Medicine and Health Sciences Commons^™

Nanomagnetic-Mediated Drug Delivery For The Treatment Of Dental Disease, Yadong Ji, Seung K. Choi, Ahmed S. Sultan, Kong Chuncai, Xiaoying Lin, Erfan Dashtimoghadam, Mary Anne Melo, Michael Weir, Huakun Xu, Lobat Tayebi, Ahihong Nie, Didier A. Depireux, Radi Masri

School of Dentistry Faculty Research and Publications

Maintaining the vitality of the dental pulp, the highly innervated and highly vascular, innermost layer of the tooth, is a critical goal of any dental procedure. Upon injury, targeting the pulp with specific therapies is challenging because it is encased in hard tissues. This project describes a method that can effectively deliver therapeutic agents to the pulp. This method relies on the use of nanoparticles that can be actively steered using magnetic forces to the pulp, traveling through naturally occurring channels in the dentin (the middle layer of the tooth). This method can reduce the inflammation of injured pulp and …

The Effect Of Partially Exposed Connective Tissue Graft On Root‐Coverage Outcomes: A Systematic Review And Meta‐Analysis, Austin Dodge, Jeffrey Garcia, Paul Luepke, Yu-Lin Lai, Moawia M. Kassab, Guo-Hao Lin

School of Dentistry Faculty Research and Publications

The aim of this systematic review was to compare the root‐coverage outcomes of using a partially exposed connective tissue graft (CTG) technique with a fully covered CTG technique for root coverage. An electronic search up to February 28^th, 2017, was performed to identify human clinical studies with data comparing outcomes of root coverage using CTG, with and without a partially exposed graft. Five clinical studies were selected for inclusion in this review. For each study, the gain of keratinized gingiva, reduction of recession depth, number of surgical sites achieving complete root coverage, percentage of root coverage, gain of …

Trends And Racial/Ethnic Disparities In Antibiotic Prescribing Practices Of Dentists In The United States, Christopher Okunseri, C. Zheng, C. N. Steinmetz, Elaye Okunseri, Aniko Szabo

School of Dentistry Faculty Research and Publications

Objective

The aim of this study was to examine trends and racial/ethnic disparities in antibiotic prescribing practices of dentists in the United States.

Methods

The US Medical Expenditure Panel Survey data for 1996‐2013 was analyzed. Information on patient sociodemographic characteristics, dental visits, receipt of dental procedures, and type of antibiotics prescribed following visits was obtained. Descriptive statistics were calculated separately for each year. Logistic regression analyses were conducted to identify associations during the period with and without adjustment for dental procedures and sociodemographic characteristics. Survey weights were incorporated to handle the sampling design.

Results

Nationally, the number of antibiotic prescribed …

Endogenous Dopamine And Endocannabinoid Signaling Mediate Cocaine-Induced Reversal Of Ampar Synaptic Potentiation In The Nucleus Accumbens Shell, Anna E. Ingebretson, Matthew C. Hearing, Ethan D. Huffington, Mark J. Thomas

Biomedical Sciences Faculty Research and Publications

Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior. Within meso-corticolimbic dopamine circuitry, repeated exposure to cocaine induces progressive alterations in AMPAR-mediated glutamatergic synaptic transmission. During a 10–14 day period of abstinence from cocaine, AMPAR signaling is potentiated at synapses on nucleus accumbens (NAc) medium spiny neurons (MSNs), promoting a state of heightened synaptic excitability. Re-exposure to cocaine during abstinence, however, rapidly reverses and depotentiates enhanced AMPAR signaling. To understand how re-exposure to cocaine alters AMPAR synaptic transmission, we investigated the roles of dopamine …

Kappa Counterconditioning Of Cocaine Cues, John R. Mantsch, Robert C. Twining

Biomedical Sciences Faculty Research and Publications

No abstract provided.

Being Invisible: Stereotype Threat In An Undergraduate Nursing Program, Amber Young-Brice, Kristina Dreifuerst, Aaron Buseh

College of Nursing Faculty Research and Publications

Background:

Nursing programs continue to be challenged to increase recruitment and retention of ethnic minority nursing students to meet the needs of a diversifying population. Ethnic minority students face a cadre of barriers, one of which is the negative implications of their own identity. This article describes a qualitative study that explored the experiences of stereotype threat among a group of ethnic minority nursing students at a large urban university.

