Medicine and Health Sciences Commons^™

Comparing An Ehealth Program (My Hip Journey) With Standard Care For Total Hip Arthroplasty: Randomized Controlled Trial, Rosemary Saunders, Karla Seaman, Laura Emery, Max Bulsara, Catherine Ashford, Judith Mcdowall, Karen Gullick, Beverley Ewens, Trudy Sullivan, Charlotte Foskett, Lisa Whitehead

Research outputs 2014 to 2021

Background: The role of eHealth programs to support patients through surgical pathways, including total hip arthroplasty (THA), is rapidly growing and offers the potential to improve patient engagement, self-care, and outcomes. Objective: The aim of this study is to compare the effects of an eHealth program (intervention) versus standard care for pre- and postoperative education on patient outcomes for primary THA. Methods: A prospective parallel randomized controlled trial with two arms (standard care and standard care plus access to the eHealth education program) was conducted. Participants included those who underwent THA. Outcome measures were collected preadmission, at 6 weeks, and …

A Geospatiotemporal And Causal Inference Epidemiological Exploration Of Substance And Cannabinoid Exposure As Drivers Of Rising Us Pediatric Cancer Rates, Albert S. Reece, Gary K. Hulse

Research outputs 2014 to 2021

Background: Age-adjusted US total pediatric cancer incidence rates (TPCIR) rose 49% 1975–2015 for unknown reasons. Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majority of pediatric cancer types. We investigated whether cannabis use was related spatiotemporally and causally to TPCIR. Methods: State-based age-adjusted TPCIR data was taken from the CDC Surveillance, Epidemiology and End Results cancer database 2003–2017. Drug exposure was taken from the nationally-representative National Survey of Drug Use and Health, response rate 74.1%. Drugs included were: tobacco, alcohol, cannabis, opioid analgesics and cocaine. This was supplemented by cannabinoid concentration data from the …

Metabolomics And Lipidomics: Expanding The Molecular Landscape Of Exercise Biology, Mehdi R. Belhaj, Nathan G. Lawler, Nolan J. Hoffman

Research outputs 2014 to 2021

Dynamic changes in circulating and tissue metabolites and lipids occur in response to exercise-induced cellular and whole-body energy demands to maintain metabolic homeostasis. The metabolome and lipidome in a given biological system provides a molecular snapshot of these rapid and complex metabolic perturbations. The application of metabolomics and lipidomics to map the metabolic responses to an acute bout of aerobic/endurance or resistance exercise has dramatically expanded over the past decade thanks to major analytical advancements, with most exercise-related studies to date focused on analyzing human biofluids and tissues. Experimental and analytical con-siderations, as well as complementary studies using animal model …

Exploring The Usability Of The Com-B Model And Theoretical Domains Framework (Tdf) To Define The Helpers Of And Hindrances To Evidence-Based Practice In Midwifery, Annemarie De Leo, Sara J. Bayes, Dianne Bloxsome, Janice Butt

Research outputs 2014 to 2021

Background Despite the advancement of scientific research in the field of maternity care, midwives face challenges translating latest evidence into evidence-based practice (EBP) and express reticence towards leading practice change in clinical areas. This study aimed to explore midwifery leaders’ views on what factors help or hinder midwives’ efforts to translate latest evidence into everyday practice and consider them in relation to both the Capability, Opportunity, Motivation and Behaviour (COM-B) model and Theoretical Domains Framework (TDF). Methods This qualitative study formed part of a larger action research (AR) project that was designed to improve midwives’ EBP implementation capability. Data were …

Hospital Staff, Volunteers’ And Patients’ Perceptions Of Barriers And Facilitators To Communication Following Stroke In An Acute And A Rehabilitation Private Hospital Ward: A Qualitative Description Study, Sarah D'Souza, Erin Godecke, Natalie Ciccone, Deborah J. Hersh, Heidi Janssen, Elizabeth Armstrong

Research outputs 2014 to 2021

Objectives

To explore barriers and facilitators to patient communication in an acute and rehabilitation ward setting from the perspectives of hospital staff, volunteers and patients following stroke.

