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Articles 571 - 600 of 4977
Full-Text Articles in Medicine and Health Sciences
Exploring Behavioural Motivations Of Treatment Refusal In Cancer: A Q-Methodological Approach, Ruby Koyllor A. Gleeson, Nicolas H. Hart, Darren Haywood, Frank D. Baughman
Exploring Behavioural Motivations Of Treatment Refusal In Cancer: A Q-Methodological Approach, Ruby Koyllor A. Gleeson, Nicolas H. Hart, Darren Haywood, Frank D. Baughman
Research outputs 2022 to 2026
Background: Cancer treatment refusal is known to lower survival rates and increase cancer symptoms in individuals with cancer. Behavioural motivations of treatment refusal need to be elucidated for better cancer care. Using Q-methodology, a mixed methods research approach, we explored behavioural motivations of treatment refusal in individuals diagnosed with cancer. Method: Thirty-nine individuals (n = 39; age = 49.2 ± 12.2 years) were recruited from Australia, the UK, and the USA, who had refused cancer treatment within the past decade. Participants completed an online demographic questionnaire and a Q-sort activity which required the organisation and ranking of 44 statements on …
Restricting Outdoor Advertising Of Unhealthy Food: Can Australia's Food Category-Based Classification System Be Applied Consistently?, Clare Whitton, Frith Klug, Alexia Bivoltsis, Georgina S.A. Trapp, Claire E. Pulker
Restricting Outdoor Advertising Of Unhealthy Food: Can Australia's Food Category-Based Classification System Be Applied Consistently?, Clare Whitton, Frith Klug, Alexia Bivoltsis, Georgina S.A. Trapp, Claire E. Pulker
Research outputs 2022 to 2026
Most outdoor food advertising (e.g. billboards and bus stops) features foods that are considered unhealthy. The most important technical challenge when designing policies to restrict unhealthy outdoor food advertising is defining 'unhealthy food'. To date, most restriction policies have used nutrient profiling models (i.e. foods are classified according to their nutritional composition) to determine which foods and beverages may be advertised. In Australia, state governments have endorsed a food category-based classification system, with no prescribed nutrient limits, which may create ambiguity when multiple users are identifying food advertisements to be restricted. This study aimed to assess the consistency of decisions …
The Cortical Motor Map For The Extensor Digitorum Communis Muscle Fails To Increase In Treatment-Related Clinically Significant Upper Limb Post-Stroke Recovery, Tomoko Kitago, Joshua Silverstein, Michael B. Gerber, Charlene Thomas, Linda M. Gerber, Gary W. Thickbroom, Dylan J. Edwards
The Cortical Motor Map For The Extensor Digitorum Communis Muscle Fails To Increase In Treatment-Related Clinically Significant Upper Limb Post-Stroke Recovery, Tomoko Kitago, Joshua Silverstein, Michael B. Gerber, Charlene Thomas, Linda M. Gerber, Gary W. Thickbroom, Dylan J. Edwards
Research outputs 2022 to 2026
Objectives: Cortical reorganization has been proposed as a mechanism for motor recovery of the upper limb. The objective of this study was to determine if intervention-related clinical improvement in post-stroke hemiparesis is associated with enlarged motor cortex representation. Methods: Data were analyzed from a single site subset of the NICHE trial. Clinical assessments of upper limb movement (Fugl-Meyer Upper Extremity Motor Assessment, FM-UE, Action Research Arm Test, ARAT, and Wolf Motor Function Test, WMFT) and transcranial magnetic stimulation (TMS) motor mapping of the extensor digitorum communis (EDC) muscle were performed in 23 participants (3–12 months post-stroke, 10 female, 40–88 yrs) …
Endogenous Analgesia, Assessed Via Conditioned Pain Modulation, Is Not Different In People With Hip Osteoarthritis Compared To Controls: A Cross-Sectional Study, Myles C. Murphy, Molly Coventry, Ebonie K. Rio, Paola T. Chivers, Benedict Wand, Gordon Waddington, Andrea B. Mosler
Endogenous Analgesia, Assessed Via Conditioned Pain Modulation, Is Not Different In People With Hip Osteoarthritis Compared To Controls: A Cross-Sectional Study, Myles C. Murphy, Molly Coventry, Ebonie K. Rio, Paola T. Chivers, Benedict Wand, Gordon Waddington, Andrea B. Mosler
Research outputs 2022 to 2026
Background: In people with knee osteoarthritis, measures of pain sensitivity have been demonstrated to relate to both pain severity and treatment outcomes, dependent on the type of pain sensitivity being tested. Objective: Quantify if differences in the pressure pain thresholds (PPT) or conditioned pain modulation (CPM) effect exist between people with hip osteoarthritis and age-matched controls without hip osteoarthritis. Methods: We performed a cross-sectional study across two geographic locations. PPTs at a local (hip) and remote (elbow) site were collected via a manual algometer. CPM was quantified using PPTs immediately prior to, and during ice water immersion of the hand …
