Medicine and Health Sciences Commons^™

Underreporting Of Patient-Reported Outcomes In Myeloproliferative Neoplasms Clinical Trials, Anthony Messina, Quentin O'Brien

Clinical Research and Leadership Faculty Posters and Presentations

Introduction

Improvements in overall survival (OS) and quality of life (QoL) are clinically relevant outcomes that should guide clinical decision-making. Patients with MPNs can live with their disease for a long period of time, which increases the importance of understanding the impact of treatment in regards to a patients’ Health-Related QoL. Therefore, including PROs in clinical trials has become paramount in facilitating informed treatment decisions made by health care providers and patients. Furthermore, the FDA encourages the implementation of patient-centric measures in clinical trials.

Objective

We aimed to evaluate the frequency at which PRO measures are utilized as study endpoints …

Himmelfarb Library Liaison Letter - December 2019, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Optocardiography And Electrophysiology Studies Of Ex Vivo Langendorff-Perfused Hearts., Luther M. Swift, Rafael Jaimes Iii, Damon Mccullough, Morgan Burke, Marissa Reilly, Takuya Maeda, Hanyu Zhang, Nobuyuki Ishibashi, Jack M. Rogers, Nikki Gillum Posnack

Pediatrics Faculty Publications

No abstract provided.

Himmelfarb Library Liaison Letter - November 2019, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Himmelfarb Headlines - November/December 2019, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News and information about Himmelfarb Health Sciences Library of interest to users.

After The Flood: Disaster As A Collections Management Opportunity, Sara Hoover, Jolinda Thompson

Himmelfarb Library Faculty Posters and Presentations

No abstract provided.

Joining A Large Academic Consortium: Benefits And Challenges For A Health Sciences Library, Jolinda Thompson, Laura Abate, Ruth Bueter, Sara Hoover

Himmelfarb Library Faculty Posters and Presentations

No abstract provided.

Full-Text Fast: Bouncing Back From The Loss Of Linkout, Laura Abate, Jolinda Thompson

Himmelfarb Library Faculty Posters and Presentations

No abstract provided.

Medicine + Health Magazine, Fall 2019, George Washington University, School Of Medicine And Health Sciences, Office Of Communications And Marketing

Medicine + Health Magazine

No abstract provided.

Creation Of A Health And Wellness And Self Care Tool For Mothers Of Infants Requiring A Neonatal Intensive Care Unit Stay, Genevieve Maccarthy

Doctor of Occupational Therapy Capstone Projects

Purpose: Despite occupational therapy’s established role in the neonatal intensive care unit (NICU) in providing family centered intervention, mothers continue to report lack of readiness to discharge home and emotional distress while in the NICU and upon discharge home. Occupational therapists have the unique skillset to promote engagement in meaningful activities and facilitate overall health and wellness for mother’s during and after their NICU stay.

Method: A qualitative survey was distributed to a convenience sample of fifteen participants to identify emotional experiences in the NICU, how these experiences impact each mother fulfilling her role as a primary caretaker, and the …

A Discharge Checklist To Combat Patient Readmission: A Case Study In A Skilled Nursing Facility, Shaylin O’Connell

Doctor of Occupational Therapy Capstone Projects

A Discharge Checklist to Combat Patient Readmission: A Case Study in a Skilled Nursing Facility focuses on the creation of a discharge checklist, as an intervention, to increase the competency for occupational therapists working in skilled nursing facilities discharging clients back to their home environment. A SNF (Skilled Nursing Facility) provides post-acute healthcare services and rehabilitation for patients following a hospitalization prior to discharging home (Burke et al., 2017). This case study for clinical improvement uses the DMAIC (define, measure, analyze, improve, control) quality model and a multiple case study research design for evaluation. The goal of the quality improvement …

Neurotransmitter, Fall 2019, George Washington Institute For Neuroscience Neurological Institute, George Washington University Hospital

Neurotransmitter

No abstract provided.

Himmelfarb Library Liaison Letter - October 2019, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Gw Nursing, Fall 2019, George Washington University, School Of Nursing

GW Nursing Magazine

No abstract provided.

Using Active Learning Methods, Adult Learning Principles And The Identification Of Critical To Quality (Ctq) Factors To Create Effective Site Staff Training Plans And Improve Quality Risk Management, Kathleen A. Thoma

Clinical Research and Leadership Faculty Posters and Presentations

Objective: The objective of this poster presentation is to help sponsors, monitors and clinical research site managers design and conduct more meaningful and effective site staff training activities in order to enhance the implementation of study protocols in accordance with the investigational plan and thus improve quality risk management.

