Medicine and Health Sciences Commons^™

Nursing Research Priorities In Critical Care, Pulmonary, And Sleep: International Delphi Survey Of Nurses, Patients, And Caregivers: An Official American Thoracic Society Workshop Report, Maureen George, Carme Hernandez, Sheree Smith, Georgia Narsavage, Mary C. Kapella, Margaretann Carno, Jill L. Guttormson, Rebecca T. Disler, Diana E. Hart, Mary Beth Happ, Zijing Chen, Breanna Hetland, Ana F. Hutchinson, Helga Jonsdottir, Nancy S. Redeker, Hildy Schell-Chaple, Monica Fletcher, Janelle Yorke

College of Nursing Faculty Research and Publications

The objective of this workshop was to determine current nursing research priorities in critical care, adult pulmonary, and sleep conditions through input from consumer (patient, family, and formal and informal caregivers) and nursing experts around the world. Working groups composed of nurses and patients selected potential research priorities based on patient insight and a literature review of patient-reported outcomes, patient-reported experiences, and processes and clinical outcomes in the focal areas. A Delphi consensus approach, using a qualitative survey method to elicit expert opinion from nurses and consumers was conducted. Two rounds of online surveys available in English, Spanish, and Chinese …

Budget Impact Analysis Of Robotic Exoskeleton Use For Locomotor Training Following Spinal Cord Injury In Four Sci Model Systems, Daniel Pinto, Mauricio Garnier-Villarreal, Jason Barbas, Shuo-Hsiu Chang, Susan Charlifue, Edelle C. Field-Fote, Catherine L. Furbish, Candy Tefertiller, Chaithanya K. Mummidisetty, Heather Taylor, Arun Jayaraman, Allen W. Heinemann

College of Nursing Faculty Research and Publications

Background

We know little about the budget impact of integrating robotic exoskeleton over-ground training into therapy services for locomotor training. The purpose of this study was to estimate the budget impact of adding robotic exoskeleton over-ground training to existing locomotor training strategies in the rehabilitation of people with spinal cord injury.

Methods

A Budget Impact Analysis (BIA) was conducted using data provided by four Spinal Cord Injury (SCI) Model Systems rehabilitation hospitals. Hospitals provided estimates of therapy utilization and costs about people with spinal cord injury who participated in locomotor training in the calendar year 2017. Interventions were standard of …

Parent Readiness For Hospital Discharge Scale: Psychometrics And Association With Postdischarge Outcomes, Marianne E. Weiss, Stacee M. Lerret, Rachel Schiffman

College of Nursing Faculty Research and Publications

Introduction The purpose of this study is to validate the Readiness for Hospital Discharge Scale (RHDS) for use with parents of hospitalized children. PedRHDS is a structured tool for a discharge readiness assessment before pediatric discharge. Methods Using combined data from four studies with 417 parents, psychometric testing and item reduction proceeded with principal component analysis for factor structure delineation, Cronbach's alpha for reliability estimation, and regression analysis for predictive validity. Results A 23-item PedRHDS retained the a priori factor structure. Reliability ranged from 0.73 to 0.85 for the 23-item and 10- and 8-item short scales. PedRHDS (all forms) was …

Infant Illness Severity And Perinatal Post-Traumatic Stress Disorder After Discharge From The Neonatal Intensive Care Unit, Kathryn J. Malin, Teresa S. Johnson, Sarah Mcandrew, Jacqueline Westerdahl, Jonathan Leuthner, Joanne Lagatta

College of Nursing Faculty Research and Publications

Background

Risk factors for perinatal posttraumatic stress disorder (PTSD) among parents of an infant in the NICU have varied in previous literature. The relationships between perception of illness severity and objective measures of illness severity with PTSD are not well understood.

Aims

To determine if PTSD among parents after an infant NICU discharge can be predicted by 1) objective measures of infant illness severity or 2) perceptions of infant illness severity.

Study design

A prospective, observational study.

Subjects

Parent/infant dyads who were in the NICU for ≥14 days.