A Single Bout Of Resistance Or High-Intensity Interval Training Increases Anti-Cancer Myokines And Suppresses Cancer Cell Growth In Vitro In Survivors Of Breast Cancer, Francesco Bettariga, Dennis R. Taaffe, Cristina Crespo-Garcia, Timothy D. Clay, Mauro De Santi, Giulia Baldelli, Sanjeev Adhikari, Elin S. Gray, Daniel A. Galvão, Robert U. Newton
A Single Bout Of Resistance Or High-Intensity Interval Training Increases Anti-Cancer Myokines And Suppresses Cancer Cell Growth In Vitro In Survivors Of Breast Cancer, Francesco Bettariga, Dennis R. Taaffe, Cristina Crespo-Garcia, Timothy D. Clay, Mauro De Santi, Giulia Baldelli, Sanjeev Adhikari, Elin S. Gray, Daniel A. Galvão, Robert U. Newton
Research outputs 2022 to 2026
Purpose: Breast cancer is the leading cause of cancer-related death in women, highlighting the need for strategies to mitigate recurrence and mortality. We examined the effects of a single bout of resistance training (RT) versus high-intensity interval training (HIIT) on anti-cancer myokines and in vitro cancer cell suppression. Methods: Thirty-two survivors of breast cancer were randomly allocated to a single bout of RT (n = 16) or HIIT (n = 16). Blood was collected before, immediately post (0P) and 30 min post (30P) exercise. We measured serum levels of decorin, interleukin 6 (IL-6), secreted protein acidic and rich in cysteine …
Compassionate Self-Care For Nurses And Midwives: A Sequential Explanatory Mixed Methods Study, Mary Steen, Shwikar Othman, Jennifer Fereday, Annette Briley, Qunyan Xu, Rachael Vernon
Compassionate Self-Care For Nurses And Midwives: A Sequential Explanatory Mixed Methods Study, Mary Steen, Shwikar Othman, Jennifer Fereday, Annette Briley, Qunyan Xu, Rachael Vernon
Research outputs 2022 to 2026
Background: Awareness of being kind and compassionate to yourself is often overlooked despite emerging evidence that high levels of self-compassion decrease levels of anxiety and improves well-being. Aim: To explore what being compassionate to yourself means to nurses and midwives and increase knowledge and understanding of how self-compassion may enhance well-being. Methods: Mixed methods study design was utilised to investigate and explore the influence of self-compassion on nurses and midwives' well-being. Phase 1 involved quantitative data collection and analysis. Phase 2 qualitative data were collected to expand on quantitative results. Results: Fifty-four participants responded to a pre-workshop questionnaire, 55 completed …
Discordance Of Small Dense Ldl Cholesterol Beyond Ldl Cholesterol Or Non–Hdl Cholesterol And Carotid Plaque, Jinqi Wang, Xiaoyu Zhao, Yanchen Zhao, Rui Jin, Yunfei Li, Jiahe Wang, Yueruijing Liu, Zhiyuan Wu, Xiuhua Guo, Lixin Tao
Discordance Of Small Dense Ldl Cholesterol Beyond Ldl Cholesterol Or Non–Hdl Cholesterol And Carotid Plaque, Jinqi Wang, Xiaoyu Zhao, Yanchen Zhao, Rui Jin, Yunfei Li, Jiahe Wang, Yueruijing Liu, Zhiyuan Wu, Xiuhua Guo, Lixin Tao
Research outputs 2022 to 2026
Background: Different low-density lipoprotein (LDL) particles exhibit distinct proatherogenic properties. Objectives: This study sought to evaluate associations of small dense low-density lipoprotein cholesterol (sdLDL-C), large buoyant low-density lipoprotein cholesterol (lbLDL-C), sdLDL-C/LDL-C ratio, and sdLDL-C/lbLDL-C ratio with carotid plaque (CP) risk in the general population, and to perform discordance analyses to determine which biomarker better reflects CP risk beyond low-density lipoprotein cholesterol (LDL-C) and non–high-density lipoprotein cholesterol (non-HDL-C). Methods: This study enrolled 20,369 participants from Beijing Health Management Cohort. Discordant sdLDL-C, lbLDL-C, or ratio metrics (sdLDL-C/LDL-C and sdLDL-C/lbLDL-C) relative to LDL-C or non-HDL-C, and discordant ratio metrics relative to sdLDL-C, were …
Enhancing Person-Centred Care In The Final Years Of Life: Insights From Emergency Department Visits And Hospitalisations In Victorian Residential Aged Care (2015/16 To 2022/23), Janine J. Alan, Bridget Laging, Peter Cameron, Rohan Laging, James Boyd, Davina Porock, Sean Randall
Enhancing Person-Centred Care In The Final Years Of Life: Insights From Emergency Department Visits And Hospitalisations In Victorian Residential Aged Care (2015/16 To 2022/23), Janine J. Alan, Bridget Laging, Peter Cameron, Rohan Laging, James Boyd, Davina Porock, Sean Randall
Research outputs 2022 to 2026