Method:

Semistructured, one-time in-depth interviews were conducted.

Result:

Three themes emerged: A Sense of Uncertainty About Abilities, Avoidance, and Vigilance for Signs of Failure.

Conclusion:

Nursing faculty and administrators may …

Angioleiomyoma (Vascular Leiomyoma) Of The Oral Cavity, Swati Y. Rawal, Yeshwant B. Rawal

School of Dentistry Faculty Research and Publications

A 70-year-old male presented with a slow growing, dome shaped and painless mass of the hard palate. The mass was excised. Histopathological examination confirmed the diagnosis of a angioleiomyoma (vascular leiomyoma). A leiomyoma is an uncommon benign tumor of smooth muscle differentiation. True leiomyomas of the oral cavity are rare and most oral tumors are derived from the smooth muscle of walls of blood vessels. Therefore, they are called vascular leiomyomas or angioleiomyomas. Clinically, they may resemble a myriad other conditions both benign and malignant. A definitive diagnosis depends upon histopathological examination of the biopsied tissue in correlation with the …

3d-Printed Membrane For Guided Tissue Regeneration, Lobat Tayebi, Morteza Rasoulianboroujeni, Keyvan Moharamzadeh, Thafar K.D. Almela, Zhanfeng Cui, Hua Ye

School of Dentistry Faculty Research and Publications

Three-dimensional (3D) printing is currently being intensely studied for a diverse set of applications, including the development of bioengineered tissues, as well as the production of functional biomedical materials and devices for dental and orthopedic applications. The aim of this study was to develop and characterize a 3D-printed hybrid construct that can be potentially suitable for guided tissue regeneration (GTR). For this purpose, the rheologyanalyses have been performed on different bioinks and a specific solution comprising 8% gelatin, 2% elastin and 0.5% sodium hyaluronate has been selected as the most suitable composition for printing a structured membrane for GTR …

Is It Time To Reconsider Pressure Injuries As A Nurse-Sensitive Indicator?, Christine A. Schindler

College of Nursing Faculty Research and Publications

No abstract provided.

The Post–Endodontic Adhesive Interface: Theoretical Perspectives And Potential Flaws, Georgios Maroulakos, Jianing He, William W. Nagy

School of Dentistry Faculty Research and Publications

Introduction

The aim of this review was to analyze the potential of successful bonds of endodontic posts to radicular dentin as well as the limitations of the post–endodontic adhesive interface.

Methods

The MEDLINE/PubMed and Web of Science electronic databases were searched. The search was augmented by a manual search of the pertinent bibliographies.

Results

The post–endodontic adhesive interface finds application in the endodontic cohesive units. Many techniques and materials exist to improve the bond between endodontic posts and resin-based materials as well as between resin-based materials and radicular dentin. Different techniques used for the adhesion of metallic and fiber-reinforced posts …

Immunological Compatibility Status Of Placenta-Derived Stem Cells Is Mediated By Scaffold 3d Structure, Sara Azizian, Fatemeh Katami, Khashayar Modaresifar, Nariman Mosaffa, Habibollah Peirovi, Lobat Tayebi, Soheyl Bahrami, Heinz Redl, Hassan Niknejad

School of Dentistry Faculty Research and Publications

Placenta-derived amniotic epithelial cells (AECs), a great cell source for tissue engineering and stem cell therapy, are immunologically inert in their native state; however, immunological changes in these cells after culture and differentiation have challenged their applications. The aim of this study was to investigate the effect of 2D and 3D scaffolds on human lymphocyte antigens (HLA) expression by AECs. The effect of different preparation parameters including pre-freezing time and temperature was evaluated on 3D chitosan–gelatine scaffolds properties. Evaluation of MHC class I, HLA-DR and HLA-G expression in AECs after 7 d culture on 2D bed and 3D scaffold of …

Mediating Effects Of Positive Thinking And Social Support On Suicide Resilience, Denise M. Matel-Anderson, Abir K. Bekhet, Mauricio Garnier-Villarreal

