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Articles 241 - 270 of 4977

Full-Text Articles in Medicine and Health Sciences

When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes At Aβ-Pet Centiloid 15, Mean Age Of 66 Years, Rodrigo Cánovas, Timothy Cox, Vincent Doré, Pierrick Bourgeat, Jurgen Fripp, Azadeh Feizpour, Rosita Shishegar, Christopher J. Fowler, Simon M. Laws, Tenielle Porter, Stephanie Rainey-Smith, Leslie M. Shaw, Randall J. Bateman, Yan Li, Ovod Vitaliy, Michael W. Weiner, John C. Morris, Tammie L.S. Benzinger, Suzanne E. Schindler, Akinori Nakamura, Takeshi Iwatsubo, Takeshi Ikeuchi, Takashi Kato, Paul Maruff, Hamid R. Sohrabi, Christopher C. Rowe, Ralph Martins, Colin L. Masters, James Doecke Jan 2026

When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes At Aβ-Pet Centiloid 15, Mean Age Of 66 Years, Rodrigo Cánovas, Timothy Cox, Vincent Doré, Pierrick Bourgeat, Jurgen Fripp, Azadeh Feizpour, Rosita Shishegar, Christopher J. Fowler, Simon M. Laws, Tenielle Porter, Stephanie Rainey-Smith, Leslie M. Shaw, Randall J. Bateman, Yan Li, Ovod Vitaliy, Michael W. Weiner, John C. Morris, Tammie L.S. Benzinger, Suzanne E. Schindler, Akinori Nakamura, Takeshi Iwatsubo, Takeshi Ikeuchi, Takashi Kato, Paul Maruff, Hamid R. Sohrabi, Christopher C. Rowe, Ralph Martins, Colin L. Masters, James Doecke

Research outputs 2022 to 2026

Objective: Sporadic late-onset Alzheimer's disease (AD) is characterized by a long pre-clinical phase where amyloid-beta (Aβ) and tau begin to accumulate in the brain. The primary objective was to determine the age at which AD starts by finding the average population age when both positron emission tomography (PET) Aβ (Aβ-PET) and plasma Aβ42/40 become abnormal. Methods: Two high performance immunoprecipitation-mass spectrometry (IP-MS) assays (WashU/C2N and Shimadzu) were tested on samples from 1,450 participants who were diagnosed as cognitively unimpaired (CU), mild cognitive impairment (MCI), or AD-dementia across 4 international cohorts. Natural history modeling and trajectory analyses of the combined Aβ-PET …

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Association Between Protein Intake From Animal And Plant Sources And The Presence Of Frailty In Community-Dwelling Australian Women, Trent Bozanich, Jack Dalla Via, Simone Radavelli-Bagatini, Cassandra Smith, Elsa Dent, Anthony Villani, Robin M. Daly, Michael Tieland, Jonathan M. Hodgson, Kun Zhu, Richard L. Prince, Marc Sim Jan 2026

Association Between Protein Intake From Animal And Plant Sources And The Presence Of Frailty In Community-Dwelling Australian Women, Trent Bozanich, Jack Dalla Via, Simone Radavelli-Bagatini, Cassandra Smith, Elsa Dent, Anthony Villani, Robin M. Daly, Michael Tieland, Jonathan M. Hodgson, Kun Zhu, Richard L. Prince, Marc Sim

Research outputs 2022 to 2026

We investigated the cross-sectional association between total, animal and plant protein intake with the presence of a multidimensional measure of frailty in older women. Participants included 1380 community-dwelling Australian women, mean (SD) age 75.1 (2.7) years. A validated food frequency questionnaire was used to determine total, plant, and animal protein intake. Frailty was assessed using a frailty index across numerous health domains (scored 0–1, ≥0.25 indicating frailty). Cross-sectional associations were analysed using multivariable-adjusted logistic regression models. In total, 275 (19.9%) women were identified as frail. A non-linear inverse association was observed between higher intakes of total protein and the odds …

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Cohort Profile: The Resilient Minds National Study Of Mental Health And Cognitive Resilience In Community Dwelling Adults Aged 18 To 93, Kaarin J. Anstey, Brooke Brady, Lidan Zheng, Jana Koch, Md Hamidul Huque, Michelle K. Lupton, Ralph Martins, Daniel Ashworth, Erin Goddard, Nikki Anne Wilson, Claudia M. Hillenbrand, Ralf B. Loeffler, Maria Markoulli, Arun V. Krishnan, Tanya Layton, Ranmalee Eramudugolla Jan 2026

Cohort Profile: The Resilient Minds National Study Of Mental Health And Cognitive Resilience In Community Dwelling Adults Aged 18 To 93, Kaarin J. Anstey, Brooke Brady, Lidan Zheng, Jana Koch, Md Hamidul Huque, Michelle K. Lupton, Ralph Martins, Daniel Ashworth, Erin Goddard, Nikki Anne Wilson, Claudia M. Hillenbrand, Ralf B. Loeffler, Maria Markoulli, Arun V. Krishnan, Tanya Layton, Ranmalee Eramudugolla

