Medicine and Health Sciences Commons^™

Systematic Review Of Clinical Practice Guidelines To Identify Recommendations For Sleep In Type 2 Diabetes Mellitus Management, Aisling Smyth, Mark Jenkins, Melissa Dunham, Yvonne Kutzer, Shahrad Taheri, Lisa Whitehead

Research outputs 2014 to 2021

Introduction

Sleep quality, quantity and timing have been shown to impact glycaemic control, with a role in insulin sensitivity, glucose tolerance and HbA1C levels, in both diabetic and non-diabetic populations. The aim of this study was to identify recommendations for sleep assessment and management in international clinical practice guidelines focused on type 2 diabetes mellitus management in adults.

Study design: Systematic Review.

Methodology

Clinical practice guidelines which focused on the management of type 2 diabetes mellitus in adults were included (n = 35). Two independent reviewers utilised the Appraisal of Guidelines for Research and Evaluation tool (AGREE) II and a …

Muscular And Physical Response To An Agility And Repeated Sprint Tests According To The Level Of Competition In Futsal Players, Jorge García-Unanue, José Luis Felipe, David Bishop, Enrique Colino, Esther Ubago-Guisado, Jorge López-Fernández, Enrique Hernando, Leonor Gallardo, Javier Sánchez-Sánchez

Research outputs 2014 to 2021

© Copyright © 2020 García-Unanue, Felipe, Bishop, Colino, Ubago-Guisado, López-Fernández, Hernando, Gallardo and Sánchez-Sánchez. The aim of this study was to evaluate the neuromuscular response to an agility and repeated sprint ability (RSA) test according to the level of competition in futsal players. A total of 33 players from two elite teams and one amateur team participated in the study. The participants completed an agility t-test, a 30 m-speed test, and a RSA test. A countermovement jump (CMJ) test and a tensiomyography test of the rectus femoris (RF) and biceps femoris (BF) of both legs were carried out before and …

Eftilagimod Alpha, A Soluble Lymphocyte Activation Gene-3 (Lag-3) Protein Plus Pembrolizumab In Patients With Metastatic Melanoma, Victoria Atkinson, Adnan Khattak, Andrew Haydon, Melissa Eastgate, Amitesh Roy, Prashanth Prithviraj, Christian Mueller, Chrystelle Brignone, Frederic Triebel

Research outputs 2014 to 2021

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. BACKGROUND: To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of eftilagimod alpha (efti), a soluble lymphocyte activation gene-3 protein, in combination with the programmed cell death-1 (PD-1) antagonist pembrolizumab. METHODS: The study was divided into two parts; parts A and B, where part A was the dose escalation part and part B was an extension part of the study. Patients with metastatic melanoma were treated with efti plus the standard dose of pembrolizumab. Blood samples were assayed to determine …

Contemporary Epidemiology Of Rising Atrial Septal Defect Trends Across Usa 1991–2016: A Combined Ecological Geospatiotemporal And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2014 to 2021

© 2020, The Author(s). Background: Cardiovascular anomalies are the largest group of congenital anomalies and the major cause of death in young children, with various data linking rising atrial septal defect incidence (ASDI) with prenatal cannabis exposure. Objectives / Hypotheses. Is cannabis associated with ASDI in USA? Is this relationship causal? Methods: Geospatiotemporal cohort study, 1991–2016. Census populations of adults, babies, congenital anomalies, income and ethnicity. Drug exposure data on cigarettes, alcohol abuse, past month cannabis use, analgesia abuse and cocaine taken from National Survey of Drug Use and Health (78.9% response rate). Cannabinoid concentrations from Drug Enforcement Agency. Inverse …

Modification Of Diet, Exercise And Lifestyle (Model) Study: A Randomised Controlled Trial Protocol, Simone Radavelli-Bagatini, Catherine P. Bondonno, Marc Sim, Lauren C. Blekkenhorst, Reindolf Anokye, Emma Connolly, Nicola P. Bondonno, John T. Schousboe, Richard J. Woodman, Kun Zhu, Pawel Szulc, Ben Jackson, James Dimmock, Markus P. Schlaich, Kay L. Cox, Douglas P. Kiel, Wai H. Lim, Mandy Stanley, Amanda Devine, Peter L. Thompson, Jenny Gianoudis, Belinda De Ross, Robin M. Daly, Joshua Lewis, Jonathan M. Hodgson

Research outputs 2014 to 2021

Introduction Most cardiovascular disease (CVD)-related events could be prevented or substantially delayed with improved diet and lifestyle. Providing information on structural vascular disease may improve CVD risk factor management, but its impact on lifestyle change remains unclear. This study aims to determine whether providing visualisation and pictorial representation of structural vascular disease (abdominal aortic calcification (AAC)) can result in healthful diet and lifestyle change.

