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Articles 181 - 210 of 3619
Full-Text Articles in Medicine and Health Sciences
Exploring Assessment Policies For Clinical Practice: A Scoping Review Of The Literature, Lynda J. Hughes, Amy N. B. Johnston, Jacqueline H. Byrne, Debbie Massey
Exploring Assessment Policies For Clinical Practice: A Scoping Review Of The Literature, Lynda J. Hughes, Amy N. B. Johnston, Jacqueline H. Byrne, Debbie Massey
Research outputs 2022 to 2026
Background: Assessment of pre-registration nursing students in clinical practice is an essential process, ensuring students who graduate meet standards for practice and competently and safely care for patients under their care. However, such assessment remains challenging for individuals and organisations. Aim: We aimed to investigate what is known about the application of clinical placement assessment policies guiding pre-registration nursing programmes. Methods: Arskey and O'Malley’s five-stage method for scoping reviews was employed. Health and education databases were searched in July 2020 and December 2021. Identified papers were screened. The Joanna Briggs Institute's critical appraisal tools were used to appraise the quality …
Cerebrospinal Fluid Proteomics Define The Natural History Of Autosomal Dominant Alzheimer’S Disease, Erik C. B. Johnson, Shijia Bian, Rafi U. Haque, E. Kathleen Carter, Caroline M. Watson, Brian A. Gordon, Lingyan Ping, Duc M. Duong, Michael P. Epstein, Eric Mcdade, Nicolas R. Barthélemy, Celeste M. Karch, Chengjie Xiong, Carlos Cruchaga, Richard J. Perrin, Aliza P. Wingo, Thomas S. Wingo, Jasmeer P. Chhatwal, Gregory S. Day, James M. Noble, Sarah B. Berman, Ralph Martins, Neill R. Graff-Radford, Peter R. Schofield, Takeshi Ikeuchi, Hiroshi Mori, Johannes Levin, Martin Farlow, James J. Lah, Christian Haass, Mathias Jucker, John C. Morris, Tammie L. S. Benzinger, Blaine R. Roberts, Randall J. Bateman, Anne M. Fagan, Nicholas T. Seyfried, Allan I. Levey, Dominantly Inherited Alzheimer Network
Cerebrospinal Fluid Proteomics Define The Natural History Of Autosomal Dominant Alzheimer’S Disease, Erik C. B. Johnson, Shijia Bian, Rafi U. Haque, E. Kathleen Carter, Caroline M. Watson, Brian A. Gordon, Lingyan Ping, Duc M. Duong, Michael P. Epstein, Eric Mcdade, Nicolas R. Barthélemy, Celeste M. Karch, Chengjie Xiong, Carlos Cruchaga, Richard J. Perrin, Aliza P. Wingo, Thomas S. Wingo, Jasmeer P. Chhatwal, Gregory S. Day, James M. Noble, Sarah B. Berman, Ralph Martins, Neill R. Graff-Radford, Peter R. Schofield, Takeshi Ikeuchi, Hiroshi Mori, Johannes Levin, Martin Farlow, James J. Lah, Christian Haass, Mathias Jucker, John C. Morris, Tammie L. S. Benzinger, Blaine R. Roberts, Randall J. Bateman, Anne M. Fagan, Nicholas T. Seyfried, Allan I. Levey, Dominantly Inherited Alzheimer Network
Research outputs 2022 to 2026
Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes—aggregation of the amyloid- (A ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)—are hallmarks of the disease. However, other pathological brain processes are thought to be key disease mediators of A plaque and NFT pathology. How these additional pathologies evolve over the course of the disease is currently unknown. Here we show that proteomic measurements in autosomal dominant AD cerebrospinal fluid (CSF) linked to brain protein coexpression can be used to characterize the evolution of AD pathology over a timescale …
Contrast Detection Is Enhanced By Deterministic, High-Frequency Transcranial Alternating Current Stimulation With Triangle And Sine Waveform, Weronika Potok, Onno Van Der Groen, Sahana Sivachelvam, Marc Bächinger, Flavio Fröhlich, Laszlo B. Kish, Nicole Wenderoth
Contrast Detection Is Enhanced By Deterministic, High-Frequency Transcranial Alternating Current Stimulation With Triangle And Sine Waveform, Weronika Potok, Onno Van Der Groen, Sahana Sivachelvam, Marc Bächinger, Flavio Fröhlich, Laszlo B. Kish, Nicole Wenderoth
Research outputs 2022 to 2026
Stochastic resonance (SR) describes a phenomenon where an additive noise (stochastic carrier-wave) enhances the signal transmission in a nonlinear system. In the nervous system, nonlinear properties are present from the level of single ion channels all the way to perception and appear to support the emergence of SR. For example, SR has been repeatedly demonstrated for visual detection tasks, also by adding noise directly to cortical areas via transcranial random noise stimulation (tRNS). When dealing with nonlinear physical systems, it has been suggested that resonance can be induced not only by adding stochastic signals (i.e., noise) but also by adding …
Nurses’ Education, Knowledge And Perceptions Of Peripheral Intravenous Catheter Management: A Web-Based, Cross-Sectional Survey, Debbie Massey, Marie Cooke, Gillian Ray-Barruel, Nicole Marsh, Amanda J. Ullman, Alison Craswell, Marianne Wallis
Nurses’ Education, Knowledge And Perceptions Of Peripheral Intravenous Catheter Management: A Web-Based, Cross-Sectional Survey, Debbie Massey, Marie Cooke, Gillian Ray-Barruel, Nicole Marsh, Amanda J. Ullman, Alison Craswell, Marianne Wallis
