Medicine and Health Sciences Commons^™

Evidence For The Multiple Hits Genetic Theory For Inherited Language Impairment: A Case Study, Tracy M. Centanni, Jordan R. Green, Jenya Iuzzini-Seigel, Christopher W, Bartlett, Tiffany P. Hogan

Speech Pathology and Audiology Faculty Research and Publications

Communication disorders have complex genetic origins, with constellations of relevant gene markers that vary across individuals. Some genetic variants are present in healthy individuals as well as those affected by developmental disorders. Growing evidence suggests that some variants may increase susceptibility to these disorders in the presence of other pathogenic gene mutations. In the current study, we describe eight children with specific language impairment and four of these children had a copy number variant in one of these potential susceptibility regions on chromosome 15. Three of these four children also had variants in other genes previously associated with language impairment. …

Sex Differences In Arm Muscle Fatigability With Cognitive Demand In Older Adults, Hugo M. Pereira, Vincent C. Spears, Bonnie Schlinder-Delap, Tejin Yoon, April L. Harkins, Kristy A. Nielson, Marie K. Hoeger Bement, Sandra K. Hunter

Physical Therapy Faculty Research and Publications

Background

Muscle fatigability can increase when a stressful, cognitively demanding task is imposed during a low-force fatiguing contraction with the arm muscles, especially in women. Whether this occurs among older adults (> 60 years) is currently unknown.

Questions/purposes

We aimed to determine if higher cognitive demands, stratified by sex, increased fatigability in older adults (> 60 years). Secondarily, we assessed if varying cognitive demand resulted in decreased steadiness and was explained by anxiety or cortisol levels.

Methods

Seventeen older women (70 ± 6 years) and 13 older men (71 ± 5 years) performed a sustained, isometric, fatiguing contraction at 20% …

Combined Unilateral Blockade Of Cholinergic, Peptidergic, And Serotonergic Receptors In The Ventral Respiratory Column Does Not Affect Breathing In Awake Or Sleeping Goats, Clarissa Muere, Suzanne Neumueller, Samantha Olesiak, Justin Robert Miller, Thomas Langer, Matthew Hodges, Lawrence Pan, Hubert Forster

Physical Therapy Faculty Research and Publications

Previous work in intact awake and sleeping goats has found that unilateral blockade of excitatory inputs in the ventral respiratory column (VRC) elicits changes in the concentrations of multiple neurochemicals, including serotonin (5-HT), substance P, glycine, and GABA, while increasing or having no effect on breathing. These findings are consistent with the concept of interdependence between neuromodulators, whereby attenuation of one modulator elicits compensatory changes in other modulators to maintain breathing. Because there is a large degree of redundancy and multiplicity of excitatory inputs to the VRC, we herein tested the hypothesis that combined unilateral blockade of muscarinic acetylcholine (mACh), …

Predictors Of Engagement In Postpartum Weight Self-Management Behaviours In The First 12 Weeks After Birth, Jennifer M. Ohlendorf, Marianne E. Weiss, Debra L. Oswald

College of Nursing Faculty Research and Publications

Aim

To explore factors that influence postpartum weight self-management behaviours. Transitions Theory and the Integrated Theory of Health Behaviour Change guided selection of variables. Transition conditions, level of patient activation and social facilitation were examined for association with postpartum weight self-management behaviours.

Background

Retention of pregnancy weight increases risk of overweight and obesity later in life. Little is known about what women do to self-manage return to pre-pregnant weight and how providers can influence their behaviours.

Design

Prospective, longitudinal, correlational.

