Medicine and Health Sciences Commons^™

Intensive Care Nurse-Family Engagement From A Global Perspective: A Qualitative Multi-Site Exploration, Rahel Naef, Petra Brysiewicz, Natalie S. Mc Andrew, Patricia Beierwaltes, Vico Chiang, David Clisbee, Jennifer De Beer, Junko Honda, Shota Kakazu, Martin Nagl-Cupal, Ann M. Price, Sandra Richardson, Anna Richardson, Tara Tehan, Amanda Towell-Barnard, Sandra Eggenberger

Research outputs 2014 to 2021

Background: Critical illness is distressing for families, and often results in negative effects on family health that influence a family's ability to support their critically ill family member. Although recent attention has been directed at improving care and outcomes for families of critically ill patients, the manner in which nurses engage with families is not fully understood. Objectives: To describe nurses’ perceptions and practices of family engagement in adult intensive care units from a global perspective. Design: A qualitative-descriptive multi-site design using content analysis. Settings: The study was conducted in 26 intensive care units of 12 urban, metropolitan, academic medical …

Evaluating The Energetics Of Entrainment In A Human–Machine Coupled Oscillator System, Ryan T. Schroeder, James L. Croft, John E. A. Bertram

Research outputs 2014 to 2021

During locomotion, humans sometimes entrain (i.e. synchronize) their steps to external oscillations: e.g. swaying bridges, tandem walking, bouncy harnesses, vibrating treadmills, exoskeletons. Previous studies have discussed the role of nonlinear oscillators (e.g. central pattern generators) in facilitating entrainment. However, the energetics of such interactions are unknown. Given substantial evidence that humans prioritize economy during locomotion, we tested whether reduced metabolic expenditure is associated with human entrainment to vertical force oscillations, where frequency and amplitude were prescribed via a custom mechatronics system during walking. Although metabolic cost was not significantly reduced during entrainment, individuals expended less energy when the oscillation forces …

Prevalence And Patterns Of Multimorbidity In Australian Baby Boomers: The Busselton Healthy Ageing Study, Michael L. Hunter, Matthew W. Knuiman, Bill A. W. Musk, Jennie Hui, Kevin Murray, John P. Beilby, David R. Hillman, Joseph Hung, Robert U. Newton, Romola S. Bucks, Leon Straker, John P. Walsh, Kun Zhu, David G. Bruce, Robert H. Eikelboom, Timothy M. E. Davis, David A. Mackey, Alan L. James

Research outputs 2014 to 2021

Background and objective: Chronic medical conditions accumulate within individuals with age. However, knowledge concerning the trends, patterns and determinants of multimorbidity remains limited. This study assessed the prevalence and patterns of multimorbidity using extensive individual phenotyping in a general population of Australian middle-aged adults. Methods: Participants (n = 5029, 55% female), born between 1946 and 1964 and attending the cross-sectional phase of the Busselton Healthy Ageing Study (BHAS) between 2010 and 2015, were studied. Prevalence of 21 chronic conditions was estimated using clinical measurement, validated instrument scores and/or self-reported doctor-diagnosis. Non-random patterns of multimorbidity were explored using observed/expected (O/E) prevalence …

Feasibility, Tolerance And Effects Of Adding Impact Loading Exercise To Pulmonary Rehabilitation In People With Chronic Obstructive Pulmonary Disease: Study Protocol For A Pilot Randomised Controlled Trial, Erin Cecins, Kylie Hill, Dennis R. Taaffe, David Manners, Anne-Marie Hill, Robert U. Newton, Daniel A. Galvão, Vinicius Cavalheri

Research outputs 2014 to 2021

Background:

Chronic obstructive pulmonary disease (COPD) is a disorder linked with a multitude of extra pulmonary manifestations (also known as treatable traits), including low bone mineral density (BMD). To date, no specific guidelines exist for the management of BMD in this population. Impact loading exercise has been identified as an intervention that improves or maintains BMD in other populations. However, the feasibility of and tolerance to impact loading exercise has not been tested in people with COPD. The aim of the proposed study will be to investigate the feasibility and tolerance of adding impact loading exercise to a standard pulmonary …