Objective: To explore emergency hospitalisations from Victorian residential aged care facilities (RACFs). Methods: Retrospective descriptive study of Victorian RACFs transfers to ED from 2015/16 to 2022/23. Main outcome measures: (1) ED event rate per 100 RACF beds; (2) Number of ED events, day/time, triage category, reason, comorbidity profile, length of stay, death within 12 months of ED presentation and costs; (3) Relationship between resident characteristics and total ED events; (4) Number of inpatient events, comorbidity profile, length of stay, intensive care use, preventable hospitalisations, diagnosis-related group, deaths and costs. Results: The rate of ED presentations from Victorian RACFs from 2015/16 …
The Moderating Effect Of Dietary Patterns On The Association Of Depression And Anxiety With Cognitive Function, Hilal Salim Said Al Shamsi, Samantha L. Gardener, Hamid R. Sohrabi, Kevin Taddei, Colin L. Masters, Stephanie R. Rainey-Smith, Ralph N. Martins, W. M.A.D.B. Fernando
The Moderating Effect Of Dietary Patterns On The Association Of Depression And Anxiety With Cognitive Function, Hilal Salim Said Al Shamsi, Samantha L. Gardener, Hamid R. Sohrabi, Kevin Taddei, Colin L. Masters, Stephanie R. Rainey-Smith, Ralph N. Martins, W. M.A.D.B. Fernando
Research outputs 2022 to 2026
Background and aims: Investigating modifiable risk factors, such as diet, is crucial in understanding their effects on the relationship between Alzheimer's disease (AD)-related cognitive decline and related conditions. This study assesses whether dietary patterns moderate the relationship between symptoms of depression, anxiety, and cognitive function in older adults. Given that biological and psychosocial differences between sexes may influence dietary behaviours, mental health symptoms, and cognitive outcomes, conducting sex-stratified analyses will allow for identification of differential associations. Method: Cross-sectional data from cognitively unimpaired older adults (n = 1174, age ≥60 years) from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study were …
Blood Biomarkers Of Alzheimer's Disease In Australians Habitually Consuming Various Plant-Based Diets, Shaun Eslick, Grace Austin, Jessica J.A. Ferguson, Manohar L. Garg, Christopher Oldmeadow, Ralph N. Martins
Blood Biomarkers Of Alzheimer's Disease In Australians Habitually Consuming Various Plant-Based Diets, Shaun Eslick, Grace Austin, Jessica J.A. Ferguson, Manohar L. Garg, Christopher Oldmeadow, Ralph N. Martins
Research outputs 2022 to 2026
Background: Evidence suggests that plant-based diets (PBDs) may be protective against neurodegenerative diseases such as Alzheimer's disease (AD). Objective: This study examined associations between blood-based AD biomarkers in individuals 30–75 years without current or diagnosed cardiovascular disease following different PBDs versus regular meat-eating diets (RMEs). Methods: This secondary analysis of the Plant-based Diets study measured Aβ1–42/Aβ1–40, p-tau181, NFL, and GFAP in 237 plasma samples using SIMOA from individuals following vegan, pesco-vegetarian (PVs), lacto-ovo vegetarian (LOVs), semi-vegetarian (SVs), or RME diets. Multivariable regression adjusted for age and sex. Results: Following adjustments for age and sex, plasma Aβ1–42/Aβ1–40ratio was significantly higher in …
Caring For Home Care Workers: Health And Safety Hazards, Harms And Risk Factors, Denise M. Jepsen, Sanetta Henrietta Johanna Du Toit, Toni Robyn Barker, Saul Wodak, Erin Lawn, Tash Freeburn, Josh Rhee, Carmel Laragy, Elizabeth Convery
Caring For Home Care Workers: Health And Safety Hazards, Harms And Risk Factors, Denise M. Jepsen, Sanetta Henrietta Johanna Du Toit, Toni Robyn Barker, Saul Wodak, Erin Lawn, Tash Freeburn, Josh Rhee, Carmel Laragy, Elizabeth Convery
Research outputs 2022 to 2026
Home care workers support the growing number of older adults or people with disabilities who are living at home in their own private residences. The complex and varied work health and safety (WHS) hazards these workers face on the job include both physical and psychosocial harms. While physical WHS hazards in this sector have been articulated, there is an urgent need to update, understand and address psychosocial risks such as verbal abuse and sexually inappropriate behaviour and bullying, particularly when perpetrated by clients. This study sought to identify the range of WHS hazards and harms that home care workers face …
Exercise Perceptions In People With Metabolic Dysfunction-Associated Steatotic Liver Disease: Insights From A Qualitative Study, Kedar Deshpande, John Olynyk, Oyekoya Ayonrinde, Kazunori Nosaka
Exercise Perceptions In People With Metabolic Dysfunction-Associated Steatotic Liver Disease: Insights From A Qualitative Study, Kedar Deshpande, John Olynyk, Oyekoya Ayonrinde, Kazunori Nosaka
Research outputs 2022 to 2026