Methods

Data collection occurred from March through October, 2013. One hundred and twenty-four women completed surveys during postpartum hospitalization; telephone …

Losartan Treatment Attenuates Tumor-Induced Myocardial Dysfunction, Sarah C.W. Stevens, Markus Velten, Dane J. Youtz, Yvonne Clark, Runfeng Jing, Peter J. Reiser, Sabahattin Bicer, Raymond D. Devine, Donna O. Mccarthy, Loren E. Wold

College of Nursing Faculty Research and Publications

Fatigue and muscle wasting are common symptoms experienced by cancer patients. Data from animal models demonstrate that angiotensin is involved in tumor-induced muscle wasting, and that tumor growth can independently affect myocardial function, which could contribute to fatigue in cancer patients. In clinical studies, inhibitors of angiotensin converting enzyme (ACE) can prevent the development of chemotherapy-induced cardiovascular dysfunction, suggesting a mechanistic role for the renin–angiotensin–aldosterone system (RAAS). In the present study, we investigated whether an angiotensin (AT) 1-receptor antagonist could prevent the development of tumor-associated myocardial dysfunction. Methods and results: Colon26 adenocarcinoma (c26) cells were implanted into female CD2F1 mice …

The Influence Of Contraception, Abortion, And Natural Family Planning On Divorce Rates As Found In The 2006–2010 National Survey Of Family Growth, Richard J. Fehring

College of Nursing Faculty Research and Publications

The purpose of this study was to determine the influence of contraception, abortion, and natural family planning (NFP) on divorce rates of US women of reproductive age. The variables of importance of religion and frequency of church attendance were also included in the analysis. The study involved 5,530 reproductive age women in the (2006–2010) National Survey of Family Growth who indicate that they were ever married. Among the women who ever used NFP only 9.6 percent were currently divorced compared with the 14.4 percent who were currently divorced among the women who never used NFP (x² = 5.34, …

Undergraduate Nursing Students’ Attitudes Toward Mental Health Nursing, Vipavee Thongpriwan, Susan E. Leuck, Rhonda L. Powell, Staci Young, Suzanne Schuler, Ronda G. Hughes

College of Nursing Faculty Research and Publications

Objectives: The purpose of this study was to describe undergraduate nursing students’ attitudes toward mental health nursing and how these attitudes influenced their professional career choices in mental health nursing.

Design: A descriptive, online survey was utilized to examine students’ perceptions of mental health nursing. A total of 229 junior and senior nursing students were recruited from eight nursing colleges in Midwestern United States to participate in this survey.

Results: Students of different ages, genders, ethnicities, and nursing programs did not report significantly different perceptions of: (a) knowledge of mental illness; (b) negative stereotypes; (c) interest in mental health nursing …

Customized Occlusal Reduction Guide Made From A Thermoplastic Sheet, Seok-Hwan Cho, William W. Nagy

School of Dentistry Faculty Research and Publications

No abstract provided.

The Effect Of Antagonist Muscle Sensory Input On Force Regulation, Tanya Onushko, Brian D. Schmit, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

The purpose of this study was to understand how stretch-related sensory feedback from an antagonist muscle affects agonist muscle output at different contraction levels in healthy adults. Ten young (25.3 ± 2.4 years), healthy subjects performed constant isometric knee flexion contractions (agonist) at 6 torque levels: 5%, 10%, 15%, 20%, 30%, and 40% of their maximal voluntary contraction. For half of the trials, subjects received patellar tendon taps (antagonist sensory feedback) during the contraction. We compared error in targeted knee flexion torque and hamstring muscle activity, with and without patellar tendon tapping, across the 6 torque levels. At lower torque …

Changes In Composite Toxicity Following Exposure To Pulp Capping Materials, Audra Long

Master's Theses (2009 -)

Introduction: Direct pulp capping involves placing a material over the exposed pulp in order to maintain its vitality. For decades, calcium hydroxide (CH) has served as the gold standard for this purpose, but its toxicity to the pulp may negatively impact treatment outcomes. Mineral Trioxide Aggregate (MTA) has become a popular alternative based partly on its excellent biocompatibility. Pulp-capped teeth are often restored with highly toxic composite materials, but the pulp capping material’s ability to alter these toxic effects has never been investigated. The purpose of this in vitro study is to determine the effects of Dycal, a CH-based cement, …

The Direct Effect Of Low-Magnitude High-Frequency Mechanical Vibration On Osteoclast Formation From Raw267.4 Monocytes, Maxwell Antonio Abraham

Master's Theses (2009 -)