Design

A qualitative descriptive study as part of a larger study which aimed to develop and test a Communication Enhanced Environment model in an acute and a rehabilitation ward.

Setting

A metropolitan Australian private hospital.

Participants

Focus groups with acute and rehabilitation doctors, nurses, allied health staff and volunteers (n=51), and interviews with patients following stroke (n=7), including three with aphasia, were conducted.

Results

The key themes related to barriers and facilitators to …

Meta-Analysis Of Genome-Wide Dna Methylation Identifies Shared Associations Across Neurodegenerative Disorders, Marta F. Nabais, Simon M. Laws, Tian Lin, Costanza L. Vallerga, Nicola J. Armstrong, Ian P. Blair, John B. Kwok, Karen A. Mather, George D. Mellick, Perminder S. Sachdev, Leanne Wallace, Anjali K. Henders, Ramona A. J. Zwamborn, Paul J. Hop, Katie Lunnon, Ehsan Pishva, Janou A. Y. Roubroeks, Hilkka Soininen, Magda Tsolaki, Patrizia Mecocci, Simon Lovestone, Iwona Kłoszewska, Bruno Vellas, Sarah Furlong, Fleur C. Garton, Robert D. Henderson, Susan Mathers, Pamela A. Mccombe, Merrilee Needham, Shyuan T. Ngo, Garth Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Tim J. Anderson, Steven R. Bentley, John Dalrymple-Alford, Javed Fowder, Jacob Gratten, Glenda Halliday, Ian B. Hickie, Martin Kennedy, Simon J. G. Lewis, Grant W. Montgomery, John Pearson, Toni L. Pitcher, Peter Silburn, Futao Zhang, Peter M. Visscher, Jian Yang, Anna J. Stevenson, Robert F. Hillary, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary, Ashley R. Jones, Aleksey Shatunov, Alfredo Iacoangeli, Wouter Van Rheenen, Leonard H. Van Den Berg, Pamela J. Shaw, Cristopher E. Shaw, Karen E. Morrison, Ammar Al-Chalabi, Jan H. Veldink, Eilis Hannon, Jonathan Mill, Naomi R. Wray, Allan F. Mcrae, The Alzheimer's Disease Neuroimaging Initiative, The Australian Imaging Biomarkers And Lifestyle Study

Research outputs 2014 to 2021

Background: People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to explore this overlap and heterogeneity as it is determined by the combined effects of genetic variation and the environment. In this study, we aim to identify shared blood DNAm differences between controls and people with Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease. Results: We use a mixed-linear model method (MOMENT) that accounts for the effect of (un)known confounders, to test for the association of each DNAm site with each …

Core Alzheimer’S Disease Cerebrospinal Fluid Biomarker Assays Are Not Affected By Aspiration Or Gravity Drip Extraction Methods, James D. Doecke, Cindy Francois, Christopher J. Fowler, Erik Stoops, Pierrick Bourgeat, Stephanie R. Rainey-Smith, Qiao-Xin Li, Colin L. Masters, Ralph N. Martins, Victor L. Villemagne, Steven J. Collins, Hugo Marcel Vanderstichele

Research outputs 2014 to 2021

Background: CSF biomarkers are well-established for routine clinical use, yet a paucity of comparative assessment exists regarding CSF extraction methods during lumbar puncture. Here, we compare in detail biomarker profiles in CSF extracted using either gravity drip or aspiration. Methods: Biomarkers for β-amyloidopathy (Aβ1–42, Aβ1–40), tauopathy (total tau), or synapse pathology (BACE1, Neurogranin Trunc-p75, α-synuclein) were assessed between gravity or aspiration extraction methods in a sub-population of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study (cognitively normal, N = 36; mild cognitive impairment, N = 8; Alzheimer’s disease, N = 6). Results: High biomarker concordance between extraction methods was seen …

