox2, Nanog, TRA-1-81, TRA-16-1, SSEA3, and confirmatory hPSC Scorecard Algorithmic Assessment. The hOB-iPSCs formed embryoid bodies …

A Neighborhood-Wide Association Study (Nwas): Example Of Prostate Cancer Aggressiveness, Shannon M. Lynch, Nandita Mitra, Michelle Ross, Craig Newcomb, Karl Dailey, Tara Jackson, Charnita M. Zeigler-Johnson, Harold Riethman

School of Medical Diagnostics & Translational Sciences Publications

Purpose

Cancer results from complex interactions of multiple variables at the biologic, individual, and social levels. Compared to other levels, social effects that occur geospatially in neighborhoods are not as well-studied, and empiric methods to assess these effects are limited. We propose a novel Neighborhood-Wide Association Study(NWAS), analogous to genome-wide association studies(GWAS), that utilizes high-dimensional computing approaches from biology to comprehensively and empirically identify neighborhood factors associated with disease.

Methods

Pennsylvania Cancer Registry data were linked to U.S. Census data. In a successively more stringent multiphase approach, we evaluated the association between neighborhood (n = 14,663 census variables) and prostate …

Neonatal Hypoglycemia In Diabetic Mothers: A Systematic Review, Brook T. Alemu, Olaniyi Olayinka, Hind A. Baydoun, Matthew Hoch, Muge Akpinar-Elci

Community & Environmental Health Faculty Publications

Hypoglycemia occurs in approximately 8-30% of neonates born to mothers with diabetes. The full extent of the individual and contextual risk factors of hypoglycemia remains unclear and no systematic review of the available studies exists to date. We identified published studies using PubMed and EBSCO host search engines. A modified STROBE statement was used to assess studies' strengths, weaknesses, and generalizability. A total of 16 articles were eligible for full text review. The clinical risk factors in these studies were broadly classified into two: infant-related and mother-related risk factors. The identified infant-related risk factors were SGA, macrosomia, prematurity, lower cord …

Workplace Violence And Hospital Security Programs: Regulatory Compliance, Program Benchmarks, Innovative Strategies, James D. Blando, Maryalice Nocera, Marilyn L. Ridenour, Daniel Hartley

Community & Environmental Health Faculty Publications

The authors describe the issue of workplace violence in hospitals, a New Jersey state law and regulations regarding workplace violence in healthcare, and some innovative strategies that are being utilized to help reduce the occurrence and risk of violence. The authors also discuss compliance with the New Jersey regulations.

Electrosensitization Increases Antitumor Effectiveness Of Nanosecond Pulsed Electric Fields In Vivo, Claudia Muratori, Andrei G. Pakhomov, Loree Heller, Maura Casciola, Elena Gianulis, Sergey Grigoryev, Shu Xiao, Olga N. Pakhomova

Bioelectrics Publications

Nanosecond pulsed electric fields are emerging as a new modality for tissue and tumor ablation. We previously reported that cells exposed to pulsed electric fields develop hypersensitivity to subsequent pulsed electric field applications. This phenomenon, named electrosensitization, is evoked by splitting the pulsed electric field treatment in fractions (split-dose treatments) and causes in vitro a 2- to 3-fold increase in cytotoxicity. The aim of this study was to show the benefit of split-dose treatments for in vivo tumor ablation by nanosecond pulsed electric field. KLN 205 squamous carcinoma cells were embedded in an agarose gel or grown subcutaneously as tumors …

The Effects Of Low-Intensity Therapeutic Ultrasound On Measurable Outcomes: A Critically Appraised Topic, Sarah Daniels, Gabriela Santiago, Jennifer Cuchna, Bonnie Van Lunen

Ellmer School of Nursing Faculty Publications

Therapeutic ultrasound (US) is a popular modality among health care professionals and is used to treat a variety of musculoskeletal conditions. A new technology has been established to allow for the miniaturization of the US unit. Patients receive treatment with the device secured to them, eliminating the portability constraint of traditional US units. Early studies suggest that this portable unit can deliver low-intensity acoustic energy achieving the same temperature increase and pain relief that come from traditional US units, in a more versatile and patient-friendly manner. Clinical Question: What effects does low-intensity therapeutic ultrasound (LITUS) have on measurable outcomes? Summary …