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver condition associated with lifestyle and metabolic risk factors. While exercise is a beneficial treatment strategy, many patients struggle to implement and perform exercise regularly. It is important for practitioners to know about patient awareness, attitudes, and preferences regarding exercise in the con-text of MASLD. In this study, we examined exercise knowledge, attitudes, and exercise preferences among patients with MASLD to improve their exercise behavior changes. Methods: We conducted a questionnaire and semi-structured inter-view study in adults with MASLD to assess their disease awareness, perspectives on exercise and exercise preferences. …
Longitudinal Changes In Skeletal Muscle In Children Undergoing Cancer Treatment: A Systematic Review And Meta-Analysis, Anna Maria Markarian, Dennis R. Taaffe, Daniel A. Galvão, Carolyn J. Peddle-Mcintyre, Jodie Cochrane Wilkie, Francesco Bettariga, Robert U. Newton
Longitudinal Changes In Skeletal Muscle In Children Undergoing Cancer Treatment: A Systematic Review And Meta-Analysis, Anna Maria Markarian, Dennis R. Taaffe, Daniel A. Galvão, Carolyn J. Peddle-Mcintyre, Jodie Cochrane Wilkie, Francesco Bettariga, Robert U. Newton
Research outputs 2022 to 2026
Skeletal muscle loss during chemotherapy has been associated with poorer outcomes and reduced survival across several types of cancer. However, the extent and progression of muscle loss during treatment for childhood cancers remain unclear. A better understanding could help identify children at increased risk and inform the timing of targeted intervention. This systematic review and meta-analysis aimed to synthesize the evidence on skeletal muscle changes during treatment for childhood cancers and identify factors that influence these outcomes. A systematic search was conducted in CINAHL, Embase, PubMed, SPORTDiscus, and Web of Science. Studies were eligible if they included children and adolescents …
Management Of Neonates In The Special Care Nursery And Its Impact On The Developing Gut Microbiota: A Comprehensive Clinical Review, Ravisha Srinivasjois, Shripada Rao, Gavin Pereira
Management Of Neonates In The Special Care Nursery And Its Impact On The Developing Gut Microbiota: A Comprehensive Clinical Review, Ravisha Srinivasjois, Shripada Rao, Gavin Pereira
Research outputs 2022 to 2026
The first few days following the birth are a vulnerable time for the neonate. Sick infants experience various interventions during their stay in the neonatal unit in order to stay alive and grow. Acquisition of gut microbes is critical for the short- and long-term health of the neonate. At a time when the gut microbiome is starting to take shape, crucial interventions directed at improving the growth, development and survival of the neonate impact its development. Events prior to and after the birth of the neonate, such as maternal conditions, antibiotic exposure, type of feeds, supplemental probiotics, and neonatal intensive …
Nut Intake, Functional Limitations, And Quality Of Life In Older Adults: Findings From Nhanes 2003–2012, Ilili Feyesa, Elena S. George, David Scott, Gavin Abbott, Jeew Hettiarachchi, Robin M. Daly, Jack Dalla Via, Ekavi N. Georgousopoulou, Sze Yen Tan
Nut Intake, Functional Limitations, And Quality Of Life In Older Adults: Findings From Nhanes 2003–2012, Ilili Feyesa, Elena S. George, David Scott, Gavin Abbott, Jeew Hettiarachchi, Robin M. Daly, Jack Dalla Via, Ekavi N. Georgousopoulou, Sze Yen Tan
Research outputs 2022 to 2026
Background: Increased nut consumption has positive effects on physical and cognitive function, but whether these translate into lower functional limitations in older adults is unknown. The aim of this study was to investigate the association between nut intake, functional limitations, the severity of these limitations and health-related quality of life (HRQOL) in older adults. Methods: This cross-sectional study included data from 5807 adults (53.4% female) aged 60 years and older who participated in the US National Health and Nutrition Examination Survey (NHANES) between 2003 and 2012. Nut intake was assessed using two 24-h dietary recalls. Functional limitations were assessed using …
The Role Of Diet In Moderating The Relationship Between Symptoms Of Depression And Brain Amyloid Load, Hilal Salim Said J. Al Shamsi, Samantha L. Gardener, Stephanie R. Rainey-Smith, Hamid R. Sohrabi, Kevin C.M. Taddei, Colin L. Masters, Vincent M. Doré, Christopher L. Rowe, W. M.A.D.Binosha Fernando, Ralph N. Martins
The Role Of Diet In Moderating The Relationship Between Symptoms Of Depression And Brain Amyloid Load, Hilal Salim Said J. Al Shamsi, Samantha L. Gardener, Stephanie R. Rainey-Smith, Hamid R. Sohrabi, Kevin C.M. Taddei, Colin L. Masters, Vincent M. Doré, Christopher L. Rowe, W. M.A.D.Binosha Fernando, Ralph N. Martins
Research outputs 2022 to 2026