Research outputs 2022 to 2026
Background: Peripheral intravenous catheters (PIVCs) are the most used invasive medical device. Unfortunately, PIVCs fail for a variety of reasons and failure often results in serious adverse events leading to patient discomfort, infection, delays in treatment, increased healthcare costs, and even death. In Australia, qualified nurses assess, manage, and remove a PIVC as part of their clinical role. To date, no study has described the current state of knowledge and confidence (self-efficacy) about PIVCs from the perspectives of qualified nurses working in Australian hospital settings. Aims: To describe the current state of knowledge and confidence (self-efficacy) about PIVC management from …
Proposed Quality Indicators And Recommended Standard Reporting Items In Performance Of Ebus Bronchoscopy: An Official World Association For Bronchology And Interventional Pulmonology Expert Panel Consensus Statement, Daniel P. Steinfort, Matthew Evison, Ashleigh Witt, Georgios Tsaknis, Fayez Kheir, David Manners, Karan Madan, Calvin Sidhu, Alberto Fantin, Daniel A. Korevaar, Erik H. F. M. Van Der Heijden, The Wabip Taskforce On Quality Indicators In Ebus Bronchoscopy
Proposed Quality Indicators And Recommended Standard Reporting Items In Performance Of Ebus Bronchoscopy: An Official World Association For Bronchology And Interventional Pulmonology Expert Panel Consensus Statement, Daniel P. Steinfort, Matthew Evison, Ashleigh Witt, Georgios Tsaknis, Fayez Kheir, David Manners, Karan Madan, Calvin Sidhu, Alberto Fantin, Daniel A. Korevaar, Erik H. F. M. Van Der Heijden, The Wabip Taskforce On Quality Indicators In Ebus Bronchoscopy
Research outputs 2022 to 2026
Background: Since their introduction, both linear and radial endobronchial ultrasound (EBUS) have become an integral component of the practice of Pulmonology and Thoracic Oncology. The quality of health care can be measured by comparing the performance of an individual or a health service with an ideal threshold or benchmark. The taskforce sought to evaluate quality indicators in EBUS bronchoscopy based on clinical relevance/importance and on the basis that observed significant variation in outcomes indicates potential for improvement in health care outcomes. Methods: A comprehensive literature review informed the composition of a comprehensive list of candidate quality indicators in EBUS. A …
Does Gender And Cultural Diversity Matter For Sustainability In Healthcare? Evidence From Global Organizations, Kylie De Klerk, Favil Singh
Does Gender And Cultural Diversity Matter For Sustainability In Healthcare? Evidence From Global Organizations, Kylie De Klerk, Favil Singh
Research outputs 2022 to 2026
Global healthcare organizations are fundamental in addressing the healthcare needs of local and global communities. This highly regulated sector means it is under constant scrutiny for health, safety, and ethical compliance risks by federal regulatory bodies. Despite higher monitoring, an increasing number of healthcare companies receive fines for their irresponsible practices, manifesting significant questions about their corporate governance and sustainability practices. Against this backdrop, this study examines the relationship between boardroom diversity on the sustainability performance of companies operating in healthcare. Utilizing a global sample of publicly listed healthcare companies, using panel regression data and the system-GMM estimator accounting for …
Positron Emission Tomography And Magnetic Resonance Imaging Methods And Datasets Within The Dominantly Inherited Alzheimer Network (Dian), Nicole S. Mckay, Brian A. Gordon, Russ C. Hornbeck, Aylin Dincer, Shaney Flores, Sarah J. Keefe, Nelly Joseph-Mathurin, Clifford R. Jack, Robert Koeppe, Peter R. Millar, Beau M. Ances, Charles D. Chen, Alisha Daniels, Diana A. Hobbs, Kelley Jackson, Deborah Koudelis, Parinaz Massoumzadeh, Austin Mccullough, Michael L. Nickels, Farzaneh Rahmani, Laura Swisher, Qing Wang, Ricardo F. Allegri, Sarah B. Berman, Adam M. Brickman, William S. Brooks, David M. Cash, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Christian La Fougère, Nick C. Fox, Michael Fulham, Bernardino Ghetti, Neill Graff-Radford, Takeshi Ikeuchi, William Klunk, Jae-Hong Lee, Johannes Levin, Ralph Martins, Colin L. Masters, Jonathan Mcconathy, Hiroshi Mori, James M. Noble, Gerald Reischl, Christopher Rowe, Stephen Salloway, Raquel Sanchez-Valle, Peter R. Schofield, Hiroyuki Shimada, Mikio Shoji, Yi Su, Kazushi Suzuki, Jonathan Vöglein, Igor Yakushev, Carlos Cruchaga, Jason Hassenstab, Celeste Karch, Eric Mcdade, Richard J. Perrin, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger, Dominantly Inherited Alzheimer Network