Usability, Acceptability, And Safety Analysis Of A Computer-Tailored Web-Based Exercise Intervention (Exerciseguide) For Individuals With Metastatic Prostate Cancer: Multi-Methods Laboratory-Based Study, Holly E. L. Evans, Cynthia C. Forbes, Daniel A. Galvão, Corneel Vandelanotte, Robert U. Newton, Gary Wittert, Suzanne Chambers, Andrew D. Vincent, Ganessan Kichenadasse, Danielle Girard, Nicholas Brook, Camille E. Short

Research outputs 2014 to 2021

Background:

Digital health interventions such as tailored websites are emerging as valuable tools to provide individualized exercise and behavioral change information for individuals diagnosed with cancer.

Objective:

The aim of this study is to investigate and iteratively refine the acceptability and usability of a web-based exercise intervention (ExerciseGuide) for men with metastatic prostate cancer and determine how well individuals can replicate the video-based exercise prescription.

Methods:

A laboratory-based multi-methods design was used, incorporating questionnaires, think-aloud tests, interviews, and movement screening among 11 men aged 63 to 82 years with metastatic prostate cancer. Overall, 9 participants were undergoing androgen deprivation therapy, …

Play In Children With Neurodevelopmental Disorders: Psychometric Properties Of A Parent Report Measure ‘My Child’S Play’, Dulce Romero-Ayuso, María Ruiz-Salcedo, Sabina Barrios-Fernández, José Matías Triviño-Juárez, Donald Maciver, Janet Richmond, Miguel A. Muñoz

Research outputs 2014 to 2021

Play is essential in childhood, allowing for a positive trend in development and learning. Health professionals need useful tools to assess it, especially in the case of children with neurodevelopmental disorders. The aim of this study was to validate and cross-culturally adapt the My Child’s Play questionnaire and to find out if this instrument allows us to differentiate the play of children with neurodevelopmental disorders from the play of children with neurotypical development. A total of 594 parents completed the questionnaire. A confirmatory factor analysis was conducted, which showed a similar structure to the English version: (1) executive functions; (2) …

The Role Of Acceptance And Commitment Therapy In Cardiovascular And Diabetes Healthcare: A Scoping Review, Amineh Rashidi, Lisa Whitehead, Lisa Newson, Felicity Astin, Paramjit Gill, Deirdre A. Lane, Gregory Y. H. Lip, Lis Neubeck, Chantal F. Ski, David R. Thompson, Helen Walthall, Ian D. Jones

Research outputs 2014 to 2021

Acceptance and commitment therapy (ACT) is an adapted form of cognitive behavioural therapy. ACT focuses on how thinking affects behaviour and promotes psychological flexibility. The prevalence of psychological distress among people living with cardiovascular disease (CVD) and/or type 2 diabetes mellitus (T2DM) is high, and ACT may offer an alternative treatment approach. This scoping review explored the use of ACT as an intervention to support adults living with CVD and/or T2DM. A systematic search of the literature resulted in the inclusion of 15 studies. Studies were reviewed using the Joanna Briggs Institute approach to conducting scoping reviews. Most studies (n …

Impact Of Modern Antiviral Therapy Of Chronic Hepatitis B And C On Clinical Outcomes Of Liver Disease, Tiffany Khoo, Danielle Lam, John K. Olynyk

Research outputs 2014 to 2021

Chronic infections with the hepatitis B and C viruses have significant worldwide health and economic impacts. Previous treatments for hepatitis C such as interferon and ribavirin therapy were ineffective and poorly tolerated by patients. The introduction of directly acting curative antiviral therapy for hepatitis C and the wider use of nucleos(t)ide analogues for suppression of chronic Hepatitis B infection have resulted in many positive developments. Decreasing the prevalence of hepatitis B and C have concurrently reduced transmission rates and hence, the number of new infections. Antiviral treatments have decreased the rates of liver decompensation and as a result, lowered hospitalisation …