Outcome measures

Objective measures of illness severity were obtained from the electronic …

Clinical Nurses' Perspectives On Discharge Practice Changes From Participating In A Translational Research Study, Kathleen L. Bobay, Regina Conway-Philips, Ronda G. Hughes, Linda L. Costa, Sarah J. Bahr, Danielle M. Siclovan, Susan A. Nuccio, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Aim

To describe clinical nurses' experiences with practice change associated with participation in a multi‐site nursing translational research study implementing new protocols for hospital discharge readiness assessment.

Background

Nurses' participation in translational research studies provides an opportunity to evaluate how implementation of new nursing interventions affects care processes within a local context. These insights can provide information that leads to successful adoption and sustainability of the intervention.

Methods

Semi‐structured focus groups from 30 of 33 participating study hospitals lead by team nurse researchers.

Results

Nurses reported improved and earlier awareness of patients' discharge needs, changes in discharge practices, greater patient/family …

Feasibility And Acceptability Of A Game-Based Symptom-Reporting App For Children With Cancer: Perspectives Of Children And Parents, Lauri Linder, Amy Rose Newman, Kristin Stegenga, Yin-Shun Chiu, Sarah E. Wawrzynski, Heidi Kramer, Charlene Weir, Scott Narus, Roger Altizer

College of Nursing Faculty Research and Publications

Background

Children with cancer have difficulty identifying and describing the multiple symptoms they experience during hospitalization and between clinical encounters. Mobile health resources, including apps, are potential solutions to support child-centric symptom reporting. This study evaluated the feasibility and acceptability of a newly developed game-based symptom-reporting app for school-age children with cancer.

Procedure

Nineteen school-age children (6–12 years of age) receiving treatment for cancer at a COG institution in the Intermountain West of the United States used a game-based symptom-reporting app between clinical visits. Feasibility was evaluated through a summary of actual days of app use and interaction with each …

Living The Manatt Report: Advancing The Future Of Nursing Through Joint Academic Appointments, Jennifer K. Pfister, Jill C. Kuester, Katie Mcdermott, Leslie Talbert, Christine A. Schindler

College of Nursing Faculty Research and Publications

In 2016, the American Association of Colleges of Nursing published the Manatt Report which outlines recommendations to address the future of academic nursing. This report asserts that in order to influence the direction of healthcare, academic nursing needs to partner with academic health centers in leadership positions, embrace current clinical practice, and prioritize research. The following paper details the successful implementation of joint academic appointments between a college of nursing and a medical college. Joint appointments have formalized the role of clinician-educator, brought current clinical knowledge to academia, and allowed for protected academic time that is focused on enhancing the …

Blood Flow Improvement Trial: Design And Enrollment Developing Topics, Maiya F. Macalpine, Margo B. Heston, Julian M. Gaitán, Ozioma C. Okonkwo, Barbara B. Bendlin, Kimberlee A. Gretebeck, Randall J. Gretebeck

College of Nursing Faculty Research and Publications

Background

Midlife insulin resistance (IR) has previously been shown to be associated with lower cerebral blood flow (CBF), and is a potentially modifiable risk factor for dementia. The Blood Flow Improvement Trial (BFiT), NCT03117829 , tested a 12 week carbohydrate restricted diet (CRD) and exercise behavioral intervention to reverse IR, and aimed to 1) determine the extent to which improving or normalizing glucose homeostasis improves CBF and cognitive function in individuals with IR, 2) determine whether participants continue to maintain improved or normalized glycemic control for 6 months, and 3) determine changes in the human metabolome as individuals improve or …

Circuit Development In The Master Clock Network Of Mammals, Vania Carmonia-Alcocer, Kayla Rohr, Deborah A.M. Joye, Jennifer A. Evans

Biomedical Sciences Faculty Research and Publications

Daily rhythms are generated by the circadian timekeeping system, which is orchestrated by the master circadian clock in the suprachiasmatic nucleus (SCN) of mammals. Circadian timekeeping is endogenous and does not require exposure to external cues during development. Nevertheless, the circadian system is not fully formed at birth in many mammalian species and it is important to understand how SCN development can affect the function of the circadian system in adulthood. The purpose of the current review is to discuss the ontogeny of cellular and circuit function in the SCN, with a focus on work performed in model rodent species …

In Vitro Evaluation Of Different Protocols For Preventing Microleakage Of Fissure Sealants Placed Following Saliva Contamination, Hayrunnisa Şimşek, A. Rüya Yazici, H. Cem Güngör

School of Dentistry Faculty Research and Publications

Purpose: To evaluate the effect of different enamel conditioning protocols and their re-application on the microleakage of fissure sealants placed following saliva contamination.