Methods and analysis This study, including men and women aged 60–80 years, is a 12-week, two-arm, multisite randomised controlled trial. At baseline, all participants will have AAC assessed from a lateral spine image captured using a …

Statements About The Pervasiveness Of Behavior Require Data About The Pervasiveness Of Behavior, Craig P. Speelman, Marek Mcgann

Research outputs 2014 to 2021

Despite recent close attention to issues related to the reliability of psychological research (e.g., the replication crisis), issues of the validity of this research have not been considered to the same extent. This paper highlights an issue that calls into question the validity of the common research practice of studying samples of individuals, and using sample-based statistics to infer generalizations that are applied not only to the parent population, but to individuals. The lack of ergodicity in human data means that such generalizations are not justified. This problem is illustrated with respect to two common scenarios in psychological research that …

Process Data Of Allogeneic Ex Vivo-Expanded Abcb5+ Mesenchymal Stromal Cells For Human Use: Off-The-Shelf Gmp-Manufactured Donor-Independent Atmp, Seda Ballikaya, Samar Sadeghi, Elke Niebergall-Roth, Laura Nimtz, Jens Frindert, Alexandra Norrick, Nicole Stemler, Nicole Bauer, Yvonne Rosche, Vanessa Kratzenberg, Julia Pieper, Tina Ficek, Markus H. Frank, Christoph Ganss, Jasmina Esterlechner, Mark A. Kluth

Research outputs 2014 to 2021

© 2020, The Author(s). Background: Human dermal mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter ABCB5 represent an easily accessible MSC population that, based on preclinical and first-in-human data, holds significant promise to treat a broad spectrum of conditions associated not only with skin-related but also systemic inflammatory and/or degenerative processes. Methods: We have developed a validated Good Manufacturing Practice-compliant expansion and manufacturing process by which ABCB5+ MSCs derived from surgical discard skin tissues are processed to an advanced-therapy medicinal product (ATMP) for clinical use. Enrichment for ABCB5+ MSCs is achieved in a three-step process involving plastic …