Research outputs 2022 to 2026

Purpose: The Resilient Minds (ReMind) cohort was established to investigate cognitive and mental health resilience across the life course, addressing a gap in longitudinal evidence about resilience. The study collected data on traditional medical and lifestyle risk factors for chronic disease, genetics, and a range of mental health and cognitive outcomes. It also aimed to explore contemporary contextual influences on resilience, including internet use, social engagement, environmental exposures, and life course adversities such as perceived discrimination. Participants: The cohort included 1,640 adults aged 18–93 years, recruited through social media and community groups, to participate in a fully remote, two-year health …

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Diet, Gut Microbiota, And Intestinal Permeability: Emerging Mechanisms In Hypertension Pathogenesis, Esha Vashisht, Helen Nguyen, Francine Z. Marques, Matthew Snelson Jan 2026

Diet, Gut Microbiota, And Intestinal Permeability: Emerging Mechanisms In Hypertension Pathogenesis, Esha Vashisht, Helen Nguyen, Francine Z. Marques, Matthew Snelson

Research outputs 2022 to 2026

Hypertension is a leading contributor to global morbidity and mortality, arising from the interplay of genetic and environmental risk factors together with the dysregulation of multiple physiological systems involved in blood pressure control. Recent advances have established the gut as a central regulator, implicating the intestinal microbiota and barrier integrity in the modulation of blood pressure. Alterations in the gut microbial consortium, along with changes in levels of metabolites produced by the microbiota, have been associated with blood pressure regulation in animal models and human studies. Key microbial metabolites, including short-chain fatty acids, trimethylamine-N-oxide, and bile acids influence endothelial function, …

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Does Performing Partial Repetitions Beyond Momentary Failure Enhance Muscle Hypertrophy In Volume-Load-Equated Calf-Raise Resistance Training?, Amirali Goli, Parsa Attarieh, João Pedro Nunes, Saman Nehegadar, Saaed Khani, Mohmad Fashi, Sajjad Ahmadizad Jan 2026

Does Performing Partial Repetitions Beyond Momentary Failure Enhance Muscle Hypertrophy In Volume-Load-Equated Calf-Raise Resistance Training?, Amirali Goli, Parsa Attarieh, João Pedro Nunes, Saman Nehegadar, Saaed Khani, Mohmad Fashi, Sajjad Ahmadizad

Research outputs 2022 to 2026

The aim of this study was to determine whether extending traditional calf-raise resistance training sets with partial-range-of-motion (ROM) repetitions in the more dorsiflexed ROM enhances muscular hypertrophy. Sixteen untrained men (25.0±1.7y) completed 10 weeks of unilateral standing calf-raise training (2×/wk) in a within-subject design: one leg performed traditional 10-14RM sets to full-ROM momentary failure (MF; 4-6 sets/session) and the other leg performed half as many sets to full-ROM failure followed by partial-ROM repetitions to a second failure in the more dorsiflexed ROM (PBF; 2-3 sets/session). Total volume-load was equated between conditions; repetitions were counted the same way regardless of the …

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Effectiveness, Reach, Uptake, And Feasibility Of Digital Health Interventions For Culturally And Linguistically Diverse Populations Living With Prediabetes Across The Lifespan: Systematic Review And Meta-Analysis, Lisa Whitehead, Min Zhang, Wai Hang Kwok, Diana Arabiat, Amanda Towell Barnard Jan 2026

Effectiveness, Reach, Uptake, And Feasibility Of Digital Health Interventions For Culturally And Linguistically Diverse Populations Living With Prediabetes Across The Lifespan: Systematic Review And Meta-Analysis, Lisa Whitehead, Min Zhang, Wai Hang Kwok, Diana Arabiat, Amanda Towell Barnard

Research outputs 2022 to 2026

Background: Culturally and linguistically diverse (CaLD) populations are at a higher risk of developing prediabetes; however, the effectiveness and implementation of digital health interventions for prediabetes management in this population are not well understood. Objective: This review aims to evaluate the effectiveness and implementation of digital health interventions (DHIs) versus usual care for glycemic control in CaLD populations living with prediabetes. Methods: This review aimed to include people of any age living with prediabetes who are from a CaLD background. Experimental and quasi-experimental studies that compare digital health interventions to usual care, waitlist, or active control were eligible. The primary …

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Effects Of Maximal Versus Submaximal Intended Velocity Resistance Training On Muscular Fitness Adaptations In Older Adults: A Systematic Review And Meta-Analysis, Meiling Tao, Kaifang Liao, Mingyue Yin, Zhili Chen, Yuming Zhong, Chenwen Zhu, Yuou Song, Steve Thompson, Chris Bishop, Yongming Li Jan 2026

Effects Of Maximal Versus Submaximal Intended Velocity Resistance Training On Muscular Fitness Adaptations In Older Adults: A Systematic Review And Meta-Analysis, Meiling Tao, Kaifang Liao, Mingyue Yin, Zhili Chen, Yuming Zhong, Chenwen Zhu, Yuou Song, Steve Thompson, Chris Bishop, Yongming Li

