Medicine and Health Sciences Commons^™

Psychostimulant Misuse Among American Indian, Alaskan Native, Or Native Hawaiian College Students In The U.S. From 2015 To 2019, Fares Qeadan, Sydney Ross, William A. Barbeau, Erin F. Madden, Kamilla L. Venner, Kevin English

Parkinson School of Health Sciences and Public Health

Introduction: This study examines factors associated with psychostimulant misuse, including polysubstance use and social factors, among the understudied American Indian/Alaska Native/Native Hawaiian (AI/AN/NH) college student population.

Methods: Data were from the 2015 to 2019 American College Health Association-National College Health Assessment IIc (ACHA-NCHA IIc) survey. Multivariable logistic regression models and odds ratios were used to estimate associations between psychostimulant misuse and potential risk and protective factors among AI/AN/NH college students, including licit and illicit substance use, social support, relationship factors, exposure to violence or abuse, mental health symptoms, drug and alcohol education, and sample demographics.

Results: Opioid misuse among AI/AN/NH …

Intersectionality Of Demographic Characteristics In Self-Reported Anorexia Nervosa, Bulimia Nervosa, And Probable Eating Disorders Among College Students, Jamie Egbert, Amy Luke, Fares Qeadan

Parkinson School of Health Sciences and Public Health

Objective:

To investigate associations between identity intersectionality, with a primary focus on minority identity, and probable eating disorders (EDs) within the US college student population.

Method:

Data consisting of n=414,299 college students' responses to the American College Health Association's National College Health Assessment between fall 2015and spring 2019 were utilized for this study. Overall and stratified adjusted odds ratios (aORs) were used to assess the association between different facets of identity(i.e., race/ethnicity, gender identity, and sexual orientation) and probable EDs.

Results:

Among all, in our analytic sample, 7.15% reported a probable ED. Interactions between all three identity variables were significant, …

Tak1 And Tbk1 Are Differentially Required By Gmp- And Lmpp-Like Leukemia Stem Cells, Austin P. Runde, Joseph Michael Cannova, Ryan Mack, Kanak Joshi, Mark Sellin, Allan Youmaran, Mattias Lenz, Rohit Thalla, Wei Wei, Peter Breslin S.J., Jiwang Zhang

School of Medicine

Acute myeloid leukemia (AML) encompasses a diverse group of cancers that originate in the blood-forming tissues of the bone marrow. Aside from the M3 subtype (PML-RARA⁺), AML carries a 5-year survival rate of 28% for patients 20+ years of age. AML is the most common cancer of the hematopoietic system and is slightly more common in biological males; the average age at diagnosis is 68 years. Standard frontline treatment for AML is a 2-phase regimen of intensive chemotherapy (CTx) employing daunorubicin and cytarabine. Despite 60-70% of patients achieving complete remission (CR), at least half of CR-achieving patients …

Dispensing With Reductionism And Dualism: Biological Anthropological Perspectives Towards Understanding Disease, Epidemics, And Pandemics, Anne Grauer

Anthropology: Faculty Publications and Other Works

At no time in recent history has the topic of disease, epidemics and pandemics been more at the forefront of public conversation than it is now. Previously, the threat of epidemics such as Ebola, the 1918 influenza epidemic, and the plague, were commonly framed as “back then” or “over there.” Perhaps COVID ended the public's delusion. For biological anthropologists, however, the perspective has differed appreciably. Pandemics and epidemics are viewed as integral and repeated aspects of human existence, and the kindling to start an outbreak of gargantuan proportion has been delicately stacked for centuries (if not millennia). If the public …

Academic Motivation Decreases Across Adolescence For Youth With And Without Attention-Deficit/Hyperactivity Disorder: Effects Of Motivation On Academic Success, Zoe Smith, Marcus Flax, Stephen P. Becker, Joshua Langberg

Psychology: Faculty Publications and Other Works

This longitudinal study examined growth trajectories of academic motivation in youth with and without attention-deficit/hyperactivity disorder (ADHD) across the important developmental transition from middle school to high school, and associations with academic success. Consistent with self-determination theory (SDT) of motivation, trajectories of amotivation, extrinsic motivation, and intrinsic motivation were modeled.

