Medicine and Health Sciences Commons^™

Factors Associated With Family Carers’ Fall Concern: Prospective Study Protocol, Seng Giap Marcus Ang, Rosemary Saunders, Chiew Jiat Rosalind Siah, Charlotte Foskett, Christopher Etherton-Beer, Karen Gullick, Melissa Dunham, Nicolette Sagaram, Rhea Rodriguez Tecson, Sue Haydon, Amanda Wilson

Research outputs 2022 to 2026

Background: Family carers are important in preventing community-dwelling older people from falling. Family carers’ concerns about older people's risk of falling could affect their own physical and psychological health, lifestyle, and burden of care. While there are many studies exploring factors associated with fear of falling among older people, there is no research on family carers’ fall concern of older people (care recipients) who are hospitalised. Aim: This paper describes a prospective study protocol exploring the relationship of fall concern, psychological distress, and quality of life of family carers when their care recipient is hospitalised and after discharge. Methods: The …

Igg N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age, Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang

Research outputs 2022 to 2026

The use of an altered immunoglobulin G (IgG) N-glycan pattern as an inflammation metric has been reported in subclinical atherosclerosis and metabolic disorders, both of which are important risk factors in cardiovascular health. However, the usable capacity of IgG N-glycosylation profiles for the risk stratification of cardiovascular diseases (CVDs) remains unknown. This study aimed to develop a cardiovascular aging index for tracking cardiovascular risk using IgG N-glycans. This cross-sectional investigation enrolled 1465 individuals aged 40–70 years from the Busselton Healthy and Ageing Study. We stepwise selected the intersection of altered N-glycans using feature-selection methods in machine learning (recursive feature elimination …

Models Of Clinical Supervision Of Relevance To Remote Area Nursing & Primary Health Care: A Scoping Review, Fiona Hildebrand, Michelle Gray, Kylie Mccullough

Research outputs 2022 to 2026

Introduction: Nurses in remote primary health care settings work in difficult conditions, in isolated and disadvantaged communities, and often must work beyond their scope to provide advanced assessments and treatments to support the community. Therefore, remote area nurses require support to develop their skills and knowledge to work safely within their full scope of practice. Clinical supervision is widely used in health professions for this purpose; however, models of supervision for nursing have not been implemented or evaluated within remote primary health care settings. Objective: The purpose of this study was to search the literature to source suitable clinical supervision …

Periodic Changes In The N-Glycosylation Of Immunoglobulin G During The Menstrual Cycle, Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc

Research outputs 2022 to 2026

Immunoglobulin G (IgG) is the most abundant plasma glycoprotein and a prominent humoral immune mediator. Glycan composition affects the affinity of IgG to ligands and consequent immune responses. The modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sex hormones modulate the immune system. Although the menstrual cycle is the central sex hormone-related physiological process in most women of reproductive age, IgG N-glycosylation dynamics during the menstrual cycle have not yet been investigated. To fill this gap, we profiled the plasma IgG N-glycans of 70 healthy premenopausal women at 12 time points during their …

Perturbation Of 3d Nuclear Architecture, Epigenomic Dysregulation And Aging, And Cannabinoid Synaptopathy Reconfigures Conceptualization Of Cannabinoid Pathophysiology: Part 1–Aging And Epigenomics, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Much recent attention has been directed toward the spatial organization of the cell nucleus and the manner in which three-dimensional topologically associated domains and transcription factories are epigenetically coordinated to precisely bring enhancers into close proximity with promoters to control gene expression. Twenty lines of evidence robustly implicate cannabinoid exposure with accelerated organismal and cellular aging. Aging has recently been shown to be caused by increased DNA breaks. These breaks rearrange and maldistribute the epigenomic machinery to weaken and reverse cellular differentiation, cause genome-wide DNA demethylation, reduce gene transcription, and lead to the inhibition of developmental pathways, which contribute to …

Prednisolone For Copd Exacerbations: Time For A Rethink, Sanjay Ramakrishnan

Research outputs 2022 to 2026

Prednisolone given universally for COPD exacerbations causes harm without any benefit. Patients deserve blood eosinophil-guided prednisolone treatment for COPD exacerbations.