Effects Of Exercise During Radiotherapy On Physical Function And Treatment-Related Side Effects In Men With Prostate Cancer: A Systematic Review And Meta-Analysis, Oliver Schumacher, Hao Luo, Dennis Taaffe, Daniel A. Galvao, Colin Tang, Raphael Chee, Nigel Spry, Robert Newton

Research outputs 2014 to 2021

Purpose

Radiation therapy is a commonly used treatment for prostate cancer; however, the side effects may negatively affect quality of life and cause patients to be less physically active. Although exercise has been shown to mitigate radiation therapy–related fatigue in men with prostate cancer during radiation therapy, other adverse effects of treatment such as physical deconditioning, urinary symptoms, or sexual dysfunction have not been systematically reviewed in this patient population. Thus, the purpose of this review was to investigate the effect of exercise on physical function and treatment-related side effects in men with prostate cancer undergoing radiation therapy.

Methods

A …

An Integrated Multicomponent Care Model For Men Affected By Prostate Cancer: A Feasibility Study Of Truenth Australia, Patsy Yates, Rob Carter, Robyn Cockerell, Donna Cowan, Cyril Dixon, Anne Magnus, Robert U. Newton, Nicolas H. Hart, Daniel A. Galvão, Brenton Baguley, Nicholas Denniston, Tina Skinner, Jeremy Couper, Jon Emery, Mark Frydenberg, Wei-Hong Liu

Research outputs 2014 to 2021

Objective: To evaluate the feasibility of implementing an integrated multicomponent survivorship care model for men affected by prostate cancer. Methods: Using a single arm prospective cohort study design, men with prostate cancer were recruited from two regional public hospitals in Australia for a 6-months program that provided information and decision support, exercise and nutrition management, specialised clinical support, and practical support through localised and central care coordination. Carers of the men were also invited to the program. Data were collected from multiple sources to evaluate: (1) recruitment capability and participant characteristics; (2) appropriateness and feasibility of delivering the specific intervention …

All Around Suboptimal Health — A Joint Position Paper Of The Suboptimal Health Study Consortium And European Association For Predictive, Preventive And Personalised Medicine, Wei Wang, Yuxiang Yan, Zheng Guo, Haifeng Hou, Monique Garcia, Xuerui Tan, Enoch O. Anto, Gehendra Mahara, Yulu Zheng, Bo Li, Timothy Kang, Zhaohua Zhong, Youxin Wang, Xiuhua Guo, Olga Golubnitschaja, Suboptimal Health Study Consortium And European Association For Predictive, Preventive And Personalised Medicine

Research outputs 2014 to 2021

First two decades of the twenty-first century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The time-frame between onset of SHS and clinical manifestation …

Changes In Plasma C1q, Apelin And Adropin Concentrations In Older Adults After Descending And Ascending Stair Walking Intervention, Trevor C. Chen, Tsang-Hai Huang, Wei-Chin Tseng, Kuo-Wei Tseng, Chung-Chan Hsieh, Mei-Yen Chen, Tai-Ying Chou, Yuh-Chuan Huang, Hsin-Lian Chen, Kazunori Nosaka

Research outputs 2014 to 2021

This study compared changes in plasma complement component 1q (C1q), apelin and adropin concentrations in older obese women after descending (DSW) and ascending stair walking (ASW) training (n = 15/group) performed twice a week for 12 weeks, with gradual increases in exercise time from 5 to 60 min. Fasting blood samples were collected 3 days before the first and 4 days after the last training session. The improvements in the maximal voluntary isometric contraction (MVIC) strength of the knee extensors, functional physical fitness [e.g., 30-s chair stand (CS) performance], resting systolic blood pressure (SBP), insulin sensitivity [e.g., oral glucose tolerance …