A Comparison Of Screening Tools For The Early Detection Of Peripheral Neuropathy In Adults With And Without Type 2 Diabetes, Jennifer J. Brown, Shana Pribesh, Kimberly G. Baskette, Aaron I. Vinik, Sheri R. Colberg

Educational Leadership & Workforce Development Faculty Publications

Objective. Examine the effectiveness of the 128 Hz tuning fork, two monofilaments, and Norfolk Quality of Life Diabetic Neuropathy (QOL-DN) questionnaire as tools for the early detection of diabetic peripheral neuropathy (DPN) in overweight, obese, and inactive (OOI) adults or those who have prediabetes (PD) or type 2 diabetes (T2D). Research Design and Methods. Thirty-four adults (mean age 58.4 years +/- 12.1) were divided by glycemia (10 OOI normoglycemic, 13 PD, and 11 T2D). Sural nerves were tested bilaterally with the NC-stat DPNCheck to determine sural nerve amplitude potential (SNAP) and sural nerve conduction velocity (SNCV). All other testing …

Key Points From The Updated Guidelines On Exercise And Diabetes, Sheri R. Colberg

Human Movement Studies & Special Education Faculty Publications

From the Introduction:

No doubt remains that the adoption and maintenance of physical activity is important for overall health and blood glucose management in individuals with diabetes and prediabetes. Recently, the American Diabetes Association (ADA) published updated recommendations and precautions about physical activity and exercise in people with type 1 diabetes, type 2 diabetes, and gestational diabetes (1). Given the importance of these topics, it is worth discussing the key changes and updates included in this ADA position statement (PS).

Effects Of Gait Speed Of Femoroacetabular Joint Forces, Joshua T. Weinhandl, Bobbie S. Irmisher, Zachary A. Sievert

Human Movement Studies & Special Education Faculty Publications

Alterations in hip joint loading have been associated with diseases such as arthritis and osteoporosis. Understanding the relationship between gait speed and hip joint loading in healthy hips may illuminate changes in gait mechanics as walking speed deviates from preferred. The purpose of this study was to quantify hip joint loading during the gait cycle and identify differences with varying speed using musculo skeletal modeling. Ten, healthy, physically active individuals performed walking trials at their preferred speed, 10% faster, and 10% slower. Kinematic, kinetic, and electromyographic data were collected and used to estimate hip joint force via a musculoskeletal model. …

Overweight, Obesity, And Screen-Time Viewing Among Chinese School-Aged Children: National Prevalence Estimates From The 2016 Physical Activity And Fitness In China—The Youth Study, Yujun Cai, Xihe Zhu, Xueping Wu

Human Movement Studies & Special Education Faculty Publications

Purpose: This study presents the most recent estimates of prevalence of overweight, obesity, and screen-time viewing among Chinese school-aged children. Demographic differences in these estimates between sexes and resident locales were also examined.

Methods: Cross-sectional analyses of 116,615 Chinese school children 9 to 17 years of age who participated in the 2016 Physical Activity and Fitness in China—the Youth Study project. Outcomes were the prevalence of children's overweight (body mass index [BMI] ≥ 85th - < 95th percentile) and obesity (BMI ≥95th percentile) (defined by the Working Group on Obesity in China) and not meeting screen-time viewing recommendations (“not meeting” was defined as more than 2 h per day of viewing activities after school). Analyses were conducted on the whole sample and by school grade cohorts (primary, junior middle, junior high schools), sex, and residence locales (urban, rural).

Results: Overall, 14.4% (95% confidence interval (CI): 13.8%-15.0%) of children and adolescents were overweight, 11.9% (95% CI: 11.0%-13.0%) were obese, and 36.8% (95% …

Frequency Of Chronic Gastrointestinal Distress In Runners: Validity And Reliability Of A Retrospective Questionnaire, Patrick B. Wilson

Human Movement Studies & Special Education Faculty Publications

Gastrointestinal (GI) symptoms may affect up to 90% of competitors during endurance races. Studies have typically assessed GI symptoms retrospectively or only over an acute timeframe, and information on the validity and reliability of the questionnaires employed is lacking. This investigation aimed to estimate the frequency of GI distress experienced by runners over 30 days and to establish the validity and reliability of a retrospective GI symptom questionnaire. Runners (70 men, 75 women) recorded GI symptoms with a prospective journal for 30 days. Retrospective GI symptom data were then collected after the 30-day period on two occasions within one week. …