Background: Healthy lifestyle factors, including diet, may affect brain amyloid beta (Aβ) load. This study examines dietary patterns as moderators of the relationships among symptoms of depression, anxiety, and brain Aβ load. Method: A cross-sectional study of cognitively unimpaired older adults (n = 524) from the Australian Imaging, Biomarkers, and Lifestyle study assessed dietary patterns, depressive and anxiety symptoms, and brain Aβ load. Moderation and simple slope analyses were conducted. Results: The Dietary Approaches to Stop Hypertension (DASH) diet moderated the relationship between depressive and anxiety symptoms and brain Aβ load. Higher symptoms were associated with greater Aβ load in …
Understanding The Role Of Sports Injury Management By Australian Osteopaths: A Cross Sectional Survey Of 992 Practitioners, Brett Vaughan, Jon Adams, Wenbo Peng, Lauren V. Fortington, Michael Fleischmann, Kylie Fitzgerald, Amie Steel, David Sibritt
Understanding The Role Of Sports Injury Management By Australian Osteopaths: A Cross Sectional Survey Of 992 Practitioners, Brett Vaughan, Jon Adams, Wenbo Peng, Lauren V. Fortington, Michael Fleischmann, Kylie Fitzgerald, Amie Steel, David Sibritt
Research outputs 2022 to 2026
Sport-related injuries are common presentations to primary care and hospital settings. Australian osteopaths practice mainly in private clinical settings in which the frequency of sport-related injury presentations, and how these injuries are managed, is unknown. The objective of the study was to describe the demographic, practice, and clinical management characteristics of Australian osteopaths who report often treating sport-related injuries. The study is a secondary analysis of data derived from the Australian osteopathy practice-based research network. Respondents indicated the frequency treating sports-related injuries in addition to other demographic, practice, and patient management characteristics. Backward logistic regression identified significant characteristics associated with …
A Flavonoid-Rich Diet Is Associated With A Lower Risk Of Chronic Kidney Disease: A Prospective Cohort Study, William Bell, Alysha S. Thompson, Nicola P. Bondonno, Amy Jennings, Martina Gaggl, Tilman Kühn, Aedín Cassidy
A Flavonoid-Rich Diet Is Associated With A Lower Risk Of Chronic Kidney Disease: A Prospective Cohort Study, William Bell, Alysha S. Thompson, Nicola P. Bondonno, Amy Jennings, Martina Gaggl, Tilman Kühn, Aedín Cassidy
Research outputs 2022 to 2026
Background and aim: Mechanistic data suggests several flavonoids may improve kidney function, but no large-scale prospective cohort study has been conducted. As such, we performed a prospective population-based study on flavonoid intakes, chronic kidney disease (CKD) risk, and all-cause mortality among participants with CKD. Methods: We examined associations between a Flavodiet score (FDS), individual flavonoid-rich foods and subclasses (based on ≥2 24-h dietary assessments) and a) CKD risk among 109,711 adults, and b) all-cause mortality among 3,287 participants with CKD at baseline, aged 40–69 years using multivariable Cox regression analyses. Additionally, we used mediation analysis to examine potential mechanisms of …
Inhibition Of The Caveolin-1 Pathway Promotes Apoptosis And Overcomes Pan-Tyrosine Kinase Inhibitor Resistance In Hepatocellular Carcinoma, Tasnuva D. Kabir, Samuel Beck, Lisa M. Stuart, Ji Li, Rui Hou, Peiwen Liu, Shelby Margolius, Claire Kim, Yu Suk Choi, Edward R. Bastow, Dianne J. Beveridge, Lisa Spalding, Ziyi Li, Florent Ginhoux, Pierce Chow, Michael Phillips, Andrew D. Redfern, George C. Yeoh, Alistair Forrest, Andrew J. Woo, Ankur Sharma, Jacob George, Geoffrey Mccaughan, Peter Leedman
Inhibition Of The Caveolin-1 Pathway Promotes Apoptosis And Overcomes Pan-Tyrosine Kinase Inhibitor Resistance In Hepatocellular Carcinoma, Tasnuva D. Kabir, Samuel Beck, Lisa M. Stuart, Ji Li, Rui Hou, Peiwen Liu, Shelby Margolius, Claire Kim, Yu Suk Choi, Edward R. Bastow, Dianne J. Beveridge, Lisa Spalding, Ziyi Li, Florent Ginhoux, Pierce Chow, Michael Phillips, Andrew D. Redfern, George C. Yeoh, Alistair Forrest, Andrew J. Woo, Ankur Sharma, Jacob George, Geoffrey Mccaughan, Peter Leedman
Research outputs 2022 to 2026
Resistance to multi-tyrosine kinase inhibitors (TKI) is a major clinical concern in advanced hepatocellular carcinoma (HCC). Herein, we aimed to uncover the mechanisms underlying pan-TKI resistance and to identify potential therapeutic targets. We used multiple TKI-resistant HCC cell lines to identify caveolin-1 (CAV1) as a key driver of therapeutic resistance. CAV1 downregulation induced apoptosis, inhibited metastasis and restored TKI sensitivity in both inherent and acquired TKI-resistant HCC cells. Mechanistically, in acquired TKI-resistant cells aberrant CAV1/STAT3/P70S6K signalling is required for their survival, motility, and invasiveness. CAV1 inhibition reduced expression of dormancy regulators E-cadherin, RAC1 and p21, enhanced cancer stemness markers, and …