Study design: The study included 156 human third molars in 16 subgroups (2×4×2) under two main groups (sealant type): Group A- hydrophobic resin sealant, 3M Clinpro^™ Sealant; Group B- hydrophilic resin sealant, Ultraseal XT Hydro. Each group was then divided according to the type of surface conditioning; 1- Er,Cr:YSSG laser etching, 2- acid-etching, 3- acid-etching+etch-and-rinse adhesive (Prime&Bond^® One Select) and 4- self-etching adhesive (Clearfil^™SE Bond). After contaminating the conditioned occlusal enamel surfaces with …

Multitarget Stool Dna Testing For The Prevention Of Colon Cancer: Outcomes In A Large Integrated Healthcare System, Nimish Vakil, Kristin Ciezki, Nadia Huq, Maharaj Singh

School of Dentistry Faculty Research and Publications

Background and Aims

Multitarget stool DNA (MT-sDNA) testing is used in primary care as a screening test for colon cancer. Test effectiveness and patient compliance were examined in clinical practice.

Methods

We assessed outcomes of MT-sDNA testing in a cohort study conducted in a large integrated healthcare system comprising 15 hospitals and 150 outpatient clinics using advanced electronic data capture (Clarity2 [Epic, Verona, Wisc, USA] and REDCap [Encinitas, Calif, USA]) followed by manual chart review to confirm MT-sDNA test results and to monitor the outcomes of subsequent colonoscopy.

Results

A total of 6835 MT-sDNA tests were performed over 1 year …

Hydrogen Peroxide Preconditioning Promotes Protective Effects Of Umbilical Cord Vein Mesenchymal Stem Cells In Experimental Pulmonary Fibrosis, Tayebeh Mahmoudi, Kamal Abdolmohammadi, Hamed Bashiri, Mehdi Mohammadi, Mohammad Jafar Rezaie, Fardin Fathi, Shohreh Fakhari, Mohammad Ali Rezaee, Ali Jalili, Mohammad Reza Rahmani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder with few available treatments. Mesenchymal stem cell therapy (MSCT), an innovative approach, has high therapeutic potential when used to treat IPF. According to recent data, preconditioning of MSCs can improve their therapeutic effects. Our research focuses on investigating the anti-inflammatory and antifibrotic effects of H₂O₂-preconditioned MSCs (p-MSCs) on mice with bleomycin-induced pulmonary fibrosis (PF).

Methods

Eight-week-old male C57BL/6 mice were induced with PF by intratracheal (IT) instillation of bleomycin (4 U/kg). Human umbilical cord vein-derived MSCs (hUCV-MSCs) were isolated and exposed to a sub-lethal concentration (15 …

Social And Psychological Factors Associated With Health Care Transition For Young Adults Living With Sickle Cell Disease, Dora L. Clayton-Jones, Nadine Matthie, Marsha Treadwell, Joshua Field, Amy Mager, Rachel Sawdy, Safiya George Dalmida, Cynthia Leonard, Kathryn L. Koch, Kristin Haglund

College of Nursing Faculty Research and Publications

Introduction: Due to advances in disease management, mortality rates in children with sickle cell disease (SCD) have decreased. However, mortality rates for young adults (YA) increased, and understanding of social and psychological factors is critical. The aim of this study was to explore factors associated with health care transition experiences for YA with SCD.

Method: This was a qualitative descriptive study. A 45-minute semistructured interview was conducted with 13 YA (M = 21.5 years, SD = 1.73).