Rural Nutrition And Dietetics Research—Future Directions, Laura Alston, Susan Heaney, Katherine Kent, Stephanie Godrich, Lucy Kocanda, Jaimee Herbert, Tracy Schumacher, Leanne J. Brown

Research outputs 2022 to 2026

Aim: The aim of this study was to summarise key evidence from recent Australian rural nutrition research and provide recommendations for future nutrition and dietetics research with rural communities. Context: Clear evidence demonstrates that diet plays a role in the health gap between rural and metropolitan Australia. Despite the opportunity to address the health of rural Australians through better nutrition, alarmingly low investment in nutrition and dietetics research has occurred historically, and over the past decade. Approach: A review of the evidence was undertaken by rural nutrition and dietetics leaders to provide a commentary piece to inform future rural nutrition …

Systemic Treatment Of Advanced And Metastatic Urothelial Cancer: The Landscape In Australia, Howard Gurney, Timothy D. Clay, Niara Oliveira, Shirley Wong, Ben Tran, Carole Harris

Research outputs 2022 to 2026

The 5-year survival rate of metastatic urothelial carcinoma (mUC) is estimated to be as low as 5%. Currently, systemic platinum-based chemotherapy followed by avelumab maintenance therapy is the only first-line treatment for mUC that has an overall survival benefit. Cisplatin-based chemotherapy (usually in combination with gemcitabine) is the preferred treatment but carboplatin is substituted where contraindications to cisplatin exist. Treatment with immune checkpoint inhibitors, antibody-drug conjugates, and kinase inhibitors has not yet demonstrated superiority to chemotherapy as first-line therapy and remains investigational in this setting. A recent media release indicates that chemotherapy plus nivolumab gives an OS advantage as first-line …

Thyroid Dysfunction And Glycaemic Control Among Type 2 Diabetes Mellitus Patients In Ghana: A Comparative Cross-Sectional Study, Samuel Asamoah Sakyi, Bright Ameyaw, Edwin Ferguson Laing, Richard Anthony, Richard K.Dadzie Ephraim, Alfred Effah, Afia Agyapomaa Kwayie, Ebenezer Senu, Enoch Odame Anto, Emmanuel Acheampong, Bright Oppong Afranie, Benjamin Amoani, Stephen Opoku

Research outputs 2022 to 2026

Introduction: Thyroid disorders and diabetes mellitus coexist and are prevalent endocrinopathies among adult population. Thyroid dysfunction contributes to metabolic imbalances, increase beta-cell apoptosis and glucose intolerance. There is paucity of data and contradicting findings on how thyroid dysfunction influence glycaemic control. Therefore, we evaluated thyroid dysfunction and glycaemic control among Type 2 diabetes mellitus (T2DM) patients in Ghana. Methods: A comparative cross-sectional study was conducted among 192 T2DM patients from Effia Nkwanta Regional Hospital. Three consecutive monthly fasting plasma glucose (FBG) and glycated haemoglobin (HbA1c) were analysed and the results were classified as, moderate hyperglycaemia (MH) (FBG = 6.1–12.0 mmol/L, …

What Is Known About Midwives' Well-Being And Resilience? An Integrative Review Of The International Literature, Lynnelle Moran, Kim Foster, Sara Bayes

Research outputs 2022 to 2026

Background: Internationally, the midwifery workforce is facing a professional crisis due to numerous organizational and individual factors that have led to midwives leaving the profession. These factors include high levels of workplace stress, systemic barriers to providing woman and person-centered care, trauma, and burnout. The COVID-19 pandemic magnified these pre-existing stressors and adversities and has further disrupted midwives' ability to practice within their professional norms. In order to understand how midwives can be better supported, there is a need to understand what contributes to and detracts from their well-being and resilience. Aim: To investigate and synthesize the extant international knowledge …

The Burden Of Self-Reported Antibiotic Allergies In Health Care And How To Address It: A Systematic Review Of The Evidence, Annabelle Arnold, Linda L. Coventry, Mandie Foster, Jennifer J. Koplin, Michaela Lucas

Research outputs 2022 to 2026

Background: Antibiotics are the first-line treatment for bacterial infections; however, overuse and inappropriate prescribing have made antibiotics less effective with increased antimicrobial resistance. Unconfirmed reported antibiotic allergy labels create a significant barrier to optimal antimicrobial stewardship in health care, with clinical and economic implications. Objective: A systematic review was conducted to summarize the impact of patient-reported antibiotic allergy on clinical outcomes and various strategies that have been employed to effectively assess and remove these allergy labels, improving patient care. Methods: The review was undertaken using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A critical appraisal was conducted …