Research outputs 2022 to 2026

Purpose: This systematic review aimed to: 1) explore muscular fitness adaptations (e.g., muscle mass, muscle strength, functional performance) in older adults (≥ 60 years) following exercise with resistance training compared to control; and 2) investigate the moderating effects of load intensity, training frequency, and movement velocity on muscular fitness adaptations.Methods: Four databases were searched (April 2024, updated 2025). Pooled effects for each outcome were summarized using Standardized Mean Difference (Hedges’ g) through a three-level meta-analysis model, and subgroup was used to explore moderators. The certainty of evidence was assessed using the GRADE approach.Results: Sixteen studies were eligible (n = 801), …

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Enhancing Physical Performance With Ischemic Preconditioning: A Systematic Review And Meta-Analysis Of Moderators And Performance Outcomes, Yilin Zhang, Kai Xu, Hao Kong, Mingyue Yin, Chenghao Liu, Yun Xie, Liam Kilduff, Gustavo R. Mota, Olivier Girard Jan 2026

Enhancing Physical Performance With Ischemic Preconditioning: A Systematic Review And Meta-Analysis Of Moderators And Performance Outcomes, Yilin Zhang, Kai Xu, Hao Kong, Mingyue Yin, Chenghao Liu, Yun Xie, Liam Kilduff, Gustavo R. Mota, Olivier Girard

Research outputs 2022 to 2026

This study examined the effects of ischemic preconditioning (IPC) on physical performance, considering the influence of timing, warm-up (WU), participant characteristics, and IPC protocols structure. A total of 90 trials (1,439 participants) were retrieved from three databases and assessed using PICOS criteria. Multilevel meta-analyses with cluster-robust variance adjustments were conducted to calculate pooled effect sizes (Hedge’s g). Risk of bias and certainty of evidence were assessed using the RoB 2 tool and GRADE framework. IPC produced a trivial but significant improvement in physical performance (g = 0.13, P < 0.01), which persisted after excluding SHAM effects (g = 0.10; P < 0.01). Significant improvements were observed for maximum repetitions, time to failure, and power output, but not for jump ability, strength, or oxygen uptake. Comparable benefits were found for anaerobic (g = 0.15) and aerobic (g = 0.10) exercise, with greater effects in males and less-trained participants. Performance was further enhanced when IPC was followed by WU (g = 0.16), with the optimal IPC-to-WU interval being ~42 minutes. Without WU, the effective IPC window narrowed to 6–7 minutes. In practice, IPC can enhance physical performance, independently of sham effects, moderated by sex, training level, and WU. For competition or testing, the most effective strategy appears to be 3 or 4 × 5-min IPC protocol, followed by a 42-min interval, standardized warm-up, and endurance testing. For mechanistic studies, WU should be excluded, and testing conducted 6-7 minutes post-IPC. Future research should target women, middle-aged individuals, and elite athletes.

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Influence Of Isometric Hamstring Assessment Modality: Asymmetries Across Bilateral And Unilateral Testing Procedures, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort Jan 2026

Influence Of Isometric Hamstring Assessment Modality: Asymmetries Across Bilateral And Unilateral Testing Procedures, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort

Research outputs 2022 to 2026

Purpose: The aim of this study was to evaluate whether unilateral and bilateral assessments display comparable results during the isometric long-lever bridge and to examine the directionality of asymmetry fluctuations across testing occasions. Methods: Forty-four participants comprising of 30 men (age: 19.4 ± 1.3 years; height: 179.8 ± 6.3 cm; body mass: 80.4 ± 10.3 kg) and 14 women (age: 20.0 ± 1.3 years; height: 166.9 ± 7.2 cm; body mass: 64.4 ± 7.4 kg) volunteered to participate in the study. All participants completed two separate testing sessions consisting of two maximal bilateral and unilateral repetitions respectively of the isometric …

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Longitudinal Prediction Of Bmi Using Explainable Ai: Integrating Polygenic Scores, Maternal, Early-Life And Familial Factors, Fuling Chen, Phillip E. Melton, Kevin Vinsen, Trevor Mori, Lawrence Beilin, Rae Chi Huang Jan 2026

Longitudinal Prediction Of Bmi Using Explainable Ai: Integrating Polygenic Scores, Maternal, Early-Life And Familial Factors, Fuling Chen, Phillip E. Melton, Kevin Vinsen, Trevor Mori, Lawrence Beilin, Rae Chi Huang

Research outputs 2022 to 2026

Background/objectives: This study aimed to predict body mass index (BMI) trajectories from childhood to early adulthood using explainable artificial intelligence, integrating adult BMI polygenic scores (PGS), maternal, early-life, and familial factors to identify key predictors of obesity risk and inform prevention strategies. Subjects/methods: We analyzed longitudinal data from the Raine Study Gen2 cohort, recruiting 2868 participants. This observational study, without randomization or case-control design, collected BMI measurements at ages 8, 10, 14, 17, 20, 23, and 27 years. We applied Kolmogorov–Arnold Networks (KAN) alongside conventional machine learning models, integrating epidemiological variables (maternal and paternal anthropometrics, parental education, early-life skinfold measurements) …