Circulating Tumor Dna Reflects Uveal Melanoma Responses To Protein Kinase C Inhibition, John J. Park, Russell J. Diefenbach, Natalie Byrne, Georgina V. Long, Richard A. Scolyer, Elin S. Gray, Matteo S. Carlino, Helen Rizos

Research outputs 2014 to 2021

The prognosis for patients with UM is poor, and recent clinical trials have failed to prolong overall survival (OS) of these patients. Over 95% of UM harbor activating driver mutations, and this allows for the investigation of ctDNA. In this study, we investigated the value of ctDNA for adaptive clinical trial design in metastatic UM. Longitudinal plasma samples were analyzed for ctDNA in 17 metastatic UM patients treated with PKCi-based therapy in a phase 1 clinical trial setting. Plasma ctDNA was assessed using digital droplet PCR (ddPCR) and a custom melanoma gene panel for targeted next generation sequencing (NGS). Baseline …

Association Of Genetic Variances In Adrb1 And Ppargc1a With Two-Kilometre Running Time-Trial Performance In Australian Football League Players: A Preliminary Study, Ysabel Jacob, Ryan S. Anderton, Jodie L. Cochrane Wilkie, Brent Rogalski, Simon M. Laws, Anthony Jones, Tania Spiteri, Nicolas H. Hart

Research outputs 2014 to 2021

Abstract: Genetic variants in the angiotensin-converting enzyme (ACE) (rs4343), alpha-actinin-3 (ACTN3) (rs1815739), adrenoceptor-beta-1 (ADRB1) (rs1801253), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) (rs8192678) genes have previously been associated with elite athletic performance. This study assessed the influence of polymorphisms in these candidate genes towards endurance test performance in 46 players from a single Australian Football League (AFL) team. Each player provided saliva buccal swab samples for DNA analysis and genotyping and were required to perform two independent two-kilometre running time-trials, six weeks apart. Linear mixed models were created to account for repeated measures over time and to determine whether …

Using Exercise And Nutrition To Alter Fat And Lean Mass In Men With Prostate Cancer Receiving Androgen Deprivation Therapy: A Narrative Review, Rebekah L. Wilson, Dennis R. Taaffe, Robert U. Newton, Nicolas H. Hart, Philippa Lyons-Wall, Daniel A. Galvao

Research outputs 2014 to 2021

Fat mass (FM) gain and lean mass (LM) loss are common side effects for patients with prostate cancer receiving androgen deprivation therapy (ADT). Excess FM has been associated with an increased risk of developing obesity-related comorbidities, exacerbating prostate cancer progression, and all-cause and cancer-specific mortality. LM is the predominant contributor to resting metabolic rate, with any loss impacting long-term weight management as well as physical function. Therefore, reducing FM and preserving LM may improve patient-reported outcomes, risk of disease progression, and ameliorate comorbidity development. In ADT-treated patients, exercise and nutrition programs can lead to improvements in quality of life and …

Flavonoid Intake And Incident Dementia In The Danish Diet, Cancer, And Health Cohort, Catherine P. Bondonno, Nicola P. Bondonno, Frederik Dalgaard, Kevin Murray, Samantha L. Gardener, Ralph N. Martins, Stephanie R. Rainey-Smith, Aedín Cassidy, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson

Research outputs 2014 to 2021

No abstract provided.

Prevalence Of Distress, Its Associated Factors And Referral To Support Services In People With Cancer, Deborah Kirk, Istvan (Ishti) Kabdebo, Lisa Whitehead

Research outputs 2014 to 2021

Aims and objectives:

To (i) characterise prevalence of distress amongst people diagnosed with cancer, (ii) determine factors associated with increasing distress, (iii) describe reported problems for those with clinically significant distress and (iv) investigate the factors associated with referral to support services.

Background:

International studies report a high prevalence of clinically significant distress in people with cancer. Australian studies are notably lacking. Additionally, clinicians still do not fully understand the factors associated with cancer-related distress.

Design:

Period prevalence study.