Applying Customer Discovery Method To A Chronic Disease Self-Management Mobile App: Qualitative Study, Nallely Mora, Zoe Arvanitakis, Merly Thomas, Holly Kramer, Elaine H. Morrato, Talar W. Markossian

Parkinson School of Health Sciences and Public Health

Background: A significant health challenge is evident in the United States, with 6 in 10 adults having a chronic disease and 4 in 10 adults having 2 or more. Chronic disease self-management aims to prevent or delay disease progression and disability and reduce mortality risk. The evidence to support the use of information technology tools, including mobile apps, web-based portals, and web-based educational interventions, that support disease self-management and improve clinical outcomes is growing. Customer discovery and value proposition design methodology is a form of stakeholder engagement and is based on marketing and lean start-up business methods. As applied in …

Effects Of Noise Electrical Stimulation On Proprioception, Force Control, And Corticomuscular Functional Connectivity, Li-Wei Chou, Shiang-Lin Hou, Hui-Min Lee, Felipe Fregni, Alice Yen, Vincent Chiun-Fan Chen, Shun-Hwa Wei, Chung-Lan Kao

Engineering Science Faculty Publications

Sensory afferent inputs play an important role in neuromuscular functions. Subsensory level noise electrical stimulation enhances the sensitivity of peripheral sensory system and improves lower extremity motor function. The current study aimed to investigate the immediate effects of noise electrical stimulation on proprioceptive senses and grip force control, and whether there are associated neural activities in the central nervous system. Fourteen healthy adults participated in 2 experiments on 2 different days. In day 1, participants performed grip force and joint proprioceptive tasks with and without (sham) noise electrical stimulation. In day 2, participants performed grip force steady hold task before …

Patient Guide To: Stevens-Johnson Syndrome (Sjs) And Toxic Epidermal Necrolysis (Ten), Djoni Elkady, Eden Lake Md

School of Medicine

No abstract provided.

Cellular Mechanisms Underlying State-Dependent Neural Inhibition With Magnetic Stimulation, Hui Ye, Vincent Chiun-Fan Chen, Jenna Hendee

Engineering Science Faculty Publications

Novel stimulation protocols for neuromodulation with magnetic fields are explored in clinical and laboratory settings. Recent evidence suggests that the activation state of the nervous system plays a significant role in the outcome of magnetic stimulation, but the underlying cellular and molecular mechanisms of state-dependency have not been completely investigated. We recently reported that high frequency magnetic stimulation could inhibit neural activity when the neuron was in a low active state. In this paper, we investigate state-dependent neural modulation by applying a magnetic field to single neurons, using the novel micro-coil technology. High frequency magnetic stimulation suppressed single neuron activity …

Development Of An Analytical Method For Determination Of Lead And Cadmium In Biological Materials By Gfaas Using Escherichia Coli As Model Substance, Michelle Catherine Gende, Martina Schmeling

Chemistry: Faculty Publications and Other Works

In this work, an analytical method was developed for the determination of lead and cadmium in biological samples using graphite furnace atomic absorption spectrometry. Escherichia coli (E. coli) was chosen as model substance for this purpose as it is readily available in most laboratories and can be quickly and easily prepared with a high turnaround rate. Four different sample preparation methods were initially evaluated with respect to percent recovery, limit of detection, and limit of quantification, and the most promising one was developed further. The final process involving microwave assisted digestion of the sample with nitric acid …

Vitamin D Supplementation For The Treatment Of Depressive Symptoms In Women With Type 2 Diabetes: A Randomized Clinical Trial, Sue Penckofer Phd, Monique Ridosh, William Howard Adams, Meghan Grzesiak, Jennifer Woo, Mary Byrn, Joanne Kouba Phd, Rdn, Ldn, Patricia M. Sheean, Colleen Kordish, Ramon Durazo-Arvizu, Diane Wallis, Mary Ann Emanuele, Angelos Halaris