Barry Turner: The Under-Acknowledged Safety Pioneer, Kym Bills, Leesa N. Costello, Marcus Cattani

Research outputs 2022 to 2026

Barry Turner’s 1978 Man-made Disasters and Charles Perrow’s 1984 Normal Accidents were seminal books but a detailed comparison has yet to be undertaken. Doing so is important to establish content and priority of key ideas underpinning contemporary safety science. Turner’s research found socio-technical and systemic patterns that meant that major organisational disasters could be foreseen and were preventable. Perrow’s macro-structuralist industry focus was on technologically deterministic but unpredictable and unpreventable “system” accidents, particularly rare catastrophes. Andrew Hopkins and Nick Pidgeon respectively suggested that some prominent writers who wrote after Turner may not have been aware of, or did not properly …

Dementia Care For People From Culturally And Linguistically Diverse Backgrounds: Qualitative Secondary Analysis Of The Aged Care Australian Royal Commission Data, Pelden Chejor, Patricia Cain, Bridget Laging, Davina Porock

Research outputs 2022 to 2026

Objective:

Understanding the concerns and experiences of people living with dementia from culturally and linguistically diverse backgrounds is critical to ensure culturally appropriate care is delivered. This study aimed to describe the current experiences and concerns of older people from culturally and linguistically diverse backgrounds using the publicly available evidence from the Australian Royal Commission into Aged Care Quality and Safety.

Methods:

This was a qualitative secondary analysis of the Australian Royal Commission into Aged Care Quality and Safety data to explore new and nuanced insights about care for culturally and linguistically diverse people living with dementia. Using the keywords …

Aversive Reaction Between Disulfiram And Betel Quid Among Inpatients With Alcohol Use Disorder In Bhutan: A Preliminary Study, Ugyen Dem, Zimba Letho, Chencho Dorji, Damber K. Nirola, Sonam Choki, Tashi Dorji, Pelden Chejor

Research outputs 2022 to 2026

Betel Quid (BQ) is commonly used in the Asia-Pacific region. Disulfiram is prescribed for people with alcohol use disorders (PwAUDs) after the completion of detoxification as an alternative to rehabilitation. This prospective observational study reports the aversive reactions and common symptoms of Disulfiram and BQ in PwAUDs. Participants included PwAUDs admitted to the psychiatric ward at the Jigme Dorji Wangchuck National Referral Hospital for detoxification, who were on Disulfiram and using BQ at the same time. Aversive reactions between Disulfiram and BQ were observed for 100 patients over a year. Twenty participants showed aversive reactions between BQ and Disulfiram. Common …

Associations Of Physical Activity And Quality Of Life In Parapneumonic Effusion Patients, Pedro Lopez, Deirdre B. Fitzgerald, Joanne A. Mcveigh, Arash Badiei, Sanjeevan Muruganandan, Robert U. Newton, Leon Straker, Yun C. G. Lee, Carolyn J. Peddle-Mcintyre

Research outputs 2022 to 2026

Introduction Little is known about activity behaviours and quality of life (QoL) of patients with parapneumonic pleural effusions (PPE) after hospital discharge. This study is a secondary analysis of a randomised trial (dexamethasone versus placebo) for hospitalised patients with PPE. We: 1) described the patients’ activity behaviour patterns and QoL measured at discharge and at 30 days post-discharge; and 2) examined the association between activity behaviours and QoL scores. Methods Activity behaviour (7-day accelerometry; Actigraph GT3X+) and QoL (Medical Outcomes Study Short-Form 36) were assessed. Repeated measures analysis of covariance controlling for baseline values and a series of linear regression …

Bidirectional Causality Between Immunoglobulin G N-Glycosylation And Metabolic Traits: A Mendelian Randomization Study, Xiaoni Meng, Weijie Cao, Di Liu, Isinta M. Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang

Research outputs 2022 to 2026

Although the association between immunoglobulin G (IgG) N-glycosylation and metabolic traits has been previously identified, the causal association between them remains unclear. In this work, we used Mendelian randomization (MR) analysis to integrate genome-wide association studies (GWASs) and quantitative trait loci (QTLs) data in order to investigate the bidirectional causal association of IgG N-glycosylation with metabolic traits. In the forward MR analysis, 59 (including nine putatively causal glycan peaks (GPs) for body mass index (BMI) (GP1, GP6, etc.) and seven for fasting plasma glucose (FPG) (GP1, GP5, etc.)) and 15 (including five putatively causal GPs for BMI (GP2, GP11, etc.) …