Content: The U.S. Food and Drug Administration (FDA), the International Council on Harmonization (ICH) and the European Medicines Agency (EMA) emphasize that sponsors should choose investigators, clinical research site staff and monitors that are qualified by education, training and experience. In addition, these entities have taken a more risk-based approach to …

Getting Sexual And Gender Minority Health “Into The Brick And Mortar”: A Mixed Methods Implementation Study, Mandi Pratt-Chapman

Doctor of Philosophy in Translational Health Sciences Dissertations

Sexual and gender minorities (SGM) have unique health risks and health care needs, but medical students receive little training on SGM health (Obedin-Maliver, et al., 2011). This mixed methods study sought to learn from curricular champions in diverse settings to apply lessons learned at the George Washington University (GW). Exploratory models that included eight potential predictor variables for six criterion variables were tested using multiple linear regression. Criterion variables were: knowledge, attitudes, and clinical preparedness measured by the Lesbian, Gay, Bisexual, and Transgender Development of Clinical Skills Scale (LGBT-DOCSS; Bidell, 2017); attitudes measured by the Attitudes Toward LGBT Patients Scale …

Himmelfarb Library Liaison Letter - September 2019, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Himmelfarb Headlines - September/October 2019, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News and information about Himmelfarb Health Sciences Library of interest to users.

Himmelfarb Library Liaison Letter - August 2019, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Co-Crystal Structure Of The Fusobacterium Ulcerans Ztp Riboswitch Using An X-Ray Free-Electron Laser., Christopher Jones, Brandon Tran, Chelsie Conrad, Jason Stagno, Robert Trachman, Pontus Fischer, Alke Meents, Adrian Ferré-D'Amaré

School of Medicine and Health Sciences Student Works

Riboswitches are conformationally dynamic RNAs that regulate gene expression by binding specific small molecules. ZTP riboswitches bind the purine-biosynthetic intermediate 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate (ZMP) and its triphosphorylated form (ZTP). Ligand binding to this riboswitch ultimately upregulates genes involved in folate and purine metabolism. Using an X-ray free-electron laser (XFEL), the room-temperature structure of the Fusobacterium ulcerans ZTP riboswitch bound to ZMP has now been determined at 4.1 Å resolution. This model, which was refined against a data set from ∼750 diffraction images (each from a single crystal), was found to be consistent with that previously obtained from data collected at …

Plasticizer Interaction With The Heart: Chemicals Used In Plastic Medical Devices Can Interfere With Cardiac Electrophysiology., Rafael Jaimes, Damon Mccullough, Bryan Siegel, Luther Swift, Daniel Mcinerney, James Hiebert, Erick A Perez-Alday, Beatriz Trenor, Jiansong Sheng, Javier Saiz, Larisa G Tereshchenko, Nikki Gillum Posnack

Pediatrics Faculty Publications

BACKGROUND: Phthalates are used as plasticizers in the manufacturing of flexible, plastic medical products. Patients can be subjected to high phthalate exposure through contact with plastic medical devices. We aimed to investigate the cardiac safety and biocompatibility of mono-2-ethylhexyl phthalate (MEHP), a phthalate with documented exposure in intensive care patients.

METHODS: Optical mapping of transmembrane voltage and pacing studies were performed on isolated, Langendorff-perfused rat hearts to assess cardiac electrophysiology after MEHP exposure compared with controls. MEHP dose was chosen based on reported blood concentrations after an exchange transfusion procedure.

RESULTS: Thirty-minute exposure to MEHP increased the atrioventricular node (147 …

Himmelfarb Library Liaison Letter - July 2019, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Evidence-Based Practice Initiative For Staff Training To Reduce Adult Psychiatric Inpatient Restraints & Injuries, Mary Leveillee Phd, Rn, Pmhcns-Bc

Doctor of Nursing Practice Projects

Background: Violence against healthcare professionals is a growing phenomenon, and mental health care has the highest risk (Phillips, 2016). The experience of workplace violence is demoralizing, resulting in low job satisfaction, decrease productivity, physical injury, and potential Post-Traumatic Stress Disorder (Phillips, 2016; Howerton & Mentes, 2010). The Joint Commission and The Centers for Medicare and Medicaid identify patient perpetrated violence as a significant workplace risk, and they endorse education and training for risk reduction and safe intervention (The Joint Commission, 2018, 2019).