Nursing: School of Nursing Faculty Publications and Other Works

Aim. To determine the efficacy and safety of vitamin D₃ supplementation in reducing depressive symptoms in women with type 2 diabetes (T2D), depression, and low vitamin D. Methods. In this double-blind randomized active comparator-controlled trial, women with significant depressive symptoms as assessed by the Center for Epidemiologic Studies Depression (CES-D) scale received weekly oral vitamin D₃ supplementation (50,000 IU) or an active comparator (5,000 IU) for 6 months. Assessments of vitamin D, 25-hydroxyvitamin D [25 (OH) D], and depression were measured at baseline, 3 months, and 6 months. Results. A total of 129 women were …

Trajectories Of Self-Management And Independence In Youth With Spina Bifida: Demographic Predictors Of Growth, Monique M. Ridosh, William Adams, Fabiola Magana, Kathleen J. Sawin, Grayson N. Holmbeck

Nursing: School of Nursing Faculty Publications and Other Works

Aim: The purpose of this study was to examine the trajectories of condition and independent living self-management in youth with spina bifida (SB). MethodsA diverse sample of adolescents and young adults (AYAs) with SB completed the Adolescent/Young Adult Self-Management and Independence Scale (AMIS-II) across four time points. Parents reported on demographic characteristics including age, sex, race/ethnicity, and family income. Growth in self-management and its subscales (condition and independent living) were estimated using linear mixed-effect models as a function of respondents' demographics.ResultsThis study included 99 respondents age 18 to 27 years old. About half were female (52.5%) and White (52.5%); 15.2% …

Preexisting Psychological Illness And Its Association With Mortality In Lung Cancer Patients With Access To Support Resources, Allison E. Wright, Elycee Sheehan, Fares Qeadan, Lily Stalter, Ali Imran Saeed

Parkinson School of Health Sciences and Public Health

Abstract Introduction: Diagnosis of lung cancer often results in tremendous stress for most patients, especially in patients with underlying psychological illness. Psy- chosocial support (consultation with psychologist, psychotherapist, or social worker) referral is considered standard for quality cancer care; however, which patients utilize these resources and how these resources affect patient out- comes remain unclear. Objectives: We aimed to identify which newly diagnosed lung cancer patients accessed available psychosocial resources and assessed how utilization of these resources correlated with treatment and survival outcomes. Methods: Data were collected from National Cancer Institute-designated can- cer center at the University of New Mexico. …

A Flexible Mixed-Data Model Applied To Claims Data For Post-Market Surveillance Of Prescription Drug Safety Behavior, Harris Butler, John D. Rice, Nichole E. Carlson, Elaine H. Morrato

Parkinson School of Health Sciences and Public Health

We develop a new modeling framework for jointly modeling first prescription times and the presence of risk-mitigating behavior for prescription drugs using real-world data. We are interested in active surveillance of clinical quality improvement programs, especially for drugs which enter the market under an FDA-mandated Risk Evaluation and Mitigation Strategy (REMS). Our modeling framework attempts to jointly model two important aspects of prescribing, the time between a drug's initial marketing and a patient's first prescription of that drug, and the presence of risk-mitigating behavior at the first prescription. First prescription times can be flexibly modeled as a mixture of component …

Bisindolylmaleimide Ix: A Novel Anti-Sars-Cov2 Agent Targeting Viral Main Protease 3clpro Demonstrated By Virtual Screening Pipeline And In-Vitro Validation Assays, Yash Gupta, Dawid Maciorowski, Samantha E. Zak, Krysten A. Jones, Rahul S. Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Andrew S. Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P. Becker, Bryan C. Dickinson, John M. Dye, Prakasha Kempaiah

Chemistry: Faculty Publications and Other Works

SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with essential functions within its proteome. Here, we focused on repurposing approved and investigational drugs/compounds. We targeted seven proteins with enzymatic activities known to be essential at different stages of the viral cycle including PLpro, 3CLpro, RdRP, Helicase, ExoN, NendoU, and 2′-O-MT. For virtual screening, energy minimization of a crystal structure of the modeled protein was carried out using the Protein Preparation Wizard (Schrodinger LLC 2020-1). Following active site selection based on data mining and COACH predictions, we performed a high-throughput virtual screen of drugs and investigational molecules (n = …