From Froot Loops To Fitness: My Journey As An Educator And Person With Diabetes, Sheri R. Colberg

Human Movement Studies & Special Education Faculty Publications

This article is adapted from the address of Dr. Colberg delivered as the recipient of the American Diabetes Association's Outstanding Educator in Diabetes Award for 2016. She delivered the address in June 2016 at the association's 76th Annual Meeting and Scientific Sessions in New Orleans, LA.

Self-Reported Pain In Male And Female Iraq/Afghanistan-Era Veterans: Associations With Psychiatric Symptoms And Functioning, Jennifer C. Naylor, H. Ryan Wagner, Mira Brancu, Megan Shepherd-Banigan, Eric Elbogen, Michelle Kelley, Teresa Fecteau, Karen Goldstein, Nathan A. Kimbrel, Christine E. Marx

Psychology Faculty Publications

Objective. To examine pain symptoms and co-occurring psychiatric and functional indices in male and female Iraq/Afghanistan-era veterans.

Design. Self-reported data collection and interviews of Iraq/Afghanistan-era veterans who participated in a multisite study of postdeployment mental health.

Setting. Veterans were enrolled at one of four participating VA sites.

Subjects. Two thousand five hundred eighty-seven male and 662 female Iraq/Afghanistan-era veterans.

Methods. Nonparametric Wilcoxon rank tests examined differences in pain scores between male and female veterans. Chi-square tests assessed differences between male and female veterans in the proportion of respondents endorsing moderate to high levels of pain vs no pain. Multilevel …

Exosomes Serve As Novel Modes Of Tick-Borne Flavivirus Transmission From Arthropod To Human Cells And Facilitates Dissemination Of Viral Rna And Proteins To The Vertebrate Neuronal Cells, Wenshuo Zhou, Michael Woodson, Biswas Neupane, Fengwei Bai, Michael B. Sherman, Kyung H. Choi, Girish Neelakanta, Hameeda Sultana

Biological Sciences Faculty Publications

Molecular determinants and mechanisms of arthropod-borne flavivirus transmission to the vertebrate host are poorly understood. In this study, we show for the first time that a cell line from medically important arthropods, such as ticks, secretes extracellular vesicles (EVs) including exosomes that mediate transmission of flavivirus RNA and proteins to the human cells. Our study shows that tick-borne Langat virus (LGTV), a model pathogen closely related to tick-borne encephalitis virus (TBEV), profusely uses arthropod exosomes for transmission of viral RNA and proteins to the human- skin keratinocytes and blood endothelial cells. Cryo-electron microscopy showed the presence of purified arthropod/neuronal exosomes …

Anti-Proliferative Role Of Recombinant Lethal Toxin Of Bacillus Anthracis On Primary Mammary Ductal Carcinoma Cells Revealing Its Therapeutic Potential, Rekha Khandia, Bramhadev Pattnaik, Katherikamem Rajukumar, Atul Pateriya, Sandeep Bhatia, Harshad Murugkar, Anil Prakash, Hare Krishna Pradhan, Kildeep Dhama, Ashol Munjal, Sunil K. Joshi

Bioelectrics Publications

Bacillus anthracis secretes three secretary proteins; lethal factor (LF), protective antigen (PA) and edema factor (EF). The LF has ability to check proliferation of mammary tumors, chiefly depending on mitogen activated protein kinase (MAPK) signaling pathway. Evaluation of therapeutic potential of recombinant LF (rLF), recombinant PA (rPA) and lethal toxin (rLF + rPA = LeTx) on the primary mammary ductal carcinoma cells revealed significant (p < 0.01) reduction in proliferation of tumor cells with mean inhibition indices of 28.0 ±1.37% and 19.6 ± 1.47% respectively. However, treatment with rPA alone had no significant anti-proliferative effect as evident by low mean inhibition index of 3.4 ± 3.87%. The higher inhibition index observed for rLF alone as compared to LeTx is contrary to the existing knowledge on LF, which explains the requirement of PA dependent endocytosis for its enzymatic activity. Therefore, the plausible existence of PA independent mode of action of LF including direct receptor mediated endocytosis or modulation of signal transduction cascade via unknown means is hypothesized. In silico protein docking analysis of other cellular receptors for any plausibility to play the role of receptor for LF revealed c-Met receptor showing strongest affinity for LF (H bond = 19; Free energy = …