College of Nursing Faculty Research and Publications

Suicide has been the second leading cause of death for 18- to 24-year-olds in the United States since 2011. The stress experienced by undergraduate college students has the potential to increase one’s risk for suicide. Resilience theory was used as a theoretical framework to examine the interplay between risk and protective factors. A cross-sectional and correlational design was used to assess the mediating effects of positive thinking and/or social support on suicide resilience in 131 college students 18 to 24 years old who completed an online survey. The study found an indirect effect of self-esteem on suicide resilience through positive …

Collagenous Matrix Supported By A 3d-Printed Scaffold For Osteogenic Differentiation Of Dental Pulp Cells, Farahnaz Fahimipour, Erfan Dashtimoghadam, Morteza Rasoulianboroujeni, Mostafa Yazdimamaghani, Kimia Khoshroo, Mohammadreza Tahriri, Amir Yadegari, Jose Gonzalez, Daryoosh Vashaee, Douglas C. Lobner, Tahereh S. Jafarzadeh Kashi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Objective

A systematic characterization of hybrid scaffolds, fabricated based on combinatorial additive manufacturing technique and freeze-drying method, is presented as a new platform for osteoblastic differentiation of dental pulp cells (DPCs).

Methods

The scaffolds were consisted of a collagenous matrix embedded in a 3D-printed beta-tricalcium phosphate (β-TCP) as the mineral phase. The developed construct design was intended to achieve mechanical robustness owing to 3D-printed β-TCP scaffold, and biologically active 3D cell culture matrix pertaining to the Collagen extracellular matrix. The β-TCP precursor formulations were investigated for their flow-ability at various temperatures, which optimized for fabrication of 3D printed scaffolds with …

A Randomized, Controlled Clinical Study To Assess The Effect Of Anodal And Cathodal Electrical Stimulation On Periwound Skin Blood Flow And Pressure Ulcer Size Reduction In Persons With Neurological Injuries, Anna Polak, Cezary Kucio, Luther C. Kloth, Malgorzata Paczula, Ewa Hordynska, Tomasz Ickowicz, Edward Blaszczak, Ewa Kucio, Krystian Oleszczyk, Krzysztof Ficek, Andrzej Franek

Physical Therapy Faculty Research and Publications

The use of electrical stimulation (ES) should be considered for treating nonhealing pressure ulcers (PUs), but optimal ES wound treatment protocols have yet to be established. A randomized, controlled, double-blind clinical study was conducted to evaluate the effects of cathodal and anodal high-voltage monophasic pulsed current (HVMPC) on periwound skin blood flow (PSBF) and size reduction of Stage 2 to Stage 4 PUs of at least 4 weeks’ duration.Persons >18 years of age, hospitalized with neurological injuries, at high risk for PU development (Norton scale <14 >points; Waterlow scale >15 points), and with at least 1 Stage 2 to Stage 4 …

Psychometric Properties Of The Positive Thinking Skills Scale Among College Students, Denise M. Matel-Anderson, Abir K. Bekhet

College of Nursing Faculty Research and Publications

Suicide continues to be in the top leading causes of death among college students. Positive thinking has been linked to increasing health outcomes and decreasing the effects of stress. The psychometric properties of the 8-item Positive Thinking Skills Scale (PTSS) has not been tested in American college students. The study used resilience as the theoretical framework. In 131 students, internal consistency and construct validity was supported. The Cronbach's alpha of 0.86 and significant correlation with measures of suicide resilience, perceived social support, and self-esteem demonstrated good reliability and validity. The findings of the study provide directions for future suicide prevention …

Does An Intervention Designed To Improve Self-Management, Social Support And Awareness Of Palliative-Care Address Needs Of Persons With Heart Failure, Family Caregivers And Clinicians?, Margaret Sebern, Nasir Sulemanjee, Mauricio Garnier-Villarreal, Mark J. Sebern, Carol J. Whitlatch

College of Nursing Faculty Research and Publications

Aims and Objectives

To conduct a formative evaluation of the iPad‐Enhanced Shared Care Intervention for Partners (iSCIP) among persons with heart failure (HF), family caregivers and clinicians. Together, persons with HF and family caregivers are referred to as partners.

Background

There is growing awareness of the caregiver's contributions to HF self‐management, social support and reciprocal benefits of interventions that involve both partners. The iSCIP engages both partners in a six‐session psychosocial intervention to address three preventable causes of poor outcomes in a HF population: poor self‐management skills, inadequate social support and underutilisation of palliative care. An iPad app is used …

Current Medical Research Winter/Spring 2017, Richard Fehring, Kathleen Raviele

College of Nursing Faculty Research and Publications

No abstract provided.