Low-magnitude high-frequency (LMHF) mechanical vibration has been demonstrated to enhance bone formation possibly through inhibition of osteoclastogenesis of bone. Earlier research has demonstrated osteoclast formation from RAW264.7 monocytes was inhibited by a chewing cycle mimicking vibration through inhibition of dendritic cell-specific transmembrane protein (DC-STAMP). We hypothesize that application of LMHF mechanical vibration directly inhibits osteoclast formation from RAW264.7 monocytes in a frequency dependent manner. RAW264.7 monocytes (ATCC) were cultured in alpha minimal essential medium (MEM) with 10% fetal bovine serum (FBS ) and 1% Pen/Strep at 37°C and 5% CO2. The cells were seeded at a density of 2000 cells/well …

Influence Of Fluoride And Stress On The Electrochemical Properties Of Nickel-Titanium Coils, Ashley Barnes

Master's Theses (2009 -)

The aim of this study was to examine the effects of fluoride and stress on the electrochemical properties of nickel-titanium coils. Forty Dentsply GAC NiTi coils were divided into four groups of ten and individually tested. Twenty coils were placed in a solution of artificial saliva, where ten of the twenty were compressed and the other ten were not stressed. The other twenty coils were placed in a 1500 ppm NaF solution, where ten were compressed and ten were not. The coils were connected to a computer driven potentiostat and three tests were conducted: open circuit potential monitoring for 2 …

Influence Of Fluoride And Stress On The Mechanical Properties Of Nickel-Titanium Coils, Jennifer Ann Fehrman Roloff

Master's Theses (2009 -)

Objective: The objective of this study was to determine the influence of fluoride and stress on the mechanical properties of nickel-titanium open coil springs. Materials and Methods: Sentalloy nickel-titanium open coil springs (15 mm length) were divided into five groups. A control group was tested mechanically in as-received condition. The other four experimental groups were exposed to artificial saliva (Fusayama-Meyer solution) at 37oC for 12 weeks in a 2x2 factorial design with fluoride exposure and stress (compression) as the two factors. Those springs which were under compression were held at 5 mm in length for the entirety of the testing …

Mechanical Properties And Patient Perceptions Of Commonly Used Clear Aligner Systems As-Received And After Clinical Use, Lauren Evan Montoure Teske

Master's Theses (2009 -)

Background/Objectives: This study aimed to investigate the viscoelastic properties of two clear aligner systems, Invisalign (Align Technology, Inc, Santa Clara, CA, USA) and Simpli5 (Allesee Orthodontic Appliances, Sturtevant, WI, USA), and determine if there was a difference after use. A survey assessed patients’ perceptions of the aligner material and post-treatment satisfaction. Materials/Methods: Mandibular aligners were collected from two patients after 2-3 weeks of use (n=6). Duplicate, unused aligners were obtained for each patient (n=6). Dynamic mechanical analysis (DMA) characterized the viscoelastic properties of the materials. Three tests were done on separate specimens: frequency scan (0.1-10 Hz under 25 μm displacement …

Thermomechanical Characterization Of Variable Force Niti Orthodontic Archwires, Anjali Sudershan Krishan Mehta

Master's Theses (2009 -)

ABSTRACT THERMOMECHANICAL CHARACTERIZATION OF VARIABLE FORCE NITI ORTHODONTIC ARCHWIRES Anjali Mehta, BDS MDS Marquette University, 2015 Introduction: Nickel-Titanium (NiTi) archwires, due to their properties of superelasticity and shape memory, have been extensively used in orthodontic mechanotherapy. However, one of the shortcomings of these wires is that they deliver constant forces across the entire arch. The amount of force needed to move a tooth is a function of the surface area of the tooth and its supporting bone; and is lesser for single rooted anterior teeth compared to larger molars. The introduction of heat treatment of NiTi wires and the influence …

Psychometric Properties Of The Family Caregiver Delirium Knowledge Questionnaire, Margaret J. Bull, Jennifer M. Sjostedt, Lesley Boaz, Debra L. Oswald