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Nurse Practitioner Students' Perceptions Of An Artificial Intelligence Differential Diagnosis Tool: A Pilot Study, Nilufeur Mckay, Peter Palamara, Adam Mccavery, Kaoru Nosaka, Wai Hang Kwok Jan 2026

Nurse Practitioner Students' Perceptions Of An Artificial Intelligence Differential Diagnosis Tool: A Pilot Study, Nilufeur Mckay, Peter Palamara, Adam Mccavery, Kaoru Nosaka, Wai Hang Kwok

Research outputs 2022 to 2026

Aim: The aim of this study is to assess nurse practitioner students' perceptions and engagement with Isabel's artificial intelligence (AI) based differential diagnosis tool to support their decision-making skills during their theoretical and clinical placement training. Design: This pilot study used a cross-sectional design. Methods: Twenty-six nurse practitioner students provided feedback on their use of an AI differential diagnosis tool in both academic and clinical contexts. This survey used the Post-Study System Usability Questionnaire to assess the engagement levels and usability of the AI tool. Additional questions were included to evaluate the usage patterns, adequacy in training and confidence in …

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One Of These Things Is Not Like The Others: Disentangling The Concepts Of Range Of Motion Versus Flexibility, And Flexibility Training Versus Stretching, José Afonso, Anthony J. Blazevich, David George Behm, Markus Tilp, Konstantin Warneke Jan 2026

One Of These Things Is Not Like The Others: Disentangling The Concepts Of Range Of Motion Versus Flexibility, And Flexibility Training Versus Stretching, José Afonso, Anthony J. Blazevich, David George Behm, Markus Tilp, Konstantin Warneke

Research outputs 2022 to 2026

In this Current Opinion, we revisit key terminological distinctions in sports sciences, emphasizing the implications of conflating related but distinct concepts, particularly range of motion (ROM) versus flexibility and flexibility training versus stretching. While often used interchangeably, these terms represent nuanced constructs with distinct physiological and practical implications. ROM encompasses both modifiable (e.g., soft tissue extensibility, neural control) and non-modifiable factors (e.g., bone structure), whereas flexibility is only one of several trainable components of ROM, largely referring to the extensibility of periarticular soft tissues. Misunderstanding these distinctions risks erroneous assessments and inappropriate exercise prescriptions. We also challenge the common practice …

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Sexuality Education In An Age Of Resistance: Reflections At The Nexus Of Education, Health And Rights, Sarah Vrankovich, Katrina Marson, Giselle Woodley, Jordina Quain, Hanna Saltis Jan 2026

Sexuality Education In An Age Of Resistance: Reflections At The Nexus Of Education, Health And Rights, Sarah Vrankovich, Katrina Marson, Giselle Woodley, Jordina Quain, Hanna Saltis

Research outputs 2022 to 2026

Comprehensive sexuality education (CSE) is internationally recognised as essential to public health and young people’s rights. Yet its implementation in Australia and globally is increasingly undermined by conservative backlash, moral panic and political interference. This paper offers a critical reflection on the current landscape of CSE, drawing on insights from a panel discussion at the 2025 World Association for Sexual Health congress, and collaborative analysis. As early-career researchers, sexologists and practitioners working across education, communications, public health and sexual violence prevention, we utilise our collective experience to examine how various influences shape and constrain the delivery of CSE. We map …

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Trial Tribulations: Lessons Learned From An Unsuccessful Pilot Trial Of Behavioural Activation In Young People With Early Or Emerging Psychosis At A Regional Mental Health Service, Janina Catalao Dionisio Murta, Bróna Nic Giolla Easpaig, Mitchell K. Byrne, Richard Gray, Martin Jones, David Mitchell, Rebecca Creek, Ellie Brown, Jing Yu Tan, Shaun Dennis, Daniel Bressington Jan 2026

Trial Tribulations: Lessons Learned From An Unsuccessful Pilot Trial Of Behavioural Activation In Young People With Early Or Emerging Psychosis At A Regional Mental Health Service, Janina Catalao Dionisio Murta, Bróna Nic Giolla Easpaig, Mitchell K. Byrne, Richard Gray, Martin Jones, David Mitchell, Rebecca Creek, Ellie Brown, Jing Yu Tan, Shaun Dennis, Daniel Bressington

Research outputs 2022 to 2026

AimThe experience of conducting an unsuccessful pilot trial of behavioural activation (BA) to improve depressive symptoms in young clients with early or emerging psychosis is reported on. We aimed to identify barriers and enablers to inform the conduct of future trials with this client group.MethodsClinicians completed BA training with the aim of delivering this to suitable clients. Feasibility outcomes were calculated as proportions of feasibility targets. The various stages of the pilot randomised trial were examined, informed by interviews with five young people with early or emerging psychosis and four clinicians. Interviews were content analysed.ResultsClient recruitment and retention targets were …

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Unifying To Advance Understanding: Collaborative, Community-Driven And ‘Open’ Approaches For Better Science In Sport, John Warmenhoven, Ian Shrier, Garrett S. Bullock, Alex O. Holcombe, Sophia Nimphius, Paolo Menaspà, Aaron J. Coutts, Franco M. Impellizzeri Jan 2026