Resilience From The Perspectives Of Caregivers Of Persons With Dementia, Abir K. Bekhet, Jennifer Sjostedt Avery

College of Nursing Faculty Research and Publications

No abstract provided.

Outreach: Change The World, Change Yourself, Geoffrey A. Thompson, Edward J. Plekavich, Izchak Barzilay

School of Dentistry Faculty Research and Publications

No abstract provided.

Giant Pilomatrix Carcinoma Of The Face, Sapna Lohiya, Yeshwant B. Rawal, Jasjit K. Dillon

School of Dentistry Faculty Research and Publications

This case report describes an unusually large facial pilomatrix carcinoma (PC) in a 60-year-old man. This PC had been growing slowly for 11 months and had recently ulcerated. It measured 9 cm × 7 cm × 5 cm. Initial punch biopsy findings were inconclusive. The tumor was excised in total with 5-mm margins in a supra-superficial musculoaponeurotic system plane. The defect was reconstructed with a cervicofacial bilobed rotational advancement flap. Histopathologic findings confirmed the diagnosis of PC. There was no lymph node spread or distant metastasis. The patient recovered with a good esthetic result. This case represents one of the …

Survival Rates Of Teeth With Primary Endodontic Treatment After Core/Post And Crown Placement, Kandace Yee, Bhagavatula Pradeep, Sheila E. Stover, Fredrick Eichmiller, Lance Hashimoto, Scott Macdonald, Gordon L. Barkley Iii

School of Dentistry Faculty Research and Publications

Introduction

The objective of this study was to determine the effect of delayed placement of the core/post and crown on the outcomes of nonsurgical root canal therapy (NSRCT).

Methods

According to the Delta Dental of Wisconsin claims database, 160,040 NSRCTs were completed with a core/post and a crown placed before the end of the continuous coverage period or occurrence of an untoward event. Untoward events were defined as a retreatment, apicoectomy, or extraction as defined by the Code on Dental Procedures and Nomenclature. Statistical analysis was performed by using a multivariable Cox proportional hazards model.

Results

The survival rate from …

A Method Of Locating The Abutment Screw Access Channel With Cone-Beam Computed Tomography And A 3d-Printed Drilling Guide, Waleed Nasir Asiri, Agnieszka Domagala, Seok-Hwan Cho, Geoffrey A. Thompson

School of Dentistry Faculty Research and Publications

In managing loose abutment screws, locating precisely the position of the screw access channel is difficult. This technique describes the use of cone-beam computed tomography (CBCT) and surgical guide planning software to locate the screw access channel with the intention of retrieving a loosened cement-retained implant-supported prosthesis. The method minimizes damage to the abutment crown assembly.

Orthognathic Surgical Outcomes In Patients With And Without Craniofacial Anomalies, Zohra Metalwala, Christopher Okunseri, Steven Fletcher, Veerasathpurush Allareddy

School of Dentistry Faculty Research and Publications

Purpose

The objective of this study is to examine hospitalization outcomes after orthognathic surgery. This study tests the hypothesis that patients with craniofacial anomalies have higher billed hospital charges, longer lengths of stay, and increased odds of development of infectious complications when compared with patients without craniofacial anomalies.

Materials and Methods

The Nationwide Inpatient Sample for the years 2012 and 2013 was used. All patients who underwent an orthognathic surgical procedure were selected. The primary independent variable of interest was presence of a congenital cleft and/or craniofacial anomaly. The outcome variables were the occurrence of complications, billed hospital charges, and …

Klf6 And Stat3 Co-Occupy Regulatory Dna And Functionally Synergize To Promote Axon Growth In Cns Neurons, Zimei Wang, Vatsal Mehra, Matthew T. Simpson, Brian Maunze, Dan C. Eastwood, Lyndsey Holan, Murray G. Blackmore, Ishwariya Venkatesh

Biomedical Sciences Faculty Research and Publications

The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear. Here we show that forced expression of KLF6 promotes axon regeneration by corticospinal tract neurons in the injured spinal cord. RNA sequencing identified 454 genes whose expression changed upon forced KLF6 expression in vitro, including sub-networks that were highly enriched for functions relevant to axon extension including cytoskeleton remodeling, lipid synthesis, and bioenergetics. In addition, promoter analysis predicted a functional interaction …