Positron Emission Tomography And Magnetic Resonance Imaging Methods And Datasets Within The Dominantly Inherited Alzheimer Network (Dian), Nicole S. Mckay, Brian A. Gordon, Russ C. Hornbeck, Aylin Dincer, Shaney Flores, Sarah J. Keefe, Nelly Joseph-Mathurin, Clifford R. Jack, Robert Koeppe, Peter R. Millar, Beau M. Ances, Charles D. Chen, Alisha Daniels, Diana A. Hobbs, Kelley Jackson, Deborah Koudelis, Parinaz Massoumzadeh, Austin Mccullough, Michael L. Nickels, Farzaneh Rahmani, Laura Swisher, Qing Wang, Ricardo F. Allegri, Sarah B. Berman, Adam M. Brickman, William S. Brooks, David M. Cash, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Christian La Fougère, Nick C. Fox, Michael Fulham, Bernardino Ghetti, Neill Graff-Radford, Takeshi Ikeuchi, William Klunk, Jae-Hong Lee, Johannes Levin, Ralph Martins, Colin L. Masters, Jonathan Mcconathy, Hiroshi Mori, James M. Noble, Gerald Reischl, Christopher Rowe, Stephen Salloway, Raquel Sanchez-Valle, Peter R. Schofield, Hiroyuki Shimada, Mikio Shoji, Yi Su, Kazushi Suzuki, Jonathan Vöglein, Igor Yakushev, Carlos Cruchaga, Jason Hassenstab, Celeste Karch, Eric Mcdade, Richard J. Perrin, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger, Dominantly Inherited Alzheimer Network
Research outputs 2022 to 2026
The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations occurring in three genes. Offspring from ADAD families have a 50% chance of inheriting their familial mutation, so non-carrier siblings can be recruited for comparisons in case–control studies. The age of onset in ADAD is highly predictable within families, allowing researchers to estimate an individual’s point in the disease trajectory. These characteristics allow candidate AD biomarker measurements to be reliably mapped during the preclinical phase. Although ADAD represents a small proportion of AD cases, understanding neuroimaging-based changes that occur during …
Sideffect Gameplan: Development Of An Alcohol And Other Drug Serious Game For High School Students Using A Systematic And Iterative User-Centred Game Development Framework, Joanna Nicholas, Brennen Mills, Sara Hansen, Stephen J. Bright, Joseph Scott, Imogen Ridout, Jess Watson, Heather Boyd, Luke Brook, Luke Hopper
Sideffect Gameplan: Development Of An Alcohol And Other Drug Serious Game For High School Students Using A Systematic And Iterative User-Centred Game Development Framework, Joanna Nicholas, Brennen Mills, Sara Hansen, Stephen J. Bright, Joseph Scott, Imogen Ridout, Jess Watson, Heather Boyd, Luke Brook, Luke Hopper
Research outputs 2022 to 2026
Serious games have shown to be effective in improving motivation to learn, knowledge and retention, thus are being increasingly used for alcohol and other drug (AOD) education. This paper outlines the development of an online AOD serious game for in-class use by Australian secondary school teachers for students in Years 9–10. Adapted from Edwards et al. (2018), the seven-step systematic and iterative user-centred development framework included: (1) Forming an expert multidisciplinary design team, (2) Defining the problem and establishing user preferences, (3) Incorporating the evidence base, (4) Serious game design, (5) Incorporating behavioural and psychological theory, (6) Developing a logic …
Interactions Between Mediterranean Diet Supplemented With Dairy Foods And The Gut Microbiota Influence Cardiovascular Health In An Australian Population, Jocelyn M. Choo, Karen J. Murphy, Alexandra T. Wade, Yanan Wang, Ella L. Bracci, Courtney R. Davis, Kathryn A. Dyer, Richard J. Woodman, Jonathan M. Hodgson, Geraint B. Rogers
Interactions Between Mediterranean Diet Supplemented With Dairy Foods And The Gut Microbiota Influence Cardiovascular Health In An Australian Population, Jocelyn M. Choo, Karen J. Murphy, Alexandra T. Wade, Yanan Wang, Ella L. Bracci, Courtney R. Davis, Kathryn A. Dyer, Richard J. Woodman, Jonathan M. Hodgson, Geraint B. Rogers
Research outputs 2022 to 2026
The impact of a Mediterranean diet on the intestinal microbiome has been linked to its health benefits. We aim to evaluate the effects of a Mediterranean diet supplemented with dairy foods on the gut microbiome in Australians at risk of cardiovascular disease. In a randomised controlled cross-over study, 34 adults with a systolic blood pressure ≥120 mmHg and with risk factors for cardiovascular disease were randomly allocated to a Mediterranean diet with 3–4 daily serves of dairy foods (Australian recommended daily intake (RDI) of 1000–1300 mg per day (MedDairy)) or a low-fat (LFD) control diet. Between each 8-week diet, participants …
Prevalence, Knowledge, And Lifestyle-Associated Risk Factors Of Dyslipidemia Among Ghanaian Type-2 Diabetes Mellitus Patients In Rural And Urban Areas: A Multicenter Cross-Sectional Study, Wina I.O. Boadu, Enoch O. Anto, Joseph Frimpong, Felix Ntiful, Emmanuel E. Korsah, Ezekiel Ansah, Valentine C.K.T. Tamakloe, Afia Agyapomaa, Stephen Opoku, Ebenezer Senu, Michael Nyantakyi, Albright Etwi-Mensah, Emmanuel Acheampong, Kwame O. Boadu, Emmanuel Timmy Donkoh, Christian Obirikorang
Prevalence, Knowledge, And Lifestyle-Associated Risk Factors Of Dyslipidemia Among Ghanaian Type-2 Diabetes Mellitus Patients In Rural And Urban Areas: A Multicenter Cross-Sectional Study, Wina I.O. Boadu, Enoch O. Anto, Joseph Frimpong, Felix Ntiful, Emmanuel E. Korsah, Ezekiel Ansah, Valentine C.K.T. Tamakloe, Afia Agyapomaa, Stephen Opoku, Ebenezer Senu, Michael Nyantakyi, Albright Etwi-Mensah, Emmanuel Acheampong, Kwame O. Boadu, Emmanuel Timmy Donkoh, Christian Obirikorang