Managing Vibration Training Safety By Using Knee Flexion Angle And Rating Perceived Exertion, Long-Ren Chuang, Wen-Wen Yang, Po-Ling Chang, Vincent Chiun-Fan Chen, Chiang Liu, Tzyy-Yuang Shiang

Engineering Science Faculty Publications

Whole-body vibration (WBV) is commonly applied in exercise and rehabilitation and its safety issues have been a major concern. Vibration measured using accelerometers can be used to further analyze the vibration transmissibility. Optimal bending angles and rating of perceived exertion (RPE) evaluations have not been sufficiently explored to mitigate the adverse effect. Therefore, the aims of this study were to investigate the effect of various knee flexion angles on the transmissibility to the head and knee, the RPE during WBV exposure, and the link between the transmissibility to the head and the RPE. Sixteen participants randomly performed static squats with …

Axonal Blockage With Microscopic Magnetic Stimulation, Hui Ye

Biology: Faculty Publications and Other Works

Numerous neurological dysfunctions are characterized by undesirable nerve activity. By providing reversible nerve blockage, electric stimulation with an implanted electrode holds promise in the treatment of these conditions. However, there are several limitations to its application, including poor bio-compatibility and decreased efficacy during chronic implantation. A magnetic coil of miniature size can mitigate some of these problems, by coating it with biocompatible material for chronic implantation. However, it is unknown if miniature coils could be effective in axonal blockage and, if so, what the underlying mechanisms are. Here we demonstrate that a submillimeter magnetic coil can reversibly block action potentials …

Underfeeding Patients With Critical Illness: Making Sense Of Recent Data, Jacklyn C. Hook, Patricia M. Sheean

Parkinson School of Health Sciences and Public Health

Nutrition support is recognized as an important component of care for patients with critical illness. Providing energy and protein at estimated requirements is thought to prevent or decrease the likelihood of disease-related malnutrition. However, short-term calorie restriction may be advantageous in this setting. Using PubMed, we conducted a search for studies of “permissive underfeeding” or “hypocaloric feeding” for patients with critical illness to evaluate relevant outcomes. Of the initial 137 studies, 32 papers were evaluated, and 16 papers met all eligibility criteria. The results support a benefit or neutral impact on nutrition support-related complications, yet conflicting findings on mortality and …

Catholicism In The Neonatal Context: Belief, Practice, Challenge, Hope, M. Therese Lysaught Phd

Institute of Pastoral Studies: Faculty Publications and Other Works

Roman Catholics comprise the largest single denomination in the United States and are the nation’s largest group of not-for-profit healthcare providers. Yet, there is little or no available literature to assist neonatal caregivers in understanding how religious beliefs and values might influence parents’ responses to the challenges posed by their newborn’s care. Equally, there is little or no available literature on the academic or pastoral side addressing questions of neonatal medicine from a theological perspective. This chapter addresses how Roman Catholic teachings might affect the ways in which parents and caregivers make treatment decisions. It examines the neonatal context in …

A Flavor Perception Game Designed To Introduce Basic Chemical Sensation Of Taste Modalities To Undergraduate Nursing And Exercise Sciences Students, Angela L. Mahaffey

Nursing: School of Nursing Faculty Publications and Other Works

The Flavor Perception Game was designed with the goals of developing an interactive and hands-on activity, providing a platform to review chemical senses of the five tastes, promoting student investment in the course material, and providing a basis for discussion on chemical senses of the five tastes. Knowledge of taste sensation is useful for nursing and exercise sciences students, as human physiology is integral to both baccalaureate curricula. The game is inexpensive, easy to incorporate into a 50-minute lecture period, and free of chocolate allergens. Student participants (N=34) tasted three candies and completed a voluntary anonymous poll regarding their detection …

Spiritual Care In Nursing Practice In Veteran Healthcare, Elizabeth Burkhart, Anna Bretschneider, Sharon Gerc, Mary E. Desmond

