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Full-Text Articles in Medicine and Health Sciences

Cellular Mechanisms Underlying State-Dependent Neural Inhibition With Magnetic Stimulation, Hui Ye, Vincent Chiun-Fan Chen, Jenna Hendee Jul 2022

Cellular Mechanisms Underlying State-Dependent Neural Inhibition With Magnetic Stimulation, Hui Ye, Vincent Chiun-Fan Chen, Jenna Hendee

Engineering Science Faculty Publications

Novel stimulation protocols for neuromodulation with magnetic fields are explored in clinical and laboratory settings. Recent evidence suggests that the activation state of the nervous system plays a significant role in the outcome of magnetic stimulation, but the underlying cellular and molecular mechanisms of state-dependency have not been completely investigated. We recently reported that high frequency magnetic stimulation could inhibit neural activity when the neuron was in a low active state. In this paper, we investigate state-dependent neural modulation by applying a magnetic field to single neurons, using the novel micro-coil technology. High frequency magnetic stimulation suppressed single neuron activity …


Development Of An Analytical Method For Determination Of Lead And Cadmium In Biological Materials By Gfaas Using Escherichia Coli As Model Substance, Michelle Catherine Gende, Martina Schmeling May 2022

Development Of An Analytical Method For Determination Of Lead And Cadmium In Biological Materials By Gfaas Using Escherichia Coli As Model Substance, Michelle Catherine Gende, Martina Schmeling

Chemistry: Faculty Publications and Other Works

In this work, an analytical method was developed for the determination of lead and cadmium in biological samples using graphite furnace atomic absorption spectrometry. Escherichia coli (E. coli) was chosen as model substance for this purpose as it is readily available in most laboratories and can be quickly and easily prepared with a high turnaround rate. Four different sample preparation methods were initially evaluated with respect to percent recovery, limit of detection, and limit of quantification, and the most promising one was developed further. The final process involving microwave assisted digestion of the sample with nitric acid …


Vitamin D Supplementation For The Treatment Of Depressive Symptoms In Women With Type 2 Diabetes: A Randomized Clinical Trial, Sue Penckofer Phd, Monique Ridosh, William Howard Adams, Meghan Grzesiak, Jennifer Woo, Mary Byrn, Joanne Kouba Phd, Rdn, Ldn, Patricia M. Sheean, Colleen Kordish, Ramon Durazo-Arvizu, Diane Wallis, Mary Ann Emanuele, Angelos Halaris Mar 2022

Vitamin D Supplementation For The Treatment Of Depressive Symptoms In Women With Type 2 Diabetes: A Randomized Clinical Trial, Sue Penckofer Phd, Monique Ridosh, William Howard Adams, Meghan Grzesiak, Jennifer Woo, Mary Byrn, Joanne Kouba Phd, Rdn, Ldn, Patricia M. Sheean, Colleen Kordish, Ramon Durazo-Arvizu, Diane Wallis, Mary Ann Emanuele, Angelos Halaris

Nursing: School of Nursing Faculty Publications and Other Works

Aim. To determine the efficacy and safety of vitamin D3 supplementation in reducing depressive symptoms in women with type 2 diabetes (T2D), depression, and low vitamin D. Methods. In this double-blind randomized active comparator-controlled trial, women with significant depressive symptoms as assessed by the Center for Epidemiologic Studies Depression (CES-D) scale received weekly oral vitamin D3 supplementation (50,000 IU) or an active comparator (5,000 IU) for 6 months. Assessments of vitamin D, 25-hydroxyvitamin D [25 (OH) D], and depression were measured at baseline, 3 months, and 6 months. Results. A total of 129 women were …


Trajectories Of Self-Management And Independence In Youth With Spina Bifida: Demographic Predictors Of Growth, Monique M. Ridosh, William Adams, Fabiola Magana, Kathleen J. Sawin, Grayson N. Holmbeck Jan 2022

Trajectories Of Self-Management And Independence In Youth With Spina Bifida: Demographic Predictors Of Growth, Monique M. Ridosh, William Adams, Fabiola Magana, Kathleen J. Sawin, Grayson N. Holmbeck

Nursing: School of Nursing Faculty Publications and Other Works

Aim: The purpose of this study was to examine the trajectories of condition and independent living self-management in youth with spina bifida (SB). MethodsA diverse sample of adolescents and young adults (AYAs) with SB completed the Adolescent/Young Adult Self-Management and Independence Scale (AMIS-II) across four time points. Parents reported on demographic characteristics including age, sex, race/ethnicity, and family income. Growth in self-management and its subscales (condition and independent living) were estimated using linear mixed-effect models as a function of respondents' demographics.ResultsThis study included 99 respondents age 18 to 27 years old. About half were female (52.5%) and White (52.5%); 15.2% …


Preexisting Psychological Illness And Its Association With Mortality In Lung Cancer Patients With Access To Support Resources, Allison E. Wright, Elycee Sheehan, Fares Qeadan, Lily Stalter, Ali Imran Saeed Jan 2022

Preexisting Psychological Illness And Its Association With Mortality In Lung Cancer Patients With Access To Support Resources, Allison E. Wright, Elycee Sheehan, Fares Qeadan, Lily Stalter, Ali Imran Saeed

Parkinson School of Health Sciences and Public Health

Abstract Introduction: Diagnosis of lung cancer often results in tremendous stress for most patients, especially in patients with underlying psychological illness. Psy- chosocial support (consultation with psychologist, psychotherapist, or social worker) referral is considered standard for quality cancer care; however, which patients utilize these resources and how these resources affect patient out- comes remain unclear. Objectives: We aimed to identify which newly diagnosed lung cancer patients accessed available psychosocial resources and assessed how utilization of these resources correlated with treatment and survival outcomes. Methods: Data were collected from National Cancer Institute-designated can- cer center at the University of New Mexico. …


A Flexible Mixed-Data Model Applied To Claims Data For Post-Market Surveillance Of Prescription Drug Safety Behavior, Harris Butler, John D. Rice, Nichole E. Carlson, Elaine H. Morrato Jan 2022

A Flexible Mixed-Data Model Applied To Claims Data For Post-Market Surveillance Of Prescription Drug Safety Behavior, Harris Butler, John D. Rice, Nichole E. Carlson, Elaine H. Morrato

Parkinson School of Health Sciences and Public Health

We develop a new modeling framework for jointly modeling first prescription times and the presence of risk-mitigating behavior for prescription drugs using real-world data. We are interested in active surveillance of clinical quality improvement programs, especially for drugs which enter the market under an FDA-mandated Risk Evaluation and Mitigation Strategy (REMS). Our modeling framework attempts to jointly model two important aspects of prescribing, the time between a drug's initial marketing and a patient's first prescription of that drug, and the presence of risk-mitigating behavior at the first prescription. First prescription times can be flexibly modeled as a mixture of component …