Methods:

Distress screening data were analysed for 1,071 people accessing the Cancer Council Western Australia information and support line between 01/01/2016–31/12/2018. …

Predictors Of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis, The Rehabilitation And Recovery Of People With Aphasia After Stroke (Release) Collaborators

Research outputs 2014 to 2021

Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all …

Exercise Medicine In The Management Of Pancreatic Cancer: A Systematic Review, Hao Luo, Daniel A. Galvão, Robert U. Newton, Pedro Lopez Da Cruz, Colin Tang, Ciaran M. Fairman, Nigel Spry, Dennis R. Taaffe

Research outputs 2014 to 2021

The aim of this study was to examine the health-related effects of exercise in patients with pancreatic cancer (PanCa) through a systematic review of current evidence. Studies were obtained through searching PubMed, Web of Science, PsycINFO, Embase, CINAHL Plus, and Cochrane Library databases with additional hand searches. All intervention-based studies were included if it involved (1) adult patients with PanCa, (2) exercise training, and (3) findings in quality of life, cancer-related fatigue, psychological distress, and physical function. The review protocol was registered in PROSPERO: CRD42020154684. Seven trials described in 9 publications were included consisting of 201 patients with early-stage and …

Association Of Β-Amyloid Level, Clinical Progression And Longitudinal Cognitive Change In Normal Older Individuals, Laura M. Van Der Krall, Thanh Truong, Samantha C. Burnham, Vincent Doré, Rachel S. Mulligan, Svetlana Bozinovski, Fiona Lamb, Pierrick Bourgeat, Jurgen Fripp, Stephanie Schultz, Yen Y. Lim, Simon M. Laws, David Ames, Christopher Fowler, Stephanie R. Rainey-Smith, Ralph N. Martins, Olivier Salvado, Joanne Robertson, Paul Maruff, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe

Research outputs 2014 to 2021

Objective To determine the effect of β-amyloid (Aβ) level on progression risk to mild cognitive impairment (MCI) or dementia and longitudinal cognitive change in cognitively normal (CN) older individuals. Methods All CN from the Australian Imaging Biomarkers and Lifestyle study with Aβ PET and ≥ 3 years follow-up were included (n = 534; age 72 ± 6 years; 27% Aβ positive; follow-up 5.3 ± 1.7 years). Aβ level was divided using the standardized 0–100 Centiloid scale: < 15 CL negative, 15–25 CL uncertain, 26–50 CL moderate, 51–100 CL high, > 100 CL very high, noting > 25 CL approximates a positive scan. Cox proportional hazards analysis and linear mixed effect models were used to assess …

Are We Heading For Disaster? The Problem With Resilience In Disaster Management And Recovery, Zachary Horn

Research outputs 2014 to 2021

Resilience is often construed as armour that protects individuals from stressors and harm, or a trait that allows people to ‘bounce back’ despite adversities and stressors. Although not fundamentally incorrect, these notions do not capture the true purpose, scope or power of resilience, particularly in the disaster context.

The Impact Of Nurse Staffing Methodologies On Nurse And Patient Outcomes: A Systematic Review, Diane E. Twigg, Lisa Whitehead, Gemma Doleman, Sonia El-Zaemey

Research outputs 2014 to 2021

Aim

Aim of this study is to systematically review and synthesize available evidence to identify the association between nurse staffing methodologies and nurse and patient outcomes.

Design

Systematic review and narrative synthesis.

Data sources

A search of MEDLINE (EBSCO), CINAHL (EBSCO) and Web of Science was conducted for studies published in English between January 2000 and January 2020.

Review methods

The reporting of this review and narrative synthesis was guided by the preferred reporting items for systematic and meta-analysis guidelines (PRISMA) statement and data synthesis guided by the Synthesis Without Meta-analysis (SWiM) guideline. The quality of each article was assessed …

Longitudinal Trajectories In Cortical Thickness And Volume Atrophy: Superior Cognitive Performance Does Not Protect Against Brain Atrophy In Older Adults, Samantha Gardener, Michael Weinborn, Hamid R. Sohrabi, James Doecke, Pierrick Bourgeat, Stephanie R. Rainey-Smith, Kai-Kai Shen, Jurgen Fripp, Kevin Taddei, Paul Maruff, Olivier Salvado, Greg Savage, David Ames, Colin L. Masters, Christopher C. Rowe, Ralph Martins, Aibl Research Group

Research outputs 2014 to 2021

Background:

Previous research has identified a small subgroup of older adults that maintain a high level of cognitive functioning well into advanced age. Investigation of those with superior cognitive performance (SCP) for their age is important, as age-related decline has previously been thought to be inevitable.