Research outputs 2022 to 2026
Background and Aims: Dyslipidemia in diabetes mellitus has been linked to unhealthy lifestyle and bad eating habits. However, this association has not been well studied among rural and urban Ghanaian populations. In this study, we determined the prevalence, knowledge, and lifestyle-associated risk factors of dyslipidemia among Ghanaian type-2 diabetes mellitus (T2DM) patients in rural and urban areas. Methods: This comparative multicentre-cross-sectional study recruited 228 T2DM outpatients attending the St. Michael Hospital, Pramso (rural) and Kumasi South Regional Hospital (urban), Ghana for routine check-ups. Self-structured questionnaire was used to collect sociodemographic, knowledge, and lifestyle characteristics. Fasting blood samples were taken to …
Sleep Health Of Young Adults In Western Australia And Associations With Physical And Mental Health: A Population-Level Cross-Sectional Study, Alexandra P. Metse, Peter Eastwood, Melissa Ree, Adrian Lopresti, Joseph J. Scott, Jenny Bowman
Sleep Health Of Young Adults In Western Australia And Associations With Physical And Mental Health: A Population-Level Cross-Sectional Study, Alexandra P. Metse, Peter Eastwood, Melissa Ree, Adrian Lopresti, Joseph J. Scott, Jenny Bowman
Research outputs 2022 to 2026
OBJECTIVES: This article aims to report on the sleep health characteristics of a population-level sample of young Australian adults and examine associations with measures of physical and mental health. METHODS: A cross-sectional study using data from the Raine Study. Data from participants (n = 1234) born into the study (Generation 2) at the 22-year follow-up were used, including data from a self-report questionnaire and polysomnography. RESULTS: The highest prevalence of suboptimal sleep health was seen on measures of sleep duration (30%), onset latency (18%), satisfaction (25%) and regularity (60%). Dissatisfaction with sleep (physical health: =0.08; mental health: =0.34) and impaired …
Application Of Classic Grounded Theory In Nursing Studies: A Qualitative Systematic Review Protocol, Justine Connor, Tracy Flenady, Trudy Dwyer, Debbie Massey
Application Of Classic Grounded Theory In Nursing Studies: A Qualitative Systematic Review Protocol, Justine Connor, Tracy Flenady, Trudy Dwyer, Debbie Massey
Research outputs 2022 to 2026
Introduction Classic grounded theory (CGT) is a valuable method for nursing research, but the application of CGT methodology in nursing studies has not been specifically investigated. With the increasing use of CGT in nursing research, attention is now focusing on the quality of studies using this methodology. In this systematic review, we aim to develop an understanding of the application of CGT methodology, specifically appraising the quality of the methodology's application in the field of nursing research. Methods and analysis The reporting of this review will be guided by the Preferred Reporting Items for Systematic and Meta-Analysis guidelines statement and …
Protocol: Can Coronary Artery Calcium Score Identified On Thoracic Planning Ct Scans Be Used And Actioned To Identify Cancer Survivors At High Risk Of Cardiac Events: A Feasibility Study In Cancer Survivors Undergoing Radiotherapy In Australia, Jack Dalla Via, Nina Stewart, Mary A. Kennedy, Daniel A. Cehic, Peter Purnell, Joanne Toohey, Jamie Morton, Sabashini K. Ramchand, Joshua R. Lewis, Yvonne Zissiadis
Protocol: Can Coronary Artery Calcium Score Identified On Thoracic Planning Ct Scans Be Used And Actioned To Identify Cancer Survivors At High Risk Of Cardiac Events: A Feasibility Study In Cancer Survivors Undergoing Radiotherapy In Australia, Jack Dalla Via, Nina Stewart, Mary A. Kennedy, Daniel A. Cehic, Peter Purnell, Joanne Toohey, Jamie Morton, Sabashini K. Ramchand, Joshua R. Lewis, Yvonne Zissiadis
Research outputs 2022 to 2026
INTRODUCTION: A coronary artery calcium (CAC) CT scan can identify calcified plaque and predict risk of future cardiac events. Cancer survivors undergoing thoracic radiotherapy routinely undergo a planning CT scan, which presents a unique opportunity to use already obtained medical imaging to identify those at the highest risk of cardiac events. While radiation therapy is an important modality for many cancer treatments, radiation dose to the heart in thoracic radiotherapy leads to cardiotoxicity and may accelerate pre-existing atherosclerosis. The primary aims of this study are to investigate the feasibility of using CAC scores calculated on thoracic radiotherapy planning CT scans …
Separate And Joint Associations Of Remnant Cholesterol Accumulation And Variability With Carotid Atherosclerosis: A Prospective Cohort Atudy, Jinqi Wang, Rui Jin, Xiaohan Jin, Zhiyuan Wu, Haiping Zhang, Ze Han, Zongkai Xu, Yueruijing Liu, Xiaoyu Zhao, Xiuhua Guo, Lixin Tao