Coagulation Factors And Natural Anticoagulants As Surrogate Markers Of Preeclampsia And Its Subtypes: A Case-Control Study In A Ghanaian Population, Selina Mintaah, Enoch O. Anto, Wina I. O. Boadu, Benedict Sackey, Lily A. Boateng, Ezekiel Ansah, Emmanuel E. Korsah, Joseph Frimpong, Valentine C. K. T. Tamakloe, Peter K. Selleh, David A. Afrifa, Abdul-Razak Saasi, Ebenezer Senu, Lawrence A. Duah, Stephen Opoku, John P. Amoah, Patrick Adu, Joseph Boachie, Dorcas A. Nyamekye, David S. Sackey, Yaw A. Wiafe, Otchere Addai-Mensah

Research outputs 2022 to 2026

Preeclampsia (PE) is associated with endothelial injury and hemostatic abnormalities. However, the diagnostic role of coagulation parameters and natural anticoagulants in predicting PE has not been explored in Ghana. This study assessed plasma levels of these factors as surrogate markers of PE and its subtypes. This case-control study included 90 women with PE (cases) and 90 normotensive pregnant women (controls). Blood samples were drawn for the estimation of complete blood count and coagulation tests. The prothrombin time (PT), activated partial thromboplastin time (APTT), and the calculation of the international normalized ratio (INR) were determined by an ACL elite coagulometer while …

Longitudinal Trajectories Of Basal Forebrain Volume In Normal Aging And Alzheimer's Disease, Ying Xia, Paul Maruff, Vincent Doré, Pierrick Bourgeat, Simon M. Laws, Christopher Fowler, Stephanie R. Rainey-Smith, Ralph N. Martins, Victor L. Villemagne, Christopher C. Rowe, Colin L. Masters, Elizabeth J. Coulson, Jurgen Fripp

Research outputs 2022 to 2026

Dysfunction of the cholinergic basal forebrain (BF) system and amyloid- (A ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed A -PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and A status (A −, A +). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high A …

Relieving The Gambling Itch Through Alcohol Consumption: The Impact Of Covid-19 Restrictions On Australian Casino Patrons, Tenghao Zhang, Pi-Shen Seet, Janice Redmond, Jalleh Sharafizad

Research outputs 2022 to 2026

This paper extends our understanding of how casino patrons are affected by COVID-19 restrictions and how they cope by substituting gambling with alcohol consumption. We conducted two studies using a nationwide survey sample collected in Australia during the pandemic lockdown. Study 1 compares the casino patrons with two reference groups (other gambling patrons and non-gambling individuals) and investigates the lockdown restrictions on respondents’ relational strength, and their potential impact on mental health and future prospects. Study 2 applies the stress-response dampening model (SRD) and tests how respondents used alcohol consumption to cope with the lack of access to casinos during …

Testing Campaign Slogans Designed To Motivate Older People To Be More Physically Active, Simone Pettigrew, Michelle I. Jongenelis, Liyuwork M. Dana, Rajni Rai, Ben Jackson, Robert U. Newton

Research outputs 2022 to 2026

Objectives and importance of study: Being physically active is critical for healthy ageing, yet many older people do not meet physical activity guidelines. The aim of this study was to test the relative effectiveness of five previously identified campaign slogans designed to encourage older people to be more physically active: ‘Be active 30–60 minutes a day to stay fit and well’; ‘Move more, live longer’; ‘Stay fit to stay functional’; ‘This is your time – enjoy being strong and active’; and ‘Use it or lose it’. Study type: Online experiment Methods: A total of 1200 Australians aged 50 years and …

Comparing Clinico-Demographics And Neuropsychiatric Symptoms For Immigrant And Non-Immigrant Aged Care Residents Living With Dementia: A Retrospective Cross-Sectional Study From An Australian Dementia-Specific Support Service, Pelden Chejor, Mustafa Atee, Patricia Cain, Daniel Whiting, Thomas Morris, Davina Porock

Research outputs 2022 to 2026

Background:

Neuropsychiatric symptoms of dementia such as agitation and aggression are common in people living with dementia. The presentation of neuropsychiatric symptoms is influenced by the cultural background of people living with dementia. Further, identifying factors contributing to neuropsychiatric symptoms may be complicated if people living with dementia are immigrants or from non-English-speaking backgrounds. Most of what is known about differences in neuropsychiatric symptoms between racial and ethnic groups living with dementia come from community-based samples. This study investigated differences in clinico-demographics and neuropsychiatric symptoms between immigrants and non-immigrants living with dementia in residential aged care homes who were referred …