College of Nursing Faculty Research and Publications

A valid, reliable measure of family caregivers’ knowledge about delirium was not located in the literature; such an instrument is essential to assess learning needs and outcomes of education provided. The purpose of the current study was to (a) develop a family Caregiver Delirium Knowledge Questionnaire (CDKQ) based on the Symptom Interpretation Model; and (b) establish validity and reliability of the measure. The 19-item CDKQ was developed and administered to 164 family caregivers for community-dwelling older adults. Descriptive statistics were examined for all variables. Psychometric testing included confirmatory factor analysis, item-to-total correlations, and internal consistency reliability. A three-factor model provided …

Emerging Areas Of Nursing Science And Phd Education For The 21St Century: Response To Commentaries, Susan J. Henly, Donna O. Mccarthy, Jean F. Wyman, Anna C. Alt-White, Patricia W. Stone, Ann Marie Mccarthy, Nancy S. Redeker, Jacqueline Dunbar-Jacob, Marita Titler, Marita G. Titler, Yvette P. Conley, Margaret M. Heitkemper, Shirley M. Moore

College of Nursing Faculty Research and Publications

We respond to commentaries from the American Academy of Nursing, the American Association of Colleges of Nursing, and the National Institute of Nursing Research on our thoughts about integrating emerging areas of science into nursing PhD programs. We identify areas of agreement and focus our response on cross-cutting issues arising from cautions about the unique focus of nursing science and how best to proceed with incorporation of emerging areas of science into nursing PhD programs.

Emerging Areas Of Science: Recommendations For Nursing Science Education From The Council For The Advancement Of Nursing Science Idea Festival, Susan J. Henly, Donna O. Mccarthy, Jean F. Wyman, Margaret M. Heitkemper, Nancy S. Redeker, Marita Titler, Ann Marie Mccarthy, Patricia W. Stone, Shirley M. Moore, Anna C. Alt-White, Yvette P. Conley

College of Nursing Faculty Research and Publications

The Council for the Advancement of Nursing Science aims to “facilitate and recognize life-long nursing science career development” as an important part of its mission. In light of fast-paced advances in science and technology that are inspiring new questions and methods of investigation in the health sciences, the Council for the Advancement of Nursing Science convened the Idea Festival for Nursing Science Education and appointed the Idea Festival Advisory Committee (IFAC) to stimulate dialogue about linking PhD education with a renewed vision for preparation of the next generation of nursing scientists. Building on the 2005 National Research Council report Advancing …

Integrating Emerging Areas Of Nursing Science Into Phd Programs, Susan J. Henly, Donna O. Mccarthy, Jean F. Wyman, Patricia W. Stone, Nancy S. Redeker, Ann Marie Mccarthy, Jacqueline Dunbar-Jacob, Marita Titler, Shirley M. Moore, Margaret M. Heitkemper, Yvette P. Conley

College of Nursing Faculty Research and Publications

The Council for the Advancement of Nursing Science aims to “facilitate and recognize life-long nursing science career development” as an important part of its mission. In light of fast-paced advances in science and technology that are inspiring new questions and methods of investigation in the health sciences, the Council for the Advancement of Nursing Science convened the Idea Festival for Nursing Science Education and appointed the Idea Festival Advisory Committee to stimulate dialogue about linking PhD education with a renewed vision for preparation of the next generation of nursing scientists. Building on the 2010 American Association of Colleges of Nursing …

Educating Future Nursing Scientists: Recommendations For Integrating Omics Content In Phd Programs, Margaret M. Heitkemper, Donna O. Mccarthy, Cindy M. Anderson, Elizabeth J. Corwin, Sandra Daack-Hirsch, Susan G. Dorsey, Katherine E. Gregory, Maureen W. Groer, Susan J. Henly, Timothy Landers, Debra E. Lyon, Jacquelyn Y. Taylor, Joachim Voss

College of Nursing Faculty Research and Publications

Preparing the next generation of nursing scientists to conduct high-impact, competitive, sustainable, innovative, and interdisciplinary programs of research requires that the curricula for PhD programs keep pace with emerging areas of knowledge and health care/biomedical science. A field of inquiry that holds great potential to influence our understanding of the underlying biology and mechanisms of health and disease is omics. For the purpose of this article, omics refers to genomics, transcriptomics, proteomics, epigenomics, exposomics, microbiomics, and metabolomics. Traditionally, most PhD programs in schools of nursing do not incorporate this content into their core curricula. As part of the Council for …