Prevalence And Attributable Health Burden Of Chronic Respiratory Diseases, 1990–2017: A Systematic Analysis For The Global Burden Of Disease Study 2017, Joan B. Soriano, Parkes J. Kendrick, Katherine R. Paulson, Vinay Gupta, Elissa M. Abrams, Rufus Adesoji Adedoyin, Tara Ballav Adhikari, Shailesh M. Advani, Anurag Agrawal, Elham Ahmadian, Fares Alahdab, Syed Mohamed Aljunid, Khalid A. Altirkawi, Nelson Alvis-Guzman, Nahla Hamed Anber, Catalina Liliana Andrei, Mina Anjomshoa, Fereshteh Ansari, Josep M. Antó, Jalal Arabloo, Seyyede Masoume Athari, Seyyed Shamsadin Athari, Nefsu Awoke, Alaa Badawi, Joseph Adel Mattar Banoub, Derrick A. Bennett, Isabela M. Bensenor, Kathleen S.Sachiko Berfield, Robert S. Bernstein, Krittika Bhattacharyya, Ali Bijani, Michael Brauer, Gene Bukhman, Zahid A. Butt, Luis Alberto Cámera, Josip Car, Juan J. Carrero, Felix Carvalho, Carlos A. Castañeda-Orjuela, Jee-Young Jasmine Choi, Devasahayam J. Christopher, Aaron J. Cohen, Lalit Dandona, Rakhi Dandona, Anh Kim Dang, Ahmad Daryani, Barbora De Courten, Feleke Mekonnen Demeke, Gebre Teklemariam Demoz, Jan-Walter De Neve, Rupak Desai, Samath Dhamminda Dharmaratne, Daniel Diaz, Abdel Douiri, Tim Robert Driscoll, Eyasu Ejeta Duken, Aziz Eftekhari, Hajer Elkout, Aman Yesuf Endries, Ibtihal Fadhil, Andre Faro, Farshad Farzadfar, Eduarda Fernandes, Irina Filip, Florian Fischer, Masoud Foroutan, M. A. Garcia-Gordillo, Abadi Kahsu Gebre, Ketema Bizuwork Gebremedhin, Gebreamlak Gebremedhn Gebremeskel, Kebede Embaye Gezae, Aloke Gopal Ghoshal, Paramjit Singh Gill, Richard F. Gillum, Houman Goudarzi, Yuming Guo, Rajeev Gupta, Gessessew Bugssa Hailu, Amir Hasanzadeh, Hamid Yimam Hassen, Simon I. Hay, Chi Linh Hoang, Michael K. Hole, Nobuyuki Horita, H. Dean Hosgood, Mihaela Hostiuc, Mowafa Househ, Olayinka Stephen Ilesanmi, Milena D. Ilic, Seyed Sina Naghibi Irvani, Sheikh Mohammed Sharifu Lislam, Mihajlo Jakovljevic, Amr A. Jamal, Ravi Prakash Jha, Jost B. Jonas, Zubair Kabir, Amir Kasaeian, Gebremicheal Gebreslassie Kasahun, Getachew Mullu Kassa, Adane Teshome Kefale, Andre Pascal Kengne, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Ejaz Ahmad Khan, Junaid Khan, Jagdish Khubchandani, Young-Eun Kim, Yun Jin Kim, Sezer Kisa, Adnan Kisa, Luke D. Knibbs, Hamidreza Komaki, Parvaiz A. Koul, Ai Koyanagi, G. Anil Kumar, Qing Lan, Savita Lasrado, Paolo Lauriola, Carlo La Vecchia, Tham Thi Le, James Leigh, Miriam Levi, Shanshan Li, Alan D. Lopez, Paulo A. Lotufo, Fabiana Madotto, Narayan B. Mahotra, Marek Majdan, Azeem Majeed, Reza Malekzadeh, Abdullah A. Mamun, Navid Manafi, Farzad Manafi, Lorenzo Giovanni Mantovani, Birhanu Geta Meharie, Hagazi Gebre Meles, Gebrekiros Gebremichael Meles, Ritesh G. Menezes, Tomislav Mestrovic, Ted R. Miller, G. K. Mini, Erkin M. Mirrakhimov, Babak Moazen, Karzan Abdulmuhsin Mohammad, Shafiu Mohammed, Farnam Mohebi, Ali H. Mokdad, Mariam Molokhia, Lorenzo Monasta, Masoud Moradi, Ghobad Moradi, Lidia Morawska, Seyyed Meysam Mousavi, Kamarul Imran Musa, Ghulam Mustafa, Mehdi Naderi, Mohsen Naghavi, Gurudatta Naik, Sanjeev Nair, Vinay Nangia, Jobert Richie Nansseu, Javad Nazari, Duduzile Edith Ndwandwe, Ruxandra Irina Negoi, Trang Huyen Nguyen, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Molly R. Nixon, Richard Ofori-Asenso, Felix Akpojene Ogbo, Andrew T. Olagunju, Tinuke O. Olagunju, Eyal Oren, Justin R. Ortiz, Mayowa O. Owolabi, Mahesh P. A., Smita Pakhale, Adrian Pana, Songhomitra Panda-Jonas, Eun-Kee Park, Hai Quang Pham, Maarten J. Postma, Hadi Pourjafar, Hossein Poustchi, Amir Radfar, Alireza Rafiei, Fakher Rahim, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Salman Rawaf, David Laith Rawaf, Lal Rawal, Robert C. Reiner Jr., Marissa Bettay Reitsma, Leonardo Roever, Luca Ronfani, Elias Merdassa Roro, Gholamreza Roshandel, Kristina E. Rudd, Yogesh Damodar Sabde, Siamak Sabour, Basema Saddik, Saeed Safari, Komal Saleem, Abdallah M. Samy, Milena M. Santric-Milicevic, Bruno Piassi Sao Jose, Benn Sartorius, Maheswar Satpathy, Miloje Savic, Monika Sawhney, Sadaf G. Sepanlou, Masood Ali Shaikh, Aziz Sheikh, Mika Shigematsu, Reza Shirkoohi, Si Si, Soraya Siabani, Virendra Singh, Jasvinder A. Singh, Michael Soljak, Ranjani Somayaji, Moslem Soofi, Ireneous N. Soyiri, Yonatal Mesfin Tefera, Mohamad-Hani Temsah, Berhe Etsay Tesfay, Jarnail Singh Thakur, Alemayehu Toma Toma, Miguel Tortajada-Girbés, Khanh Bao Tran, Bach Xuan Tran, Lorainne Tudor Car, Irfan Ullah, Marco Vacante, Pascual R. Valdez, Job F. M. Van Boven, Tommi Juhani Vasankari, Yousef Veisani, Francesco S. Violante, Gregory R. Wagner, Ronny Westerman, Charles D. A. Wolfe, Dawit Zewdu Wondafrash, Adam Belay Wondmieneh, Naohiro Yonemoto, Seok-Jun Yoon, Zoubida Zaidi, Mohammad Zamani, Heather J. Zar, Yunquan Zhang, Theo Vos, Gbd Chronic Respiratory Disease Collaborators