Relationship Between Dietary Intake And Erythrocyte Pufa In Adolescents From A Western Australian Cohort, Fuzhen Wan, Feng Pan, Trevor A. Mori, Therese A. O’Sullivan, Lawrence J. Beilin, Wendy H. Oddy

Research outputs 2022 to 2026

Background:

Population-based studies show that the intake of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) are associated with a range of health conditions. Therefore, the reliability of food frequency questionnaires (FFQ) as rapid and easily accessible screening tools for PUFA intake deserve investigation.

Objective:

We aimed to assess the relationship between erythrocyte fatty acids and fatty acid intake collected using the Commonwealth Scientific and Industrial Research Organisation (CSIRO) food frequency questionnaire in an adolescent cohort.

Design:

A cross-sectional study using data from 1155 young adolescents participating in the 14-year follow-up of the Raine Study. Bland–Altman plots were used …

The Impact Of Sleep-Wake Behaviour On Tennis Match Performance In Junior State Grade Tennis Players, Mitchell Turner, Philipp Beranek, Ian Dunican, Travis Cruickshank

Research outputs 2022 to 2026

Purpose:

To date, no study has investigated the extent to which sleep-wake behaviour (SWB) influences match performance in junior tennis players. This study aimed to assess the influence of SWB for the week and night before on match performance, particularly match analytics and activity.

Methods:

This study recruited 10 junior state grade tennis players who wore an actigraphy device and completed a sleep diary for the week before their match on two separate occasions throughout their competition season. Players wore a global positioning system device to track their movement during matches, and an experienced tennis coach recorded players' match analytics. …

Integrated Clinical Pathways For Lower Limb Orthopaedic Surgeries: An Updated Systematic Review, Huaqiong Zhou, Irene M. Ngune, Pam Roberts, Phillip Della

Research outputs 2022 to 2026

Objective

The objective of the study was to comprehensively synthesise the components of integrated clinical pathways (ICPs) and post-operative outcomes of patients undergone total hip and knee arthroplasty (THA & TKA) and hip fracture surgeries.

Background

Previous systematic reviews examined components and effectiveness of ICPs for lower limb joint replacement and hip fracture surgeries.

Design and Methods

An updated systematic review guided by the Whittemore and Knafl (2005) framework. Electronic databases, Ovid MEDLINE, EBSCOhost-CINAHL, the Cochrane Reviews and Trails, EMBASE and PubMed, were searched from 2007 to 31 January 2021. Due to the heterogeneity of the methods and data collection …

Injury Profiles Of Police Recruits Undergoing Basic Physical Training: A Prospective Cohort Study, Nicole Merrick, Nicolas H. Hart, Andrea B. Mosler, Garth Allen, Myles C. Murphy

Research outputs 2022 to 2026

Purpose:

A lack of published epidemiological data among police recruits presents a major challenge when designing appropriate prevention programs to reduce injury burden. We aimed to report the injury epidemiology of Western Australian (WA) Police Force recruits and examine sex and age as injury risk factors

Methods:

Retrospective analyses were conducted of prospectively collected injury data from WA Police Force recruits between 2018–2021. Injury was defined as ‘time-loss’ and injury incidence rate per 1000 training days (Poisson exact 95% confidence intervals) was calculated. For each region and type of injury, the incidence, severity, and burden were calculated. The association between …

Autonomy Versus Support: Self-Reliance And Help-Seeking For Mental Health Problems In Young People, Amelia Ishikawa, Debra Rickwood, Emily Bariola, Navjot Bhullar

Research outputs 2022 to 2026

Purpose:

Many young people with mental ill-health do not seek support, and developmental growth in self-reliance may be a barrier to help-seeking. Increasing autonomy is a positive developmental task for youth and a key aspect of resilience. This study examined the influence of perceived social support and resilience on the previously unexamined relationship between self-reliance and intentions to seek help from informal, professional, and self-help sources for mental health problems.

Methods:

An online survey was completed by a representative Australian community sample of 5,203 young people aged 12–25 years (half female), in May–June 2020.