Gait Speed And Confidence Levels In Persons Using 1 And 2 Canes While Walking A 4-M Course, Marion A. Lisenby

Rehabilitation Sciences Faculty Publications

This is the first article that the researcher is aware of that compares walking speed and confidence levels with 1 cane versus 2 canes. An observational study was conducted with 30 participants who had difficulty walking. Gait speed was assessed on a 4-m course with the participants using 1 cane, then 2 canes. Of 30 participants, 28 walked faster and demonstrated improved confidence with 2 canes. Use of 2 canes with gait might be a technique that people want to consider to improve confidence or to improve walking speed, or improve both.

Occupational Therapy And Physiotherapy Education And Workforce In Anglophone Sub-Saharan Africa Countries, Augustine O. Agho, Emmanuel B. John

Rehabilitation Sciences Faculty Publications

Background: Sub-Saharan Africa (SSA) countries are faced with the challenge of educating a critical mass of occupational therapists (OTs) and physiotherapists (PTs) to meet the growing demand for health and rehabilitation services. The World Federation of Occupational Therapy (WFOT) and World Confederation of Physical Therapy (WCPT) have argued for the need of graduate-level training for OTs and PTs for decades. However, very few studies have been conducted to determine the availability of OT and PT training programs and practitioners in SSA countries.

Methods: Initial data were collected and compiled from an extensive literature search conducted using MEDLINE and PubMed to …

The Ability Of The Landing Error Scoring System To Detect Changes In Landing Mechanics: A Critically Appraised Topic, Claire E. Pointer, Tyler D. Reems, Emily M. Hartley, Johanna M. Hoch

Rehabilitation Sciences Faculty Publications

Clinical Question: Is there evidence to suggest that the Landing Error Scoring System (LESS) is able to detect functional changes in landing mechanics in healthy individuals after participation in an injury prevention program (IPP)? Clinical Bottom Line: In a healthy, physically active population, there is strong evidence to support the use of the LESS as an outcome measure for changes in landing mechanics after the implementation of IPPs. Clinicians should consider the LESS as an evaluative tool for measuring the efficacy of IPPs in clinical practice.

Epidemiology Of Knee Sprains In Youth, High School, And Collegiate American Football Players, Daniel R. Clifton, James A. Onate, Eric Schussler, Aristarque Djoko, Thomas P. Dompier, Zachary Y. Kerr

Rehabilitation Sciences Faculty Publications

Context: Assessment of health-related quality of life (HRQOL) after injury is important. Differences in HRQOL between nonathletes and athletes and between injured and uninjured athletes have been demonstrated; however, the evidence has not been synthesized.

Objective: To answer the following questions: (1) Does HRQOL differ among adolescent and collegiate athletes and nonathletes? (2) Does HRQOL differ between injured adolescent and collegiate athletes or between athletes with a history of injury and uninjured athletes or those without a history of injury?

Data Sources: We systematically searched CINAHL, MEDLINE, SPORTDiscus, and PubMed. A hand search of references was also conducted. Study Selection: …

Substance Use Among Transgender Students In California Public Middle And High Schools, Kris Tunac De Pedro, Tamika D. Gilreath, Christopher Jackson, Monica Christina Esqueda

Educational Leadership & Workforce Development Faculty Publications

BACKGROUND: Transgender adolescents face tremendous social stress in families and schools, which often leads to behavioral health disparities. This study assessed whether rates of substance use were higher among transgender adolescents when compared to nontransgender adolescents.

METHODS: This study is a secondary data analysis of the 2013-2015 California Healthy Kids Survey (CHKS) that examines whether rates of substance use are higher among transgender youth when compared to nontransgender youth. Participants included 4778 transgender and 630,200 nontransgender students in middle and high schools in nearly all school districts in California. The study outcomes were lifetime, recent, and in-school use of …