Objective:

Preservation of cortical thickness and volume was evaluated in 76 older adults with SCP and 100 typical older adults (TOAs) assessed up to five times over six years.

Methods:

Regions of interest (ROIs) found to have been associated with super-aging status (a construct similar to SCP status) in previous literature were investigated, followed …

Genome Wide Association Study Of Response To Interval And Continuous Exercise Training: The Predict-Hiit Study, Camilla J. Williams, Zhixiu Li, Nicholas Harvey, Rodney A. Lea, Brendon J. Gurd, Jacob T. Bonafiglia, Ioannis Papadimitriou, Macsue Jacques, Ilaria Croci, Dorthe Stensvold, Ulrik Wisloff, Jenna L. Taylor, Trishan Gajanand, Emily R. Cox, Joyce S. Ramos, Robert G. Fassett, Jonathan P. Little, Monique E. Francois, Christopher M. Hearon Jr, Satyam Sarma, Sylvan L. J. E. Janssen, Emeline M. Van Craenenbroeck, Paul Beckers, Véronique A. Cornelissen, Erin J. Howden, Shelley E. Keating, Xu Yan, David J. Bishop, Anja Bye, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Matthew A. Brown, Luciana Torquati, Nir Eynon, Jeff S. Coombes

Research outputs 2014 to 2021

Background: Low cardiorespiratory fitness (V̇O2peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O2peak, there is considerable inter-individual variability in the V̇O2peak response to the same dose of exercise. Understanding how genetic factors contribute to V̇O2peak training response may improve personalisation of exercise programs. The aim of this study was to identify genetic variants that are associated with the magnitude of V̇O2peak response following exercise training. Methods: Participant change in objectively measured V̇O2peak from 18 different interventions was obtained from a multi-centre study (Predict-HIIT). A genome-wide association …

Effects Of Variations In Resistance Training Frequency On Strength Development In Well-Trained Populations And Implications For In-Season Athlete Training: A Systematic Review And Meta-Analysis, Matthew Cuthbert, G. Gregory Haff, Shawn M. Arent, Nicholas Ripley, John J. Mcmahon, Martin Evans, Paul Comfort

Research outputs 2014 to 2021

Background: In-season competition and tournaments for team sports can be both long and congested, with some sports competing up to three times per week. During these periods of time, athletes need to prepare technically, tactically and physically for the next fixture and the short duration between fixtures means that, in some cases, physical preparation ceases, or training focus moves to recovery as opposed to progressing adaptations. Objective: The aim of this review was to investigate the effect of training frequency on muscular strength to determine if a potential method to accommodate in-season resistance training, during busy training schedules, could be …

Prostate Cancer Survivorship Care: If Not Now, When?, Jeffrey Dunn, Peter Heathcote, Suzanne K. Chambers

Research outputs 2014 to 2021

Prostate cancer is the most common cancer diagnosed in Australian men, excluding non-melanoma skin cancer, and it is estimated that there are over 220 000 Australian men living with a diagnosis of prostate cancer [1]. Survival for men with prostate cancer is excellent in countries that have accessible screening and treatment services, and in Australia 5-year relative survival is over 95% [1]. High incidence, coupled with improving long-term survival, leads to a correspondingly high prevalence rate and high community disease burden. Many men with prostate cancer experience long-term decrements in their mental and physical quality of life, overall they have …

Resistance Training Load Effects On Muscle Hypertrophy And Strength Gain: Systematic Review And Network Meta-Analysis, Pedro Lopez, Régis Radaelli, Dennis R. Taaffe, Robert U. Newton, Daniel A. Galvão, Gabriel S. Trajano, Juliana L. Teodoro, William J. Kraemer, Keijo Häkkinen, Ronei S. Pinto