Results:

Path analysis showed the hypothesised …

The Impact Of Acute Calcium Intake On Bone Turnover Markers During A Training Day In Elite Male Rowers, Bronwen Lundy, Alannah K. A. Mckay, Nikita C. Fensham, Fensham, Nicolin Tee, Bryce Anderson, Aimee Morabito, Megan L. R. Ross, Marc Sim, Kathryn Ackerman, Louise M. Burke

Research outputs 2022 to 2026

Introduction: While an acute exercise session typically increases bone turnover markers (BTM), the impact of subsequent sessions and the interaction with pre-exercise calcium intake remains unclear despite the application to the ‘real life’ training of many competitive athletes. Methods: Using a randomized crossover design, elite male rowers (n = 16) completed two trials, a week apart, consisting of two 90-minute rowing ergometer sessions (Ex1, Ex2) separated by 150 minutes. Prior to each trial, participants consumed a high (CAL: ~1000 mg) or isocaloric low (CON: < 10 mg) calcium meal. Biochemical markers including parathyroid hormone: PTH; serum ionised calcium (iCa) and bone turnover markers (C-terminal telopeptide of type I collagen: β-CTX-I; osteocalcin: OC) were monitored from baseline to 3 hours post Ex2. Results: While each session caused perturbances of serum iCa, CAL maintained calcium concentrations above those of CON for most time points, 4.5 and 2.4 % higher post EX1 and EX2 respectively. The decrease in iCa in CON was associated with an elevation of blood PTH (p < 0.05) and β-CTX-I (p < 0.0001) over this period of repeated training sessions and their recovery, particularly during and after Ex2. Pre-exercise intake of calcium-rich foods lowered BTM over the course of a day with several training sessions. Conclusions: Pre-exercise intake of a calcium-rich meal prior to training sessions undertaken within the same day had a cumulative and prolonged effect on the stabilisation of blood iCa during exercise. In turn, this reduced the post-exercise PTH response, potentially attenuating the increase in markers of bone resorption. Such practical strategies may be integrated into the athlete’s overall sports nutrition plan, with the potential to safeguard long term bone health and reduce the risk of bone stress injuries.

Exercise Builds The Scaffold Of Life: Muscle Extracellular Matrix Biomarker Responses To Physical Activity, Inactivity, And Aging, Georgios Mavropalias, Marni Boppart, Kayley M. Usher, Miranda D. Grounds, Kazunori Nosaka, Anthony J. Blazevich

Research outputs 2022 to 2026

Skeletal muscle extracellular matrix (ECM) is critical for muscle force production and the regulation of important physiological processes during growth, regeneration, and remodelling. ECM remodelling is a tightly orchestrated process, sensitive to multi-directional tensile and compressive stresses and damaging stimuli, and its assessment can convey important information on rehabilitation effectiveness, injury, and disease. Despite its profound importance, ECM biomarkers are underused in studies examining the effects of exercise, disuse, or aging on muscle function, growth, and structure. This review examines patterns of short- and long-term changes in the synthesis and concentrations of ECM markers in biofluids and tissues, which may …

A Novel Skin Cancer Prevention Strategy: Preservice Teachers' Perceptions Of A Sun Safety Intervention And Experiences In Schools, Joseph J. Scott, Robyn S. Johnston, Jill Darby, Sally Blane, Mark Strickland, Bronwen M. Mcnoe

Research outputs 2022 to 2026

Issue addressed:

Teachers play a vital role in developing children's sun protection routines however upskilling preservice teachers (PSTs) while at university has not yet been trialled as a targeted skin cancer prevention strategy. Hence, this study investigated PSTs perceptions and experiences of sun safety following a brief pilot intervention and placement in primary schools in Western Australia.

Methods:

This study used a triangulation mixed methods design. Participants (n = 161) completed a post intervention survey which was analysed quantitatively. A random sub-sample was invited to participate in focus groups (three groups, n = 21) and one-on-one interviews (n = 4). …

Decoding The Mechanism Of Hypertension Through Multiomics Profiling, Eric Adua

Research outputs 2022 to 2026

Hypertension, characterised by a constant high blood pressure, is the primary risk factor for multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations in high-throughput technologies have enabled the global exploration of the whole genome (genomics), revealing dysregulated genes that are linked to hypertension. Moreover, post-genomic biomarkers, from the emerging fields of transcriptomics, proteomics, glycomics and lipidomics, have provided new insights into the molecular underpinnings of hypertension. In this paper, we review the pathophysiology of hypertension, and highlight the multi-omics approaches for hypertension prediction and diagnosis.