Atopy-Related Immune Profiles Are Subject To Genetic Influence As Evaluated Using School-Aged Twin Pairs, Jonatan Leffler, James F. Read, Danny Mok, Michael Serralha, Anthony Bosco, Patrick G. Holt, Richard Saffery, Deborah H. Strickland
Atopy-Related Immune Profiles Are Subject To Genetic Influence As Evaluated Using School-Aged Twin Pairs, Jonatan Leffler, James F. Read, Danny Mok, Michael Serralha, Anthony Bosco, Patrick G. Holt, Richard Saffery, Deborah H. Strickland
Research outputs 2022 to 2026
The interaction of genetic and environmental contributions to immunological traits and their association with atopic disease remain unclear. Flow cytometry and in vitro cytokine responses were used to characterize immune profiles from 93 school-aged twin pairs. Using an established twin pair analytical strategy, the genetic and environmental influences on immunological traits were evaluated, along with their association with atopy. Our findings suggest strong genetic influence on several traits, particularly B cell abundance. In contrast, cytokine responses from in vitro stimulations appeared mainly shaped by environmental exposures. Regarding associations with atopy, greater abundance of both B cells and basophils were observed …
Diverse Diagnostic And Management Approaches For Acute Rheumatic Fever In Australia And New Zealand: Findings Of A Prospective Clinical Study, Ruwani Peiris, Rachel Webb, Julie Bennett, Jennifer Yan, Joshua Reginald Francis, Bo Remenyi, Florina Chan Mow, Rachel Burgess, Nigel J. Wilson, Alicia Stanley, Laura Francis, Rhonda Holloway, Roxanne Westbury, Shirley Lawrence, Yolanda Hernandez-Gomez, David Broadhurst, Nicole J. Moreland, Reuben Mcgregor, Caroline Motteram, Glenn Pearson, Mark Mayo, Anna P. Ralph, Jonathan R. Carapetis
Diverse Diagnostic And Management Approaches For Acute Rheumatic Fever In Australia And New Zealand: Findings Of A Prospective Clinical Study, Ruwani Peiris, Rachel Webb, Julie Bennett, Jennifer Yan, Joshua Reginald Francis, Bo Remenyi, Florina Chan Mow, Rachel Burgess, Nigel J. Wilson, Alicia Stanley, Laura Francis, Rhonda Holloway, Roxanne Westbury, Shirley Lawrence, Yolanda Hernandez-Gomez, David Broadhurst, Nicole J. Moreland, Reuben Mcgregor, Caroline Motteram, Glenn Pearson, Mark Mayo, Anna P. Ralph, Jonathan R. Carapetis
Research outputs 2022 to 2026
Objectives To describe diagnostic and management characteristics of acute rheumatic fever (ARF) among participants in the € Searching for a Technology-Driven Acute Rheumatic Fever Test' study, in order to answer clinical questions and determine epidemiological and practice differences in different settings. Design Multisite, prospective cohort study. Setting One hospital in northern Australia and two hospitals in New Zealand, 2018-2021. Participants 143 episodes of definite, probable or possible ARF among 141 participants (median age 10 years, range 5-23; 98% Indigenous). Primary and secondary outcome measures Participant characteristics, clinical, biochemical and echocardiographic data were explored using descriptive data. Associations with length of …
Use Of An Electronic Medication Management Application To Support Pharmacists Review To Optimise Medicines In Residential Aged Care (Prompt-Rc): A Study Protocol For A Parallel Cluster Randomised Controlled Trial, Amy Theresa Page, Dee Mangin, Hend Almutairi, Esa Y.H. Chen, Kenneth Lee, Nagham Ailabouni, Jacinta Johnson, Kathleen Potter, Nahal Mavaddat, Rhonda Marise Clifford, Elton Lobo, Loretta Baldassar, Liza Seubert, Dennis Petrie, Kate Wang, Sarah Hosking, Jenny Tasker, Christopher Etherton-Beer
Use Of An Electronic Medication Management Application To Support Pharmacists Review To Optimise Medicines In Residential Aged Care (Prompt-Rc): A Study Protocol For A Parallel Cluster Randomised Controlled Trial, Amy Theresa Page, Dee Mangin, Hend Almutairi, Esa Y.H. Chen, Kenneth Lee, Nagham Ailabouni, Jacinta Johnson, Kathleen Potter, Nahal Mavaddat, Rhonda Marise Clifford, Elton Lobo, Loretta Baldassar, Liza Seubert, Dennis Petrie, Kate Wang, Sarah Hosking, Jenny Tasker, Christopher Etherton-Beer
Research outputs 2022 to 2026
Introduction Most older adults living in residential aged care facilities (RACFs) have at least one marker of potentially suboptimal prescribing. Pharmacists play a crucial role in medication management, with their effectiveness enhanced by using computerised decision support tools. The Pharmacists Review to Optimise Medicines in Residential Aged Care (PROMPT-RC) study aims to optimise medicine use by providing pharmacists in RACFs with an electronic medicine management app with integrated decision support (AusTAPER App/Pathway) to use as part of medication reviews they undertake. Methods and analysis The PROMPT-RC study is a parallel cluster randomised controlled trial design involving Australian RACFs. It will …