Research outputs 2014 to 2021

Purpose This study aimed to analyze the effect of resistance training (RT) performed until volitional failure with low, moderate, and high loads on muscle hypertrophy and muscle strength in healthy adults and to assess the possible participant-, design-, and training-related covariates that may affect the adaptations. Methods Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, MEDLINE, CINAHL, EMBASE, SPORTDiscus, and Web of Science databases were searched. Including only studies that performed sets to volitional failure, the effects of low- ( > 15 repetitions maximum (RM)), moderate- (9-15 RM), and high-load ( ≤ 8 RM) RTs were examined in healthy …

A Population-Specific Major Allele Reference Genome From The United Arab Emirates Population, Gihan Daw Elbait, Andreas Henschel, Guan K. Tay, Habiba S. Al Safar

Research outputs 2014 to 2021

The ethnic composition of the population of a country contributes to the uniqueness of each national DNA sequencing project and, ideally, individual reference genomes are required to reduce the confounding nature of ethnic bias. This work represents a representative Whole Genome Sequencing effort of an understudied population. Specifically, high coverage consensus sequences from 120 whole genomes and 33 whole exomes were used to construct the first ever population specific major allele reference genome for the United Arab Emirates (UAE). When this was applied and compared to the archetype hg19 reference, assembly of local Emirati genomes was reduced by ∼19% (i.e., …

The Influence Of Sunlight Exposure And Sun Protecting Behaviours On Allergic Outcomes In Early Childhood, Kristina Rueter, Anderson P. Jones, Aris Siafarikas, Paola Chivers, Susan L. Prescott, Debra J. Palmer

Research outputs 2014 to 2021

The dramatic rise in allergic disease has occurred in tandem with recent environmental changes and increasing indoor lifestyle culture. While multifactorial, one consistent allergy risk factor has been reduced sunlight exposure. However, vitamin D supplementation studies have been disappointing in preventing allergy, raising possible independent effects of ultraviolet (UV) light exposure. The aim of this study was to examine whether UV light exposure influences the development of allergic disease in early childhood. Direct sunlight exposure (290–380 nm) in early infancy was measured via UV dosimeters. Outdoor exposure, sun protective behaviours, and allergy outcomes were assessed over the first 2.5 years …

Covid-19 Disease Severity And Death In Relation To Vitamin D Status Among Sars-Cov-2-Positive Uae Residents, Habiba Alsafar, William B. Grant, Rafiq Hijazi, Maimunah Uddin, Nawal Alkaabi, Guan Tay, Bassam Mahboub, Fatme Al Anouti

Research outputs 2014 to 2021

Insufficient blood levels of the neurohormone vitamin D are associated with increased risk of COVID-19 severity and mortality. Despite the global rollout of vaccinations and promising preliminary results, the focus remains on additional preventive measures to manage COVID-19. Results conflict on vitamin D’s plausible role in preventing and treating COVID-19. We examined the relation between vitamin D status and COVID-19 severity and mortality among the multiethnic population of the United Arab Emirates. Our observational study used data for 522 participants who tested positive for SARS-CoV-2 at one of the main hospitals in Abu Dhabi and Dubai. Only 464 of those …

Fathers’ Experiences Of Feeding Their Extremely Preterm Infants In Family-Centred Neonatal Intensive Care: A Qualitative Study, Evalotte Mörelius, Sofia Brogren, Sandra Andersson, Siw Alehagen

Research outputs 2014 to 2021

Background:

Extremely preterm infants need advanced intensive care for survival and are usually not discharged before they reach the time of expected birth. In a family-centred neonatal intensive care unit both parents are involved at all levels of care including the feeding process. However, studies focusing on fathers in this situation are scarce. The purpose of this study was to explore the experiences of feeding extremely preterm infants in a neonatal intensive care unit from fathers’ perspectives.