Weight Loss Intervention Efficacy Among Black Women, Callie Chiroff, Kristin Haglund

College of Nursing Faculty Research and Publications

Obesity is a complex disease state that has challenged the health of Americans and has become a main concentration in health care. The highest rates of obesity are observed among black women. The purpose of this evidence-based review was to find evidence that specifically examined black women to determine if participation in weight loss interventions led to successful weight loss compared with usual care and control groups. Twelve experimental studies and 4 systematic reviews revealed that interventions contributed to successful weight loss among black women with obesity. However, maintenance of weight loss is an ongoing challenge.

A Survey Of Concerns In End-Of-Life Care: Perspective From Pakistan, Ariba Khan, Maharaj Singh, Sarah Saeed, Arif Siddiqui, Zeba Aziz, Michael Malone

College of Nursing Faculty Research and Publications

Personalized health care that incorporates advance care planning and aligns treatment with patient-centered goals can improve the quality of life of dying individuals and reduce stress, anxiety, and depression in surviving relatives. Although several prognostication indices that address all-cause mortality have been developed for use in elderly inpatients, none have been integrated into the electronic health record (EHR) to automatically identify high-risk individuals and used during interdisciplinary team rounds to identify vulnerable hospitalized adults.3 At Aurora Health Care in Milwaukee, Wisconsin, an automated alert for serious medical illnesses has been programmed into the EHR. Built on previous findings,the alert …

Can The Electronic Health Record Identify Vulnerable Older Adults In Need Of A Palliative Care Assessment In The Hospital Setting?, James D. Hocker, Ariba Khan, Maharaj Singh, Mary Hook, Michelle Simpson, Aaron Malsch, Marsha Vollbrecht, Michael Malone

College of Nursing Faculty Research and Publications

Personalized health care that incorporates advance care planning and aligns treatment with patient-centered goals can improve the quality of life of dying individuals and reduce stress, anxiety, and depression in surviving relatives.1, 2 Although several prognostication indices that address all-cause mortality have been developed for use in elderly inpatients, none have been integrated into the electronic health record (EHR) to automatically identify high-risk individuals and used during interdisciplinary team rounds to identify vulnerable hospitalized adults.3 At Aurora Health Care in Milwaukee, Wisconsin, an automated alert for serious medical illnesses has been programmed into the EHR. Built on previous findings,4 the …

Neural Plasticity In Response To Intervention In Adolescents With Autism Spectrum Disorders, Sheryl Jayne Stevens

Dissertations (1934 -)

Current theories of Autism Spectrum Disorders (ASD) suggest that they may develop from the transactional interaction between biological risk factors and environmental processes (Dawson et al., 2009). Due to the brain’s experience-expectant nature, one’s degree of social exposure may have a significant impact on their brain development and behavioral presentation. In addition to the primary critical neurodevelopmental period identified in early childhood, recent research has demonstrated a second period of substantial neurodevelopment during the adolescent period (Sisk & Foster, 2004). This study investigated the neural and behavioral impact of participation in an empirically validated behavioral intervention (The Program for the …

Stay-At-Home-Fathers Navigating Depression: A Consensual Qualitative Research Study, William Douglas Meyers Caperton

Dissertations (1934 -)

Evidence suggests that the practices through which men are socialized to become masculine may serve both to restrict their potential in ways that lead to psychological distress, and also to restrict the ways in which they respond to such distress (Addis & Mahalik, 2003; Mahalik, Good, Tager, Levant, & Mackowiak, 2012; O’Neil, 2008). While we are beginning to understand masculine depression (Cochran & Rabinowitz, 2000; Magovcevic & Addis, 2008) and paternal depression (Paulson & Bazemore, 2010; Ramachandani & Psychogiou, 2009), almost nothing is known about how SAHFs experience depression, nor their experiences and beliefs regarding help-seeking and psychotherapy. The trend …

Role Of Shared Care In The Relationship Between Depressive Symptoms And Self-Care In Patients With Heart Failure, Susan Cole

Dissertations (1934 -)