Recruitment And Retention Of Intensive Care Unit Survivors In Follow-Up Studies: A Systematic Review, Beverley Ewens, Vivien Kemp, Yvonne Middlewick, Amanda Towell-Barnard, Lisa Whitehead
Recruitment And Retention Of Intensive Care Unit Survivors In Follow-Up Studies: A Systematic Review, Beverley Ewens, Vivien Kemp, Yvonne Middlewick, Amanda Towell-Barnard, Lisa Whitehead
Research outputs 2022 to 2026
Background: Engaging intensive care unit survivors in research is challenging. Studies have reported recruitment and attrition rates; details are lacking on retention strategies and attrition. Objective: The aim of this study was to explore barriers and enablers to recruitment and retention in research of people post intensive care discharge. Methods: A convergent mixed-method review using the Joanna Briggs Institute (JBI) methodology considered studies that reported on recruitment, retention, and attrition rates of adult post–intensive care survivors in longitudinal studies. CINAHL Ultimate (CINAHL+), PubMed, Excerpta Medica Database (EMBASE), PsycINFO, Scopus, Proquest Health, and Medical Collection were searched in March 2024 using …
Psychological Distress Among Suicide Exposed And Subsequently Bereaved Carers, Myfanwy Maple, Navjot Bhullar, Marie Reid, Sarah Wayland
Psychological Distress Among Suicide Exposed And Subsequently Bereaved Carers, Myfanwy Maple, Navjot Bhullar, Marie Reid, Sarah Wayland
Research outputs 2022 to 2026
People bereaved by suicide are at risk of developing significant mental health issues, including the risk of self-harm. To understand suicide exposure and psychological factors contributing to these adverse outcomes, survey data from 92 participants (Meanage = 53.50 years, SD = 14.5, female = 83.7%) who had provided care to someone who subsequently died by suicide were used. Participants responded to questions relating to suicide exposure, bereavement, suicidal ideation and psychological distress. A hierarchical regression analysis found that the perceived impact of suicide death and one's own suicidal ideation explained 46% variance in psychological distress. Suicide bereaved carers are highly …
The Artichoke Model: A Conceptual Framework For Positive Food Environments In Early Childhood Education And Care (Ecec) Settings, Ros Sambell, Audrey Elford, Tori Overstone, Rebecca Byrne, Kirsty Elliott, Sandra Vale, Penelope Love, Lisa Vincze, Leanne Elliston, Fiona Nave, Janny Goris, Emma Esdaile, Amanda Devine
The Artichoke Model: A Conceptual Framework For Positive Food Environments In Early Childhood Education And Care (Ecec) Settings, Ros Sambell, Audrey Elford, Tori Overstone, Rebecca Byrne, Kirsty Elliott, Sandra Vale, Penelope Love, Lisa Vincze, Leanne Elliston, Fiona Nave, Janny Goris, Emma Esdaile, Amanda Devine
Research outputs 2022 to 2026
The Artichoke Model is a conceptual framework developed to support the understanding of the breadth and influence of food environments in Early Childhood Education and Care (ECEC) settings. It identifies twelve interrelated components spanning food provision, mealtime practices, curriculum integration, staff capacity, family engagement, and systemic enablers such as policy, equity, and environmental sustainability. Represented visually as an artichoke with the child at its centre, the model encourages holistic analysis, recognising that sustainable change requires the interconnected operation of all components, rather than isolated interventions. The Artichoke Model is intended as a tool for researchers, policymakers, and advocates to guide …
Navigating Child Oral Health In Western Australia: A Caregiver's Perspective, Lesley Andrew, Elizabeth Wenden, Mohamed Estai, Ruth Wallace
Navigating Child Oral Health In Western Australia: A Caregiver's Perspective, Lesley Andrew, Elizabeth Wenden, Mohamed Estai, Ruth Wallace
Research outputs 2022 to 2026
Background: Early childhood caries (ECC) is the most common chronic health condition among Australian preschool-aged children. Untreated, ECC can affect children's physical and emotional health and future social opportunities. ECC is largely preventable through primary caregivers' correct understanding of oral health promoting diets, oral hygiene practices and dental service engagement. The study aim is to explore Western Australian (WA) primary caregivers' child oral health knowledge, experience and practices. The Fisher-Owens socioecological model of child oral health was applied across the study to structure and interpret the findings across the complex, interactive sociocultural influences on child oral health. Methods: The mixed-methods …