Separate And Joint Associations Of Remnant Cholesterol Accumulation And Variability With Carotid Atherosclerosis: A Prospective Cohort Atudy, Jinqi Wang, Rui Jin, Xiaohan Jin, Zhiyuan Wu, Haiping Zhang, Ze Han, Zongkai Xu, Yueruijing Liu, Xiaoyu Zhao, Xiuhua Guo, Lixin Tao
Research outputs 2022 to 2026
Background: We aimed to examine separate and joint associations of remnant cholesterol (RC) accumulation and variability with the risk of carotid atherosclerosis (CAS) in the general population. Methods and Results: A total of 6213 participants who underwent 3 sequential health examinations during 2010 to 2015 were enrolled and were followed up until December 31, 2021. Cumulative RC (cumRC) and RC variability among the 3 visits were the exposure of interest in our study. Adjusted Cox models were performed to calculate the hazard ratio (HR) and 95% CI. C-statistics, integrated discrimination improvement, and the net reclassification index were used to estimate …
Temporal And Bidirectional Association Between Blood Pressure Variability And Arterial Stiffness: Cross-Lagged Cohort Study, Zhiyuan Wu, Haiping Zhang, Yutao Wang, Zhiwei Li, Xia Li, Lixin Tao, Xiuhua Guo
Temporal And Bidirectional Association Between Blood Pressure Variability And Arterial Stiffness: Cross-Lagged Cohort Study, Zhiyuan Wu, Haiping Zhang, Yutao Wang, Zhiwei Li, Xia Li, Lixin Tao, Xiuhua Guo
Research outputs 2022 to 2026
BACKGROUND: The causal relationship between blood pressure variability (BPV) and arterial stiffness remains debated. OBJECTIVE: This study aimed to explore the temporal and bidirectional associations between long-term BPV and arterial stiffness using a cohort design with multiple surveys. METHODS: Participants from the Beijing Health Management Cohort who underwent health examinations from visit 1 (2010-2011) to visit 5 (2018-2019) were enrolled in this study. Long-term BPV was defined as intraindividual variation using the coefficient of variation (CV) and SD. Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV). The bidirectional relationship between BPV and arterial stiffness was explored using cross-lagged …
Cardiometabolic Syndrome Among General Adult Population In Ghana: The Role Of Lipid Accumulation Product, Waist Circumference-Triglyceride Index, And Triglyceride-Glucose Index As Surrogate Indicators, Enoch O. Anto, Joseph Frimpong, Wina I. O. Boadu, Emmanuel E. Korsah, Valentine C. K. T. Tamakloe, Ezekiel Ansah, Stephen Opoku, Emmanuel Acheampong, Evans A. Asamoah, Patience Nyarkoa, Eric Adua, Ebenezer Afrifa-Yamoah, Max E. Annani-Akollor, Christian Obirikorang
Cardiometabolic Syndrome Among General Adult Population In Ghana: The Role Of Lipid Accumulation Product, Waist Circumference-Triglyceride Index, And Triglyceride-Glucose Index As Surrogate Indicators, Enoch O. Anto, Joseph Frimpong, Wina I. O. Boadu, Emmanuel E. Korsah, Valentine C. K. T. Tamakloe, Ezekiel Ansah, Stephen Opoku, Emmanuel Acheampong, Evans A. Asamoah, Patience Nyarkoa, Eric Adua, Ebenezer Afrifa-Yamoah, Max E. Annani-Akollor, Christian Obirikorang
Research outputs 2022 to 2026
Background: Visceral obesity and insulin resistance contribute to developing cardiometabolic syndrome (MetS). We investigated the predictive abilities of lipid accumulation product (LAP), waist circumference-triglyceride index (WTI), and triglyceride-glucose (TyG) index for MetS screening among the general Ghanaian adults. Methods: The final prospective analysis included 4740 healthy adults aged 30–90 years from three communities comprising Ejisu, Konongo, and Ashanti Akim Agogo in Ghana. Self-structured questionnaire pretested was used to collect sociodemographic, anthropometric, and clinical data. Blood samples were taken after fasting to measure glucose and lipid levels. LAP, WTI, and TyG were calculated from standard equations. MetS was defined by the …
Genomic Analysis Of Clostridioides Difficile Recovered From Horses In Western Australia, Natasza M. R. Hain-Saunders, Daniel R. Knight, Mieghan Bruce, David Byrne, Thomas V. Riley
Genomic Analysis Of Clostridioides Difficile Recovered From Horses In Western Australia, Natasza M. R. Hain-Saunders, Daniel R. Knight, Mieghan Bruce, David Byrne, Thomas V. Riley
Research outputs 2022 to 2026
Clostridioides difficile poses an ongoing threat as a cause of gastrointestinal disease in humans and animals. Traditionally considered a human healthcare-related disease, increases in community-associated C. difficile infection (CDI) and growing evidence of inter-species transmission suggest a wider perspective is required for CDI control. In horses, C. difficile is a major cause of diarrhoea and life-threatening colitis. This study aimed to better understand the epidemiology of CDI in Australian horses and provide insights into the relationships between horse, human and environmental strains. A total of 752 faecal samples from 387 Western Australian horses were collected. C. difficile was isolated from …
Glycomedicine: The Current State Of The Art, Wei Wang
Glycomedicine: The Current State Of The Art, Wei Wang
Research outputs 2022 to 2026
No abstract provided.