Unifying To Advance Understanding: Collaborative, Community-Driven And ‘Open’ Approaches For Better Science In Sport, John Warmenhoven, Ian Shrier, Garrett S. Bullock, Alex O. Holcombe, Sophia Nimphius, Paolo Menaspà, Aaron J. Coutts, Franco M. Impellizzeri

Research outputs 2022 to 2026

Historically, sport science and medicine researchers have had difficulty obtaining adequate sample sizes, limiting their ability to make accurate generalizations to populations of athletes. To move towards better and more generalizable research, sport could look to other fields of research, and draw upon collaborative approaches for performing science. These include concepts such as big teams approaches for conducting experimental research, developing data repositories centred on a holistic inter-disciplinary view of the athlete and exploring privacy preserving meta-analytic inspired concepts such as federated analyses or pooled synthetic data. These approaches have enormous potential but do come with their own difficulties and …

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You Can Only Take Your Clients As Far As You’Ve Been Yourself: Examining The Intersections Between Psychedelic-Assisted Therapy, Lived-Living Experience, And Clinical Practice, Jordan J. Negrine, Stephen J. Bright, Monica J. Barratt, Matthew Pennell, Anthony Barnett, James Bennett-Levy, Timothy Piatkowski Jan 2026

You Can Only Take Your Clients As Far As You’Ve Been Yourself: Examining The Intersections Between Psychedelic-Assisted Therapy, Lived-Living Experience, And Clinical Practice, Jordan J. Negrine, Stephen J. Bright, Monica J. Barratt, Matthew Pennell, Anthony Barnett, James Bennett-Levy, Timothy Piatkowski

Research outputs 2022 to 2026

Background: Following Australia’s landmark 2023 decision to approve psilocybin and MDMA for clinical use, psychedelic-assisted therapy (PAT) is beginning to emerge within regulated mental health settings. This study investigates psychologists’ views on the relevance of psychedelic therapists’ lived-living experience (LLE) with psychedelics. While discussion around LLE is growing, little is known about how psychologists perceive its role in clinical preparedness for PAT. Methods: Twenty Australian psychologists were recruited through purposive and snowball sampling. Semi-structured interviews explored perceptions of LLE in therapist training and practice. Data were coded and thematically analyzed to identify patterns in how experiential knowledge is valued within …

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A Case For Qualitatively Driven Mixed Methods In Nursing Research: A Methodological Discussion, Jennifer Hamilton, Cooper, Irene Ngune, Amanda Cole, Richard Bostwick, Debbie Louise Massey Jan 2026

A Case For Qualitatively Driven Mixed Methods In Nursing Research: A Methodological Discussion, Jennifer Hamilton, Cooper, Irene Ngune, Amanda Cole, Richard Bostwick, Debbie Louise Massey

Research outputs 2022 to 2026

Mixed methodology continues to grow as a rigorous and respected research design. However, the value of qualitatively driven mixed methods research within nursing is underrepresented. Qualitatively driven mixed methods, where qualitative data dominate meaning-making, have the potential to capture critical experiential elements pertinent to nursing research while supporting empirical rigour. This methodology paper argues for the importance of qualitatively driven mixed methods approaches within nursing research to enable greater understanding of complex phenomenon. Through discussion and case example the role of qualitatively driven mixed methods, including within a sequential explanatory design, are presented. Nurses and midwives are well placed to …

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An Exploratory Survey Of The Application Of Accentuated Eccentric Loading In Resistance Training, Jiahao Yang, Comfort, Kristina Kendall, G. Gregory Haff Jan 2026

An Exploratory Survey Of The Application Of Accentuated Eccentric Loading In Resistance Training, Jiahao Yang, Comfort, Kristina Kendall, G. Gregory Haff

Research outputs 2022 to 2026

The aim of this study was to investigate how accentuated eccentric loading (AEL) is currently utilised by strength and conditioning (S&C) coaches. The survey consisted of closed- and open-ended questions divided into 3 key areas of focus (1-Coach and Athlete Demographic, 2-Perceptions of AEL, and 3-Program Design) was administered to S&C coaches. Response frequencies for sections 1 and 2 were calculated as percentages of total respondents, whereas frequencies in Section 3 were calculated relative to respondents who selected each specific training purpose. A thematic analysis was conducted for the responses to an open-ended question. A total of 38 respondents met …

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The Nurse's Role In Curative-To-Palliative Transitions In Advanced Cancer: A Theory Synthesis Using Turner's Method, Geya George, Deborah Kirk, Davina Porock Jan 2026

The Nurse's Role In Curative-To-Palliative Transitions In Advanced Cancer: A Theory Synthesis Using Turner's Method, Geya George, Deborah Kirk, Davina Porock