Results: Results suggest that social and psychological factors and self-management experiences influence health care transition. Eight themes emerged: “need for accessible support”; “early …

Moving Toward Non-Transcription Based Discourse Analysis In Stable And Progressive Aphasia, Sarah Grace Dalton, H. Isabel Hubbard, Jessica D. Richardson

Speech Pathology and Audiology Faculty Research and Publications

Measurement of communication ability at the discourse level holds promise for predicting how well persons with stable (e.g., stroke-induced), or progressive aphasia navigate everyday communicative interactions. However, barriers to the clinical utilization of discourse measures have persisted. Recent advancements in the standardization of elicitation protocols and the existence of large databases for development of normative references have begun to address some of these barriers. Still, time remains a consistently reported barrier by clinicians. Non-transcription based discourse measurement would reduce the time required for discourse analysis, making clinical utilization a reality. The purpose of this article is to present evidence regarding …

The Nurse’S Role In Prognosis-Related Communication In Pediatric Oncology Nursing Practice, Amy Rose Newman, Lauri Linder, Kristin Haglund

College of Nursing Faculty Research and Publications

The experiences of pediatric oncology nurses with prognosis-related communication (PRC) remain largely unknown. The purpose of this article is to report results of focus groups wherein 15 pediatric oncology nurses from three Midwestern pediatric cancer programs provided descriptions of PRC and how they experience PRC within their daily practice. Data from focus groups were analyzed via an interpretive descriptive approach, which resulted in three themes: (1) nurses’ operational definition of PRC, (2) nurses’ roles in PRC, and (3) nurses’ preparation for engagement in PRC. From discussions within the focus groups, nurses recognized that PRC occurs across a continuum. Nurses distinguished …

Advanced Practice Providers: How Do We Improve Their Organizational Engagement?, Molly Condit, Paula Hafeman

College of Nursing Faculty Research and Publications

Advanced practice providers (APPs) are integral members of the multidisciplinary health care team, providing access to high quality and cost-effective patient care. Despite the consistent increase in demand for APPs, these practitioners often lack role clarity, frequently resulting in poor job satisfaction and retention. Establishing an advanced practice provider council within organizations is a positive step in providing APPs with a platform for increasing their visibility, peer support, and decision-making power, thereby improving their engagement within the organization.

Efficacy Of Natural Family Planning Methods, Richard J. Fehring

College of Nursing Faculty Research and Publications

No abstract provided.

Effects Of Women’S Weight Changes On Adverse Outcomes In A Second Pregnancy, Marianne E. Weiss, Olga Yakusheva, Kandice A. Kapinos

College of Nursing Faculty Research and Publications

Objective

To estimate the effects of women’s weight changes in four sequential perinatal periods across first and second pregnancies (pregravid, first gestation, interpregnancy, second gestation) on adverse maternal and neonatal outcomes in the second pregnancy while accounting for interdependencies in weight across the four periods (Aim 1) and to test the influence of the sequential path of weight changes through the four perinatal periods of risk on maternal and neonatal outcomes in the second pregnancy (Aim 2).

Design

Secondary data analysis.

Setting

Thirty-one Wisconsin hospitals.

Sample

Women with 24,795 linked records from first and second births from 2006 through 2013. …

Feasibility And Acceptability Of A Self-Report Activity Diary In Families Of Children With And Without Special Needs, Bethany Forseth, Paula E. Papanek, Linda Bandini, Dale A. Schoeller, Andrea Moosreiner, Kathleen J. Sawing, Kimberley Zvara, Michael Fendrich, Michele Polfuss

Exercise Science Faculty Research and Publications

This study was conducted to examine the feasibility and acceptability of a self-report activity diary completed by parents and older children to assess the child's daily activity in children with and without special needs. The study included 36 child/parent dyads stratified by child age and diagnosis. Parents (n = 36) and children ≥13 years (n = 12) were asked to report on the child's daily activity using an activity diary. Feasibility was determined based on successfully returned diaries and acceptability via post-study interview. Activity diaries were submitted by 94% of the parents and 100% of the children, with 83% and …

A Glassy Carbon Electrode Modified With Reduced Graphene Oxide And Gold Nanoparticles For Electrochemical Aptasensing Of Lipopolysaccharides From Escherichia Coli Bacteria, Mehrab Pourmadadi, Javad Shabani Shayeh, Meisam Omidi, Fatemeh Yazdian, Masoud Alebouyeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