Nursing: School of Nursing Faculty Publications and Other Works

Spiritual care is important in nursing practice, and spiritual well-being and spiritual care are associated with better health. Military veterans, a unique patient population, want spiritual care to cope with chronic conditions. It is unclear whether spiritual care is provided in veteran health care in the United States. This study used a qualitative descriptive method, guided by the Spiritual Care in Nursing Practice (SCNiP) theory, to describe spiritual care in nursing practice and facilitators/barriers in veteran health care. Individual interviews were conducted with 39 registered nurses (RNs) at a U.S. veteran health system. Findings were consistent with the SCNiP theory …

Body Composition, Serum Biomarkers Of Inflammation And Quality Of Life In Clinically Stable Women With Estrogen Receptor Positive Metastatic Breast Cancer, Patricia M. Sheean, Sandra Gomez-Perez, Cara Joyce, Vasilios Vasilopoulos, Mary Beth Bartolotta, Patricia Robinson, Shelly Lo, Laurie Lomasney

Parkinson School of Health Sciences and Public Health

Limited data exist regarding body composition and associated patient-reported outcomes for women with metastatic BC. Demographic, clinical, blood, and questionnaire data were collected to quantify body composition and explore associations with symptoms, inflammation, and quality of life (QOL) in 41 women with ER + metastatic BC. Diagnostic/surveillance computed tomography (CT) images including the third lumbar region (L3) were obtained to evaluate skeletal muscle (SM) quantity and quality, and abdominal adipose tissue. Frequencies, medians and interquartile ranges are presented, stratified by sarcopenia and obesity (Body mass index (BMI) ≥ 30.0 kg/m2). Overall, 34% (n = 14/41), 49% (n = …

Nutrition Risk Among An Ethnically Diverse Sample Of Community-Dwelling Older Adults, Patricia M. Sheean, Isabel C. Farrar, Suela Sulo, Jamie Partridge, Linda Schiffer, Marian Fitzgibbon

Parkinson School of Health Sciences and Public Health

Objective

To assess the prevalence of nutritional risk among an ethnically diverse group of urban community-dwelling older adults and to explore if risk varied by race/ethnicity. Design

Demographic characteristics, Katz’s activities of daily living and health-care resource utilization were ascertained cross-sectionally via telephone surveys with trained interviewers. Nutrition risk and nutrition symptomology were assessed via the abridged Patient Generated Subjective Global Assessment (abPG-SGA); scores of ≥6 points delineated ‘high’ nutrition risk. Descriptive statistics and logistic regression analyses were conducted. Setting

Urban. Participants

White, Black or Hispanic community-dwelling adults, ≥55 years of age, fluent in English or Spanish, residing in the …

Developing A Business Case For The Care Coordination And Transition Management Model: Needs, Methods, And Measures, Sheila Haas, Beth A. Swan, Rachel Start, Regina Conway-Phillips, Laura A. De La Pena, Diane Storer Brown

Nursing: School of Nursing Faculty Publications and Other Works

In this descriptive qualitative study, nurse and healthcare leaders' experiences, perceptions of care coordination and transition management (CCTM®), and insights as to how to foster adoption of the CCTM RN role in nursing education, practice across the continuum, and policy were explored. Twenty-five barriers to recognition and adoption of CCTM RN practice across the continuum were identified and categorized. Implications of these findings, recommendations for adoption of CCTM RN practice across the care continuum, and strategies for reimbursement policies are discussed.

Optimizing Strategies For Care Coordination And Transition Management: Recommendations For Nursing Education, Beth Ann Swan, Regina Conway-Phillips, Sheila Haas, Laura A. De La Pena

Nursing: School of Nursing Faculty Publications and Other Works

The purpose of this descriptive qualitative study was to explore nurse and healthcare leaders' experiences and perceptions of care coordination and transition management (CCTM®). Four barriers emerged that added insight into the lack of adopting and integrating CCTM knowledge, skills, and attitudes in nursing education in the following categories: curriculum redesign, silos of care settings and care providers, knowledge gap, and faculty development/resistance. Recommendations and implications for education, for both nursing students and practicing nurses, are described.