Research outputs 2022 to 2026

Aim: This paper aims to explain the process of formulating a robust theory that comprehensively explains the nurse's role during the transition from curative to the palliative phase in advanced cancer care. Design: A qualitative theory synthesis approach was applied, utilising Turner's 9-step theory synthesis method to integrate five grounded theories and 10 qualitative studies. The Walker and Avant method of concept development and analysis further ensured rigour. Methods: Turner's theory synthesis was used to formulate a more comprehensive, testable theory from five existing grounded theories and 10 other qualitative studies that explain the nurse's role in supporting and facilitating …

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Co-Design Of An Online Mindfulness Program For Informal Carers Of People Living With Dementia: A Qualitative Study Of Co-Designers’ Experience, Charunya A.K.R. Abeysinghe Mudiyanselage, Seng Giap Marcus Ang, Aisling Smyth, Joanne M. Dickson, Beverley Ewens Jan 2026

Co-Design Of An Online Mindfulness Program For Informal Carers Of People Living With Dementia: A Qualitative Study Of Co-Designers’ Experience, Charunya A.K.R. Abeysinghe Mudiyanselage, Seng Giap Marcus Ang, Aisling Smyth, Joanne M. Dickson, Beverley Ewens

Research outputs 2022 to 2026

Introduction: Informal carers face significant challenges related to care provision for people living with dementia. Participating in a mindfulness-based stress reduction program could improve the wellbeing of informal carers. However, engaging in these programs can be difficult for informal carers due to the needs of their care recipients. Purpose: This study aimed to co-design an online mindfulness program in collaboration with a range of stakeholders and those with lived experience as carers. Methods: This co-design study adopted an interpretive descriptive qualitative approach to the development of the program. The stakeholders (co-designers) included people with lived experience as informal carers and …

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National Consensus On The Capabilities That Inform The Role Of Advanced Practice Paramedics: A Delphi Study, Alessia Restiglian, Lorna Martin, David Long, Louise Reynolds, Tony Walker, Ben Meadley, Ashleigh Finn, Alan Batt, Alecka Miles, Tania Johnston, Brendan Shannon Jan 2026

National Consensus On The Capabilities That Inform The Role Of Advanced Practice Paramedics: A Delphi Study, Alessia Restiglian, Lorna Martin, David Long, Louise Reynolds, Tony Walker, Ben Meadley, Ashleigh Finn, Alan Batt, Alecka Miles, Tania Johnston, Brendan Shannon

Research outputs 2022 to 2026

Advanced Practice Paramedics (APPs) are highly skilled paramedics who operate in diverse clinical settings both within and outside traditional ambulance services. International evidence demonstrates that APPs enhance patient outcomes in areas such as critical and primary care. In Australia, the expansion of APP roles and responsibilities has gained momentum; however, no nationally recognised framework exists to define their expected capabilities. This gap leads to inconsistencies in education, practice and role clarity. A standardised capability framework is therefore vital to guide the development, implementation and integration of APP roles within the Australian healthcare system. The primary aim of this study was …

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Clinician-Led, Single-Blind, Randomised Controlled Trial Evaluating The Efficacy Of A High-Intensity Resistance And Impact Training Intervention For Improving Health-Related Quality Of Life In People With Multiple Sclerosis: Protocol For Strong-Ms, Lisa Grech, Beck, David Scott, Marc Sim, Jakub Mesinovic, Paul Jansons, Fernanda Rodrigues Fonseca, Julie Abimanyi-Ochom, Michelle Allan, Stefan Blum, Ernest Butler, William Carroll, Nigel Caswell, Peter Ebeling, Vanessa Gan, Alan Herschtal, Nevin John, Allan Kermode, Linh Le-Kavanagh, Shalika Bohingamu Mudiyanselage, Lynne Elizabeth Ohman, Mia Poposka, Alison Reece, Phoebe Sansom, Charlotte Scroggie, Christopher Todaro Jan 2026

Clinician-Led, Single-Blind, Randomised Controlled Trial Evaluating The Efficacy Of A High-Intensity Resistance And Impact Training Intervention For Improving Health-Related Quality Of Life In People With Multiple Sclerosis: Protocol For Strong-Ms, Lisa Grech, Beck, David Scott, Marc Sim, Jakub Mesinovic, Paul Jansons, Fernanda Rodrigues Fonseca, Julie Abimanyi-Ochom, Michelle Allan, Stefan Blum, Ernest Butler, William Carroll, Nigel Caswell, Peter Ebeling, Vanessa Gan, Alan Herschtal, Nevin John, Allan Kermode, Linh Le-Kavanagh, Shalika Bohingamu Mudiyanselage, Lynne Elizabeth Ohman, Mia Poposka, Alison Reece, Phoebe Sansom, Charlotte Scroggie, Christopher Todaro

Research outputs 2022 to 2026

Introduction: People with multiple sclerosis (MS) engage in less physical activity and experience higher rates of osteoporosis, falls and fractures than the general population, contributing to reduced health-related quality of life (HRQoL) and increased healthcare costs. High-intensity resistance and impact training (HiRIT) has beneficial effects on bone, muscle and physical function in other populations, but its effectiveness in people with MS is unclear. Methods and analysis: STRONG-MS is a codesigned, clinician-led, single-blind, randomised controlled trial evaluating the effect of a HiRIT programme, ONERO, on HRQoL for people with MS. Secondary aims include assessing changes in bone mineral density, body composition, …