The Tumor Suppressor Mir-642a-5p Targets Wilms Tumor 1 Gene And Cell-Cycle Progression In Prostate Cancer, Dianne J. Beveridge, Kirsty L. Richardson, Michael R. Epis, Rikki A. M. Brown, Lisa M. Stuart, Andrew J. Woo, Peter J. Leedman

Research outputs 2014 to 2021

RNA-based therapeutics are emerging as innovative options for cancer treatment, with microRNAs being attractive targets for therapy development. We previously implicated microRNA-642a-5p (miR-642a-5p) as a tumor suppressor in prostate cancer (PCa), and here we characterize its mode of action, using 22Rv1 PCa cells. In an in vivo xenograft tumor model, miR-642a-5p induced a significant decrease in tumor growth, compared to negative control. Using RNA-Sequencing, we identified gene targets of miR-642a-5p which were enriched for gene sets controlling cell cycle; downregulated genes included Wilms Tumor 1 gene (WT1), NUAK1, RASSF3 and SKP2; and upregulated genes included IGFBP3 and GPS2. Analysis of …

Cross-Education And Detraining Effects Of Eccentric Vs. Concentric Resistance Training Of The Elbow Flexors, Shigeru Sato, Riku Yoshida, Ryosuke Kiyono, Kaoru Yahata, Koki Yasaka, Kazunori (Ken) Nosaka, Masatoshi Nakamura

Research outputs 2014 to 2021

Background: Unilateral resistance training increases the strength of the contralateral non-trained homologous muscles known as the cross-education effect. We tested the hypothesis that unilateral eccentric resistance training (ET) would induce greater and longer-lasting cross-education effect when compared with concentric resistance training (CT). Methods: Young (20–23 y) participants were allocated to ET (5 males, 4 females) or CT (5 males, 4 females) group that performed unilateral progressive ET or CT of the elbow flexors, twice a week for 5 weeks (10 sessions) followed by a 5-week detraining, and control group (7 males, 6 females) that did not perform any training. Maximum …

No Casual Relationship Between T2dm And The Risk Of Infectious Diseases: A Two-Sample Mendelian Randomization Study, Huachen Wang, Zheng Guo, Yulu Zheng, Chunyan Yu, Haifeng Hou, Bing Chen

Research outputs 2014 to 2021

Background: In epidemiological studies, it has been proven that the occurrence of type 2 diabetes mellitus (T2DM) is related to an increased risk of infectious diseases. However, it is still unclear whether the relationship is casual. Methods: We employed a two-sample Mendelian randomization (MR) to clarify the causal effect of T2DM on high-frequency infectious diseases: sepsis, skin and soft tissue infections (SSTIs), urinary tract infections (UTIs), pneumonia, and genito-urinary infection (GUI) in pregnancy. And then, we analyzed the genome-wide association study (GWAS) meta-analysis of European-descent individuals and conducted T2DM-related single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) that were associated with …

Profile Of Immunoglobulin G N-Glycome In Covid-19 Patients: A Case-Control Study, Haifeng Hou, Huan Yang, Pengcheng Liu, Changwu Huang, Meng Wang, Yuejin Li, Mingsong Zhu, Jing Wang, Yuan Xu, Youxin Wang, Qingwei Ma, Dong Li, Pu Liao, Wei Wang

Research outputs 2014 to 2021

Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in …

Inconsistent Use Of Resistance Exercise Names In Research Articles: A Brief Note, James L. Nuzzo

Research outputs 2014 to 2021

Academic fields require standard nomenclature to communicate concepts effectively. Previous research has documented resistance training exercises are named inconsistently. This inconsistent use has been observed among fitness professionals and within resistance training textbooks. The purpose of the current note was to explore inconsistent use of resistance training exercise names in scientific articles. Keyword searches were performed in PubMed to identify articles that referred to 4 different resistance training exercises. The search was limited to titles and abstracts of articles published between 1960 and 2020. For exercise 1, "shoulder press," "overhead press," and "military press" were searched. For exercise 2, "arm …