Effects Of Unilateral Eccentric Versus Concentric Training Of Nonimmobilized Arm During Immobilization, Trevor C. Chen, Shang-Hen Wu, Hsin-Lian Chen, Wei-Chin Tseng, Kuo-Wei Tseng, Hsing-Yu Kang, Kazunori Nosaka
Effects Of Unilateral Eccentric Versus Concentric Training Of Nonimmobilized Arm During Immobilization, Trevor C. Chen, Shang-Hen Wu, Hsin-Lian Chen, Wei-Chin Tseng, Kuo-Wei Tseng, Hsing-Yu Kang, Kazunori Nosaka
Research outputs 2022 to 2026
Introduction The present study tested the hypothesis that eccentric training (ET) of nonimmobilized arm would attenuate negative effects of immobilization and provide greater protective effects against muscle damage induced by eccentric exercise after immobilization, when compared with concentric training (CT). Methods Sedentary young men were placed to ET, CT, or control group (n = 12 per group), and their nondominant arms were immobilized for 3 wk. During the immobilization period, the ET and CT groups performed five sets of six dumbbell curl eccentric-only and concentric-only contractions, respectively, at 20%-80% of maximal voluntary isometric contraction (MVCiso) strength over six sessions. MVCiso …
Drug Regulatory-Compliant Validation Of A Qpcr Assay For Bioanalysis Studies Of A Cell Therapy Product With A Special Focus On Matrix Interferences In A Wide Range Of Organ Tissues, Hannes M. Schröder, Elke Niebergall-Roth, Alexandra Norrick, Jasmina Esterlechner, Christoph Ganss, Markus H. Frank, Mark A. Kluth
Drug Regulatory-Compliant Validation Of A Qpcr Assay For Bioanalysis Studies Of A Cell Therapy Product With A Special Focus On Matrix Interferences In A Wide Range Of Organ Tissues, Hannes M. Schröder, Elke Niebergall-Roth, Alexandra Norrick, Jasmina Esterlechner, Christoph Ganss, Markus H. Frank, Mark A. Kluth
Research outputs 2022 to 2026
Quantitative polymerase chain reaction (qPCR) has emerged as an important bioanalytical method for assessing the pharmacokinetics of human-cell-based medicinal products after xenotransplantation into immunodeficient mice. A particular challenge in bioanalytical qPCR studies is that the different tissues of the host organism can affect amplification efficiency and amplicon detection to varying degrees, and ignoring these matrix effects can easily cause a significant underestimation of the true number of target cells in a sample. Here, we describe the development and drug regulatory-compliant validation of a TaqMan qPCR assay for the quantification of mesenchymal stromal cells in the range of 125 to 20,000 …
Patients’ Acceptance Of Outcome And Experience Measurements During Hospitalisation For Copd Exacerbations: A Cicero Clinical Research Collaboration–European Lung Foundation Online Patient Survey, Iwein Gyselinck, Sanjay Ramakrishnan, Kristina Vermeersch, Andreas Halner, Hendrik Pott, Fabienne Dobbels, Courtney Coleman, Philip Collis, Henrik Watz, Timm Greulich, Frits M. E. Franssen, Pierre-Régis Burgel, Mona Bafadhel, Wim Janssens, Cicero Consortium
Patients’ Acceptance Of Outcome And Experience Measurements During Hospitalisation For Copd Exacerbations: A Cicero Clinical Research Collaboration–European Lung Foundation Online Patient Survey, Iwein Gyselinck, Sanjay Ramakrishnan, Kristina Vermeersch, Andreas Halner, Hendrik Pott, Fabienne Dobbels, Courtney Coleman, Philip Collis, Henrik Watz, Timm Greulich, Frits M. E. Franssen, Pierre-Régis Burgel, Mona Bafadhel, Wim Janssens, Cicero Consortium
Research outputs 2022 to 2026
Background: The lack of standardised outcome assessments during hospitalisation and follow-up for acute COPD exacerbations has hampered scientific progress and clinical proficiency. The objective of the present study was to evaluate patients’ acceptance of selected outcome and experience measurements during hospitalisations for COPD exacerbations and follow-up. Methods: An online survey was held amongst COPD patients in France, Belgium, The Netherlands, Germany and the UK. The European Lung Foundation COPD Patient Advisory Group was involved in the conceptualisation, development and dissemination of the survey. The survey was complementary to a previously obtained expert consensus. We assessed patients’ views and acceptance of …
The Origins Project Biobank: A Collaborative Bio Resource For Investigating The Developmental Origins Of Health And Disease, Nina D’Vaz, Courtney Kidd, Sarah Miller, Minda Amin, Jacqueline A. Davis, Zenobia Talati, Desiree T. Silva, Susan L. Prescott
The Origins Project Biobank: A Collaborative Bio Resource For Investigating The Developmental Origins Of Health And Disease, Nina D’Vaz, Courtney Kidd, Sarah Miller, Minda Amin, Jacqueline A. Davis, Zenobia Talati, Desiree T. Silva, Susan L. Prescott
Research outputs 2022 to 2026
Early onset Non-Communicable Diseases (NCDs), including obesity, allergies, and mental ill-health in childhood, present a serious and increasing threat to lifelong health and longevity. The ORGINS Project (ORIGINS) addresses the urgent need for multidisciplinary efforts to understand the detrimental multisystem impacts of modern environments using well-curated large-scale longitudinal biological sample collections. ORGINS is a prospective community birth cohort aiming to enrol 10,000 pregnant people and follow each family until the children reach 5 years of age. A key objective is to generate a comprehensive biorepository on a sub-group of 4000 families invited to contribute blood, saliva, buccal cells, urine, stool, …