Methods:

The study adopts a qualitative inductive method, reported according to the COREQ checklist. Seven fathers of extremely preterm infants (gestational age 24–27 …

The Effectiveness Of Nurse-Led Interventions To Prevent Childhood And Adolescent Overweight And Obesity: A Systematic Review Of Randomised Trials, Lisa Whitehead, Istvan (Ishti) Kabdebo, Melissa Dunham, Robyn Quinn, Jennifer Hummelshoj, Cobie George, Elizabeth Denney-Wilson

Research outputs 2014 to 2021

Background:

Obesity among children and adolescents continues to rise worldwide. Despite the efforts of the healthcare workforce, limited high-quality evidence has been put forward demonstrating effective childhood obesity interventions. The role of nurses as primary actors in childhood obesity prevention has also been underresearched given the size of the workforce and their growing involvement in chronic disease prevention.

Aim:

To examine the effectiveness of nurse-led interventions to prevent childhood and adolescent overweight and obesity.

Design:

A systematic review of randomised trials.

Data sources:

Medline, CINAHL, EMBASE, Cochrane (CENTRAL), ProQuest Central and SCOPUS were searched from inception to March 2020.

Review …

Feasibility And Efficacy Of A Multicomponent Exercise Medicine Programme In Patients With Pancreatic Cancer Undergoing Neoadjuvant Therapy (The Expan Trial): Study Protocol Of A Dual-Centre, Two-Armed Phase I Randomised Controlled Trial, Hao Luo, Daniel A. Galvao, Robert U. Newton, Colin Tang, Andrew Dean, Kevin Jasas, Mikael Johansson, Ian Yusoff, Nigel Spry, Dennis R. Taaffe

Research outputs 2014 to 2021

Introduction Exercise is emerging as a therapy in oncology for its physical and psychosocial benefits and potential effects on chemotherapy tolerability and efficacy. However, evidence from randomised controlled trials (RCTs) supporting exercise in patients with borderline resectable or locally advanced pancreatic cancer (PanCa) undergoing neoadjuvant therapy (NAT) are lacking. Methods and analysis The EXPAN trial is a dual-centre, two-armed, phase I RCT. Forty patients with borderline resectable or locally advanced PanCa undergoing NAT will be randomised equally to an exercise intervention group (individualised exercise+standard NAT) or a usual care control group (standard NAT). The exercise intervention will be supervised and …

Revealing Meaning From Story: The Application Of Narrative Inquiry To Explore The Factors That Influence Decision Making In Relation To The Withdrawal Of Life-Sustaining Treatment In The Intensive Care Unit, Fiona Foxall, Deborah Sundin, Amanda Towell-Barnard Phd, Mnursing, Beverly Ewens, Vivien Kemp, Davina Porock

Research outputs 2014 to 2021

This paper considers the effectiveness of narrative inquiry as a research method in collecting and analyzing stories from a purposive sample of intensive care nurses and doctors, regarding their perceptions of the factors that influence decision-making in relation to the withdrawal of life sustaining treatment. Delaying the withdrawal of treatment when it is clearly indicated, may result in unnecessary patient suffering at the end of life, distress for the family as well as moral distress for staff. In narrative inquiry participants’ first-hand accounts of their experiences are told through story; the focus of analysis is the story, with the story …

Cdk5 Positively Regulates Notch1 Signaling In Pancreatic Cancer Cells By Phosphorylation, Qiaoyun Chu, Liyong Wang, Jie Zhang, Wei Wang, Youxin Wang

Research outputs 2014 to 2021

The marked overexpression of cyclin-dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has demonstrated that CDK5 inhibition disrupts Notch1 functions in human umbilical vein endothelial cells, the mechanism underlying Notch1 activation regulated by CDK5 remains unclear. Herein, we identified a physical interaction between CDK5 and Notch1 in PDAC cells, with the Notch1 peptide phosphorylated by CDK5/p25 kinase. CDK5 blockade resulted in the profound inhibition of Notch signaling. Accordingly, CDK5 inhibition sensitized PDAC cell proliferation and migration following …