Cannabinoid Exposure As A Major Driver Of Pediatric Acute Lymphoid Leukaemia Rates Across The Usa: Combined Geospatial, Multiple Imputation And Causal Inference Study, Albert Stuart Reece, Gary K. Hulse

Research outputs 2014 to 2021

Background: Acute lymphoid leukaemia (ALL) is the commonest childhood cancer whose incidence is rising in many nations. In the USA, between 1975 and 2016, ALL rates (ALLRs) rose 93.51% from 1.91 to 3.70/100,000 < 20 years. ALL is more common in Caucasian-Americans than amongst minorities. The cause of both the rise and the ethnic differential is unclear, however, prenatal cannabis exposure was previously linked with elevated childhood leukaemia rates. We investigated epidemiologically if cannabis use impacted nationally on ALLRs, its ethnic effects, and if the relationship was causal. Methods: State data on overall, and ethnic ALLR from the Surveillance Epidemiology and End Results databank of the Centre for Disease Control (CDC) and National Cancer Institute (NCI) were combined with drug (cigarettes, alcoholism, cannabis, analgesics, cocaine) use data from the National Survey of Drug Use and Health; 74.1% response rate. Income and ethnicity data was from the US Census bureau. Cannabinoid concentration was from the Drug Enforcement Agency Data. Data was analyzed in R by robust and spatiotemporal regression. Results: In bivariate analyses a dose-response relationship was demonstrated between ALLR and Alcohol Use Disorder (AUD), cocaine and cannabis exposure, with the effect of cannabis being strongest (β-estimate = 3.33(95%C.I. 1.97, 4.68), P = 1.92 × 10− 6). A strong effect of cannabis use quintile on ALLR was noted (Chi.Sq. = 613.79, P = 3.04 × 10− 70). In inverse probability weighted robust regression adjusted for other substances, income and ethnicity, cannabis was independently significant (β-estimate = 4.75(0.48, 9.02), P = 0.0389). In a spatiotemporal model adjusted for all drugs, income, and ethnicity, cannabigerol exposure was significant (β-estimate = 0.26(0.01, 0.52), P = 0.0444), an effect increased by spatial lagging (THC: β-estimate = 0.47(0.12, 0.82), P = 0.0083). After missing data imputation ethnic cannabis exposure was significant (β-estimate = 0.64(0.55, 0.72), P = 3.1 × 10− 40). 33/35 minimum e-Values ranged from 1.25 to 3.94 × 1036 indicative of a causal relationship. Relaxation of cannabis legal paradigms had higher ALLR (Chi.Squ.Trend = 775.12, P = 2.14 × 10− 112). Cannabis legal states had higher ALLR (2.395 ± 0.039 v. 2.127 ± 0.008 / 100,000, P = 5.05 × 10− 10). Conclusions: Data show that ALLR is associated with cannabis consumption across space-time, is associated with the cannabinoids, THC, cannabigerol, cannabinol, cannabichromene, and cannabidiol, contributes to ethnic differentials, demonstrates prominent quintile effects, satisfies criteria for causality and is exacerbated by cannabis legalization.

Adaptations To Post-Exercise Cold Water Immersion: Friend, Foe, Or Futile?, Mohammed Ihsan, Chris R. Abbiss, Robert Allan

Research outputs 2014 to 2021

In the last decade, cold water immersion (CWI) has emerged as one of the most popular post-exercise recovery strategies utilized amongst athletes during training and competition. Following earlier research on the effects of CWI on the recovery of exercise performance and associated mechanisms, the recent focus has been on how CWI might influence adaptations to exercise. This line of enquiry stems from classical work demonstrating improved endurance and mitochondrial development in rodents exposed to repeated cold exposures. Moreover, there was strong rationale that CWI might enhance adaptations to exercise, given the discovery, and central role of peroxisome proliferator-activated receptor gamma …