Ers International Congress 2022: Highlights From The Thoracic Oncology Assembly, Maria J. Catarata, Wouter H. Van Geffen, Radhika Banka, Beatriz Ferraz, Calvin Sidhu, Alan Carew, Lucia Viola, Rolof Gijtenbeek, Georgia Hardavella
Ers International Congress 2022: Highlights From The Thoracic Oncology Assembly, Maria J. Catarata, Wouter H. Van Geffen, Radhika Banka, Beatriz Ferraz, Calvin Sidhu, Alan Carew, Lucia Viola, Rolof Gijtenbeek, Georgia Hardavella
Research outputs 2022 to 2026
Thoracic malignancies are associated with a substantial public health burden. Lung cancer is the leading cause of cancer-related mortality worldwide, with significant impact on patients’ quality of life. Following 2 years of virtual European Respiratory Society (ERS) Congresses due to the COVID-19 pandemic, the 2022 hybrid ERS Congress in Barcelona, Spain allowed peers from all over the world to meet again and present their work. Thoracic oncology experts presented best practices and latest developments in lung cancer screening, lung cancer diagnosis and management. Early lung cancer diagnosis, subsequent pros and cons of aggressive management, identification and management of systemic treatments’ …
Plasma Glial Fibrillary Acidic Protein In Autosomal Dominant Alzheimer's Disease: Associations With Aβ-Pet, Neurodegeneration, And Cognition, Pratishtha Chatterjee, Lisa Vermunt, Brian A. Gordon, Steve Pedrini, Lynn Boonkamp, Nicola J. Armstrong, Chengjie Xiong, Abhay K. Singh, Yan Li, Hamid R. Sohrabi, Kevin Taddei, Mark Molloy, Tammie L. S. Benzinger, John C. Morris, Celeste Karch, Sarah Berman, Jasmeer Chhatwal, Carlos Cruchaga, Neill R. Graff-Radford, Gregory S. Day, Martin Farlow, Nick Fox, Alison Goate, Jason Hassenstab, Jae-Hong Lee, Johannes Levin, Eric Mcdade, Hiroshi Mori, Richard Perrin, Raquel Sanchez-Valle, Peter R. Schofield, Allan Levey, Mathias Jucker, Colin L. Masters, Anne M. Fagan, Randall J. Bateman, Ralph N. Martins, Charlotte Teunissen, Dominantly Inherited Alzheimer Network
Plasma Glial Fibrillary Acidic Protein In Autosomal Dominant Alzheimer's Disease: Associations With Aβ-Pet, Neurodegeneration, And Cognition, Pratishtha Chatterjee, Lisa Vermunt, Brian A. Gordon, Steve Pedrini, Lynn Boonkamp, Nicola J. Armstrong, Chengjie Xiong, Abhay K. Singh, Yan Li, Hamid R. Sohrabi, Kevin Taddei, Mark Molloy, Tammie L. S. Benzinger, John C. Morris, Celeste Karch, Sarah Berman, Jasmeer Chhatwal, Carlos Cruchaga, Neill R. Graff-Radford, Gregory S. Day, Martin Farlow, Nick Fox, Alison Goate, Jason Hassenstab, Jae-Hong Lee, Johannes Levin, Eric Mcdade, Hiroshi Mori, Richard Perrin, Raquel Sanchez-Valle, Peter R. Schofield, Allan Levey, Mathias Jucker, Colin L. Masters, Anne M. Fagan, Randall J. Bateman, Ralph N. Martins, Charlotte Teunissen, Dominantly Inherited Alzheimer Network
Research outputs 2022 to 2026
Background: Glial fibrillary acidic protein (GFAP) is a promising candidate blood-based biomarker for Alzheimer's disease (AD) diagnosis and prognostication. The timing of its disease-associated changes, its clinical correlates, and biofluid-type dependency will influence its clinical utility. Methods: We evaluated plasma, serum, and cerebrospinal fluid (CSF) GFAP in families with autosomal dominant AD (ADAD), leveraging the predictable age at symptom onset to determine changes by stage of disease. Results: Plasma GFAP elevations appear a decade before expected symptom onset, after amyloid beta (A ) accumulation and prior to neurodegeneration and cognitive decline. Plasma GFAP distinguished A -positive from A -negative ADAD …
Abcb5+ Limbal Epithelial Stem Cells Inhibit Developmental But Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal Inflammation, Berbang Meshko, Thomas L. A. Volatier, Karina Hadrian, Shuya Deng, Yanhong Hou, Mark A. Kluth, Christoph Ganss, Markus H. Frank, Natasha Y. Frank, Bruce Ksander, Claus Cursiefen, Maria Notara
Abcb5+ Limbal Epithelial Stem Cells Inhibit Developmental But Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal Inflammation, Berbang Meshko, Thomas L. A. Volatier, Karina Hadrian, Shuya Deng, Yanhong Hou, Mark A. Kluth, Christoph Ganss, Markus H. Frank, Natasha Y. Frank, Bruce Ksander, Claus Cursiefen, Maria Notara
Research outputs 2022 to 2026
The limbus, the vascularized junction between the cornea and conjunctiva, is thought to function as a barrier against corneal neovascularization. However, the exact mechanisms regulating this remain unknown. In this study, the limbal epithelial stem cell (LESC) marker ABCB5 was used to investigate the role of LESCs in corneal neovascularization. In an ABCB5KO model, a mild but significant increase of limbal lymphatic and blood vascular network complexity was observed in developing mice (4 weeks) but not in adult mice. Conversely, when using a cornea suture model, the WT animals exhibited a mild but significant increase in the number of lymphatic …
Anonymous Editorials In Biomedical Research Journals: Few In Number But Potentially Problematic, James L. Nuzzo
Anonymous Editorials In Biomedical Research Journals: Few In Number But Potentially Problematic, James L. Nuzzo
Research outputs 2022 to 2026