Heart failure (HF) is a chronic condition affecting over 5 million Americans. Heart failure accounts for over 32 billion dollars in total cost each year, and is the most common cause of hospitalization for persons 65 years of age or older. Patients with HF experience poor self-care, are at risk for depressive symptoms, and have high rates of 30-day hospital readmissions. Social support influences depressive symptoms, self-care, and hospital readmissions. Shared care was used to operationalize social support. Shared care is a system of three relationship processes communication, decision making, and reciprocity, used to exchange social support. The purpose of …

Using Group Model Building To Understand Factors That Influence Childhood Obesity In An Urban Environment, David A. Nelson, Christopher J. Simenz, Sarah P. O'Connor, Yvonne Greer, Ann L. Bachrach, Tony Shields, Brett A. Fuller, Katie Horrigan, Kathleen Pritchard, Judy B. Springer, John R. Meurer

Exercise Science Faculty Research and Publications

Background: Despite increased attention, conventional views of obesity are based upon individual behaviors, and children and parents living with obesity are assumed to be the primary problem solvers. Instead of focusing exclusively on individual reduction behaviors for childhood obesity, greater focus should be placed on better understanding existing community systems and their effects on obesity. The Milwaukee Childhood Obesity Prevention Project is a community-based coalition established to develop policy and environmental change strategies to impact childhood obesity in Milwaukee, Wisconsin. The coalition conducted a Group Model Building exercise to better understand root causes of childhood obesity in its community.

Methods: …

Induced Ankylosis Of A Primary Molar For Skeletal Anchorage In The Mandible As Alternative To Mini-Implants, Matina V. Angelopoulou, Despina Koletsi, George Vadiakas, Demetrios J. Halazonetis

School of Dentistry Faculty Research and Publications

Background

Mesial protraction of mandibular posterior teeth requires increased anchorage to avoid undesired tooth movements. Orthodontic mini-implants have become a popular and successful way to increase skeletal anchorage in such cases. However, mini-implants may cause injury to adjacent teeth or anatomical structures and may lead to tissue inflammation. Induced ankylosed primary teeth have been used in the past as abutments for the protraction of the maxilla in cases of maxillary retrognathism. However, this technique has not been described in the literature for the protraction of mandibular molars. The aim of this paper is to present, through a case report, an …

Anesthesia Preoperative Clinic Referral For Elevated Hba1c Reduces Complication Rate In Diabetic Patients Undergoing Total Joint Arthroplasty, Peter J. Kallio, Jenea Nolan, Amy C. Olsen, Susan Breakwell, Richard Topp, Paul S. Pagel

College of Nursing Faculty Research and Publications

Background: Diabetes mellitus (DM) is risk factor for complications after orthopedic surgery.

Objectives: We tested the hypothesis that anesthesia preoperative clinic (APC) referral for elevated glycosylated hemoglobin (HbA1c) reduces complication rate after total joint arthroplasty (TJA).

Patients and Methods: Patients (n = 203) with and without DM were chosen from 1,237 patients undergoing TJA during 2006 - 12. Patients evaluated in the APC had surgery in 2006 - 8 regardless of HbA1c (uncontrolled). Those evaluated between in subsequent two-year intervals were referred to primary care for HbA1c ≥ 10% and ≥ 8%, respectively, to improve DM control before surgery. Complications …

“Not Being Able To Talk Was Horrid”: A Descriptive, Correlational Study Of Communication During Mechanical Ventilation, Jill L. Guttormson, Karin Lindstrom Bremmer, Rachel M. Jones

College of Nursing Faculty Research and Publications

Objectives: The purpose of this study was to describe the patient experience of communication during mechanical ventilation.

Research methodology: This descriptive study is a secondary analysis of data collected to study the relationship between sedation and the MV patients’ recall of the ICU. Interviews, conducted after extubation, included the Intensive Care Experience Questionnaire. Data were analysed with Spearman correlation coefficients (r_s) and content analysis.

Setting: Participants were recruited from a medical-surgical intensive care unit in the Midwest United States.

Results: Participants (n = 31) with a mean age of 65 ± 11.9 were on the …