Pattern And Degree Of Individual Brain Atrophy Predicts Dementia Onset In Dominantly Inherited Alzheimer's Disease, Ophir Keret, Adam M. Staffaroni, John M. Ringman, Yann Cobigo, Sheng-Yang M. Goh, Amy Wolf, Isabel Elaine Allen, Stephen Salloway, Jasmeer Chhatwal, Adam M. Brickman, Dolly Reyes-Dumeyer, Randal J. Bateman, Tammie L.S. Benzinger, John C. Morris, Beau M. Ances, Nelly Joeseph-Mathurin, Richard J. Perrin, Brian A. Gordon, Johannes Levin, Jonathan Voglein, Mathias Jucker, Christian La Fougere, Ralph N. Martins, Hamid R. Sohrabi, Kevin Taddei, Victor L. Villemagne, Peter R. Schofield, William S. Brooks, Michael Fulham, Colin L. Masters, Bernardino Ghetti, Andrew J. Saykin, Clifford R. Jack, Neill R. Graff-Radford, Michael Weiner, David M. Cash, Ricardo F. Allegri, Patricio Chrem, Su Yi, Bruce L. Miller, Gil D. Rabinovici, Howard J. Rosen, Dominantly Inherited Alzheimer Network

Research outputs 2014 to 2021

Introduction: Asymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD-MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. Brain atrophy is an early feature of DIAD-MC and could help predict risk for dementia during trial enrollment. Methods: We created a dementia risk score by entering standardized gray-matter volumes from 231 DIAD-MC into a logistic regression to classify participants with and without dementia. The score's predictive utility was assessed using Cox models and receiver operating curves on a separate group of 65 DIAD-MC followed longitudinally. Results: Our risk score separated asymptomatic versus demented …

A Delirium Prevalence Audit And A Pre And Post Evaluation Of An Interprofessional Education Intervention To Increase Staff Knowledge About Delirium In Older Adults, Bev Ewens, Karla Seaman, Lisa Whitehead, Mandy Towell-Barnard, Michelle Young

Research outputs 2014 to 2021

Background

Delirium is more prevalent in older people and estimated to occur in up to 50% of the hospital population. Delirium comprises a spectrum of behaviours, including cognitive and attention deficits, and fluctuating levels of consciousness, often associated with an underlying physiological disturbance. Delirium has been increasingly associated with adverse outcomes. Although often preventable or can at least be mitigated, delirium may not be a standard part of assessment and thus may not be recognized in the early stages when it is most likely to be treated successfully. The aim of this study was to evaluate the level of knowledge …

Whole Fat Dairy Products Do Not Adversely Affect Adiposity Or Cardiometabolic Risk Factors Inchildren In The Milky Way Study: A Double Blind Randomized Controlled Pilot Study, Analise Nicholl, Kane Deering, Kate J. Evelegh, Philippa Lyons-Wall, David Lawrence, Trevor A. Mori, Mario Kratz, Therese O'Sullivan

Research outputs 2014 to 2021

Background

Limited evidence supports the common public health guideline that children > 2 y of age should consume dairy with reduced fat content.

Objectives

We aimed to investigate the effects of whole-fat compared with reduced-fat dairy intake on measures of adiposity and biomarkers of cardiometabolic risk in healthy 4- to 6-y-old children.

Methods

The Milky Way Study enrolled 49 children (mean ± SD age: 5.2 ± 0.9 y; 47% girls) who were habitual consumers of whole-fat dairy, then randomly assigned them in a double-blind fashion to remain on whole-fat dairy or switch their dairy consumption to reduced-fat products for 3 mo. …

Low-Coverage Whole-Genome Sequencing Of Extracellular Vesicle-Associated Dna In Patients With Metastatic Cancer, Bella Nguyen, Nicholas C. Wong, Tim Semple, Michael Clark, Stephen Q. Wong, Connull Leslie, Bob Mirzai, Michael Millward, Katie Meehan, Annette M. Lim