Editorials are typically brief comments by a journal's chief editor or associate editors on journal news, study findings, or trends in science or practice. Anonymous editorials, which account for 1%–3% of editorials indexed in PubMed, are those in which the author's name is absent or replaced by the journal's name. Chief editors cannot be assumed to be the authors of anonymous editorials, which causes multiple issues. Anonymous editorials prevent readers from assessing the author's potential conflicts of interest and their credibility for discussing the editorial's topic. Anonymous editorials also make credit and accountability for ideas in editorials difficult to establish …
Abcb5+ Mesenchymal Stromal Cells Facilitate Complete And Durable Wound Closure In Recessive Dystrophic Epidermolysis Bullosa, Kathrin Dieter, Elke Niebergall-Roth, Cristina Daniele, Silvia Fluhr, Natasha Y. Frank, Christoph Ganss, Dimitra Kiritsi, John A. Mcgrath, Jakub Tolar, Markus H. Frank, Mark A. Kluth
Abcb5+ Mesenchymal Stromal Cells Facilitate Complete And Durable Wound Closure In Recessive Dystrophic Epidermolysis Bullosa, Kathrin Dieter, Elke Niebergall-Roth, Cristina Daniele, Silvia Fluhr, Natasha Y. Frank, Christoph Ganss, Dimitra Kiritsi, John A. Mcgrath, Jakub Tolar, Markus H. Frank, Mark A. Kluth
Research outputs 2022 to 2026
Background and aims: Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary, rare, devastating and life-threatening skin fragility disorder with a high unmet medical need. In a recent international, single-arm clinical trial, treatment of 16 patients (aged 6–36 years) with three intravenous infusions of 2 × 106 immunomodulatory ABCB5+ dermal mesenchymal stromal cells (MSCs)/kg on days 0, 17 and 35 reduced disease activity, itch and pain. A post-hoc analysis was undertaken to assess the potential effects of treatment with ABCB5+ MSCs on the overall skin wound healing in patients suffering from RDEB. Methods: Documentary photographs of the affected body regions taken …
Association Between Long-Term Exposure To Fine Particulate Matter Constituents And Progression Of Cerebral Blood Flow Velocity In Beijing: Modifying Effect Of Greenness, Zongkai Xu, Ze Han, Jinqi Wang, Rui Jin, Zhiwei Li, Zhiyuan Wu, Zemeng Zhao, Shiyun Lv, Xiaoyu Zhao, Yueruijing Liu, Xiuhua Guo, Lixin Tao
Association Between Long-Term Exposure To Fine Particulate Matter Constituents And Progression Of Cerebral Blood Flow Velocity In Beijing: Modifying Effect Of Greenness, Zongkai Xu, Ze Han, Jinqi Wang, Rui Jin, Zhiwei Li, Zhiyuan Wu, Zemeng Zhao, Shiyun Lv, Xiaoyu Zhao, Yueruijing Liu, Xiuhua Guo, Lixin Tao
Research outputs 2022 to 2026
Few studies have explored the effects of fine particulate matter (PM2.5) and its constituents on the progression of cerebral blood flow velocity (BFV) and the potential modifying role of greenness. In this study, we investigated the association of PM2.5 and its constituents, including sulfate (SO42−), nitrate (NO3−), ammonium (NH4+), organic matter (OM), and black carbon (BC), with the progression of BFV in the middle cerebral artery. Participants from the Beijing Health Management Cohort who underwent at least two transcranial Doppler sonography examinations during 2015–2020 were recruited. BFV change and BFV change rate were used to define the progression of cerebral …
Causal Associations Of Air Pollution With Cardiovascular Disease And Respiratory Diseases Among Elder Diabetic Patients, Zhiwei Li, Shiyun Lv, Feng Lu, Moning Guo, Zhiyuan Wu, Yue Liu, Weiming Li, Mengmeng Liu, Siqi Yu, Yanshuang Jiang, Bo Gao, Xiaonan Wang, Xia Li, Wei Wang, Xiangtong Liu, Xiuhua Guo
Causal Associations Of Air Pollution With Cardiovascular Disease And Respiratory Diseases Among Elder Diabetic Patients, Zhiwei Li, Shiyun Lv, Feng Lu, Moning Guo, Zhiyuan Wu, Yue Liu, Weiming Li, Mengmeng Liu, Siqi Yu, Yanshuang Jiang, Bo Gao, Xiaonan Wang, Xia Li, Wei Wang, Xiangtong Liu, Xiuhua Guo
Research outputs 2022 to 2026
Extensive researches have linked air pollutants with cardiovascular disease (CVD) and respiratory diseases (RD), however, there is limited evidence on causal effects of air pollutants on morbidity of CVD or RD with comorbidities, particularly diabetes mellitus in elder patients. We included hospital admissions for CVD or RD among elder ( ≥ 65 years) diabetic patients between 2014 and 2019 in Beijing. A time-stratified case-crossover design based on negative-control exposure was used to assess causal associations of short-term exposure to air pollutants with CVD and RD among diabetic patients with the maximum lag of 7 days. A random forest regression model …
Experiences And Perspectives Of Children And Young People Living With Childhood-Onset Systemic Lupus Erythematosus—An Integrative Review, Julie Blamires, Mandie Foster, Sara Napier, Annette Dickinson
Experiences And Perspectives Of Children And Young People Living With Childhood-Onset Systemic Lupus Erythematosus—An Integrative Review, Julie Blamires, Mandie Foster, Sara Napier, Annette Dickinson
Research outputs 2022 to 2026
Childhood-onset systemic lupus erythematosus (cSLE) impacts the daily life of children and young people. This study aimed to describe the experiences and perspectives of children and young people living with cSLE. An integrative review guided by Whittemore and Knafl was conducted. Extant empirical research published in peer-reviewed journals from 2000 to 2021 on children’s self-reported experiences living with cSLE was identified from Scopus, CINAHL, Medline via PubMed, and PsycINFO via Ovid databases. Nineteen studies involving over 1400 participants were included. Four themes and fourteen sub-themes were identified: (1) challenging symptoms (disruptions to life and altered self, severity, fatigue, depression, and …