Research outputs 2014 to 2021

© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Previous attempts to characterise the burden of chronic respiratory diseases have focused only on specific disease conditions, such as chronic obstructive pulmonary disease (COPD) or asthma. In this study, we aimed to characterise the burden of chronic respiratory diseases globally, providing a comprehensive and up-to-date analysis on geographical and time trends from 1990 to 2017. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, we estimated the prevalence, morbidity, and mortality attributable …

The Effects Of Yam Gruel On Lowering Fasted Blood Glucose In T2dm Rats, Xinjun Lin, Zongting Luo, Shuqin Pang, Carol Chunfeng Wang, Li Ge, Yanling Dai, Jian Zhou, Fang Chen, Xuepei Hong, Jiahui Zhang

Research outputs 2014 to 2021

© 2020 Xinjun Lin et al., published by De Gruyter 2020. There is increasing evidence of the linkage between type 2 diabetes mellitus (T2DM) and gut microbiota. Based on our previous studies, we investigated the hypoglycemic mechanisms of yam gruel to provide a scientific basis for its popularization and application. Wistar rats were randomly divided into control and T2DM model groups. Rats in the model group were stimulated by a high-sugar/high-fat diet combined with an intraperitoneal injection of streptozotocin to induce T2DM. The T2DM rats were further subdivided randomly into three groups: (1) DM, (2) DM + yam gruel, and …

Mapping Of Diabetes Susceptibility Loci In A Domestic Cat Breed With An Unusually High Incidence Of Diabetes Mellitus, Lois Balmer, Caroline Ann O’Leary, Marilyn Menotti-Raymond, Victor David, Stephen O’Brien, Belinda Penglis, Sher Hendrickson, Mia Reeves-Johnson, Susan Gottlieb, Linda Fleeman, Dianne Vankan, Jacquie Rand, Grant Morahan

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Genetic variants that are associated with susceptibility to type 2 diabetes (T2D) are important for identification of individuals at risk and can provide insights into the molecular basis of disease. Analysis of T2D in domestic animals provides both the opportunity to improve veterinary management and breeding programs as well as to identify novel T2D risk genes. Australian-bred Burmese (ABB) cats have a 4-fold increased incidence of type 2 diabetes (T2D) compared to Burmese cats bred in the United States. This is likely attributable to a genetic founder effect. We investigated this …

Acute Physiological Responses To High-Intensity Resistance Circuit Training Vs. Traditional Strength Training In Soccer Players, Cristian Marín-Pagán, Anthony J. Blazevich, Linda H. Chung, Salvador Romero-Arenas, Tomás T. Freitas, Pedro E. Alcaraz