Research outputs 2014 to 2021

© 2021, The Author(s). Low-coverage whole-genome sequencing (LC-WGS) can provide insight into oncogenic molecular changes. Serum extracellular vesicles (EV) represent a novel liquid biopsy source of tumoral DNA. This study compared copy number alteration (CNA) profiles generated from LC-WGS of formalin-fixed paraffin-embedded (FFPE) tumoral DNA and EV-DNA obtained from cancer patients. Patients with squamous cell carcinoma of the base of tongue (n = 3) and cutaneous squamous cell carcinoma (n = 2) were included. LC-WGS (0.5-1X coverage) was performed on FFPE-DNA and serum EV-DNA. Similarity between CNA profiles was analysed using QDNAseq. FFPE samples had a mean CNA of 31 …

Motor Developmental Outcomes In Children Exposed To Maternal Diabetes During Pregnancy: A Systematic Review And Meta-Analysis, Diana Arabiat, Mohammad A. L. Jabery, Vivien Kemp, Mark Jenkins, Lisa C. Whitehead, Gary Adams

Research outputs 2014 to 2021

© 2021 by the author. Licensee MDPI, Basel, Switzerland. Studies on the association of maternal diabetes with motor development in children provide inconsistent findings. We searched MEDLINE/PubMed, EMBASE, Emcare, PsycINFO, and Google Scholar databases for primary observational, case–control, or cohort studies that report on the motor development of children exposed to maternal diabetes during pregnancy. Quality appraisal and data extraction were performed independently and in duplicate. A meta-analysis of summary measures was performed using random-effect models. Eighteen studies were identified for inclusion, however, only 13 were included in the meta-analysis. Exposure to maternal diabetes during pregnancy was associated with a …

Injury Deaths In Australian Sport And Recreation: Identifying And Assessing Priorities For Prevention, Lauren V. Fortington, Andrew S. Mcintosh, Caroline F. Finch

Research outputs 2014 to 2021

Introduction

Sport and recreation is beneficial for health and wellbeing but comes with a probability of loss, including occasional fatal injuries. Following high-profile injury deaths in Australia, concerns are raised regarding the safety of sport participation. To understand the scale and scope of injury deaths, and identify potential prevention opportunities, the aim of this investigation was to describe the number and nature of fatal injuries in Australian sport and recreation.

Methods

This is a retrospective cohort study of injury deaths reported between 1 July 2000 to 31 December 2019 using data from the National Coronial Information System, Australia. Unintentional deaths …

Effect Of Oral Rehydration Solution Versus Spring Water Intake During Exercise In The Heat On Muscle Cramp Susceptibility Of Young Men, Wing Yin Lau, Haruyasu Kato, Kazunori Nosaka

Research outputs 2014 to 2021

Background

Muscle cramp is a painful, involuntary muscle contraction, and that occurs during or following exercise is referred to as exercise-associated muscle cramp (EAMC). The causes of EAMC are likely to be multifactorial, but dehydration and electrolytes deficits are considered to be factors. This study tested the hypothesis that post-exercise muscle cramp susceptibility would be increased with spring water ingestion, but reduced with oral rehydration solution (ORS) ingestion during exercise.

Methods

Ten men performed downhill running (DHR) in the heat (35–36 °C) for 40–60 min to reduce 1.5–2% of their body mass in two conditions (spring water vs ORS) …

Chronic Nitrite Treatment Activates Adenosine Monophosphate-Activated Protein Kinase-Endothelial Nitric Oxide Synthase Pathway In Human Aortic Endothelial Cells, Yang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Mori, Natalie C. Ward

Research outputs 2014 to 2021

Endothelial dysfunction, with impaired bioavailability and/or bioactivity of the vasoprotective molecule, nitric oxide, appears to be a vital step in the initiation of atherosclerosis. Several studies have shown that dietary nitrate/nitrite can have significant benefits on human cardiovascular homeostasis. Although serum nitrite concentrations can reach micromolar levels, the physiological significance of nitrate/nitrite in normal tissues has not been fully elucidated. We investigated in vitro the chronic effects of nitrate/nitrite on endothelial nitric oxide synthase (eNOS) to determine the potential vasoprotective effects of nitrate/nitrite and the underlying molecular mechanisms. Our results demonstrate the expression of phosphorylated eNOS at Ser1177 and phosphorylated …