Translating Advocacy Into Action: Exploring Oncology Healthcare Professionals’ Awareness And Use Of The Clinical Oncology Society Of Australia Position Statement On Exercise In Cancer Care, Jack Dalla Via, Francesca Cehic, Carolyn J. Peddle-Mcintyre, Christopher R. Andrew, David Mizrahi, Yvonne Zissiadis, Nigel A. Spry, Robert U. Newton, Mary A. Kennedy
Translating Advocacy Into Action: Exploring Oncology Healthcare Professionals’ Awareness And Use Of The Clinical Oncology Society Of Australia Position Statement On Exercise In Cancer Care, Jack Dalla Via, Francesca Cehic, Carolyn J. Peddle-Mcintyre, Christopher R. Andrew, David Mizrahi, Yvonne Zissiadis, Nigel A. Spry, Robert U. Newton, Mary A. Kennedy
Research outputs 2022 to 2026
Purpose: The Clinical Oncology Society of Australia (COSA) position statement on exercise in cancer care encourages all healthcare professionals to discuss, recommend, and refer people with cancer to exercise; however, use of these recommendations in practice is unknown. Methods: Oncology healthcare professionals working in Australia were invited to complete a cross-sectional online survey that assessed contextual factors that influence implementation of COSA exercise guidance in cancer care, based on the Consolidated Framework for Implementation Research. Results: We received 133 survey responses. Most were women (74%), nurses (35%), or oncologists (26%), involved in cancer care for > 10 years (63%), and in …
The Association Between Sexually Transmitted Infections And Pregnancy Outcomes In The Northern Territory, Australia: A Population-Based Cohort Study, Jennifer Dunne, Gizachew A. Tessema, Matthew Legge, Sylvester Dodzi Nyadanu, Aditi Roy, Amanuel T. Gebremedhin, Jacqueline Hendriks, Tricia Reid-Moore, Gavin Pereira
The Association Between Sexually Transmitted Infections And Pregnancy Outcomes In The Northern Territory, Australia: A Population-Based Cohort Study, Jennifer Dunne, Gizachew A. Tessema, Matthew Legge, Sylvester Dodzi Nyadanu, Aditi Roy, Amanuel T. Gebremedhin, Jacqueline Hendriks, Tricia Reid-Moore, Gavin Pereira
Research outputs 2022 to 2026
Background: Often asymptomatic in nature, sexually transmitted infections (STIs) are highly prevalent in women of reproductive ages, leading to adverse perinatal outcomes. This study investigated the association between STIs during pregnancy and the risk of adverse perinatal outcomes using comprehensive population-linked data from the Northern Territory (NT), Australia. Methods: This population-based retrospective cohort study examined births (live births and stillbirths) from the NT Perinatal Data Collection and the NT Notifiable Diseases register from 2005 to 2020. All singleton births (N = 59,465) were included, along with infectious disease notifications of four STIs that occurred during pregnancy: chlamydia, gonorrhoea, trichomoniasis, and …
The Effect Of Oral Colchicine And Vitamin K1 On Bone Metabolism In Patients With Diabetes Mellitus: A Post-Hoc Analysis Of A 2 × 2 Factorial Randomized Controlled Trial With 18F-Sodium Fluoride Positron Emission Tomography, Jamie W. Bellinge, Marc Sim, Roslyn J. Francis, Sing Ching Lee, Dick C. Chan, Christian M. Girgis, Gerald F. Watts, Joshua R. Lewis, Carl J. Schultz
The Effect Of Oral Colchicine And Vitamin K1 On Bone Metabolism In Patients With Diabetes Mellitus: A Post-Hoc Analysis Of A 2 × 2 Factorial Randomized Controlled Trial With 18F-Sodium Fluoride Positron Emission Tomography, Jamie W. Bellinge, Marc Sim, Roslyn J. Francis, Sing Ching Lee, Dick C. Chan, Christian M. Girgis, Gerald F. Watts, Joshua R. Lewis, Carl J. Schultz
Research outputs 2022 to 2026
Purpose: Diabetes mellitus (DM) confers an increased risk of fracture. Fracture risk stratification techniques are imperfect, and preventative therapies are sparse. We aimed to describe features associated with a dysfunctional bone metabolism determined by 18F-Sodium Fluoride Positron Emission Tomography (18F-NaF PET) in patients with DM and test the effects of vitamin K1 and colchicine therapy on vertebral 18F-NaF activity. Methods: This is a post-hoc analysis of a 2 × 2 factorial randomized double-blind placebo-controlled trial. Participants aged 50–80 with DM underwent 18F-NaF PET/CT imaging at baseline, 3 months of therapy with vitamin K1 (10mg/daily) or placebo, and colchicine (0.5 mg/day) …
A Perspective Or Review Based Entirely On Low-Quality Evidence Is Simply An Opinion, Matthew S. Tenan, Sophia Nimphius
A Perspective Or Review Based Entirely On Low-Quality Evidence Is Simply An Opinion, Matthew S. Tenan, Sophia Nimphius
Research outputs 2022 to 2026
No abstract provided.