Achieving Pregnancy Using Primary Care Interventions To Identify The Fertile Window, Thomas Bouchard, Richard Fehring, Mary Schneider

College of Nursing Faculty Research and Publications

Objective: To determine the effectiveness of achieving pregnancy with focused intercourse in the fertile window identified using natural fertility indicators. Methods: 24-cycle prospective effectiveness study. Setting: A North American web-based fertility monitoring service. Participants: 256 North American women aged 20–43 (mean age 29.2 years) seeking to achieve pregnancy. Intervention: Participants identified their fertile window with either electronic hormonal fertility monitoring or cervical mucus monitoring, or both, and recorded their observations on an online fertility tracking system. Main outcome measures: Pregnancies were validated by nurses with an online self-assessed pregnancy evaluation form. Survival analysis was used to determine pregnancy rates. Results: …

Surprised By Benefit In Pediatric Palliative Care Research, Meaghann S. Weaver, Cynthia J. Bell, Jessica L. Diver, Shana Jacobs, Maureen E. Lyon, Kim Mooney-Doyle, Amy Rose Newman, Julia Slutsman, Pamela S. Hinds

College of Nursing Faculty Research and Publications

No abstract provided.

What Does The Fos Say? Using Fos-Based Approaches To Understand The Contribution Of Stress To Substance Use Disorders, Jayme R. Mcreynolds, John P. Christianson, Jordan M. Blacktop, John Mantsch

Biomedical Sciences Faculty Research and Publications

Despite extensive research efforts, drug addiction persists as a largely unmet medical need. Perhaps the biggest challenge for treating addiction is the high rate of recidivism. While many factors can promote relapse in abstinent drug users, the contribution of stress is particularly problematic, as stress is uncontrollable and pervasive in the lives of those struggling with addiction. Thus, understanding the neurocircuitry that underlies the influence of stress on drug seeking is critical for guiding treatment. Preclinical research aimed at defining this neurocircuitry has, in part, relied upon the use of experimental approaches that allow visualization of cellular and circuit activity …

17Β-Estradiol Potentiates The Reinstatement Of Cocaine Seeking In Female Rats: Role Of The Prelimbic Prefrontal Cortex And Cannabinoid Type-1 Receptors, Elizabeth M. Doncheck, Luke A. Urbanik, Margot C. Debaker, Laura M. Barron, Gage T. Liddiard, Jennifer J. Tuscher, Karyn M. Frick, Cecilia J. Hillard, John Mantsch

Biomedical Sciences Faculty Research and Publications

Clinical observations imply that female cocaine addicts experience enhanced relapse vulnerability compared with males, an effect tied to elevated estrogen phases of the ovarian hormone cycle. Although estrogens can enhance drug-seeking behavior, they do not directly induce reinstatement on their own. To model this phenomenon, we tested whether an estrogen could augment drug-seeking behavior in response to an ordinarily subthreshold reinstatement trigger. Following cocaine self-administration and extinction, female rats were ovariectomized to isolate estrogen effects on reinstatement. Although neither peak proestrus levels of the primary estrogen 17β-estradiol (E2; 10 μg/kg, i.p., 1-h pretreatment) nor a subthreshold cocaine dose …

Transport Of Bmaa Into Neurons And Astrocytes By System XC-, Rebecca Albano, Doug Lobner

Biomedical Sciences Faculty Research and Publications

The study of the mechanism of β-N-methylamino-l-alanine (BMAA) neurotoxicity originally focused on its effects at the N-methyl-d-aspartate (NMDA) receptor. In recent years, it has become clear that its mechanism of action is more complicated. First, there are certain cell types, such as motor neurons and cholinergic neurons, where the dominate mechanism of toxicity is through action at AMPA receptors. Second, even in cortical neurons where the primary mechanism of toxicity appears to be activation of NMDA receptors, there are other mechanisms involved. We found that along with NMDA receptors, activation of mGLuR5 receptors and effects on the …

The Opiod Epidemic: Clinical Dental Update, Matthew Hearing

Biomedical Sciences Faculty Research and Publications

No abstract provided.