An electrochemical aptasensor is described for the voltammetric determination of lipopolysaccharide (LPS) from Escherichia coli 055:B5. Aptamer chains were immobilized on the surface of a glassy carbon electrode (GCE) via reduced graphene oxide and gold nanoparticles (RGO/AuNPs). Fast Fourier transform infrared, X-ray diffraction and transmission electron microscopy were used to characterize the nanomaterials. Cyclic voltammetry, square wave voltammetry and electrochemical impedance spectroscopy were used to characterize the modified GCE. The results show that the modified electrode has a good selectivity for LPS over other biomolecules. The hexacyanoferrate redox system, typically operated at around 0.3 V (vs. Ag/AgCl) is used as …

Seasonal Plasticity In GabaA Signaling Is Necessary For Restoring Phase Synchrony In The Master Circadian Clock Network, Kayla Rohr, Harshida Pancholi, Shabi Haider, Christopher Karow, David Modert, Nicholas J. Raddatz, Jennifer A. Evans

Biomedical Sciences Faculty Research and Publications

Annual changes in the environment threaten survival, and numerous biological processes in mammals adjust to this challenge via seasonal encoding by the suprachiasmatic nucleus (SCN). To tune behavior according to day length, SCN neurons display unified rhythms with synchronous phasing when days are short, but will divide into two sub-clusters when days are long. The transition between SCN states is critical for maintaining behavioral responses to seasonal change, but the mechanisms regulating this form of neuroplasticity remain unclear. Here we identify that a switch in chloride transport and GABA_A signaling is critical for maintaining state plasticity in the SCN …

Exploration Of Mindfulness Among Ethnic Minority Undergraduate Nursing Students, Amber Young-Brice, Kristina Dreifuerst

College of Nursing Faculty Research and Publications

Background

Meeting projected needs for ethnically diverse nurses depends on a strong pipeline of diverse students within nursing programs. Colleges assume students readily navigate the university; however, this may not be the reality especially among ethnic minority students.

Purpose

The purpose was to explore the concept of mindfulness among ethnic minority nursing students. Exploring mindfulness, and a lack thereof, may provide strategies for overcoming challenges ethnic minority students experience in prelicensure nursing programs.

Methods

A qualitative study using thematic analysis of semistructured in-depth interviews was conducted with 20 ethnic minority undergraduate nursing students.

Results

Themes that emerged reveal positive associations …

Racism, Bias, And Discrimination As Modifiable Barriers To Breastfeeding For African American Women: A Scoping Review Of The Literature, Karen Marie Robinson, Alissa Fial, Lisa Hanson

College of Nursing Faculty Research and Publications

Introduction

Although breastfeeding has been shown to improve health outcomes for infants, African American women initiate and continue breastfeeding at lower rates than women from other racial groups. This scoping review was conducted to assess the effect racism, bias, and discrimination have on breastfeeding care, support, and outcomes for African American women.

Methods

A scoping review was performed of the literature published between January 2010 through December 2019 using databases MEDLINE via PubMed, CINAHL, Cochrane Library, PsycINFO, and Sociological Abstracts. Studies that examined racism, bias, or discrimination with breastfeeding as an outcome were included. After a review of titles and …

Energy Cost Of Slow And Normal Gait Speeds In Low And Normally Functioning Adults, Taylor W. Rowley, Chi Cho, Ann M. Swartz, John Staudenmayer, Allison S. Hyngstrom, Kevin G. Keenan, Whitney A. Welch, Scott J. Strath

Physical Therapy Faculty Research and Publications

Objective

Slow walking speed paired with increased energy cost is a strong predictor for mortality and disability in older adults but has yet to be examined in a heterogeneous sample (ie, age, sex, disease status). The aim of this study was to examine energy cost of slow and normal walking speeds among low- and normal-functioning adults.

Design

Adults aged 20–90 yrs were recruited for this study. Participants completed a 10-m functional walk test at a self-selected normal walking speed and were categorized as low functioning or normal functioning based on expected age- and sex-adjusted average gait speed. Participants completed two …

Priority Symptoms, Causes, And Self-Management Strategies Reported By Ayas With Cancer, Lauri Linder, Kristin Stegenga, Jeanne Erickson, Suzanne Ameringer, Amy Rose Newman, Yin-Shun Chiu, Catherine Fiona Macpherson

College of Nursing Faculty Research and Publications

Context

Cancer and symptom experiences of adolescents and young adults (AYAs) with cancer can be highly variable, creating challenges for clinicians and researchers who seek to optimize AYAs' health outcomes. Understanding the heuristics AYAs use to designate priority symptoms can provide insight into the meaning they assign to their symptoms and self-management behaviors.