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The aim of this study was to evaluate and compare the cardiorespiratory and metabolic responses induced by high-intensity resistance circuit-based (HRC) and traditional strength (TS) training protocols. Ten amateur soccer players reported to the laboratory on four occasions: (1) protocol familiarization and load determination; (2) maximal oxygen consumption test; (3) and (4) resistance training protocols (HRC and TS), completed in a cross-over randomized order. In both protocols, the same structure was used (two blocks of 3 sets × 3 exercises, separated by a 5-min rest), with only the time between consecutive …

Supporting New Graduate Registered Nurse Transition For Safety: A Literature Review Update, Melanie Murray, Deborah Sundin, Vicki Cope

Research outputs 2014 to 2021

Background: Reports suggest higher incidence of medical errors occur during times of transition for new practitioners, in part due to general staff disruption in the health services and inexperience of those entering the workplace. NGRNs experience a range of challenges on transition to professional practice and their transition experience will impact their ability to provide high quality patient care.

Aim: The aim of this review was to critically appraise the contemporary literature concerning the transition of new graduate registered nurses (NGRNs) and their patient safety knowledge and practices.

Design: A scoping review of research literature.

Methods: The review used key …

The External Validity Of A Novel Contract-Relax Stretching Technique On Knee Flexor Range Of Motion, Anthony D. Kay, Joshua Dixon, Liam D. Bligh, Anthony J. Blazevich

Research outputs 2014 to 2021

Introduction: Compromised joint range of motion (ROM) can negatively affect the capacity to perform activities of daily living in clinical populations. Recently, similar improvements in dorsiflexion ROM were reported following dynamometry‐based contract‐relax (CR) stretching and modified CR stretching technique (stretch‐return‐contract [SRC]) where the contraction phase was performed “off stretch.” As neither the impact of SRC on other muscle groups nor the ecological validity of SRC performed in an applied environment has been tested, the acute effects of both techniques in dynamometry‐ (CR_dyna and SRC_dyna) and field‐based (CR_field and SRC_field) environments were compared with the …

Characterizing The Composition Of The Pediatric Gut Microbiome: A Systematic Review, Kane E. Deering, Amanda Devine, Therese A. O’Sullivan, Johnny Lo, Mary C. Boyce, Claus T. Christophersen

Research outputs 2014 to 2021

The consortium of trillions of microorganisms that live inside the human gut are integral to health. Little has been done to collate and characterize the microbiome of children. A systematic review was undertaken to address this gap (PROSPERO ID: CRD42018109599). MEDLINE and EMBASE were searched using the keywords: “healthy preadolescent children” and “gut microbiome” to 31 August 2018. Of the 815 journal articles, 42 met the inclusion criteria. The primary outcome was the relative abundance of bacteria at the phylum, family, and genus taxonomic ranks. α-diversity, short chain fatty acid concentrations, diet, 16S rRNA sequencing region, and geographical location were …

Liquid Biopsy In Ovarian Cancer Using Circulating Tumor Dna And Cells: Ready For Prime Time?, Du-Bois Asante, Leslie Calapre, Melanie Ziman, Tarek M. Meniawy, Elin S. Gray

Research outputs 2014 to 2021

Liquid biopsies hold the potential to inform cancer patient prognosis and to guide treatment decisions at the time when direct tumor biopsy may be impractical due to its invasive nature, inaccessibility and associated complications. Specifically, circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) have shown promising results as companion diagnostic biomarkers for screening, prognostication and/or patient surveillance in many cancer types. In ovarian cancer (OC), CTC and ctDNA analysis allow comprehensive molecular profiling of the primary, metastatic and recurrent tumors. These biomarkers also correlate with overall tumor burden and thus, they provide minimally-invasive means for patient monitoring during clinical …

Association Of Suboptimal Health Status With Intestinal Microbiota In Chinese Youths, Qi Sun, Xizhu Xu, Jie Zhang, Ming Sun, Qiuyue Tian, Qihuan Li, Weijie Cao, Xiaoyu Zhang, Hao Wang, Jiaonan Liu, Jinxia Zhang, Xiaoni Meng, Lijuan Wu, Manshu Song, Hongqi Liu, Wei Wang, Youxin Wang