Objective: The purpose of this evidence-based practice initiative was to evaluate the impact of staff training with the …

Impact Of Telehealth Education Versus Standard Care On Increasing Self-Efficacy Scores And Diabetes Knowledge In Adult Diabetics, Glenda A. Tisdale Msn Rn

Doctor of Nursing Practice Projects

Background: Evidence supports the use of telehealth as an effective method to support the increase in self-efficacy and knowledge among patients with Diabetes Mellitus.

Objectives: This study was to determine whether using telehealth education in conjunction with standard care compared to standard care only, could increase self-efficacy scores and knowledge for adults with diabetes.

Methodology: A randomized, pre-posttest design is used. A convenient sample of 58 adults with self-reported type 2 diabetes were recruited from a faith-based environment. The control group received two 45-minutes standard education sessions about diabetes and diabetes care. The intervention group received weekly smart-phone messaging for …

Change Agent Impact On Pain Management Experience Through Lavender Aromatherapy: Evidence-Based Practice Project, Karen Mack Ms, Mba, Aprn, Rn-Bc, Ccns, Acnpc

Doctor of Nursing Practice Projects

Inadequately controlled acute pain is a problem for hospitalized patients. Non-pharmacological pain management interventions (NPPMIs) are recommended but underutilized. Nurse-directed lavender aromatherapy is a feasible and effective NPPMI. Patients at a community hospital, including its surgical-orthopedic unit, reported lower patient pain management experience scores than the average score of Magnet Recognition status hospitals. The community hospital planned to improve pain management by implementing nurse-directed lavender aromatherapy. The purpose of this evidence-based practice project was to fortify the hospital’s nurse-directed lavender aromatherapy implementation with change agents. A logic model guided implementation. Project aims were to increase the surgical-orthopedic unit’s pain management …

Himmelfarb Library Liaison Letter - June 2019, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Factors Related To Icu Admissions Of Childhood Cancer Patients In Tertiary Preferred Hospital In The Private Sector Of India, Harleen Marwah, Ramandeep Arora

GW Research Days 2016 - 2020

This study was performed to assess the predictive factors of Intensive Care Units (ICU) admission in newly diagnosed pediatric oncologic patients and in patients under ongoing oncologic treatment. Methods used to explore the research question included a retrospective analysis of children admitted to the ICU of the MAX Saket Superspecialty Hospital between March 1, 2013 and May 2018 in order to identify those patients with an oncologic condition who were admitted to an ICU. This subgroup was further evaluated for factors associated to ICU admissions, including: diagnosis, risk factors, complications leading to Pediatric ICU (PICU) admission, PICU therapy, and mortality …

Intimate Partner Violence Curriculum At Gw, Brynne Ichiuji, Jim Blatt

GW Research Days 2016 - 2020

Domestic violence is identified as a global epidemic, where 1 in 3 women throughout the world will experience physical and/or sexual violence (WHO 2013). Medical education research around the world has included DV curriculum studies to determine how to most effectively train medical students to understand, screen, and manage DV (Wathen et al. 2009)(Daniel and Milligan 2013)(Ogunsiji and Clisdell 2017). However, the published studies target varying healthcare specialities, trainee age groups, and study design, thus rendering comparison of specific curriculum inclusions statistically unattainable. Instead, this literature review identified common themes in the conclusions drawn from various studies to isolate reasonable, …

“Unprecedented Times”: The Impact Of Funding Structure On Grant Projects Through The Violence Against Women Act, Amanda Guiliano

GW Research Days 2016 - 2020

Millions of dollars in grants are awarded annually through the Violence Against Women Act (VAWA). This study examined the impact of the funding structure on program implementation, both for current program periods and over time. A dual-methods survey was sent to recipients of 2018 grants for three programs to identify any modifications made to the planned programs due the project period length and potentially unreliable funding. Anticipated results are that grant recipients with the shortest project periods will be more likely to have made program modifications due to project length, and organizations that have received VAWA grants over multiple years …

Intersex Wildlife As Sentinels For Human Health And Endocrine Disruption Near Superfund Sites: A Systematic Review, Olivia Anderson, Melissa Perry

GW Research Days 2016 - 2020

Fish and wildlife are often used as sentinels for human health. This systematic review examines one aspect of wildlife health, intersex (both ovarian and testicular tissue) animals and their prevalence or severity near Superfund sites (EPA designated toxic waste sites). The body of evidence demonstrates some evidence of this indicator and more research is needed, specifically a meta-analysis that is outside the scope of this study.