Objectives

This study described the frequency and characteristics of priority symptoms. It qualitatively explored reasons for a symptom's designation as a priority symptom, perceived causes of priority symptoms, and strategies AYAs use to manage priority symptoms.

Methods

Participants in this single-group, longitudinal study reported symptoms using a …

Time To Move: Shifting The Icu Paradigm To Improve Outcomes For Survivors Of Critical Illness, Jill L. Guttormson, Natalie S. Mcandrew

College of Nursing Faculty Research and Publications

No abstract provided.

Exploration Of Mindfulness Among Ethnic Minority Undergraduate Nursing Students, Amber Young-Brice, Kristina Dreifuerst

College of Nursing Faculty Research and Publications

Background. Meeting projected needs for ethnically diverse nurses depends on a strong pipeline of diverse students within nursing programs. Colleges assume students readily navigate the university; however, this may not be the reality especially among ethnic minority students.

Purpose. The purpose was to explore the concept of mindfulness among ethnic minority nursing students. Exploring mindfulness, and a lack thereof, may provide strategies for overcoming challenges ethnic minority students experience in prelicensure nursing programs.

Methods. A qualitative study using thematic analysis of semistructured in-depth interviews was conducted with 20 ethnic minority undergraduate nursing students.

Results. Themes that emerged reveal positive associations …

Long-Term Health-Related Quality Of Life Of Adult Patients Treated With Extracorporeal Membrane Oxygenation (Ecmo): An Integrative Review, Krista A. Knudson, Carolina M. Gustafson, Lois S. Sadler, Robin Whittemore, Nancy S. Redeker, Laura K. Andrews, Abeel A. Mangi, Marjorie Funk

College of Nursing Faculty Research and Publications

Background: Extracorporeal membarane oxygenation (ECMO), a rescue  treatment for patients with severe pulmonary and/or cardiac dysfunction, is increasingly being used worldwide. A better understanding of long-term health-related quality of life (HRQOL) is needed.

Objective: To synthesize research on long-term (at least 6 months post-ECMO) HRQOL of adults treated with ECMO.

Methods: In this integrative review, we searched 3 electronic databases and did a hand search of relevant journals for articles published 2000–2019, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results: Thirty-one studies, representing 913 patients treated with ECMO, were included. Long-term HRQOL was slightly …

Design Of A New 3d‐Printed Joint Plug, Lobat Tayebi, Zhanfeng Cui, Hua Ye

School of Dentistry Faculty Research and Publications

This paper introduces a kit of parts as a novel three‐dimensional (3D)–printed joint plug, in which each of the parts function cooperatively to treat cartilage damage in joints of the human body (e.g., hips, wrists, elbow, knee, and ankle). Three required and one optional parts are involved in this plug. The first part is a 3D‐printed hard scaffold (bone portion) to accommodate bone cells, and the second is a 3D‐printed soft scaffold (cartilage portion) overlying the bone portion to accommodate chondrocytes. The third part of joint plug is a permeable membrane, termed film, to cover the entire plug to provide …

Synthesis And Application Of Ce-Doped Tio2 Nanoparticles Loaded On Activated Carbon For Ultrasound-Assisted Adsorption Of Basic Red 46 Dye, Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram, Fatemah Mehrabi, Ali Akbar Bazrafshan, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Ce was doped on TiO₂ nanoparticles (NPs), and this association was loaded on activated carbon (Ce-TiO₂-NPs-AC). The characterization was completed by FE-SEM, TEM, and XRD, and finally these NPs were used for the ultrasonic-assisted adsorption of Basic Red 46 (BR 46) from aqueous solution. An experimental model suggested by the central composite design (CCD)—as a branch of response surface methodology (RSM)—provides insight into the influence of variables, such as BR 46 concentration, pH, adsorbent mass, and sonication time, on BR 46 removal. Experimental results revealed that setting conditions at 25 mg L⁻¹ of BR 46, pH …