Research outputs 2014 to 2021

Suboptimal health status (SHS), a physical state between health and disease, is a subclinical and reversible stage of chronic disease. Previous studies have shown alterations in the intestinal microbiota in patients with some chronic diseases. This study aimed to investigate the association between SHS and intestinal microbiota in a case-control study with 50 SHS individuals and 50 matched healthy controls. Intestinal microbiota was analysed by MiSeq 250PE. Alpha diversity of intestinal microbiota in SHS individuals was higher compared with that of healthy controls (Simpson index, W = 2238, P = .048). Beta diversity was different between SHS and healthy controls …

Corrections To: The Effect Of Nordic Hamstring Exercise Intervention Volume On Eccentric Strength And Muscle Architecture Adaptations: A Systematic Journal Article And Meta-Analyses, Matthew Cuthbert, Nicholas Ripley, John J. Mcmahon, Martin Evans, G. Gregory Haff, Paul Comfort

Research outputs 2014 to 2021

No abstract provided.

Exercise Twice-A-Day Potentiates Markers Of Mitochondrial Biogenesis In Men, Victor Amorim Andrade-Souza, Thaysa Ghiarone, Andre Sansonio, Kleiton Augusto Santos Silva, Fabiano Tomazini, Lucyana Arcoverde, Jackson Fyfe, Enrico Perri, Nicholas Saner, Jujiao Kuang, Romulo Bertuzzi, Carol Gois Leandro, David John Bishop, Adriano Eduardo Lima‐Silva

Research outputs 2014 to 2021

Endurance exercise begun with reduced muscle glycogen stores seems to potentiate skeletal muscle protein abundance and gene expression. However, it is unknown whether this greater signaling responses is due to performing two exercise sessions in close proximity-as a first exercise session is necessary to reduce the muscle glycogen stores. In the present study, we manipulated the recovery duration between a first muscle glycogen-depleting exercise and a second exercise session, such that the second exercise session started with reduced muscle glycogen in both approaches but was performed either 2 or 15 hours after the first exercise session (so-called "twice-a-day" and "once-daily" …

Association Of Single Nucleotide Polymorphisms With Dyslipidemia In Antiretroviral Exposed Hiv Patients In A Ghanaian Population: A Case-Control Study, Christian Obirikorang, Emmanuel Acheampong, Lawrence Quaye, Joseph Yorke, Ernestine Kubi Amos-Abanyie, Priscilla Abena Akyaw, Enoch Odame Anto, Simon Bannison Bani, Evans Adu Asamoah, Emmanuella Nsenbah Batu

Research outputs 2014 to 2021

Dyslipidemia is a potential complication of long-term usage of antiretroviral therapy (ART) and also known to be associated with genetic factors. The host genetic variants associated with dyslipidemia in HIV patients on ART in Ghana have not been fully explored. The study constituted a total of 289 HIV-infected patients on stable ART for at least a year. Fasting blood was collected into EDTA tube for lipids measurement. Lipid profiles were used to define dyslipidemia based on the NCEP-ATP III criteria. HIV-infected subjects were categorized into two groups; those with dyslipidemia (cases) (n = 90; 31.1%) and without dyslipidemia (controls)(n = …

Predictors Of Ceasing Or Reducing Statin Medication Following A Large Increase In The Consumer Copayment For Medications: A Retrospective Observational Study, Karla Seamon, Frank Sanfilippo, Max Bulsara, Libby Roughead, Anna Kemp-Casey, Caroline Bulsara, Gerald F. Watts, David Preen

Research outputs 2014 to 2021

OBJECTIVES:

Previous Australian research has shown that following the 21% increase in patient copayments for medications on the Pharmaceutical Benefits Scheme (PBS) in 2005, the use of lipid-lowering therapy declined by 5%. This study aimed to determine the demographic and clinical characteristics of individuals who continued, reduced or ceased their use of statin medication in 2005.

STUDY TYPE:

Retrospective observational study using routinely collected administrative data.