Tweak/Fn14 Signalling Promotes Cholangiocarcinoma Niche Formation And Progression, Benjamin J. Dwyer, Edward J. Jarman, Jully Gogoi-Tiwari, Sofia Ferreira-Gonzalez, Luke Boulter, Rachel V. Guest, Timothy J. Kendall, Dominic Kurian, Alastair M. Kilpatrick, Andrew J. Robson, Eoghan O'Duibhir, Tak Yung Man, Lara Campana, Philip J. Starkey Lewis, Stephen J. Wigmore, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker, Stuart J. Forbes

Research outputs 2014 to 2021

Background & Aims: Cholangiocarcinoma (CCA) is a cancer of the hepatic bile ducts that is rarely resectable and is associated with poor prognosis. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is known to signal via its receptor fibroblast growth factor-inducible 14 (Fn14) and induce cholangiocyte and myofibroblast proliferation in liver injury. We aimed to characterise its role in CCA. Methods: The expression of the TWEAK ligand and Fn14 receptor was assessed immunohistochemically and by bulk RNA and single cell transcriptomics of human liver tissue. Spatiotemporal dynamics of pathway regulation were comprehensively analysed in rat and mouse models of thioacetamide …

Process Development And Safety Evaluation Of Abcb5+ Limbal Stem Cells As Advanced-Therapy Medicinal Product To Treat Limbal Stem Cell Deficiency, Alexandra Norrick, Jasmina Esterlechner, Elke Niebergall-Roth, Ulf Dehio, Samar Sadeghi, Hannes M. Schröder, Seda Ballikaya, Nicole Stemler, Christoph Ganss, Kathrin Dieter, Ann-Kathrin Dachtler, Patrick Merz, Saadettin Sel, James Chodosh, Claus Cursiefen, Natasha Y. Frank, Gerd U. Auffarth, Bruce Ksander, Markus H. Frank, Mark A. Kluth

Research outputs 2014 to 2021

Background: While therapeutic success of the limbal tissue or cell transplantation to treat severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the percentage of LSCs within the transplanted cells, prospective LSC enrichment has been hampered by the intranuclear localization of the previously reported LSC marker p63. The recent identification of the ATP-binding cassette transporter ABCB5 as a plasma membrane-spanning marker of LSCs that are capable of restoring the cornea and the development of an antibody directed against an extracellular loop of the ABCB5 molecule stimulated us to develop a novel treatment strategy based on the utilization …

Standardisation Of Clinical Assessment, Management And Follow-Up Of Acute Hospitalised Exacerbation Of Copd: A Europe-Wide Consensus, Sanjay Ramakrishnan, Wim Janssens, Pierre R. Burgel, Marco Contoli, Frits M. E. Franssen, Neil J. Greening, Timm Greulich, Iwein Gyselinck, Andreas Halner, Arturo Huerta, Rebecca L. Morgan, Jennifer K. Quint, Lowie E. G. W. Vanfleteren, Kristina Vermeersch, Henrik Watz, Mona Bafadhel

Research outputs 2014 to 2021

Background: Despite hospitalization for exacerbation being a high-risk event for morbidity and mortality, there is little consensus globally regarding the assessment and management of hospitalised exacerbations of COPD. We aimed to establish a consensus list of symptoms, physiological measures, clinical scores, patient questionnaires and investigations to be obtained at time of hospitalised COPD exacerbation and follow-up. Methods: A modified Delphi online survey with pre-defined consensus of importance, feasibility and frequency of measures at hospitalisation and follow-up of a COPD exacerbation was undertaken. Findings: A total of 25 COPD experts from 18 countries contributed to all 3 rounds of the survey. …