Equally Strange Fruit: Catholic Health Care And The Appropriation Of Residential Segregation, Cory D. Mitchell, M. Therese Lysaught

Institute of Pastoral Studies: Faculty Publications and Other Works

FROM THE EARLIEST BEGINNINGS OF CHRISTIAN history and from the moment the Ursuline Sisters opened the first Catholic hospital in the United States in 1728, charity toward the poor and marginalized has been the chief identifying characteristic of Catholic health care.3 Again and again, small groups of in-trepid nuns sought out the poorest communities, set up hospitals, in-novated on reimbursement methods, raised donations, lived in solidarity with and dedicated their lives to caring for the health needs of the poor, needs often exacerbated by extraordinarily difficult living conditions.4

Which Activities Count? Using Experimental Data To Understand Conceptualizations Of Physical Activity, Rachel Cusatis, Dana Garbarski

Sociology: Faculty Publications and Other Works

US health surveys consistently report that men and those with higher socioeconomic status (SES) engage in more physical activity than women and lower SES counterparts, using questions that ask about physical activity during leisure time. However, social characteristics such as gender and SES shape understandings of and access to leisure-based physical activity as well as other domains where healthy activity is available – namely house work, care work, and paid work. Thus, the physical activity of US adults may look different when what counts as physical activity expands beyond leisure activity.

The current study uses Amazon’s Mechanical Turk platform …

Nutrition Risk Among An Ethnically Diverse Sample Of Community-Dwelling Older Adults, Patricia M. Sheean, Isabel C. Farrar, Suela Sulo, Jamie Partridge, Linda Schiffer, Marian Fitzgibbon

Nursing: School of Nursing Faculty Publications and Other Works

Objective

To assess the prevalence of nutritional risk among an ethnically diverse group of urban community-dwelling older adults and to explore if risk varied by race/ethnicity.

Design

Demographic characteristics, Katz’s activities of daily living and health-care resource utilization were ascertained cross-sectionally via telephone surveys with trained interviewers. Nutrition risk and nutrition symptomology were assessed via the abridged Patient Generated Subjective Global Assessment (abPG-SGA); scores of ≥6 points delineated ‘high’ nutrition risk. Descriptive statistics and logistic regression analyses were conducted.

Setting

Urban.

Participants

White, Black or Hispanic community-dwelling adults, ≥55 years of age, fluent in English or Spanish, residing in the …

Validation Of The Registered Nurse Assessment Of Readiness For Hospital Discharge Scale, Kathleen L. Bobay, Marianne E. Weiss, Debra Oswald, Olga Yakusheva

Nursing: School of Nursing Faculty Publications and Other Works

Background Statistical models for predicting readmissions have been published for high-risk patient populations but typically focus on patient characteristics; nurse judgment is rarely considered in a formalized way to supplement prediction models.

Objectives The purpose of this study was to determine psychometric properties of long and short forms of the Registered Nurse Readiness for Hospital Discharge Scale (RN-RHDS), including reliability, factor structure, and predictive validity.

Methods Data were aggregated from two studies conducted at four hospitals in the Midwestern United States. The RN-RHDS was completed within 4 hours before hospital discharge by the discharging nurse. Data on readmissions and emergency …

Effects Of 8-Week Sensory Electrical Stimulation Combined With Motor Training On Eeg-Emg Coherence And Motor Function In Individuals With Stroke, Li-Ling Hope Pan, Wen-Wen Yang, Chung-Lan Kao, Mei-Wun Tsai, Shun-Hwa Wei, Felipe Fregni, Vincent Chiun-Fan Chen, Li-Wei Chou

Engineering Science Faculty Publications

The peripheral sensory system is critical to regulating motor plasticity and motor recovery. Peripheral electrical stimulation (ES) can generate constant and adequate sensory input to influence the excitability of the motor cortex. The aim of this proof of concept study was to assess whether ES prior to each hand function training session for eight weeks can better improve neuromuscular control and hand function in chronic stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES). We recruited twelve subjects and randomly assigned them into ES and control groups. Both groups received 20-minute hand function training twice …