METHOD:

We used pharmaceutical claims, hospital separations and mortality records from 2000 to 2005 for the Western Australian population. The cohort comprised stable users of statin medication in 2004. Based on changes in statin …

Bilingualism Is Associated With A Delayed Onset Of Dementia But Not With A Lower Risk Of Developing It: A Systematic Review With Meta-Analyses, Stefano Brini, Hamid R. Sohrabi, Jeffrey J. Hebert, Mitchell R.L. Forrest, Matti Laine, Heikki Hämäläinen, Mira Karrasch, Jeremiah Peiffer, Ralph Martins, Timothy J. Fairchild

Research outputs 2014 to 2021

Some studies have linked bilingualism with a later onset of dementia, Alzheimer’s disease (AD), and mild cognitive impairment (MCI). Not all studies have observed such relationships, however. Differences in study outcomes may be due to methodological limitations and the presence of confounding factors within studies such as immigration status and level of education. We conducted the first systematic review with meta-analysis combining cross-sectional studies to explore if bilingualism might delay symptom onset and diagnosis of dementia, AD, and MCI. Primary outcomes included the age of symptom onset, the age at diagnosis of MCI or dementia, and the risk of developing …

Recent High School Graduates Support Mandatory Cardiopulmonary Resuscitation Education In Australian High Schools, Tim Rankin, Lisa Holmes, Leanne Vance, Tom Crehan, Brennen Mills

Research outputs 2014 to 2021

Objective:

To evaluate recent high school graduates' opinions on mandatory cardiopulmonary resuscitation (CPR) training in the high school curriculum as a solution to improving bystander CPR rates.

Methods:

Participants completed questionnaires assessing their CPR training history during their high school education, their willingness to learn CPR during their high school years and their opinion on making CPR training mandatory for high school curricula.

Results:

Of the 178 participants in this study, 60% had undertaken CPR training during their high school education. Of those who had not undertaken CPR training, 75% reported that they would have been willing …

The Gut Microbiota, Environmental Factors, And Links To The Development Of Food Allergy, Khui Hung Lee, Yong Song, Weidong Wu, Kan Yu, Guicheng Zhang

Research outputs 2014 to 2021

Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tolerogenic immune function. High-throughput sequencing technology has facilitated in-depth studies of the gut microbiota as well as bacterial-derived metabolites. Although the role of the microbiota in allergies is now widely studied, its importance for food allergy was only recently noted. Studies in human cohorts have shown that there is an association of dysbiosis and pathogenesis of food …

Elecsys Csf Biomarker Immunoassays Demonstrate Concordance With Amyloid-Pet Imaging, James A. Doecke, Larry Ward, Samantha C. Burnham, Victor L. Villemagne, Qiao-Xin Li, Steven Collins, Christopher J. Fowler, Ekaterina Manuilova, Monika Widmann, Stephanie R. Rainey-Smith, Ralph N. Martins, Colin L. Masters, Aibl Research Group

Research outputs 2014 to 2021

Background: β-amyloid (Aβ) positron emission tomography (PET) imaging is currently the only Food and Drug Administration-approved method to support clinical diagnosis of Alzheimer's disease (AD). However, numerous research studies support the use of cerebrospinal fluid (CSF) biomarkers, as a cost-efficient, quick and equally valid method to define AD pathology. Methods: Using automated Elecsys® assays (Roche Diagnostics) for Aβ (1-42) (Aβ42), Aβ (1-40) (Aβ40), total tau (tTau) and phosphorylated tau (181P) (pTau), we examined CSF samples from 202 participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing cohort, to demonstrate the concordance with pathological AD via PET imaging. …

Anterior Cruciate Ligament Injuries In Australian Football: Should Women And Girls Be Playing? You're Asking The Wrong Question, Aaron Fox, Jason Bonacci, Samantha Hoffmann, Sophia Nimphius, Natalie Saunders

Research outputs 2014 to 2021

Anterior cruciate ligament (ACL) injuries have been a rising concern in the early years of the women's Australian Football League (AFLW), eliciting headlines of a â € knee crisis' surrounding the league. There has been a focus on female biology as the primary factor driving the high rate of ACL injuries in the AFLW. Emphasising Australian football (AF) as being dangerous predominantly due to female biology may be misrepresenting a root cause of the ACL injury problem, perpetuating gender stereotypes that can restrict physical development and participation of women and girls in the sport. We propose that an approach addressing …