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Feasibility And Preliminary Efficacy Of Integrative Neuromuscular Training For Childhood Cancer Survivors: A Pilot Study, Anna Maria Markarian, U. Newton, Dennis Taaffe, Nicholas G. Gottardo, Santosh Valvi, Carolyn J. Peddle-Mcintyre, Jodie Cochrane Wilkie, Daniel A. Galvão Jan 2026

Feasibility And Preliminary Efficacy Of Integrative Neuromuscular Training For Childhood Cancer Survivors: A Pilot Study, Anna Maria Markarian, U. Newton, Dennis Taaffe, Nicholas G. Gottardo, Santosh Valvi, Carolyn J. Peddle-Mcintyre, Jodie Cochrane Wilkie, Daniel A. Galvão

Research outputs 2022 to 2026

Background: Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long-term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during critical developmental periods. Methods: Eight children treated for ALL (aged 6–12 years) completed a supervised INT intervention (2 sessions/week for 8 weeks). Primary outcomes were feasibility (recruitment, retention, adherence, compliance, and tolerance) and program acceptability. Secondary outcomes included muscle function (isometric midthigh pull [IMTP], countermovement jump, and handgrip strength), dual-energy x-ray absorptiometry (DXA)-derived body composition, peripheral quantitative computed …

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Flourishing In Hong Kong: An Analysis Of Wellbeing-Related Outcomes In The Global Flourishing Study, Lanxi Huang, Xu, Maggie Yue Zhao, Hanchao Hou, Aaron Jarden, Tim Lomas, Brendan Case, R. Noah Padgett, Ying Chen, Richard G. Cowden, Byron R. Johnson, Tyler J. Vanderweele Jan 2026

Flourishing In Hong Kong: An Analysis Of Wellbeing-Related Outcomes In The Global Flourishing Study, Lanxi Huang, Xu, Maggie Yue Zhao, Hanchao Hou, Aaron Jarden, Tim Lomas, Brendan Case, R. Noah Padgett, Ying Chen, Richard G. Cowden, Byron R. Johnson, Tyler J. Vanderweele

Research outputs 2022 to 2026

Using population-based data from Hong Kong (N = 3,012) drawn from Wave 1 of the Global Flourishing Study, this study examines the distribution of multidimensional flourishing and explores sociodemographic variation across psychological, social, physical, and economic domains. Overall, respondents reported relatively strong happiness and life satisfaction and financial wellbeing, alongside less favourable social connectedness. Patterns of flourishing varied across age, gender, education, employment, and religious affiliation, highlighting meaningful heterogeneity within the population. Early older adults tended to show more favourable wellbeing profiles, whereas younger adults and nonreligious individuals displayed comparatively lower scores across several domains. Educational attainment and employment status …

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Multidimensional Sleep Health And Sleep Environment Factors In Individuals With Cancer Undergoing Outpatient Chemotherapy: An Exploratory Cross-Sectional Analysis, Sam Adams, D. Clay, Arman Hasani, Mitchell Turner, Travis Cruickshank Jan 2026

Multidimensional Sleep Health And Sleep Environment Factors In Individuals With Cancer Undergoing Outpatient Chemotherapy: An Exploratory Cross-Sectional Analysis, Sam Adams, D. Clay, Arman Hasani, Mitchell Turner, Travis Cruickshank

Research outputs 2022 to 2026

Purpose: Sleep problems are common amongst individuals with cancer receiving chemotherapy and are associated with poorer health outcomes. Considerable research to date has investigated specific sleep domains or symptomology, with little attention given to overall sleep health, which is more closely associated with overall health. This exploratory cross-sectional study aimed to characterize multidimensional sleep health in individuals with cancer reporting sleep complaints whilst undergoing chemotherapy, with exploratory examination of environmental associations. Patients and Methods: Twenty-three participants were included in this exploratory cross-sectional analysis. Participants were diagnosed with cancer within the last 6 months, undergoing outpatient chemotherapy at time of study …

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Patient-Reported Measures In Children And Adolescents With Chronic Kidney Disease And Their Validation: A Scoping Review, Angela Rejuso, Asif, Martin Howell, Chandana Guha, Siah Kim, Allison Jaure, Anastasia Hughes, Kristy Nicholl, Kylie Ann Mallit, Farzaneh Bouroumad, Jonathan Craig, Armando Teixeira-Pinto, Anna Francis, Nicholas Larkins, Anita Van Zwieten, Germaine Wong Jan 2026

Patient-Reported Measures In Children And Adolescents With Chronic Kidney Disease And Their Validation: A Scoping Review, Angela Rejuso, Asif, Martin Howell, Chandana Guha, Siah Kim, Allison Jaure, Anastasia Hughes, Kristy Nicholl, Kylie Ann Mallit, Farzaneh Bouroumad, Jonathan Craig, Armando Teixeira-Pinto, Anna Francis, Nicholas Larkins, Anita Van Zwieten, Germaine Wong