First Age- And Gender-Matched Case-Control Study In Australia Examining The Possible Association Between Toxoplasma Gondii Infection And Type 2 Diabetes Mellitus: The Busselton Health Study, Aus Molan, Kazunori Nosaka, Michael Hunter, Jinxia Zhang, Xiaoni Meng, Manshu Song, Wei Wang

Research outputs 2014 to 2021

An emerging field of research is starting to examine the association of infectious pathogens with type 2 diabetes mellitus (T2DM). An understudied parasite of interest is Toxoplasma gondii. Globally, very few studies have been conducted to investigate this association. Additionally, very little data exists on the prevalence of T. gondii in the general Australian population. Our group sought to determine the prevalence, association, and risk factors between T. gondii infection and T2DM from a representative Australian human population. Through a cross-sectional, age-A nd gender-matched case-control study, 150 subjects with T2DM together with 150 control subjects from the Busselton Health Study …

A Comparative Study Of Extracellular Vesicle-Associated And Cell-Free Dna And Rna For Hpv Detection In Oropharyngeal Squamous Cell Carcinoma, Bella Nguyen, Katie Meehan, Michelle R. Pereira, Bob Mirzai, Si Hong Lim, Connull Leslie, Michael Clark, Chady Sader, Peter Friedland, Andrew Lindsay, Colin Tang, Michael Milward, Elin S. Gray, Annette M. Lim

Research outputs 2014 to 2021

Purpose: This study compares the detection sensitivity of two separate liquid biopsy sources, cell-free (cf) DNA/RNA and extracellular vesicle (EV)-associated DNA/RNA (EV-DNA/RNA), to identify circulating Human Papilloma Virus (HPV) DNA/RNA in plasma obtained from patients with oropharyngeal squamous cell carcinoma (OPCSCC). We also report on the longitudinal changes observed in HPV-DNA levels in response to treatment. Experimental design: A prospective study was conducted that included 22 patients with locally advanced disease and six patients with metastatic OPCSCC. Twenty-three patients had HPV-related OPCSCC defined by p16 immunohistochemistry. Levels of circulating HPV-DNA and HPV-RNA from plasma-derived cf-DNA/RNA and EV-DNA/RNA were quantified using …

South West Food Community: How Government And Community Initiatives Are Supporting Systemic Change Towards Enhanced Food Security, Stephanie Louise Godrich, Melissa Stoneham, Melinda Edmunds, Amanda Devine

Research outputs 2014 to 2021

Objective: Food security refers to adequate physical, social and economic access to food and is regarded as a complex, ‘wicked’ issue. This research aimed to understand the perspectives of initiative leaders (stakeholders), regarding their project relating to food security and its possession of characteristics associated with system change to enhance food security. Methods: Stakeholders (n=51) participated in semi-structured interviews that evaluated initiatives (n=52) against 36 desirable characteristics for system change. Transcripts were analysed using QSR NVivo and Wicked Lab’s Tool for Systemic Change. Results: Community-based initiatives often harnessed the passion of local communities to enhance food security through awareness-raising activities …

Summary Of Tobacco Use Among Aboriginal And Torres Strait Islander Peoples, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

The Summary of tobacco use among Aboriginal and Torres Strait Islander peoples is a plain language publication that provides summarised and updated information from the Review of tobacco use among Aboriginal and Torres Strait Islander peoples(2020). It provides key information about tobacco use among Aboriginal and Torres Strait Islander peoples in a style that is easy to engage with and is particularly useful for health workers and those studying in the field as a quick source of general information about:

• the context of tobacco use and how common tobacco use is
• how smoking affects health
• the burden of disease …

Summary Of Respiratory Diseases Among Aboriginal And Torres Strait Islander Children, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

The Summary of respiratory diseases among Aboriginal and Torres Strait Islander children is a plain language publication that provides summarised and updated information from the Review of respiratory diseases among Aboriginal and Torres Strait Islander children published by the Australian Indigenous HealthInfoNet in 2018. The Summaryis useful for health workers and those studying in the field as a quick source of information about respiratory diseases among Aboriginal and Torres Strait Islander children. It focuses on:

• factors contributing to Aboriginal and Torres Strait Islander children's respiratory diseases
• how common acute and chronic respiratory diseases are
• prevention and management of …