Research outputs 2022 to 2026

Context: Children with chronic kidney disease (CKD) experience complex challenges affecting their physical, emotional and quality of life outcomes. Patient-reported outcome measures (PROMs) and experience measures (PREMs), collectively known as patient-reported measures (PRMs) are essential to capture these impacts, but their validation and suitability in pediatric CKD research remain underexplored. Objective: To identify and evaluate the psychometric properties of PRMs used in research in children with CKD. Data sources: Medline, Embase, CINAHL and PSYCinfo searched from inception to March 2025. Study selection: Studies that reported the results of at least one PRM completed by patients or proxies in children aged …

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Periodontitis During Pregnancy: The Effect On The Gut Microbiome And Intestinal Inflammation, Richard Bright, G. Macowan, Keyuan Tian, Tracy Fitzsimmons, Rebecca L. Wilson, Claire T. Roberts, Claus T. Christophersen, Peter M. Bartold, Stephen P. Kidd, Peter S. Zilm Jan 2026

Periodontitis During Pregnancy: The Effect On The Gut Microbiome And Intestinal Inflammation, Richard Bright, G. Macowan, Keyuan Tian, Tracy Fitzsimmons, Rebecca L. Wilson, Claire T. Roberts, Claus T. Christophersen, Peter M. Bartold, Stephen P. Kidd, Peter S. Zilm

Research outputs 2022 to 2026

Background: Periodontitis has been epidemiologically associated with adverse pregnancy outcomes, but causality remains difficult to establish in humans due to confounding factors. This study uses a controlled murine model to examine the effects of experimentally induced periodontitis on the composition of the gut microbiota and gastrointestinal inflammation during pregnancy. Methods: Periodontitis was induced in pregnant BALB/c mice via oral inoculation with Porphyromonas gingivalis and Fusobacterium nucleatum before conception (n = 20 per group). Pregnancy outcomes, gut histology, systemic inflammatory markers, and microbiome composition, assessed by 16S rRNA sequencing, were evaluated at gestational Day 18. Results: Periodontitis was confirmed by significant …

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Social Threat, Negative Beliefs, And Altered Social Learning Underpin Paranoia In Adolescents, Jessica L. Kingston, Ellett, Linda Richards, Henry Burgess, Joseph M. Barnby Jan 2026

Social Threat, Negative Beliefs, And Altered Social Learning Underpin Paranoia In Adolescents, Jessica L. Kingston, Ellett, Linda Richards, Henry Burgess, Joseph M. Barnby

Research outputs 2022 to 2026

Adolescent social adversity (discrimination, bullying) enhances paranoia—the perception others want to harm or upset you. In this preregistered study (AsPredicted No. 154322), we tested the impact of prior social adversity and current social exclusion on paranoia, self/other beliefs, and latent social-learning processes in UK mid-adolescents (15-17 years, N = 502). In an experimental design, participants completed baseline social-adversity measures before random allocation to a social inclusion/exclusion manipulation (Cyberball), after which the Intentions Game assessed cognitive flexibility. We tested (a) whether adversity and exclusion interact to increase paranoia (b) via (mediated) negative self/other beliefs and (c) if this was moderated by …

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The Associations Between Sleep Environment Factors And Sleep Health In Individuals Living With Neurological Conditions, Mitchell Turner, Laws, Madeline Griffiths, Travis Cruickshank Jan 2026

The Associations Between Sleep Environment Factors And Sleep Health In Individuals Living With Neurological Conditions, Mitchell Turner, Laws, Madeline Griffiths, Travis Cruickshank

Research outputs 2022 to 2026

Objectives: To explore associations between air temperature and light in the sleeping environment and sleep health in individuals with neurological conditions. Methods: The sleep health of 46 individuals with neurological conditions (mean age 51.37 ± 14.24 years; 20 males, 26 females) was measured using the Sleep Health Index (SHI). Air temperature and light data were captured across seven days using a light/temperature data logger positioned next to the participant’s bed. Data recorded during the participants’ sleeping periods (determined using a sleep diary) were analyzed. Linear regression models were used to assess the associations between air temperature and light and sleep …

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On Burden Of Diseases, Prevention, Medical Research And Health Service Delivery: Grampian Case Study, Seshadri S. Vasan, Sudarshan Anand, Miae Lee, Nicholas C. Fluck Jan 2026

On Burden Of Diseases, Prevention, Medical Research And Health Service Delivery: Grampian Case Study, Seshadri S. Vasan, Sudarshan Anand, Miae Lee, Nicholas C. Fluck

Research outputs 2022 to 2026

Burden of diseases measured as disability-adjusted life years (DALYs) per 100,000 people can be mined from public domain data, when they are made available by population health surveillance systems. This can be analysed to allow insightful comparisons with the national average, and to understand differences in trends between the sexes, age groups, time periods, geographic regions, and sub-regions. In this illustrative case study, we have analysed the Scottish burden of disease database to understand what ailed the population of the Grampian region before the COVID-19 pandemic. We have identified that selected cancers, ischaemic heart disease, Alzheimer’s disease and other dementias …

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